title: “Two_brain_samples” author: “Shenfeng Qiu” date: “12/03/2022” output: html_document number_sections: yes df_print: paged editor_options: chunk_output_type: console—
Analyzing scRNA-seq Data, Harrison Stratton two libraries. dissected DRG tissue; m10 =CTL, m11 = TRT
seurat_integrated = readRDS(“./v1_output/seurat_integrated_twobrainsamples_12052022.RDS”)
Initialize relevant libraries
Import two samples
# You might need to change the location "slim_counts/", to direct to your data folder
for (file in c("m10",
"m11")){
seurat_data <- Read10X(data.dir = paste0("D:/Bioinformatics Projects/sc_exp7/", file))
seurat_obj <- CreateSeuratObject(counts = seurat_data,
min.features = 100,
project = file)
assign(file, seurat_obj)
}
m10 <- AddMetaData(object = m10, metadata = "m10", col.name = "sample.id")
m11 <- AddMetaData(object = m11, metadata = "m11", col.name = "sample.id")
m10 <- AddMetaData(object = m10, metadata = "CTL", col.name = "group.id")
m11 <- AddMetaData(object = m11, metadata = "TRT", col.name = "group.id")
gallitano <- merge(m10, y = m11, add.cell.ids = c("m10","m11"), project = "two_samples")
gallitano[["percent.mt"]] <- PercentageFeatureSet(gallitano, pattern = "^mt-")
# 32885 genes,32391 cells
rm(m10)
rm(m11)
rm(seurat_obj, seurat_data)
head(gallitano)## orig.ident nCount_RNA nFeature_RNA sample.id group.id
## m10_AAACCCAAGACCTCAT-1 m10 1201 890 m10 CTL
## m10_AAACCCAAGAGATTCA-1 m10 1790 1169 m10 CTL
## m10_AAACCCAAGAGGGTAA-1 m10 1503 1019 m10 CTL
## m10_AAACCCAAGATGAATC-1 m10 2438 1538 m10 CTL
## m10_AAACCCAAGCGACCCT-1 m10 2291 1438 m10 CTL
## m10_AAACCCAAGCTCGTGC-1 m10 1600 1086 m10 CTL
## m10_AAACCCAAGGACATCG-1 m10 1316 967 m10 CTL
## m10_AAACCCAAGGGTGAGG-1 m10 1179 897 m10 CTL
## m10_AAACCCAAGTAGGATT-1 m10 1213 908 m10 CTL
## m10_AAACCCAAGTGCGCTC-1 m10 2145 1375 m10 CTL
## percent.mt
## m10_AAACCCAAGACCTCAT-1 4.163197
## m10_AAACCCAAGAGATTCA-1 3.016760
## m10_AAACCCAAGAGGGTAA-1 4.324684
## m10_AAACCCAAGATGAATC-1 6.152584
## m10_AAACCCAAGCGACCCT-1 4.888695
## m10_AAACCCAAGCTCGTGC-1 6.437500
## m10_AAACCCAAGGACATCG-1 6.382979
## m10_AAACCCAAGGGTGAGG-1 3.138253
## m10_AAACCCAAGTAGGATT-1 4.699093
## m10_AAACCCAAGTGCGCTC-1 4.988345tail(gallitano)## orig.ident nCount_RNA nFeature_RNA sample.id group.id
## m11_TTTGTTGGTGTGACCC-1 m11 2656 1588 m11 TRT
## m11_TTTGTTGGTTCCGCTT-1 m11 1885 1147 m11 TRT
## m11_TTTGTTGTCAGATGCT-1 m11 1958 1282 m11 TRT
## m11_TTTGTTGTCATAGACC-1 m11 1666 1151 m11 TRT
## m11_TTTGTTGTCCCTCGTA-1 m11 10041 3903 m11 TRT
## m11_TTTGTTGTCCTGGGAC-1 m11 19589 5607 m11 TRT
## m11_TTTGTTGTCGCGCCAA-1 m11 1297 922 m11 TRT
## m11_TTTGTTGTCGCTCCTA-1 m11 6855 3146 m11 TRT
## m11_TTTGTTGTCTAGTTCT-1 m11 929 673 m11 TRT
## m11_TTTGTTGTCTGGAGAG-1 m11 1065 727 m11 TRT
## percent.mt
## m11_TTTGTTGGTGTGACCC-1 7.040663
## m11_TTTGTTGGTTCCGCTT-1 8.594164
## m11_TTTGTTGTCAGATGCT-1 6.537283
## m11_TTTGTTGTCATAGACC-1 4.861945
## m11_TTTGTTGTCCCTCGTA-1 5.587093
## m11_TTTGTTGTCCTGGGAC-1 4.298331
## m11_TTTGTTGTCGCGCCAA-1 7.016191
## m11_TTTGTTGTCGCTCCTA-1 4.507659
## m11_TTTGTTGTCTAGTTCT-1 10.226050
## m11_TTTGTTGTCTGGAGAG-1 10.328638Quality Control
# For all the png function in the following, try to replace the url address with your output folder
# you can use the "Ctrl + F" the search bar, to replace all the relevant folder address
png(filename = "./v1_output/QC_beforefiltering.png",
width = 600, height = 1000)
VlnPlot(gallitano,
features = c("nFeature_RNA", "nCount_RNA", "percent.mt"),
group.by = "sample.id",
ncol = 3) + ggtitle("Quality assessment before filtering")
dev.off()## png
## 2png(file = "./v1_output/QC_FeatureScatter.png", width = 1000, height = 500) #skip this line to output to console, or after png file is generated and dev.off, then run the following lines to output to console
plot1 <- FeatureScatter(gallitano, feature1 = "nCount_RNA", feature2 = "percent.mt")
line.data <- data.frame(yintercept = c(1500, 7500), Lines = c("lower", "upper"))
line2.data <- data.frame(xintercept = c(500), Lines = c("lower"))
plot2 <- FeatureScatter(gallitano, feature1 = "nCount_RNA", feature2 = "nFeature_RNA") + geom_hline(aes(yintercept = yintercept, linetype = Lines), line.data) + geom_vline(aes(xintercept = xintercept, linetype = Lines), line2.data)
plot1 + plot2 + plot_layout(guides = 'collect') + plot_annotation(title = "Quality assessment before filtering")
dev.off()## png
## 2Joint filtering effects:
# joint filtering effect
# Visualize the correlation between genes detected and number of UMIs and determine whether strong presence of cells with low numbers of genes/UMIs
metadata <- gallitano@meta.data
png(file = "./v1_output/QC_jointfilteringeffect.png", width = 600, height = 500) #skip this line to output to console, or after png file is generated and dev.off, then run the following lines to output to console
metadata %>%
ggplot(aes(x=nCount_RNA, y=nFeature_RNA, color=percent.mt)) +
geom_point() +
scale_colour_gradient(low = "gray90", high = "black") +
stat_smooth(method=lm) +
scale_x_log10() +
scale_y_log10() +
theme_classic() +
geom_vline(xintercept = 500) +
geom_hline(yintercept = c(1500, 7500))## `geom_smooth()` using formula = 'y ~ x'## Warning: The following aesthetics were dropped during statistical transformation: colour
## ℹ This can happen when ggplot fails to infer the correct grouping structure in
## the data.
## ℹ Did you forget to specify a `group` aesthetic or to convert a numerical
## variable into a factor?dev.off()## png
## 2Selecting Data Subset
I follow the original script to filter based on these criteria: nFeature_RNA < 7500& nFeature_RNA>1500 & nCount_RNA > 500 and then, I added the filtering criteria of “percent.mt < 20” After subseting, I also remove the genes with zero count in more than 100 cells
gallitano <- subset(gallitano, nFeature_RNA < 7500 &
nFeature_RNA>1250 & nCount_RNA > 2000 &
percent.mt < 15)
dim(gallitano)## [1] 32285 14159# Output a logical vector for every gene on whether the more than zero counts per cell
# Extract counts
counts <- GetAssayData(object = gallitano, slot = "counts")
# Output a logical vector for every gene on whether the more than zero counts per cell
nonzero <- counts > 0
# Sums all TRUE values and returns TRUE if more than 100 TRUE values per gene
keep_genes <- Matrix::rowSums(nonzero) >= 20
# Only keeping those genes expressed in more than 100 cells
filtered_counts <- counts[keep_genes, ]
# Reassign to filtered Seurat object
gallitano <- CreateSeuratObject(filtered_counts, meta.data = gallitano@meta.data)
dim(gallitano)## [1] 18387 14159# 18948 genes * 24853 cells
rm(filtered_counts,nonzero, counts, keep_genes, file)Reassess quality metrics
dim(gallitano)## [1] 18387 14159# 32285 14159
png(file = "./v1_output/QC_afterfiltering.png", width = 800, height = 800) #skip this line to output to console, or after png file is generated and dev.off, then run the following lines to output to console
VlnPlot(gallitano,
features = c("nFeature_RNA", "nCount_RNA", "percent.mt"),
ncol = 3) + ggtitle("Quality assessment after filtering")
dev.off()## png
## 2png(file = "./v1_output/QC_FeatureScatter_after.png", width = 1000, height = 500)
plot1 <- FeatureScatter(gallitano, feature1 = "nCount_RNA", feature2 = "percent.mt")
line.data <- data.frame(yintercept = c(1500, 7500), Lines = c("lower", "upper"))
line2.data <- data.frame(xintercept = c(500), Lines = c("lower"))
plot2 <- FeatureScatter(gallitano, feature1 = "nCount_RNA", feature2 = "nFeature_RNA") + geom_hline(aes(yintercept = yintercept, linetype = Lines), line.data) + geom_vline(aes(xintercept = xintercept, linetype = Lines), line2.data)
plot1 + plot2 + plot_layout(guides = 'collect') + plot_annotation(title = "Quality assessment after filtering")
dev.off()## png
## 2metadata <- gallitano@meta.data
png(file = "./v1_output/QC_jointfilteringeffect_after.png", width = 600, height = 500) #skip this line to output to console, or after png file is generated and dev.off, then run the following lines to output to console
metadata %>%
ggplot(aes(x=nCount_RNA, y=nFeature_RNA, color=percent.mt)) +
geom_point() +
scale_colour_gradient(low = "gray90", high = "black") +
stat_smooth(method=lm) +
scale_x_log10() +
scale_y_log10() +
theme_classic() +
geom_vline(xintercept = 500) +
geom_hline(yintercept = c(1500, 7500))## `geom_smooth()` using formula = 'y ~ x'## Warning: The following aesthetics were dropped during statistical transformation: colour
## ℹ This can happen when ggplot fails to infer the correct grouping structure in
## the data.
## ℹ Did you forget to specify a `group` aesthetic or to convert a numerical
## variable into a factor?dev.off()## png
## 2Apply sctransform normalization
This steps can replace NormalizeData(),
ScaleData(), and FindVariableFeatures(). The
results of sctransform are stored in the “SCT” assay. It is assumed to
reveals sharper biological distinctions compared to the standard Seurat
workflow.
Since it is a normalization step, we have to do
separately for two different samples (that’s why split seurat objects
here), then only integrate the sample expression data in the next step,
integration analysis, to remove batch effect.
options(future.globals.maxSize = 9000 * 1024^2) #100 gb
# Split seurat object by condition to perform cell cycle scoring and SCT on all samples
split_seurat <- SplitObject(gallitano, split.by = "sample.id")
split_seurat <- split_seurat[c("m10", "m11")]
for (i in 1:length(split_seurat)) {
split_seurat[[i]] <- NormalizeData(split_seurat[[i]], verbose = TRUE)
split_seurat[[i]] <- SCTransform(split_seurat[[i]], vars.to.regress = c("percent.mt"))
}## Calculating cell attributes from input UMI matrix: log_umi## Variance stabilizing transformation of count matrix of size 18240 by 7660## Model formula is y ~ log_umi## Get Negative Binomial regression parameters per gene## Using 2000 genes, 5000 cells##
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|======================================================================| 100%## Calculating gene attributes## Wall clock passed: Time difference of 1.739468 mins## Determine variable features## Place corrected count matrix in counts slot## Regressing out percent.mt## Centering data matrix## Set default assay to SCT## Calculating cell attributes from input UMI matrix: log_umi## Variance stabilizing transformation of count matrix of size 18373 by 6499## Model formula is y ~ log_umi## Get Negative Binomial regression parameters per gene## Using 2000 genes, 5000 cells##
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|======================================================================| 100%## Calculating gene attributes## Wall clock passed: Time difference of 1.71347 mins## Determine variable features## Place corrected count matrix in counts slot## Regressing out percent.mt## Centering data matrix## Set default assay to SCTrm(gallitano)Integration
# Select the most variable features to use for integration
integ_features <- SelectIntegrationFeatures(object.list = split_seurat,
nfeatures = 3000)
# Prepare the SCT list object for integration
split_seurat <- PrepSCTIntegration(object.list = split_seurat,
anchor.features = integ_features)
# Find best buddies - can take a while to run
integ_anchors <- FindIntegrationAnchors(object.list = split_seurat,
normalization.method = "SCT",
anchor.features = integ_features)## Finding all pairwise anchors## Running CCA## Merging objects## Finding neighborhoods## Finding anchors## Found 12374 anchors## Filtering anchors## Retained 10543 anchors# Integrate across conditions
seurat_integrated <- IntegrateData(anchorset = integ_anchors,
normalization.method = "SCT")## Merging dataset 2 into 1## Extracting anchors for merged samples## Finding integration vectors## Finding integration vector weights## Integrating datarm(integ_anchors)
rm(integ_features)
rm(split_seurat)Clustering
# Run the standard workflow for visualization and clustering
seurat_integrated <- RunPCA(object = seurat_integrated, npcs = 40, verbose = F)
ElbowPlot(seurat_integrated, ndims = 40)
PCAPlot(seurat_integrated) 
seurat_integrated <- RunUMAP(seurat_integrated,
dims = 1:40,
reduction = "pca")## Warning: The default method for RunUMAP has changed from calling Python UMAP via reticulate to the R-native UWOT using the cosine metric
## To use Python UMAP via reticulate, set umap.method to 'umap-learn' and metric to 'correlation'
## This message will be shown once per session## 21:55:03 UMAP embedding parameters a = 0.9922 b = 1.112## 21:55:03 Read 14159 rows and found 40 numeric columns## 21:55:03 Using Annoy for neighbor search, n_neighbors = 30## 21:55:03 Building Annoy index with metric = cosine, n_trees = 50## 0% 10 20 30 40 50 60 70 80 90 100%## [----|----|----|----|----|----|----|----|----|----|## **************************************************|
## 21:55:06 Writing NN index file to temp file C:\Users\Dell\AppData\Local\Temp\RtmpeQtSH1\file490c291d7ca1
## 21:55:06 Searching Annoy index using 1 thread, search_k = 3000
## 21:55:10 Annoy recall = 100%
## 21:55:11 Commencing smooth kNN distance calibration using 1 thread with target n_neighbors = 30
## 21:55:13 Initializing from normalized Laplacian + noise (using irlba)
## 21:55:13 Commencing optimization for 200 epochs, with 627670 positive edges
## 21:55:28 Optimization finishedseurat_integrated <- RunTSNE(seurat_integrated,
reduction = "pca")
# Determine the K-nearest neighbor graph
seurat_integrated <- FindNeighbors(object = seurat_integrated,
dims = 1:40)## Computing nearest neighbor graph
## Computing SNN# Determine the clusters for various resolutions
seurat_integrated <- FindClusters(object = seurat_integrated,
resolution = c(0.05, 0.5))## Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
##
## Number of nodes: 14159
## Number of edges: 522300
##
## Running Louvain algorithm...
## Maximum modularity in 10 random starts: 0.9825
## Number of communities: 11
## Elapsed time: 2 seconds
## Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
##
## Number of nodes: 14159
## Number of edges: 522300
##
## Running Louvain algorithm...
## Maximum modularity in 10 random starts: 0.9360
## Number of communities: 22
## Elapsed time: 2 seconds#saveRDS(seurat_integrated, "Seurat_integrated_twobrainsample_09052022.RDS")Clustering quality control
This step gives us some idea about how is the distribution of the number of genes, number of UMIs, and percentage of mitochondrial genes in each cluster. Normally, we expect to see similar distribution of no. of genes (nFeature_RNA) and no. of UMIs (nCount_RNA).
As for the percent.mt (percentage of mitochondrial genes per cell), it can be a reference to check if those high intensity clusters might be having poor quality cells (if so, we can try to remove in the next step or adjust the metrics in the previous filtering step) or it might be due to the differences biologically
DefaultAssay(seurat_integrated) <- "integrated"
# Determine metrics to plot present in seurat_integrated@meta.data
# NOTE from SQ: for certain feature if not found in 'integrated' assay (may only have 2000 high variable features), you may need to switch to "RNA" or "SCT" assay using DefaultAssay(seurat_integrated) <- "RNA"
metrics <- c("nFeature_RNA", "nCount_RNA", "percent.mt")
png(file = "./v1_output/QC_Featureplot_after.png", width = 1000, height = 800)
FeaturePlot(seurat_integrated,
reduction = "umap",
features = metrics,
split.by = "sample.id",
pt.size = 0.4,
min.cutoff = 'q10',
label = TRUE)
dev.off()## png
## 2Find all markers in two samples for cell type identification
Idents(seurat_integrated)<- "seurat_clusters"
gallitano.markers <- FindAllMarkers(seurat_integrated,
only.pos=TRUE, min.pct=0.25, logfc.threshold=0.25)## Calculating cluster 0## For a more efficient implementation of the Wilcoxon Rank Sum Test,
## (default method for FindMarkers) please install the limma package
## --------------------------------------------
## install.packages('BiocManager')
## BiocManager::install('limma')
## --------------------------------------------
## After installation of limma, Seurat will automatically use the more
## efficient implementation (no further action necessary).
## This message will be shown once per session## Calculating cluster 1## Calculating cluster 2## Calculating cluster 3## Calculating cluster 4## Calculating cluster 5## Calculating cluster 6## Calculating cluster 7## Calculating cluster 8## Calculating cluster 9## Calculating cluster 10## Calculating cluster 11## Calculating cluster 12## Calculating cluster 13## Calculating cluster 14## Calculating cluster 15## Calculating cluster 16## Calculating cluster 17## Calculating cluster 18## Calculating cluster 19## Calculating cluster 20## Calculating cluster 21write.csv(gallitano.markers, "./v1_output/gallitano_markers_20220226.csv")plotting top markers for each cluster
# setting up plotting parameters
getPalette = colorRampPalette(brewer.pal(8, "Set2"))
Idents(seurat_integrated)<- "seurat_clusters"
y <- gallitano.markers %>% group_by(cluster) %>% top_n(n = 1, wt = avg_log2FC)
v2 <- VlnPlot(seurat_integrated, assay = "RNA", features = y$gene, stack = TRUE, flip = TRUE) + NoLegend() +stat_summary(fun=median, geom="point", size=0.5, color="black")
# v2 + scale_fill_manual(values = getPalette(length(y$gene)))
ggsave("./v1_output/top_gene_marker_all_cluster.png", width = 6, height = 6)
rm(v2)
v3 <- VlnPlot(seurat_integrated, assay = "RNA", features = "Map2k1") +NoLegend()
#v3 <- VlnPlot(seurat_integrated, assay = "RNA", features = c("Foxp2", "Kcnab3"))
v3$layers[[2]]$aes_params$alpha <- 0.1
ggsave("./v1_output/single_gene_vln.png", width = 10, height = 2.8)
v3_2 <- VlnPlot(seurat_integrated, assay = "RNA", idents = c(0,1,13,4,5,9), features = "Mapk1", split.by = "group.id") #split.plot = TRUE## The default behaviour of split.by has changed.
## Separate violin plots are now plotted side-by-side.
## To restore the old behaviour of a single split violin,
## set split.plot = TRUE.
##
## This message will be shown once per session.v3_2$layers[[2]]$aes_params$alpha <- 0.1
ggsave("./v1_output/single_gene_vln_by_cluster.png", width = 10, height = 2.8)
rm(v3, v3_2)
# VlnPlot(seurat_integrated, features = y$gene[1:10], stack = TRUE)
v4 <- FeaturePlot(seurat_integrated, features = y$gene[1:9]) # top 1 gene marker for the first 9 cluster
ggsave("./v1_output/featurePlot_topGene_each_cluster.png", width = 10, height = 10)
rm(v4)
v5 <- FeaturePlot(seurat_integrated, features = y$gene[1:2], blend = TRUE)
ggsave("./v1_output/blend_featureplot_top2_genes.png", width = 10, height = 3)
rm(v5)
top5 <- gallitano.markers %>% group_by(cluster) %>% top_n(n = 5, wt = avg_log2FC)
v9 <- DoHeatmap(seurat_integrated, features = top5$gene) + NoLegend()
ggsave("./v1_output/heatmap_top5Gene_each_cluster.png", width = 10, height = 6)
rm(v9)define genes of interest
select_genes = c('Trem2','Snap25','Epas1', 'Egr1', 'Npas4', 'Calcrl', 'Map2k1', 'Mapk1', 'Mapk3')
select_genes2 <- c('Snap25','Gad1','Gad2', 'Slc32a1', 'Slc17a7', 'Lamp5', 'Aqp4', 'Gfap', "Ndnf", 'Sncg', 'Vip', 'Trem2','Sst','Pvalb', 'Cux2', 'Rorb', 'Fezf2', 'Foxp2', 'Npas4', 'Mbp', 'Cldn5', 'Ctss', 'C1qa','Map2k1', 'Mapk1', 'Mapk3')
Idents(seurat_integrated) <- "seurat_clusters" # seurat_integrated$integrated_snn_res.0.05
cellRanks <- seurat_integrated@meta.data[order(seurat_integrated@meta.data$seurat_clusters),] # check cellRanks structure!
PartialMatrix <- seurat_integrated@assays$integrated@scale.data[which(rownames(seurat_integrated@assays$integrated@scale.data) %in% select_genes2), rownames(cellRanks)]
cellRanks$col <- rainbow(max(as.numeric(cellRanks$seurat_clusters))+1)[as.numeric(cellRanks$seurat_clusters)+1]
#
ha_column <- HeatmapAnnotation(
df = data.frame(
ClusterID = as.numeric(cellRanks$seurat_clusters)
),
col = list(
ClusterID = colorRamp2(unique(as.numeric(cellRanks$seurat_clusters)),
rainbow(max(as.numeric(cellRanks$seurat_clusters))))
)
)
png(file = "./v1_output/select_geneset_heatmap.png", width = 1000, height = 400)
ht1 = Heatmap(PartialMatrix, name = "Scaled\nUMI", column_title = "Allen SMARTseq dataset genes",
top_annotation = ha_column, show_column_names=FALSE, cluster_columns = FALSE,
row_names_gp = gpar(fontsize = 16))## `use_raster` is automatically set to TRUE for a matrix with more than
## 2000 columns You can control `use_raster` argument by explicitly
## setting TRUE/FALSE to it.
##
## Set `ht_opt$message = FALSE` to turn off this message.## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.# do not use TRUE for clustering, too many cells cannot see clearly
ht1
# ht1
dev.off()## png
## 2png(file = "./v1_output/heatmap_groupby_seurat_clusters.png", width = 1000, height = 500)
DoHeatmap(seurat_integrated, features = select_genes2, group.by = 'seurat_clusters' ) + NoLegend()## Warning in DoHeatmap(seurat_integrated, features = select_genes2, group.by =
## "seurat_clusters"): The following features were omitted as they were not found
## in the scale.data slot for the integrated assay: Mapk3, Mapk1, Map2k1, Npas4,
## Fezf2, Rorb, Cux2, Vip, Ndnf, Lamp5, Slc32a1, Gad2, Gad1#DoHeatmap(subset(seurat_integrated, downsample =100), features = select_genes2, group.by = 'seurat_clusters' ) + NoLegend()
dev.off()## png
## 2png(file = "./v1_output/heatmap_noCluster_fancyColor.png", width = 1000, height = 500)
mapal <- colorRampPalette(RColorBrewer::brewer.pal(11,"RdBu"))(256)
DoHeatmap(seurat_integrated, features = select_genes2, angle = 90, size = 3) + scale_fill_gradientn(colours = rev(mapal))## Warning in DoHeatmap(seurat_integrated, features = select_genes2, angle = 90, :
## The following features were omitted as they were not found in the scale.data
## slot for the integrated assay: Mapk3, Mapk1, Map2k1, Npas4, Fezf2, Rorb, Cux2,
## Vip, Ndnf, Lamp5, Slc32a1, Gad2, Gad1## Scale for fill is already present.
## Adding another scale for fill, which will replace the existing scale.dev.off()## png
## 2png(file = "./v1_output/heatmap_noCluster_fancyColor_nCells.png", width = 1000, height = 500)
DoHeatmap(subset(seurat_integrated, downsample = 200), features = select_genes2, angle = 90, size = 3) + scale_fill_gradientn(colours = rev(mapal))## Warning in DoHeatmap(subset(seurat_integrated, downsample = 200), features =
## select_genes2, : The following features were omitted as they were not found in
## the scale.data slot for the integrated assay: Mapk3, Mapk1, Map2k1, Npas4,
## Fezf2, Rorb, Cux2, Vip, Ndnf, Lamp5, Slc32a1, Gad2, Gad1## Scale for fill is already present.
## Adding another scale for fill, which will replace the existing scale.dev.off()## png
## 2#Heatmap(subset(seurat_integrated, downsample = 200), features = select_genes2, angle = 90, size = 3) + scale_fill_gradientn(colours = rev(mapal))
png(file = "./v1_output/Vlnplot4selectedFeatures.png", width = 1000, height = 300)
plot <- VlnPlot(seurat_integrated, assay = "RNA", features = c("Map2k1","Trem2"), combine = FALSE, fill.by = c("feature","ident"))
plot <- lapply(
X = plot,
FUN = function(p) p + aes(color= seurat_integrated$integrated_snn_res.0.05)
)
# plot$layers[[2]]$aes_params$alpha <- 0.1
CombinePlots(plots = plot, legend = 'none')## Warning: CombinePlots is being deprecated. Plots should now be combined using
## the patchwork system.## Warning: Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.
## Groups with fewer than two data points have been dropped.dev.off()## png
## 2Find markers for specific cluster in two samples for cell type identification
Idents(seurat_integrated)<- "seurat_clusters"
cluster1.markers <- FindMarkers(seurat_integrated, ident.1 = 1, min.pct = 0.25, only.pos = TRUE) #compare cluster1 with all the rest of clusters
head(cluster1.markers, n = 5)## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Camp 0 0.2959546 0.257 0.073 0
## Igfbp4 0 0.7948736 0.128 0.284 0
## Retnlg 0 0.5257868 0.260 0.036 0
## Cacng8 0 1.3460899 0.268 0.076 0
## Gm35188 0 0.9190627 0.281 0.075 0png(file = "./v1_output/cluster1_marker_top15.png", width = 800, height = 1000)
v1 <- VlnPlot(seurat_integrated, assay = "RNA", features = row.names(cluster1.markers)[1:15], stack = TRUE, flip = TRUE)
#v1
v1+stat_summary(fun=median, geom="point", size=1, color="black")
#getPalette = colorRampPalette(brewer.pal(9, "Set1")) #11 is max for RdBu
v1 + scale_fill_manual(values = getPalette(15))+stat_summary(fun=median, geom="point", size=0.5, color="black")
#v1 + scale_fill_brewer(palette="RdBu")
dev.off()## png
## 2ggsave("./v1_output/cluster1_marker_top15_mean_custom_palette.pdf", width = 8, height = 8)
png(file = "./v1_output/cluster1_marker_top5_split.png", width = 800, height = 600)
VlnPlot(seurat_integrated, assay = "RNA", features = row.names(cluster1.markers)[1:5], stack = TRUE, flip = TRUE, split.by = "group.id", split.plot = TRUE)
dev.off()## png
## 2ggsave("./v1_output/cluster1_marker_top5_split.pdf", width = 8, height = 6)
#p1 <- VlnPlot(seurat_integrated, assay = "RNA", features = row.names(cluster1.markers)[1:5], pt.size = 0, stack = TRUE, flip = TRUE)
## p1$layers[[1]]$aes_params$alpha <- 0.1 #does not work
#p1
cluster2.markers <- FindMarkers(seurat_integrated, ident.1 = 2, ident.2 = c(3,4), min.pct = 0.25, only.pos = TRUE) #compare cluster2 with clusters 3 and 4
v1 <- VlnPlot(seurat_integrated, assay = "RNA", features = row.names(cluster2.markers)[1:15], stack = TRUE, flip = TRUE)
ggsave("./v1_output/cluster2_marker_top15.pdf", width = 6, height = 6)
rm(v1)
y <- gallitano.markers %>% group_by(cluster) %>% top_n(n = 1, wt = avg_log2FC)
v2 <- VlnPlot(seurat_integrated, assay = "RNA", features = y$gene, stack = TRUE, flip = TRUE) +stat_summary(fun=median, geom="point", size=1, color="black") + scale_fill_manual(values = getPalette(26))+stat_summary(fun=median, geom="point", size=0.5, color="black") + NoLegend() #getPalette(length(y$gene))
ggsave("./v1_output/top_gene_marker_all_cluster.png", width = 6, height = 6)
rm(v2)plotting cell type specific markers
Idents(object = seurat_integrated) <- 'seurat_clusters'
# Astrocyte markers
png(filename = "./v1_output/astrocyte_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, assay = "RNA", features =c("Aqp4","Prdx6","Pla2g7"))
dev.off()## png
## 2# Plotting Microglia Markers
png(filename = "./v1_output/microglia_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, assay = "RNA", features =c("C1qc","Ly86", "Tmem119"))
dev.off()## png
## 2# Plotting Endothelial Markers
png(filename = "./v1_output/endothelial_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, assay = "RNA", features =c("Ly6a", "Ly6c1", "Pltp"))
dev.off()## png
## 2# Plotting Oligodendrocyte Markers
png(filename = "./v1_output/oligoDC_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, assay = "RNA", features =c("Mag", "Mbp", "Cldn11"))
dev.off()## png
## 2# Plotting Glutamatergic Neuron Markers
png(filename = "./v1_output/Glutamatergic_Neuron_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, assay = "RNA", features =c("Nrgn", "Sv2b", "Snap25"))
dev.off()## png
## 2# Plotting Gabaergic Neuron Markers
png(filename = "./v1_output/Gabaergic_Neuron_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, assay = "RNA", features =c("Gad1", "Gad2", "Rab3b" ))## Warning in FetchData.Seurat(object = object, vars = features, slot = slot): The
## following requested variables were not found: Gad2dev.off()## png
## 2# Plotting Oligodendrocyte Precursor Markers
png(filename = "./v1_output/OligoDC_Precursor_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, assay = "RNA", features =c("Pdgfra", "Cspg4", "Gm2a"))
dev.off()## png
## 2Identifying cell type
Option 1: SingleR package with built-in reference
I use a collection of mouse bulk RNA-seq data sets obtained from celldex package (Benayoun et al. 2019). A variety of cell types are available, mostly from blood but also covering several other tissues. This identifies marker genes from the reference and uses them to compute assignment scores (based on the Spearman correlation across markers) for each cell in the test dataset against each label in the reference. The label with the highest score is the assigned to the test cell, possibly with further fine-tuning to resolve closely related labels.
This reference consists of a collection of mouse bulk RNA-seq data sets downloaded from the gene expression omnibus (Benayoun et al. 2019). A variety of cell types are available, again mostly from blood but also covering several other tissues.
#BiocManager::install("SingleR")
#BiocManager::install("celldex")
library(SingleR)##
## Attaching package: 'SingleR'## The following objects are masked from 'package:celldex':
##
## BlueprintEncodeData, DatabaseImmuneCellExpressionData,
## HumanPrimaryCellAtlasData, ImmGenData, MonacoImmuneData,
## MouseRNAseqData, NovershternHematopoieticDatalibrary(celldex)
ref <- MouseRNAseqData()## Warning: 'MouseRNAseqData' is deprecated.
