## 
## postnatal  prenatal 
##        36        74

summary of data

#summary of all cases by timescale
tbl_summary(df[,c(2,6:23)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 371 early, N = 481 F, N = 251 p-value2
elongation.of.CP <0.001
N 15 (41%) 15 (31%) 2 (8.0%)
U 0 (0%) 3 (6.2%) 23 (92%)
Y 22 (59%) 30 (62%) 0 (0%)
Deformation.of.Pit.gland 0 (0%) 0 (0%) 0 (0%)
Unknown 0 2 24
TVFB 0.009
0 35 (97%) 39 (85%) 0 (NA%)
1 0 (0%) 7 (15%) 0 (NA%)
2.1 1 (2.8%) 0 (0%) 0 (NA%)
Unknown 1 2 25
Bowing.of.LT 5 (14%) 9 (20%) 0 (NA%) 0.6
Unknown 2 3 25
Aqueductal.Stenosis 9 (30%) 9 (24%) 0 (NA%) 0.8
Unknown 7 11 25
Ratio.of.2.planes.AP 46 (41, 51) 40 (37, 46) 20 (17, 24) <0.001
Unknown 0 0 18
Ratio.of.2.planes.within.Lat.ventricle.SI 12.1 (9.0, 16.2) 10.2 (7.3, 13.2) 3.7 (3.3, 4.2) <0.001
Unknown 0 0 18
Thickness.of.CC 1.70 (1.30, 2.20) 2.20 (1.50, 3.00) 1.50 (1.10, 1.80) 0.006
Unknown 0 1 18
Chiari 0 (0, 5) 2 (0, 14) 9 (6, 11) 0.003
Unknown 0 1 5
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 17.0 (15.3, 20.0) 16.0 (14.1, 18.1) 6.3 (6.0, 7.4) <0.001
Unknown 0 0 3
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 43 (38, 56) 39 (33, 47) 21 (19, 26) <0.001
Unknown 0 0 3
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.00 (2.20, 5.00) 1.90 (1.30, 2.50) 0.00 (0.00, 0.00) <0.001
Unknown 0 0 3
cortical.thickness 17.0 (15.3, 20.0) 16.0 (14.1, 18.1) 6.3 (6.0, 7.4) <0.001
Unknown 0 0 3
elongation.of.CP.Glomus 3.00 (2.30, 3.80) 3.00 (2.40, 3.30) 2.60 (2.60, 2.60) 0.8
Unknown 0 0 24
Elongation.of.CP.body 1.50 (1.20, 1.70) 1.50 (1.10, 2.00) NA (NA, NA) 0.5
Unknown 0 1 25
Transependymal.Flow 0 (0%) 0 (0%) 0 (0%)
Unknown 0 0 10
Width.of.L.Atrium 21 (16, 30) 20 (16, 28) 12 (10, 14) <0.001
Unknown 0 0 2
Width.of.R.atrium 17 (14, 27) 18 (14, 23) 12 (10, 14) <0.001
Unknown 0 0 2
1 n (%); Median (IQR)
2 Pearson's Chi-squared test; Fisher's exact test; Kruskal-Wallis rank sum test 
#summary of all cases with NA removed by timescale  
tbl_summary(df2[,c(2,6:23)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 301 early, N = 331 p-value2
elongation.of.CP 0.6
N 13 (43%) 12 (36%)
Y 17 (57%) 21 (64%)
Deformation.of.Pit.gland 0 (0%) 0 (0%)
TVFB 0.11
0 29 (97%) 29 (88%)
1 0 (0%) 4 (12%)
2.1 1 (3.3%) 0 (0%)
Bowing.of.LT 4 (13%) 6 (18%) 0.7
Aqueductal.Stenosis 9 (30%) 6 (18%) 0.3
Ratio.of.2.planes.AP 47 (43, 51) 39 (37, 44) <0.001
Ratio.of.2.planes.within.Lat.ventricle.SI 12.2 (9.2, 15.4) 9.7 (6.8, 12.3) 0.029
Thickness.of.CC 1.75 (1.23, 2.15) 2.20 (1.70, 3.00) 0.016
Chiari 0 (0, 9) 4 (0, 15) 0.2
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 17.4 (15.4, 20.0) 16.4 (15.4, 18.4) 0.4
