Updated RShiny link.

1. Summary of covariates

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DFC Imaging Committee Analysis: c-myc study.
Table 1: Descriptive statistics of baseline covariates.
Indiana University
(N=18)		 Stanford University
(N=7)		 UCSF
(N=24)		 University of Arizona
(N=13)		 University of Miami
(N=4)		 University of Michigan
(N=40)		 Overall
(N=106)
Age (as of 2022/10/18) (years)
Mean (SD) 54.8 (11.5) 69.5 (9.98) 55.6 (8.52) 55.6 (9.62) 66.0 (11.8) 57.5 (11.2) 57.5 (10.9)
Median [Min, Max] 54.9 [30.4, 75.5] 68.2 [57.9, 81.9] 58.0 [39.5, 71.4] 55.9 [42.2, 75.9] 67.3 [50.5, 79.1] 59.2 [30.6, 78.6] 58.1 [30.4, 81.9]
Gender
Female 11 (61.1%) 1 (14.3%) 4 (16.7%) 4 (30.8%) 1 (25.0%) 6 (15.0%) 27 (25.5%)
Male 7 (38.9%) 6 (85.7%) 20 (83.3%) 9 (69.2%) 3 (75.0%) 34 (85.0%) 79 (74.5%)
Ethnicity
Hispanic 1 (5.6%) 1 (14.3%) 8 (33.3%) 4 (30.8%) 0 (0%) 0 (0%) 14 (13.2%)
Non-Hispanic 16 (88.9%) 5 (71.4%) 16 (66.7%) 9 (69.2%) 4 (100%) 40 (100%) 90 (84.9%)
Unknown or not reported 1 (5.6%) 1 (14.3%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 2 (1.9%)
Highest level of education
Bachelor's degree (e.g., BA, AB, BS, BBA) 3 (16.7%) 2 (28.6%) 2 (8.3%) 2 (15.4%) 1 (25.0%) 4 (10.0%) 14 (13.2%)
GED or equivalent 1 (5.6%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 2 (5.0%) 3 (2.8%)
High school graduate 6 (33.3%) 0 (0%) 7 (29.2%) 4 (30.8%) 0 (0%) 7 (17.5%) 24 (22.6%)
Master's degree (e.g., MA, MS, MEng, MEd, MBA) 1 (5.6%) 0 (0%) 1 (4.2%) 0 (0%) 0 (0%) 5 (12.5%) 7 (6.6%)
Some college, no degree 1 (5.6%) 1 (14.3%) 8 (33.3%) 6 (46.2%) 2 (50.0%) 16 (40.0%) 34 (32.1%)
Unknown 6 (33.3%) 3 (42.9%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 9 (8.5%)
No diploma 0 (0%) 1 (14.3%) 3 (12.5%) 1 (7.7%) 0 (0%) 1 (2.5%) 6 (5.7%)
Associate degree: academic program 0 (0%) 0 (0%) 1 (4.2%) 0 (0%) 1 (25.0%) 0 (0%) 2 (1.9%)
Associate degree: occupational or technical or vocational program 0 (0%) 0 (0%) 1 (4.2%) 0 (0%) 0 (0%) 3 (7.5%) 4 (3.8%)
Doctoral degree (e.g., PhD, EdD) 0 (0%) 0 (0%) 1 (4.2%) 0 (0%) 0 (0%) 2 (5.0%) 3 (2.8%)
Employment status
Disabled, permanently or temporarily 7 (38.9%) 1 (14.3%) 8 (33.3%) 4 (30.8%) 1 (25.0%) 15 (37.5%) 36 (34.0%)
Looking for work, unemployed 1 (5.6%) 0 (0%) 1 (4.2%) 1 (7.7%) 0 (0%) 1 (2.5%) 4 (3.8%)
Retired 3 (16.7%) 4 (57.1%) 6 (25.0%) 3 (23.1%) 2 (50.0%) 12 (30.0%) 30 (28.3%)
Sick leave or maternity leave 2 (11.1%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 1 (2.5%) 3 (2.8%)
Unknown 2 (11.1%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 2 (1.9%)
Working now 3 (16.7%) 2 (28.6%) 8 (33.3%) 4 (30.8%) 1 (25.0%) 10 (25.0%) 28 (26.4%)
Laid off 0 (0%) 0 (0%) 1 (4.2%) 0 (0%) 0 (0%) 0 (0%) 1 (0.9%)
Keeping house 0 (0%) 0 (0%) 0 (0%) 1 (7.7%) 0 (0%) 0 (0%) 1 (0.9%)
Other 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 1 (2.5%) 1 (0.9%)
Marital status
Divorced 2 (11.1%) 0 (0%) 3 (12.5%) 1 (7.7%) 2 (50.0%) 5 (12.5%) 13 (12.3%)
Married 8 (44.4%) 4 (57.1%) 3 (12.5%) 9 (69.2%) 1 (25.0%) 20 (50.0%) 45 (42.5%)
Never married 5 (27.8%) 2 (28.6%) 14 (58.3%) 2 (15.4%) 0 (0%) 9 (22.5%) 32 (30.2%)
Separated 1 (5.6%) 0 (0%) 1 (4.2%) 0 (0%) 1 (25.0%) 1 (2.5%) 4 (3.8%)
Widowed 2 (11.1%) 1 (14.3%) 1 (4.2%) 1 (7.7%) 0 (0%) 4 (10.0%) 9 (8.5%)
Domestic partner 0 (0%) 0 (0%) 2 (8.3%) 0 (0%) 0 (0%) 1 (2.5%) 3 (2.8%)

