report

Descrittive

Tabella descrittiva con le caratteristiche dei pazienti sulla base del trattamento : chirurgia radicale (2) vs chirurgia palliativa (1) vs sola osservazione (0).

Characteristic	Overall, N = 1201	Trattamento			p-value2
		0, N = 421	1, N = 351	2, N = 431
eta_alla_diagnosi	90.00 (90.00, 92.00)	91.00 (90.00, 94.00)	90.00 (90.00, 91.50)	90.00 (90.00, 91.00)	0.009
Unknown	1	1	0	0
karnofski_alla_diagnosi	80 (70, 80)	70 (60, 80)	80 (65, 90)	80 (70, 90)	0.007
Unknown	1	1	0	0
ecog_alla_diagnosi					0.011
0	18 (15%)	2 (4.9%)	9 (26%)	7 (16%)
1	44 (37%)	11 (27%)	12 (34%)	21 (49%)
2	39 (33%)	16 (39%)	10 (29%)	13 (30%)
3	16 (13%)	11 (27%)	3 (8.6%)	2 (4.7%)
4	2 (1.7%)	1 (2.4%)	1 (2.9%)	0 (0%)
Unknown	1	1	0	0
charlson_score
0	27 (23%)	8 (19%)	9 (26%)	10 (24%)
1	31 (26%)	7 (17%)	10 (29%)	14 (33%)
2	25 (21%)	10 (24%)	6 (17%)	9 (21%)
3	22 (18%)	9 (21%)	5 (14%)	8 (19%)
4	7 (5.9%)	4 (9.5%)	2 (5.7%)	1 (2.4%)
5	2 (1.7%)	2 (4.8%)	0 (0%)	0 (0%)
6	3 (2.5%)	0 (0%)	3 (8.6%)	0 (0%)
7	2 (1.7%)	2 (4.8%)	0 (0%)	0 (0%)
Unknown	1	0	0	1
pregresse_neoplasie					0.9
0	90 (75%)	34 (81%)	26 (74%)	30 (70%)
1	9 (7.5%)	2 (4.8%)	2 (5.7%)	5 (12%)
2	12 (10%)	3 (7.1%)	4 (11%)	5 (12%)
3	9 (7.5%)	3 (7.1%)	3 (8.6%)	3 (7.0%)
mini_mental_state_examination	30.0 (26.8, 30.0)	29.0 (24.2, 30.0)	30.0 (27.0, 30.0)	30.0 (28.0, 30.0)	0.052
geriatric_depression_scale	0 (0, 10)	6 (0, 12)	0 (0, 9)	0 (0, 5)	0.031
peso	67 (58, 76)	68 (58, 77)	68 (57, 76)	67 (60, 74)	>0.9
altezza	163.0 (160.0, 167.0)	163.0 (158.2, 167.0)	163.0 (161.0, 169.0)	163.0 (161.0, 164.5)	0.6
bmi	26.0 (21.0, 28.2)	26.5 (21.0, 29.0)	25.0 (20.5, 29.5)	26.0 (22.0, 28.0)	0.9
familiarita					0.3
0	98 (82%)	34 (81%)	28 (80%)	36 (84%)
1	7 (5.8%)	4 (9.5%)	3 (8.6%)	0 (0%)
2	15 (12%)	4 (9.5%)	4 (11%)	7 (16%)
lato					0.3
0	52 (44%)	13 (32%)	16 (46%)	23 (53%)
1	62 (52%)	25 (61%)	18 (51%)	19 (44%)
2	5 (4.2%)	3 (7.3%)	1 (2.9%)	1 (2.3%)
Unknown	1	1	0	0
sede					0.7
0	93 (78%)	31 (76%)	26 (74%)	36 (84%)
1	2 (1.7%)	0 (0%)	2 (5.7%)	0 (0%)
2	6 (5.0%)	2 (4.9%)	1 (2.9%)	3 (7.0%)
3	7 (5.9%)	3 (7.3%)	3 (8.6%)	1 (2.3%)
4	10 (8.4%)	4 (9.8%)	3 (8.6%)	3 (7.0%)
5	1 (0.8%)	1 (2.4%)	0 (0%)	0 (0%)
Unknown	1	1	0	0
palpabilita_mammaria					0.8
0	3 (2.5%)	1 (2.4%)	0 (0%)	2 (4.8%)
1	115 (97%)	40 (98%)	35 (100%)	40 (95%)
Unknown	2	1	0	1