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 43 (37, 55) 36 (33, 44) 0.011
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.35 (2.28, 5.00) 1.70 (1.30, 2.30) <0.001
cortical.thickness 17.4 (15.4, 20.0) 16.4 (15.4, 18.4) 0.4
elongation.of.CP.Glomus 3.05 (2.30, 4.00) 3.00 (2.50, 3.30) 0.5
Elongation.of.CP.body 1.50 (1.30, 1.60) 1.70 (1.30, 2.00) 0.14
Transependymal.Flow 0 (0%) 0 (0%)
Width.of.L.Atrium 20 (14, 29) 18 (15, 25) 0.4
Width.of.R.atrium 16 (13, 25) 16 (14, 21) 0.7
1 n (%); Median (IQR)
2 Pearson's Chi-squared test; Fisher's exact test; Wilcoxon rank sum test 
#summary of all cases by pre/postnatal
tbl_summary(df[,c(6:24)],label = `prepost` ~ "Neuroradiologic Findings",by="prepost")%>%
  bold_labels()  %>%add_p()
Characteristic postnatal, N = 361 prenatal, N = 741 p-value2
elongation.of.CP 0.001
N 9 (25%) 23 (31%)
U 2 (5.6%) 24 (32%)
Y 25 (69%) 27 (36%)
Deformation.of.Pit.gland 0 (0%) 0 (0%)
Unknown 1 25
TVFB >0.9
0 33 (92%) 41 (89%)
1 3 (8.3%) 4 (8.7%)
2.1 0 (0%) 1 (2.2%)
Unknown 0 28
Bowing.of.LT 8 (22%) 6 (14%) 0.4
Unknown 0 30
Aqueductal.Stenosis 8 (24%) 10 (29%) 0.6
Unknown 3 40
Ratio.of.2.planes.AP 45 (40, 51) 41 (34, 47) 0.021
Unknown 0 18
Ratio.of.2.planes.within.Lat.ventricle.SI 12.5 (10.6, 15.7) 7.9 (5.2, 12.6) <0.001
Unknown 0 18
Thickness.of.CC 1.95 (1.30, 3.00) 1.90 (1.50, 2.50) 0.7
Unknown 0 19
Chiari 14 (2, 19) 0 (0, 5) <0.001
Unknown 0 6
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 15.6 (13.8, 17.3) 15.0 (8.0, 19.0) 0.4
Unknown 0 3
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 43 (38, 57) 34 (26, 43) <0.001
Unknown 0 3
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 2.00 (1.50, 4.12) 1.70 (0.00, 3.00) 0.021
Unknown 0 3
cortical.thickness 15.6 (13.8, 17.3) 15.0 (8.0, 19.0) 0.4
Unknown 0 3
elongation.of.CP.Glomus 3.00 (2.20, 3.33) 3.05 (2.33, 3.50) 0.5
Unknown 0 24
Elongation.of.CP.body 1.50 (1.28, 1.85) 1.45 (1.08, 2.00) >0.9
Unknown 0 26
Transependymal.Flow 0 (0%) 0 (0%)
Unknown 0 10
Width.of.L.Atrium 23 (16, 31) 15 (12, 23) <0.001
Unknown 0 2
Width.of.R.atrium 19 (15, 26) 15 (12, 18) <0.001
Unknown 0 2
1 n (%); Median (IQR)
2 Pearson's Chi-squared test; Fisher's exact test; Wilcoxon rank sum test 
#summary of all prenatal cases by timescale    
tbl_summary(df_pre[,c(2,6:23)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 231 early, N = 261 F, N = 251 p-value2
elongation.of.CP <0.001
N 11 (48%) 10 (38%) 2 (8.0%)
U 0 (0%) 1 (3.8%) 23 (92%)
Y 12 (52%) 15 (58%) 0 (0%)
Deformation.of.Pit.gland 0 (0%) 0 (0%) 0 (0%)
Unknown 0 1 24
TVFB 0.11
0 21 (95%) 20 (83%) 0 (NA%)
1 0 (0%) 4 (17%) 0 (NA%)
2.1 1 (4.5%) 0 (0%) 0 (NA%)
Unknown 1 2 25
Bowing.of.LT 2 (9.5%) 4 (17%) 0 (NA%) 0.7
