main code
RSD.sim <- function(target, p.true, ncohort, cohortsize, maxt=1, prior.p=NA, accrual=3, maxpen=0.5,
dist1=1, dist2=1,alpha=0.5,n.earlystop = 100, startdose = 1,
p.saf = target-0.05, p.tox = target+0.05, cutoff.eli = 0.95,
extrasafe = FALSE, offset = 0.05, ntrial = 1000, seed=123, design=1){
gen.tite<-function(dist=1, n, pi, alpha=0.5, Tobs=1)
{
############ subroutines ############
weib<-function(n, pi, pihalft)
{
## solve parameters for Weibull given pi=1-S(T) and phalft=1-S(T/2)
alpha = log(log(1-pi)/log(1-pihalft))/log(2);
lambda = -log(1-pi)/(Tobs^alpha);
t = (-log(runif(n))/lambda)^(1/alpha);
return(t);
}
llogit<-function(n, pi, pihalft)
{
## solve parameters for log-logistic given pi=1-S(T) and phalft=1-S(T/2)
alpha = log((1/(1-pi)-1)/(1/(1-pihalft)-1))/log(2);
lambda = (1/(1-pi)-1)/(Tobs^alpha);
t = ((1/runif(n)-1)/lambda)^(1/alpha);
return(t);
}
############ end of subroutines ############
tox = rep(0, n); #DLT 여부
t.tox = rep(0, n); #TTT생존시간
#### uniform
if(dist==1) { #50% event in (0, 1/2T)
tox = rbinom(n, 1, pi); #표본크기,시행횟수,발생확률
ntox.st = sum(tox); #총 DLT 발생수
t.tox[tox==0]=Tobs; #DLT가 발생하지 않은 경우, TTT=Tobs관찰시간
t.tox[tox==1]=runif(ntox.st, 0, Tobs); #DLT 발생한 경우, TTT~Unif(0,관찰시간)
}
#### Weibull
if(dist==2)
{
pihalft = alpha*pi; # alpha*100% event in (0, 1/2T)
t.tox = weib(n, pi, pihalft); #solve parameters for Weibull
tox[t.tox<=Tobs]=1; #TTT가 1보다 작거나 같은 경우, DLT=1
ntox.st = sum(tox); #총 DLT 발생수
t.tox[tox==0]=Tobs; #DLT가 발생하지 않은 경우, TTT=관찰시간
}
#### log-logistic
if(dist==3)
{
pihalft = alpha*pi; # alpha*100% event in (0, 1/2T)
t.tox = llogit(n, pi, pihalft); #solve parameters for log-logistic
tox[t.tox<=Tobs]=1; #TTT가 1보다 작거나 같은 경우, DLT=1
ntox.st = sum(tox); #총 DLT 발생수
t.tox[tox==0]=Tobs; #DLT가 발생하지 않은 경우, TTT=관찰시간
}
return(list(tox=tox, t.tox=t.tox, ntox.st=ntox.st)); #DLT발생여부,TTT,총DLT발생수
}
R6=function(enroll, dlt, pend, d){ # 벡터(enroll,dlt), 상수(pend,d)
mtd=0;
earlystop=0;
pending=0;
en=enroll[d]; #용량 d를 할당받은 인원 수
dl=dlt[d]; #용량 d에서 나타난 dlt 수
pe=pend[d];
if(en==1){d=d
} else if(en==2){
if(dl==2){if(d==1){earlystop=1;} else {if(enroll[d-1]==6){mtd=d-1;earlystop=1;} else {d=d-1;}}
}else{d=d;}
} else if(en==3){
if(dl>=2){if(d==1){earlystop=1;} else {if(enroll[d-1]==6){mtd=d-1;earlystop=1;} else {d=d-1;}}
}else if(dl==0 && pe==0){if(d==ndose){mtd=d;earlystop=1;}else{d=d+1;}
}else{d=d;}
} else if(en==4){
if(dl>=2){if(d==1){earlystop=1;} else {if(enroll[d-1]==6){mtd=d-1;earlystop=1;} else {d=d-1;}}
}else if(dl==0 && pe==0){if(d==ndose){mtd=d;earlystop=1;}else{d=d+1;}
}else{d=d;}
} else if(en==5){
if(dl>=2){if(d==1){earlystop=1;} else {if(enroll[d-1]==6){mtd=d-1;earlystop=1;} else {d=d-1;}}
}else if(dl==0 && pe==0){if(d==ndose){mtd=d;earlystop=1;}else{d=d+1;}
}else{d=d;}
} else{
if(dl>=2){if(d==1){earlystop=1;} else {if(enroll[d-1]==6){mtd=d-1;earlystop=1;} else {d=d-1;}}
}else if(dl<=1 && pe==0){if(d==ndose){mtd=d;earlystop=1;}else{d=d+1;}
}else if(dl==0 && pe==1){if(d==ndose){mtd=d;earlystop=1;}else{d=d+1;}
}else{pending=1;}
}
out=list(d=d,mtd=mtd,earlystop=earlystop,pending=pending)
return(out)
}
### simple error checking
if(target<0.05) {cat("Error: the target is too low! \n"); return();}
if(target>0.6) {cat("Error: the target is too high! \n"); return();}
if((target-p.saf)<(0.1*target)) {cat("Error: the probability deemed safe cannot be higher than or too close to the target! \n"); return();}
if((p.tox-target)<(0.1*target)) {cat("Error: the probability deemed toxic cannot be lower than or too close to the target! \n"); return();}
if(p.saf<0.05) {cat("Error: the lower interval boundary cannot be too close to 0! \n"); return();}
if(p.tox>0.95) {cat("Error: the upper interval boundary cannot be too close to 1! \n"); return();}
if(offset>=0.5) {cat("Error: the offset is too large! \n"); return();}
if(!is.na(prior.p[1])){if(length(prior.p)!=3){cat("Error: The length of the prior probabilities should be 3! \n"); return();}}
if(n.earlystop<=6) {cat("Warning: the value of n.earlystop is too low to ensure good operating characteristics. Recommend n.earlystop = 9 to 18 \n"); return();}
if(is.na(maxpen)){maxpen=0.5;}
if(maxpen<0 || maxpen>0.65) {cat("Error: the value of maxpen should lie within (0,0.65]! \n"); return();}
epi1<-target-p.saf;
epi2<-p.tox-target;
#set.seed(seed);
if(is.na(prior.p[1])){prior.p = rep(1/3,3)} #useless?
prior.p = prior.p/sum(prior.p) #useless?
durationV = rep(0, ntrial); #useless?
npendV = rep(0, ntrial); #useless?
a<-b<-1 #useless?
