1 Surowe wyniki pomiarów ciśnienia śródgałkowego (IOP) w oku prawym (OD) i lewym (OS) w ostatnich kilku dobach

Raw IOP measurements in the right (OD) and left (OS) eye over the last few days

2 Ciśnienie w oku prawym i lewym z wygładzonym wahaniem dobowym

Smoothed IOP curves for both eyes

3 Różnica ciśnienia między prawym a lewym okiem

Right minus left eye IOP difference
19.11 zamieniono oczami (1) NodoFreeCombi i (2) TimoComod + Azopt
Treatment crossed over between eyes on Nov. 19
2.12 OS bez zmian NodoFree Combi, w OD zmiana na Vizitrav + NodoFree Combi
Dec 2nd OD stays on NodoFree Combi, OS switched to Vizitrav + NodoFree Combi

4 Model z uwzględnieniem pory dnia, schematu leczniczego i oka

Polynomial model with hour of the day, treatment and eye as predictors

4.1 Parametry modelu

Poziom odniesienia to oko prawe (OD), NodoFree Combi
Model parameters with right eye and NodoFree Combi as reference levels

## 
## Call:
## lm(formula = IOP ~ Eye + Treatment + poly(Hour, 5), data = IOP[IOP$Date > 
##     from, ])
## 
## Residuals:
##     Min      1Q  Median      3Q     Max 
## -8.0495 -2.3407 -0.1708  2.1987  9.6312 
## 
## Coefficients:
##                          Estimate Std. Error t value Pr(>|t|)    
## (Intercept)               17.5164     0.3708  47.238  < 2e-16 ***
## EyeOS                     -1.9598     0.3739  -5.242 2.42e-07 ***
## TreatmentTimo+Azopt        0.4291     0.3880   1.106  0.26931    
## TreatmentTravo+NodoCombi  -4.1726     0.4895  -8.524  < 2e-16 ***
## poly(Hour, 5)1           -19.8832     3.1839  -6.245 9.61e-10 ***
## poly(Hour, 5)2             5.3643     3.1839   1.685  0.09270 .  
## poly(Hour, 5)3           -10.3440     3.1863  -3.246  0.00125 ** 
## poly(Hour, 5)4           -31.9146     3.1861 -10.017  < 2e-16 ***
## poly(Hour, 5)5            10.3096     3.1891   3.233  0.00131 ** 
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## Residual standard error: 3.184 on 463 degrees of freedom
## Multiple R-squared:  0.3942, Adjusted R-squared:  0.3837 
## F-statistic: 37.66 on 8 and 463 DF,  p-value: < 2.2e-16
## Anova Table (Type II tests)
## 
## Response: IOP
##               Sum Sq  Df F value    Pr(>F)    
## Eye            278.5   1  27.479 2.418e-07 ***
## Treatment     1175.7   2  57.997 < 2.2e-16 ***
## poly(Hour, 5) 1653.1   5  32.619 < 2.2e-16 ***
## Residuals     4692.9 463                      
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

4.2 Wykresy efektów oka i schematu leczniczego

Effect plots

4.3 Wykres efektu pory dnia

5 Dobowe maksima, minima i wartości środkowe

Daily maximum, minimum, and mid-range

6 Modele liniowe dla wartości dobowych

Linear models for daily values
Poziom odniesienia to oko prawe (OD), NodoFree Combi
Reference levels are for right eye and NodoFree Combi

6.1 Dobowe wartości środkowe (między maksimum i minimum)

Daily mid-range values (between max and min)

## 
## Call:
## lm(formula = IOP.day.mid ~ Eye + Treatment, data = daily.s)
## 
## Residuals:
##     Min      1Q  Median      3Q     Max 
## -3.4720 -0.9069  0.1147  1.0837  3.1147 
## 
## Coefficients:
##                          Estimate Std. Error t value Pr(>|t|)    
## (Intercept)              17.97195    0.41706  43.092  < 2e-16 ***
## EyeOS                    -1.74698    0.43239  -4.040 0.000164 ***
## TreatmentTimo+Azopt      -0.08669    0.44749  -0.194 0.847097    
## TreatmentTravo+NodoCombi -4.55562    0.62508  -7.288 1.16e-09 ***
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## Residual standard error: 1.484 on 56 degrees of freedom
## Multiple R-squared:  0.5412, Adjusted R-squared:  0.5167 
## F-statistic: 22.02 on 3 and 56 DF,  p-value: 1.51e-09

6.2 Dobowe wartości minimalne

Daily minimum

## 
## Call:
## lm(formula = IOP.day.min ~ Eye + Treatment, data = daily.s)
## 
## Residuals:
##     Min      1Q  Median      3Q     Max 
## -2.6282 -0.9558 -0.0257  1.0442  3.3718 
## 
## Coefficients:
##                          Estimate Std. Error t value Pr(>|t|)    
## (Intercept)               12.1949     0.4068  29.981  < 2e-16 ***
## EyeOS                     -1.6025     0.4217  -3.800 0.000359 ***
## TreatmentTimo+Azopt        0.4333     0.4364   0.993 0.325084    
## TreatmentTravo+NodoCombi  -3.2391     0.6096  -5.313 1.93e-06 ***
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## Residual standard error: 1.447 on 56 degrees of freedom
## Multiple R-squared:  0.4565, Adjusted R-squared:  0.4274 
## F-statistic: 15.68 on 3 and 56 DF,  p-value: 1.604e-07

6.3 Dobowe wartości maksymalne

Daily maximum

## 
## Call:
## lm(formula = IOP.day.max ~ Eye + Treatment, data = daily.s)
## 
## Residuals:
##     Min      1Q  Median      3Q     Max 
## -4.7490 -0.8623  0.1425  1.1425  4.2510 
## 
## Coefficients:
##                          Estimate Std. Error t value Pr(>|t|)    
## (Intercept)               23.7490     0.6129  38.752  < 2e-16 ***
## EyeOS                     -1.8915     0.6354  -2.977  0.00429 ** 
## TreatmentTimo+Azopt       -0.6067     0.6576  -0.923  0.36019    
## TreatmentTravo+NodoCombi  -5.8722     0.9185  -6.393 3.46e-08 ***
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## Residual standard error: 2.18 on 56 degrees of freedom
## Multiple R-squared:  0.4462, Adjusted R-squared:  0.4165 
## F-statistic: 15.04 on 3 and 56 DF,  p-value: 2.689e-07

7 Efekt obniżenia ciśnienia śródgałkowego po ćwiczeniu: bezpośrednio po 10-minutowej jeździe rowerem, umiarkowany wysiłek

IOP drop and return to baseline following 10-minute moderate cycling