Unknown 2 3 25
Aqueductal.Stenosis 5 (29%) 5 (29%) 0 (NA%) >0.9
Unknown 6 9 25
Ratio.of.2.planes.AP 44 (41, 48) 39 (35, 46) 20 (17, 24) 0.003
Unknown 0 0 18
Ratio.of.2.planes.within.Lat.ventricle.SI 10.2 (6.7, 14.0) 9.0 (5.6, 12.9) 3.7 (3.3, 4.2) <0.001
Unknown 0 0 18
Thickness.of.CC 1.80 (1.50, 2.15) 2.20 (1.50, 3.00) 1.50 (1.10, 1.80) 0.030
Unknown 0 1 18
Chiari 0.0 (0.0, 0.0) 0.0 (0.0, 0.0) 9.2 (5.8, 11.1) <0.001
Unknown 0 1 5
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 19.1 (15.4, 22.2) 16.5 (14.3, 18.9) 6.3 (6.0, 7.4) <0.001
Unknown 0 0 3
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 43 (36, 51) 35 (32, 46) 21 (19, 26) <0.001
Unknown 0 0 3
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.00 (2.10, 4.85) 1.90 (1.13, 2.80) 0.00 (0.00, 0.00) <0.001
Unknown 0 0 3
cortical.thickness 19.1 (15.4, 22.2) 16.5 (14.3, 18.9) 6.3 (6.0, 7.4) <0.001
Unknown 0 0 3
elongation.of.CP.Glomus 3.20 (2.40, 3.70) 2.85 (2.33, 3.38) 2.60 (2.60, 2.60) 0.6
Unknown 0 0 24
Elongation.of.CP.body 1.40 (1.05, 1.90) 1.50 (1.20, 2.00) NA (NA, NA) 0.6
Unknown 0 1 25
Transependymal.Flow 0 (0%) 0 (0%) 0 (0%)
Unknown 0 0 10
Width.of.L.Atrium 19 (13, 25) 19 (14, 26) 12 (10, 14) <0.001
Unknown 0 0 2
Width.of.R.atrium 17 (14, 21) 16 (13, 25) 12 (10, 14) <0.001
Unknown 0 0 2
1 n (%); Median (IQR)
2 Pearson's Chi-squared test; Fisher's exact test; Kruskal-Wallis rank sum test 
#summary of all postnatal cases by timescale 
tbl_summary(df_post[,c(2,6:23)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 141 early, N = 221 p-value2
elongation.of.CP 0.7
N 4 (29%) 5 (23%)
U 0 (0%) 2 (9.1%)
Y 10 (71%) 15 (68%)
Deformation.of.Pit.gland 0 (0%) 0 (0%)
Unknown 0 1
TVFB 0 (0%) 3 (14%) 0.3
Bowing.of.LT 3 (21%) 5 (23%) >0.9
Aqueductal.Stenosis 4 (31%) 4 (20%) 0.7
Unknown 1 2
Ratio.of.2.planes.AP 50 (44, 52) 42 (38, 45) 0.018
Ratio.of.2.planes.within.Lat.ventricle.SI 15 (12, 17) 12 (10, 13) 0.050
Thickness.of.CC 1.50 (1.20, 2.15) 2.15 (1.55, 3.30) 0.051
Chiari 8 (0, 15) 14 (4, 19) 0.2
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 15.45 (13.57, 17.42) 15.80 (14.05, 17.00) >0.9
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 54 (40, 67) 42 (36, 49) 0.091
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.55 (2.90, 5.15) 1.90 (1.35, 2.00) <0.001
cortical.thickness 15.45 (13.57, 17.42) 15.80 (14.05, 17.00) >0.9
elongation.of.CP.Glomus 2.55 (2.05, 3.88) 3.00 (2.42, 3.30) 0.7
Elongation.of.CP.body 1.50 (1.30, 1.58) 1.50 (1.08, 2.00) 0.7
Transependymal.Flow 0 (0%) 0 (0%)
Width.of.L.Atrium 25 (17, 34) 23 (16, 28) 0.5
Width.of.R.atrium 20 (16, 27) 18 (15, 22) 0.7
1 n (%); Median (IQR)
2 Fisher's exact test; Wilcoxon rank sum test