set.seed(6);
ndose=length(p.true);
npts = ncohort*cohortsize;
Y=matrix(rep(0, ndose*ntrial), ncol=ndose); # store toxicity outcome
N=matrix(rep(0, ndose*ntrial), ncol=ndose); # store the number of patients
dselect = rep(0, ntrial); # store the selected dose level
ea = rep(0, ntrial);
for(trial in 1:ntrial) #시험횟수만큼 진행
{
y=NULL; #DLT여부 toxicity indicator for each subject
dv=NULL; #각 환자에게 할당된 용량 dose for each subject
n.d = rep(0, ndose); #각 용량에 배정된 환자 수 number of patient at each dose
y.d = rep(0, ndose); #각 용량에서 나타나는 DLT수 number of toxicity at each dose
t.enter=NULL; #시험 참가 시간 time enter the study
t.event=NULL; #생존시간 time to event
t.decision = 0; #결정시간 decision making time
d = startdose; #현재의 용량 current dose level
earlystop = 0; #조기종료 여부 indicate if trial stops early
elimi = rep(0, ndose)
npend = 0;
for(i in 1:ncohort) #여러 개의 코호트
{
# generate data for the new patient
for(j in 1:cohortsize) #한 코호트 안에서
{
if(j==1) { t.enter = c(t.enter, t.decision); } #첫 환자의 경우 시험참가시간=(결정시간=0)
else { #다음 환자의 경우
if(dist2==1){ t.enter = c(t.enter, t.enter[length(t.enter)] + runif(1, 0, 2/accrual))} #도착간격시간이 unif(평균=도착간격시간)을 따르는 경우 , 시험참가시간=(0, 0+runif, 0+runif+runif...)
if(dist2==2){ t.enter = c(t.enter, t.enter[length(t.enter)] + rexp(1, rate=accrual))} #도착간격시간이 지수분포(평균=도착간격시간)를 따르는 경우, 시험참가시간=(0, 0+rexp, 0+rexp+rexp...)
if(dist2==3){ t.enter = c(t.enter, t.enter[length(t.enter)] + rpois(1, lambda=1/accrual))}
}
}
obscohort = gen.tite(dist1, cohortsize, p.true[d], alpha=alpha,T=maxt); #현재 용량에서 생존시간이 dist1을 따르고 코호트가 cohortsize명일 때, DLT 발생시점(발생하지 않은 경우 (t.tox)생존시간=관찰시간)
t.event = c(t.event, obscohort$t.tox); #생존시간
y = c(y, obscohort$tox); #DLT여부
dv = c(dv, rep(d, cohortsize)); #각 환자에게 배정된 용량=현재 용량을 cohortsize명에게 할당
t.decision = t.enter[length(t.enter)]; #결정시간=코호트 내 마지막 환자의 참가시점
nobs=-1; pending=1;
d.curr=d; #현재용량
npend = npend-1; #npend=0-1
while(pending==1)
{
npend = npend+1; #npend=0
pending = 0;
if(i==ncohort) { t.decision = t.decision + maxt; } #마지막 코호트의 경우, 결정시간=마지막 환자의 참가시점+최대관찰시간
else { #마지막 코호트가 아닌 경우, t.decision을 업데이트
if(dist2==1){t.decision = t.decision + runif(1, 0, 2/accrual)} #n+1 코호트의 경우, n코호트의 마지막 환자 참가시점+도착간격시간(unif)=코호트 내 첫 환자의 참가시점
if(dist2==2){t.decision = t.decision + rexp(1, rate=accrual)} #n+1 코호트의 경우, n코호트의 마지막 환자 참가시점+도착간격시간(exp)=코호트 내 첫 환자의 참가시점
if(dist2==3){t.decision = t.decision + rpois(1, lambda=1/accrual)}
}
# determine which observation are observed
delta = ((t.enter+t.event)<=t.decision); #시험참가시간+생존시간이 결정시간 이하인 경우(즉, 다음 환자가 들어오기 전 관찰이 끝난 경우), "TRUE"
t = pmin(t.event, t.decision-t.enter, maxt); ##생존시간, 결정시간-참가시간(새 환자가 들어오기까지의 관찰시간), 최대관찰시간 중 가장 작은 것 used for recording potential censoring time
cset = (dv==d); #각 환자에게 할당된 용량이 현재의 용량과 같은 경우, "TRUE"
delta.curr = delta[cset]; #현재 용량을 할당받은 사람 중 관찰완료는 "TRUE"
t.curr = t[cset]; #현재 용량을 할당받은 사람들의 생존시간|중간관찰시간|최대관찰시간
ntox.curr = sum((y[cset])[delta.curr==1]); #현재 용량을 할당받은 사람 중 관찰이 완료된 총 DLT 발생수
#totalt = sum(t.curr[delta.curr==0])/maxt;
totalt = t.curr[delta.curr==0] #관찰이 완료된 사람의 생존시간|중간관찰시간|최대관찰시간
##piecewise uniform weight(p.20)
totalt = 3*prior.p[1]*totalt*(totalt<=maxt/3)+ #관찰시간이 최대관찰시간의 1/3 이하인 경우
((prior.p[1]-prior.p[2])*maxt+3*prior.p[2]*totalt)*(maxt/3<totalt & totalt<=2*maxt/3)+ #관찰시간이 최대관찰시간의 1/3이상, 2/3 이하인 경우
((prior.p[1]+prior.p[2]-2*prior.p[3])*maxt+3*prior.p[3]*totalt)*(2*maxt/3<totalt & totalt<=maxt) #관찰시간이 최대관찰시간의 2/3이상, 최대관찰시간 이하일 경우
totalt = sum(totalt)/maxt #현재까지 관찰한 시간이 최대관찰시간의 몇 %만큼인지
n.curr = sum(cset); #현재 용량을 할당받은 사람의 수
n.pend = sum(delta[cset]==0); #현재 용량을 할당받은 사람 중 관찰이 완료되지 않은 사람 수
nobs = sum(delta[cset]); #현재 용량을 할당받은 사람 중 관찰이 완료된 사람 수
#Enroll, DLT, Pend
Enroll=rep(0,ndose);
DLT=rep(0,ndose);
Pend=rep(0,ndose);
for(k in 1:ndose){ #n개 dose에 대해
DLT[k] = sum(y[dv==k]);
Enroll[k] = sum(dv==k);
Pend[k] = sum(delta[dv==k]==0);
}
#check whether the trial should be early terminated
if(n.curr>=n.earlystop){break;} #현재 용량을 할당받은 사람의 수가 n.earlystop보다 많으면 조기종료
#check whether the trial should be suspended
if(n.pend<0) {pending=1;}
else
{
y0<-ntox.curr #현재 용량을 할당받은 사람 중 관찰이 완료된 총 DLT 발생수
n0<-n.curr-n.pend+totalt #유효인원수ESS
#r6
r6=R6(Enroll,DLT,Pend,d)
earlystop=r6$earlystop;
mtd=r6$mtd;
pending=r6$pending;
d=r6$d
if(mtd>0){break;}
}
}
if(earlystop==1){break;} #조기종료=1이면 조기종료
}
for(k in 1:ndose){ #n개 dose에 대해
y.d[k] = sum(y[dv==k]);
n.d[k] = sum(dv==k);
}
npendV[trial]= npend; #각 trial에서 나타난 지연 수
Y[trial, ] = y.d #각 trial에서 나타난 용량 별 DLT 수
N[trial, ] = n.d #각 trial에서 나타난 용량 별 할당환자 수
durationV[trial] = t.decision #각 trial의 duration
if (mtd==0 & earlystop == 1) {ea[trial] = 1}
if (mtd>0) {dselect[trial]=mtd} #선택된 용량
}
selpercent = rep(0, ndose) #각 용량이 선택된 확률
selpercent=rep(0, ndose);
nptsdose = apply(N,2,mean); #각 용량을 할당받은 평균 환자 수
ntoxdose = apply(Y,2,mean); #각 용량을 할당받고 DLT가 나타난 평균
for(i in 1:ndose) {selpercent[i]=sum(dselect==i)/ntrial*100; }
dist=abs(p.true-target);
realmtd=p.true[which(min(dist)==dist)];
if(length(which(p.true==realmtd))>0) # if MTD exists, calculate risk of overdosing
{
if (which(p.true==realmtd) == ndose-1) {
overdosing50=mean(N[,p.true>realmtd]>0.5*npts)*100;
overdosing60=mean(N[,p.true>realmtd]>0.6*npts)*100;
overdosing80=mean(N[,p.true>realmtd]>0.8*npts)*100;
} else {
overdosing50=mean(rowSums(N[,p.true>realmtd])>0.5*npts)*100;
overdosing60=mean(rowSums(N[,p.true>realmtd])>0.6*npts)*100;
overdosing80=mean(rowSums(N[,p.true>realmtd])>0.8*npts)*100;
}
out=list(selpercent=selpercent, npatients=nptsdose, ntox=ntoxdose, totaltox=sum(Y)/ntrial, totaln=sum(N)/ntrial,
percentstop=sum(ea)/ntrial*100, poorallocation=mean(N[, p.true==realmtd]<npts/ndose)*100,