## Use 'celldex::MouseRNAseqData' instead.
## See help("Deprecated")## snapshotDate(): 2022-10-31## see ?celldex and browseVignettes('celldex') for documentation## loading from cache## see ?celldex and browseVignettes('celldex') for documentation## loading from cachetable(Idents(object = seurat_integrated))##
## 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
## 3565 1659 1078 926 858 783 666 567 563 534 504 407 374 347 285 239
## 16 17 18 19 20 21
## 203 199 126 108 94 74hpca.se <- SingleR(test = seurat_integrated@assays$RNA@data, ref = ref,
labels = ref$label.main)
png(filename = "./v1_output/plotScoreHeatmap_m10.png",
width = 600, height = 500)
p1 <- plotScoreHeatmap(hpca.se)
dev.off() #need to be null device 1 in order for png to finish## png
## 3png(filename = "./v1_output/plotDeltaDistribution_m10.png",
width = 1000, height = 1400)
plotDeltaDistribution(hpca.se, ncol = 3)## Warning: Groups with fewer than two data points have been dropped.## Warning in max(data$density): no non-missing arguments to max; returning -Inf## Warning: Computation failed in `stat_ydensity()`
## Caused by error in `$<-.data.frame`:
## ! replacement has 1 row, data has 0## Warning: Groups with fewer than two data points have been dropped.## Warning in max(data$density): no non-missing arguments to max; returning -Inf## Warning: Computation failed in `stat_ydensity()`
## Caused by error in `$<-.data.frame`:
## ! replacement has 1 row, data has 0## Warning: Groups with fewer than two data points have been dropped.## Warning in max(data$density): no non-missing arguments to max; returning -Inf## Warning: Computation failed in `stat_ydensity()`
## Caused by error in `$<-.data.frame`:
## ! replacement has 1 row, data has 0dev.off()## png
## 3all.markers <- metadata(hpca.se)$de.genes
seurat_integrated$labels_hpca <- hpca.se$labels
# Extract identity and sample information from seurat object to determine the number of cells per cluster per sample
n_cells <- FetchData(seurat_integrated,
vars = c("integrated_snn_res.0.5",
"labels_hpca")) %>%
dplyr::count(integrated_snn_res.0.5,
labels_hpca) %>%
tidyr::spread(integrated_snn_res.0.5, n)
View(n_cells)
write.csv(n_cells, "./v1_output/n_cells_mouseRNAseqData_onesample.csv")
## comparing with the unsupervised clustering
tab <- table(cluster= seurat_integrated$integrated_snn_res.0.5, label= hpca.se$labels)
png(filename = "./v1_output/pheatmap_SingleR_m10.png",
width = 600, height = 500)
p3 <- pheatmap::pheatmap(log10(tab+10))
p3
dev.off()## png
## 3Option 2: manual annotation
Plotting Astrocyte Markers
png(filename = "./v1_output/astrocyte_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, features =c("Aqp4","Prdx6","Pla2g7"))## Warning: Found the following features in more than one assay, excluding the
## default. We will not include these in the final data frame: Prdx6, Pla2g7## Warning in FetchData.Seurat(object = object, vars = features, slot = slot): The
## following requested variables were not found: Prdx6, Pla2g7dev.off()## png
## 2Plotting Microglia Markers
png(filename = "./v1_output/microglia_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, features =c("C1qc","Ly86", "Tmem119", "Trem2"))
dev.off()## png
## 2Plotting Endothelial Markers
png(filename = "./v1_output/endothelial_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, features =c("Ly6a", "Ly6c1", "Pltp"))
dev.off()## png
## 2Plotting Oligodendrocyte Markers
png(filename = "./v1_output/oligoDC_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, features =c("Mag", "Mbp", "Cldn11"))
dev.off()## png
## 2Plotting Glutamatergic Neuron Markers
png(filename = "./v1_output/Glutamatergic_Neuron_marker_score.png", width = 1500, height = 400)
VlnPlot(object = seurat_integrated, features =c("Nrgn", "Sv2b", "Snap25"))## Warning: Found the following features in more than one assay, excluding the
## default. We will not include these in the final data frame: Nrgn## Warning in FetchData.Seurat(object = object, vars = features, slot = slot): The
## following requested variables were not found: Nrgndev.off()## png
## 2Plotting Gabaergic Neuron Markers
Plotting Oligodendrocyte Precursor Markers
saveRDS(seurat_integrated, "./v1_output/seurat_integrated_twobrainsamples_12052022.RDS")Rename cluster based on the SingleR results and manual annotation
seurat_integrated <- RenameIdents(object = seurat_integrated,
"0" = "Glut_N",
"1" = "Glut_N",
"2" = "Glut_N",
"3" = "Glut_N",
"4" = "Endo",
"5" = "Glut_N",
"6" = "Glut_N",
"7" = "Glut_N",
"8" = "Glut_N",
"9" = "Astro",
"10" = "GABA_N",
"11" = "Astro",
"12" = "GABA_N",
"13" = "Glut_N",
"14" = "Oligo",
"15" = "GABA_N",
"16" = "GABA_N",
"17" = "Glut_N",
"18" = "OPC",
"19" = "Oligo",
"20" = "Micro",
"21" = "OPC",
"22" = "un-ID",
"23" = "Glut_N"
)## Warning: Cannot find identity 23## Warning: Cannot find identity 22seurat_integrated$celltype_LC <- seurat_integrated@active.ident
png(filename = "./v2_output/UMAP_res0.5_samples.png",
width = 1200, height = 500)
DimPlot(seurat_integrated,
reduction = "umap",
group.by = "integrated_snn_res.0.5",
split.by = "sample.id",
label = TRUE,
)
dev.off()## png
## 2Idents(object = seurat_integrated) <- "celltype_LC"
plot <- DimPlot(seurat_integrated,
reduction = "umap",
group.by = "celltype_LC",
label = FALSE,
)
plot$data$seurat_clusters <- seurat_integrated@meta.data$integrated_snn_res.0.5
all(rownames(plot$data) == rownames(seurat_integrated@meta.data))## [1] TRUEpng(filename = "./v2_output/UMAP_res0.5_celltype_LC.png",
width = 400, height = 400)
LabelClusters(plot, id = "celltype_LC")
dev.off()## png
## 2ggsave("./v2_output/UMAP_res0.5_celltype_LC.pdf", width = 6, height = 6)
Idents(object = seurat_integrated) <- "celltype_LC"
plot <- DimPlot(seurat_integrated,
reduction = "umap",
group.by = "celltype_LC",
split.by = "sample.id",
label = FALSE,
)
plot$data$seurat_clusters <- seurat_integrated@meta.data$integrated_snn_res.0.5
all(rownames(plot$data) == rownames(seurat_integrated@meta.data))## [1] TRUEpng(filename = "./v2_output/UMAP_res0.5_celltype_LC_sample.png",
width = 1200, height = 500)
LabelClusters(plot, id = "seurat_clusters")
dev.off()## png
## 2saveRDS(seurat_integrated, "./v2_output/seurat_integrated_twobrainsamples_09052022.RDS")Option 3: manual annotation; can skip this
Refer to Tasic et al, Nature 2018, marker list https://github.com/AllenInstitute/tasic2018analysis/blob/master/RNA-seq%20Analysis/markers.R
Differential expression Analysis for groups
Now we do a DEG analysis for all genes between the two groups
## [[1]]
## p_val avg_log2FC pct.1 pct.2 p_val_adj comparison
## Hormad1 0.000000e+00 3.3714584 0.049 0.266 0.000000e+00 CTL_TRT
## Slc6a16 0.000000e+00 3.2673265 0.019 0.198 0.000000e+00 CTL_TRT
## Gm50115 0.000000e+00 2.6092127 0.012 0.371 0.000000e+00 CTL_TRT
## Tmem61 0.000000e+00 2.7053128 0.017 0.242 0.000000e+00 CTL_TRT
## Ddx11 0.000000e+00 2.4169245 0.025 0.337 0.000000e+00 CTL_TRT
## Lin9 0.000000e+00 3.4530193 0.030 0.330 0.000000e+00 CTL_TRT
## Gm47080 0.000000e+00 2.9328015 0.043 0.201 0.000000e+00 CTL_TRT
## F12 0.000000e+00 3.2348693 0.035 0.249 0.000000e+00 CTL_TRT
## Exoc3l2 0.000000e+00 0.8073481 0.011 0.248 0.000000e+00 CTL_TRT
## 4930438E09Rik 0.000000e+00 1.3552695 0.016 0.267 0.000000e+00 CTL_TRT
## D930020B18Rik 0.000000e+00 1.6186732 0.031 0.274 0.000000e+00 CTL_TRT
## Gm973 0.000000e+00 0.8702813 0.023 0.274 0.000000e+00 CTL_TRT
## Pbld1 0.000000e+00 2.2386870 0.072 0.262 0.000000e+00 CTL_TRT
## Hopxos 0.000000e+00 2.9376764 0.048 0.220 0.000000e+00 CTL_TRT
## F630040K05Rik 0.000000e+00 1.8568304 0.033 0.316 0.000000e+00 CTL_TRT
## Stk31 0.000000e+00 1.1856377 0.010 0.214 0.000000e+00 CTL_TRT
## Hsd17b3 0.000000e+00 3.0333115 0.025 0.259 0.000000e+00 CTL_TRT
## Gm47889 0.000000e+00 3.7698632 0.017 0.225 0.000000e+00 CTL_TRT
## Tex15 0.000000e+00 1.7137170 0.009 0.227 0.000000e+00 CTL_TRT
## Shcbp1l 0.000000e+00 2.7323244 0.021 0.248 0.000000e+00 CTL_TRT
## Proc 0.000000e+00 1.9314813 0.017 0.192 0.000000e+00 CTL_TRT
## Gm28156 0.000000e+00 0.9905373 0.006 0.170 0.000000e+00 CTL_TRT
## Asb18 0.000000e+00 2.3314607 0.067 0.239 0.000000e+00 CTL_TRT
## Ttc39d 0.000000e+00 2.4178580 0.008 0.216 0.000000e+00 CTL_TRT
## Asic4 0.000000e+00 1.5479130 0.033 0.243 0.000000e+00 CTL_TRT
## Aif1 0.000000e+00 3.3001585 0.021 0.217 0.000000e+00 CTL_TRT
## Ccdc63 0.000000e+00 1.9329144 0.047 0.310 0.000000e+00 CTL_TRT
## Filip1l 0.000000e+00 2.8605667 0.011 0.136 0.000000e+00 CTL_TRT
## Gm13684 0.000000e+00 3.5418052 0.004 0.107 0.000000e+00 CTL_TRT
## 1700025F24Rik 0.000000e+00 2.1359733 0.010 0.235 0.000000e+00 CTL_TRT
## B4galnt2 0.000000e+00 2.1138802 0.029 0.289 0.000000e+00 CTL_TRT
## Glp2r 0.000000e+00 2.0667281 0.001 0.113 0.000000e+00 CTL_TRT
## Tpcn2 3.465130e-306 3.8704924 0.032 0.248 1.039539e-302 CTL_TRT
## Lamb3 3.311282e-303 1.9765143 0.020 0.285 9.933846e-300 CTL_TRT
## Polh 1.693408e-302 2.2768219 0.043 0.263 5.080224e-299 CTL_TRT
## Gm32857 5.653635e-300 2.0174792 0.032 0.272 1.696090e-296 CTL_TRT
## Smpdl3b 9.511449e-298 1.6597950 0.028 0.225 2.853435e-294 CTL_TRT
## Acat3 1.459483e-293 1.6400763 0.039 0.337 4.378448e-290 CTL_TRT
## B430212C06Rik 3.760474e-293 2.6683642 0.062 0.284 1.128142e-289 CTL_TRT
## B230323A14Rik 1.935198e-291 1.9032519 0.020 0.196 5.805593e-288 CTL_TRT
## Gm16675 1.820428e-285 2.3333561 0.011 0.228 5.461285e-282 CTL_TRT
## Slamf1 1.858269e-285 3.6029867 0.032 0.285 5.574807e-282 CTL_TRT
## Terb2 7.471072e-285 2.8430524 0.009 0.210 2.241322e-281 CTL_TRT
## Gm36266 2.083736e-281 1.2270956 0.079 0.259 6.251209e-278 CTL_TRT
## Knl1 4.935884e-280 1.9974197 0.035 0.321 1.480765e-276 CTL_TRT
## Dnaaf1 1.083708e-279 4.3407529 0.010 0.136 3.251125e-276 CTL_TRT
## C920021L13Rik 3.969745e-279 3.0962191 0.033 0.349 1.190924e-275 CTL_TRT
## Fancd2 4.680220e-277 2.8027762 0.023 0.294 1.404066e-273 CTL_TRT
## Gm26612 4.543565e-276 4.3412986 0.004 0.188 1.363070e-272 CTL_TRT
## 1700066B19Rik 4.767368e-276 1.3610709 0.008 0.263 1.430210e-272 CTL_TRT
## Platr7 5.175221e-276 1.2954664 0.013 0.268 1.552566e-272 CTL_TRT
## Retn 7.034690e-274 3.1250524 0.006 0.197 2.110407e-270 CTL_TRT
## Slc5a4b 1.069714e-273 3.3135282 0.023 0.275 3.209141e-270 CTL_TRT
## Meikin 2.135066e-270 2.7438964 0.036 0.227 6.405198e-267 CTL_TRT
## 4921524L21Rik 2.529645e-269 2.3515278 0.070 0.188 7.588936e-266 CTL_TRT
## Gm8257 4.486143e-269 2.4346099 0.036 0.155 1.345843e-265 CTL_TRT
## Gm42884 1.877266e-268 2.1963549 0.021 0.274 5.631799e-265 CTL_TRT
## 4930477G07Rik 1.273779e-267 2.7711744 0.007 0.200 3.821338e-264 CTL_TRT
## Olfr1423 1.539070e-267 3.0737773 0.064 0.134 4.617210e-264 CTL_TRT
## Myh3 1.623941e-267 3.3080289 0.039 0.271 4.871824e-264 CTL_TRT
## Zscan10 1.052338e-266 1.8992339 0.099 0.198 3.157014e-263 CTL_TRT
## Hnf4aos 3.196850e-266 3.4608233 0.066 0.180 9.590550e-263 CTL_TRT
## Gm47465 1.238693e-264 2.7635044 0.014 0.198 3.716079e-261 CTL_TRT
## 4930469B13Rik 7.257760e-264 0.9923286 0.020 0.220 2.177328e-260 CTL_TRT
## Dmbx1 1.130623e-263 3.9967601 0.045 0.179 3.391869e-260 CTL_TRT
## Gm32913 2.688268e-262 1.2413825 0.013 0.255 8.064805e-259 CTL_TRT
## Mmrn1 9.482794e-262 3.3700300 0.031 0.199 2.844838e-258 CTL_TRT
## Abo 1.207675e-260 2.8958244 0.028 0.138 3.623026e-257 CTL_TRT
## Lamc2 1.177901e-258 3.0603339 0.036 0.203 3.533702e-255 CTL_TRT
## Col13a1 1.302721e-258 0.6943413 0.029 0.192 3.908162e-255 CTL_TRT
## Gm13822 5.463861e-256 2.3267017 0.067 0.200 1.639158e-252 CTL_TRT
## Acp7 3.467941e-253 2.7489749 0.017 0.167 1.040382e-249 CTL_TRT
## Gm9195 1.444542e-250 4.1096699 0.023 0.161 4.333627e-247 CTL_TRT
## Fkbp6 1.067183e-248 1.7192038 0.034 0.268 3.201549e-245 CTL_TRT
## Tnfrsf9 3.881821e-248 1.3324488 0.021 0.156 1.164546e-244 CTL_TRT
## Tas1r1 1.431410e-247 0.7259049 0.026 0.214 4.294230e-244 CTL_TRT
## 4930509E16Rik 1.308102e-244 2.3023456 0.053 0.225 3.924307e-241 CTL_TRT
## Cd83 7.287807e-244 1.1163793 0.032 0.159 2.186342e-240 CTL_TRT
## Alpk2 3.045098e-242 1.7037159 0.033 0.258 9.135293e-239 CTL_TRT
## Gm36431 2.464358e-241 1.1732576 0.032 0.189 7.393074e-238 CTL_TRT
## 2700038G22Rik 3.099100e-241 3.5719711 0.023 0.244 9.297301e-238 CTL_TRT
## Gm49313 6.562257e-241 3.2501926 0.080 0.204 1.968677e-237 CTL_TRT
## Plxdc1 7.083097e-241 4.3879740 0.061 0.203 2.124929e-237 CTL_TRT
## Hhla1 5.204642e-238 2.1246842 0.019 0.282 1.561393e-234 CTL_TRT
## Gm16618 6.663853e-236 2.8601397 0.024 0.285 1.999156e-232 CTL_TRT
## Gm17657 7.040543e-236 2.2664193 0.003 0.214 2.112163e-232 CTL_TRT
## Xlr5a 1.191725e-235 2.6331550 0.030 0.210 3.575174e-232 CTL_TRT
## Slc15a1 5.177359e-234 2.5336378 0.045 0.124 1.553208e-230 CTL_TRT
## Ccl2 5.295650e-233 1.0778502 0.139 0.221 1.588695e-229 CTL_TRT
## Gm2762 9.537113e-233 1.6800485 0.019 0.228 2.861134e-229 CTL_TRT
## Gm37459 1.415311e-232 4.7182685 0.007 0.159 4.245933e-229 CTL_TRT
## Rxfp1 2.064952e-231 2.4137333 0.090 0.232 6.194855e-228 CTL_TRT
## Scnn1a 3.518473e-231 3.0294318 0.040 0.251 1.055542e-227 CTL_TRT
## Wee2 2.207620e-230 2.6194725 0.012 0.181 6.622859e-227 CTL_TRT
## Gm43409 1.070938e-228 1.8044544 0.061 0.181 3.212813e-225 CTL_TRT
## Ccl17 1.099742e-227 0.7303342 0.025 0.137 3.299226e-224 CTL_TRT
## Tex21 1.147655e-225 2.1944111 0.032 0.134 3.442966e-222 CTL_TRT
## Gm26594 3.035838e-225 4.1475050 0.031 0.267 9.107515e-222 CTL_TRT
## Klhl1 7.797325e-225 -1.0323848 0.028 0.132 2.339198e-221 CTL_TRT
## Zbtb46 2.108950e-224 4.6122242 0.119 0.231 6.326851e-221 CTL_TRT
## Cyp2ab1 2.888510e-224 3.1180172 0.005 0.141 8.665531e-221 CTL_TRT
## C130083M11Rik 7.926767e-223 1.7343679 0.016 0.147 2.378030e-219 CTL_TRT
## Ropn1 2.240756e-222 2.5558890 0.029 0.214 6.722269e-219 CTL_TRT
## 1700094D03Rik 7.262794e-219 4.3240343 0.019 0.284 2.178838e-215 CTL_TRT
## Cfap77 1.690968e-217 0.7793097 0.019 0.201 5.072903e-214 CTL_TRT
## Myo3a 3.756071e-217 2.3637224 0.009 0.151 1.126821e-213 CTL_TRT
## Dusp27 7.067840e-216 1.8084817 0.016 0.206 2.120352e-212 CTL_TRT
## Gm32004 7.772709e-216 2.2860065 0.034 0.200 2.331813e-212 CTL_TRT
## 4921504E06Rik 6.541096e-214 3.9916483 0.003 0.112 1.962329e-210 CTL_TRT
## Traip 6.582502e-213 3.3065966 0.049 0.226 1.974751e-209 CTL_TRT
## B230312C02Rik 1.101660e-212 2.6666798 0.163 0.265 3.304979e-209 CTL_TRT
## Gdf15 1.135292e-209 1.3418971 0.016 0.277 3.405876e-206 CTL_TRT
## Hkdc1 1.295425e-209 1.9105835 0.004 0.153 3.886275e-206 CTL_TRT
## Inhbc 1.580158e-209 4.3449758 0.044 0.118 4.740475e-206 CTL_TRT
## 1600002D24Rik 2.284312e-208 2.0622792 0.017 0.174 6.852937e-205 CTL_TRT
## Adamts2 2.807112e-208 3.4035975 0.098 0.166 8.421336e-205 CTL_TRT
## Zg16 4.730008e-208 2.0181259 0.015 0.207 1.419002e-204 CTL_TRT
## Mustn1 1.084268e-207 0.7837856 0.069 0.174 3.252804e-204 CTL_TRT
## Gm33843 8.591345e-207 2.5735137 0.066 0.176 2.577403e-203 CTL_TRT
## Armh1 2.549186e-206 0.8901657 0.018 0.245 7.647557e-203 CTL_TRT
## Alpk3 3.456626e-205 3.4519308 0.010 0.142 1.036988e-201 CTL_TRT
## Adgrd1 1.144368e-203 3.1727223 0.058 0.175 3.433104e-200 CTL_TRT
## 1700010K24Rik 1.341879e-203 4.1614466 0.024 0.206 4.025638e-200 CTL_TRT
## Gm49938 2.402798e-203 0.7855406 0.136 0.289 7.208394e-200 CTL_TRT
## Gm26885 3.853292e-203 2.5192615 0.034 0.264 1.155988e-199 CTL_TRT
## A530053G22Rik 3.513906e-202 2.8030571 0.016 0.146 1.054172e-198 CTL_TRT
## Aldh16a1 1.347178e-201 3.9430406 0.060 0.215 4.041533e-198 CTL_TRT
## Gm11715 1.948519e-201 2.4024122 0.046 0.144 5.845558e-198 CTL_TRT
## Magix 9.454365e-200 2.5148568 0.003 0.182 2.836310e-196 CTL_TRT
## Atp12a 3.118379e-198 1.9972030 0.062 0.262 9.355138e-195 CTL_TRT
## Gm14221 5.213225e-198 2.7293899 0.049 0.153 1.563967e-194 CTL_TRT
## Gm11290 5.261934e-198 2.4564870 0.131 0.218 1.578580e-194 CTL_TRT
## Rhd 1.038524e-197 1.9842554 0.025 0.167 3.115572e-194 CTL_TRT
## Gm50255 1.775859e-196 3.0507568 0.031 0.110 5.327576e-193 CTL_TRT
## Rasef 6.819974e-196 1.5554437 0.073 0.183 2.045992e-192 CTL_TRT
## Eef1akmt4 1.612777e-195 4.8501831 0.078 0.235 4.838330e-192 CTL_TRT
## Skap1 4.250314e-195 2.0267529 0.069 0.214 1.275094e-191 CTL_TRT
## Abcc3 8.014397e-195 3.2120018 0.034 0.162 2.404319e-191 CTL_TRT
## AC150683.1 3.734507e-193 3.7045220 0.063 0.242 1.120352e-189 CTL_TRT
## Pla2g10 1.243870e-192 2.3641491 0.048 0.193 3.731609e-189 CTL_TRT
## Gm4577 2.193725e-192 3.1807627 0.029 0.245 6.581176e-189 CTL_TRT
## Ankrd36 1.051887e-191 2.8076898 0.119 0.260 3.155662e-188 CTL_TRT
## Efcab6 1.325105e-191 3.9814847 0.027 0.218 3.975314e-188 CTL_TRT
## Tmbim7 1.632751e-191 2.9558544 0.009 0.130 4.898254e-188 CTL_TRT
## Gm20560 2.027727e-191 0.4527684 0.147 0.182 6.083180e-188 CTL_TRT
## 1700057H15Rik 3.304368e-191 4.0705790 0.014 0.113 9.913103e-188 CTL_TRT
## Clnk 7.931165e-191 3.6136810 0.057 0.260 2.379350e-187 CTL_TRT
## 2310039L15Rik 5.747600e-190 1.8494633 0.077 0.222 1.724280e-186 CTL_TRT
## Dnah8 7.692839e-190 0.4903648 0.010 0.264 2.307852e-186 CTL_TRT
## Gucy2g 1.015666e-189 2.2993065 0.005 0.225 3.046998e-186 CTL_TRT
## Plk4 3.558490e-189 4.1897097 0.112 0.295 1.067547e-185 CTL_TRT
## Atp2c2 3.837062e-189 2.2835533 0.032 0.138 1.151119e-185 CTL_TRT
## Cgn 8.642109e-189 1.9201494 0.035 0.227 2.592633e-185 CTL_TRT
## Cfap299 1.267590e-188 4.4555134 0.040 0.198 3.802771e-185 CTL_TRT
## Atp6v1c2 3.724949e-188 3.7355581 0.036 0.217 1.117485e-184 CTL_TRT
## Gm16158 8.686727e-188 2.3977237 0.033 0.182 2.606018e-184 CTL_TRT
## Nsun7 8.977803e-188 2.2459375 0.045 0.277 2.693341e-184 CTL_TRT
## Topaz1 1.041991e-187 4.4217716 0.043 0.180 3.125974e-184 CTL_TRT
## 1700041C23Rik 2.114927e-185 2.6059233 0.004 0.152 6.344780e-182 CTL_TRT
## Morc1 2.487264e-185 3.1656795 0.026 0.213 7.461792e-182 CTL_TRT
## Gm26787 2.685686e-185 3.9051370 0.027 0.176 8.057058e-182 CTL_TRT
## Gm32184 7.586818e-185 3.6987142 0.002 0.108 2.276046e-181 CTL_TRT
## Gm22146 3.282030e-184 2.0432949 0.058 0.123 9.846090e-181 CTL_TRT
## Arhgap30 5.228062e-184 -1.1663705 0.019 0.168 1.568419e-180 CTL_TRT
## Gm15839 5.824429e-184 4.6413678 0.004 0.114 1.747329e-180 CTL_TRT
## Kif28 1.640891e-183 3.0449906 0.051 0.214 4.922672e-180 CTL_TRT
## Vdr 3.561595e-183 2.8835095 0.007 0.156 1.068479e-179 CTL_TRT
## 1700034P13Rik 1.120902e-181 3.5395861 0.056 0.287 3.362706e-178 CTL_TRT
## Gm29585 2.332328e-181 2.6879186 0.101 0.199 6.996985e-178 CTL_TRT
## Sfta2 3.735656e-181 2.7494642 0.051 0.227 1.120697e-177 CTL_TRT
## Gm26737 1.054845e-180 3.7150213 0.033 0.253 3.164536e-177 CTL_TRT
## Plvap 3.359586e-180 -0.9467016 0.018 0.193 1.007876e-176 CTL_TRT
## Gm12766 4.661818e-179 2.1110910 0.044 0.219 1.398545e-175 CTL_TRT
## Kif4 3.698937e-178 1.5209845 0.011 0.164 1.109681e-174 CTL_TRT
## Cdca3 4.224389e-178 1.4350972 0.005 0.223 1.267317e-174 CTL_TRT
## 4933439K11Rik 4.860339e-178 2.6488364 0.014 0.204 1.458102e-174 CTL_TRT
## 4933424G05Rik 1.718449e-177 1.3744167 0.061 0.127 5.155346e-174 CTL_TRT
## Rhod 1.417801e-176 0.9504810 0.008 0.218 4.253404e-173 CTL_TRT
## Dqx1 3.762546e-176 3.9956034 0.041 0.235 1.128764e-172 CTL_TRT
## Cenpf 5.986514e-176 1.7704037 0.027 0.245 1.795954e-172 CTL_TRT
## Catsperd 1.537794e-175 3.4009724 0.083 0.186 4.613382e-172 CTL_TRT
## Hbb-bt 2.075719e-175 -0.4496718 0.058 0.150 6.227156e-172 CTL_TRT
## Ssc4d 3.513749e-175 2.7881531 0.080 0.202 1.054125e-171 CTL_TRT
## Tdrd12 3.687048e-175 2.5355805 0.009 0.190 1.106114e-171 CTL_TRT
## Cfap74 4.158322e-175 3.1601474 0.041 0.285 1.247496e-171 CTL_TRT
## Olfr1369-ps1 7.508368e-175 1.7645930 0.018 0.168 2.252510e-171 CTL_TRT
## 4930512B01Rik 9.924523e-175 3.8377836 0.085 0.199 2.977357e-171 CTL_TRT
## Gm49736 1.557850e-174 1.3813783 0.013 0.224 4.673549e-171 CTL_TRT
## Gm47782 2.585365e-174 3.3522974 0.031 0.231 7.756094e-171 CTL_TRT
## Gm34016 6.995705e-174 3.6457797 0.020 0.114 2.098712e-170 CTL_TRT
## Gm47944 9.961526e-174 3.1542766 0.075 0.162 2.988458e-170 CTL_TRT
## Gm26810 1.294769e-173 2.6927287 0.020 0.100 3.884307e-170 CTL_TRT
## Gm16599 1.440136e-173 4.7326976 0.026 0.123 4.320408e-170 CTL_TRT
## Gm34544 1.747408e-173 1.8993839 0.023 0.171 5.242223e-170 CTL_TRT
## 6430562O15Rik 4.442545e-172 2.1191302 0.007 0.314 1.332764e-168 CTL_TRT
## 1700082M22Rik 3.835340e-171 3.1452859 0.049 0.134 1.150602e-167 CTL_TRT
## Gm16555 4.560332e-171 3.8263065 0.102 0.148 1.368100e-167 CTL_TRT
## Gm16741 3.588127e-170 1.9428841 0.025 0.188 1.076438e-166 CTL_TRT
## Sag 8.187279e-170 1.7396225 0.134 0.251 2.456184e-166 CTL_TRT
## Gpx2 1.230595e-169 2.2216043 0.036 0.168 3.691785e-166 CTL_TRT
## Olfr1513 2.188134e-169 2.3779856 0.080 0.158 6.564401e-166 CTL_TRT
## Pkp1 2.288416e-169 3.9729029 0.050 0.255 6.865247e-166 CTL_TRT
## 4931415C17Rik 2.894345e-169 2.2782444 0.017 0.233 8.683035e-166 CTL_TRT
## Gm10550 6.378825e-169 4.6504599 0.046 0.144 1.913647e-165 CTL_TRT
## Xirp2 1.220688e-167 3.9030950 0.002 0.130 3.662065e-164 CTL_TRT
## 4732419C18Rik 5.417509e-166 1.8177590 0.044 0.179 1.625253e-162 CTL_TRT
## Cdh23 1.776543e-165 2.6281669 0.027 0.253 5.329628e-162 CTL_TRT
## Gm48742 5.619149e-163 2.0392695 0.016 0.167 1.685745e-159 CTL_TRT
## Akr1d1 1.623097e-162 3.7624045 0.113 0.179 4.869292e-159 CTL_TRT
## Slc28a1 4.792133e-162 3.2012235 0.049 0.202 1.437640e-158 CTL_TRT
## Sgk1 5.492969e-162 -1.0299761 0.153 0.219 1.647891e-158 CTL_TRT
## AY036118 1.296990e-161 3.0261934 0.054 0.260 3.890970e-158 CTL_TRT
## Antxr1 2.970439e-161 2.7411588 0.059 0.159 8.911318e-158 CTL_TRT
## Slc44a4 5.761176e-161 2.1082157 0.016 0.277 1.728353e-157 CTL_TRT
## Ephb1 1.550927e-160 2.7618400 0.026 0.142 4.652782e-157 CTL_TRT
## Il33 2.070078e-160 2.3313024 0.135 0.279 6.210233e-157 CTL_TRT
## A2m 2.241108e-160 1.6461229 0.039 0.238 6.723324e-157 CTL_TRT
## Ces1g 1.728465e-159 2.6552292 0.009 0.228 5.185394e-156 CTL_TRT
## Gm960 3.211994e-159 3.5458946 0.036 0.150 9.635983e-156 CTL_TRT
## Bub1b 3.001981e-158 1.8261113 0.089 0.185 9.005943e-155 CTL_TRT
## 1300017J02Rik 1.228370e-157 2.2486243 0.031 0.145 3.685111e-154 CTL_TRT
## Dnah3 1.506676e-157 2.4638983 0.009 0.236 4.520029e-154 CTL_TRT
## 4930415O20Rik 8.234726e-157 3.1026106 0.031 0.212 2.470418e-153 CTL_TRT
## Gm33508 9.521258e-156 1.3177717 0.014 0.244 2.856377e-152 CTL_TRT
## Liph 1.094650e-154 2.3969889 0.073 0.173 3.283949e-151 CTL_TRT
## Ak9 4.739120e-154 2.5282804 0.002 0.142 1.421736e-150 CTL_TRT
## Serpinb5 5.579201e-154 2.5290880 0.061 0.226 1.673760e-150 CTL_TRT
## Tnfrsf12a 6.659664e-154 1.7097280 0.084 0.281 1.997899e-150 CTL_TRT
## Hmcn2 3.013768e-153 3.0079910 0.011 0.138 9.041303e-150 CTL_TRT
## Pde1a 5.763315e-153 -0.6446483 0.061 0.140 1.728995e-149 CTL_TRT
## Spag16 7.424424e-153 1.6840685 0.019 0.259 2.227327e-149 CTL_TRT
## Gm9573 1.181635e-152 2.3212538 0.015 0.148 3.544906e-149 CTL_TRT
## Gm13842 3.343500e-152 0.4837475 0.110 0.214 1.003050e-148 CTL_TRT
## Nek5 5.352470e-152 1.4798412 0.008 0.196 1.605741e-148 CTL_TRT
## Prdm14 3.971874e-151 2.8419441 0.073 0.132 1.191562e-147 CTL_TRT
## Ak8 5.872928e-151 2.3973512 0.093 0.215 1.761878e-147 CTL_TRT
## Lrrc39 1.666396e-150 4.0962390 0.068 0.243 4.999188e-147 CTL_TRT
## Cks1brt 1.679412e-148 1.5147445 0.114 0.183 5.038237e-145 CTL_TRT
## Ptgs2 2.145645e-148 1.0767789 0.004 0.141 6.436936e-145 CTL_TRT
## Susd1 2.465144e-148 3.6651762 0.054 0.240 7.395431e-145 CTL_TRT
## Pde6c 8.832081e-148 3.1353960 0.053 0.250 2.649624e-144 CTL_TRT
## Lrp5 9.453864e-148 3.5077502 0.033 0.213 2.836159e-144 CTL_TRT
## Pax6os1 1.407690e-147 2.3218440 0.028 0.198 4.223070e-144 CTL_TRT
## Myb 1.854655e-147 2.8115888 0.019 0.105 5.563966e-144 CTL_TRT
## Gm29394 7.958074e-147 2.0670088 0.007 0.196 2.387422e-143 CTL_TRT
## Vwf 6.220172e-146 3.2804256 0.080 0.186 1.866052e-142 CTL_TRT
## Ccnb1 1.600930e-145 2.3162863 0.019 0.225 4.802791e-142 CTL_TRT
## Gm14064 2.449494e-145 1.1445439 0.009 0.194 7.348481e-142 CTL_TRT
## Tmem44 3.760704e-145 0.9726911 0.005 0.180 1.128211e-141 CTL_TRT
## Lbp 4.020432e-145 1.5079262 0.021 0.180 1.206129e-141 CTL_TRT
## Ptcra 5.172186e-144 2.7419584 0.022 0.225 1.551656e-140 CTL_TRT
## Cacng8 6.462707e-144 2.1247214 0.016 0.196 1.938812e-140 CTL_TRT
## Rbpms 3.721116e-143 2.9841219 0.050 0.222 1.116335e-139 CTL_TRT
## 4930445E18Rik 2.307713e-142 1.8891044 0.018 0.163 6.923139e-139 CTL_TRT
## Hrh4 2.737455e-142 1.6454907 0.122 0.210 8.212364e-139 CTL_TRT
## Mcm5 3.343055e-141 3.9253016 0.091 0.220 1.002917e-137 CTL_TRT
## Tmc2 2.304538e-140 1.7107131 0.007 0.180 6.913614e-137 CTL_TRT
## Gm40264 2.455807e-140 3.3997850 0.003 0.108 7.367420e-137 CTL_TRT
## Trp53cor1 8.400348e-140 2.0252170 0.026 0.303 2.520104e-136 CTL_TRT
## Gm21188 1.815557e-139 1.1884098 0.007 0.315 5.446672e-136 CTL_TRT
## Gm49974 2.105434e-139 