palpabilita_linfonodale_ascellare					<0.001
0	87 (73%)	22 (54%)	33 (94%)	32 (74%)
1	32 (27%)	19 (46%)	2 (5.7%)	11 (26%)
Unknown	1	1	0	0
alterazioni_morfologiche_evidenti					0.13
0	83 (70%)	22 (54%)	28 (80%)	33 (77%)
1	18 (15%)	8 (20%)	5 (14%)	5 (12%)
2	5 (4.2%)	3 (7.3%)	1 (2.9%)	1 (2.3%)
3	13 (11%)	8 (20%)	1 (2.9%)	4 (9.3%)
Unknown	1	1	0	0
rmn_mammaria					0.064
0	112 (93%)	42 (100%)	32 (91%)	38 (88%)
1	8 (6.7%)	0 (0%)	3 (8.6%)	5 (12%)
tc					0.11
0	85 (71%)	25 (61%)	29 (83%)	31 (72%)
1	34 (29%)	16 (39%)	6 (17%)	12 (28%)
Unknown	1	1	0	0
pet_tc					0.10
0	112 (94%)	36 (88%)	35 (100%)	41 (95%)
1	7 (5.9%)	5 (12%)	0 (0%)	2 (4.7%)
Unknown	1	1	0	0
scintigrafia_ossea					0.091
0	111 (94%)	36 (88%)	35 (100%)	40 (95%)
1	7 (5.9%)	5 (12%)	0 (0%)	2 (4.8%)
Unknown	2	1	0	1
biopsia_linfonodo					0.067
0	104 (87%)	33 (80%)	34 (97%)	37 (86%)
1	15 (13%)	8 (20%)	1 (2.9%)	6 (14%)
Unknown	1	1	0	0
meta_diagnosi					0.067
1	105 (88%)	34 (81%)	34 (97%)	37 (86%)
2	15 (12%)	8 (19%)	1 (2.9%)	6 (14%)
n					0.001
0	84 (71%)	24 (59%)	33 (94%)	27 (63%)
1	35 (29%)	17 (41%)	2 (5.7%)	16 (37%)
Unknown	1	1	0	0
m					0.060
0	109 (92%)	34 (83%)	34 (97%)	41 (95%)
1	10 (8.4%)	7 (17%)	1 (2.9%)	2 (4.7%)
Unknown	1	1	0	0
grade					0.033
1	10 (8.8%)	0 (0%)	6 (19%)	4 (9.8%)
2	61 (54%)	27 (66%)	13 (42%)	21 (51%)
3	42 (37%)	14 (34%)	12 (39%)	16 (39%)
Unknown	7	1	4	2
mib1_43	20 (15, 30)	20 (14, 31)	20 (11, 25)	20 (15, 35)	0.5
Unknown	8	2	4	2
er_44	90 (85, 96)	90 (90, 100)	90 (89, 100)	90 (80, 90)	0.2
Unknown	4	1	3	0
pr_45	70 (5, 90)	80 (35, 90)	74 (5, 86)	35 (2, 80)	0.11
Unknown	4	1	3	0
her2					0.6
0	40 (35%)	11 (28%)	12 (39%)	17 (40%)
1	53 (46%)	23 (57%)	12 (39%)	18 (42%)
2	17 (15%)	4 (10%)	6 (19%)	7 (16%)
3	4 (3.5%)	2 (5.0%)	1 (3.2%)	1 (2.3%)
Unknown	6	2	4	0
stadio
IA	19 (16%)	1 (2.4%)	15 (43%)	3 (7.0%)
IC	1 (0.8%)	0 (0%)	0 (0%)	1 (2.3%)
IIA	49 (41%)	19 (45%)	13 (37%)	17 (40%)
IIB	19 (16%)	7 (17%)	2 (5.7%)	10 (23%)
IIIA	7 (5.8%)	2 (4.8%)	1 (2.9%)	4 (9.3%)
IIIB	12 (10%)	5 (12%)	2 (5.7%)	5 (12%)
IIIC	3 (2.5%)	1 (2.4%)	1 (2.9%)	1 (2.3%)
IV	10 (8.3%)	7 (17%)	1 (2.9%)	2 (4.7%)
ormonoterapia_neoadiuvante					<0.001
0	69 (57%)	4 (9.5%)	31 (89%)	34 (79%)
1	51 (42%)	38 (90%)	4 (11%)	9 (21%)
1 Median (IQR); n (%)
2 Kruskal-Wallis rank sum test; Fisher's exact test; Pearson's Chi-squared test