overdose50=overdosing50, overdose60=overdosing60, overdose80=overdosing80, duration=mean(durationV),sdduration=sqrt(var(durationV)),simu.setup=data.frame(target=target, p.true=p.true, ncohort=ncohort, cohortsize = cohortsize,
startdose = startdose,p.saf = p.saf, p.tox = p.tox, cutoff.eli = cutoff.eli, extrasafe = extrasafe, offset = offset,
ntrial = ntrial, dose=1:ndose),flowchart=TRUE);
}
else {
out=list(selpercent=selpercent, npatients=nptsdose, ntox=ntoxdose, totaltox=sum(Y)/ntrial, totaln=sum(N)/ntrial,
percentstop=sum(ea)/ntrial*100, duration=mean(durationV),sdduration=sqrt(var(durationV)),simu.setup=data.frame(target=target, p.true=p.true, ncohort=ncohort, cohortsize = cohortsize,
startdose = startdose,p.saf = p.saf, p.tox = p.tox, cutoff.eli = cutoff.eli, extrasafe = extrasafe, offset = offset, ntrial = ntrial,
dose=1:ndose),flowchart=TRUE);
}
return(out);
}
simulation
setup
target<-0.2
P<-matrix(0,5,6)
## Six fixed scenarios in the paper
P[1,]<-c(0.05,0.10,0.20,0.30,0.50,0.70)
P[2,]<-c(0.30,0.40,0.52,0.61,0.76,0.87)
P[3,]<-c(0.05,0.06,0.08,0.11,0.19,0.34)
P[4,]<-c(0.06,0.08,0.12,0.18,0.40,0.71)
P[5,]<-c(0.00,0.00,0.03,0.05,0.11,0.22)
start
c.uni.21.c1=list(NULL,NULL,NULL,NULL,NULL)
c.uni.14.c1=list(NULL,NULL,NULL,NULL,NULL)
c.uni.7.c1=list(NULL,NULL,NULL,NULL,NULL)
c.wei.21.c1=list(NULL,NULL,NULL,NULL,NULL)
c.wei.14.c1=list(NULL,NULL,NULL,NULL,NULL)
c.wei.7.c1=list(NULL,NULL,NULL,NULL,NULL)
c.uni.21.c3=list(NULL,NULL,NULL,NULL,NULL)
c.uni.14.c3=list(NULL,NULL,NULL,NULL,NULL)
c.uni.7.c3=list(NULL,NULL,NULL,NULL,NULL)
c.wei.21.c3=list(NULL,NULL,NULL,NULL,NULL)
c.wei.14.c3=list(NULL,NULL,NULL,NULL,NULL)
c.wei.7.c3=list(NULL,NULL,NULL,NULL,NULL)
for (i in 1:5){
c.uni.21.c1[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=1,ncohort=36,
P[i,],dist1=1,accrual=1);
c.uni.14.c1[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=1,ncohort=36,
P[i,],dist1=1,accrual=2);
c.uni.7.c1[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=1,ncohort=36,
P[i,],dist1=1,accrual=3);
c.wei.21.c1[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=1,ncohort=36,
P[i,],dist1=2,accrual=1);
c.wei.14.c1[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=1,ncohort=36,
P[i,],dist1=2,accrual=2);
c.wei.7.c1[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=1,ncohort=36,
P[i,],dist1=2,accrual=3);
c.uni.21.c3[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=3,ncohort=12,
P[i,],dist1=1,accrual=1);
c.uni.14.c3[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=3,ncohort=12,
P[i,],dist1=1,accrual=2);
c.uni.7.c3[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=3,ncohort=12,
P[i,],dist1=1,accrual=3);
c.wei.21.c3[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=3,ncohort=12,
P[i,],dist1=2,accrual=1);
c.wei.14.c3[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=3,ncohort=12,
P[i,],dist1=2,accrual=2);
c.wei.7.c3[[i]]=RSD.sim(target,ntrial=1000,dist2=2,
cohortsize=3,ncohort=12,
P[i,],dist1=2,accrual=3);
}
c.uni.21.c1
## [[1]]
## [[1]]$selpercent
## [1] 11.1 28.9 31.2 21.6 3.4 0.0
##
## [[1]]$npatients
## [1] 4.687 4.949 4.577 2.975 1.045 0.125
##
## [[1]]$ntox
## [1] 0.259 0.496 0.899 0.875 0.544 0.091
##
## [[1]]$totaltox
## [1] 3.164
##
## [[1]]$totaln
## [1] 18.358
##
## [[1]]$percentstop
## [1] 3.8
##
## [[1]]$poorallocation
## [1] 42.9
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 19.41528
##
## [[1]]$sdduration
## [1] 7.186943
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 31.2 10.0 1.1 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 4.725 2.100 0.516 0.051 0.003 0.000
##
## [[2]]$ntox
## [1] 1.437 0.824 0.272 0.030 0.002 0.000
##
## [[2]]$totaltox
## [1] 2.565
##
## [[2]]$totaln
## [1] 7.395
##
## [[2]]$percentstop
## [1] 57.7
##
## [[2]]$poorallocation
## [1] 51.5
##
## [[2]]$overdose50
## [1] 0.1
##
## [[2]]$overdose60
## [1] 0.1
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 7.726212
##
## [[2]]$sdduration
## [1] 5.622241
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 5.2 6.3 10.7 23.5 33.4 17.5
##
## [[3]]$npatients
## [1] 4.635 4.552 4.418 4.367 4.037 2.366
##
## [[3]]$ntox
## [1] 0.249 0.292 0.366 0.487 0.776 0.828
##
## [[3]]$totaltox
## [1] 2.998
##
## [[3]]$totaln
## [1] 24.375
##
## [[3]]$percentstop
## [1] 3.4
##
## [[3]]$poorallocation
## [1] 48.2
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 25.8831
##
## [[3]]$sdduration
## [1] 8.559914
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 7.5 12.4 21.3 42.9 11.2 0.1
##
## [[4]]$npatients
## [1] 4.617 4.603 4.537 4.168 2.614 0.428
##
## [[4]]$ntox
## [1] 0.272 0.384 0.546 0.745 1.074 0.307
##
## [[4]]$totaltox
## [1] 3.328
##
## [[4]]$totaln
## [1] 20.967
##
## [[4]]$percentstop
## [1] 4.5
##
## [[4]]$poorallocation
## [1] 43.8
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 22.29232
##
## [[4]]$sdduration
## [1] 8.037633
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 0.9 2.9 11.8 32.8 51.5
##
## [[5]]$npatients
## [1] 4.278 4.297 4.451 4.708 5.026 4.131
##
## [[5]]$ntox
## [1] 0.000 0.000 0.101 0.246 0.553 0.933
##
## [[5]]$totaltox
## [1] 1.833
##
## [[5]]$totaln
## [1] 26.891
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 61.2
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 27.99627
##
## [[5]]$sdduration
## [1] 5.634655
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.uni.14.c1
## [[1]]
## [[1]]$selpercent
## [1] 11.4 28.2 31.6 23.2 1.7 0.0
##
## [[1]]$npatients
## [1] 5.398 5.282 4.554 2.860 1.001 0.060
##
## [[1]]$ntox
## [1] 0.295 0.569 0.894 0.846 0.525 0.041
##
## [[1]]$totaltox
## [1] 3.17
##
## [[1]]$totaln
## [1] 19.155
##
## [[1]]$percentstop
## [1] 3.9
##
## [[1]]$poorallocation
## [1] 40.5
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 11.25122