2.5448992 0.067 0.111 6.316303e-136 CTL_TRT
## 1700030M09Rik 2.249906e-139 2.3046764 0.084 0.163 6.749717e-136 CTL_TRT
## Fbln1 2.483959e-139 1.4493423 0.009 0.256 7.451878e-136 CTL_TRT
## Styxl1 4.583739e-139 4.1176885 0.056 0.236 1.375122e-135 CTL_TRT
## Rbl1 4.813256e-139 -0.8344704 0.010 0.351 1.443977e-135 CTL_TRT
## Dnah2 6.787220e-139 1.8958333 0.016 0.269 2.036166e-135 CTL_TRT
## Spc25 3.562656e-138 1.9651939 0.006 0.274 1.068797e-134 CTL_TRT
## Gm5095 3.951134e-138 2.8655709 0.027 0.110 1.185340e-134 CTL_TRT
## Apold1 1.255723e-136 -0.2983474 0.027 0.166 3.767169e-133 CTL_TRT
## Myzap 2.388798e-136 2.9567886 0.014 0.162 7.166393e-133 CTL_TRT
## Mrap 3.141346e-136 3.0074226 0.057 0.204 9.424039e-133 CTL_TRT
## 1700064J06Rik 3.608086e-135 2.5720990 0.016 0.113 1.082426e-131 CTL_TRT
## Alox8 5.932583e-135 2.2284658 0.092 0.182 1.779775e-131 CTL_TRT
## Crb1 2.784811e-134 4.2929381 0.014 0.164 8.354432e-131 CTL_TRT
## Wdsub1 1.033533e-133 8.0279574 0.121 0.256 3.100598e-130 CTL_TRT
## Ttc41 7.394977e-133 1.0355573 0.007 0.244 2.218493e-129 CTL_TRT
## Camp 1.390588e-132 0.7570116 0.009 0.195 4.171765e-129 CTL_TRT
## Gm16271 1.494079e-132 2.1535695 0.003 0.169 4.482237e-129 CTL_TRT
## Hba-a2 2.235725e-132 0.2532436 0.074 0.194 6.707174e-129 CTL_TRT
## Gm44284 7.511477e-132 3.2201099 0.022 0.117 2.253443e-128 CTL_TRT
## Ccnf 2.405163e-131 1.7784266 0.026 0.173 7.215489e-128 CTL_TRT
## Wdcp 4.351565e-131 3.8019455 0.193 0.205 1.305470e-127 CTL_TRT
## Maats1 9.117553e-131 2.6603712 0.015 0.209 2.735266e-127 CTL_TRT
## Dennd2c 2.257385e-129 2.5497547 0.057 0.193 6.772154e-126 CTL_TRT
## Gm1110 3.837980e-129 2.1635246 0.151 0.218 1.151394e-125 CTL_TRT
## Olfm3 5.536460e-129 2.6143310 0.033 0.149 1.660938e-125 CTL_TRT
## 4430402I18Rik 6.726496e-129 2.4790074 0.017 0.262 2.017949e-125 CTL_TRT
## Gm42997 7.245080e-129 0.4181819 0.015 0.167 2.173524e-125 CTL_TRT
## Cnga3 8.173429e-129 3.5680750 0.003 0.106 2.452029e-125 CTL_TRT
## Dlk2 1.047434e-128 3.3301556 0.011 0.140 3.142303e-125 CTL_TRT
## Ddx43 2.195800e-128 2.3619477 0.104 0.138 6.587400e-125 CTL_TRT
## Fbxo47 2.718848e-128 2.7673441 0.015 0.316 8.156545e-125 CTL_TRT
## Gm16189 2.952535e-128 2.6841074 0.034 0.261 8.857604e-125 CTL_TRT
## Efcab5 4.707174e-128 0.5185209 0.010 0.220 1.412152e-124 CTL_TRT
## Hsd17b14 1.181787e-127 3.5842734 0.161 0.158 3.545361e-124 CTL_TRT
## Grxcr2 1.236059e-127 0.9063355 0.018 0.203 3.708176e-124 CTL_TRT
## Gm31045 2.847140e-127 2.0659715 0.004 0.113 8.541420e-124 CTL_TRT
## Cc2d2b 3.066399e-127 3.3191378 0.030 0.148 9.199198e-124 CTL_TRT
## Gm35460 9.716926e-127 2.2433540 0.031 0.233 2.915078e-123 CTL_TRT
## Tnfrsf26 1.597182e-126 2.7477745 0.064 0.134 4.791547e-123 CTL_TRT
## Gm15489 1.927087e-126 4.3315066 0.063 0.140 5.781260e-123 CTL_TRT
## Eya4 1.642939e-125 1.6691567 0.011 0.133 4.928817e-122 CTL_TRT
## Fzd4 6.041391e-125 0.8467832 0.015 0.145 1.812417e-121 CTL_TRT
## Gm13853 9.449620e-125 2.6689229 0.184 0.287 2.834886e-121 CTL_TRT
## 9130230L23Rik 1.549684e-124 1.8683362 0.034 0.260 4.649051e-121 CTL_TRT
## Snx20 3.025012e-124 1.5251748 0.003 0.118 9.075036e-121 CTL_TRT
## Gm5134 3.572561e-124 3.0122131 0.031 0.128 1.071768e-120 CTL_TRT
## Itga1 2.739301e-123 1.6316522 0.066 0.164 8.217902e-120 CTL_TRT
## Trmt61b 2.805594e-123 3.3626369 0.163 0.211 8.416783e-120 CTL_TRT
## 1700017N19Rik 5.958307e-123 3.4797945 0.054 0.142 1.787492e-119 CTL_TRT
## 4930473D10Rik 2.046983e-122 2.8106643 0.052 0.172 6.140950e-119 CTL_TRT
## Pgm5 2.512661e-122 0.6756507 0.017 0.214 7.537983e-119 CTL_TRT
## Tmem132d 1.452211e-120 2.3985998 0.039 0.156 4.356632e-117 CTL_TRT
## Gm16023 6.082429e-120 1.8270630 0.020 0.228 1.824729e-116 CTL_TRT
## Gemin5 9.448726e-120 4.3342166 0.072 0.209 2.834618e-116 CTL_TRT
## Pik3ap1 9.585102e-120 3.4056578 0.005 0.104 2.875531e-116 CTL_TRT
## Trpm5 1.121271e-119 3.1463263 0.003 0.232 3.363812e-116 CTL_TRT
## Lrrc32 3.319250e-119 3.8145447 0.006 0.147 9.957750e-116 CTL_TRT
## Slc12a7 3.506177e-119 5.1397042 0.058 0.207 1.051853e-115 CTL_TRT
## Matk 7.007615e-119 3.9887428 0.048 0.204 2.102285e-115 CTL_TRT
## Ube2c 1.467356e-118 3.0078210 0.005 0.234 4.402068e-115 CTL_TRT
## Cdkn2a 1.512102e-118 0.8489963 0.005 0.212 4.536307e-115 CTL_TRT
## Adam2 1.530894e-118 3.5390763 0.153 0.214 4.592681e-115 CTL_TRT
## Rftn2 5.560816e-118 2.7698277 0.034 0.156 1.668245e-114 CTL_TRT
## E230025N22Rik 3.466774e-117 2.5358086 0.161 0.201 1.040032e-113 CTL_TRT
## Ddb2 1.997335e-116 4.0918477 0.094 0.194 5.992006e-113 CTL_TRT
## Brinp3 2.668424e-116 1.2145576 0.038 0.101 8.005272e-113 CTL_TRT
## Gm26854 1.524073e-114 5.5560205 0.002 0.200 4.572218e-111 CTL_TRT
## Nr6a1os 2.785843e-114 3.0664837 0.019 0.113 8.357530e-111 CTL_TRT
## BC035044 3.273904e-114 1.2731799 0.003 0.148 9.821711e-111 CTL_TRT
## 5330439M10Rik 3.498273e-114 2.0207146 0.003 0.222 1.049482e-110 CTL_TRT
## Cabp7 5.877335e-114 2.2782724 0.029 0.193 1.763200e-110 CTL_TRT
## Cgas 2.343115e-113 4.4505990 0.069 0.245 7.029346e-110 CTL_TRT
## Dsg2 2.524460e-113 2.9310716 0.042 0.189 7.573379e-110 CTL_TRT
## Vamp9 7.463108e-113 2.5555809 0.047 0.215 2.238932e-109 CTL_TRT
## Thbs4 4.395748e-112 4.1353985 0.006 0.260 1.318724e-108 CTL_TRT
## Cavin1 7.991710e-112 -1.6804212 0.090 0.257 2.397513e-108 CTL_TRT
## Slc22a20 1.239207e-111 2.3885004 0.043 0.110 3.717622e-108 CTL_TRT
## Myo5b 2.268199e-111 1.9133988 0.004 0.143 6.804596e-108 CTL_TRT
## Rec114 3.795442e-111 2.7212438 0.052 0.159 1.138633e-107 CTL_TRT
## Eya2 8.446793e-111 3.2517408 0.025 0.216 2.534038e-107 CTL_TRT
## Tshr 1.909972e-110 2.6510374 0.020 0.169 5.729916e-107 CTL_TRT
## Tmeff1 2.064531e-110 3.0966247 0.212 0.256 6.193594e-107 CTL_TRT
## B930036N10Rik 2.139373e-109 3.5175264 0.063 0.269 6.418120e-106 CTL_TRT
## Fcrl5 5.162340e-109 1.3026748 0.007 0.238 1.548702e-105 CTL_TRT
## Gm29773 7.237010e-109 3.0713325 0.188 0.230 2.171103e-105 CTL_TRT
## Gm31458 7.391166e-109 1.1703641 0.016 0.186 2.217350e-105 CTL_TRT
## Rad51 9.746081e-109 3.9783829 0.027 0.213 2.923824e-105 CTL_TRT
## Fgg 1.068272e-108 0.9470301 0.106 0.198 3.204815e-105 CTL_TRT
## Vcan 1.745076e-108 0.4274264 0.034 0.190 5.235228e-105 CTL_TRT
## Procr 5.256854e-108 3.4103808 0.006 0.163 1.577056e-104 CTL_TRT
## Svopl 5.846536e-108 2.0909171 0.007 0.122 1.753961e-104 CTL_TRT
## 4933423P22Rik 3.660829e-107 1.7557209 0.009 0.133 1.098249e-103 CTL_TRT
## Gm46224 3.994268e-107 1.8752962 0.003 0.152 1.198280e-103 CTL_TRT
## Calcrl 6.713095e-107 3.6333085 0.047 0.176 2.013928e-103 CTL_TRT
## Col4a3 1.413777e-106 0.4307444 0.010 0.152 4.241330e-103 CTL_TRT
## Hydin 1.785436e-106 1.5570194 0.011 0.171 5.356308e-103 CTL_TRT
## Sp7 4.978195e-106 2.1882839 0.038 0.169 1.493459e-102 CTL_TRT
## Tnfrsf1b 7.871106e-106 0.3799194 0.012 0.183 2.361332e-102 CTL_TRT
## Mybl1 1.238832e-105 4.4452855 0.026 0.264 3.716496e-102 CTL_TRT
## Slfn5 2.158940e-105 1.4821456 0.021 0.197 6.476821e-102 CTL_TRT
## A330084C13Rik 2.332750e-105 8.3111095 0.056 0.226 6.998249e-102 CTL_TRT
## Chrna9 3.809057e-105 2.4576355 0.005 0.195 1.142717e-101 CTL_TRT
## Alox5ap 4.325803e-105 -0.6945771 0.014 0.182 1.297741e-101 CTL_TRT
## Mrgpra3 4.432623e-105 3.5585697 0.074 0.216 1.329787e-101 CTL_TRT
## Wdfy4 2.549255e-104 1.4990073 0.007 0.166 7.647765e-101 CTL_TRT
## Dlgap2 4.457290e-104 3.8204207 0.050 0.174 1.337187e-100 CTL_TRT
## Gm15286 6.064179e-104 2.0186767 0.008 0.206 1.819254e-100 CTL_TRT
## Exd2 7.811314e-104 2.4432983 0.149 0.185 2.343394e-100 CTL_TRT
## Gm10069 9.426350e-104 3.1480225 0.087 0.193 2.827905e-100 CTL_TRT
## Svep1 2.274423e-103 3.5662860 0.007 0.107 6.823268e-100 CTL_TRT
## Olfr889 6.866107e-103 1.7106721 0.173 0.165 2.059832e-99 CTL_TRT
## 5830444B04Rik 7.426450e-103 2.3608458 0.014 0.203 2.227935e-99 CTL_TRT
## Gm49953 1.243348e-102 2.9939643 0.116 0.172 3.730043e-99 CTL_TRT
## Gm34455 2.085813e-102 3.9327500 0.065 0.215 6.257440e-99 CTL_TRT
## Aldh1a3 3.586677e-102 3.1541454 0.182 0.218 1.076003e-98 CTL_TRT
## Gm32916 8.638571e-102 4.2351278 0.044 0.239 2.591571e-98 CTL_TRT
## Scrg1 1.191088e-101 3.5276442 0.003 0.171 3.573264e-98 CTL_TRT
## Prr11 1.847522e-101 1.4551642 0.015 0.195 5.542567e-98 CTL_TRT
## 9130204L05Rik 3.255631e-101 1.8018649 0.143 0.228 9.766892e-98 CTL_TRT
## Cblc 1.294614e-100 3.6275142 0.165 0.201 3.883841e-97 CTL_TRT
## Casp8 2.314798e-100 2.8931665 0.014 0.213 6.944394e-97 CTL_TRT
## Gm45669 2.979136e-100 2.4832081 0.014 0.206 8.937407e-97 CTL_TRT
## Gm10457 8.354524e-100 2.3634338 0.108 0.186 2.506357e-96 CTL_TRT
## Pglyrp1 1.165075e-98 0.4361499 0.016 0.180 3.495225e-95 CTL_TRT
## Slc22a4 1.310338e-98 4.5072785 0.039 0.240 3.931014e-95 CTL_TRT
## Ak7 1.372401e-98 3.3321472 0.052 0.192 4.117203e-95 CTL_TRT
## BC049352 1.450229e-98 0.7550177 0.010 0.223 4.350687e-95 CTL_TRT
## Lgals3 2.311531e-98 -0.9973393 0.114 0.246 6.934593e-95 CTL_TRT
## Cntnap5b 5.138137e-98 2.3109201 0.098 0.154 1.541441e-94 CTL_TRT
## Gm13427 2.038948e-97 2.1955686 0.052 0.104 6.116845e-94 CTL_TRT
## Btk 2.452819e-97 2.9095981 0.115 0.208 7.358458e-94 CTL_TRT
## Dnah10 2.467730e-97 3.5165498 0.045 0.214 7.403190e-94 CTL_TRT
## Pthlh 3.461188e-97 1.8338807 0.023 0.275 1.038356e-93 CTL_TRT
## Enpp6 4.033826e-97 1.9111630 0.017 0.132 1.210148e-93 CTL_TRT
## Gm3417 2.258713e-96 1.6987505 0.014 0.176 6.776138e-93 CTL_TRT
## Endov 5.127621e-96 3.2039764 0.077 0.232 1.538286e-92 CTL_TRT
## 4930471E19Rik 3.473836e-95 2.7545945 0.112 0.198 1.042151e-91 CTL_TRT
## Xylt1 1.777974e-94 2.3337107 0.026 0.135 5.333922e-91 CTL_TRT
## Gm16168 2.160035e-94 3.6173418 0.013 0.146 6.480104e-91 CTL_TRT
## Gm40518 6.276280e-94 2.1411639 0.066 0.239 1.882884e-90 CTL_TRT
## Gm11961 2.051560e-93 1.7785740 0.036 0.230 6.154680e-90 CTL_TRT
## Stard8 3.027898e-93 3.6924916 0.033 0.145 9.083693e-90 CTL_TRT
## Nrros 5.432988e-93 2.4271338 0.011 0.200 1.629896e-89 CTL_TRT
## 1810006J02Rik 5.599595e-93 1.5657033 0.006 0.138 1.679878e-89 CTL_TRT
## Gm26549 2.431223e-92 5.6625825 0.026 0.261 7.293668e-89 CTL_TRT
## Sox6os 7.135230e-92 2.3995928 0.005 0.269 2.140569e-88 CTL_TRT
## Gm12514 7.170723e-92 2.9607723 0.003 0.134 2.151217e-88 CTL_TRT
## Gm45509 7.289294e-92 3.5412157 0.028 0.269 2.186788e-88 CTL_TRT
## Ifi44 8.279255e-92 -0.4233231 0.009 0.204 2.483776e-88 CTL_TRT
## Angpt2 1.087522e-91 8.1207128 0.052 0.129 3.262567e-88 CTL_TRT
## Atxn7l1os1 1.644924e-91 2.9018712 0.139 0.209 4.934773e-88 CTL_TRT
## 9130410C08Rik 1.261225e-90 1.3467136 0.051 0.139 3.783674e-87 CTL_TRT
## Apol7e 1.272330e-90 1.9021027 0.053 0.104 3.816991e-87 CTL_TRT
## Gm36539 1.491389e-90 2.6225283 0.016 0.124 4.474167e-87 CTL_TRT
## Megf6 3.383732e-90 2.2707965 0.024 0.186 1.015120e-86 CTL_TRT
## Slc8b1 9.392301e-90 7.5173218 0.055 0.262 2.817690e-86 CTL_TRT
## Cdh13 1.972235e-89 2.3869992 0.075 0.174 5.916704e-86 CTL_TRT
## Mgp 2.416664e-89 0.6185107 0.031 0.147 7.249993e-86 CTL_TRT
## Myo1h 6.362421e-89 3.1291802 0.137 0.231 1.908726e-85 CTL_TRT
## Rasgrp2 9.550997e-89 3.5392321 0.097 0.251 2.865299e-85 CTL_TRT
## Thbs1 1.144465e-88 0.4926613 0.018 0.197 3.433394e-85 CTL_TRT
## Gm42439 1.182602e-88 2.6571756 0.043 0.108 3.547807e-85 CTL_TRT
## Tll1 2.439600e-88 1.7550048 0.034 0.138 7.318800e-85 CTL_TRT
## Cryzl2 3.050699e-88 1.7585414 0.026 0.245 9.152098e-85 CTL_TRT
## Aoah 3.923315e-88 3.0061339 0.012 0.156 1.176994e-84 CTL_TRT
## Lmo7 1.570393e-87 -0.5283987 0.101 0.161 4.711179e-84 CTL_TRT
## Gucy1b1 3.441588e-87 3.9433838 0.008 0.108 1.032476e-83 CTL_TRT
## St8sia2 3.541338e-87 2.7132134 0.012 0.254 1.062402e-83 CTL_TRT
## Lhfpl1 4.191029e-87 -0.4409989 0.061 0.186 1.257309e-83 CTL_TRT
## Wdr76 5.214550e-87 5.0989493 0.026 0.243 1.564365e-83 CTL_TRT
## Wfdc17 6.532475e-87 1.1577829 0.033 0.206 1.959743e-83 CTL_TRT
## Cep95 1.210952e-86 5.2401085 0.096 0.213 3.632855e-83 CTL_TRT
## Acss3 1.485670e-86 2.7128551 0.023 0.124 4.457011e-83 CTL_TRT
## 4930419G24Rik 6.150997e-86 5.8357215 0.006 0.128 1.845299e-82 CTL_TRT
## Loxl1 4.683116e-85 1.7410345 0.039 0.232 1.404935e-81 CTL_TRT
## Alox12 5.120654e-85 1.7885108 0.004 0.158 1.536196e-81 CTL_TRT
## Myo3b 1.545841e-83 3.9807683 0.065 0.184 4.637523e-80 CTL_TRT
## Hcst 2.126370e-83 0.6177809 0.004 0.196 6.379109e-80 CTL_TRT
## Hba-a1 2.184340e-83 0.3789981 0.086 0.216 6.553020e-80 CTL_TRT
## BC025920 3.167330e-83 4.5392935 0.076 0.117 9.501989e-80 CTL_TRT
## Stk10 8.445370e-83 4.6032890 0.041 0.149 2.533611e-79 CTL_TRT
## Ino80dos 1.795698e-82 4.6811383 0.073 0.261 5.387093e-79 CTL_TRT
## 4931414P19Rik 1.954206e-82 4.0739193 0.037 0.232 5.862617e-79 CTL_TRT
## Fam151a 3.445366e-82 2.9682061 0.011 0.136 1.033610e-78 CTL_TRT
## C1qtnf7 7.819119e-82 1.5854655 0.064 0.147 2.345736e-78 CTL_TRT
## Tmem252 9.614325e-82 1.4550526 0.002 0.153 2.884297e-78 CTL_TRT
## Cpxm1 9.819041e-82 -5.4591703 0.031 0.288 2.945712e-78 CTL_TRT
## Kif14 1.187944e-81 2.7337251 0.037 0.137 3.563833e-78 CTL_TRT
## Gm42109 1.221616e-81 4.1922677 0.046 0.128 3.664847e-78 CTL_TRT
## Cldn5 1.641125e-81 3.5819463 0.026 0.152 4.923376e-78 CTL_TRT
## Mymk 1.892981e-81 3.1300913 0.009 0.102 5.678942e-78 CTL_TRT
## Unc45b 2.063862e-81 0.5027444 0.005 0.133 6.191586e-78 CTL_TRT
## Folr2 2.528726e-81 2.4591326 0.003 0.166 7.586179e-78 CTL_TRT
## Gm16272 2.878318e-81 4.4260387 0.066 0.123 8.634955e-78 CTL_TRT
## 6030443J06Rik 3.309894e-81 2.0062096 0.149 0.192 9.929683e-78 CTL_TRT
## Gm37571 8.969187e-81 2.8094137 0.050 0.165 2.690756e-77 CTL_TRT
## F11r 9.352121e-81 1.2939825 0.043 0.241 2.805636e-77 CTL_TRT
## Cdc6 1.209074e-80 1.9858713 0.003 0.186 3.627222e-77 CTL_TRT
## Alpk1 1.327840e-80 2.4917565 0.049 0.161 3.983521e-77 CTL_TRT
## Zfp13 1.378608e-80 2.1118694 0.160 0.165 4.135823e-77 CTL_TRT
## Herc6 1.669932e-80 2.5345722 0.052 0.143 5.009797e-77 CTL_TRT
## Medag 4.398130e-80 1.4962548 0.013 0.185 1.319439e-76 CTL_TRT
## Gm40538 6.970377e-80 1.6244372 0.074 0.135 2.091113e-76 CTL_TRT
## Glra1 1.085469e-79 1.2103839 0.118 0.226 3.256408e-76 CTL_TRT
## Phkg1 1.801181e-79 3.0907980 0.039 0.209 5.403544e-76 CTL_TRT
## Tsga10ip 4.483840e-79 2.4629011 0.039 0.150 1.345152e-75 CTL_TRT
## Ppp2r5a 4.784417e-79 6.9282927 0.114 0.215 1.435325e-75 CTL_TRT
## Prtg 5.181175e-79 3.2511590 0.175 0.184 1.554352e-75 CTL_TRT
## Zbtb8a 7.051605e-79 1.8500605 0.052 0.195 2.115481e-75 CTL_TRT
## Scara5 7.237801e-79 1.2104088 0.008 0.132 2.171340e-75 CTL_TRT
## Plin1 1.104394e-78 4.0299766 0.008 0.168 3.313182e-75 CTL_TRT
## Hgf 1.314509e-78 2.1329657 0.097 0.176 3.943528e-75 CTL_TRT
## Nck2 1.732307e-78 4.6607261 0.051 0.197 5.196920e-75 CTL_TRT
## Cartpt 1.775725e-78 2.2618280 0.185 0.173 5.327175e-75 CTL_TRT
## Cacnb2 1.995507e-78 0.9773200 0.093 0.160 5.986521e-75 CTL_TRT
## Wdr12 2.334130e-78 1.8863479 0.217 0.233 7.002389e-75 CTL_TRT
## F830016B08Rik 2.709367e-78 1.1577063 0.003 0.108 8.128101e-75 CTL_TRT
## Npl 3.310468e-78 4.3035886 0.055 0.213 9.931405e-75 CTL_TRT
## Flt4 5.644673e-78 3.1803783 0.030 0.177 1.693402e-74 CTL_TRT
## Actn2 6.416355e-78 0.7293876 0.045 0.170 1.924907e-74 CTL_TRT
## Ankrd35 6.513825e-78 5.2410258 0.068 0.239 1.954147e-74 CTL_TRT
## Jam3 8.004353e-78 5.6647838 0.172 0.225 2.401306e-74 CTL_TRT
## Gal 1.047923e-77 -0.4555568 0.216 0.243 3.143770e-74 CTL_TRT
## Trabd2b 1.135437e-77 0.4557783 0.016 0.154 3.406310e-74 CTL_TRT
## Lockd 1.744666e-77 2.7235383 0.010 0.216 5.233997e-74 CTL_TRT
## Prokr2 2.021239e-77 1.6412575 0.044 0.217 6.063718e-74 CTL_TRT
## Spag1 2.485545e-77 4.1411573 0.025 0.237 7.456636e-74 CTL_TRT
## Trhde 2.653080e-77 2.3566550 0.075 0.146 7.959241e-74 CTL_TRT
## Oplah 5.148971e-77 3.5848030 0.121 0.183 1.544691e-73 CTL_TRT
## Mrgprd 5.337108e-77 -3.0236523 0.100 0.131 1.601132e-73 CTL_TRT
## Dock1 6.284657e-77 2.7269023 0.092 0.183 1.885397e-73 CTL_TRT
## Col7a1 1.313508e-76 2.4949179 0.027 0.142 3.940523e-73 CTL_TRT
## Cdkl4 1.622868e-76 3.0153894 0.011 0.233 4.868604e-73 CTL_TRT
## E330021D16Rik 1.648554e-76 2.9153489 0.056 0.117 4.945662e-73 CTL_TRT
## C730034F03Rik 2.085928e-76 2.5966723 0.047 0.234 6.257785e-73 CTL_TRT
## 2810403D21Rik 4.695824e-76 3.1859243 0.209 0.243 1.408747e-72 CTL_TRT
## Smpd3 1.117141e-75 0.5171952 0.163 0.267 3.351424e-72 CTL_TRT
## Abcb10 2.620822e-75 2.7675293 0.123 0.207 7.862467e-72 CTL_TRT
## Pi16 2.971734e-75 2.6462735 0.020 0.166 8.915201e-72 CTL_TRT
## Kcnq4 3.229196e-75 2.9336652 0.084 0.138 9.687587e-72 CTL_TRT
## Gm20274 3.582375e-75 2.4618676 0.038 0.205 1.074713e-71 CTL_TRT
## Gm47077 3.961409e-75 3.6350758 0.021 0.145 1.188423e-71 CTL_TRT
## Grk4 4.915023e-75 2.5115702 0.061 0.221 1.474507e-71 CTL_TRT
## Gm567 5.350727e-75 1.9706437 0.082 0.170 1.605218e-71 CTL_TRT
## Nme5 7.915918e-75 4.5276896 0.082 0.191 2.374775e-71 CTL_TRT
## Mef2c 1.610915e-74 -0.8121776 0.240 0.263 4.832746e-71 CTL_TRT
## Pdgfra 1.910302e-74 -0.3860521 0.017 0.162 5.730907e-71 CTL_TRT
## Gm15862 2.404724e-74 2.6954477 0.082 0.208 7.214173e-71 CTL_TRT
## Angptl1 2.715841e-74 -0.2713637 0.016 0.166 8.147523e-71 CTL_TRT
## Dnah12 3.030506e-74 2.8732333 0.021 0.128 9.091518e-71 CTL_TRT
## Aunip 3.085871e-74 2.9590219 0.027 0.227 9.257614e-71 CTL_TRT
## 1700109K24Rik 4.978032e-74 5.5964987 0.005 0.118 1.493409e-70 CTL_TRT
## Ccn3 8.845236e-74 1.2709026 0.046 0.212 2.653571e-70 CTL_TRT
## Csf2rb 1.271333e-73 3.8682147 0.009 0.121 3.813998e-70 CTL_TRT
## 1700054A03Rik 1.327641e-73 1.7866146 0.003 0.142 3.982922e-70 CTL_TRT
## Nexmif 1.475922e-73 3.6969030 0.045 0.183 4.427767e-70 CTL_TRT
## Unc5d 1.567516e-73 2.2718939 0.088 0.150 4.702547e-70 CTL_TRT
## Ptgis 2.339891e-73 3.3055318 0.031 0.108 7.019674e-70 CTL_TRT
## Cpne5 2.696631e-73 6.6468172 0.040 0.138 8.089893e-70 CTL_TRT
## Dab2 3.077684e-73 3.4109514 0.031 0.153 9.233053e-70 CTL_TRT
## Gm41555 3.534296e-73 2.3248544 0.034 0.159 1.060289e-69 CTL_TRT
## Gm50013 6.642367e-73 2.3906211 0.033 0.214 1.992710e-69 CTL_TRT
## Gm12002 7.081697e-73 0.8899961 0.022 0.155 2.124509e-69 CTL_TRT
## Syk 7.765076e-73 1.1565603 0.007 0.107 2.329523e-69 CTL_TRT
## Dgkb 1.237873e-72 1.4864323 0.092 0.172 3.713618e-69 CTL_TRT
## Klhl41 1.475975e-72 0.5440295 0.025 0.192 4.427926e-69 CTL_TRT
## Vps37b 2.308639e-72 -1.7676075 0.078 0.227 6.925916e-69 CTL_TRT
## Smr2 3.652579e-72 2.3206455 0.032 0.279 1.095774e-68 CTL_TRT
## Ezh2 8.474310e-72 7.9688829 0.211 0.241 2.542293e-68 CTL_TRT
## Scd3 1.013590e-71 2.4406809 0.004 0.130 3.040769e-68 CTL_TRT
## Flrt2 1.537932e-71 0.5386987 0.114 0.181 4.613795e-68 CTL_TRT
## Cfap61 2.450324e-71 3.0068029 0.108 0.195 7.350971e-68 CTL_TRT
## Rep15 8.962993e-71 4.2359992 0.040 0.209 2.688898e-67 CTL_TRT
## A330069K06Rik 2.297090e-69 0.3621266 0.014 0.136 6.891270e-66 CTL_TRT
## Gm32509 4.589087e-69 3.0006375 0.068 0.119 1.376726e-65 CTL_TRT
## Itga6 5.216908e-69 -1.7852485 0.205 0.243 1.565072e-65 CTL_TRT
## Atxn7 5.327632e-69 6.0169076 0.180 0.236 1.598290e-65 CTL_TRT
## Fjx1 7.720510e-69 1.8363396 0.027 0.133 2.316153e-65 CTL_TRT
## Gm34084 1.118557e-68 1.5068861 0.002 0.121 3.355670e-65 CTL_TRT
## Mical1 1.375982e-68 4.7799848 0.213 0.242 4.127945e-65 CTL_TRT
## C130073E24Rik 1.291692e-67 1.9870562 0.077 0.119 3.875075e-64 CTL_TRT
## Gm48249 1.785141e-67 2.8876791 0.101 0.206 5.355422e-64 CTL_TRT
## Gm15879 2.415967e-67 5.4215786 0.025 0.194 7.247902e-64 CTL_TRT
## Tjp2 3.001356e-67 2.8902308 0.068 0.212 9.004067e-64 CTL_TRT
## Bgn 4.823110e-67 0.4090124 0.086 0.255 1.446933e-63 CTL_TRT
## Gm26586 5.187795e-67 1.9708171 0.080 0.164 1.556338e-63 CTL_TRT
## Muc13 8.673365e-67 2.8669943 0.003 0.187 2.602010e-63 CTL_TRT
## Il21r 1.538076e-66 1.3970801 0.001 0.102 4.614227e-63 CTL_TRT
## Resp18 1.650263e-66 1.7289223 0.303 0.246 4.950789e-63 CTL_TRT
## B230216N24Rik 1.958243e-66 3.3544754 0.105 0.115 5.874729e-63 CTL_TRT
## Tcf7l1 4.202404e-66 4.8293984 0.072 0.159 1.260721e-62 CTL_TRT
## Notch3 7.353259e-66 1.5326259 0.020 0.122 2.205978e-62 CTL_TRT
## Shoc1 1.080260e-65 4.9230169 0.111 0.169 3.240780e-62 CTL_TRT
## Gm525 1.264352e-65 1.8043133 0.120 0.149 3.793057e-62 CTL_TRT
## Chrna3 1.479588e-65 1.5709006 0.030 0.160 4.438765e-62 CTL_TRT
## Gm9725 3.329637e-65 2.2621497 0.005 0.122 9.988912e-62 CTL_TRT
## Galntl6 6.219597e-65 3.0615877 0.079 0.100 1.865879e-61 CTL_TRT
## Sptbn5 1.651353e-64 2.2579486 0.025 0.207 4.954059e-61 CTL_TRT
## Cfap43 2.285627e-64 3.9926417 0.034 0.151 6.856881e-61 CTL_TRT
## Pdlim2 2.447884e-64 3.1191355 0.169 0.178 7.343652e-61 CTL_TRT
## Crispld2 6.307937e-64 2.1677529 0.013 0.122 1.892381e-60 CTL_TRT
## Crabp2 6.972275e-64 0.4433757 0.025 0.221 2.091683e-60 CTL_TRT
## Gm10754 1.057455e-63 3.1832210 0.059 0.128 3.172365e-60 CTL_TRT
## Mpl 1.983071e-63 3.7211097 0.004 0.113 5.949214e-60 CTL_TRT
## Evc2 2.070668e-63 1.2447159 0.021 0.242 6.212005e-60 CTL_TRT
## She 3.365145e-63 0.6869928 0.009 0.178 1.009543e-59 CTL_TRT
## Pzp 5.572658e-63 4.3667456 0.194 0.162 1.671798e-59 CTL_TRT
## Ephb3 6.413631e-63 3.2736046 0.021 0.251 1.924089e-59 CTL_TRT
## Sntg1 6.889223e-63 0.7832541 0.142 0.135 2.066767e-59 CTL_TRT
## B830012L14Rik 9.440936e-63 0.3348671 0.195 0.183 2.832281e-59 CTL_TRT
## Spata31d1a 9.895276e-63 2.3809156 0.041 0.111 2.968583e-59 CTL_TRT
## Gm30489 1.152640e-62 -1.2497578 0.098 0.177 3.457920e-59 CTL_TRT
## Trim7 1.227952e-62 2.8339088 0.028 0.206 3.683855e-59 CTL_TRT
## Gng8 1.802340e-62 2.8330673 0.106 0.165 5.407021e-59 CTL_TRT
## Gm32885 1.949426e-62 1.4305541 0.005 0.192 5.848278e-59 CTL_TRT
## Aebp1 2.170358e-62 2.2613662 0.012 0.179 6.511074e-59 CTL_TRT
## Nxn 1.100846e-61 -2.6862469 0.229 0.238 3.302539e-58 CTL_TRT
## Zfp444 1.180490e-61 5.0325492 0.159 0.210 3.541471e-58 CTL_TRT
## Col8a1 1.487516e-61 1.3609179 0.070 0.143 4.462548e-58 CTL_TRT
## Sox13 1.783849e-61 3.3073321 0.024 0.244 5.351547e-58 CTL_TRT
## Islr 2.193530e-61 0.3589246 0.015 0.121 6.580590e-58 CTL_TRT
## Ly6h 4.551663e-61 3.6060643 0.229 0.184 1.365499e-57 CTL_TRT
## Pmp2 5.876244e-61 0.5340567 0.014 0.234 1.762873e-57 CTL_TRT
## Grm5 7.875202e-61 2.0185553 0.056 0.147 2.362561e-57 CTL_TRT
## Pou6f2 8.476486e-61 2.0270463 0.063 0.110 2.542946e-57 CTL_TRT
## Ttn 1.428378e-60 2.4494535 0.012 0.220 4.285134e-57 CTL_TRT
## Lipg 2.461024e-60 1.9028570 0.025 0.138 7.383071e-57 CTL_TRT
## 1700120C14Rik 2.728338e-60 1.8624438 0.062 0.194 8.185015e-57 CTL_TRT
## Nhlh2 4.407334e-60 2.5102584 0.022 0.112 1.322200e-56 CTL_TRT
## Rapgef5 5.554043e-60 1.5766867 0.209 0.263 1.666213e-56 CTL_TRT
## Anxa1 6.204724e-60 1.3402891 0.008 0.120 1.861417e-56 CTL_TRT
## Lum 1.605349e-59 -1.8807373 0.054 0.169 4.816047e-56 CTL_TRT
## 9230105E05Rik 1.934773e-59 3.7901036 0.055 0.171 5.804320e-56 CTL_TRT
## Cyp26b1 2.060754e-59 1.6272821 0.009 0.131 6.182261e-56 CTL_TRT
## Dhdh 2.241344e-59 3.0593539 0.081 0.254 6.724031e-56 CTL_TRT
## Gm28198 3.341396e-59 2.9077801 0.170 0.229 1.002419e-55 CTL_TRT
## H2-DMb1 4.802184e-59 2.4348175 0.009 0.103 1.440655e-55 CTL_TRT
## Ltbp1 5.149250e-59 1.1871906 0.033 0.148 1.544775e-55 CTL_TRT
## Il1rap 5.200979e-59 2.0255383 0.069 0.159 1.560294e-55 CTL_TRT
## Ifi27l2a 8.480593e-59 2.0837771 0.206 0.214 2.544178e-55 CTL_TRT
## Grasp 9.063553e-59 -3.7052540 0.019 0.288 2.719066e-55 CTL_TRT
## Rbbp8 1.134034e-58 4.9157744 0.063 0.208 3.402102e-55 CTL_TRT
## 4921518K17Rik 1.259069e-58 2.9201215 0.052 0.203 3.777207e-55 CTL_TRT
## Slc23a3 1.661354e-58 1.7426275 0.002 0.105 4.984063e-55 CTL_TRT
## Rtl4 2.214611e-58 2.8299987 0.061 0.100 6.643833e-55 CTL_TRT
## Sult1a1 2.308748e-58 1.2314653 0.036 0.263 6.926243e-55 CTL_TRT
## Nme7 2.318000e-58 0.5434625 0.094 0.343 6.954000e-55 CTL_TRT
## Chrna7 2.603571e-58 2.5838551 0.044 0.140 7.810712e-55 CTL_TRT
## Pvalb 4.749071e-58 1.0522955 0.292 0.286 1.424721e-54 CTL_TRT
## AW011738 7.269958e-58 2.6490907 0.024 0.165 2.180987e-54 CTL_TRT
## Cgnl1 7.636144e-58 2.9149334 0.119 0.247 2.290843e-54 CTL_TRT
## Cdh8 9.768813e-58 2.7491950 0.151 0.163 2.930644e-54 CTL_TRT
## Plpp1 1.190877e-57 5.2681046 0.230 0.262 3.572631e-54 CTL_TRT
## Abcg2 1.225308e-57 1.7299455 0.174 0.229 3.675925e-54 CTL_TRT
## Fgf14 1.270124e-57 1.2654743 0.058 0.101 3.810372e-54 CTL_TRT
## Rel 1.514984e-57 1.1302930 0.095 0.200 4.544952e-54 CTL_TRT
## Hspb1 2.600532e-57 5.7779431 0.370 0.451 7.801596e-54 CTL_TRT
## Ebf2 3.246183e-57 1.1576513 0.023 0.184 9.738550e-54 CTL_TRT
## Cxcl16 3.531733e-57 1.5682728 0.010 0.140 1.059520e-53 CTL_TRT
## Cyp4f17 3.552777e-57 1.5863367 0.008 0.224 1.065833e-53 CTL_TRT
## Podxl 3.821043e-57 -0.7099726 0.020 0.213 1.146313e-53 CTL_TRT
## Egflam 3.983507e-57 2.8745799 0.029 0.171 1.195052e-53 CTL_TRT
## L3mbtl4 4.229698e-57 2.3438399 0.099 0.123 1.268909e-53 CTL_TRT
## Bmp4 5.697238e-57 1.8428992 0.127 0.136 1.709171e-53 CTL_TRT