Trattamento

Tabella descrittiva con le caratteristiche del trattamento, post-operatorie e degli outcome, sulla base della tipologia di intervento chirurgico: chirurgia palliativa (1) vs chirurgia radicale con o senza svuotamento del cavo ascellare (0)

Characteristic	Overall, N = 781	Trattamento		p-value2
		0, N = 431	1, N = 351
bls				<0.001
0	62 (79%)	27 (63%)	35 (100%)
1	16 (21%)	16 (37%)	0 (0%)
n_sentinella				<0.001
0	63 (81%)	28 (65%)	35 (100%)
1	11 (14%)	11 (26%)	0 (0%)
2	3 (3.8%)	3 (7.0%)	0 (0%)
4	1 (1.3%)	1 (2.3%)	0 (0%)
estemporanea				0.007
0	70 (90%)	35 (81%)	35 (100%)
1	8 (10%)	8 (19%)	0 (0%)
linfoadenectomia				<0.001
0	49 (63%)	14 (33%)	35 (100%)
1	29 (37%)	29 (67%)	0 (0%)
chirurgia_ascellare				<0.001
0	21 (40%)	0 (0%)	21 (100%)
1	31 (58%)	31 (97%)	0 (0%)
2	1 (1.9%)	1 (3.1%)	0 (0%)
Unknown	25	11	14
chirurgia_palliativa				<0.001
0	43 (55%)	43 (100%)	0 (0%)
1	35 (45%)	0 (0%)	35 (100%)
istotipo_specimen				0.2
0	54 (69%)	31 (72%)	23 (66%)
0+1	1 (1.3%)	1 (2.3%)	0 (0%)
1	12 (15%)	8 (19%)	4 (11%)
1+3	1 (1.3%)	0 (0%)	1 (2.9%)
2	1 (1.3%)	0 (0%)	1 (2.9%)
4	3 (3.8%)	0 (0%)	3 (8.6%)
5	6 (7.7%)	3 (7.0%)	3 (8.6%)
concordanza				0.5
0	10 (14%)	7 (17%)	3 (9.1%)
1	64 (86%)	34 (83%)	30 (91%)
Unknown	4	2	2
margini				0.2
0	58 (74%)	35 (81%)	23 (66%)
1	11 (14%)	5 (12%)	6 (17%)
2	9 (12%)	3 (7.0%)	6 (17%)
multiplo_74				0.7
0	72 (92%)	39 (91%)	33 (94%)
1	6 (7.7%)	4 (9.3%)	2 (5.7%)
necrosi				0.7
0	72 (92%)	39 (91%)	33 (94%)
1	6 (7.7%)	4 (9.3%)	2 (5.7%)
invasione_vascolare				0.4
0	43 (55%)	22 (51%)	21 (60%)
1	35 (45%)	21 (49%)	14 (40%)
n_sent_tot				<0.001
0	64 (82%)	29 (67%)	35 (100%)
1	9 (12%)	9 (21%)	0 (0%)
2	3 (3.8%)	3 (7.0%)	0 (0%)
3	1 (1.3%)	1 (2.3%)	0 (0%)
4	1 (1.3%)	1 (2.3%)	0 (0%)