##
## [[1]]$sdduration
## [1] 4.344853
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.4 7.9 0.8 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 4.831 1.881 0.334 0.029 0.000 0.000
##
## [[2]]$ntox
## [1] 1.465 0.758 0.174 0.016 0.000 0.000
##
## [[2]]$totaltox
## [1] 2.413
##
## [[2]]$totaln
## [1] 7.075
##
## [[2]]$percentstop
## [1] 58.9
##
## [[2]]$poorallocation
## [1] 48.4
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 3.940213
##
## [[2]]$sdduration
## [1] 2.932789
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 4.2 7.3 9.7 23.1 33.6 17.9
##
## [[3]]$npatients
## [1] 5.426 5.220 4.956 4.613 4.050 2.447
##
## [[3]]$ntox
## [1] 0.298 0.322 0.409 0.485 0.770 0.830
##
## [[3]]$totaltox
## [1] 3.114
##
## [[3]]$totaln
## [1] 26.712
##
## [[3]]$percentstop
## [1] 3.8
##
## [[3]]$poorallocation
## [1] 46.9
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 15.87804
##
## [[3]]$sdduration
## [1] 5.325819
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 6.3 15.6 19.5 41.7 12.6 0.1
##
## [[4]]$npatients
## [1] 5.391 5.280 4.845 4.083 2.489 0.408
##
## [[4]]$ntox
## [1] 0.317 0.404 0.640 0.706 0.974 0.295
##
## [[4]]$totaltox
## [1] 3.336
##
## [[4]]$totaln
## [1] 22.496
##
## [[4]]$percentstop
## [1] 4.2
##
## [[4]]$poorallocation
## [1] 43.6
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 13.1999
##
## [[4]]$sdduration
## [1] 4.765894
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.1 3.4 13.1 33.9 48.3
##
## [[5]]$npatients
## [1] 5.312 5.277 5.348 5.378 5.286 4.165
##
## [[5]]$ntox
## [1] 0.000 0.000 0.152 0.297 0.602 0.973
##
## [[5]]$totaltox
## [1] 2.024
##
## [[5]]$totaln
## [1] 30.766
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 53.3
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 17.98716
##
## [[5]]$sdduration
## [1] 3.271674
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.uni.7.c1
## [[1]]
## [[1]]$selpercent
## [1] 11.0 28.8 32.7 20.9 4.0 0.1
##
## [[1]]$npatients
## [1] 5.758 5.612 4.642 2.821 0.978 0.114
##
## [[1]]$ntox
## [1] 0.296 0.581 0.935 0.850 0.460 0.081
##
## [[1]]$totaltox
## [1] 3.203
##
## [[1]]$totaln
## [1] 19.925
##
## [[1]]$percentstop
## [1] 2.5
##
## [[1]]$poorallocation
## [1] 38.5
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 8.625446
##
## [[1]]$sdduration
## [1] 3.228311
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.8 9.0 1.1 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 4.866 1.881 0.385 0.039 0.000 0.000
##
## [[2]]$ntox
## [1] 1.447 0.754 0.194 0.022 0.000 0.000
##
## [[2]]$totaltox
## [1] 2.417
##
## [[2]]$totaln
## [1] 7.171
##
## [[2]]$percentstop
## [1] 57.1
##
## [[2]]$poorallocation
## [1] 47.1
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 2.858401
##
## [[2]]$sdduration
## [1] 2.174426
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 5.1 7.4 12.1 23.0 31.4 17.6
##
## [[3]]$npatients
## [1] 5.762 5.543 5.265 4.763 3.919 2.325
##
## [[3]]$ntox
## [1] 0.298 0.342 0.428 0.533 0.741 0.771
##
## [[3]]$totaltox
## [1] 3.113
##
## [[3]]$totaln
## [1] 27.577
##
## [[3]]$percentstop
## [1] 2.9
##
## [[3]]$poorallocation
## [1] 46.9
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 12.14465
##
## [[3]]$sdduration
## [1] 4.136518
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 7.4 13.4 21.9 41.1 11.7 0.2
##
## [[4]]$npatients
## [1] 5.705 5.466 4.958 4.118 2.308 0.333
##
## [[4]]$ntox
## [1] 0.348 0.454 0.601 0.726 0.926 0.245
##
## [[4]]$totaltox
## [1] 3.3
##
## [[4]]$totaln
## [1] 22.888
##
## [[4]]$percentstop
## [1] 4.3
##
## [[4]]$poorallocation
## [1] 42.9
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 9.964285
##
## [[4]]$sdduration
## [1] 3.671217
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.4 4.5 12.0 30.4 51.2
##
## [[5]]$npatients
## [1] 5.776 5.717 5.734 5.632 5.358 4.331
##
## [[5]]$ntox
## [1] 0.000 0.000 0.210 0.329 0.585 0.912
##
## [[5]]$totaltox
## [1] 2.036
##
## [[5]]$totaln
## [1] 32.548
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 46.3
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 14.37937
##
## [[5]]$sdduration
## [1] 2.671015
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.wei.21.c1
## [[1]]
## [[1]]$selpercent
## [1] 10.7 29.7 30.9 22.9 2.7 0.1
##
## [[1]]$npatients
## [1] 4.664 4.944 4.647 3.002 1.133 0.098
##
## [[1]]$ntox
## [1] 0.229 0.520 0.957 0.876 0.565 0.066
##
## [[1]]$totaltox
## [1] 3.213
##
## [[1]]$totaln
## [1] 18.488
##
## [[1]]$percentstop
## [1] 3
##
## [[1]]$poorallocation
## [1] 43.2
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 19.55359
##
## [[1]]$sdduration
## [1] 7.181207
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 31.3 10.3 1.0 0.1 0.0 0.0
##
## [[2]]$npatients
## [1] 4.754 2.093 0.536 0.042 0.003 0.000
##
## [[2]]$ntox
## [1] 1.409 0.838 0.273 0.027 0.002 0.000
##
## [[2]]$totaltox
## [1] 2.549
##
## [[2]]$totaln
## [1] 7.428
##
## [[2]]$percentstop
## [1] 57.3
##
## [[2]]$poorallocation
## [1] 52.5
##
## [[2]]$overdose50
## [1] 0.1
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 7.710004
##
## [[2]]$sdduration
## [1] 5.526757
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 3.7 6.4 12.1 22.4 32.1 19.8
##
## [[3]]$npatients
## [1] 4.582 4.528 4.582 4.462 4.057 2.417
##
## [[3]]$ntox
## [1] 0.253 0.278 0.394 0.520 0.768 0.811
##
## [[3]]$totaltox
## [1] 3.024
##
## [[3]]$totaln
## [1] 24.628
##
## [[3]]$percentstop
## [1] 3.5
##
## [[3]]$poorallocation
## [1] 47.7
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 26.21784
##
## [[3]]$sdduration
## [1] 8.539064
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 7.3 15.1 20.3 38.6 14.4 0.2