## Gm28750 5.911338e-57 3.8718253 0.002 0.211 1.773401e-53 CTL_TRT
## Gm10863 6.089213e-57 1.2151177 0.023 0.171 1.826764e-53 CTL_TRT
## Cyp2c23 7.864001e-57 0.5493015 0.016 0.130 2.359200e-53 CTL_TRT
## 1700095J07Rik 8.359680e-57 3.2580559 0.023 0.110 2.507904e-53 CTL_TRT
## Rapgef4os1 8.953353e-57 1.2178490 0.072 0.165 2.686006e-53 CTL_TRT
## Ada 1.280579e-56 1.8816889 0.073 0.160 3.841738e-53 CTL_TRT
## Mgat4e 1.891690e-56 2.4821384 0.047 0.232 5.675069e-53 CTL_TRT
## Hipk2 1.953330e-56 2.9349401 0.121 0.239 5.859991e-53 CTL_TRT
## Gm49003 4.071005e-56 1.0557631 0.012 0.109 1.221302e-52 CTL_TRT
## A830035A12Rik 4.946337e-56 3.1332901 0.003 0.147 1.483901e-52 CTL_TRT
## Atpaf2 7.692197e-56 -0.6231778 0.270 0.246 2.307659e-52 CTL_TRT
## Ror2 2.863740e-55 6.5910322 0.199 0.198 8.591221e-52 CTL_TRT
## Slc4a10 6.822777e-55 2.4434412 0.074 0.111 2.046833e-51 CTL_TRT
## Nppb 7.592525e-55 -3.8787884 0.119 0.134 2.277758e-51 CTL_TRT
## Fam47e 1.067639e-54 2.3443039 0.094 0.172 3.202916e-51 CTL_TRT
## Rgs16 1.540048e-54 -0.9891796 0.037 0.184 4.620145e-51 CTL_TRT
## Ccer2 1.594569e-54 1.5009805 0.008 0.148 4.783707e-51 CTL_TRT
## Cadps2 1.737188e-54 3.1795259 0.109 0.170 5.211565e-51 CTL_TRT
## Wnt5b 3.585488e-54 3.5098344 0.026 0.192 1.075646e-50 CTL_TRT
## Cavin2 1.235368e-53 2.0293272 0.015 0.210 3.706103e-50 CTL_TRT
## Rph3al 1.521537e-53 2.1623489 0.011 0.150 4.564610e-50 CTL_TRT
## Vit 2.012857e-53 0.2714113 0.025 0.226 6.038570e-50 CTL_TRT
## Gm12648 2.467669e-53 3.9192541 0.021 0.119 7.403006e-50 CTL_TRT
## Ahrr 3.240538e-53 4.1517975 0.021 0.157 9.721615e-50 CTL_TRT
## Kit 4.705766e-53 2.0672854 0.234 0.239 1.411730e-49 CTL_TRT
## Bmp5 5.991310e-53 1.8617276 0.008 0.211 1.797393e-49 CTL_TRT
## Grrp1 7.045529e-53 -0.8346417 0.016 0.126 2.113659e-49 CTL_TRT
## Prag1 2.354777e-52 4.1734888 0.036 0.182 7.064330e-49 CTL_TRT
## Gm16070 2.567978e-52 4.5089689 0.004 0.146 7.703935e-49 CTL_TRT
## Col2a1 1.442979e-51 0.9871255 0.003 0.122 4.328938e-48 CTL_TRT
## Inhbb 4.020402e-51 0.3479199 0.023 0.143 1.206121e-47 CTL_TRT
## Prlr 4.852361e-51 0.9099403 0.059 0.186 1.455708e-47 CTL_TRT
## B130034C11Rik 6.131855e-51 2.5151036 0.016 0.174 1.839556e-47 CTL_TRT
## Irf7 1.047248e-50 0.3448232 0.020 0.218 3.141744e-47 CTL_TRT
## Col19a1 1.099324e-50 1.6522049 0.055 0.191 3.297971e-47 CTL_TRT
## S1pr1 1.108775e-50 -1.7107588 0.093 0.207 3.326324e-47 CTL_TRT
## Cav1 1.388895e-50 -0.6992795 0.088 0.217 4.166685e-47 CTL_TRT
## 1700008O03Rik 1.420940e-50 3.2782596 0.035 0.225 4.262820e-47 CTL_TRT
## Col6a2 3.978953e-50 1.5063342 0.033 0.158 1.193686e-46 CTL_TRT
## Ccdc125 5.646359e-50 1.7578263 0.019 0.107 1.693908e-46 CTL_TRT
## M1ap 1.278349e-49 2.3999984 0.068 0.115 3.835046e-46 CTL_TRT
## Loxl2 1.463641e-49 3.2630418 0.076 0.189 4.390922e-46 CTL_TRT
## Ube2cbp 1.595448e-49 4.3577168 0.034 0.221 4.786343e-46 CTL_TRT
## Cdr1os 1.693309e-49 3.8012545 0.358 0.298 5.079927e-46 CTL_TRT
## Ier2 1.708951e-49 -1.4009482 0.236 0.281 5.126852e-46 CTL_TRT
## Gm43507 1.774158e-49 3.8446863 0.003 0.136 5.322474e-46 CTL_TRT
## Gm20616 1.888479e-49 4.3491105 0.055 0.102 5.665437e-46 CTL_TRT
## Nlrp12 2.207707e-49 1.0369036 0.106 0.179 6.623121e-46 CTL_TRT
## Tmod3 2.353843e-49 2.3205072 0.283 0.267 7.061529e-46 CTL_TRT
## Aim2 2.527019e-49 3.6623966 0.011 0.208 7.581056e-46 CTL_TRT
## Rreb1 2.550631e-49 3.0968863 0.033 0.187 7.651892e-46 CTL_TRT
## Macrod2os1 5.013867e-49 4.5134525 0.004 0.164 1.504160e-45 CTL_TRT
## Clec2d 5.522733e-49 -2.2329193 0.032 0.184 1.656820e-45 CTL_TRT
## Ckmt2 5.716984e-49 2.0782142 0.040 0.118 1.715095e-45 CTL_TRT
## Hopx 6.745202e-49 2.3487588 0.275 0.309 2.023561e-45 CTL_TRT
## Sox7 1.811814e-48 2.1254180 0.003 0.126 5.435441e-45 CTL_TRT
## Mastl 2.514993e-48 4.6775961 0.013 0.204 7.544978e-45 CTL_TRT
## Spin4 3.059835e-48 2.5341017 0.036 0.119 9.179505e-45 CTL_TRT
## Clic6 3.307536e-48 2.1416832 0.026 0.102 9.922607e-45 CTL_TRT
## Cbln2 3.368289e-48 3.0308647 0.078 0.138 1.010487e-44 CTL_TRT
## Mir155hg 3.831835e-48 1.7843931 0.005 0.235 1.149550e-44 CTL_TRT
## 4930549C15Rik 3.913966e-48 4.7015967 0.005 0.103 1.174190e-44 CTL_TRT
## Gm19409 5.902746e-48 2.7020790 0.101 0.181 1.770824e-44 CTL_TRT
## Lcn2 1.677633e-47 1.4400387 0.004 0.128 5.032899e-44 CTL_TRT
## Mgat4c 3.516508e-47 1.8967150 0.116 0.118 1.054952e-43 CTL_TRT
## Gpc3 3.516719e-47 1.8608477 0.057 0.157 1.055016e-43 CTL_TRT
## Fzd7 7.181332e-47 0.7937087 0.109 0.177 2.154400e-43 CTL_TRT
## Aspn 7.590590e-47 1.2656707 0.007 0.102 2.277177e-43 CTL_TRT
## Gm4951 1.147696e-46 1.3564579 0.037 0.130 3.443087e-43 CTL_TRT
## Gm16222 1.328121e-46 1.7027990 0.009 0.174 3.984362e-43 CTL_TRT
## Kcnmb2 1.767351e-46 1.7081648 0.148 0.166 5.302053e-43 CTL_TRT
## Ccnd1 1.901728e-46 -2.8400048 0.110 0.185 5.705185e-43 CTL_TRT
## Cldn11 2.110103e-46 -3.3778667 0.020 0.127 6.330308e-43 CTL_TRT
## Exoc6 2.231437e-46 3.2790500 0.179 0.196 6.694312e-43 CTL_TRT
## Baz1a 2.439915e-46 4.4288409 0.136 0.203 7.319744e-43 CTL_TRT
## Ly6c2 2.462865e-46 2.3137607 0.017 0.108 7.388594e-43 CTL_TRT
## Efhd1 2.505400e-46 0.9916062 0.022 0.137 7.516201e-43 CTL_TRT
## Id1 3.432702e-46 2.8611019 0.058 0.162 1.029811e-42 CTL_TRT
## Slc36a2 4.074127e-46 2.9853573 0.028 0.148 1.222238e-42 CTL_TRT
## Slc39a10 4.181956e-46 2.2931713 0.229 0.233 1.254587e-42 CTL_TRT
## Shroom4 4.218453e-46 4.4820899 0.031 0.155 1.265536e-42 CTL_TRT
## Gm32828 4.422663e-46 3.4247949 0.004 0.107 1.326799e-42 CTL_TRT
## Gm48512 4.626300e-46 2.3535129 0.016 0.144 1.387890e-42 CTL_TRT
## Mrvi1 5.389242e-46 0.5670210 0.031 0.154 1.616773e-42 CTL_TRT
## Lgals1 5.480022e-46 -1.4928491 0.379 0.442 1.644007e-42 CTL_TRT
## Slco1c1 6.103113e-46 3.7659778 0.024 0.147 1.830934e-42 CTL_TRT
## A330008L17Rik 7.867828e-46 1.5542507 0.046 0.101 2.360348e-42 CTL_TRT
## Vgll3 1.011519e-45 3.1051998 0.037 0.169 3.034556e-42 CTL_TRT
## Gm38335 1.345521e-45 0.5907708 0.028 0.122 4.036562e-42 CTL_TRT
## Tspo 1.354087e-45 -2.9608086 0.249 0.248 4.062261e-42 CTL_TRT
## Pcdh15 2.489157e-45 1.8276756 0.078 0.114 7.467471e-42 CTL_TRT
## Gramd3 2.899410e-45 1.1419935 0.019 0.197 8.698229e-42 CTL_TRT
## Gm47134 3.214747e-45 6.2483954 0.003 0.189 9.644241e-42 CTL_TRT
## Tsc22d2 3.309611e-45 -4.0833090 0.249 0.291 9.928832e-42 CTL_TRT
## Elovl2 3.567131e-45 1.7171788 0.038 0.117 1.070139e-41 CTL_TRT
## C820005J03Rik 3.996277e-45 4.0310058 0.019 0.108 1.198883e-41 CTL_TRT
## Sst 5.896651e-45 -1.3054949 0.115 0.178 1.768995e-41 CTL_TRT
## G530011O06Rik 1.154285e-44 0.7075682 0.061 0.189 3.462855e-41 CTL_TRT
## Sh3bp5 1.218126e-44 2.1879603 0.130 0.248 3.654378e-41 CTL_TRT
## Nyap2 2.054670e-44 4.5279697 0.150 0.143 6.164009e-41 CTL_TRT
## Unc5c 2.635959e-44 2.2493538 0.168 0.172 7.907877e-41 CTL_TRT
## Ncmap 3.972053e-44 1.4922610 0.095 0.178 1.191616e-40 CTL_TRT
## Sfrp4 4.076209e-44 -0.6442540 0.036 0.174 1.222863e-40 CTL_TRT
## Dcn 4.580890e-44 -0.5920862 0.109 0.191 1.374267e-40 CTL_TRT
## Trf 5.201145e-44 2.1861275 0.030 0.128 1.560344e-40 CTL_TRT
## Tgif1 6.079720e-44 -0.3547052 0.039 0.230 1.823916e-40 CTL_TRT
## Nts 6.439016e-44 1.8044691 0.112 0.137 1.931705e-40 CTL_TRT
## AV099323 6.946738e-44 0.8576645 0.008 0.212 2.084021e-40 CTL_TRT
## Agbl2 8.040166e-44 3.1149220 0.004 0.133 2.412050e-40 CTL_TRT
## Lgr5 8.883540e-44 2.4442176 0.110 0.182 2.665062e-40 CTL_TRT
## Hoxb9 9.758592e-44 2.2593447 0.028 0.271 2.927577e-40 CTL_TRT
## Gm20468 1.105287e-43 1.6447221 0.208 0.221 3.315862e-40 CTL_TRT
## Samhd1 1.461286e-43 5.0216221 0.196 0.220 4.383859e-40 CTL_TRT
## Lima1 1.942833e-43 6.9234933 0.156 0.256 5.828498e-40 CTL_TRT
## Fyb2 1.946957e-43 2.6566111 0.072 0.154 5.840871e-40 CTL_TRT
## C330002G04Rik 2.866330e-43 4.2131729 0.026 0.154 8.598991e-40 CTL_TRT
## Pcdh11x 3.584051e-43 0.4522486 0.045 0.229 1.075215e-39 CTL_TRT
## 1700001K19Rik 4.365982e-43 3.8450714 0.014 0.122 1.309795e-39 CTL_TRT
## Sorcs2 5.622636e-43 3.1404581 0.054 0.161 1.686791e-39 CTL_TRT
## Acss1 6.556182e-43 3.0722986 0.055 0.186 1.966855e-39 CTL_TRT
## Rprm 6.757084e-43 -1.4661109 0.189 0.189 2.027125e-39 CTL_TRT
## Foxp2 2.491138e-42 2.1896725 0.056 0.171 7.473413e-39 CTL_TRT
## Cnr1 2.676761e-42 3.4288613 0.135 0.166 8.030282e-39 CTL_TRT
## Ifit1 3.388073e-42 1.5779125 0.188 0.199 1.016422e-38 CTL_TRT
## Hpgd 4.725278e-42 -2.1600951 0.013 0.239 1.417583e-38 CTL_TRT
## Vipr2 5.223803e-42 1.3369633 0.002 0.140 1.567141e-38 CTL_TRT
## Fosl2 7.138499e-42 -5.0044362 0.219 0.221 2.141550e-38 CTL_TRT
## Tenm1 9.220073e-42 -0.8201139 0.222 0.218 2.766022e-38 CTL_TRT
## Gbp7 9.408355e-42 -3.8910893 0.077 0.181 2.822506e-38 CTL_TRT
## Rsph14 1.020118e-41 3.9712240 0.003 0.126 3.060353e-38 CTL_TRT
## Rab11fip1 1.098371e-41 3.0094325 0.080 0.144 3.295113e-38 CTL_TRT
## Gm31615 1.392541e-41 2.8544220 0.010 0.141 4.177623e-38 CTL_TRT
## Adcy8 1.552848e-41 2.7960868 0.050 0.102 4.658545e-38 CTL_TRT
## Nrp2 2.622597e-41 3.2881764 0.158 0.225 7.867792e-38 CTL_TRT
## Col23a1 3.197671e-41 3.2246556 0.085 0.194 9.593012e-38 CTL_TRT
## Cenpp 3.371681e-41 2.7845998 0.031 0.206 1.011504e-37 CTL_TRT
## Pik3r5 5.016471e-41 1.7100464 0.004 0.156 1.504941e-37 CTL_TRT
## Hdc 6.083712e-41 1.4957471 0.005 0.113 1.825114e-37 CTL_TRT
## Entpd2 7.007520e-41 4.1601362 0.060 0.218 2.102256e-37 CTL_TRT
## Ppil6 9.468461e-41 2.9155123 0.047 0.186 2.840538e-37 CTL_TRT
## Tmem37 9.848112e-41 2.4123186 0.006 0.160 2.954434e-37 CTL_TRT
## Kcne4 1.247055e-40 0.7991805 0.011 0.151 3.741164e-37 CTL_TRT
## Gm26512 1.444619e-40 1.7879998 0.018 0.125 4.333857e-37 CTL_TRT
## Spp1 1.873591e-40 2.4158785 0.257 0.306 5.620772e-37 CTL_TRT
## Sec14l5 2.006410e-40 1.6923285 0.011 0.217 6.019230e-37 CTL_TRT
## Slc8a1 2.092293e-40 4.0549341 0.145 0.164 6.276879e-37 CTL_TRT
## 4933439C10Rik 3.077827e-40 3.5646738 0.233 0.173 9.233481e-37 CTL_TRT
## Ccdc13 3.533509e-40 2.3758731 0.022 0.154 1.060053e-36 CTL_TRT
## Asap3 3.576170e-40 3.9699780 0.048 0.240 1.072851e-36 CTL_TRT
## Arc 3.734279e-40 1.1256292 0.044 0.205 1.120284e-36 CTL_TRT
## Prim1 4.437851e-40 3.1697958 0.044 0.214 1.331355e-36 CTL_TRT
## Slc25a20 4.985747e-40 4.3730449 0.071 0.193 1.495724e-36 CTL_TRT
## Cd14 5.109147e-40 2.2250128 0.024 0.228 1.532744e-36 CTL_TRT
## Emid1 6.534855e-40 1.7935341 0.030 0.229 1.960456e-36 CTL_TRT
## Hmmr 7.779323e-40 2.2819365 0.002 0.184 2.333797e-36 CTL_TRT
## Med1 8.708863e-40 3.1180798 0.162 0.221 2.612659e-36 CTL_TRT
## Cd163 1.629002e-39 3.4153971 0.005 0.104 4.887007e-36 CTL_TRT
## Inpp4b 1.825269e-39 1.8375878 0.016 0.103 5.475807e-36 CTL_TRT
## Il1rapl2 2.128976e-39 3.2688802 0.080 0.112 6.386927e-36 CTL_TRT
## P2ry1 2.669308e-39 1.3470843 0.155 0.143 8.007925e-36 CTL_TRT
## A730049H05Rik 3.065044e-39 3.3193301 0.017 0.142 9.195133e-36 CTL_TRT
## Vwc2l 3.208639e-39 0.6410658 0.069 0.121 9.625916e-36 CTL_TRT
## Col6a3 4.414606e-39 1.4783407 0.033 0.200 1.324382e-35 CTL_TRT
## Synpo2 5.341558e-39 2.4978235 0.047 0.131 1.602467e-35 CTL_TRT
## Pde8b 6.317509e-39 3.3785271 0.180 0.220 1.895253e-35 CTL_TRT
## Pbk 6.518024e-39 2.5156507 0.003 0.159 1.955407e-35 CTL_TRT
## Prex2 7.141686e-39 1.4160266 0.183 0.247 2.142506e-35 CTL_TRT
## Dcaf17 8.050883e-39 3.2758027 0.064 0.237 2.415265e-35 CTL_TRT
## Cebpb 1.340844e-38 -0.2550934 0.210 0.219 4.022531e-35 CTL_TRT
## Mmp11 1.611354e-38 1.8550609 0.006 0.152 4.834061e-35 CTL_TRT
## Rpgrip1 1.673984e-38 4.3396675 0.195 0.223 5.021951e-35 CTL_TRT
## Bmpr1b 1.689470e-38 0.5365778 0.040 0.162 5.068409e-35 CTL_TRT
## P2rx7 1.789079e-38 1.0074524 0.061 0.187 5.367237e-35 CTL_TRT
## Gxylt2 2.461661e-38 2.6737410 0.006 0.232 7.384982e-35 CTL_TRT
## Mrc2 3.011939e-38 -3.1619230 0.009 0.178 9.035817e-35 CTL_TRT
## Mcl1 3.100000e-38 -3.3260244 0.294 0.330 9.299999e-35 CTL_TRT
## Serpina11 3.350410e-38 4.2032922 0.148 0.166 1.005123e-34 CTL_TRT
## Gm48321 4.978796e-38 1.9061627 0.022 0.145 1.493639e-34 CTL_TRT
## Ramp3 5.593076e-38 1.8092590 0.008 0.233 1.677923e-34 CTL_TRT
## Gm50368 5.751672e-38 6.9471153 0.007 0.161 1.725502e-34 CTL_TRT
## Kcnip1 6.024204e-38 2.8579971 0.156 0.176 1.807261e-34 CTL_TRT
## 9930111J21Rik2 7.969079e-38 3.2605681 0.002 0.115 2.390724e-34 CTL_TRT
## Fam50b 1.022123e-37 4.5419330 0.002 0.125 3.066370e-34 CTL_TRT
## Olfr1420 1.078970e-37 3.0535137 0.034 0.125 3.236909e-34 CTL_TRT
## Slc6a11 1.448316e-37 2.9882976 0.033 0.175 4.344947e-34 CTL_TRT
## Csf1r 1.578981e-37 -0.9938509 0.010 0.107 4.736944e-34 CTL_TRT
## Myct1 1.705341e-37 3.0083444 0.006 0.122 5.116024e-34 CTL_TRT
## Stk38 1.755054e-37 5.1058103 0.177 0.192 5.265162e-34 CTL_TRT
## Slc6a6 2.458380e-37 1.8157634 0.064 0.194 7.375140e-34 CTL_TRT
## Sgms1 2.918858e-37 3.6436773 0.249 0.251 8.756573e-34 CTL_TRT
## Parn 3.787457e-37 4.0597331 0.140 0.197 1.136237e-33 CTL_TRT
## Gm15929 4.779012e-37 2.8058496 0.003 0.178 1.433704e-33 CTL_TRT
## Malrd1 5.444878e-37 2.3519585 0.033 0.144 1.633463e-33 CTL_TRT
## Rasgrf2 6.462477e-37 1.6873677 0.098 0.160 1.938743e-33 CTL_TRT
## Robo1 7.690715e-37 1.7208183 0.141 0.113 2.307214e-33 CTL_TRT
## Slc1a5 8.953172e-37 1.0505241 0.097 0.177 2.685952e-33 CTL_TRT
## Ifih1 1.049612e-36 1.0929854 0.049 0.177 3.148836e-33 CTL_TRT
## Gm35188 1.273132e-36 4.1302434 0.039 0.170 3.819396e-33 CTL_TRT
## Tspan12 1.555268e-36 2.4280436 0.139 0.188 4.665805e-33 CTL_TRT
## Mertk 1.619646e-36 1.8187752 0.073 0.164 4.858938e-33 CTL_TRT
## Spint2 1.633195e-36 -0.2792070 0.254 0.228 4.899585e-33 CTL_TRT
## Pde4c 2.717552e-36 1.4096600 0.084 0.142 8.152655e-33 CTL_TRT
## Carf 2.982229e-36 1.0086609 0.225 0.214 8.946688e-33 CTL_TRT
## Dleu2 3.525182e-36 0.9569720 0.080 0.214 1.057554e-32 CTL_TRT
## Gm36037 3.555827e-36 3.6554533 0.163 0.191 1.066748e-32 CTL_TRT
## Map3k5 4.839499e-36 1.6960755 0.263 0.278 1.451850e-32 CTL_TRT
## Fcrls 4.883773e-36 3.0874731 0.005 0.103 1.465132e-32 CTL_TRT
## Tafa4 4.957256e-36 1.3908358 0.153 0.110 1.487177e-32 CTL_TRT
## Tor1aip1 5.125368e-36 8.3223280 0.154 0.229 1.537610e-32 CTL_TRT
## Psmb8 6.894798e-36 1.8384842 0.179 0.194 2.068439e-32 CTL_TRT
## Prx 8.129463e-36 -0.2966485 0.172 0.220 2.438839e-32 CTL_TRT
## Lrrc4b 8.979129e-36 1.1879909 0.048 0.240 2.693739e-32 CTL_TRT
## Runx3 1.069099e-35 2.1605890 0.031 0.197 3.207298e-32 CTL_TRT
## Ptprk 1.131579e-35 2.2380506 0.119 0.146 3.394737e-32 CTL_TRT
## Shld2 1.137334e-35 4.9120072 0.032 0.232 3.412001e-32 CTL_TRT
## Gm16226 1.190267e-35 2.5903559 0.001 0.228 3.570801e-32 CTL_TRT
## Ecm2 1.382677e-35 2.0572989 0.012 0.134 4.148032e-32 CTL_TRT
## Adamts6 1.466373e-35 0.5791046 0.032 0.184 4.399120e-32 CTL_TRT
## Smim41 1.697284e-35 1.8931652 0.044 0.138 5.091851e-32 CTL_TRT
## Col4a2 2.621737e-35 -1.3109191 0.064 0.195 7.865210e-32 CTL_TRT
## Hck 2.756259e-35 2.1044467 0.008 0.224 8.268777e-32 CTL_TRT
## Tmem176b 2.896456e-35 2.8771523 0.351 0.367 8.689368e-32 CTL_TRT
## Clec3b 3.665367e-35 3.7339927 0.005 0.151 1.099610e-31 CTL_TRT
## AA467197 6.078151e-35 2.4907680 0.003 0.100 1.823445e-31 CTL_TRT
## Slc39a11 6.202348e-35 3.2489207 0.094 0.189 1.860704e-31 CTL_TRT
## C430049B03Rik 7.431141e-35 1.4050627 0.006 0.145 2.229342e-31 CTL_TRT
## Lancl3 1.132374e-34 2.4717137 0.054 0.236 3.397122e-31 CTL_TRT
## Il16 1.353209e-34 2.1408547 0.030 0.172 4.059628e-31 CTL_TRT
## Hpgds 1.357006e-34 3.0230418 0.007 0.142 4.071019e-31 CTL_TRT
## Gm50333 1.386424e-34 1.0515260 0.025 0.162 4.159272e-31 CTL_TRT
## Camkmt 1.416259e-34 5.1853187 0.241 0.249 4.248776e-31 CTL_TRT
## Fxyd7 1.474923e-34 1.2612726 0.316 0.410 4.424770e-31 CTL_TRT
## Spon1 1.967545e-34 4.3505359 0.089 0.141 5.902636e-31 CTL_TRT
## Ntrk1 2.417620e-34 2.5776165 0.302 0.275 7.252860e-31 CTL_TRT
## Gm28379 2.499201e-34 2.9384711 0.018 0.116 7.497603e-31 CTL_TRT
## Rsad1 3.121829e-34 4.2719793 0.043 0.173 9.365487e-31 CTL_TRT
## Gm15336 3.131327e-34 4.2132355 0.003 0.158 9.393982e-31 CTL_TRT
## Gjb1 3.581814e-34 2.6530827 0.011 0.162 1.074544e-30 CTL_TRT
## Blvrb 4.041677e-34 2.0785056 0.280 0.281 1.212503e-30 CTL_TRT
## Heg1 5.811912e-34 0.5377040 0.069 0.174 1.743574e-30 CTL_TRT
## Cabin1 6.981917e-34 4.7294298 0.221 0.231 2.094575e-30 CTL_TRT
## Gabra1 7.386539e-34 2.0235747 0.190 0.166 2.215962e-30 CTL_TRT
## Iqsec2 9.868701e-34 3.0623425 0.229 0.200 2.960610e-30 CTL_TRT
## E230016K23Rik 1.343667e-33 2.6207830 0.020 0.100 4.031002e-30 CTL_TRT
## Gm10636 1.618502e-33 1.9126263 0.007 0.231 4.855505e-30 CTL_TRT
## Hspg2 1.698346e-33 -1.2469435 0.094 0.246 5.095037e-30 CTL_TRT
## Slit2 2.077511e-33 -0.9839647 0.117 0.127 6.232533e-30 CTL_TRT
## Skp1a 2.873188e-33 4.6044898 0.370 0.445 8.619565e-30 CTL_TRT
## Slc16a4 3.067938e-33 0.7463479 0.022 0.182 9.203813e-30 CTL_TRT
## Pcp4l1 3.074988e-33 2.4979152 0.248 0.301 9.224964e-30 CTL_TRT
## Vmn1r85 4.069085e-33 2.6961589 0.049 0.125 1.220726e-29 CTL_TRT
## Pou3f1 4.590069e-33 0.7634231 0.060 0.192 1.377021e-29 CTL_TRT
## S100a11 5.286754e-33 2.2746145 0.317 0.343 1.586026e-29 CTL_TRT
## Srebf2 6.020092e-33 10.6892064 0.384 0.364 1.806028e-29 CTL_TRT
## Lgi3 6.846542e-33 1.7648810 0.224 0.195 2.053963e-29 CTL_TRT
## Hepacam 7.227742e-33 2.8937241 0.057 0.142 2.168323e-29 CTL_TRT
## Swap70 8.993816e-33 1.4109340 0.039 0.252 2.698145e-29 CTL_TRT
## Tlr2 9.955707e-33 0.5515951 0.005 0.108 2.986712e-29 CTL_TRT
## Nfkb1 1.068842e-32 -3.1619766 0.196 0.262 3.206525e-29 CTL_TRT
## Nrip3 1.248624e-32 0.3907532 0.284 0.281 3.745872e-29 CTL_TRT
## Rgs6 1.300965e-32 2.4344363 0.101 0.128 3.902895e-29 CTL_TRT
## Draxin 1.441082e-32 2.8456970 0.031 0.202 4.323246e-29 CTL_TRT
## Rasl11a 1.611445e-32 2.8542874 0.091 0.152 4.834336e-29 CTL_TRT
## Acad10 1.843202e-32 0.8906507 0.121 0.151 5.529607e-29 CTL_TRT
## Rad51b 2.050384e-32 1.2495200 0.019 0.215 6.151152e-29 CTL_TRT
## Brca1 2.135194e-32 2.1665045 0.061 0.118 6.405583e-29 CTL_TRT
## Tagln2 2.416306e-32 2.7629230 0.255 0.282 7.248919e-29 CTL_TRT
## Lrrc7 2.451145e-32 1.5463958 0.038 0.109 7.353436e-29 CTL_TRT
## Sox2 2.776797e-32 1.3824329 0.169 0.241 8.330392e-29 CTL_TRT
## Gfap 3.718723e-32 2.1636364 0.004 0.162 1.115617e-28 CTL_TRT
## Pcdh8 5.033776e-32 2.3164292 0.033 0.144 1.510133e-28 CTL_TRT
## Ubb 5.862608e-32 0.8403433 0.436 0.540 1.758782e-28 CTL_TRT
## Tesc 7.260330e-32 2.3301371 0.285 0.308 2.178099e-28 CTL_TRT
## Slc35f4 8.600860e-32 0.9043937 0.190 0.203 2.580258e-28 CTL_TRT
## Hspb2 9.602848e-32 0.9266426 0.036 0.223 2.880854e-28 CTL_TRT
## Alkal2 9.815686e-32 0.3142296 0.184 0.168 2.944706e-28 CTL_TRT
## Actb 1.030006e-31 3.7036529 0.356 0.449 3.090017e-28 CTL_TRT
## Gfra3 1.088894e-31 1.9540417 0.162 0.195 3.266683e-28 CTL_TRT
## Col16a1 1.174089e-31 0.8728063 0.097 0.176 3.522267e-28 CTL_TRT
## Plxna2 1.199257e-31 0.7020574 0.253 0.279 3.597771e-28 CTL_TRT
## Itm2a 1.397243e-31 -0.9070401 0.121 0.233 4.191729e-28 CTL_TRT
## S100a2 1.406028e-31 2.6702146 0.022 0.200 4.218085e-28 CTL_TRT
## Spry2 1.539565e-31 5.3509445 0.206 0.186 4.618694e-28 CTL_TRT
## Retnlg 2.669007e-31 0.7086188 0.002 0.134 8.007022e-28 CTL_TRT
## Xaf1 4.236433e-31 3.9358320 0.150 0.193 1.270930e-27 CTL_TRT
## Fabp3 4.748895e-31 1.0612373 0.311 0.293 1.424669e-27 CTL_TRT
## Kif19a 1.039298e-30 3.9783771 0.021 0.210 3.117895e-27 CTL_TRT
## 1700013F07Rik 1.047791e-30 2.0766267 0.007 0.216 3.143374e-27 CTL_TRT
## Dpp4 1.085631e-30 1.6229979 0.001 0.118 3.256892e-27 CTL_TRT
## Cntn3 1.229512e-30 4.7154709 0.171 0.171 3.688535e-27 CTL_TRT
## Sema7a 1.316268e-30 1.2111741 0.117 0.173 3.948804e-27 CTL_TRT
## Ctnnal1 1.362223e-30 -0.7419805 0.184 0.285 4.086670e-27 CTL_TRT
## 4930556J24Rik 1.388181e-30 3.3350151 0.034 0.252 4.164543e-27 CTL_TRT
## Kirrel 1.692890e-30 3.1906230 0.053 0.155 5.078670e-27 CTL_TRT
## Creb5 1.750963e-30 4.0352092 0.157 0.208 5.252890e-27 CTL_TRT
## Klhl24 2.298084e-30 7.0594502 0.312 0.289 6.894251e-27 CTL_TRT
## Smoc1 2.902617e-30 -1.2280078 0.040 0.212 8.707851e-27 CTL_TRT
## Gm26542 3.021385e-30 3.9749608 0.014 0.167 9.064155e-27 CTL_TRT
## Prkcb 3.031737e-30 1.8126804 0.196 0.207 9.095212e-27 CTL_TRT
## Hacd4 3.293066e-30 1.2629750 0.012 0.280 9.879199e-27 CTL_TRT
## Ms4a6c 5.392435e-30 5.6439187 0.006 0.130 1.617730e-26 CTL_TRT
## Ccnd2 6.348870e-30 0.4818137 0.036 0.188 1.904661e-26 CTL_TRT
## Cysltr2 8.698110e-30 0.9067136 0.108 0.150 2.609433e-26 CTL_TRT
## Farp1 8.988548e-30 5.3785378 0.227 0.211 2.696564e-26 CTL_TRT
## Plcl1 1.011981e-29 -0.9797597 0.182 0.196 3.035943e-26 CTL_TRT
## Cd34 1.082637e-29 -1.8661161 0.075 0.164 3.247910e-26 CTL_TRT
## Prdm16 1.363020e-29 -2.6075405 0.101 0.202 4.089060e-26 CTL_TRT
## Grm3 1.866145e-29 1.6102935 0.057 0.148 5.598434e-26 CTL_TRT
## Cacna1e 3.617048e-29 1.8911332 0.076 0.116 1.085114e-25 CTL_TRT
## Nr5a2 5.139916e-29 0.8622198 0.004 0.108 1.541975e-25 CTL_TRT
## Gadd45b 5.226908e-29 -0.3107990 0.272 0.336 1.568073e-25 CTL_TRT
## Dixdc1 5.815076e-29 3.8180099 0.032 0.225 1.744523e-25 CTL_TRT
## Mfge8 7.437657e-29 2.0850343 0.023 0.204 2.231297e-25 CTL_TRT
## Efemp1 8.424094e-29 -0.5930935 0.083 0.185 2.527228e-25 CTL_TRT
## Pdgfd 8.491066e-29 0.3082879 0.013 0.110 2.547320e-25 CTL_TRT
## Ggt5 8.578403e-29 4.1456923 0.042 0.170 2.573521e-25 CTL_TRT
## Tek 8.994424e-29 1.8694239 0.015 0.151 2.698327e-25 CTL_TRT
## Lars2 9.177354e-29 6.9410032 0.310 0.426 2.753206e-25 CTL_TRT
## B430010I23Rik 1.055456e-28 2.2457732 0.012 0.130 3.166369e-25 CTL_TRT
## Itga2 1.082034e-28 0.8875119 0.023 0.191 3.246101e-25 CTL_TRT
## Lynx1 1.312496e-28 0.5360923 0.292 0.279 3.937489e-25 CTL_TRT
## Abcb1a 1.821241e-28 -0.4069283 0.022 0.101 5.463722e-25 CTL_TRT
## Zfp346 3.331899e-28 7.3688428 0.075 0.169 9.995697e-25 CTL_TRT
## Nsun2 3.359944e-28 5.9515662 0.170 0.229 1.007983e-24 CTL_TRT
## Rarres1 3.582719e-28 -0.6357909 0.182 0.162 1.074816e-24 CTL_TRT
## Ndst3 3.983070e-28 -0.8813717 0.219 0.225 1.194921e-24 CTL_TRT
## Gm4566 4.083030e-28 1.9139684 0.002 0.148 1.224909e-24 CTL_TRT
## Ankfn1 4.573762e-28 2.2256446 0.025 0.165 1.372129e-24 CTL_TRT
## Mfap3l 4.586108e-28 0.5989792 0.181 0.251 1.375832e-24 CTL_TRT
## Fxyd5 5.778671e-28 1.2857291 0.080 0.188 1.733601e-24 CTL_TRT
## Gm15886 9.591265e-28 4.0509119 0.030 0.196 2.877379e-24 CTL_TRT
## Gsta2 1.023507e-27 3.1355397 0.005 0.133 3.070522e-24 CTL_TRT
## Tmem163 1.054343e-27 1.4940903 0.086 0.140 3.163029e-24 CTL_TRT
## Kitl 1.092621e-27 0.9065955 0.178 0.224 3.277864e-24 CTL_TRT
## Cdc42ep5 1.096942e-27 0.8735675 0.060 0.185 3.290827e-24 CTL_TRT
## Dusp18 1.196785e-27 2.9413779 0.067 0.154 3.590354e-24 CTL_TRT
## Dapp1 1.229665e-27 2.2539767 0.004 0.138 3.688995e-24 CTL_TRT
## Chn2 1.321400e-27 3.3439231 0.111 0.217 3.964199e-24 CTL_TRT
## Copz2 1.389519e-27 4.0058349 0.055 0.213 4.168557e-24 CTL_TRT
## Nefh 1.607462e-27 2.9540002 0.352 0.439 4.822386e-24 CTL_TRT
## Th 2.025072e-27 3.5485002 0.127 0.116 6.075217e-24 CTL_TRT
## 4930422I22Rik 2.130912e-27 1.5355706 0.015 0.158 6.392736e-24 CTL_TRT
## Shisa6 2.782593e-27 0.3352189 0.085 0.104 8.347780e-24 CTL_TRT
## 4921511C10Rik 2.928431e-27 3.0552038 0.019 0.179 8.785292e-24 CTL_TRT
## Il31ra 3.398120e-27 1.3335806 0.129 0.158 1.019436e-23 CTL_TRT
## Zfp804a 3.429724e-27 1.6616765 0.182 0.172 1.028917e-23 CTL_TRT
## Cdhr1 3.901047e-27 5.6940539 0.163 0.160 1.170314e-23 CTL_TRT
## Gpx3 4.606790e-27 1.6543824 0.181 0.205 1.382037e-23 CTL_TRT
## Pclaf 4.731087e-27 -0.9072431 0.014 0.179 1.419326e-23 CTL_TRT
## C4b 9.036546e-27 0.6420011 0.036 0.184 2.710964e-23 CTL_TRT
## Tril 9.733314e-27 2.0905303 0.022 0.153 2.919994e-23 CTL_TRT
## Frem1 1.097898e-26 1.3136660 0.020 0.206 3.293695e-23 CTL_TRT
## Cpne9 1.259851e-26 6.8154330 0.025 0.217 3.779552e-23 CTL_TRT
## Cdc14a 1.327436e-26 2.5158909 0.054 0.138 3.982309e-23 CTL_TRT
## E4f1 1.514820e-26 5.2232770 0.121 0.180 4.544461e-23 CTL_TRT
## Gm26917 2.374728e-26 2.4017606 0.091 0.187 7.124184e-23 CTL_TRT
## Sipa1l1 2.498761e-26 0.8045875 0.112 0.221 7.496283e-23 CTL_TRT
## Pml 2.824906e-26 4.6718057 0.053 0.139 8.474717e-23 CTL_TRT
## Nr1d2 3.579918e-26 3.3817010 0.204 0.201 1.073975e-22 CTL_TRT
## Mndal 5.042546e-26 1.2371966 0.011 0.135 1.512764e-22 CTL_TRT
## Gldn 6.287412e-26 -1.4848289 0.036 0.150 1.886224e-22 CTL_TRT
## Mmp2 7.541593e-26 -1.4496953 0.010 0.116 2.262478e-22 CTL_TRT
## Des 8.311763e-26 0.9391005 0.003 0.134 2.493529e-22 CTL_TRT
## Irf8 8.737989e-26 1.2192771 0.009 0.156 2.621397e-22 CTL_TRT
## Dennd5b 8.857946e-26 3.9287595 0.248 0.236 2.657384e-22 CTL_TRT
## Slc25a21 9.131854e-26 4.3893356 0.006 0.213 2.739556e-22 CTL_TRT
## Epha4 1.053368e-25 1.8735406 0.034 0.195 3.160105e-22 CTL_TRT
## Ptpn11 1.167103e-25 2.5506586 0.270 0.281 3.501308e-22 CTL_TRT
## Atp10a 1.213474e-25 1.6332551 0.030 0.155 3.640423e-22 CTL_TRT
## Rab38 1.235565e-25 0.7631598 0.024 0.246 3.706695e-22 