n_non_sent_tot				<0.001
0	52 (67%)	17 (40%)	35 (100%)
10	2 (2.6%)	2 (4.7%)	0 (0%)
12	2 (2.6%)	2 (4.7%)	0 (0%)
15	1 (1.3%)	1 (2.3%)	0 (0%)
16	2 (2.6%)	2 (4.7%)	0 (0%)
17	2 (2.6%)	2 (4.7%)	0 (0%)
2	2 (2.6%)	2 (4.7%)	0 (0%)
21	1 (1.3%)	1 (2.3%)	0 (0%)
3	1 (1.3%)	1 (2.3%)	0 (0%)
4	2 (2.6%)	2 (4.7%)	0 (0%)
5	4 (5.1%)	4 (9.3%)	0 (0%)
6	2 (2.6%)	2 (4.7%)	0 (0%)
7	1 (1.3%)	1 (2.3%)	0 (0%)
8	3 (3.8%)	3 (7.0%)	0 (0%)
9	1 (1.3%)	1 (2.3%)	0 (0%)
n_non_sent_pos				<0.001
0	58 (75%)	23 (55%)	35 (100%)
1	5 (6.5%)	5 (12%)	0 (0%)
12	1 (1.3%)	1 (2.4%)	0 (0%)
2	6 (7.8%)	6 (14%)	0 (0%)
3	1 (1.3%)	1 (2.4%)	0 (0%)
4	3 (3.9%)	3 (7.1%)	0 (0%)
6	2 (2.6%)	2 (4.8%)	0 (0%)
7	1 (1.3%)	1 (2.4%)	0 (0%)
Unknown	1	1	0
t				0.044
--	0 (0%)	0 (0%)	0 (0%)
02-feb	1 (1.3%)	1 (2.3%)	0 (0%)
1A 1B	1 (1.3%)	0 (0%)	1 (2.9%)
1B	3 (3.8%)	2 (4.7%)	1 (2.9%)
1BM	2 (2.6%)	1 (2.3%)	1 (2.9%)
1BM,IS	1 (1.3%)	0 (0%)	1 (2.9%)
1C	14 (18%)	3 (7.0%)	11 (31%)
1C(M)	1 (1.3%)	1 (2.3%)	0 (0%)
1CM	1 (1.3%)	1 (2.3%)	0 (0%)
2	35 (45%)	21 (49%)	14 (40%)
2 M	1 (1.3%)	1 (2.3%)	0 (0%)
2IS	1 (1.3%)	1 (2.3%)	0 (0%)
3	5 (6.4%)	5 (12%)	0 (0%)
3MIS	1 (1.3%)	0 (0%)	1 (2.9%)
4	1 (1.3%)	1 (2.3%)	0 (0%)
4B	5 (6.4%)	3 (7.0%)	2 (5.7%)
4B(M)	2 (2.6%)	1 (2.3%)	1 (2.9%)
4c(is)	1 (1.3%)	0 (0%)	1 (2.9%)
IS	1 (1.3%)	0 (0%)	1 (2.9%)
T4B	1 (1.3%)	1 (2.3%)	0 (0%)
n_2				<0.001
0	19 (24%)	17 (40%)	2 (5.7%)
0 (SN)	1 (1.3%)	1 (2.3%)	0 (0%)
1	1 (1.3%)	1 (2.3%)	0 (0%)
1a	1 (1.3%)	1 (2.3%)	0 (0%)
1A	9 (12%)	8 (19%)	1 (2.9%)
1A SN	1 (1.3%)	1 (2.3%)	0 (0%)
2	2 (2.6%)	2 (4.7%)	0 (0%)
2A	5 (6.4%)	5 (12%)	0 (0%)
3A	2 (2.6%)	2 (4.7%)	0 (0%)
N1A	1 (1.3%)	1 (2.3%)	0 (0%)
X	36 (46%)	4 (9.3%)	32 (91%)
pr_88				>0.9
0	19 (24%)	10 (23%)	9 (26%)
0/80	1 (1.3%)	0 (0%)	1 (2.9%)
10	2 (2.6%)	1 (2.3%)	1 (2.9%)