##
## [[4]]$npatients
## [1] 4.658 4.705 4.588 4.113 2.631 0.519
##
## [[4]]$ntox
## [1] 0.276 0.406 0.588 0.710 1.019 0.374
##
## [[4]]$totaltox
## [1] 3.373
##
## [[4]]$totaln
## [1] 21.214
##
## [[4]]$percentstop
## [1] 4.1
##
## [[4]]$poorallocation
## [1] 43.2
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 22.55496
##
## [[4]]$sdduration
## [1] 8.242518
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.6 4.0 13.2 30.2 51.0
##
## [[5]]$npatients
## [1] 4.261 4.226 4.533 4.769 4.934 3.995
##
## [[5]]$ntox
## [1] 0.000 0.000 0.163 0.272 0.581 0.879
##
## [[5]]$totaltox
## [1] 1.895
##
## [[5]]$totaln
## [1] 26.718
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 60.6
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 28.00919
##
## [[5]]$sdduration
## [1] 5.808378
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.wei.14.c1
## [[1]]
## [[1]]$selpercent
## [1] 12.4 26.9 31.0 23.1 2.3 0.0
##
## [[1]]$npatients
## [1] 5.392 5.282 4.458 2.817 1.017 0.071
##
## [[1]]$ntox
## [1] 0.287 0.545 0.858 0.803 0.522 0.053
##
## [[1]]$totaltox
## [1] 3.068
##
## [[1]]$totaln
## [1] 19.037
##
## [[1]]$percentstop
## [1] 4.3
##
## [[1]]$poorallocation
## [1] 41.9
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 11.1041
##
## [[1]]$sdduration
## [1] 4.50046
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.8 8.5 0.9 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 4.839 1.888 0.396 0.032 0.000 0.000
##
## [[2]]$ntox
## [1] 1.436 0.772 0.201 0.022 0.000 0.000
##
## [[2]]$totaltox
## [1] 2.431
##
## [[2]]$totaln
## [1] 7.155
##
## [[2]]$percentstop
## [1] 57.8
##
## [[2]]$poorallocation
## [1] 47.4
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 3.949356
##
## [[2]]$sdduration
## [1] 2.933363
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 3.9 6.8 12.2 24.5 32.9 16.3
##
## [[3]]$npatients
## [1] 5.379 5.211 5.040 4.723 3.993 2.295
##
## [[3]]$ntox
## [1] 0.278 0.327 0.399 0.541 0.791 0.815
##
## [[3]]$totaltox
## [1] 3.151
##
## [[3]]$totaln
## [1] 26.641
##
## [[3]]$percentstop
## [1] 3.3
##
## [[3]]$poorallocation
## [1] 47
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 15.70676
##
## [[3]]$sdduration
## [1] 5.205026
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 8.1 14.0 20.5 39.1 13.6 0.0
##
## [[4]]$npatients
## [1] 5.378 5.137 4.761 4.055 2.439 0.389
##
## [[4]]$ntox
## [1] 0.333 0.445 0.604 0.700 0.942 0.295
##
## [[4]]$totaltox
## [1] 3.319
##
## [[4]]$totaln
## [1] 22.159
##
## [[4]]$percentstop
## [1] 4.7
##
## [[4]]$poorallocation
## [1] 44.4
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 12.99841
##
## [[4]]$sdduration
## [1] 4.933337
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.7 2.0 14.0 30.3 51.6
##
## [[5]]$npatients
## [1] 5.273 5.242 5.351 5.346 5.301 4.199
##
## [[5]]$ntox
## [1] 0.000 0.000 0.167 0.277 0.604 0.906
##
## [[5]]$totaltox
## [1] 1.954
##
## [[5]]$totaln
## [1] 30.712
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 53.1
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 18.10374
##
## [[5]]$sdduration
## [1] 3.322756
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.wei.7.c1
## [[1]]
## [[1]]$selpercent
## [1] 11.7 30.8 31.5 21.0 2.4 0.0
##
## [[1]]$npatients
## [1] 5.742 5.544 4.623 2.694 0.880 0.070
##
## [[1]]$ntox
## [1] 0.272 0.569 0.963 0.804 0.453 0.051
##
## [[1]]$totaltox
## [1] 3.112
##
## [[1]]$totaln
## [1] 19.553
##
## [[1]]$percentstop
## [1] 2.6
##
## [[1]]$poorallocation
## [1] 38.2
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 8.424935
##
## [[1]]$sdduration
## [1] 3.20541
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.7 9.0 0.8 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 4.859 1.805 0.379 0.024 0.000 0.000
##
## [[2]]$ntox
## [1] 1.457 0.742 0.193 0.016 0.000 0.000
##
## [[2]]$totaltox
## [1] 2.408
##
## [[2]]$totaln
## [1] 7.067
##
## [[2]]$percentstop
## [1] 57.5
##
## [[2]]$poorallocation
## [1] 46.7
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 2.751609
##
## [[2]]$sdduration
## [1] 2.127865
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 4.0 6.0 11.5 23.8 30.8 20.3
##
## [[3]]$npatients
## [1] 5.712 5.566 5.287 4.899 4.072 2.412
##
## [[3]]$ntox
## [1] 0.303 0.345 0.423 0.536 0.772 0.762
##
## [[3]]$totaltox
## [1] 3.141
##
## [[3]]$totaln
## [1] 27.948
##
## [[3]]$percentstop
## [1] 3.5
##
## [[3]]$poorallocation
## [1] 44.6
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 12.32396
##
## [[3]]$sdduration
## [1] 4.109498
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 8.0 13.4 22.8 38.1 12.9 0.1
##
## [[4]]$npatients
## [1] 5.725 5.444 4.961 4.037 2.237 0.391
##
## [[4]]$ntox
## [1] 0.361 0.462 0.605 0.740 0.879 0.270
##
## [[4]]$totaltox
## [1] 3.317
##
## [[4]]$totaln
## [1] 22.795
##
## [[4]]$percentstop
## [1] 4.7
##
## [[4]]$poorallocation
## [1] 44.1
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 9.918937
##
## [[4]]$sdduration
## [1] 3.7623
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.5 3.4 12.2 32.2 50.3
##
## [[5]]$npatients
## [1] 5.697 5.667 5.750 5.689 5.417 4.285
##
## [[5]]$ntox
## [1] 0.000 0.000 0.195 0.288 0.575 0.961
##
## [[5]]$totaltox
## [1] 2.019
##
## [[5]]$totaln
## [1] 32.505
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 47.4
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 14.36321
##
## [[5]]$sdduration
## [1] 2.47282
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 36 1 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 36 1 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 36 1 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 36 1 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 36 1 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.uni.21.c3