Notes: Four individuals not included in table.
1. Missing wound measurements: 06CMY3529.
2. Missing baseline covariates: 01CMY0176, 05CMY2927, 05CMY2934.

2. CRU-level tabular summary of image counts

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CRU # of patients Median # of eKARE readings Median # of SOC readings Median # of matched readings
Indiana University 20 4 9.0 3.5
Stanford University 7 9 10.0 8.0
UCSF 25 9 10.0 8.0
University of Arizona 13 0 5.0 0.0
University of Miami 4 0 3.5 0.0
University of Michigan 40 3 6.0 3.0

3. Patient-level graphical summary of image counts

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4. Patient-level graphical summary of missingness patterns

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5. CRU-level tabular summary of measurements (matched)

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DFC Imaging Committee Analysis: c-myc study.
Table 3A: Summary of measurement (eKARE vs SOC).
Indiana University
Stanford University
UCSF
University of Michigan
Overall
eKARE
(N=96)		 SOC
(N=96)		 eKARE
(N=45)		 SOC
(N=45)		 eKARE
(N=179)		 SOC
(N=179)		 eKARE
(N=129)		 SOC
(N=129)		 eKARE
(N=449)		 SOC
(N=449)
Length (cm)
Mean (SD) 1.78 (1.23) 1.39 (0.900) 1.91 (0.941) 1.82 (1.06) 0.967 (0.750) 1.05 (0.853) 1.44 (0.841) 1.51 (1.00) 1.37 (0.982) 1.33 (0.961)
Median [Min, Max] 1.40 [0, 5.10] 1.20 [0, 5.30] 1.90 [0.400, 4.20] 1.80 [0.500, 5.10] 0.900 [0, 6.00] 0.900 [0, 4.50] 1.40 [0, 4.30] 1.30 [0.100, 5.50] 1.10 [0, 6.00] 1.10 [0, 5.50]
Width (cm)
Mean (SD) 1.76 (1.31) 1.35 (0.997) 1.94 (1.16) 1.55 (1.09) 0.936 (0.682) 0.905 (0.773) 1.58 (1.11) 1.39 (1.05) 1.40 (1.09) 1.20 (0.971)
Median [Min, Max] 1.20 [0, 6.10] 1.05 [0, 4.60] 1.40 [0.500, 5.00] 1.20 [0.300, 5.80] 0.800 [0, 4.60] 0.700 [0, 5.70] 1.40 [0, 5.60] 1.20 [0.100, 5.90] 1.10 [0, 6.10] 1.00 [0, 5.90]
Depth (cm)
Mean (SD) 0.190 (0.333) 0.356 (0.486) 0.213 (0.134) 0.544 (0.437) 0.0732 (0.0825) 0.151 (0.0914) 0.114 (0.133) 0.340 (0.370) 0.124 (0.189) 0.289 (0.357)
Median [Min, Max] 0.100 [0, 2.20] 0.200 [0, 2.80] 0.200 [0, 0.500] 0.400 [0.100, 1.80] 0.100 [0, 0.400] 0.100 [0, 0.500] 0.100 [0, 0.700] 0.300 [0.100, 4.00] 0.100 [0, 2.20] 0.200 [0, 4.00]

Unit of comparison is a given visit, for a given patient.