CTL_TRT
## Atp2b4 1.433522e-25 -1.5334855 0.217 0.233 4.300565e-22 CTL_TRT
## Gm44257 1.523074e-25 1.5016733 0.077 0.171 4.569221e-22 CTL_TRT
## Ptprn2 1.571990e-25 2.4162657 0.154 0.175 4.715970e-22 CTL_TRT
## Mme 2.018593e-25 2.6787980 0.046 0.228 6.055778e-22 CTL_TRT
## Tnfrsf1a 2.494548e-25 1.2754777 0.055 0.235 7.483643e-22 CTL_TRT
## Lpxn 2.495084e-25 1.3725248 0.008 0.168 7.485253e-22 CTL_TRT
## Calca 2.888019e-25 0.7392677 0.277 0.313 8.664058e-22 CTL_TRT
## Tac1 3.027364e-25 0.7880549 0.231 0.244 9.082092e-22 CTL_TRT
## Cdkn1c 3.037325e-25 1.4056810 0.008 0.230 9.111974e-22 CTL_TRT
## Ptprcap 3.224917e-25 0.9826943 0.001 0.136 9.674750e-22 CTL_TRT
## Phf6 3.376273e-25 4.8901524 0.231 0.244 1.012882e-21 CTL_TRT
## Chad 3.391615e-25 2.4454699 0.002 0.142 1.017485e-21 CTL_TRT
## Hmcn1 3.544291e-25 0.9585394 0.084 0.179 1.063287e-21 CTL_TRT
## Npy1r 3.756069e-25 1.5249897 0.115 0.148 1.126821e-21 CTL_TRT
## Eps8l2 7.617419e-25 0.7164068 0.009 0.128 2.285226e-21 CTL_TRT
## Gm32036 8.015570e-25 2.3985714 0.011 0.120 2.404671e-21 CTL_TRT
## Htra1 8.015924e-25 -2.2944970 0.294 0.261 2.404777e-21 CTL_TRT
## Sort1 8.332389e-25 2.1490907 0.152 0.241 2.499717e-21 CTL_TRT
## Gbp8 9.229543e-25 3.0505576 0.005 0.196 2.768863e-21 CTL_TRT
## Bex1 9.411358e-25 0.9844437 0.214 0.200 2.823407e-21 CTL_TRT
## Fam178b 9.502373e-25 1.7102223 0.134 0.190 2.850712e-21 CTL_TRT
## Dpyd 1.047395e-24 0.4334808 0.236 0.258 3.142184e-21 CTL_TRT
## Nxpe4 1.408789e-24 0.9154762 0.174 0.191 4.226367e-21 CTL_TRT
## Car2 1.544962e-24 4.4552438 0.161 0.232 4.634886e-21 CTL_TRT
## Kcnc4 1.559569e-24 1.1392369 0.276 0.240 4.678706e-21 CTL_TRT
## Cntnap4 1.648792e-24 1.2999683 0.221 0.199 4.946375e-21 CTL_TRT
## Osmr 1.700301e-24 -0.3477382 0.159 0.159 5.100903e-21 CTL_TRT
## F13a1 1.864747e-24 2.3697184 0.012 0.183 5.594240e-21 CTL_TRT
## Iqcb1 2.018101e-24 5.0650352 0.189 0.231 6.054303e-21 CTL_TRT
## Kcnj16 2.048324e-24 2.1300906 0.029 0.162 6.144973e-21 CTL_TRT
## Dach2 2.324398e-24 -0.4111028 0.013 0.133 6.973194e-21 CTL_TRT
## Esrrg 2.350273e-24 0.5157241 0.110 0.097 7.050820e-21 CTL_TRT
## 4930523C07Rik 2.456972e-24 2.3775655 0.032 0.203 7.370917e-21 CTL_TRT
## Kazn 2.523901e-24 3.5410113 0.198 0.186 7.571703e-21 CTL_TRT
## Rps6ka5 2.714362e-24 0.3700657 0.201 0.214 8.143085e-21 CTL_TRT
## Zfpm2 2.719540e-24 1.3522058 0.113 0.198 8.158621e-21 CTL_TRT
## Fabp7 2.744883e-24 1.1965677 0.322 0.271 8.234649e-21 CTL_TRT
## A530076I17Rik 2.902049e-24 3.9361861 0.018 0.236 8.706146e-21 CTL_TRT
## Gm14636 3.026475e-24 2.8394469 0.005 0.208 9.079424e-21 CTL_TRT
## Gm38560 3.054395e-24 3.1082854 0.221 0.209 9.163185e-21 CTL_TRT
## Cdo1 3.902962e-24 4.0964774 0.074 0.169 1.170888e-20 CTL_TRT
## Mrc1 3.971092e-24 0.9011546 0.014 0.102 1.191328e-20 CTL_TRT
## Itpr2 5.198143e-24 2.1606355 0.017 0.178 1.559443e-20 CTL_TRT
## Ccl7 5.387480e-24 0.4297727 0.018 0.162 1.616244e-20 CTL_TRT
## Gm44129 5.525220e-24 2.6265458 0.001 0.188 1.657566e-20 CTL_TRT
## 5330434G04Rik 6.571424e-24 0.4582226 0.238 0.214 1.971427e-20 CTL_TRT
## Zfp36 6.644974e-24 1.3752536 0.297 0.300 1.993492e-20 CTL_TRT
## Hs3st4 6.817391e-24 0.8581134 0.036 0.155 2.045217e-20 CTL_TRT
## Oaf 6.989834e-24 2.0768878 0.052 0.220 2.096950e-20 CTL_TRT
## H2-K1 7.973325e-24 -2.1085317 0.316 0.329 2.391998e-20 CTL_TRT
## Zfp318 9.497560e-24 4.2980777 0.137 0.209 2.849268e-20 CTL_TRT
## Mlc1 9.860433e-24 2.9166012 0.069 0.182 2.958130e-20 CTL_TRT
## Plekhg2 1.158242e-23 3.7193407 0.056 0.230 3.474726e-20 CTL_TRT
## Tafa1 1.219042e-23 0.6962156 0.164 0.181 3.657125e-20 CTL_TRT
## 2310014F06Rik 1.435343e-23 2.4052890 0.019 0.224 4.306028e-20 CTL_TRT
## Ifi203 1.599505e-23 1.3748654 0.017 0.165 4.798515e-20 CTL_TRT
## Adamts17 1.732091e-23 2.5829767 0.064 0.172 5.196272e-20 CTL_TRT
## Mfap5 1.796906e-23 1.1591493 0.041 0.150 5.390717e-20 CTL_TRT
## Ddr2 1.962407e-23 1.1951848 0.027 0.210 5.887220e-20 CTL_TRT
## Meis2 2.224954e-23 2.9843493 0.111 0.196 6.674862e-20 CTL_TRT
## Prtn3 2.649874e-23 2.0346051 0.009 0.166 7.949621e-20 CTL_TRT
## Plat 2.699971e-23 0.6848404 0.041 0.248 8.099912e-20 CTL_TRT
## Wfdc18 3.040176e-23 1.4215212 0.008 0.225 9.120528e-20 CTL_TRT
## Bmx 3.129261e-23 3.8429791 0.002 0.119 9.387784e-20 CTL_TRT
## Tmsb4x 3.760099e-23 2.0090443 0.358 0.404 1.128030e-19 CTL_TRT
## Ryr2 5.685085e-23 1.7811553 0.177 0.158 1.705526e-19 CTL_TRT
## Acsbg1 6.171770e-23 0.8289279 0.191 0.217 1.851531e-19 CTL_TRT
## Gm13479 6.740228e-23 1.7864050 0.002 0.152 2.022068e-19 CTL_TRT
## Ptgfrn 6.780195e-23 -1.0582777 0.136 0.211 2.034059e-19 CTL_TRT
## Myl9 7.272231e-23 -0.4168568 0.041 0.139 2.181669e-19 CTL_TRT
## Dach1 7.327634e-23 0.7585875 0.121 0.124 2.198290e-19 CTL_TRT
## Pbxip1 9.216899e-23 3.2587320 0.056 0.138 2.765070e-19 CTL_TRT
## Asic3 1.157154e-22 1.8492032 0.169 0.199 3.471462e-19 CTL_TRT
## Cxcl9 1.261489e-22 0.6806296 0.003 0.142 3.784467e-19 CTL_TRT
## Lmna 1.299461e-22 -2.2653778 0.404 0.433 3.898384e-19 CTL_TRT
## Fkbp9 1.534965e-22 4.8858964 0.124 0.191 4.604895e-19 CTL_TRT
## Adgrl2 1.591990e-22 3.4057806 0.103 0.187 4.775970e-19 CTL_TRT
## Fgd5 1.607617e-22 -0.2501904 0.010 0.184 4.822852e-19 CTL_TRT
## Tspan8 2.091175e-22 2.3396619 0.239 0.223 6.273524e-19 CTL_TRT
## Gm34684 2.167556e-22 2.4558778 0.002 0.189 6.502667e-19 CTL_TRT
## Dlg2 2.404491e-22 1.3601081 0.198 0.169 7.213474e-19 CTL_TRT
## Kcnt2 2.833745e-22 0.9885396 0.083 0.143 8.501236e-19 CTL_TRT
## Mylk 3.685704e-22 1.2179806 0.030 0.146 1.105711e-18 CTL_TRT
## Ptprm 3.716019e-22 0.5999291 0.232 0.224 1.114806e-18 CTL_TRT
## C2cd2 4.240803e-22 5.4465296 0.091 0.182 1.272241e-18 CTL_TRT
## Wdr72 4.247643e-22 2.2082223 0.031 0.262 1.274293e-18 CTL_TRT
## Stxbp5l 5.007566e-22 2.1069360 0.127 0.201 1.502270e-18 CTL_TRT
## Calb1 5.078562e-22 0.8194752 0.148 0.202 1.523569e-18 CTL_TRT
## Clec2l 5.248186e-22 0.6098015 0.332 0.330 1.574456e-18 CTL_TRT
## Ifi207 6.180405e-22 2.7742136 0.007 0.102 1.854121e-18 CTL_TRT
## Col12a1 6.705644e-22 1.1218210 0.125 0.221 2.011693e-18 CTL_TRT
## Cfap57 7.537575e-22 2.3673521 0.134 0.152 2.261272e-18 CTL_TRT
## Nt5e 8.887292e-22 -1.0526031 0.156 0.214 2.666188e-18 CTL_TRT
## 5330438D12Rik 8.950759e-22 -3.2104786 0.081 0.159 2.685228e-18 CTL_TRT
## Gm2245 1.037375e-21 1.7470670 0.090 0.129 3.112126e-18 CTL_TRT
## Zfp36l2 1.049873e-21 0.5409083 0.156 0.279 3.149618e-18 CTL_TRT
## Fstl5 1.424249e-21 2.2228471 0.154 0.152 4.272747e-18 CTL_TRT
## Htr1f 1.731296e-21 1.3423843 0.133 0.144 5.193888e-18 CTL_TRT
## 6330411D24Rik 1.860904e-21 3.0174378 0.117 0.134 5.582713e-18 CTL_TRT
## Slfn8 1.876323e-21 1.0620929 0.002 0.148 5.628970e-18 CTL_TRT
## 9530026P05Rik 1.916413e-21 1.2023368 0.178 0.212 5.749240e-18 CTL_TRT
## Ier3 2.019543e-21 0.5408533 0.349 0.358 6.058630e-18 CTL_TRT
## S100a4 2.119914e-21 1.3696117 0.308 0.311 6.359742e-18 CTL_TRT
## Nrg3os 2.336061e-21 0.7115027 0.201 0.174 7.008184e-18 CTL_TRT
## Cyp2j6 3.204684e-21 6.0857320 0.201 0.255 9.614052e-18 CTL_TRT
## Cox6b2 4.375525e-21 1.6950748 0.029 0.208 1.312658e-17 CTL_TRT
## Shank3 5.150059e-21 0.9146021 0.022 0.159 1.545018e-17 CTL_TRT
## Snhg11 6.677268e-21 0.5260432 0.308 0.250 2.003180e-17 CTL_TRT
## Sfrp5 7.040164e-21 1.8497100 0.302 0.253 2.112049e-17 CTL_TRT
## Junb 7.861929e-21 2.8824366 0.399 0.444 2.358579e-17 CTL_TRT
## Vat1l 1.034528e-20 -2.6245455 0.265 0.258 3.103583e-17 CTL_TRT
## Ccdc18 1.123287e-20 3.5521151 0.007 0.198 3.369860e-17 CTL_TRT
## Thy1 1.197214e-20 0.8345067 0.357 0.362 3.591643e-17 CTL_TRT
## Cspg5 1.409831e-20 -1.3564051 0.046 0.160 4.229494e-17 CTL_TRT
## 4930511M06Rik 1.681385e-20 3.6495088 0.006 0.127 5.044154e-17 CTL_TRT
## Specc1 1.940804e-20 2.6032623 0.050 0.208 5.822412e-17 CTL_TRT
## Wwox 2.044688e-20 4.8199730 0.238 0.268 6.134065e-17 CTL_TRT
## Prkch 2.244832e-20 1.9818048 0.055 0.155 6.734497e-17 CTL_TRT
## Arhgap31 2.267037e-20 1.0954147 0.132 0.232 6.801111e-17 CTL_TRT
## Vmn1r181 2.376221e-20 2.0361668 0.022 0.215 7.128663e-17 CTL_TRT
## Has2 2.500509e-20 1.7666531 0.004 0.164 7.501528e-17 CTL_TRT
## Hlf 2.632134e-20 3.2648248 0.022 0.171 7.896401e-17 CTL_TRT
## Gm41609 3.076836e-20 1.2521195 0.240 0.182 9.230507e-17 CTL_TRT
## Trim71 3.230077e-20 3.4198664 0.003 0.148 9.690230e-17 CTL_TRT
## Rab20 3.388774e-20 2.6994101 0.074 0.189 1.016632e-16 CTL_TRT
## S100b 3.783857e-20 0.4406676 0.359 0.439 1.135157e-16 CTL_TRT
## Cacng4 4.925310e-20 5.4555549 0.037 0.166 1.477593e-16 CTL_TRT
## Sash1 5.796012e-20 2.1841339 0.145 0.241 1.738804e-16 CTL_TRT
## Smo 6.181993e-20 1.9906521 0.025 0.194 1.854598e-16 CTL_TRT
## Shb 6.464889e-20 1.9391653 0.014 0.139 1.939467e-16 CTL_TRT
## Btg1 8.674418e-20 1.2111652 0.327 0.376 2.602325e-16 CTL_TRT
## Ngp 1.175761e-19 1.0908225 0.003 0.114 3.527284e-16 CTL_TRT
## Cdk1 1.192668e-19 2.1465579 0.005 0.129 3.578003e-16 CTL_TRT
## S100a16 1.433468e-19 2.3474804 0.223 0.254 4.300403e-16 CTL_TRT
## Srl 1.619330e-19 4.3851182 0.040 0.212 4.857991e-16 CTL_TRT
## Faim2 1.661219e-19 4.0136058 0.230 0.220 4.983657e-16 CTL_TRT
## Angpt1 1.984180e-19 0.4419727 0.026 0.201 5.952539e-16 CTL_TRT
## Pard6g 2.147862e-19 6.5001775 0.043 0.147 6.443587e-16 CTL_TRT
## Gm13889 2.569534e-19 1.9685456 0.342 0.319 7.708601e-16 CTL_TRT
## Mpv17l 2.872567e-19 3.9176978 0.208 0.207 8.617700e-16 CTL_TRT
## Folh1 2.913324e-19 1.5162535 0.060 0.182 8.739971e-16 CTL_TRT
## Ucn2 3.209659e-19 2.1072113 0.002 0.131 9.628976e-16 CTL_TRT
## Id2 4.118144e-19 6.8420975 0.321 0.301 1.235443e-15 CTL_TRT
## Cckar 4.221112e-19 2.9903088 0.089 0.125 1.266334e-15 CTL_TRT
## Pcp4 4.983164e-19 0.8165003 0.360 0.410 1.494949e-15 CTL_TRT
## Ptprb 5.037996e-19 2.8569532 0.019 0.151 1.511399e-15 CTL_TRT
## Gadd45g 5.424529e-19 1.0706795 0.369 0.396 1.627359e-15 CTL_TRT
## Nfasc 5.656637e-19 0.5131864 0.237 0.250 1.696991e-15 CTL_TRT
## Nfatc2 5.763585e-19 2.7031376 0.035 0.164 1.729076e-15 CTL_TRT
## Khdrbs2 5.772159e-19 2.8679830 0.224 0.212 1.731648e-15 CTL_TRT
## Nr3c2 6.311905e-19 2.4528475 0.150 0.217 1.893571e-15 CTL_TRT
## Nt5dc2 8.367710e-19 1.3120625 0.035 0.158 2.510313e-15 CTL_TRT
## Egfl7 8.892143e-19 -1.3682699 0.188 0.192 2.667643e-15 CTL_TRT
## Spry1 1.151487e-18 3.9681382 0.006 0.222 3.454462e-15 CTL_TRT
## Adgre1 1.155567e-18 4.1077975 0.005 0.127 3.466702e-15 CTL_TRT
## Ust 1.363366e-18 1.2420417 0.191 0.222 4.090097e-15 CTL_TRT
## Apbb2 1.643772e-18 5.9145543 0.282 0.288 4.931316e-15 CTL_TRT
## Nwd1 1.715834e-18 4.7950790 0.065 0.218 5.147503e-15 CTL_TRT
## Gm48091 2.096714e-18 6.4894878 0.027 0.215 6.290141e-15 CTL_TRT
## 1700047M11Rik 2.631864e-18 3.4412974 0.114 0.170 7.895592e-15 CTL_TRT
## Pdk4 3.466742e-18 2.3408366 0.031 0.158 1.040023e-14 CTL_TRT
## Trib1 3.468380e-18 2.5041546 0.164 0.187 1.040514e-14 CTL_TRT
## Ptgfr 4.843181e-18 2.4303208 0.093 0.162 1.452954e-14 CTL_TRT
## S100a13 4.926595e-18 -0.5994995 0.380 0.433 1.477979e-14 CTL_TRT
## Pltp 5.139156e-18 2.7569280 0.030 0.115 1.541747e-14 CTL_TRT
## Serpinb1a 5.445098e-18 0.7963055 0.099 0.261 1.633529e-14 CTL_TRT
## Ptpn18 5.910011e-18 -0.9402040 0.010 0.108 1.773003e-14 CTL_TRT
## Cybb 6.073013e-18 0.7078688 0.007 0.146 1.821904e-14 CTL_TRT
## Trim47 6.085734e-18 1.7619854 0.015 0.231 1.825720e-14 CTL_TRT
## Mrpl9 7.322171e-18 6.4182105 0.125 0.171 2.196651e-14 CTL_TRT
## Nrsn1 7.743481e-18 -0.2607531 0.272 0.279 2.323044e-14 CTL_TRT
## Thsd7b 8.929753e-18 1.7704457 0.169 0.136 2.678926e-14 CTL_TRT
## Gda 9.141843e-18 0.2573960 0.130 0.209 2.742553e-14 CTL_TRT
## Pifo 1.007712e-17 1.7956521 0.059 0.120 3.023136e-14 CTL_TRT
## Tagln3 1.020944e-17 0.3087863 0.399 0.395 3.062831e-14 CTL_TRT
## Slc7a2 1.185955e-17 -0.5929332 0.200 0.201 3.557865e-14 CTL_TRT
## Nmnat3 1.382057e-17 2.5466885 0.006 0.211 4.146170e-14 CTL_TRT
## Stxbp6 1.531466e-17 3.0776999 0.108 0.166 4.594399e-14 CTL_TRT
## Gstm2 1.619463e-17 2.5822523 0.012 0.190 4.858390e-14 CTL_TRT
## Fstl1 1.736750e-17 1.4407068 0.366 0.403 5.210249e-14 CTL_TRT
## Gm47507 1.767104e-17 2.0599153 0.005 0.165 5.301312e-14 CTL_TRT
## Gpnmb 1.848622e-17 0.7890646 0.014 0.185 5.545866e-14 CTL_TRT
## Gm26802 1.903435e-17 3.3724612 0.004 0.109 5.710304e-14 CTL_TRT
## Gm17268 1.952627e-17 2.5945491 0.040 0.172 5.857880e-14 CTL_TRT
## Kdr 2.085963e-17 0.5633009 0.012 0.137 6.257890e-14 CTL_TRT
## Gm15398 2.129877e-17 2.0556319 0.003 0.123 6.389631e-14 CTL_TRT
## Eps8 2.444165e-17 1.9868770 0.037 0.170 7.332494e-14 CTL_TRT
## Tafa5 2.801044e-17 -0.5416571 0.162 0.226 8.403133e-14 CTL_TRT
## Rdh12 2.994113e-17 0.7485082 0.009 0.206 8.982338e-14 CTL_TRT
## Tenm4 3.057272e-17 0.6520951 0.233 0.211 9.171815e-14 CTL_TRT
## Kctd12b 3.161785e-17 0.6718458 0.010 0.172 9.485355e-14 CTL_TRT
## Eda 3.203349e-17 0.4209241 0.060 0.168 9.610046e-14 CTL_TRT
## Gria3 3.559111e-17 0.3902816 0.195 0.226 1.067733e-13 CTL_TRT
## Cfap100 4.709053e-17 0.8865826 0.031 0.164 1.412716e-13 CTL_TRT
## Fcgrt 5.078270e-17 1.5215120 0.075 0.179 1.523481e-13 CTL_TRT
## Pgf 5.081120e-17 0.3992009 0.070 0.168 1.524336e-13 CTL_TRT
## Galnt6 5.281120e-17 0.7651361 0.014 0.247 1.584336e-13 CTL_TRT
## Ctsc 5.525926e-17 1.4795617 0.072 0.153 1.657778e-13 CTL_TRT
## Gm13963 5.551150e-17 3.3651329 0.086 0.172 1.665345e-13 CTL_TRT
## Plekhg1 6.645107e-17 0.9363537 0.126 0.168 1.993532e-13 CTL_TRT
## S100a8 7.760770e-17 0.7047305 0.016 0.262 2.328231e-13 CTL_TRT
## Diaph3 8.647530e-17 4.0666152 0.100 0.181 2.594259e-13 CTL_TRT
## Ncf2 8.711587e-17 1.1580925 0.012 0.149 2.613476e-13 CTL_TRT
## Fxyd6 8.761170e-17 -0.3084339 0.252 0.272 2.628351e-13 CTL_TRT
## Phlpp1 9.770311e-17 -4.2828223 0.210 0.258 2.931093e-13 CTL_TRT
## Tmem231 1.246613e-16 2.7948895 0.068 0.162 3.739839e-13 CTL_TRT
## Sipa1l2 1.302033e-16 5.2582802 0.063 0.149 3.906099e-13 CTL_TRT
## Cx3cr1 1.321466e-16 1.3040341 0.028 0.196 3.964399e-13 CTL_TRT
## Nefm 1.388018e-16 4.5383047 0.393 0.443 4.164054e-13 CTL_TRT
## Efr3a 1.411448e-16 5.6671775 0.299 0.254 4.234344e-13 CTL_TRT
## Fgl2 1.538078e-16 1.1296766 0.040 0.199 4.614233e-13 CTL_TRT
## Arpp21 1.603812e-16 2.1109289 0.133 0.144 4.811435e-13 CTL_TRT
## Vamp1 1.714306e-16 6.3500284 0.298 0.355 5.142918e-13 CTL_TRT
## Zcchc24 1.757459e-16 2.0071735 0.106 0.194 5.272377e-13 CTL_TRT
## Hspa1a 1.799386e-16 -0.7889905 0.295 0.340 5.398159e-13 CTL_TRT
## Met 2.027828e-16 1.0626201 0.010 0.210 6.083485e-13 CTL_TRT
## Tmem140 2.127128e-16 3.6510849 0.043 0.162 6.381385e-13 CTL_TRT
## Laptm5 2.225243e-16 -3.9415975 0.013 0.131 6.675730e-13 CTL_TRT
## Mad1l1 2.481356e-16 4.7236935 0.105 0.172 7.444069e-13 CTL_TRT
## Gas7 2.488688e-16 1.0199489 0.118 0.249 7.466064e-13 CTL_TRT
## Cabcoco1 3.070472e-16 1.8733462 0.006 0.238 9.211416e-13 CTL_TRT
## H2-Q6 3.836155e-16 1.7771533 0.007 0.141 1.150847e-12 CTL_TRT
## Dscam 4.267070e-16 2.9808414 0.212 0.180 1.280121e-12 CTL_TRT
## Aspm 4.593386e-16 2.2271796 0.002 0.119 1.378016e-12 CTL_TRT
## Zfyve1 4.833172e-16 6.4173535 0.111 0.188 1.449952e-12 CTL_TRT
## Gm13861 5.389504e-16 -0.4903493 0.005 0.128 1.616851e-12 CTL_TRT
## Lox 6.395702e-16 2.1293367 0.009 0.163 1.918711e-12 CTL_TRT
## Ppp1r14c 6.565620e-16 3.8914691 0.156 0.230 1.969686e-12 CTL_TRT
## Tmem176a 6.756185e-16 5.0968180 0.341 0.343 2.026856e-12 CTL_TRT
## Trim30a 6.818604e-16 -1.3773672 0.012 0.164 2.045581e-12 CTL_TRT
## Dock2 8.226006e-16 0.8934594 0.012 0.213 2.467802e-12 CTL_TRT
## Greb1l 8.335433e-16 4.9176967 0.061 0.154 2.500630e-12 CTL_TRT
## Tpbg 8.473664e-16 1.8692624 0.004 0.128 2.542099e-12 CTL_TRT
## Mei1 8.873020e-16 1.2926281 0.127 0.125 2.661906e-12 CTL_TRT
## Arhgdib 8.906850e-16 -0.9787901 0.009 0.131 2.672055e-12 CTL_TRT
## Nr4a2 1.083114e-15 0.5028425 0.143 0.246 3.249341e-12 CTL_TRT
## Bambi 1.163176e-15 5.9280842 0.142 0.217 3.489528e-12 CTL_TRT
## Col5a3 1.201231e-15 2.6562993 0.210 0.223 3.603692e-12 CTL_TRT
## Agl 1.225758e-15 10.9139678 0.209 0.273 3.677275e-12 CTL_TRT
## Tmem100 1.406447e-15 2.1382956 0.197 0.204 4.219341e-12 CTL_TRT
## Kdelr3 1.413663e-15 0.3920439 0.012 0.255 4.240988e-12 CTL_TRT
## Scgb1a1 1.437834e-15 1.3107534 0.034 0.220 4.313503e-12 CTL_TRT
## Kcnc2 1.693625e-15 -2.3268573 0.250 0.226 5.080875e-12 CTL_TRT
## Plcb1 1.708261e-15 1.0227914 0.251 0.266 5.124783e-12 CTL_TRT
## Stmn1 1.822923e-15 1.1279208 0.351 0.391 5.468769e-12 CTL_TRT
## Pard3 2.079394e-15 0.9226841 0.146 0.213 6.238181e-12 CTL_TRT
## Irgm1 2.150750e-15 2.4728305 0.130 0.186 6.452249e-12 CTL_TRT
## Slc39a1 2.208979e-15 1.6880737 0.074 0.218 6.626936e-12 CTL_TRT
## Slc39a8 2.571867e-15 2.6671442 0.006 0.151 7.715602e-12 CTL_TRT
## Dusp1 2.594639e-15 -1.2630186 0.344 0.333 7.783918e-12 CTL_TRT
## Oprm1 3.517581e-15 1.0385556 0.288 0.284 1.055274e-11 CTL_TRT
## Gpr158 3.565821e-15 1.2374966 0.251 0.216 1.069746e-11 CTL_TRT
## Ackr3 3.834861e-15 2.0485422 0.030 0.177 1.150458e-11 CTL_TRT
## Dpy19l3 3.954388e-15 6.6951386 0.019 0.187 1.186316e-11 CTL_TRT
## Gm11867 5.195268e-15 1.1941526 0.013 0.221 1.558580e-11 CTL_TRT
## Pid1 5.825784e-15 -0.8062863 0.060 0.139 1.747735e-11 CTL_TRT
## Fhit 6.791428e-15 0.6718440 0.216 0.231 2.037428e-11 CTL_TRT
## Slit3 6.946806e-15 1.0890681 0.023 0.151 2.084042e-11 CTL_TRT
## Gbp5 7.247302e-15 1.9991952 0.026 0.164 2.174191e-11 CTL_TRT
## Inhba 7.463856e-15 2.6805826 0.007 0.138 2.239157e-11 CTL_TRT
## Cd68 7.789142e-15 0.5993715 0.011 0.199 2.336743e-11 CTL_TRT
## Daam2 8.117787e-15 1.1840660 0.148 0.213 2.435336e-11 CTL_TRT
## Lrmda 9.932784e-15 2.9577937 0.187 0.239 2.979835e-11 CTL_TRT
## Eln 1.049522e-14 1.5553486 0.011 0.115 3.148565e-11 CTL_TRT
## 2700046A07Rik 1.117768e-14 2.2113212 0.002 0.131 3.353304e-11 CTL_TRT
## Mthfd1l 1.214141e-14 5.0183988 0.221 0.205 3.642424e-11 CTL_TRT
## Crispld1 1.276791e-14 1.1302805 0.029 0.181 3.830374e-11 CTL_TRT
## Fxyd3 1.295370e-14 0.4835438 0.147 0.231 3.886110e-11 CTL_TRT
## Kcnq5 1.320556e-14 1.8567259 0.201 0.182 3.961667e-11 CTL_TRT
## Smco3 1.480055e-14 1.7698897 0.027 0.175 4.440164e-11 CTL_TRT
## Slc1a3 1.552071e-14 0.5046083 0.117 0.171 4.656212e-11 CTL_TRT
## Brinp1 1.680607e-14 2.9977629 0.149 0.170 5.041822e-11 CTL_TRT
## Hpcal1 1.811725e-14 2.3496649 0.291 0.288 5.435175e-11 CTL_TRT
## Tnni1 1.903982e-14 2.1753180 0.007 0.130 5.711947e-11 CTL_TRT
## Plek 2.188455e-14 2.5762198 0.040 0.125 6.565366e-11 CTL_TRT
## Icam1 2.421827e-14 0.4520561 0.011 0.156 7.265481e-11 CTL_TRT
## Slc25a13 2.615202e-14 2.0105106 0.031 0.174 7.845605e-11 CTL_TRT
## Galnt18 2.657816e-14 4.1101291 0.242 0.227 7.973448e-11 CTL_TRT
## Gm42418 2.804616e-14 1.9424726 0.393 0.449 8.413849e-11 CTL_TRT
## Lrrc4 2.905152e-14 -0.5808523 0.056 0.195 8.715456e-11 CTL_TRT
## Adgrg2 2.979169e-14 1.1978046 0.180 0.185 8.937508e-11 CTL_TRT
## Col1a2 3.117576e-14 1.9439496 0.178 0.298 9.352727e-11 CTL_TRT
## Slc43a3 3.170145e-14 2.7195097 0.141 0.178 9.510436e-11 CTL_TRT
## Ntrk3 3.375296e-14 1.6728817 0.331 0.329 1.012589e-10 CTL_TRT
## Agbl4 3.738949e-14 3.1119540 0.201 0.167 1.121685e-10 CTL_TRT
## Tnik 3.972279e-14 0.8759594 0.291 0.295 1.191684e-10 CTL_TRT
## Maml2 3.977071e-14 -1.9034369 0.319 0.342 1.193121e-10 CTL_TRT
## Nptx1 4.066499e-14 1.8383065 0.221 0.229 1.219950e-10 CTL_TRT
## Bmp6 4.501202e-14 2.3463049 0.015 0.218 1.350361e-10 CTL_TRT
## Fas 5.552809e-14 1.9288994 0.036 0.212 1.665843e-10 CTL_TRT
## D430041D05Rik 5.811535e-14 -0.3311625 0.060 0.122 1.743461e-10 CTL_TRT
## Erbb3 6.618540e-14 3.2465891 0.127 0.194 1.985562e-10 CTL_TRT
## Trim12a 6.830207e-14 1.4755473 0.020 0.174 2.049062e-10 CTL_TRT
## C130074G19Rik 7.130499e-14 -1.5139173 0.017 0.140 2.139150e-10 CTL_TRT
## Sostdc1 7.137223e-14 1.9766669 0.240 0.250 2.141167e-10 CTL_TRT
## Lrrtm3 7.968483e-14 3.2937482 0.210 0.207 2.390545e-10 CTL_TRT
## Map1b 8.658710e-14 1.6429811 0.427 0.478 2.597613e-10 CTL_TRT
## Cdk6 8.730035e-14 -0.3734582 0.098 0.174 2.619011e-10 CTL_TRT
## B130024G19Rik 9.366223e-14 1.2259580 0.010 0.236 2.809867e-10 CTL_TRT
## Arhgef40 1.015615e-13 5.9952374 0.157 0.234 3.046845e-10 CTL_TRT
## Aqp4 1.096793e-13 -0.4151080 0.073 0.148 3.290378e-10 CTL_TRT
## Gm16638 1.129660e-13 3.3402790 0.056 0.183 3.388981e-10 CTL_TRT
## Txnip 1.159262e-13 0.8399032 0.113 0.223 3.477785e-10 CTL_TRT
## Pdgfrb 1.188810e-13 5.8961154 0.087 0.205 3.566431e-10 CTL_TRT
## Enah 1.214175e-13 1.4191445 0.325 0.293 3.642524e-10 CTL_TRT
## Pmepa1 1.331987e-13 2.7144306 0.305 0.287 3.995961e-10 CTL_TRT
## Tcf4 1.554851e-13 0.5815452 0.236 0.318 4.664553e-10 CTL_TRT
## Ppara 1.584871e-13 3.3565905 0.020 0.206 4.754613e-10 CTL_TRT
## Gabrg1 1.739039e-13 3.8026653 0.063 0.177 5.217116e-10 CTL_TRT
## Cdh18 2.280279e-13 0.7438799 0.170 0.141 6.840838e-10 CTL_TRT
## Epha7 2.350046e-13 1.2150460 0.085 0.174 7.050139e-10 CTL_TRT
## Rimklb 2.483605e-13 2.2555237 0.076 0.164 7.450816e-10 CTL_TRT
## Tcim 2.484751e-13 1.8563465 0.041 0.200 7.454253e-10 CTL_TRT
## Hsd17b11 2.696422e-13 2.2277673 0.173 0.264 8.089266e-10 CTL_TRT
## Nefl 2.824224e-13 5.8064217 0.385 0.448 8.472672e-10 CTL_TRT
## Otud7a 2.974243e-13 1.9035537 0.256 0.224 8.922729e-10 CTL_TRT
## Arap2 3.062743e-13 5.0325744 0.162 0.195 9.188230e-10 CTL_TRT
## Slpi 3.174848e-13 2.1889220 0.027 0.192 9.524543e-10 CTL_TRT
## Adamtsl1 3.391940e-13 0.7653106 0.015 0.232 1.017582e-09 CTL_TRT
## Rasd1 3.785396e-13 -0.5790508 0.034 0.136 1.135619e-09 CTL_TRT
## G0s2 3.851101e-13 2.4157238 0.175 0.224 1.155330e-09 CTL_TRT
## Ugt8a 4.024832e-13 2.7771569 0.081 0.176 1.207450e-09 CTL_TRT
## Rasgrf1 4.051294e-13 0.2914775 0.065 0.126 1.215388e-09 CTL_TRT
## Fam172a 4.718063e-13 9.3710004 0.264 0.283 1.415419e-09 CTL_TRT
## Iigp1 5.203976e-13 0.5779361 0.075 0.148 1.561193e-09 CTL_TRT
## Itgb4 5.609170e-13 0.7923693 0.023 0.247 1.682751e-09 CTL_TRT
## Gucd1 5.939570e-13 0.7139720 0.179 0.180 1.781871e-09 CTL_TRT
## Has1 6.005547e-13 2.1986801 0.006 0.128 1.801664e-09 CTL_TRT
## Apoe 6.134464e-13 1.4891593 0.386 0.341 1.840339e-09 CTL_TRT
## Gm36279 6.268559e-13 3.5324678 0.004 0.142 1.880568e-09 CTL_TRT
## Flvcr2 6.395085e-13 3.3799738 0.007 0.214 1.918525e-09 CTL_TRT
## Myof 6.721753e-13 3.5003426 0.006 0.137 2.016526e-09 CTL_TRT
## Itgb3 6.928621e-13 -1.8761894 0.055 0.220 2.078586e-09 CTL_TRT
## Mov10l1 7.163736e-13 3.8034241 0.037 0.101 2.149121e-09 CTL_TRT
## 1700111E14Rik 7.937357e-13 3.4440279 0.073 0.162 2.381207e-09 CTL_TRT
## Ndufa4l2 8.308113e-13 -1.7081276 0.006 0.100 2.492434e-09 CTL_TRT
## Pcdh10 8.698989e-13 -0.8574040 0.241 0.282 2.609697e-09 CTL_TRT
## Metrnl 9.062062e-13 -0.5567421 0.084 0.180 2.718619e-09 CTL_TRT
## S100a10 9.497678e-13 0.3544506 0.442 0.481 2.849303e-09 CTL_TRT
## Itgav 9.711469e-13 -1.7442632 0.251 0.237 2.913441e-09 CTL_TRT
## Usp6nl 1.049571e-12 1.1469516 0.228 0.237 3.148712e-09 CTL_TRT
## AI593442 1.269723e-12 0.4783377 0.245 0.222 3.809168e-09 CTL_TRT
## Suclg2 1.314983e-12 1.7265887 0.071 0.206 3.944950e-09 CTL_TRT
## Focad 1.517851e-12 4.0828673 0.132 0.143 4.553552e-09 CTL_TRT
## Fut8 1.519522e-12 -4.0736334 0.220 0.243 4.558566e-09 CTL_TRT
## Stac 1.542561e-12 1.9561954 0.261 0.255 4.627683e-09 CTL_TRT
## Npy2r 1.546786e-12 1.6351951 0.107 0.140 4.640359e-09 CTL_TRT
## Grip1os2 1.789558e-12 6.0602201 0.007 0.154 5.368675e-09 CTL_TRT
## Ifitm1 1.805655e-12 2.6063537 0.037 0.127 5.416965e-09 CTL_TRT
## A830018L16Rik 1.826705e-12 3.4679355 0.265 0.240 5.480115e-09 CTL_TRT
## Zswim6 1.838491e-12 3.9990463 0.349 0.364 5.515474e-09 CTL_TRT
## Tmem255a 1.852217e-12 1.0559492 0.315 0.301 5.556652e-09 CTL_TRT
## Pcdh17 1.934245e-12 -2.6500529 0.206 0.267 5.802736e-09 CTL_TRT
## Kcnmb1 2.007561e-12 0.2532503 0.193 0.212 6.022684e-09 CTL_TRT
## Tafa2 2.546894e-12 -1.0139187 0.174 0.148 7.640683e-09 CTL_TRT
## Emp2 2.564355e-12 3.9713751 0.149 0.245 7.693066e-09 CTL_TRT
## Mylip 2.576464e-12 -0.7121662 0.055 0.258 7.729393e-09 CTL_TRT
## Foxo1 3.452702e-12 3.4356174 0.085 0.178 1.035811e-08 CTL_TRT
## Fap 3.723303e-12 2.0306812 0.013 0.174 1.116991e-08 CTL_TRT
## Pcsk2 4.181951e-12 0.3175902 0.373 0.323 1.254585e-08 CTL_TRT
## Emp1 5.124632e-12 1.0792852 0.035 0.158 1.537389e-08 CTL_TRT
## Cntn4 5.520642e-12 3.2348747 0.082 0.115 1.656193e-08 CTL_TRT
## Pxdc1 6.183478e-12 2.0466095 0.046 0.216 1.855043e-08 CTL_TRT
## Rbms2 6.256201e-12 5.8446777 0.073 0.204 1.876860e-08 CTL_TRT
## Rgs5 6.424204e-12 1.1295070 0.163 0.156 1.927261e-08 CTL_TRT
## Nbea 7.127149e-12 5.2411472 0.229 0.237 2.138145e-08 CTL_TRT
## Twist1 8.442226e-12 2.6665156 0.007 0.158 2.532668e-08 CTL_TRT
## Ly6c1 8.889831e-12 1.5869233 0.032 0.104 2.666949e-08 CTL_TRT
## Adcyap1 9.885618e-12 1.2898263 0.237 0.232 2.965686e-08 CTL_TRT
## Fam155a 1.078173e-11 0.7596612 0.207 0.172 3.234518e-08 CTL_TRT
## Scg3 1.097818e-11 -2.4962912 0.440 0.377 3.293454e-08 