10 / 0	1 (1.3%)	1 (2.3%)	0 (0%)
100	12 (15%)	6 (14%)	6 (17%)
15	1 (1.3%)	1 (2.3%)	0 (0%)
18 / 15	1 (1.3%)	1 (2.3%)	0 (0%)
3	1 (1.3%)	1 (2.3%)	0 (0%)
30	2 (2.6%)	1 (2.3%)	1 (2.9%)
35	2 (2.6%)	1 (2.3%)	1 (2.9%)
40	2 (2.6%)	1 (2.3%)	1 (2.9%)
48	1 (1.3%)	1 (2.3%)	0 (0%)
5	5 (6.4%)	3 (7.0%)	2 (5.7%)
50	3 (3.8%)	1 (2.3%)	2 (5.7%)
60	2 (2.6%)	1 (2.3%)	1 (2.9%)
68	1 (1.3%)	1 (2.3%)	0 (0%)
70	2 (2.6%)	1 (2.3%)	1 (2.9%)
75 / 90 / 80 / 85	1 (1.3%)	1 (2.3%)	0 (0%)
78	1 (1.3%)	0 (0%)	1 (2.9%)
80	4 (5.1%)	3 (7.0%)	1 (2.9%)
85	2 (2.6%)	0 (0%)	2 (5.7%)
90	9 (12%)	6 (14%)	3 (8.6%)
95	2 (2.6%)	1 (2.3%)	1 (2.9%)
98	1 (1.3%)	0 (0%)	1 (2.9%)
erb				0.9
0	30 (39%)	16 (37%)	14 (41%)
0 / 1	1 (1.3%)	0 (0%)	1 (2.9%)
01-gen	3 (3.9%)	2 (4.7%)	1 (2.9%)
1	33 (43%)	20 (47%)	13 (38%)
1 / 1 / 1 / 1	1 (1.3%)	1 (2.3%)	0 (0%)
2	6 (7.8%)	3 (7.0%)	3 (8.8%)
3	3 (3.9%)	1 (2.3%)	2 (5.9%)
Unknown	1	0	1
complicanze				0.033
0	53 (74%)	24 (63%)	29 (85%)
1	19 (26%)	14 (37%)	5 (15%)
Unknown	6	5	1
radioterapia_adiuvante	7 (9.0%)	6 (14%)	1 (2.9%)	0.12
presenza_di_recidiva	9 (12%)	6 (14%)	3 (8.6%)	0.5
rec_locale				>0.9
0	69 (91%)	37 (90%)	32 (91%)
1	7 (9.2%)	4 (9.8%)	3 (8.6%)
Unknown	2	2	0
recidiva_a_distanza				0.6
0	72 (95%)	38 (93%)	34 (97%)
1	4 (5.3%)	3 (7.3%)	1 (2.9%)
Unknown	2	2	0
disease_free_survival	32 (20, 52)	41 (18, 66)	26 (20, 46)	0.2
sopravvivenza				0.5
0	32 (41%)	19 (44%)	13 (37%)
1	46 (59%)	24 (56%)	22 (63%)
causa_del_decesso				0.7
0	34 (89%)	21 (91%)	13 (87%)
1	3 (7.9%)	2 (8.7%)	1 (6.7%)
ND	1 (2.6%)	0 (0%)	1 (6.7%)
Unknown	40	20	20
overall_survival	34 (23, 52)	41 (25, 67)	27 (22, 47)	0.10
status	35 (45%)	22 (51%)	13 (37%)	0.2
1 n (%); Median (IQR)
2 Pearson's Chi-squared test; Fisher's exact test; Wilcoxon rank sum test