## [[1]]
## [[1]]$selpercent
## [1] 11.4 28.3 31.7 21.0 3.2 0.0
##
## [[1]]$npatients
## [1] 5.154 5.205 4.830 3.309 1.341 0.141
##
## [[1]]$ntox
## [1] 0.272 0.560 0.962 0.979 0.661 0.103
##
## [[1]]$totaltox
## [1] 3.537
##
## [[1]]$totaln
## [1] 19.98
##
## [[1]]$percentstop
## [1] 4.3
##
## [[1]]$poorallocation
## [1] 29.2
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 21.34453
##
## [[1]]$sdduration
## [1] 8.425773
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 30.7 10.1 1.2 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 5.247 2.355 0.594 0.063 0.000 0.000
##
## [[2]]$ntox
## [1] 1.545 0.929 0.307 0.038 0.000 0.000
##
## [[2]]$totaltox
## [1] 2.819
##
## [[2]]$totaln
## [1] 8.259
##
## [[2]]$percentstop
## [1] 58
##
## [[2]]$poorallocation
## [1] 25.1
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 8.40836
##
## [[2]]$sdduration
## [1] 5.627021
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 5.1 5.8 11.6 21.6 32.7 18.3
##
## [[3]]$npatients
## [1] 5.118 4.920 4.788 4.665 4.272 2.745
##
## [[3]]$ntox
## [1] 0.276 0.315 0.375 0.538 0.796 0.974
##
## [[3]]$totaltox
## [1] 3.274
##
## [[3]]$totaln
## [1] 26.508
##
## [[3]]$percentstop
## [1] 3.6
##
## [[3]]$poorallocation
## [1] 35.5
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 28.30546
##
## [[3]]$sdduration
## [1] 9.57304
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 9.3 13.7 21.6 39.4 11.2 0.4
##
## [[4]]$npatients
## [1] 5.148 5.163 4.719 4.350 2.955 0.549
##
## [[4]]$ntox
## [1] 0.321 0.455 0.576 0.806 1.196 0.382
##
## [[4]]$totaltox
## [1] 3.736
##
## [[4]]$totaln
## [1] 22.884
##
## [[4]]$percentstop
## [1] 4.2
##
## [[4]]$poorallocation
## [1] 33.5
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 24.21912
##
## [[4]]$sdduration
## [1] 9.189805
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.1 3.5 12.9 28.4 53.1
##
## [[5]]$npatients
## [1] 4.932 4.917 5.007 5.130 5.304 4.437
##
## [[5]]$ntox
## [1] 0.000 0.000 0.164 0.273 0.608 0.945
##
## [[5]]$totaltox
## [1] 1.99
##
## [[5]]$totaln
## [1] 29.727
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 39.2
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 31.34201
##
## [[5]]$sdduration
## [1] 6.379508
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.uni.14.c3
## [[1]]
## [[1]]$selpercent
## [1] 11.1 27.5 34.0 20.4 3.1 0.1
##
## [[1]]$npatients
## [1] 5.688 5.526 4.911 3.183 1.131 0.123
##
## [[1]]$ntox
## [1] 0.312 0.596 0.959 0.927 0.551 0.087
##
## [[1]]$totaltox
## [1] 3.432
##
## [[1]]$totaln
## [1] 20.562
##
## [[1]]$percentstop
## [1] 3.8
##
## [[1]]$poorallocation
## [1] 23.7
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 11.96221
##
## [[1]]$sdduration
## [1] 4.458119
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.0 9.9 0.4 0.1 0.0 0.0
##
## [[2]]$npatients
## [1] 5.397 2.244 0.501 0.021 0.003 0.000
##
## [[2]]$ntox
## [1] 1.573 0.885 0.283 0.009 0.002 0.000
##
## [[2]]$totaltox
## [1] 2.752
##
## [[2]]$totaln
## [1] 8.166
##
## [[2]]$percentstop
## [1] 57.6
##
## [[2]]$poorallocation
## [1] 20.1
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 4.429341
##
## [[2]]$sdduration
## [1] 2.971743
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 4.7 7.5 11.6 21.6 32.5 17.5
##
## [[3]]$npatients
## [1] 5.631 5.526 5.274 4.869 4.245 2.604
##
## [[3]]$ntox
## [1] 0.321 0.355 0.425 0.549 0.792 0.917
##
## [[3]]$totaltox
## [1] 3.359
##
## [[3]]$totaln
## [1] 28.149
##
## [[3]]$percentstop
## [1] 3
##
## [[3]]$poorallocation
## [1] 33.2
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 16.81818
##
## [[3]]$sdduration
## [1] 5.451822
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 9.8 13.0 21.8 38.0 12.9 0.1
##
## [[4]]$npatients
## [1] 5.679 5.475 4.956 4.212 2.637 0.540
##
## [[4]]$ntox
## [1] 0.376 0.496 0.606 0.769 1.042 0.371
##
## [[4]]$totaltox
## [1] 3.66
##
## [[4]]$totaln
## [1] 23.499
##
## [[4]]$percentstop
## [1] 4.4
##
## [[4]]$poorallocation
## [1] 34
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 13.84291
##
## [[4]]$sdduration
## [1] 5.244291
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.5 3.1 12.8 30.9 50.1
##
## [[5]]$npatients
## [1] 5.619 5.628 5.616 5.595 5.508 4.575
##
## [[5]]$ntox
## [1] 0.000 0.000 0.176 0.256 0.618 0.994
##
## [[5]]$totaltox
## [1] 2.044
##
## [[5]]$totaln
## [1] 32.541
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 31.5
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 19.32238
##
## [[5]]$sdduration
## [1] 3.524605
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.uni.7.c3
## [[1]]
## [[1]]$selpercent
## [1] 11.4 27.4 35.8 19.6 2.2 0.0
##
## [[1]]$npatients
## [1] 5.898 5.646 4.887 3.093 1.041 0.087
##
## [[1]]$ntox
## [1] 0.309 0.593 0.931 0.985 0.513 0.059
##
## [[1]]$totaltox
## [1] 3.39
##
## [[1]]$totaln
## [1] 20.652
##
## [[1]]$percentstop
## [1] 3.6
##
## [[1]]$poorallocation
## [1] 23.3
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 8.89228
##
## [[1]]$sdduration
## [1] 3.382976
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 33.0 8.7 0.9 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 5.322 2.127 0.438 0.039 0.000 0.000
##
## [[2]]$ntox
## [1] 1.616 0.875 0.226 0.027 0.000 0.000
##
## [[2]]$totaltox
## [1] 2.744
##
## [[2]]$totaln
## [1] 7.926
##
## [[2]]$percentstop
## [1] 57.4
##
## [[2]]$poorallocation
## [1] 22.6
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 3.084729
##
## [[2]]$sdduration
## [1] 2.166611
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 5.0 8.7 9.9 22.3 33.9 15.2