CTL_TRT
## Crip1 1.177037e-11 0.8711598 0.313 0.361 3.531112e-08 CTL_TRT
## Mia 1.189273e-11 2.8371217 0.058 0.195 3.567818e-08 CTL_TRT
## Pag1 1.220653e-11 0.2806110 0.193 0.206 3.661958e-08 CTL_TRT
## Ptprd 1.239968e-11 2.1618677 0.237 0.211 3.719903e-08 CTL_TRT
## Htr4 1.270879e-11 -0.9030727 0.124 0.116 3.812638e-08 CTL_TRT
## Jak1 1.479807e-11 2.4308007 0.323 0.346 4.439421e-08 CTL_TRT
## Tgtp1 1.544834e-11 -0.5130130 0.001 0.167 4.634501e-08 CTL_TRT
## Gm10785 1.556597e-11 2.4623968 0.024 0.211 4.669791e-08 CTL_TRT
## Baiap2l1 1.562755e-11 0.5253482 0.074 0.165 4.688266e-08 CTL_TRT
## Pcdh9 1.618850e-11 0.3875445 0.299 0.298 4.856549e-08 CTL_TRT
## Map2 1.883286e-11 2.8476090 0.280 0.282 5.649859e-08 CTL_TRT
## Gjc3 1.905582e-11 -0.4778332 0.087 0.232 5.716745e-08 CTL_TRT
## Pde11a 1.971911e-11 1.8670112 0.226 0.214 5.915733e-08 CTL_TRT
## E130114P18Rik 2.025910e-11 2.2680281 0.053 0.206 6.077731e-08 CTL_TRT
## Epha6 2.071390e-11 1.5874910 0.120 0.105 6.214169e-08 CTL_TRT
## Pxn 2.080358e-11 1.1382816 0.085 0.223 6.241074e-08 CTL_TRT
## Chrm2 2.362218e-11 3.6562324 0.062 0.132 7.086654e-08 CTL_TRT
## Casz1 2.377164e-11 0.8965142 0.238 0.188 7.131492e-08 CTL_TRT
## Syne1 2.419497e-11 3.3908364 0.249 0.258 7.258491e-08 CTL_TRT
## Stat1 2.443240e-11 -3.4736301 0.173 0.245 7.329721e-08 CTL_TRT
## Slc7a11 2.467837e-11 1.5605346 0.008 0.180 7.403510e-08 CTL_TRT
## Atp1b2 2.515001e-11 1.8470370 0.178 0.207 7.545004e-08 CTL_TRT
## Gm20713 2.867945e-11 2.4057566 0.009 0.109 8.603834e-08 CTL_TRT
## B020031H02Rik 2.944372e-11 1.8516352 0.012 0.184 8.833116e-08 CTL_TRT
## Cyth4 3.154486e-11 2.4292220 0.006 0.214 9.463459e-08 CTL_TRT
## Pdpn 3.257365e-11 2.6064967 0.124 0.188 9.772094e-08 CTL_TRT
## Kctd1 3.494469e-11 -3.5150539 0.156 0.247 1.048341e-07 CTL_TRT
## Foxc1 3.826253e-11 1.6255037 0.012 0.102 1.147876e-07 CTL_TRT
## Rpl39 3.874866e-11 8.0877770 0.477 0.519 1.162460e-07 CTL_TRT
## Arhgef3 4.549005e-11 2.5529193 0.089 0.147 1.364701e-07 CTL_TRT
## Sox6 4.777531e-11 3.8563993 0.166 0.251 1.433259e-07 CTL_TRT
## Comp 4.985398e-11 -0.4731352 0.014 0.144 1.495619e-07 CTL_TRT
## Dnajb1 4.991481e-11 2.5660113 0.366 0.353 1.497444e-07 CTL_TRT
## Kcnk2 5.302721e-11 2.4433188 0.194 0.228 1.590816e-07 CTL_TRT
## Cxcl2 5.596601e-11 3.0693720 0.016 0.105 1.678980e-07 CTL_TRT
## Insyn2b 5.721092e-11 3.1287896 0.024 0.183 1.716327e-07 CTL_TRT
## H2-Q4 5.725203e-11 3.6846525 0.067 0.206 1.717561e-07 CTL_TRT
## Tnfsf9 6.187889e-11 2.5963026 0.016 0.222 1.856367e-07 CTL_TRT
## Ctnnd2 6.992001e-11 0.7686067 0.413 0.349 2.097600e-07 CTL_TRT
## Gm44691 8.708887e-11 1.8966165 0.007 0.221 2.612666e-07 CTL_TRT
## Enpp1 9.758275e-11 2.8277152 0.053 0.188 2.927483e-07 CTL_TRT
## Rlbp1 1.001466e-10 0.5770708 0.036 0.182 3.004399e-07 CTL_TRT
## Mbp 1.030655e-10 -1.1626600 0.350 0.374 3.091965e-07 CTL_TRT
## Col24a1 1.059894e-10 1.3634086 0.073 0.101 3.179683e-07 CTL_TRT
## Dlc1 1.074553e-10 -5.6560488 0.292 0.340 3.223659e-07 CTL_TRT
## Kansl1l 1.075959e-10 -1.9368260 0.173 0.252 3.227878e-07 CTL_TRT
## Tgfb2 1.099455e-10 3.3461056 0.067 0.219 3.298365e-07 CTL_TRT
## Scd2 1.250450e-10 2.2234109 0.392 0.339 3.751351e-07 CTL_TRT
## Cdkn2c 1.308540e-10 1.7970595 0.032 0.214 3.925621e-07 CTL_TRT
## Aqp1 1.373018e-10 0.9786669 0.333 0.298 4.119054e-07 CTL_TRT
## Fmo2 1.670628e-10 -0.6214899 0.010 0.139 5.011884e-07 CTL_TRT
## Rnd3 1.745786e-10 1.1031297 0.159 0.246 5.237359e-07 CTL_TRT
## Col11a1 1.807620e-10 2.4770581 0.098 0.166 5.422860e-07 CTL_TRT
## Heatr5a 1.937461e-10 2.0086238 0.224 0.224 5.812384e-07 CTL_TRT
## Tead1 2.056263e-10 1.9025983 0.258 0.320 6.168789e-07 CTL_TRT
## Golim4 2.104000e-10 2.6339350 0.166 0.190 6.311999e-07 CTL_TRT
## Ubc 2.181878e-10 1.5039537 0.407 0.452 6.545635e-07 CTL_TRT
## Ppp1r1a 2.261783e-10 -1.2923125 0.279 0.249 6.785348e-07 CTL_TRT
## Apobec1 2.407999e-10 1.4054990 0.035 0.206 7.223998e-07 CTL_TRT
## Mcc 2.427919e-10 0.9968642 0.176 0.168 7.283758e-07 CTL_TRT
## Lamc1 2.476440e-10 4.0730833 0.130 0.225 7.429320e-07 CTL_TRT
## 4930517O19Rik 2.739958e-10 2.0948428 0.018 0.107 8.219874e-07 CTL_TRT
## Higd1b 2.780736e-10 2.0131477 0.005 0.111 8.342207e-07 CTL_TRT
## Uba7 2.917515e-10 1.3448880 0.051 0.219 8.752544e-07 CTL_TRT
## Ccn2 2.943814e-10 -0.7148788 0.008 0.162 8.831441e-07 CTL_TRT
## Ptafr 3.032486e-10 0.6068710 0.022 0.129 9.097457e-07 CTL_TRT
## Hes1 3.150289e-10 0.9290851 0.266 0.317 9.450866e-07 CTL_TRT
## Spi1 3.168260e-10 -2.2521484 0.007 0.132 9.504780e-07 CTL_TRT
## Nbl1 3.198293e-10 -1.7832796 0.299 0.271 9.594879e-07 CTL_TRT
## Gm20642 3.218156e-10 0.8512399 0.141 0.158 9.654467e-07 CTL_TRT
## Cdh19 3.515636e-10 1.8220347 0.247 0.293 1.054691e-06 CTL_TRT
## Metrn 3.628384e-10 2.3073289 0.143 0.183 1.088515e-06 CTL_TRT
## Ntrk2 3.708447e-10 1.8633378 0.334 0.303 1.112534e-06 CTL_TRT
## Mxra8 3.712082e-10 -1.6632343 0.051 0.171 1.113625e-06 CTL_TRT
## C130071C03Rik 3.809946e-10 0.8414700 0.136 0.196 1.142984e-06 CTL_TRT
## Iqgap1 3.831177e-10 6.0244697 0.230 0.305 1.149353e-06 CTL_TRT
## Gbp4 4.168800e-10 2.6979867 0.005 0.125 1.250640e-06 CTL_TRT
## Gng11 4.239392e-10 0.8468544 0.123 0.244 1.271818e-06 CTL_TRT
## Pllp 4.268923e-10 1.5474283 0.062 0.193 1.280677e-06 CTL_TRT
## Srpx 4.403911e-10 -1.0171916 0.039 0.190 1.321173e-06 CTL_TRT
## Gsn 4.601249e-10 -0.4976784 0.323 0.333 1.380375e-06 CTL_TRT
## Gabrb3 4.879337e-10 6.5621063 0.279 0.247 1.463801e-06 CTL_TRT
## Fam129a 4.906366e-10 2.9261752 0.136 0.210 1.471910e-06 CTL_TRT
## Zfp24 4.920583e-10 1.6390051 0.214 0.248 1.476175e-06 CTL_TRT
## Frem2 5.507361e-10 1.4975281 0.034 0.134 1.652208e-06 CTL_TRT
## Dusp16 5.690414e-10 3.7747885 0.108 0.271 1.707124e-06 CTL_TRT
## Arhgdig 5.921117e-10 3.1626657 0.393 0.367 1.776335e-06 CTL_TRT
## Shox2 5.934932e-10 1.5306253 0.062 0.203 1.780479e-06 CTL_TRT
## S100a6 6.092810e-10 2.0705499 0.386 0.433 1.827843e-06 CTL_TRT
## Gm37240 6.343057e-10 1.3111231 0.228 0.250 1.902917e-06 CTL_TRT
## Tubb6 6.606771e-10 1.5801183 0.019 0.200 1.982031e-06 CTL_TRT
## Adamts5 7.647014e-10 2.3810483 0.269 0.263 2.294104e-06 CTL_TRT
## Gstk1 7.672527e-10 0.6631972 0.048 0.157 2.301758e-06 CTL_TRT
## Atp1b1 7.783503e-10 1.0064806 0.336 0.371 2.335051e-06 CTL_TRT
## Lamb2 7.947329e-10 1.8215699 0.058 0.211 2.384199e-06 CTL_TRT
## Igfbp7 8.273307e-10 -3.6470724 0.059 0.158 2.481992e-06 CTL_TRT
## Man1a 8.775585e-10 1.5725645 0.069 0.155 2.632676e-06 CTL_TRT
## Dcc 9.287334e-10 1.8897768 0.064 0.118 2.786200e-06 CTL_TRT
## Zbtb25 9.503329e-10 6.0965154 0.047 0.179 2.850999e-06 CTL_TRT
## Foxd3 9.776679e-10 2.8171360 0.102 0.210 2.933004e-06 CTL_TRT
## Penk 9.921344e-10 2.2444490 0.011 0.154 2.976403e-06 CTL_TRT
## Tbxas1 9.970972e-10 2.4968551 0.009 0.200 2.991292e-06 CTL_TRT
## Sgcz 1.083670e-09 1.5258801 0.194 0.149 3.251011e-06 CTL_TRT
## Sult5a1 1.155329e-09 1.2956453 0.002 0.129 3.465987e-06 CTL_TRT
## Ptprg 1.279257e-09 -0.6389212 0.316 0.308 3.837771e-06 CTL_TRT
## Rdh5 1.545151e-09 -1.0467514 0.159 0.192 4.635454e-06 CTL_TRT
## Myo10 1.555099e-09 5.0753343 0.221 0.255 4.665297e-06 CTL_TRT
## Numb 1.592707e-09 2.1923345 0.289 0.288 4.778120e-06 CTL_TRT
## Lef1 1.645253e-09 2.1562028 0.032 0.137 4.935760e-06 CTL_TRT
## Schip1 1.654983e-09 0.9995911 0.305 0.290 4.964950e-06 CTL_TRT
## Pon2 1.828347e-09 1.3541802 0.110 0.183 5.485042e-06 CTL_TRT
## Ttyh1 2.013522e-09 2.0880345 0.215 0.226 6.040565e-06 CTL_TRT
## Pcsk1 2.059067e-09 0.3901859 0.180 0.184 6.177201e-06 CTL_TRT
## Olfr56 2.094002e-09 1.7119687 0.004 0.130 6.282007e-06 CTL_TRT
## Tacc1 2.190455e-09 8.4922788 0.279 0.319 6.571364e-06 CTL_TRT
## Clu 2.219842e-09 1.1817678 0.359 0.372 6.659527e-06 CTL_TRT
## Mmd2 2.266711e-09 0.3844711 0.266 0.235 6.800132e-06 CTL_TRT
## Trpv1 2.299770e-09 0.3078144 0.237 0.252 6.899311e-06 CTL_TRT
## Ppp1r15a 2.385935e-09 5.0334949 0.278 0.311 7.157805e-06 CTL_TRT
## Ptn 2.435107e-09 1.5581274 0.348 0.327 7.305321e-06 CTL_TRT
## Ryr3 2.589402e-09 2.5527791 0.094 0.135 7.768207e-06 CTL_TRT
## Slitrk2 2.682258e-09 -0.8925428 0.073 0.159 8.046773e-06 CTL_TRT
## Scarb1 2.762582e-09 3.4055233 0.056 0.179 8.287747e-06 CTL_TRT
## Gm46367 3.015214e-09 2.4417342 0.060 0.126 9.045643e-06 CTL_TRT
## Rasgrp1 3.422408e-09 -2.1268167 0.237 0.211 1.026722e-05 CTL_TRT
## Rps8 3.691416e-09 -0.2598524 0.444 0.495 1.107425e-05 CTL_TRT
## Mir100hg 3.781418e-09 2.5901012 0.300 0.341 1.134425e-05 CTL_TRT
## Utrn 4.099335e-09 8.4284561 0.421 0.438 1.229800e-05 CTL_TRT
## Setbp1 4.607332e-09 1.0570864 0.186 0.227 1.382200e-05 CTL_TRT
## Fth1 4.895083e-09 3.3656706 0.453 0.491 1.468525e-05 CTL_TRT
## Catsperz 4.904321e-09 2.5893655 0.099 0.185 1.471296e-05 CTL_TRT
## Epb41 5.176388e-09 -2.1892144 0.263 0.233 1.552916e-05 CTL_TRT
## Pld5 5.334352e-09 -3.7838185 0.273 0.226 1.600306e-05 CTL_TRT
## Dennd2a 5.383555e-09 5.0279987 0.088 0.189 1.615066e-05 CTL_TRT
## mt-Nd3 5.399697e-09 0.5607964 0.419 0.461 1.619909e-05 CTL_TRT
## Ly6e 5.631394e-09 0.6177819 0.051 0.141 1.689418e-05 CTL_TRT
## Sntb2 5.767413e-09 4.8961668 0.205 0.281 1.730224e-05 CTL_TRT
## Psph 5.813315e-09 0.5871096 0.150 0.233 1.743995e-05 CTL_TRT
## Tgfbr2 6.184550e-09 -1.6212679 0.069 0.218 1.855365e-05 CTL_TRT
## AW112010 6.508420e-09 -0.5702351 0.011 0.159 1.952526e-05 CTL_TRT
## Eml6 7.320660e-09 4.5755093 0.191 0.189 2.196198e-05 CTL_TRT
## March3 8.489263e-09 0.2793677 0.125 0.197 2.546779e-05 CTL_TRT
## Gm13629 9.783754e-09 2.5956112 0.028 0.137 2.935126e-05 CTL_TRT
## Csrp2 1.061296e-08 2.7120471 0.176 0.213 3.183889e-05 CTL_TRT
## Kcnc1 1.066593e-08 2.5340317 0.151 0.213 3.199778e-05 CTL_TRT
## Ptgds 1.186497e-08 0.9748865 0.076 0.199 3.559491e-05 CTL_TRT
## Tmem56 1.254351e-08 -2.3316805 0.289 0.251 3.763054e-05 CTL_TRT
## Stim1 1.274918e-08 8.1926042 0.197 0.255 3.824755e-05 CTL_TRT
## Alas2 1.368012e-08 2.5330184 0.003 0.105 4.104035e-05 CTL_TRT
## Mt3 1.400948e-08 3.9143805 0.446 0.486 4.202844e-05 CTL_TRT
## Gm8113 1.597881e-08 2.1111353 0.002 0.123 4.793642e-05 CTL_TRT
## Selenop 1.611786e-08 1.9303468 0.336 0.325 4.835359e-05 CTL_TRT
## Ptprj 1.647717e-08 1.1866904 0.111 0.205 4.943152e-05 CTL_TRT
## Gm29811 1.654528e-08 1.7866851 0.003 0.150 4.963585e-05 CTL_TRT
## Ccl12 1.714971e-08 1.5155733 0.009 0.107 5.144914e-05 CTL_TRT
## Chd7 1.773392e-08 3.2601819 0.054 0.238 5.320177e-05 CTL_TRT
## Gpm6b 1.833350e-08 1.7506130 0.356 0.322 5.500049e-05 CTL_TRT
## Adamts1 1.881604e-08 0.8181787 0.214 0.280 5.644813e-05 CTL_TRT
## Col25a1 1.893690e-08 3.1457860 0.069 0.135 5.681069e-05 CTL_TRT
## Tst 1.963719e-08 0.6254557 0.075 0.179 5.891158e-05 CTL_TRT
## Lingo2 2.208895e-08 0.7486218 0.198 0.161 6.626686e-05 CTL_TRT
## Cyba 2.333859e-08 1.3572779 0.041 0.204 7.001576e-05 CTL_TRT
## Kcnma1 2.365370e-08 0.3090936 0.287 0.250 7.096110e-05 CTL_TRT
## Pnoc 2.378372e-08 2.3139398 0.010 0.110 7.135116e-05 CTL_TRT
## Lxn 2.403216e-08 0.8084865 0.326 0.341 7.209648e-05 CTL_TRT
## Shc4 2.518523e-08 2.4432847 0.090 0.183 7.555569e-05 CTL_TRT
## Ngfr 2.616190e-08 1.2244169 0.284 0.288 7.848569e-05 CTL_TRT
## Cntnap5a 2.666486e-08 1.5870767 0.193 0.174 7.999458e-05 CTL_TRT
## Trpa1 2.776591e-08 2.7588329 0.137 0.167 8.329772e-05 CTL_TRT
## Zbp1 2.832282e-08 2.7733386 0.005 0.192 8.496845e-05 CTL_TRT
## Shroom1 2.934520e-08 1.7496071 0.002 0.103 8.803560e-05 CTL_TRT
## 1700016F12Rik 3.187876e-08 2.0107261 0.002 0.115 9.563627e-05 CTL_TRT
## Casp4 3.296646e-08 2.6438846 0.097 0.202 9.889939e-05 CTL_TRT
## Tmem229b 3.411175e-08 4.0418806 0.204 0.224 1.023352e-04 CTL_TRT
## Ntm 3.683626e-08 2.1251316 0.101 0.154 1.105088e-04 CTL_TRT
## Pex11a 3.848076e-08 1.8712692 0.039 0.146 1.154423e-04 CTL_TRT
## 4930469K13Rik 3.850146e-08 1.6400738 0.034 0.173 1.155044e-04 CTL_TRT
## Fbn1 3.882699e-08 1.2150273 0.034 0.154 1.164810e-04 CTL_TRT
## Bhlhe40 3.907837e-08 4.8061490 0.276 0.275 1.172351e-04 CTL_TRT
## Lbhd2 3.953132e-08 2.3739932 0.014 0.222 1.185939e-04 CTL_TRT
## Ppp3ca 4.009694e-08 0.3073970 0.409 0.435 1.202908e-04 CTL_TRT
## Matn2 4.041476e-08 -0.8791880 0.232 0.273 1.212443e-04 CTL_TRT
## Gpc5 4.173599e-08 1.3064736 0.218 0.176 1.252080e-04 CTL_TRT
## Peli2 4.177204e-08 1.7638978 0.181 0.273 1.253161e-04 CTL_TRT
## Nrp1 4.349361e-08 3.9305849 0.197 0.204 1.304808e-04 CTL_TRT
## Nr2f1 5.560968e-08 2.1295172 0.132 0.238 1.668291e-04 CTL_TRT
## Zbtb9 5.754913e-08 4.3877359 0.047 0.169 1.726474e-04 CTL_TRT
## Nol4 5.968613e-08 1.4025745 0.209 0.182 1.790584e-04 CTL_TRT
## Itga5 6.619460e-08 2.1977755 0.007 0.143 1.985838e-04 CTL_TRT
## Klf2 6.750593e-08 -0.4100675 0.147 0.243 2.025178e-04 CTL_TRT
## Gria4 6.979295e-08 2.6496192 0.268 0.278 2.093789e-04 CTL_TRT
## Cobll1 7.128112e-08 -1.0084123 0.103 0.188 2.138434e-04 CTL_TRT
## Vav3 7.163698e-08 -0.6255517 0.190 0.151 2.149109e-04 CTL_TRT
## Tgfb1 7.570833e-08 2.2552847 0.069 0.155 2.271250e-04 CTL_TRT
## Limd1 8.475812e-08 5.4578068 0.100 0.200 2.542744e-04 CTL_TRT
## Klf4 8.557835e-08 1.7177933 0.191 0.317 2.567351e-04 CTL_TRT
## Gm20754 8.732952e-08 1.0264883 0.030 0.120 2.619886e-04 CTL_TRT
## Ntn1 9.416782e-08 4.0755263 0.009 0.178 2.825034e-04 CTL_TRT
## Fbn2 9.756105e-08 1.9643805 0.016 0.208 2.926832e-04 CTL_TRT
## Crlf1 1.035939e-07 2.3864041 0.062 0.152 3.107818e-04 CTL_TRT
## Adamts9 1.110703e-07 0.5451489 0.114 0.184 3.332108e-04 CTL_TRT
## Dbi 1.114933e-07 1.7463620 0.363 0.337 3.344799e-04 CTL_TRT
## Ralyl 1.309451e-07 2.7255441 0.290 0.272 3.928354e-04 CTL_TRT
## Marcksl1 1.401797e-07 -0.3664854 0.177 0.229 4.205392e-04 CTL_TRT
## Tnxb 1.479490e-07 1.6140267 0.060 0.199 4.438469e-04 CTL_TRT
## Xist 1.486538e-07 0.4745735 0.391 0.449 4.459613e-04 CTL_TRT
## Ier5 1.522164e-07 2.0373223 0.059 0.192 4.566493e-04 CTL_TRT
## Hist1h2ap 1.627145e-07 -2.0415878 0.033 0.165 4.881435e-04 CTL_TRT
## Fzd2 1.639006e-07 2.4610966 0.041 0.159 4.917017e-04 CTL_TRT
## Yap1 1.722014e-07 1.5405987 0.068 0.237 5.166042e-04 CTL_TRT
## A230057D06Rik 1.902805e-07 2.0014427 0.243 0.194 5.708414e-04 CTL_TRT
## Tmem47 1.915537e-07 -1.3964471 0.305 0.279 5.746610e-04 CTL_TRT
## Pard3b 1.995714e-07 6.2396889 0.202 0.303 5.987142e-04 CTL_TRT
## Fam107a 2.020178e-07 0.9344303 0.036 0.163 6.060534e-04 CTL_TRT
## Kctd12 2.277532e-07 0.4155264 0.041 0.205 6.832595e-04 CTL_TRT
## Dner 2.577806e-07 -0.7038036 0.330 0.298 7.733418e-04 CTL_TRT
## Thrsp 2.582688e-07 1.2330790 0.042 0.221 7.748064e-04 CTL_TRT
## Erbb4 2.767710e-07 1.9192877 0.023 0.152 8.303129e-04 CTL_TRT
## Adarb2 2.820256e-07 2.7780764 0.039 0.143 8.460767e-04 CTL_TRT
## Arl15 2.908939e-07 -3.8302067 0.283 0.282 8.726818e-04 CTL_TRT
## Twsg1 2.913533e-07 5.0029372 0.067 0.178 8.740598e-04 CTL_TRT
## Tuba1a 3.163468e-07 0.4554820 0.432 0.470 9.490404e-04 CTL_TRT
## Lgi1 3.294171e-07 0.6519779 0.273 0.238 9.882512e-04 CTL_TRT
## Plxna4 3.356481e-07 0.9997469 0.231 0.233 1.006944e-03 CTL_TRT
## Snap25 3.362488e-07 2.4189779 0.381 0.415 1.008746e-03 CTL_TRT
## Tnc 3.594859e-07 2.2223212 0.016 0.151 1.078458e-03 CTL_TRT
## BC067074 3.712746e-07 2.5076953 0.023 0.185 1.113824e-03 CTL_TRT
## Chst9 3.776031e-07 1.6498564 0.039 0.102 1.132809e-03 CTL_TRT
## Pdgfc 3.824882e-07 1.3128195 0.040 0.218 1.147465e-03 CTL_TRT
## Fcer1g 3.843859e-07 -0.5319055 0.034 0.100 1.153158e-03 CTL_TRT
## Cplx1 4.112223e-07 1.0743359 0.390 0.401 1.233667e-03 CTL_TRT
## Cd38 4.439758e-07 1.7593512 0.006 0.179 1.331927e-03 CTL_TRT
## Cadm1 4.529792e-07 0.9696461 0.365 0.322 1.358938e-03 CTL_TRT
## Gas6 4.569943e-07 2.3682717 0.228 0.231 1.370983e-03 CTL_TRT
## Neat1 4.710401e-07 -2.2580517 0.192 0.272 1.413120e-03 CTL_TRT
## Osbpl6 5.000362e-07 2.9579814 0.251 0.220 1.500109e-03 CTL_TRT
## Sema3g 5.272872e-07 0.8543183 0.036 0.206 1.581862e-03 CTL_TRT
## Stat4 5.622422e-07 2.0710702 0.003 0.104 1.686726e-03 CTL_TRT
## Tmem233 5.842842e-07 2.4736144 0.336 0.369 1.752853e-03 CTL_TRT
## 3110021N24Rik 6.165892e-07 1.1831095 0.130 0.192 1.849768e-03 CTL_TRT
## Vamp5 6.174847e-07 -0.8110935 0.144 0.211 1.852454e-03 CTL_TRT
## Fbxo7 6.624676e-07 -3.1630904 0.143 0.209 1.987403e-03 CTL_TRT
## Cpeb3 6.683593e-07 0.7711505 0.273 0.247 2.005078e-03 CTL_TRT
## Fli1 6.906858e-07 1.0019048 0.059 0.140 2.072057e-03 CTL_TRT
## Atp11a 7.167364e-07 1.6983103 0.312 0.300 2.150209e-03 CTL_TRT
## Cmss1 7.726708e-07 0.3210295 0.367 0.416 2.318013e-03 CTL_TRT
## Ptprz1 7.783995e-07 1.0438214 0.310 0.283 2.335198e-03 CTL_TRT
## Adamts18 8.015056e-07 1.6967259 0.015 0.200 2.404517e-03 CTL_TRT
## Col15a1 8.138809e-07 -1.0874797 0.047 0.207 2.441643e-03 CTL_TRT
## Cd200 8.343643e-07 -1.3219263 0.306 0.289 2.503093e-03 CTL_TRT
## Ctsk 8.391858e-07 2.4127803 0.051 0.165 2.517557e-03 CTL_TRT
## Gulp1 8.405683e-07 3.1996680 0.135 0.238 2.521705e-03 CTL_TRT
## Astn2 8.563003e-07 3.6181511 0.304 0.282 2.568901e-03 CTL_TRT
## 2900052N01Rik 8.589407e-07 0.4802815 0.163 0.180 2.576822e-03 CTL_TRT
## Itih5 8.832455e-07 -0.2905333 0.155 0.277 2.649736e-03 CTL_TRT
## Sox5 8.983641e-07 0.9984158 0.057 0.198 2.695092e-03 CTL_TRT
## Fxyd2 9.349175e-07 1.2638361 0.331 0.337 2.804752e-03 CTL_TRT
## C130021I20Rik 9.365106e-07 3.2504016 0.005 0.202 2.809532e-03 CTL_TRT
## Tram2 9.643404e-07 2.4048956 0.014 0.249 2.893021e-03 CTL_TRT
## Cstdc2 9.773825e-07 2.1145475 0.002 0.133 2.932147e-03 CTL_TRT
## Tubgcp5 1.045290e-06 9.9353253 0.143 0.219 3.135871e-03 CTL_TRT
## Cep85l 1.051940e-06 -1.2242385 0.264 0.269 3.155821e-03 CTL_TRT
## Magi2 1.108407e-06 0.7135495 0.317 0.318 3.325221e-03 CTL_TRT
## mt-Nd4l 1.160286e-06 2.5397257 0.435 0.473 3.480858e-03 CTL_TRT
## Bcas1 1.187490e-06 0.5127828 0.057 0.211 3.562469e-03 CTL_TRT
## Luzp2 1.310460e-06 3.4969678 0.378 0.326 3.931381e-03 CTL_TRT
## Gfra1 1.315747e-06 1.9835561 0.248 0.252 3.947241e-03 CTL_TRT
## Ctsh 1.338125e-06 -0.3627406 0.010 0.147 4.014375e-03 CTL_TRT
## Rgs10 1.417268e-06 1.0259877 0.320 0.333 4.251805e-03 CTL_TRT
## Asap1 1.434168e-06 0.9308270 0.387 0.358 4.302504e-03 CTL_TRT
## Tm4sf1 1.472896e-06 1.1060739 0.052 0.129 4.418689e-03 CTL_TRT
## Gm16133 1.625246e-06 2.5649120 0.044 0.184 4.875737e-03 CTL_TRT
## Ppp1r9a 1.701897e-06 1.5051665 0.242 0.313 5.105691e-03 CTL_TRT
## Sh3rf3 1.717067e-06 1.7290853 0.035 0.135 5.151202e-03 CTL_TRT
## Etl4 1.724559e-06 0.3412485 0.261 0.261 5.173678e-03 CTL_TRT
## Crim1 1.940214e-06 3.3890537 0.123 0.201 5.820643e-03 CTL_TRT
## Igfbp5 1.943390e-06 1.9127161 0.136 0.223 5.830169e-03 CTL_TRT
## Gap43 1.946053e-06 -1.8023093 0.332 0.379 5.838158e-03 CTL_TRT
## Arhgap29 2.034559e-06 -0.8197188 0.077 0.194 6.103677e-03 CTL_TRT
## Hpca 2.087428e-06 4.4073781 0.098 0.150 6.262283e-03 CTL_TRT
## Dnajc1 2.124024e-06 2.1308176 0.182 0.280 6.372073e-03 CTL_TRT
## Casp12 2.275974e-06 1.2782409 0.107 0.170 6.827921e-03 CTL_TRT
## Ldlrad4 2.386512e-06 2.7343204 0.188 0.218 7.159536e-03 CTL_TRT
## Isg15 2.481919e-06 1.9369517 0.261 0.243 7.445757e-03 CTL_TRT
## Wnt6 2.675884e-06 -1.3183423 0.088 0.215 8.027653e-03 CTL_TRT
## Tctn2 2.748862e-06 1.3329525 0.236 0.175 8.246585e-03 CTL_TRT
## 9330121J05Rik 2.851742e-06 2.7597153 0.033 0.152 8.555225e-03 CTL_TRT
## Ptges 2.947863e-06 0.7266319 0.031 0.184 8.843590e-03 CTL_TRT
## Hmgn3 2.968614e-06 0.3561592 0.331 0.299 8.905843e-03 CTL_TRT
## mt-Atp8 3.043849e-06 0.9536469 0.409 0.439 9.131547e-03 CTL_TRT
## Ift122 3.503115e-06 2.4380626 0.258 0.268 1.050935e-02 CTL_TRT
## P3h2 3.606358e-06 0.5995181 0.039 0.186 1.081907e-02 CTL_TRT
## Myoc 3.659797e-06 0.3840722 0.006 0.147 1.097939e-02 CTL_TRT
## Tie1 3.674702e-06 2.0845119 0.005 0.111 1.102410e-02 CTL_TRT
## Slc9a3r1 3.680856e-06 -1.9898027 0.216 0.243 1.104257e-02 CTL_TRT
## Pou4f1 3.718877e-06 0.5032373 0.357 0.323 1.115663e-02 CTL_TRT
## Olfml2a 3.730744e-06 1.6484890 0.061 0.186 1.119223e-02 CTL_TRT
## Cdh20 3.871070e-06 1.8440120 0.072 0.178 1.161321e-02 CTL_TRT
## Kcnh7 3.982070e-06 2.4404691 0.286 0.281 1.194621e-02 CTL_TRT
## Ghr 4.017643e-06 1.8161669 0.275 0.244 1.205293e-02 CTL_TRT
## Dio2 4.357227e-06 3.8207742 0.005 0.141 1.307168e-02 CTL_TRT
## Fancl 4.467752e-06 2.7002459 0.027 0.222 1.340326e-02 CTL_TRT
## Diaph2 4.559216e-06 1.3868205 0.266 0.305 1.367765e-02 CTL_TRT
## Scd1 4.653299e-06 2.5054244 0.390 0.374 1.395990e-02 CTL_TRT
## Aatk 4.793241e-06 -0.3373494 0.361 0.298 1.437972e-02 CTL_TRT
## 6330403K07Rik 4.904283e-06 2.0299042 0.262 0.274 1.471285e-02 CTL_TRT
## Hbegf 4.973965e-06 1.1062876 0.075 0.208 1.492190e-02 CTL_TRT
## Xkr4 5.043603e-06 -0.4055447 0.233 0.226 1.513081e-02 CTL_TRT
## Bc1 5.082116e-06 5.2007413 0.410 0.436 1.524635e-02 CTL_TRT
## Tmem45b 5.145819e-06 2.6926376 0.270 0.233 1.543746e-02 CTL_TRT
## Ppp2r3a 5.515911e-06 2.7621691 0.169 0.266 1.654773e-02 CTL_TRT
## Notch1 5.533980e-06 -1.5652594 0.129 0.210 1.660194e-02 CTL_TRT
## Esr1 5.826008e-06 1.2068998 0.056 0.123 1.747802e-02 CTL_TRT
## C78859 6.180033e-06 3.5635917 0.252 0.213 1.854010e-02 CTL_TRT
## Unc80 6.312416e-06 1.5245232 0.282 0.267 1.893725e-02 CTL_TRT
## Htr2c 7.223052e-06 3.3204738 0.002 0.119 2.166916e-02 CTL_TRT
## Fancc 7.341989e-06 2.3778274 0.081 0.220 2.202597e-02 CTL_TRT
## Cpne4 7.486206e-06 1.7960894 0.259 0.231 2.245862e-02 CTL_TRT
## Ldhb 8.028665e-06 1.5325464 0.397 0.434 2.408600e-02 CTL_TRT
## Nr2f2 8.181334e-06 1.4569887 0.218 0.319 2.454400e-02 CTL_TRT
## Hjurp 8.523492e-06 4.2169692 0.148 0.174 2.557048e-02 CTL_TRT
## Prrx1 8.773115e-06 0.5767947 0.012 0.184 2.631935e-02 CTL_TRT
## Maml3 8.985165e-06 -1.4964413 0.127 0.264 2.695549e-02 CTL_TRT
## Gm20631 9.205984e-06 3.3344394 0.012 0.138 2.761795e-02 CTL_TRT
## Aspa 9.291699e-06 1.2663260 0.239 0.261 2.787510e-02 CTL_TRT
## Hs6st3 9.654969e-06 2.3519953 0.257 0.223 2.896491e-02 CTL_TRT
## Slc17a7 1.046339e-05 0.7996515 0.239 0.229 3.139016e-02 CTL_TRT
## Nfkbia 1.058903e-05 2.1314413 0.205 0.288 3.176710e-02 CTL_TRT
## mt-Nd6 1.117174e-05 4.4584291 0.141 0.347 3.351521e-02 CTL_TRT
## Nkain4 1.125689e-05 2.5116201 0.128 0.154 3.377066e-02 CTL_TRT
## H2-Q7 1.146379e-05 0.9318417 0.012 0.191 3.439137e-02 CTL_TRT
## Ramp2 1.159054e-05 1.3313751 0.166 0.200 3.477163e-02 CTL_TRT
## Malat1 1.192776e-05 0.9561989 0.400 0.441 3.578327e-02 CTL_TRT
## Slc16a10 1.210856e-05 0.8777673 0.038 0.122 3.632567e-02 CTL_TRT
## Uhrf1 1.216387e-05 2.4755236 0.002 0.104 3.649162e-02 CTL_TRT
## Rgl1 1.217446e-05 -2.1377471 0.284 0.289 3.652339e-02 CTL_TRT
## Adamts4 1.328349e-05 1.0881196 0.009 0.196 3.985047e-02 CTL_TRT
## Col9a2 1.414956e-05 -2.0715470 0.017 0.245 4.244868e-02 CTL_TRT
## Lrrn1 1.420921e-05 0.3200759 0.323 0.272 4.262763e-02 CTL_TRT
## Mgst1 1.427499e-05 0.4936105 0.140 0.222 4.282498e-02 CTL_TRT
## Otop1 1.471717e-05 0.8763599 0.008 0.152 4.415151e-02 CTL_TRT
## Nos1 1.517892e-05 3.2988226 0.095 0.156 4.553676e-02 CTL_TRT
## Pdzrn3 1.580764e-05 0.5860182 0.114 0.186 4.742291e-02 CTL_TRT
## Col14a1 1.582094e-05 1.8458050 0.041 0.201 4.746281e-02 CTL_TRT
## Pwwp2a 1.593930e-05 3.7129635 0.203 0.206 4.781791e-02 CTL_TRT
## Klf12 1.604083e-05 1.5232344 0.145 0.199 4.812250e-02 CTL_TRT
## Mid1 1.678120e-05 -0.9423124 0.242 0.283 5.034359e-02 CTL_TRT
## Gsta4 1.715310e-05 0.3299349 0.124 0.204 5.145930e-02 CTL_TRT
## Plekha5 1.720682e-05 -0.2677935 0.301 0.254 5.162046e-02 CTL_TRT
## Jam2 1.726231e-05 0.3261477 0.139 0.184 5.178692e-02 CTL_TRT
## Sh3pxd2b 1.750711e-05 -2.6286344 0.127 0.175 5.252133e-02 CTL_TRT
## Pop5 1.760406e-05 0.7754134 0.388 0.379 5.281217e-02 CTL_TRT
## 1600010M07Rik 1.776710e-05 4.3268242 0.054 0.229 5.330131e-02 CTL_TRT
## Gm28376 1.805691e-05 1.9880524 0.044 0.130 5.417073e-02 CTL_TRT
## Lpar3 1.869959e-05 -1.0270590 0.202 0.176 5.609878e-02 CTL_TRT
## P2ry12 1.894937e-05 3.5494345 0.027 0.192 5.684812e-02 CTL_TRT
## Axl 1.921905e-05 1.4136167 0.058 0.175 5.765714e-02 CTL_TRT
## Ifi47 1.971683e-05 1.1372787 0.039 0.179 5.915049e-02 CTL_TRT
## Gm4258 2.071429e-05 6.2686921 0.130 0.182 6.214286e-02 CTL_TRT
## Mcam 2.108852e-05 -1.0870201 0.246 0.219 6.326557e-02 CTL_TRT
## Slitrk4 2.168890e-05 1.6526431 0.113 0.130 6.506670e-02 CTL_TRT
## Piezo2 2.368016e-05 2.1303795 0.332 0.307 7.104049e-02 CTL_TRT
## Rspo2 2.390558e-05 2.4205886 0.213 0.166 7.171673e-02 CTL_TRT
## Spock1 2.590790e-05 5.0953321 0.309 0.268 7.772370e-02 CTL_TRT
## Pcolce 2.743265e-05 1.6375730 0.025 0.172 8.229794e-02 CTL_TRT
## Crip2 2.930341e-05 0.8424233 0.404 0.422 8.791023e-02 CTL_TRT
## Myo16 2.982766e-05 0.3639828 0.058 0.189 8.948298e-02 CTL_TRT
## Gm26873 3.095896e-05 2.1229652 0.018 0.116 9.287689e-02 CTL_TRT
## Rasa3 3.329462e-05 1.8049842 0.077 0.214 9.988385e-02 CTL_TRT
## Naaladl2 3.354697e-05 -0.3398743 0.233 0.233 1.006409e-01 CTL_TRT
## Rbp1 3.443124e-05 -2.3820734 0.140 0.210 1.032937e-01 CTL_TRT
## Abca9 3.736049e-05 