Tabella con la % di complicanze confrontando chirurgia palliativa con chirurgia radicale con svuotamento cavo ascellare

Characteristic	0, N = 311	1, N = 351	p-value2
complicanze			0.028
0	17 (61%)	29 (85%)
1	11 (39%)	5 (15%)
Unknown	3	1
1 n (%)
2 Pearson's Chi-squared test

Outcome

Per tutta la casistica a disposizione, vengono riportati: - Overall Survival - Controllo locale - Controllo a distanza - Disease Free Survival

## [1] "p=0.9"

Controllo locale

Recidiva a distanza

Disease Free Survival

## [1] "p=0.9"

Cumulative incidence function (CIF) dei decessi dovuti a neoplasia mammaria (progressione) in base all’aver ricevuto chirurgia palliativa (1) o essere stato sottoposto a osservazione (0), tenendo conto della possibilità del decesso per altre cause come evento competitivo all’evento di interesse, che visto l’età molto avanzata è di importanza primaria.

## 46 cases omitted due to missing values

## 3 cases omitted due to missing values

Characteristic	Time 12	Time 24	Time 60	p-value1
pall_vs_watching				0.012
0	13% (4.6%, 25%)	18% (7.8%, 31%)	28% (14%, 44%)
1	2.9% (0.21%, 13%)	2.9% (0.21%, 13%)	2.9% (0.21%, 13%)
1 Gray's Test

Si può inoltre osservare che, analizzando la overall survival facendo un confronto tra la chirurgia palliativa (1) vs la chirurgia radicale (0), non emergono differenze signficative (p= 0.9)

## [1] "p=0.9"

Non emergono differenze neanche per quanto riguarda la Disease Free Survival (p = 0.6)

## [1] "p=0.6"

Allo stesso tempo, si può apprezzare una differenza sia in termini di Overall Survival sia in termini di Disease Free Survival se si confronta la chirurgia palliativa(1) vs la sola osservazione del paziente(0).

Con un modello di regressione logistica univariato, si può apprezzare che la chirurgia palliativa è un importante fattore protettivo per quanto riguarda lo sviluppo di complicanze (p = 0.33)

Characteristic	N	OR1	95% CI1	p-value
pall_vs_asc	62	0.27	0.07, 0.86	0.033
pall_vs_chir	72	0.30	0.09, 0.89	0.039
1 OR = Odds Ratio, CI = Confidence Interval

Modello di Cox univariato per eventuali associazioni tra fattori di rischio presenti nel nostro dataset e la sopravvivenza