##
## [[3]]$npatients
## [1] 5.889 5.598 5.274 4.764 4.143 2.544
##
## [[3]]$ntox
## [1] 0.327 0.355 0.459 0.499 0.772 0.906
##
## [[3]]$totaltox
## [1] 3.318
##
## [[3]]$totaln
## [1] 28.212
##
## [[3]]$percentstop
## [1] 4.7
##
## [[3]]$poorallocation
## [1] 34.5
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 12.53497
##
## [[3]]$sdduration
## [1] 4.535088
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 9.1 12.6 23.3 39.7 10.7 0.0
##
## [[4]]$npatients
## [1] 5.832 5.577 5.061 4.263 2.505 0.426
##
## [[4]]$ntox
## [1] 0.365 0.476 0.628 0.801 1.000 0.305
##
## [[4]]$totaltox
## [1] 3.575
##
## [[4]]$totaln
## [1] 23.664
##
## [[4]]$percentstop
## [1] 4.4
##
## [[4]]$poorallocation
## [1] 32.4
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 10.29353
##
## [[4]]$sdduration
## [1] 3.829018
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 0.8 2.9 13.3 30.8 51.6
##
## [[5]]$npatients
## [1] 5.844 5.835 5.880 5.838 5.625 4.644
##
## [[5]]$ntox
## [1] 0.000 0.000 0.186 0.296 0.624 1.000
##
## [[5]]$totaltox
## [1] 2.106
##
## [[5]]$totaln
## [1] 33.666
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 28.3
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 14.98298
##
## [[5]]$sdduration
## [1] 2.449478
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.wei.21.c3
## [[1]]
## [[1]]$selpercent
## [1] 12.1 27.3 32.6 23.0 1.7 0.0
##
## [[1]]$npatients
## [1] 5.157 5.340 4.869 3.300 1.380 0.093
##
## [[1]]$ntox
## [1] 0.248 0.558 0.969 0.997 0.692 0.066
##
## [[1]]$totaltox
## [1] 3.53
##
## [[1]]$totaln
## [1] 20.139
##
## [[1]]$percentstop
## [1] 3.3
##
## [[1]]$poorallocation
## [1] 28.6
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 21.52665
##
## [[1]]$sdduration
## [1] 8.146225
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.6 9.5 0.8 0.1 0.0 0.0
##
## [[2]]$npatients
## [1] 5.319 2.451 0.618 0.051 0.003 0.000
##
## [[2]]$ntox
## [1] 1.609 0.985 0.311 0.034 0.003 0.000
##
## [[2]]$totaltox
## [1] 2.942
##
## [[2]]$totaln
## [1] 8.442
##
## [[2]]$percentstop
## [1] 57
##
## [[2]]$poorallocation
## [1] 22.7
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 8.719037
##
## [[2]]$sdduration
## [1] 5.71651
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 4.8 7.4 11.5 22.9 30.7 18.7
##
## [[3]]$npatients
## [1] 5.082 5.157 4.887 4.653 4.251 2.754
##
## [[3]]$ntox
## [1] 0.254 0.332 0.413 0.532 0.798 0.935
##
## [[3]]$totaltox
## [1] 3.264
##
## [[3]]$totaln
## [1] 26.784
##
## [[3]]$percentstop
## [1] 2.5
##
## [[3]]$poorallocation
## [1] 36.4
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 28.84125
##
## [[3]]$sdduration
## [1] 9.263002
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 8.1 11.5 24.0 38.3 13.5 0.4
##
## [[4]]$npatients
## [1] 5.100 5.010 4.830 4.443 2.937 0.633
##
## [[4]]$ntox
## [1] 0.295 0.432 0.547 0.870 1.150 0.451
##
## [[4]]$totaltox
## [1] 3.745
##
## [[4]]$totaln
## [1] 22.953
##
## [[4]]$percentstop
## [1] 4.2
##
## [[4]]$poorallocation
## [1] 32.5
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 24.6547
##
## [[4]]$sdduration
## [1] 8.815579
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.1 3.2 13.5 29.1 52.0
##
## [[5]]$npatients
## [1] 4.926 4.899 5.043 5.037 5.322 4.410
##
## [[5]]$ntox
## [1] 0.000 0.000 0.158 0.268 0.592 0.987
##
## [[5]]$totaltox
## [1] 2.005
##
## [[5]]$totaln
## [1] 29.637
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 40
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 31.46151
##
## [[5]]$sdduration
## [1] 6.403053
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.wei.14.c3
## [[1]]
## [[1]]$selpercent
## [1] 10.7 27.5 32.8 22.7 2.2 0.0
##
## [[1]]$npatients
## [1] 5.667 5.544 4.851 3.225 1.194 0.084
##
## [[1]]$ntox
## [1] 0.305 0.556 0.951 0.952 0.615 0.060
##
## [[1]]$totaltox
## [1] 3.439
##
## [[1]]$totaln
## [1] 20.565
##
## [[1]]$percentstop
## [1] 4.1
##
## [[1]]$poorallocation
## [1] 24.7
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 12.07709
##
## [[1]]$sdduration
## [1] 4.588753
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.5 7.9 1.2 0.1 0.0 0.0
##
## [[2]]$npatients
## [1] 5.283 2.115 0.441 0.057 0.006 0.000
##
## [[2]]$ntox
## [1] 1.607 0.884 0.210 0.035 0.003 0.000
##
## [[2]]$totaltox
## [1] 2.739
##
## [[2]]$totaln
## [1] 7.902
##
## [[2]]$percentstop
## [1] 58.3
##
## [[2]]$poorallocation
## [1] 23.9
##
## [[2]]$overdose50
## [1] 0.1
##
## [[2]]$overdose60
## [1] 0.1
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 4.290432
##
## [[2]]$sdduration
## [1] 2.975686
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 5.1 8.5 11.3 22.7 31.3 16.6
##
## [[3]]$npatients
## [1] 5.643 5.544 5.178 4.785 4.077 2.544
##
## [[3]]$ntox
## [1] 0.297 0.364 0.442 0.550 0.782 0.883
##
## [[3]]$totaltox
## [1] 3.318
##
## [[3]]$totaln
## [1] 27.771
##
## [[3]]$percentstop
## [1] 3.6
##
## [[3]]$poorallocation
## [1] 36.6
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 16.44652
##
## [[3]]$sdduration
## [1] 5.615527
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 8.3 13.9 20.7 41.2 11.3 0.0
##
## [[4]]$npatients
## [1] 5.706 5.487 4.989 4.248 2.685 0.441
##
## [[4]]$ntox
## [1] 0.340 0.460 0.608 0.768 1.108 0.317
##
## [[4]]$totaltox
## [1] 3.601
##
## [[4]]$totaln
## [1] 23.556
##
## [[4]]$percentstop
## [1] 4.6
##
## [[4]]$poorallocation
## [1] 33.7
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 13.85909
##
## [[4]]$sdduration
## [1] 5.1416
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.4 2.7 13.6 29.1 51.9