1.7244535 0.019 0.201 1.120815e-01 CTL_TRT
## Nrxn3 3.750268e-05 2.2083921 0.292 0.263 1.125080e-01 CTL_TRT
## Arhgef26 4.212910e-05 1.8093175 0.086 0.209 1.263873e-01 CTL_TRT
## Aldh1a1 4.218916e-05 1.1306344 0.009 0.158 1.265675e-01 CTL_TRT
## Cxcl10 4.260585e-05 0.9257501 0.216 0.198 1.278176e-01 CTL_TRT
## Sema3b 4.277072e-05 -0.5599016 0.247 0.278 1.283122e-01 CTL_TRT
## Rpl37 4.352907e-05 0.7066076 0.480 0.508 1.305872e-01 CTL_TRT
## Apod 4.451708e-05 -0.8349698 0.174 0.278 1.335512e-01 CTL_TRT
## B3galt1 4.651850e-05 1.6086917 0.243 0.200 1.395555e-01 CTL_TRT
## Kcnk5 4.790354e-05 2.3864422 0.038 0.212 1.437106e-01 CTL_TRT
## Lrrtm4 4.872377e-05 1.1644772 0.065 0.143 1.461713e-01 CTL_TRT
## Plcxd3 5.040346e-05 1.2101919 0.278 0.227 1.512104e-01 CTL_TRT
## Asic1 5.118652e-05 3.9228875 0.151 0.186 1.535596e-01 CTL_TRT
## Dipk2b 5.489373e-05 2.3701267 0.002 0.100 1.646812e-01 CTL_TRT
## Mecom 5.580832e-05 0.7459164 0.019 0.132 1.674250e-01 CTL_TRT
## 4931406C07Rik 5.700958e-05 3.5737983 0.098 0.208 1.710287e-01 CTL_TRT
## Stc1 5.868874e-05 0.8992926 0.001 0.115 1.760662e-01 CTL_TRT
## Lsamp 5.961927e-05 1.0312243 0.313 0.252 1.788578e-01 CTL_TRT
## Mctp2 6.642051e-05 2.0605993 0.208 0.169 1.992615e-01 CTL_TRT
## Trappc3l 6.744085e-05 2.7583577 0.265 0.308 2.023225e-01 CTL_TRT
## Adgrb3 6.829790e-05 1.8430725 0.341 0.319 2.048937e-01 CTL_TRT
## Ccnl1 7.049256e-05 0.8851652 0.235 0.331 2.114777e-01 CTL_TRT
## Efna5 7.222185e-05 3.1484738 0.243 0.233 2.166655e-01 CTL_TRT
## Arhgap6 7.256644e-05 1.8588939 0.043 0.127 2.176993e-01 CTL_TRT
## Tox3 7.546975e-05 4.8204529 0.168 0.187 2.264092e-01 CTL_TRT
## Cyp2d22 7.793935e-05 3.8189689 0.052 0.194 2.338180e-01 CTL_TRT
## Rit2 7.954575e-05 1.3920006 0.287 0.260 2.386373e-01 CTL_TRT
## Mdk 8.269504e-05 0.7192274 0.165 0.215 2.480851e-01 CTL_TRT
## Ifi30 9.211775e-05 1.9961500 0.055 0.195 2.763532e-01 CTL_TRT
## Ifit3 9.230834e-05 2.5914095 0.059 0.178 2.769250e-01 CTL_TRT
## Gpd1 9.597662e-05 3.8012140 0.059 0.153 2.879299e-01 CTL_TRT
## Stab1 9.792196e-05 1.2547925 0.009 0.133 2.937659e-01 CTL_TRT
## Shank2 9.964657e-05 1.7739150 0.056 0.163 2.989397e-01 CTL_TRT
## Gphn 1.012070e-04 1.1031878 0.382 0.421 3.036211e-01 CTL_TRT
## Ccdc60 1.063014e-04 3.0373759 0.066 0.160 3.189043e-01 CTL_TRT
## Col27a1 1.089403e-04 2.1200459 0.039 0.212 3.268209e-01 CTL_TRT
## Gm26788 1.120813e-04 5.7050119 0.007 0.178 3.362440e-01 CTL_TRT
## Kcnj10 1.202500e-04 3.8727328 0.163 0.211 3.607499e-01 CTL_TRT
## Csrp1 1.212678e-04 1.2878326 0.216 0.303 3.638035e-01 CTL_TRT
## P2ry14 1.235499e-04 0.6771098 0.081 0.139 3.706496e-01 CTL_TRT
## Nfia 1.268669e-04 1.5276727 0.376 0.390 3.806008e-01 CTL_TRT
## Car13 1.278067e-04 1.6832619 0.045 0.168 3.834201e-01 CTL_TRT
## Txndc16 1.285740e-04 6.7581600 0.165 0.205 3.857220e-01 CTL_TRT
## Shroom2 1.312554e-04 3.4739327 0.075 0.202 3.937663e-01 CTL_TRT
## Fbln5 1.358866e-04 3.2569874 0.299 0.260 4.076597e-01 CTL_TRT
## Tmsb10 1.374412e-04 0.3194697 0.435 0.444 4.123237e-01 CTL_TRT
## Ptprr 1.378618e-04 2.0436010 0.239 0.188 4.135855e-01 CTL_TRT
## Cd24a 1.527893e-04 2.0958944 0.384 0.404 4.583680e-01 CTL_TRT
## Rps20 1.560471e-04 -0.6083325 0.473 0.481 4.681413e-01 CTL_TRT
## Sh3bgrl3 1.616785e-04 -0.5941884 0.417 0.421 4.850355e-01 CTL_TRT
## Cdh4 1.764961e-04 1.8669055 0.081 0.170 5.294883e-01 CTL_TRT
## Plcd4 1.808976e-04 1.5808204 0.115 0.173 5.426927e-01 CTL_TRT
## Rapgef4 1.921210e-04 -0.9133873 0.298 0.264 5.763629e-01 CTL_TRT
## Ndrg1 1.984057e-04 -0.5213368 0.364 0.384 5.952172e-01 CTL_TRT
## Kcnc3 2.087293e-04 3.0579294 0.209 0.216 6.261879e-01 CTL_TRT
## Tnfaip6 2.113389e-04 0.9586115 0.079 0.184 6.340166e-01 CTL_TRT
## Parp14 2.129685e-04 1.0444423 0.095 0.220 6.389054e-01 CTL_TRT
## Abca8b 2.255867e-04 -3.2331443 0.171 0.254 6.767601e-01 CTL_TRT
## Syne3 2.495293e-04 2.2481251 0.053 0.197 7.485878e-01 CTL_TRT
## Dock10 2.554357e-04 2.6188816 0.202 0.251 7.663070e-01 CTL_TRT
## Unc13c 2.717216e-04 3.5033799 0.244 0.225 8.151647e-01 CTL_TRT
## Frmd4b 2.793631e-04 -1.0095663 0.279 0.253 8.380894e-01 CTL_TRT
## Syt2 2.981246e-04 1.7620268 0.278 0.279 8.943737e-01 CTL_TRT
## Dhrs3 3.003172e-04 1.7512887 0.017 0.219 9.009515e-01 CTL_TRT
## Ednrb 3.396481e-04 1.7709595 0.322 0.306 1.000000e+00 CTL_TRT
## Cdh11 3.479419e-04 4.2686641 0.370 0.326 1.000000e+00 CTL_TRT
## Egr2 3.492342e-04 -0.8257948 0.141 0.215 1.000000e+00 CTL_TRT
## Hmgcs2 3.514053e-04 0.6692127 0.205 0.248 1.000000e+00 CTL_TRT
## Calcb 3.687586e-04 0.9144548 0.375 0.334 1.000000e+00 CTL_TRT
## Kcna2 3.760940e-04 3.1072290 0.320 0.324 1.000000e+00 CTL_TRT
## Atp2b2 4.070502e-04 3.7532537 0.251 0.249 1.000000e+00 CTL_TRT
## Art3 4.077500e-04 4.3241699 0.183 0.272 1.000000e+00 CTL_TRT
## Acot1 4.166510e-04 2.7419139 0.161 0.200 1.000000e+00 CTL_TRT
## A930009A15Rik 4.204218e-04 1.5341060 0.045 0.199 1.000000e+00 CTL_TRT
## Adam23 4.236434e-04 2.2598338 0.339 0.317 1.000000e+00 CTL_TRT
## Fras1 4.251238e-04 1.8538176 0.053 0.178 1.000000e+00 CTL_TRT
## Add3 4.255609e-04 2.5329863 0.161 0.261 1.000000e+00 CTL_TRT
## Zic4 4.258724e-04 1.0317021 0.002 0.104 1.000000e+00 CTL_TRT
## Tnfaip8l1 4.278060e-04 2.6659894 0.024 0.198 1.000000e+00 CTL_TRT
## Syt1 4.371081e-04 0.4445776 0.351 0.311 1.000000e+00 CTL_TRT
## Ppargc1a 4.536369e-04 2.0140337 0.193 0.224 1.000000e+00 CTL_TRT
## Sema5a 4.612710e-04 2.5904332 0.159 0.225 1.000000e+00 CTL_TRT
## Slco6d1 4.946667e-04 4.1072148 0.004 0.161 1.000000e+00 CTL_TRT
## Hapln1 5.069766e-04 3.1220615 0.061 0.182 1.000000e+00 CTL_TRT
## Timp1 5.259134e-04 1.4355572 0.032 0.186 1.000000e+00 CTL_TRT
## Rabgap1l 5.284134e-04 -0.6375474 0.342 0.323 1.000000e+00 CTL_TRT
## Slc13a4 5.349705e-04 0.9491445 0.002 0.136 1.000000e+00 CTL_TRT
## Selenon 5.445896e-04 4.3769926 0.085 0.206 1.000000e+00 CTL_TRT
## Timp3 5.691513e-04 -1.7391882 0.346 0.374 1.000000e+00 CTL_TRT
## Lncpint 5.751766e-04 -1.6240458 0.350 0.360 1.000000e+00 CTL_TRT
## Pdgfb 6.116451e-04 1.1527411 0.011 0.168 1.000000e+00 CTL_TRT
## Magi1 6.261497e-04 0.4312023 0.346 0.329 1.000000e+00 CTL_TRT
## Fmn1 6.863301e-04 1.3326908 0.320 0.287 1.000000e+00 CTL_TRT
## Plcb4 6.933029e-04 0.8083946 0.187 0.281 1.000000e+00 CTL_TRT
## Bnc2 7.162308e-04 1.5422771 0.236 0.194 1.000000e+00 CTL_TRT
## Pdzd2 7.219227e-04 -0.5975549 0.234 0.324 1.000000e+00 CTL_TRT
## Sema3e 7.283122e-04 0.9783775 0.130 0.172 1.000000e+00 CTL_TRT
## Cyp2j9 7.339171e-04 4.5200249 0.095 0.192 1.000000e+00 CTL_TRT
## Col28a1 7.395732e-04 2.3090869 0.182 0.253 1.000000e+00 CTL_TRT
## Lvrn 7.495688e-04 1.9832271 0.061 0.149 1.000000e+00 CTL_TRT
## Rgs7 7.547265e-04 4.4703921 0.314 0.263 1.000000e+00 CTL_TRT
## Scn1b 7.600081e-04 -1.3116889 0.413 0.378 1.000000e+00 CTL_TRT
## Fgfr2 7.616129e-04 2.5481307 0.246 0.270 1.000000e+00 CTL_TRT
## 9530059O14Rik 7.668590e-04 2.4561811 0.302 0.283 1.000000e+00 CTL_TRT
## 4930595D18Rik 7.734666e-04 4.7891703 0.022 0.177 1.000000e+00 CTL_TRT
## Tns3 7.845657e-04 -0.7899182 0.184 0.230 1.000000e+00 CTL_TRT
## Snhg18 8.240845e-04 1.3405812 0.058 0.237 1.000000e+00 CTL_TRT
## Scn11a 8.823601e-04 1.7448804 0.377 0.355 1.000000e+00 CTL_TRT
## Gm50445 9.280459e-04 2.2325346 0.002 0.121 1.000000e+00 CTL_TRT
## Asxl1 9.519891e-04 9.9255003 0.268 0.284 1.000000e+00 CTL_TRT
## Arhgap24 9.620141e-04 2.3160531 0.219 0.296 1.000000e+00 CTL_TRT
## Frmpd4 9.620566e-04 0.9601913 0.166 0.127 1.000000e+00 CTL_TRT
## Gm26749 1.006680e-03 2.7106871 0.014 0.160 1.000000e+00 CTL_TRT
## Emp3 1.017028e-03 1.9994501 0.355 0.374 1.000000e+00 CTL_TRT
## Scn10a 1.066319e-03 -0.3490299 0.396 0.357 1.000000e+00 CTL_TRT
## Gbp2 1.076668e-03 0.5949739 0.091 0.147 1.000000e+00 CTL_TRT
## Serping1 1.077595e-03 1.5758742 0.195 0.227 1.000000e+00 CTL_TRT
## Il1rapl1 1.077658e-03 2.1046723 0.327 0.321 1.000000e+00 CTL_TRT
## Top2a 1.082792e-03 -0.6191554 0.004 0.191 1.000000e+00 CTL_TRT
## Litaf 1.112783e-03 6.2171167 0.261 0.276 1.000000e+00 CTL_TRT
## Entpd1 1.135399e-03 1.5450931 0.056 0.176 1.000000e+00 CTL_TRT
## Atp8b1 1.180626e-03 1.5572749 0.010 0.219 1.000000e+00 CTL_TRT
## Csmd1 1.268896e-03 0.8125013 0.306 0.268 1.000000e+00 CTL_TRT
## Gm47283 1.271073e-03 -1.7555055 0.391 0.325 1.000000e+00 CTL_TRT
## Celf4 1.302584e-03 -0.4328994 0.298 0.299 1.000000e+00 CTL_TRT
## Atpif1 1.331659e-03 0.8379892 0.467 0.473 1.000000e+00 CTL_TRT
## Ptpn13 1.355861e-03 8.3531841 0.239 0.271 1.000000e+00 CTL_TRT
## Angptl4 1.361955e-03 2.2100216 0.210 0.215 1.000000e+00 CTL_TRT
## Tex14 1.369172e-03 3.4155017 0.093 0.189 1.000000e+00 CTL_TRT
## Prkd1 1.374160e-03 1.5294721 0.303 0.267 1.000000e+00 CTL_TRT
## Cadps 1.384544e-03 0.9776530 0.380 0.355 1.000000e+00 CTL_TRT
## Serpinh1 1.397575e-03 1.2819268 0.097 0.225 1.000000e+00 CTL_TRT
## Rapgef6 1.425339e-03 2.6502278 0.354 0.379 1.000000e+00 CTL_TRT
## Nedd4l 1.431148e-03 -0.3118048 0.351 0.337 1.000000e+00 CTL_TRT
## Nckap5 1.443759e-03 -0.6692121 0.100 0.212 1.000000e+00 CTL_TRT
## Gm6994 1.466341e-03 4.7568732 0.024 0.145 1.000000e+00 CTL_TRT
## Bbof1 1.516530e-03 3.2823867 0.032 0.187 1.000000e+00 CTL_TRT
## Wwtr1 1.516681e-03 2.7265898 0.185 0.237 1.000000e+00 CTL_TRT
## Igf1 1.562397e-03 1.4371238 0.019 0.139 1.000000e+00 CTL_TRT
## Ndrg2 1.627999e-03 1.9042061 0.362 0.331 1.000000e+00 CTL_TRT
## Sorbs1 1.634057e-03 1.4678780 0.392 0.399 1.000000e+00 CTL_TRT
## Cp 1.647817e-03 -0.5617314 0.174 0.255 1.000000e+00 CTL_TRT
## Tbx15 1.804677e-03 2.0490222 0.004 0.139 1.000000e+00 CTL_TRT
## C3 1.815554e-03 1.2071153 0.003 0.103 1.000000e+00 CTL_TRT
## Negr1 1.865649e-03 1.3684028 0.176 0.214 1.000000e+00 CTL_TRT
## Mag 1.879144e-03 -0.5184153 0.036 0.189 1.000000e+00 CTL_TRT
## Tbx2 1.935534e-03 0.7487634 0.076 0.176 1.000000e+00 CTL_TRT
## Ralgapa2 2.011359e-03 1.3707133 0.223 0.207 1.000000e+00 CTL_TRT
## Nid2 2.027111e-03 2.5126822 0.034 0.169 1.000000e+00 CTL_TRT
## Cst3 2.041958e-03 -0.3436971 0.354 0.388 1.000000e+00 CTL_TRT
## Matn4 2.044451e-03 1.2917555 0.105 0.159 1.000000e+00 CTL_TRT
## Gm42695 2.087963e-03 1.5701785 0.004 0.215 1.000000e+00 CTL_TRT
## Gas1 2.116495e-03 3.3203734 0.020 0.174 1.000000e+00 CTL_TRT
## Htra3 2.148261e-03 -0.9951535 0.008 0.204 1.000000e+00 CTL_TRT
## Hdac9 2.349465e-03 0.9997588 0.275 0.231 1.000000e+00 CTL_TRT
## Syp 2.482515e-03 0.8747536 0.397 0.338 1.000000e+00 CTL_TRT
## Ptch1 2.522056e-03 -2.2224985 0.172 0.270 1.000000e+00 CTL_TRT
## Atp1a3 2.535490e-03 2.4082250 0.379 0.382 1.000000e+00 CTL_TRT
## S100a9 2.553053e-03 0.8574193 0.014 0.204 1.000000e+00 CTL_TRT
## Rpl41 2.594853e-03 0.8330909 0.472 0.486 1.000000e+00 CTL_TRT
## Stard13 2.610095e-03 -0.4648194 0.368 0.382 1.000000e+00 CTL_TRT
## Mcpt4 2.622888e-03 0.3656860 0.001 0.217 1.000000e+00 CTL_TRT
## Sulf1 2.789000e-03 0.7209377 0.232 0.262 1.000000e+00 CTL_TRT
## Stox2 2.844080e-03 2.5891949 0.284 0.328 1.000000e+00 CTL_TRT
## Srgap2 2.854721e-03 -2.8892371 0.245 0.291 1.000000e+00 CTL_TRT
## Auts2 2.976640e-03 -2.8076730 0.382 0.359 1.000000e+00 CTL_TRT
## Colec12 3.086804e-03 3.6493602 0.005 0.187 1.000000e+00 CTL_TRT
## Shc3 3.144025e-03 0.5606434 0.032 0.233 1.000000e+00 CTL_TRT
## Orc1 3.167428e-03 2.9443557 0.079 0.114 1.000000e+00 CTL_TRT
## Hs3st5 3.243822e-03 2.4616796 0.249 0.208 1.000000e+00 CTL_TRT
## Stmn3 3.249275e-03 0.6910516 0.454 0.462 1.000000e+00 CTL_TRT
## Dtx1 3.249577e-03 1.5647947 0.002 0.150 1.000000e+00 CTL_TRT
## Gm26658 3.405598e-03 1.9358646 0.041 0.119 1.000000e+00 CTL_TRT
## Edn1 3.411524e-03 0.7414930 0.002 0.118 1.000000e+00 CTL_TRT
## Kcnd3 3.555086e-03 3.6537729 0.244 0.194 1.000000e+00 CTL_TRT
## Homer1 3.565063e-03 2.0624022 0.181 0.216 1.000000e+00 CTL_TRT
## B2m 3.575301e-03 2.1559502 0.373 0.390 1.000000e+00 CTL_TRT
## Nr6a1 3.671612e-03 -0.3817108 0.300 0.292 1.000000e+00 CTL_TRT
## Sntb1 3.820908e-03 -1.8727362 0.226 0.273 1.000000e+00 CTL_TRT
## Dnmbp 3.932469e-03 4.6843188 0.095 0.122 1.000000e+00 CTL_TRT
## Gm765 4.020253e-03 -0.7518410 0.266 0.256 1.000000e+00 CTL_TRT
## Mpz 4.043809e-03 0.4823707 0.285 0.306 1.000000e+00 CTL_TRT
## Tgfbr3 4.091085e-03 1.1785793 0.254 0.304 1.000000e+00 CTL_TRT
## Strbp 4.188560e-03 0.7590864 0.266 0.287 1.000000e+00 CTL_TRT
## Cog5 4.273505e-03 7.9006362 0.232 0.228 1.000000e+00 CTL_TRT
## Cacna2d3 4.315580e-03 2.6496607 0.232 0.198 1.000000e+00 CTL_TRT
## Atp1a1 4.341320e-03 1.8988306 0.400 0.408 1.000000e+00 CTL_TRT
## Rsad2 4.353338e-03 1.3372147 0.042 0.151 1.000000e+00 CTL_TRT
## Cryab 4.353677e-03 -0.4583578 0.337 0.372 1.000000e+00 CTL_TRT
## Col5a2 4.425453e-03 1.2355413 0.133 0.223 1.000000e+00 CTL_TRT
## Cpne6 4.545780e-03 6.9362116 0.278 0.315 1.000000e+00 CTL_TRT
## Gm26532 4.644083e-03 -2.3440455 0.202 0.210 1.000000e+00 CTL_TRT
## Dgkz 4.836098e-03 3.9696544 0.390 0.338 1.000000e+00 CTL_TRT
## Ftl1 4.842689e-03 -1.0450137 0.457 0.452 1.000000e+00 CTL_TRT
## Kalrn 5.412369e-03 1.9998323 0.246 0.222 1.000000e+00 CTL_TRT
## mt-Nd4 5.428834e-03 0.3840923 0.454 0.483 1.000000e+00 CTL_TRT
## Fa2h 5.500099e-03 1.4992726 0.020 0.214 1.000000e+00 CTL_TRT
## Grm8 5.524369e-03 1.8854309 0.139 0.120 1.000000e+00 CTL_TRT
## Paqr6 5.528996e-03 3.0891087 0.128 0.166 1.000000e+00 CTL_TRT
## F3 5.648029e-03 1.8678440 0.136 0.202 1.000000e+00 CTL_TRT
## Rnf213 5.677769e-03 3.9456613 0.089 0.212 1.000000e+00 CTL_TRT
## Plin3 5.757865e-03 0.9055609 0.066 0.182 1.000000e+00 CTL_TRT
## Tbc1d10a 5.775713e-03 0.7444665 0.129 0.145 1.000000e+00 CTL_TRT
## Ank2 5.830953e-03 1.3381757 0.312 0.287 1.000000e+00 CTL_TRT
## Camk1d 5.851735e-03 1.3053212 0.261 0.399 1.000000e+00 CTL_TRT
## Icam2 5.898554e-03 1.2479423 0.005 0.105 1.000000e+00 CTL_TRT
## Kcna1 5.917167e-03 3.3138272 0.261 0.347 1.000000e+00 CTL_TRT
## Usp53 6.025337e-03 -4.8685673 0.177 0.218 1.000000e+00 CTL_TRT
## Itgb8 6.039979e-03 1.4875524 0.312 0.309 1.000000e+00 CTL_TRT
## Notch2 6.070734e-03 3.0271076 0.056 0.208 1.000000e+00 CTL_TRT
## Itm2b 6.158664e-03 0.5432353 0.408 0.387 1.000000e+00 CTL_TRT
## Ank3 6.448206e-03 5.3283596 0.373 0.373 1.000000e+00 CTL_TRT
## Dmd 6.479207e-03 2.4639822 0.388 0.387 1.000000e+00 CTL_TRT
## Camk2a 6.521807e-03 -4.1622364 0.313 0.289 1.000000e+00 CTL_TRT
## Dip2c 6.592711e-03 0.9172373 0.334 0.324 1.000000e+00 CTL_TRT
## Galnt13 6.653279e-03 3.2091087 0.257 0.210 1.000000e+00 CTL_TRT
## Gbp3 6.747670e-03 0.8281713 0.040 0.182 1.000000e+00 CTL_TRT
## Lonrf3 7.165855e-03 2.5158058 0.008 0.202 1.000000e+00 CTL_TRT
## Fgf13 7.195048e-03 0.4359115 0.415 0.423 1.000000e+00 CTL_TRT
## Pde1c 7.478256e-03 3.7557158 0.239 0.192 1.000000e+00 CTL_TRT
## 2610307P16Rik 7.503509e-03 3.0710048 0.176 0.219 1.000000e+00 CTL_TRT
## S1pr3 7.552017e-03 0.5215493 0.307 0.297 1.000000e+00 CTL_TRT
## Jmjd1c 7.616228e-03 1.1514429 0.369 0.373 1.000000e+00 CTL_TRT
## Pole2 8.065085e-03 2.3194124 0.018 0.227 1.000000e+00 CTL_TRT
## Smpd2 8.154346e-03 -0.8170521 0.038 0.186 1.000000e+00 CTL_TRT
## Gpc4 8.189120e-03 3.2977601 0.034 0.200 1.000000e+00 CTL_TRT
## Cntf 8.280011e-03 -0.2644689 0.069 0.179 1.000000e+00 CTL_TRT
## Enox1 8.391168e-03 -0.8470400 0.335 0.309 1.000000e+00 CTL_TRT
## Agmo 8.570800e-03 -0.7479387 0.052 0.164 1.000000e+00 CTL_TRT
## Nwd2 8.627741e-03 4.0992824 0.286 0.251 1.000000e+00 CTL_TRT
## Large1 8.882488e-03 2.1026812 0.316 0.300 1.000000e+00 CTL_TRT
## Gm19705 9.685199e-03 4.0819287 0.045 0.152 1.000000e+00 CTL_TRT
## Erg 9.695293e-03 0.9237190 0.008 0.128 1.000000e+00 CTL_TRT
## Basp1 9.781528e-03 0.3768628 0.411 0.412 1.000000e+00 CTL_TRT
## Hk2 9.818794e-03 1.1545273 0.022 0.231 1.000000e+00 CTL_TRT
## Cxcl1 9.988069e-03 2.1469668 0.029 0.179 1.000000e+00 CTL_TRT
## Nipal1 1.004806e-02 0.2627918 0.013 0.195 1.000000e+00 CTL_TRT
## Wdr95 1.009092e-02 1.8550943 0.008 0.106 1.000000e+00 CTL_TRT
## Sgcd 1.030449e-02 0.7492088 0.293 0.255 1.000000e+00 CTL_TRT
## Cntnap2 1.041568e-02 0.4772142 0.253 0.212 1.000000e+00 CTL_TRT
## Sorcs3 1.047920e-02 1.2547003 0.104 0.127 1.000000e+00 CTL_TRT
## Fkbp1b 1.075047e-02 -2.9268207 0.384 0.382 1.000000e+00 CTL_TRT
## Plxdc2 1.086773e-02 2.2792502 0.239 0.315 1.000000e+00 CTL_TRT
## Tjp1 1.111549e-02 -2.8980485 0.216 0.265 1.000000e+00 CTL_TRT
## Sept9 1.157872e-02 1.8523866 0.131 0.217 1.000000e+00 CTL_TRT
## mt-Nd5 1.159641e-02 -1.4703846 0.415 0.439 1.000000e+00 CTL_TRT
## Adamts20 1.165725e-02 1.6720481 0.037 0.178 1.000000e+00 CTL_TRT
## B4galnt3 1.172113e-02 3.2319246 0.005 0.169 1.000000e+00 CTL_TRT
## Morrbid 1.173433e-02 1.5927567 0.154 0.177 1.000000e+00 CTL_TRT
## Apcdd1 1.174603e-02 0.9394340 0.008 0.142 1.000000e+00 CTL_TRT
## Adk 1.198270e-02 1.8890962 0.319 0.321 1.000000e+00 CTL_TRT
## Gfpt2 1.216255e-02 3.4886338 0.007 0.135 1.000000e+00 CTL_TRT
## Cyp4f15 1.221575e-02 2.9510996 0.029 0.154 1.000000e+00 CTL_TRT
## Drp2 1.235644e-02 -0.4949404 0.138 0.236 1.000000e+00 CTL_TRT
## Kirrel3 1.236868e-02 1.7393852 0.211 0.187 1.000000e+00 CTL_TRT
## Nostrin 1.247777e-02 4.8147939 0.005 0.177 1.000000e+00 CTL_TRT
## Col3a1 1.269423e-02 1.9935489 0.073 0.174 1.000000e+00 CTL_TRT
## Bcl2l11 1.281418e-02 3.8872028 0.073 0.216 1.000000e+00 CTL_TRT
## Nr4a3 1.283532e-02 -1.5725119 0.081 0.194 1.000000e+00 CTL_TRT
## Abhd4 1.283546e-02 0.8924378 0.190 0.235 1.000000e+00 CTL_TRT
## Ldb2 1.295374e-02 0.6970732 0.339 0.322 1.000000e+00 CTL_TRT
## Pdlim4 1.299102e-02 1.7327478 0.172 0.213 1.000000e+00 CTL_TRT
## Abca8a 1.332053e-02 2.0132659 0.343 0.335 1.000000e+00 CTL_TRT
## Fabp5 1.353222e-02 2.1756516 0.411 0.426 1.000000e+00 CTL_TRT
## I730030J21Rik 1.370168e-02 1.4756063 0.068 0.156 1.000000e+00 CTL_TRT
## Spock3 1.386441e-02 -3.7766246 0.272 0.242 1.000000e+00 CTL_TRT
## Lpar6 1.396292e-02 0.2924186 0.028 0.183 1.000000e+00 CTL_TRT
## Epb41l2 1.412903e-02 2.5179871 0.236 0.290 1.000000e+00 CTL_TRT
## Plekhb1 1.444365e-02 -0.8517122 0.176 0.265 1.000000e+00 CTL_TRT
## Pln 1.448188e-02 3.2921966 0.034 0.174 1.000000e+00 CTL_TRT
## Camk2d 1.462281e-02 -1.3871953 0.389 0.385 1.000000e+00 CTL_TRT
## Ermp1 1.464404e-02 2.8957425 0.252 0.251 1.000000e+00 CTL_TRT
## Ano6 1.497830e-02 3.3642467 0.265 0.284 1.000000e+00 CTL_TRT
## Mt1 1.600454e-02 -0.4611563 0.327 0.362 1.000000e+00 CTL_TRT
## Cmtm5 1.601413e-02 -1.7768884 0.252 0.261 1.000000e+00 CTL_TRT
## Cfh 1.619276e-02 1.9231063 0.017 0.153 1.000000e+00 CTL_TRT
## Alas1 1.673806e-02 5.5002451 0.071 0.175 1.000000e+00 CTL_TRT
## Cacnb4 1.724449e-02 -0.2565853 0.345 0.317 1.000000e+00 CTL_TRT
## Mrgpra2b 1.744740e-02 -2.0259288 0.253 0.246 1.000000e+00 CTL_TRT
## Sdk1 1.745735e-02 3.4033277 0.264 0.299 1.000000e+00 CTL_TRT
## Paqr5 1.783402e-02 0.8743578 0.248 0.221 1.000000e+00 CTL_TRT
## Calm1 1.797897e-02 0.4059185 0.457 0.465 1.000000e+00 CTL_TRT
## Zbtb20 1.798478e-02 0.9095742 0.426 0.436 1.000000e+00 CTL_TRT
## Vldlr 1.804660e-02 1.0633394 0.169 0.212 1.000000e+00 CTL_TRT
## Hs6st2 1.833160e-02 3.1714378 0.306 0.283 1.000000e+00 CTL_TRT
## Fgfr1 1.887201e-02 0.6202769 0.319 0.320 1.000000e+00 CTL_TRT
## Rgs7bp 1.891763e-02 1.6044496 0.409 0.391 1.000000e+00 CTL_TRT
## Vwa1 2.071448e-02 -1.7719245 0.176 0.223 1.000000e+00 CTL_TRT
## Dpp10 2.130168e-02 1.8584049 0.246 0.204 1.000000e+00 CTL_TRT
## Zfp866 2.143192e-02 5.8717892 0.031 0.147 1.000000e+00 CTL_TRT
## Syt4 2.153515e-02 1.0342212 0.397 0.391 1.000000e+00 CTL_TRT
## B3gnt5 2.156566e-02 0.5024121 0.049 0.158 1.000000e+00 CTL_TRT
## Tpm2 2.163245e-02 -1.0954467 0.044 0.138 1.000000e+00 CTL_TRT
## Sphkap 2.170320e-02 1.7965927 0.135 0.193 1.000000e+00 CTL_TRT
## Pkd1l3 2.214252e-02 4.1200538 0.104 0.165 1.000000e+00 CTL_TRT
## Cacna1c 2.217570e-02 2.4878819 0.306 0.305 1.000000e+00 CTL_TRT
## Pde10a 2.323517e-02 -0.7774031 0.190 0.248 1.000000e+00 CTL_TRT
## Adgrg6 2.352820e-02 3.9127237 0.165 0.225 1.000000e+00 CTL_TRT
## Cnn3 2.361829e-02 0.9467052 0.386 0.371 1.000000e+00 CTL_TRT
## Nebl 2.405461e-02 -1.5676589 0.284 0.235 1.000000e+00 CTL_TRT
## Il15 2.413711e-02 1.5646076 0.004 0.207 1.000000e+00 CTL_TRT
## Dock4 2.458040e-02 1.6138172 0.245 0.211 1.000000e+00 CTL_TRT
## Prss23 2.460357e-02 1.1438528 0.049 0.177 1.000000e+00 CTL_TRT
## Glis3 2.474533e-02 -0.4790587 0.057 0.166 1.000000e+00 CTL_TRT
## Egfem1 2.570073e-02 1.9072092 0.230 0.169 1.000000e+00 CTL_TRT
## Gabra2 2.582296e-02 1.5222364 0.208 0.192 1.000000e+00 CTL_TRT
## Cybrd1 2.589444e-02 2.8652768 0.042 0.208 1.000000e+00 CTL_TRT
## Bicc1 2.631466e-02 3.7663196 0.081 0.195 1.000000e+00 CTL_TRT
## Tshz2 2.634314e-02 -1.7066363 0.406 0.390 1.000000e+00 CTL_TRT
## Alcam 2.638340e-02 1.1631676 0.378 0.368 1.000000e+00 CTL_TRT
## Thsd7a 2.657845e-02 0.8927708 0.274 0.273 1.000000e+00 CTL_TRT
## Fbln2 2.659253e-02 2.0789901 0.224 0.279 1.000000e+00 CTL_TRT
## Fuca1 2.711718e-02 7.6402676 0.185 0.277 1.000000e+00 CTL_TRT
## Pde5a 2.747005e-02 0.2739515 0.010 0.199 1.000000e+00 CTL_TRT
## Nfib 2.774175e-02 0.3886224 0.297 0.361 1.000000e+00 CTL_TRT
## Plaat3 2.872037e-02 1.1934156 0.231 0.283 1.000000e+00 CTL_TRT
## Gm36975 2.895386e-02 4.0571951 0.056 0.200 1.000000e+00 CTL_TRT
## mt-Nd2 2.902911e-02 0.2692546 0.438 0.461 1.000000e+00 CTL_TRT
## Ankub1 2.962517e-02 1.9997338 0.007 0.224 1.000000e+00 CTL_TRT
## Kidins220 2.998034e-02 4.5077512 0.383 0.378 1.000000e+00 CTL_TRT
## Cnmd 3.022952e-02 2.5815106 0.066 0.177 1.000000e+00 CTL_TRT
## Rhoj 3.053152e-02 -1.2508558 0.132 0.254 1.000000e+00 CTL_TRT
## Hs3st2 3.064114e-02 3.7199686 0.130 0.178 1.000000e+00 CTL_TRT
## Scg2 3.091523e-02 2.4971856 0.302 0.334 1.000000e+00 CTL_TRT
## Hbb-bs 3.105596e-02 0.3424337 0.227 0.332 1.000000e+00 CTL_TRT
## Tmem117 3.347025e-02 0.7728397 0.262 0.220 1.000000e+00 CTL_TRT
## Cotl1 3.374927e-02 -1.6777882 0.083 0.217 1.000000e+00 CTL_TRT
## Tesk2 3.389856e-02 -0.8861592 0.075 0.203 1.000000e+00 CTL_TRT
## Lgr4 3.431085e-02 -2.5602025 0.292 0.290 1.000000e+00 CTL_TRT
## Xdh 3.475789e-02 1.1464410 0.010 0.118 1.000000e+00 CTL_TRT
## Cald1 3.545580e-02 -2.4517555 0.194 0.278 1.000000e+00 CTL_TRT
## Airn 3.547023e-02 2.2880187 0.115 0.176 1.000000e+00 CTL_TRT
## Ccar1 3.612312e-02 10.0480992 0.224 0.272 1.000000e+00 CTL_TRT
## Plp1 3.792807e-02 1.9501413 0.344 0.336 1.000000e+00 CTL_TRT
## Tspan18 3.885641e-02 0.3494732 0.136 0.202 1.000000e+00 CTL_TRT
## Rora 3.899853e-02 -0.2884956 0.302 0.333 1.000000e+00 CTL_TRT
## Filip1 4.005652e-02 0.4067892 0.219 0.240 1.000000e+00 CTL_TRT
## Zfp521 4.342820e-02 2.7981091 0.203 0.203 1.000000e+00 CTL_TRT
## Prkn 4.361831e-02 -1.9413720 0.300 0.283 1.000000e+00 CTL_TRT
## Cited2 4.376943e-02 2.3620544 0.123 0.221 1.000000e+00 CTL_TRT
## Sp100 4.387389e-02 1.4149053 0.015 0.122 1.000000e+00 CTL_TRT
## Megf11 4.395042e-02 1.2051932 0.022 0.196 1.000000e+00 CTL_TRT
## Tfap2a 4.509382e-02 1.8609515 0.032 0.176 1.000000e+00 CTL_TRT
## Lrp1b 4.514248e-02 0.8319205 0.232 0.185 1.000000e+00 CTL_TRT
## Marcks 4.740107e-02 0.9706555 0.425 0.398 1.000000e+00 CTL_TRT
## Opcml 4.836188e-02 0.7806703 0.244 0.216 1.000000e+00 CTL_TRT
## Nol9 4.836938e-02 4.7275809 0.030 0.240 1.000000e+00 CTL_TRT
## Faah 4.917896e-02 2.1271914 0.069 0.200 1.000000e+00 CTL_TRT
## 2900060N12Rik 5.030206e-02 2.4101470 0.008 0.160 1.000000e+00 CTL_TRT
## Ywhah 5.058630e-02 1.6919611 0.439 0.441 1.000000e+00 CTL_TRT
## Lrrc4c 5.076237e-02 -0.7123911 0.308 0.316 1.000000e+00 CTL_TRT
## Atp8a2 5.144609e-02 0.3638979 0.310 0.305 1.000000e+00 CTL_TRT
## Ak5 5.173374e-02 -3.1505039 0.192 0.197 1.000000e+00 CTL_TRT
## Gm38405 5.301522e-02 2.0727982 0.003 0.106 1.000000e+00 CTL_TRT
## Atxn1 5.302688e-02 0.7088545 0.327 0.325 1.000000e+00 CTL_TRT
## Bach2 5.318615e-02 5.1053582 0.338 0.312 1.000000e+00 CTL_TRT
## Apoc1 5.370065e-02 4.0028210 0.096 0.168 1.000000e+00 CTL_TRT
## Cdh10 5.428695e-02 3.5451161 0.118 0.145 1.000000e+00 CTL_TRT
## Vim 5.612842e-02 1.2244490 0.345 0.351 1.000000e+00 CTL_TRT
## Trim30d 5.883723e-02 1.6882321 0.003 0.105 1.000000e+00 CTL_TRT
## Grik2 6.118944e-02 0.6661763 0.297 0.309 1.000000e+00 CTL_TRT
## Fat1 6.251255e-02 1.3285856 0.126 0.166 1.000000e+00 CTL_TRT
## Alpl 6.400422e-02 1.1550263 0.032 0.170 1.000000e+00 CTL_TRT
## Gask1b 6.447534e-02 2.4365043 0.098 0.189 1.000000e+00 CTL_TRT
## Pecam1 6.494213e-02 -1.2263058 0.017 0.146 1.000000e+00 CTL_TRT
## Grid2 6.801320e-02 0.9140592 0.336 0.330 1.000000e+00 CTL_TRT
## Phgdh 6.818025e-02 0.8027223 0.236 0.246 1.000000e+00 CTL_TRT
## Kcnq3 6.989173e-02 2.7217170 0.127 0.141 1.000000e+00 CTL_TRT
## Ramp1 6.998666e-02 0.8880064 0.010 0.140 1.000000e+00 CTL_TRT
## Tent5a 7.042384e-02 -1.7040599 0.059 0.216 1.000000e+00 CTL_TRT
## Kcnb2 7.120917e-02 0.7020268 0.319 0.296 1.000000e+00 CTL_TRT
## Secisbp2l 7.157464e-02 -1.3202056 0.263 0.324 1.000000e+00 