Characteristic	N	HR1	95% CI1	p-value
eta_alla_diagnosi	118	1.10	0.97, 1.26	0.13
karnofski_alla_diagnosi	118	0.97	0.96, 0.99	<0.001
ecog_alla_diagnosi	118	1.61	1.25, 2.09	<0.001
charlson_score	118	1.34	1.16, 1.55	<0.001
pregresse_neoplasie	119
0		—	—
1		1.67	0.71, 3.95	0.2
2		0.70	0.28, 1.75	0.4
3		2.44	1.03, 5.81	0.043
mini_mental_state_examination	119	0.91	0.85, 0.97	0.005
geriatric_depression_scale	119	1.03	1.00, 1.07	0.040
peso	119	1.00	0.98, 1.03	0.8
altezza	119	0.98	0.93, 1.03	0.4
bmi	119	1.02	0.95, 1.08	0.6
familiarita	119
0		—	—
1		2.22	0.95, 5.20	0.067
2		0.94	0.42, 2.06	0.9
lato	118
0		—	—
1		0.92	0.56, 1.52	0.8
2		2.75	0.82, 9.25	0.10
palpabilita_mammaria	117
0		—	—
1		1.80	0.25, 13.0	0.6
palpabilita_linfonodale_ascellare	118
0		—	—
1		1.35	0.80, 2.29	0.3
alterazioni_morfologiche_evidenti	118
0		—	—
1		1.23	0.63, 2.39	0.5
2		2.02	0.72, 5.68	0.2
3		2.42	1.11, 5.27	0.026
rmn_mammaria	119
0		—	—
1		0.79	0.25, 2.53	0.7
tc	118
0		—	—
1		1.45	0.87, 2.41	0.2
pet_tc	118
0		—	—
1		3.05	1.20, 7.74	0.019
scintigrafia_ossea	117
0		—	—
1		1.73	0.69, 4.34	0.2
biopsia_linfonodo	118
0		—	—
1		0.81	0.36, 1.78	0.6
meta_diagnosi	119
1		—	—
2		0.84	0.38, 1.86	0.7
n	118
0		—	—
1		1.30	0.78, 2.17	0.3
m	118
0		—	—
1		2.07	0.93, 4.58	0.074
grade	112
1		—	—
2		2.33	0.56, 9.74	0.2
3		3.04	0.72, 12.8	0.13
mib1_43	111	1.01	0.99, 1.03	0.2
er_44	115	0.99	0.99, 1.00	0.13
pr_45	115	1.00	0.99, 1.00	0.5
her2	113
0		—	—
1		1.35	0.76, 2.37	0.3
2		1.27	0.57, 2.83	0.6
3		2.73	0.79, 9.40	0.11
ormonoterapia_neoadiuvante	119
0		—	—
1		1.41	0.87, 2.29	0.2
chirurgia	119
0		—	—
1		0.45	0.28, 0.73	0.001
bls	78
0		—	—
1		0.69	0.29, 1.63	0.4
n_sentinella	78
0		—	—
1		0.42	0.14, 1.24	0.12
2		4.29	1.27, 14.5	0.019
4		0.00	0.00, Inf	>0.9
estemporanea	78
0		—	—
1		0.94	0.32, 2.75	>0.9
linfoadenectomia	78
0		—	—
1		1.23	0.62, 2.45	0.6
chirurgia_ascellare	77
0		—	—
1		0.57	0.30, 1.08	0.084
2		0.57	0.08, 4.37	0.6
chirurgia_palliativa	78
0		—	—
1		1.05	0.52, 2.13	0.9
concordanza	74
0		—	—
1		0.71	0.27, 1.87	0.5
margini	78
0		—	—
1		0.43	0.10, 1.83	0.3
2		1.08	0.32, 3.59	>0.9
multiplo_74	115
0		—	—
1		0.26	0.04, 1.88	0.2
necrosi	78
0		—	—
1		1.52	0.46, 5.06	0.5
invasione_vascolare	78
0		—	—
1		1.02	0.51, 2.02	>0.9
n_sent_tot	78
0		—	—
1		0.53	0.16, 1.78	0.3
2		1.0	0.23, 4.27	>0.9
3		35.4	3.20, 391	0.004
4		0.00	0.00, Inf	>0.9
n_non_sent_pos	77
0		—	—
1		0.35	0.05, 2.64	0.3
12		2.84	0.37, 21.5	0.3
2		1.06	0.25, 4.52	>0.9
3		3.55	0.47, 27.1	0.2
4		1.04	0.24, 4.48	>0.9
6		2.18	0.51, 9.34	0.3
7		0.00	0.00, Inf	>0.9
complicanze	76
0		—	—
1		1.54	0.71, 3.36	0.3
radioterapia_adiuvante	118	0.87	0.21, 3.57	0.8
presenza_di_recidiva	119	1.96	1.06, 3.61	0.031
rec_locale	112
0		—	—
1		2.50	1.11, 5.64	0.027
recidiva_a_distanza	112
0		—	—
1		1.67	0.78, 3.57	0.2
disease_free_survival	119	0.87	0.85, 0.90	<0.001
sopravvivenza	119
0		—	—
1		1.53	0.92, 2.54	0.10
pall_vs_chir	78	1.05	0.52, 2.13	0.9
pall_vs_asc	66	0.95	0.45, 2.02	0.9
pall_vs_watching	76	0.48	0.25, 0.91	0.026
tipo_intervento	119
0		—	—
1		0.47	0.24, 0.89	0.021
2		0.44	0.25, 0.76	0.003
luminal	115	1.32	0.91, 1.91	0.14
stadio_cat	119
advanced		—	—
early stage		0.44	0.20, 0.95	0.038
locally advanced		0.47	0.21, 1.07	0.072
t_new	114
T1		—	—
T2		1.53	0.83, 2.79	0.2
T3		1.79	0.64, 5.02	0.3
dimensioni_esami_strum	114	1.01	1.00, 1.03	0.076
stadio_new	114
IA		—	—
IB		0.77	0.17, 3.45	0.7
IIA		1.25	0.63, 2.50	0.5
IIB		1.70	0.78, 3.68	0.2
IIIA		1.38	0.31, 6.23	0.7
IV		2.67	1.04, 6.84	0.041
stadio_cat_new	114
advanced		—	—
early stage		0.42	0.19, 0.96	0.039
locally advanced		0.62	0.25, 1.52	0.3
1 HR = Hazard Ratio, CI = Confidence Interval