##
## [[5]]$npatients
## [1] 5.625 5.631 5.643 5.637 5.535 4.581
##
## [[5]]$ntox
## [1] 0.000 0.000 0.194 0.277 0.657 1.008
##
## [[5]]$totaltox
## [1] 2.136
##
## [[5]]$totaln
## [1] 32.652
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 30.4
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 19.20339
##
## [[5]]$sdduration
## [1] 3.460889
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
c.wei.7.c3
## [[1]]
## [[1]]$selpercent
## [1] 11.7 30.7 31.4 20.2 2.3 0.0
##
## [[1]]$npatients
## [1] 5.853 5.637 4.800 2.868 1.050 0.081
##
## [[1]]$ntox
## [1] 0.312 0.596 0.987 0.864 0.518 0.058
##
## [[1]]$totaltox
## [1] 3.335
##
## [[1]]$totaln
## [1] 20.289
##
## [[1]]$percentstop
## [1] 3.7
##
## [[1]]$poorallocation
## [1] 25.3
##
## [[1]]$overdose50
## [1] 0
##
## [[1]]$overdose60
## [1] 0
##
## [[1]]$overdose80
## [1] 0
##
## [[1]]$duration
## [1] 8.741867
##
## [[1]]$sdduration
## [1] 3.30933
##
## [[1]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.10 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.20 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.50 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.70 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[1]]$flowchart
## [1] TRUE
##
##
## [[2]]
## [[2]]$selpercent
## [1] 32.0 8.4 0.7 0.0 0.0 0.0
##
## [[2]]$npatients
## [1] 5.316 2.055 0.402 0.027 0.000 0.000
##
## [[2]]$ntox
## [1] 1.598 0.839 0.208 0.016 0.000 0.000
##
## [[2]]$totaltox
## [1] 2.661
##
## [[2]]$totaln
## [1] 7.8
##
## [[2]]$percentstop
## [1] 58.9
##
## [[2]]$poorallocation
## [1] 22.8
##
## [[2]]$overdose50
## [1] 0
##
## [[2]]$overdose60
## [1] 0
##
## [[2]]$overdose80
## [1] 0
##
## [[2]]$duration
## [1] 3.007976
##
## [[2]]$sdduration
## [1] 2.125971
##
## [[2]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.30 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.52 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.61 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.76 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.87 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[2]]$flowchart
## [1] TRUE
##
##
## [[3]]
## [[3]]$selpercent
## [1] 5.6 9.5 10.1 23.5 32.3 15.9
##
## [[3]]$npatients
## [1] 5.895 5.715 5.394 4.815 4.113 2.514
##
## [[3]]$ntox
## [1] 0.297 0.355 0.485 0.540 0.772 0.868
##
## [[3]]$totaltox
## [1] 3.317
##
## [[3]]$totaln
## [1] 28.446
##
## [[3]]$percentstop
## [1] 2.4
##
## [[3]]$poorallocation
## [1] 35.5
##
## [[3]]$overdose50
## [1] 0
##
## [[3]]$overdose60
## [1] 0
##
## [[3]]$overdose80
## [1] 0
##
## [[3]]$duration
## [1] 12.59934
##
## [[3]]$sdduration
## [1] 4.296612
##
## [[3]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.19 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.34 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[3]]$flowchart
## [1] TRUE
##
##
## [[4]]
## [[4]]$selpercent
## [1] 7.4 14.7 21.9 40.0 12.2 0.2
##
## [[4]]$npatients
## [1] 5.871 5.616 5.181 4.227 2.625 0.486
##
## [[4]]$ntox
## [1] 0.348 0.430 0.642 0.761 1.049 0.335
##
## [[4]]$totaltox
## [1] 3.565
##
## [[4]]$totaln
## [1] 24.006
##
## [[4]]$percentstop
## [1] 3.5
##
## [[4]]$poorallocation
## [1] 33.8
##
## [[4]]$overdose50
## [1] 0
##
## [[4]]$overdose60
## [1] 0
##
## [[4]]$overdose80
## [1] 0
##
## [[4]]$duration
## [1] 10.45852
##
## [[4]]$sdduration
## [1] 3.754993
##
## [[4]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.06 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.08 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.12 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.18 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.40 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.71 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[4]]$flowchart
## [1] TRUE
##
##
## [[5]]
## [[5]]$selpercent
## [1] 0.0 1.6 3.0 11.9 31.3 50.8
##
## [[5]]$npatients
## [1] 5.844 5.874 5.850 5.808 5.574 4.707
##
## [[5]]$ntox
## [1] 0.000 0.000 0.187 0.276 0.582 1.026
##
## [[5]]$totaltox
## [1] 2.071
##
## [[5]]$totaln
## [1] 33.657
##
## [[5]]$percentstop
## [1] 0
##
## [[5]]$poorallocation
## [1] 26.7
##
## [[5]]$overdose50
## [1] 0
##
## [[5]]$overdose60
## [1] 0
##
## [[5]]$overdose80
## [1] 0
##
## [[5]]$duration
## [1] 14.97586
##
## [[5]]$sdduration
## [1] 2.611955
##
## [[5]]$simu.setup
## target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
## 1 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 2 0.2 0.00 12 3 1 0.15 0.25 0.95 FALSE
## 3 0.2 0.03 12 3 1 0.15 0.25 0.95 FALSE
## 4 0.2 0.05 12 3 1 0.15 0.25 0.95 FALSE
## 5 0.2 0.11 12 3 1 0.15 0.25 0.95 FALSE
## 6 0.2 0.22 12 3 1 0.15 0.25 0.95 FALSE
## offset ntrial dose
## 1 0.05 1000 1
## 2 0.05 1000 2
## 3 0.05 1000 3
## 4 0.05 1000 4
## 5 0.05 1000 5
## 6 0.05 1000 6
##
## [[5]]$flowchart
## [1] TRUE
result
setwd("C:/paper_exponential")
library(erer)
## 필요한 패키지를 로딩중입니다: lmtest
## 필요한 패키지를 로딩중입니다: zoo
##
## 다음의 패키지를 부착합니다: 'zoo'
## The following objects are masked from 'package:base':
##
## as.Date, as.Date.numeric
## Registered S3 method overwritten by 'quantmod':
## method from
## as.zoo.data.frame zoo
write.list(c.uni.21.c1, file = "r3_uni_21_c1.csv")
write.list(c.uni.14.c1, file = "r3_uni_14_c1.csv")
write.list(c.uni.7.c1, file = "r3_uni_7_c1.csv")
write.list(c.wei.21.c1, file = "r3_wei_21_c1.csv")
write.list(c.wei.14.c1, file = "r3_wei_14_c1.csv")
write.list(c.wei.7.c1, file = "r3_wei_7_c1.csv")
write.list(c.uni.21.c3, file = "r3_uni_21_c3.csv")
write.list(c.uni.14.c3, file = "r3_uni_14_c3.csv")
write.list(c.uni.7.c3, file = "r3_uni_7_c3.csv")
write.list(c.wei.21.c3, file = "r3_wei_21_c3.csv")
write.list(c.wei.14.c3, file = "r3_wei_14_c3.csv")
write.list(c.wei.7.c3, file = "r3_wei_7_c3.csv")