CTL_TRT
## Rarres2 7.315500e-02 1.1877731 0.278 0.303 1.000000e+00 CTL_TRT
## Gm49678 7.473957e-02 1.8958309 0.236 0.182 1.000000e+00 CTL_TRT
## Tiparp 7.581144e-02 4.7448232 0.340 0.356 1.000000e+00 CTL_TRT
## Galnt17 7.734099e-02 -3.7713334 0.355 0.339 1.000000e+00 CTL_TRT
## Pmp22 7.873400e-02 0.5443788 0.359 0.383 1.000000e+00 CTL_TRT
## Lhfpl3 7.951629e-02 1.2676646 0.246 0.185 1.000000e+00 CTL_TRT
## Prune2 8.018084e-02 1.3629278 0.395 0.386 1.000000e+00 CTL_TRT
## Sh3d19 8.092093e-02 2.0835559 0.286 0.318 1.000000e+00 CTL_TRT
## Musk 8.136548e-02 3.2448080 0.014 0.215 1.000000e+00 CTL_TRT
## Syne2 8.142822e-02 5.1853445 0.164 0.275 1.000000e+00 CTL_TRT
## Acvrl1 8.189532e-02 -0.4248110 0.010 0.163 1.000000e+00 CTL_TRT
## Mboat2 8.286823e-02 3.8893788 0.279 0.288 1.000000e+00 CTL_TRT
## AU020206 8.377663e-02 1.0501666 0.010 0.185 1.000000e+00 CTL_TRT
## Gria2 8.400869e-02 3.3098592 0.187 0.185 1.000000e+00 CTL_TRT
## Mamdc2 8.460152e-02 1.9698117 0.046 0.184 1.000000e+00 CTL_TRT
## Ncam2 8.557556e-02 1.2597344 0.336 0.309 1.000000e+00 CTL_TRT
## Gm29683 8.642457e-02 1.7752458 0.033 0.183 1.000000e+00 CTL_TRT
## Slc24a2 8.967419e-02 -1.3486650 0.346 0.340 1.000000e+00 CTL_TRT
## Irgm2 9.028103e-02 1.3225018 0.061 0.198 1.000000e+00 CTL_TRT
## Sema6d 9.077140e-02 4.7830882 0.304 0.278 1.000000e+00 CTL_TRT
## Tenm3 9.082654e-02 2.8513763 0.337 0.340 1.000000e+00 CTL_TRT
## Gm13403 9.205606e-02 1.4707116 0.004 0.156 1.000000e+00 CTL_TRT
## A330015K06Rik 9.364564e-02 3.9544981 0.022 0.211 1.000000e+00 CTL_TRT
## Clstn2 9.366421e-02 1.4113855 0.221 0.188 1.000000e+00 CTL_TRT
## Lcat 9.403794e-02 2.1873178 0.029 0.168 1.000000e+00 CTL_TRT
## Btbd16 9.413035e-02 2.7189499 0.005 0.115 1.000000e+00 CTL_TRT
## Lgi2 9.528745e-02 2.3194990 0.148 0.186 1.000000e+00 CTL_TRT
## Hivep2 9.611242e-02 0.2569274 0.377 0.401 1.000000e+00 CTL_TRT
## Prdm1 9.612314e-02 2.4768810 0.020 0.176 1.000000e+00 CTL_TRT
## Sncg 9.617675e-02 0.8464965 0.389 0.388 1.000000e+00 CTL_TRT
## Gm45169 9.633690e-02 2.6416524 0.007 0.176 1.000000e+00 CTL_TRT
## Adgrl3 9.766587e-02 0.7684291 0.380 0.351 1.000000e+00 CTL_TRT
## Hint1 9.784473e-02 0.3033942 0.478 0.477 1.000000e+00 CTL_TRT
## Reep3 9.827539e-02 1.5384801 0.261 0.297 1.000000e+00 CTL_TRT
## Pde7b 9.946454e-02 1.9805081 0.199 0.279 1.000000e+00 CTL_TRT
## Adm 9.984986e-02 3.5699351 0.006 0.183 1.000000e+00 CTL_TRT
## Wdr17 1.000191e-01 3.2035263 0.097 0.188 1.000000e+00 CTL_TRT
## Eif2b3 1.017141e-01 3.4261543 0.104 0.171 1.000000e+00 CTL_TRT
## Sat1 1.028971e-01 0.3917194 0.371 0.382 1.000000e+00 CTL_TRT
## Plod2 1.031542e-01 3.4625378 0.046 0.153 1.000000e+00 CTL_TRT
## Rab8b 1.031865e-01 4.8795859 0.217 0.273 1.000000e+00 CTL_TRT
## Rapgef2 1.053393e-01 1.2431920 0.247 0.278 1.000000e+00 CTL_TRT
## Crabp1 1.055408e-01 2.0175447 0.062 0.133 1.000000e+00 CTL_TRT
## Pcsk1n 1.070677e-01 4.0564092 0.420 0.400 1.000000e+00 CTL_TRT
## Jag1 1.073718e-01 2.5917802 0.076 0.160 1.000000e+00 CTL_TRT
## Atp5md 1.083079e-01 9.9912343 0.440 0.442 1.000000e+00 CTL_TRT
## Endod1 1.093273e-01 1.6875788 0.366 0.367 1.000000e+00 CTL_TRT
## mt-Atp6 1.095065e-01 -0.3457402 0.477 0.490 1.000000e+00 CTL_TRT
## Sdc4 1.096547e-01 2.5442628 0.292 0.307 1.000000e+00 CTL_TRT
## Mpp7 1.142533e-01 -0.8156726 0.084 0.207 1.000000e+00 CTL_TRT
## Id3 1.160979e-01 2.4170568 0.328 0.372 1.000000e+00 CTL_TRT
## Fmnl2 1.167863e-01 1.3051945 0.406 0.392 1.000000e+00 CTL_TRT
## Nfe2l3 1.189956e-01 0.5317207 0.029 0.199 1.000000e+00 CTL_TRT
## Gatm 1.196601e-01 3.7468915 0.351 0.346 1.000000e+00 CTL_TRT
## Tox 1.204793e-01 2.7359847 0.112 0.206 1.000000e+00 CTL_TRT
## Gm26887 1.218560e-01 1.9699314 0.011 0.222 1.000000e+00 CTL_TRT
## Mdfic 1.225280e-01 1.3057448 0.058 0.163 1.000000e+00 CTL_TRT
## Erbin 1.227339e-01 0.8806697 0.176 0.232 1.000000e+00 CTL_TRT
## Trnp1 1.228590e-01 -0.7396053 0.400 0.410 1.000000e+00 CTL_TRT
## Synpr 1.260223e-01 -1.0105597 0.354 0.296 1.000000e+00 CTL_TRT
## Gpam 1.267234e-01 1.5151925 0.253 0.239 1.000000e+00 CTL_TRT
## Plscr2 1.279610e-01 -0.4048765 0.132 0.168 1.000000e+00 CTL_TRT
## Ctla2a 1.291486e-01 0.7994515 0.019 0.139 1.000000e+00 CTL_TRT
## Gm26871 1.310845e-01 1.5615707 0.289 0.252 1.000000e+00 CTL_TRT
## Phlda1 1.333147e-01 1.1340053 0.315 0.321 1.000000e+00 CTL_TRT
## Nkain2 1.378915e-01 1.3475758 0.352 0.323 1.000000e+00 CTL_TRT
## Irf1 1.382576e-01 2.1882832 0.320 0.342 1.000000e+00 CTL_TRT
## Ncam1 1.411390e-01 0.7967836 0.411 0.380 1.000000e+00 CTL_TRT
## Lrfn5 1.435607e-01 2.0592220 0.273 0.222 1.000000e+00 CTL_TRT
## Ucp2 1.436217e-01 2.9404705 0.158 0.226 1.000000e+00 CTL_TRT
## Sox2ot 1.460142e-01 1.8517480 0.200 0.280 1.000000e+00 CTL_TRT
## Osgin1 1.466308e-01 1.1668752 0.026 0.190 1.000000e+00 CTL_TRT
## Hey2 1.484938e-01 -0.8091669 0.182 0.206 1.000000e+00 CTL_TRT
## Mapk10 1.506465e-01 1.3598876 0.357 0.352 1.000000e+00 CTL_TRT
## Plekha4 1.539815e-01 0.5495207 0.211 0.304 1.000000e+00 CTL_TRT
## Car4 1.556134e-01 3.8633174 0.003 0.126 1.000000e+00 CTL_TRT
## Cd81 1.570635e-01 1.0653373 0.400 0.396 1.000000e+00 CTL_TRT
## Rgcc 1.597211e-01 1.1192178 0.335 0.347 1.000000e+00 CTL_TRT
## Plekha7 1.612680e-01 4.3185022 0.048 0.185 1.000000e+00 CTL_TRT
## Dhrs2 1.617115e-01 2.9589715 0.039 0.189 1.000000e+00 CTL_TRT
## Ctxn3 1.646249e-01 1.1458146 0.230 0.218 1.000000e+00 CTL_TRT
## Tmco4 1.696977e-01 4.1183424 0.026 0.244 1.000000e+00 CTL_TRT
## Rims2 1.705469e-01 1.0291046 0.314 0.280 1.000000e+00 CTL_TRT
## Plpp3 1.735084e-01 -1.8292629 0.230 0.306 1.000000e+00 CTL_TRT
## Ephb4 1.738346e-01 3.0121191 0.008 0.228 1.000000e+00 CTL_TRT
## Ifrd1 1.752647e-01 1.0916879 0.323 0.310 1.000000e+00 CTL_TRT
## Tsc22d4 1.752765e-01 7.6647800 0.268 0.357 1.000000e+00 CTL_TRT
## Dgkh 1.755197e-01 -2.2495046 0.392 0.383 1.000000e+00 CTL_TRT
## Gpc6 1.757092e-01 0.9371740 0.251 0.270 1.000000e+00 CTL_TRT
## Cd302 1.763893e-01 1.0809129 0.032 0.175 1.000000e+00 CTL_TRT
## Msi2 1.812617e-01 7.8112951 0.343 0.340 1.000000e+00 CTL_TRT
## Meg3 1.853034e-01 -2.7136705 0.270 0.213 1.000000e+00 CTL_TRT
## Fos 1.864328e-01 2.2710706 0.342 0.360 1.000000e+00 CTL_TRT
## Hcn1 1.877372e-01 3.5333235 0.342 0.346 1.000000e+00 CTL_TRT
## Fign 1.912042e-01 -0.4712978 0.248 0.290 1.000000e+00 CTL_TRT
## Ccrl2 1.950962e-01 2.2744880 0.007 0.182 1.000000e+00 CTL_TRT
## Ano4 1.951573e-01 1.6422356 0.180 0.151 1.000000e+00 CTL_TRT
## Dgki 1.951744e-01 2.2476177 0.252 0.216 1.000000e+00 CTL_TRT
## Ptpn14 1.969642e-01 4.8377469 0.026 0.210 1.000000e+00 CTL_TRT
## Fat3 1.971146e-01 2.2130231 0.201 0.156 1.000000e+00 CTL_TRT
## Tyrp1 1.988107e-01 3.1396776 0.063 0.149 1.000000e+00 CTL_TRT
## Ext1 2.063204e-01 -2.3539112 0.361 0.365 1.000000e+00 CTL_TRT
## Gas2l3 2.065813e-01 1.3105594 0.144 0.239 1.000000e+00 CTL_TRT
## Tcf7l2 2.068884e-01 2.0209355 0.141 0.259 1.000000e+00 CTL_TRT
## Ppic 2.087244e-01 0.3252522 0.011 0.203 1.000000e+00 CTL_TRT
## Mir99ahg 2.103889e-01 2.2559262 0.353 0.364 1.000000e+00 CTL_TRT
## Tgif2 2.109092e-01 1.9043716 0.023 0.208 1.000000e+00 CTL_TRT
## Cacna2d1 2.112240e-01 1.1275083 0.369 0.344 1.000000e+00 CTL_TRT
## Fads2 2.113702e-01 0.8010722 0.318 0.287 1.000000e+00 CTL_TRT
## Itpr3 2.135537e-01 -0.7478782 0.117 0.194 1.000000e+00 CTL_TRT
## Etv6 2.162894e-01 1.5399140 0.262 0.321 1.000000e+00 CTL_TRT
## Anxa3 2.208468e-01 0.5278116 0.014 0.141 1.000000e+00 CTL_TRT
## Chpt1 2.214760e-01 6.2113532 0.189 0.260 1.000000e+00 CTL_TRT
## Btg2 2.223691e-01 -2.5427750 0.211 0.287 1.000000e+00 CTL_TRT
## Egfl8 2.308104e-01 3.1188757 0.182 0.239 1.000000e+00 CTL_TRT
## Pam 2.316368e-01 2.4637192 0.370 0.363 1.000000e+00 CTL_TRT
## Ctnna2 2.328028e-01 2.1707186 0.273 0.231 1.000000e+00 CTL_TRT
## Lmod1 2.367537e-01 0.6938730 0.004 0.131 1.000000e+00 CTL_TRT
## Gm46212 2.370710e-01 2.1918342 0.002 0.188 1.000000e+00 CTL_TRT
## Epha5 2.376377e-01 -0.8500385 0.195 0.211 1.000000e+00 CTL_TRT
## Prkca 2.447386e-01 2.2347533 0.364 0.348 1.000000e+00 CTL_TRT
## Hes5 2.454673e-01 2.9669955 0.027 0.141 1.000000e+00 CTL_TRT
## Glul 2.456938e-01 2.1242653 0.363 0.319 1.000000e+00 CTL_TRT
## Scn8a 2.472259e-01 2.9694142 0.273 0.262 1.000000e+00 CTL_TRT
## Ntng1 2.485650e-01 1.2314198 0.143 0.165 1.000000e+00 CTL_TRT
## Chgb 2.489137e-01 1.2848360 0.255 0.260 1.000000e+00 CTL_TRT
## Celf2 2.516098e-01 0.3000783 0.417 0.389 1.000000e+00 CTL_TRT
## Adamtsl5 2.518385e-01 3.3339129 0.026 0.201 1.000000e+00 CTL_TRT
## Tmem178b 2.545755e-01 1.1446138 0.290 0.276 1.000000e+00 CTL_TRT
## Nes 2.554729e-01 3.7872800 0.033 0.182 1.000000e+00 CTL_TRT
## Serpini1 2.621722e-01 3.1169515 0.259 0.239 1.000000e+00 CTL_TRT
## Mob3b 2.636252e-01 3.6313204 0.090 0.150 1.000000e+00 CTL_TRT
## Stac2 2.636411e-01 0.4568669 0.301 0.223 1.000000e+00 CTL_TRT
## 4933413L06Rik 2.648379e-01 1.7737018 0.009 0.112 1.000000e+00 CTL_TRT
## Chl1 2.672731e-01 -0.5291640 0.349 0.339 1.000000e+00 CTL_TRT
## Fxyd1 2.678891e-01 2.5512132 0.337 0.365 1.000000e+00 CTL_TRT
## Plch1 2.701212e-01 1.1666372 0.027 0.208 1.000000e+00 CTL_TRT
## Il17b 2.703614e-01 0.2904132 0.012 0.233 1.000000e+00 CTL_TRT
## Pf4 2.781882e-01 -0.3036602 0.017 0.124 1.000000e+00 CTL_TRT
## Cpne3 2.805282e-01 -0.9403969 0.395 0.350 1.000000e+00 CTL_TRT
## Mal 2.824599e-01 -3.2398627 0.269 0.322 1.000000e+00 CTL_TRT
## Rhobtb3 2.867722e-01 2.3445534 0.154 0.201 1.000000e+00 CTL_TRT
## Gm26827 2.875101e-01 2.3140865 0.008 0.215 1.000000e+00 CTL_TRT
## Srgn 2.926928e-01 1.3325968 0.038 0.123 1.000000e+00 CTL_TRT
## Rims1 2.968017e-01 1.7895458 0.284 0.242 1.000000e+00 CTL_TRT
## Rtp4 2.971170e-01 -0.6694854 0.101 0.185 1.000000e+00 CTL_TRT
## Sox9 2.983115e-01 3.7719992 0.004 0.138 1.000000e+00 CTL_TRT
## Kcnab1 3.028231e-01 -0.3973981 0.287 0.250 1.000000e+00 CTL_TRT
## Tgm2 3.043415e-01 -0.5825073 0.009 0.190 1.000000e+00 CTL_TRT
## Dpp6 3.044600e-01 2.5648525 0.325 0.316 1.000000e+00 CTL_TRT
## Arid5b 3.049616e-01 7.0334090 0.309 0.341 1.000000e+00 CTL_TRT
## Bcan 3.059937e-01 1.9128580 0.254 0.236 1.000000e+00 CTL_TRT
## Bcl2 3.068815e-01 0.3521480 0.217 0.267 1.000000e+00 CTL_TRT
## Tcf12 3.097833e-01 1.6420779 0.296 0.324 1.000000e+00 CTL_TRT
## Rrad 3.186709e-01 1.2933639 0.013 0.146 1.000000e+00 CTL_TRT
## Edil3 3.194605e-01 0.4423796 0.356 0.342 1.000000e+00 CTL_TRT
## Nlgn1 3.195267e-01 1.2235256 0.206 0.228 1.000000e+00 CTL_TRT
## Gm17036 3.217461e-01 2.4773854 0.023 0.103 1.000000e+00 CTL_TRT
## Nrxn1 3.250617e-01 -0.4005571 0.336 0.299 1.000000e+00 CTL_TRT
## Magi3 3.253376e-01 3.3176227 0.319 0.322 1.000000e+00 CTL_TRT
## Gbp6 3.272083e-01 -1.2835337 0.051 0.169 1.000000e+00 CTL_TRT
## Olfm1 3.280932e-01 0.3041840 0.390 0.394 1.000000e+00 CTL_TRT
## Jun 3.310547e-01 4.0074656 0.371 0.395 1.000000e+00 CTL_TRT
## Ndst4 3.358244e-01 1.8580195 0.158 0.162 1.000000e+00 CTL_TRT
## Dclk1 3.414688e-01 0.3556912 0.366 0.331 1.000000e+00 CTL_TRT
## Gpx1 3.458061e-01 1.0280336 0.392 0.407 1.000000e+00 CTL_TRT
## Ptprt 3.488373e-01 1.4704104 0.367 0.352 1.000000e+00 CTL_TRT
## Slc12a2 3.499719e-01 1.1844150 0.390 0.359 1.000000e+00 CTL_TRT
## Pappa 3.531995e-01 2.8308461 0.055 0.141 1.000000e+00 CTL_TRT
## Kcnk1 3.582281e-01 1.8311816 0.164 0.196 1.000000e+00 CTL_TRT
## Miat 3.631078e-01 -0.9128004 0.252 0.194 1.000000e+00 CTL_TRT
## Thbs2 3.664547e-01 1.8402686 0.011 0.168 1.000000e+00 CTL_TRT
## Erc2 3.732902e-01 1.8855535 0.304 0.248 1.000000e+00 CTL_TRT
## Npy 3.769936e-01 2.1616961 0.002 0.131 1.000000e+00 CTL_TRT
## Qk 3.798615e-01 2.0984068 0.359 0.389 1.000000e+00 CTL_TRT
## Gpx8 3.819403e-01 2.0095859 0.080 0.184 1.000000e+00 CTL_TRT
## Slc26a2 3.849937e-01 -2.2972804 0.015 0.224 1.000000e+00 CTL_TRT
## Samd4 3.852172e-01 0.7228267 0.169 0.285 1.000000e+00 CTL_TRT
## Klhl29 3.884477e-01 1.0940071 0.257 0.221 1.000000e+00 CTL_TRT
## Aif1l 3.890653e-01 -1.4582218 0.064 0.202 1.000000e+00 CTL_TRT
## Tmtc2 3.892130e-01 6.2673304 0.346 0.357 1.000000e+00 CTL_TRT
## Calml4 3.910106e-01 1.4595651 0.090 0.184 1.000000e+00 CTL_TRT
## Fbxl7 3.942934e-01 -0.4915664 0.248 0.311 1.000000e+00 CTL_TRT
## Cadm2 3.979705e-01 1.1946952 0.278 0.267 1.000000e+00 CTL_TRT
## Gm45680 3.986548e-01 2.4507962 0.003 0.172 1.000000e+00 CTL_TRT
## Rgs4 3.994415e-01 0.3207724 0.377 0.385 1.000000e+00 CTL_TRT
## Stk17b 4.020016e-01 0.5397960 0.026 0.202 1.000000e+00 CTL_TRT
## Pros1 4.023586e-01 1.8872413 0.098 0.197 1.000000e+00 CTL_TRT
## A830082K12Rik 4.077751e-01 2.0194472 0.033 0.203 1.000000e+00 CTL_TRT
## Acpp 4.079878e-01 -3.0269906 0.372 0.309 1.000000e+00 CTL_TRT
## Ccn1 4.103060e-01 1.8445381 0.243 0.221 1.000000e+00 CTL_TRT
## Fhod3 4.114305e-01 4.2009394 0.072 0.172 1.000000e+00 CTL_TRT
## Ttf1 4.182749e-01 3.7612272 0.045 0.208 1.000000e+00 CTL_TRT
## Phldb2 4.229830e-01 -0.7132967 0.074 0.188 1.000000e+00 CTL_TRT
## Ctsb 4.251834e-01 1.2998479 0.396 0.392 1.000000e+00 CTL_TRT
## Gpr37l1 4.264901e-01 3.3765621 0.259 0.240 1.000000e+00 CTL_TRT
## Prss35 4.326661e-01 0.8137449 0.125 0.201 1.000000e+00 CTL_TRT
## Ms4a6b 4.339909e-01 2.0893647 0.006 0.115 1.000000e+00 CTL_TRT
## Robo2 4.368835e-01 1.1956230 0.330 0.285 1.000000e+00 CTL_TRT
## Prkcq 4.396260e-01 -0.2980346 0.166 0.177 1.000000e+00 CTL_TRT
## Cxcl12 4.417242e-01 2.4602352 0.020 0.125 1.000000e+00 CTL_TRT
## Fyb 4.466644e-01 0.3919559 0.022 0.203 1.000000e+00 CTL_TRT
## Fmo1 4.585098e-01 0.7035917 0.172 0.180 1.000000e+00 CTL_TRT
## Gfra2 4.604780e-01 -0.8299259 0.295 0.230 1.000000e+00 CTL_TRT
## Sik3 4.691019e-01 -3.0858802 0.176 0.269 1.000000e+00 CTL_TRT
## Pou3f2 4.703213e-01 3.8045301 0.063 0.190 1.000000e+00 CTL_TRT
## Postn 4.734777e-01 1.3949056 0.119 0.153 1.000000e+00 CTL_TRT
## Nrg3 4.740228e-01 1.5827824 0.261 0.209 1.000000e+00 CTL_TRT
## Gm7271 4.787566e-01 3.4860441 0.159 0.137 1.000000e+00 CTL_TRT
## Cd63 4.790846e-01 5.2758176 0.377 0.391 1.000000e+00 CTL_TRT
## Dag1 4.806132e-01 -0.3800781 0.305 0.344 1.000000e+00 CTL_TRT
## Ecscr 4.849725e-01 0.6927736 0.019 0.184 1.000000e+00 CTL_TRT
## mt-Nd1 4.867853e-01 0.3035589 0.447 0.466 1.000000e+00 CTL_TRT
## 2310022B05Rik 4.885448e-01 2.3665732 0.161 0.189 1.000000e+00 CTL_TRT
## Pbx1 4.891147e-01 -0.8131801 0.268 0.283 1.000000e+00 CTL_TRT
## Nid1 4.922923e-01 3.4090509 0.132 0.195 1.000000e+00 CTL_TRT
## Rere 4.928022e-01 2.7031099 0.371 0.374 1.000000e+00 CTL_TRT
## Fgf12 5.027824e-01 0.6027026 0.297 0.277 1.000000e+00 CTL_TRT
## Slc27a1 5.054028e-01 -0.3683221 0.200 0.223 1.000000e+00 CTL_TRT
## Kctd16 5.078770e-01 1.8475380 0.290 0.252 1.000000e+00 CTL_TRT
## Slc2a10 5.084668e-01 1.8044855 0.002 0.112 1.000000e+00 CTL_TRT
## Sorbs2 5.097772e-01 1.6620274 0.256 0.283 1.000000e+00 CTL_TRT
## Baz2b 5.159239e-01 2.8843901 0.335 0.344 1.000000e+00 CTL_TRT
## Cd55 5.232521e-01 1.0871302 0.364 0.331 1.000000e+00 CTL_TRT
## Gm15541 5.255828e-01 0.3320895 0.001 0.143 1.000000e+00 CTL_TRT
## Aldoc 5.275359e-01 1.5682284 0.364 0.320 1.000000e+00 CTL_TRT
## Rab27b 5.304657e-01 0.3791829 0.261 0.215 1.000000e+00 CTL_TRT
## Mlip 5.312853e-01 -1.4259568 0.081 0.193 1.000000e+00 CTL_TRT
## Egr1 5.371306e-01 2.2187879 0.342 0.349 1.000000e+00 CTL_TRT
## Nav2 5.410726e-01 0.6735023 0.269 0.293 1.000000e+00 CTL_TRT
## Nsg1 5.438428e-01 4.1289603 0.231 0.249 1.000000e+00 CTL_TRT
## Cntn1 5.483892e-01 1.0474202 0.355 0.325 1.000000e+00 CTL_TRT
## Frmd4a 5.507314e-01 1.6585055 0.330 0.313 1.000000e+00 CTL_TRT
## Cecr2 5.525486e-01 3.6262766 0.043 0.200 1.000000e+00 CTL_TRT
## Gm26759 5.529074e-01 4.7858786 0.005 0.217 1.000000e+00 CTL_TRT
## Ehbp1 5.539735e-01 -0.7467857 0.310 0.307 1.000000e+00 CTL_TRT
## Grik1 5.568176e-01 1.1677888 0.256 0.219 1.000000e+00 CTL_TRT
## C1s1 5.578651e-01 2.7993738 0.008 0.192 1.000000e+00 CTL_TRT
## Fosb 5.621151e-01 2.2009910 0.363 0.356 1.000000e+00 CTL_TRT
## D130009I18Rik 5.634739e-01 2.5810462 0.258 0.211 1.000000e+00 CTL_TRT
## Sorcs1 5.651579e-01 1.1365672 0.339 0.343 1.000000e+00 CTL_TRT
## Lmo4 5.744601e-01 0.5276680 0.262 0.331 1.000000e+00 CTL_TRT
## Abi3bp 5.759626e-01 3.1473563 0.058 0.156 1.000000e+00 CTL_TRT
## Ezr 5.790267e-01 -2.7828364 0.173 0.228 1.000000e+00 CTL_TRT
## Sema6a 5.798314e-01 3.9566338 0.169 0.248 1.000000e+00 CTL_TRT
## Elmo1 5.803766e-01 1.5555574 0.238 0.268 1.000000e+00 CTL_TRT
## Sparc 5.929420e-01 2.8286489 0.356 0.377 1.000000e+00 CTL_TRT
## Anks1b 5.945782e-01 1.0994523 0.328 0.286 1.000000e+00 CTL_TRT
## Scarf2 5.956415e-01 1.0692668 0.004 0.137 1.000000e+00 CTL_TRT
## Cebpd 5.999724e-01 2.2069044 0.306 0.330 1.000000e+00 CTL_TRT
## Emilin2 6.014939e-01 0.8790426 0.002 0.102 1.000000e+00 CTL_TRT
## Cd164 6.025830e-01 3.9773430 0.304 0.300 1.000000e+00 CTL_TRT
## Hhex 6.062244e-01 2.1310685 0.002 0.105 1.000000e+00 CTL_TRT
## Csmd2 6.080790e-01 3.7399394 0.270 0.239 1.000000e+00 CTL_TRT
## Mmrn2 6.096444e-01 1.3912031 0.015 0.175 1.000000e+00 CTL_TRT
## Snhg14 6.096646e-01 1.1738289 0.268 0.204 1.000000e+00 CTL_TRT
## Car10 6.216099e-01 1.0000891 0.256 0.198 1.000000e+00 CTL_TRT
## Bmp2 6.225049e-01 2.0289737 0.007 0.114 1.000000e+00 CTL_TRT
## St6galnac3 6.255645e-01 3.3030292 0.249 0.202 1.000000e+00 CTL_TRT
## Npas3 6.255878e-01 3.9826654 0.184 0.227 1.000000e+00 CTL_TRT
## Gm45904 6.281649e-01 3.3192590 0.005 0.104 1.000000e+00 CTL_TRT
## Birc3 6.284987e-01 1.0662389 0.029 0.167 1.000000e+00 CTL_TRT
## Lyg2 6.285543e-01 3.5082022 0.005 0.177 1.000000e+00 CTL_TRT
## Sparcl1 6.375603e-01 2.2662908 0.363 0.369 1.000000e+00 CTL_TRT
## Igtp 6.408637e-01 1.8441026 0.121 0.193 1.000000e+00 CTL_TRT
## Grm7 6.413273e-01 2.3320288 0.295 0.270 1.000000e+00 CTL_TRT
## Lpar1 6.429615e-01 1.2301635 0.317 0.336 1.000000e+00 CTL_TRT
## Anxa5 6.444790e-01 4.5582338 0.414 0.409 1.000000e+00 CTL_TRT
## Vcam1 6.551189e-01 1.9187460 0.024 0.180 1.000000e+00 CTL_TRT
## Nfkbiz 6.573461e-01 -0.2655740 0.161 0.226 1.000000e+00 CTL_TRT
## Grid1 6.575072e-01 2.2301856 0.120 0.195 1.000000e+00 CTL_TRT
## Lama2 6.667562e-01 0.7399607 0.200 0.290 1.000000e+00 CTL_TRT
## Slc9a9 6.698135e-01 1.9945266 0.339 0.309 1.000000e+00 CTL_TRT
## Col5a1 6.784832e-01 1.2316592 0.019 0.235 1.000000e+00 CTL_TRT
## Irs1 6.882161e-01 -3.3216079 0.068 0.182 1.000000e+00 CTL_TRT
## Akap6 6.885836e-01 0.2654426 0.390 0.379 1.000000e+00 CTL_TRT
## Smtn 6.888176e-01 3.1151012 0.058 0.180 1.000000e+00 CTL_TRT
## Pde4b 6.889209e-01 0.4694873 0.291 0.271 1.000000e+00 CTL_TRT
## Gng5 6.940113e-01 0.5036860 0.414 0.411 1.000000e+00 CTL_TRT
## Adam12 6.957732e-01 2.2318923 0.023 0.196 1.000000e+00 CTL_TRT
## Rbpms2 6.992653e-01 2.4202746 0.009 0.256 1.000000e+00 CTL_TRT
## Sv2b 7.042886e-01 0.4032420 0.270 0.254 1.000000e+00 CTL_TRT
## Zfp703 7.168292e-01 1.4196585 0.231 0.248 1.000000e+00 CTL_TRT
## Plscr1 7.217144e-01 0.6169827 0.070 0.159 1.000000e+00 CTL_TRT
## Tagln 7.237422e-01 0.3613499 0.039 0.129 1.000000e+00 CTL_TRT
## Rbfox1 7.346280e-01 0.9437382 0.295 0.255 1.000000e+00 CTL_TRT
## Trpc3 7.418663e-01 2.7199381 0.246 0.186 1.000000e+00 CTL_TRT
## Scn7a 7.474483e-01 0.4755955 0.384 0.361 1.000000e+00 CTL_TRT
## Maf 7.545135e-01 1.5338606 0.359 0.362 1.000000e+00 CTL_TRT
## Slc35f1 7.610523e-01 2.8885774 0.335 0.326 1.000000e+00 CTL_TRT
## Macrod2 7.675357e-01 0.9223511 0.297 0.280 1.000000e+00 CTL_TRT
## Asic2 7.823059e-01 1.4883774 0.289 0.249 1.000000e+00 CTL_TRT
## Wls 7.834279e-01 0.4420802 0.178 0.208 1.000000e+00 CTL_TRT
## Ccl3 7.845693e-01 2.2907381 0.010 0.106 1.000000e+00 CTL_TRT
## Fndc3b 7.990253e-01 0.4919720 0.181 0.279 1.000000e+00 CTL_TRT
## Igfbp6 8.004406e-01 -1.2914419 0.038 0.127 1.000000e+00 CTL_TRT
## Ptprn 8.056710e-01 0.4903697 0.371 0.393 1.000000e+00 CTL_TRT
## Ccl5 8.091799e-01 0.7206346 0.005 0.150 1.000000e+00 CTL_TRT
## Selenow 8.213493e-01 2.5224454 0.452 0.429 1.000000e+00 CTL_TRT
## Klf5 8.272045e-01 1.5229577 0.178 0.205 1.000000e+00 CTL_TRT
## Cplx2 8.274360e-01 2.2639188 0.226 0.266 1.000000e+00 CTL_TRT
## Grip1 8.289729e-01 2.5688572 0.311 0.268 1.000000e+00 CTL_TRT
## Cdk19 8.355719e-01 0.4111628 0.239 0.307 1.000000e+00 CTL_TRT
## Prdm16os 8.386145e-01 2.2368421 0.022 0.216 1.000000e+00 CTL_TRT
## Plscr4 8.457341e-01 0.8894342 0.117 0.202 1.000000e+00 CTL_TRT
## Megf10 8.466516e-01 0.8865192 0.135 0.184 1.000000e+00 CTL_TRT
## Gprc5b 8.478279e-01 0.3335520 0.113 0.178 1.000000e+00 CTL_TRT
## Sod3 8.491468e-01 1.6102089 0.045 0.180 1.000000e+00 CTL_TRT
## Gm20275 8.506471e-01 1.2145529 0.054 0.169 1.000000e+00 CTL_TRT
## Stmn2 8.516402e-01 0.4710962 0.453 0.450 1.000000e+00 CTL_TRT
## Adamts12 8.568807e-01 0.5687797 0.012 0.176 1.000000e+00 CTL_TRT
## mt-Co3 8.577327e-01 -0.3863748 0.460 0.475 1.000000e+00 CTL_TRT
## Hmgn1 8.580663e-01 0.6142480 0.297 0.344 1.000000e+00 CTL_TRT
## Scn1a 8.612295e-01 1.6233790 0.229 0.242 1.000000e+00 CTL_TRT
## Zfp36l1 8.621147e-01 0.7618221 0.252 0.315 1.000000e+00 CTL_TRT
## Col1a1 8.629190e-01 1.7224336 0.032 0.136 1.000000e+00 CTL_TRT
## Rasal2 8.645117e-01 2.1316085 0.259 0.298 1.000000e+00 CTL_TRT
## Arhgap42 8.649595e-01 -4.9230003 0.159 0.220 1.000000e+00 CTL_TRT
## Plekhf1 8.713657e-01 1.7086870 0.043 0.171 1.000000e+00 CTL_TRT
## Selenbp1 8.748305e-01 1.8724638 0.004 0.221 1.000000e+00 CTL_TRT
## Lhfp 8.771200e-01 1.9444240 0.265 0.302 1.000000e+00 CTL_TRT
## Kctd8 8.831544e-01 4.1034421 0.307 0.273 1.000000e+00 CTL_TRT
## Reep5 8.835876e-01 1.7957987 0.396 0.396 1.000000e+00 CTL_TRT
## Atp1a2 8.887946e-01 3.2277844 0.338 0.344 1.000000e+00 CTL_TRT
## Lcorl 8.889804e-01 5.2160687 0.245 0.247 1.000000e+00 CTL_TRT
## Mdga2 8.893455e-01 1.7943586 0.327 0.299 1.000000e+00 CTL_TRT
## Cldn1 8.918565e-01 2.8019622 0.010 0.202 1.000000e+00 CTL_TRT
## mt-Cytb 8.929852e-01 -0.4276666 0.473 0.472 1.000000e+00 CTL_TRT
## Prkg1 8.933538e-01 0.7336163 0.305 0.266 1.000000e+00 CTL_TRT
## Klhl5 9.000458e-01 -2.5666237 0.275 0.231 1.000000e+00 CTL_TRT
## Kcnh8 9.055974e-01 2.6181873 0.125 0.237 1.000000e+00 CTL_TRT
## Vsnl1 9.077487e-01 0.5815220 0.202 0.253 1.000000e+00 CTL_TRT
## Limch1 9.101231e-01 -3.1620028 0.188 0.299 1.000000e+00 CTL_TRT
## Dlgap1 9.104143e-01 2.0979172 0.358 0.364 1.000000e+00 CTL_TRT
## Jcad 9.119028e-01 3.4409655 0.033 0.176 1.000000e+00 CTL_TRT
## Epas1 9.173821e-01 1.0845320 0.286 0.269 1.000000e+00 CTL_TRT
## Cspg4 9.204835e-01 0.3018929 0.016 0.234 1.000000e+00 CTL_TRT
## Frmd6 9.236779e-01 1.6457013 0.178 0.239 1.000000e+00 CTL_TRT
## Calm2 9.274964e-01 1.4093595 0.439 0.420 1.000000e+00 CTL_TRT
## Oxr1 9.283357e-01 -1.0440200 0.361 0.344 1.000000e+00 CTL_TRT
## Zfp608 9.473907e-01 0.6710528 0.340 0.336 1.000000e+00 CTL_TRT
## Kcnip4 9.497987e-01 0.8259095 0.240 0.206 1.000000e+00 CTL_TRT
## Fam181b 9.556646e-01 3.6226654 0.074 0.180 1.000000e+00 CTL_TRT
## Col6a1 9.614738e-01 0.9841771 0.017 0.127 1.000000e+00 CTL_TRT
## Klf6 9.692125e-01 0.4774479 0.359 0.352 1.000000e+00 CTL_TRT
## Atf3 9.728939e-01 -0.8738357 0.348 0.385 1.000000e+00 CTL_TRT
## Ankrd28 9.758255e-01 -1.2686690 0.276 0.295 1.000000e+00 CTL_TRT
## Ly6a 9.787805e-01 -0.7103589 0.030 0.120 1.000000e+00 CTL_TRT
## Arih1 9.808308e-01 -1.3649990 0.374 0.396 1.000000e+00 CTL_TRT
## Zfp385b 9.823480e-01 2.3339245 0.240 0.204 1.000000e+00 CTL_TRT
## Igsf11 9.941353e-01 -0.5749539 0.094 0.192 1.000000e+00 CTL_TRTDifferential expression Analysis for cluster between groups
Next we will do DEG for each cluster betweent the two groups, and write the results to a csv file
Quatitative analysis of DEGs by each cluster
MAPK pathway gene plotting
visualize using ShinnyCell
Neha and Jessical, you can ignore these two chunks for shinny visualization if knit to html, but make sure to try it on your local machine
For Chris Plaisier analysis
#library(ShinyCell)
#setwd("D:/Bioinformatics Projects/sc_exp2/Chris_Plaisier_analysis")
# getExampleData() # Download example dataset (~200 MB) no need to run this if you run it before, with the .rds file in working directory
#seurat_integrated = readRDS("seurat_integrated_w_extras.RDS")
#scConf = createConfig(seurat_integrated)
#makeShinyApp(seurat_integrated, scConf, gene.mapping = TRUE,
# shiny.title = "four sample_two brain groups")
# rm(list = ls())
# rm(list = setdiff(ls(), "seurat_integrated"))
#setwd("D:/Bioinformatics Projects/sc_exp2/Chris_Plaisier_analysis/shinyApp") # verify change of dir in console using getwd()
#shiny::runApp() # after you run this App, another R will be open, maximize it, then select and plot and test the graphic output. While this R window is open, the > ready in console will NOT be ready. You can also select output to browser. In order for the browser to work, you need to keep this new R window open. If you close the R window, the brower will gray out.