Modello di Cox multivariato, tenendo come predittori solamente le variabili che all’univariata hanno un p statisticamente signficativo (p<=0.05).

Si può notare che anche attraverso modello di Cox multivariato sottoporre il paziente a chirurgia palliativa piuttosto che all’osservazione migliora la prognosi, anche nel momento in cui si aggiusta per il geriatric assessment.

Characteristic	HR1	95% CI1	p-value
eta_alla_diagnosi	0.96	0.79, 1.17	0.7
pregresse_neoplasie
0	—	—
1	2.12	0.68, 6.60	0.2
2	0.37	0.08, 1.62	0.2
3	2.97	0.94, 9.38	0.063
ormonoterapia_neoadiuvante
0	—	—
1	0.43	0.15, 1.25	0.12
alterazioni_morfologiche_evidenti
0	—	—
1	0.87	0.36, 2.09	0.8
2	1.15	0.27, 4.84	0.8
3	1.25	0.45, 3.49	0.7
familiarita
0	—	—
1	2.33	0.62, 8.84	0.2
2	0.91	0.34, 2.48	0.9
geriatric_depression_scale	0.96	0.89, 1.03	0.2
her2
0	—	—
1	1.21	0.60, 2.46	0.6
2	1.13	0.39, 3.32	0.8
3	2.82	0.59, 13.6	0.2
mini_mental_state_examination	0.97	0.86, 1.10	0.6
stadio_cat_new
advanced	—	—
early stage	0.45	0.16, 1.32	0.15
locally advanced	0.84	0.28, 2.51	0.8
charlson_score	1.48	1.17, 1.87	0.001
ecog_alla_diagnosi	0.73	0.25, 2.10	0.6
karnofski_alla_diagnosi	0.96	0.90, 1.02	0.2
tipo_intervento
0	—	—
1	0.20	0.05, 0.82	0.026
2	0.19	0.05, 0.70	0.012
luminal	1.57	0.97, 2.56	0.068
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	HR1	95% CI1	p-value
eta_alla_diagnosi	0.86	0.60, 1.24	0.4
pregresse_neoplasie
0	—	—
1	10.3	1.40, 75.7	0.022
2	0.80	0.12, 5.43	0.8
3	5.53	1.02, 30.0	0.047
ormonoterapia_neoadiuvante
0	—	—
1	0.88	0.08, 10.2	>0.9
alterazioni_morfologiche_evidenti
0	—	—
1	0.90	0.13, 6.07	>0.9
2	5.17	0.58, 46.2	0.14
3	0.51	0.06, 4.44	0.5
familiarita
0	—	—
1	1.77	0.31, 10.2	0.5
2	2.50	0.31, 20.1	0.4
stadio_cat_new
early stage	—	—
locally advanced	3.19	0.09, 108	0.5
geriatric_depression_scale	0.94	0.83, 1.07	0.3
mini_mental_state_examination	1.00	0.79, 1.26	>0.9
charlson_score	1.37	0.87, 2.15	0.2
ecog_alla_diagnosi	0.73	0.11, 5.02	0.8
karnofski_alla_diagnosi	0.97	0.86, 1.10	0.7
pall_vs_watching	0.24	0.02, 2.48	0.2
luminal	1.29	0.48, 3.41	0.6
1 HR = Hazard Ratio, CI = Confidence Interval