DFC Imaging Committee Analysis: c-myc study.
Table 3B: Summary of baseline measurement of area (eKARE vs SOC).
Indiana University
Stanford University
UCSF
University of Michigan
Overall
eKARE
(N=16)		 SOC
(N=16)		 eKARE
(N=6)		 SOC
(N=6)		 eKARE
(N=23)		 SOC
(N=23)		 eKARE
(N=32)		 SOC
(N=32)		 eKARE
(N=77)		 SOC
(N=77)
Area (sq. cm)
Mean (SD) 4.61 (4.51) 3.32 (3.12) 3.40 (3.15) 3.78 (5.07) 1.22 (0.959) 1.85 (2.02) 2.40 (1.99) 2.93 (2.55) 2.58 (2.84) 2.75 (2.81)
Median [Min, Max] 3.50 [0.400, 14.7] 2.33 [0.720, 10.6] 2.60 [0.600, 9.00] 1.43 [0.700, 13.8] 1.00 [0.100, 4.10] 1.08 [0.0600, 7.36] 1.70 [0, 7.20] 2.21 [0.320, 10.2] 1.60 [0, 14.7] 1.54 [0.0600, 13.8]

Unit of comparison is a given visit, for a given patient.
SOC calculates wound area by multiplying length and width, whereas eKARE relies on wound segmentation.

6. Comparison of measurements (matched)

6A. Tabular summary of raw and absolute measurement discrepancies (WITHOUT correcting for corelation)

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DFC Imaging Committee Analysis: c-myc study.
Table 4: Summary of measurement discrepancy (eKARE - SOC).
Indiana University
(N=96)		 Stanford University
(N=45)		 UCSF
(N=179)		 University of Michigan
(N=129)		 Overall
(N=449)
Raw area error (eKARE - SOC) (sq. cm)
Mean (SD) 0.622 (2.79) -0.281 (2.33) -0.489 (1.71) -0.569 (1.26) -0.253 (2.00)
Median [Min, Max] 0.175 [-5.84, 10.0] -0.100 [-10.5, 6.10] -0.0600 [-15.0, 0.850] -0.240 [-9.35, 1.02] -0.0800 [-15.0, 10.0]
Absolute area error (eKARE - SOC) (sq. cm)
Mean (SD) 1.61 (2.36) 1.28 (1.96) 0.572 (1.69) 0.732 (1.17) 0.910 (1.80)
Median [Min, Max] 0.560 [0.0100, 10.0] 0.580 [0, 10.5] 0.100 [0, 15.0] 0.360 [0, 9.35] 0.300 [0, 15.0]
Raw length error (eKARE - SOC) (cm)
Mean (SD) 0.389 (0.956) 0.0978 (0.907) -0.0816 (0.402) -0.0701 (0.572) 0.0402 (0.684)
Median [Min, Max] 0.200 [-2.90, 3.20] 0.100 [-2.60, 2.90] 0 [-3.20, 1.50] 0 [-3.40, 1.50] 0 [-3.40, 3.20]
Absolute length error (eKARE - SOC) (cm)
Mean (SD) 0.724 (0.733) 0.560 (0.715) 0.191 (0.363) 0.304 (0.490) 0.374 (0.574)
Median [Min, Max] 0.500 [0, 3.20] 0.200 [0, 2.90] 0.100 [0, 3.20] 0.200 [0, 3.40] 0.200 [0, 3.40]
Raw width error (eKARE - SOC) (cm)
Mean (SD) 0.406 (0.819) 0.391 (0.712) 0.0313 (0.332) 0.189 (0.640) 0.193 (0.614)
Median [Min, Max] 0.300 [-1.80, 3.10] 0.200 [-1.00, 2.30] 0 [-2.30, 1.00] 0.100 [-1.20, 4.80] 0.100 [-2.30, 4.80]
Absolute width error (eKARE - SOC) (cm)
Mean (SD) 0.652 (0.638) 0.582 (0.563) 0.169 (0.287) 0.327 (0.581) 0.359 (0.534)
Median [Min, Max] 0.400 [0, 3.10] 0.400 [0, 2.30] 0.100 [0, 2.30] 0.200 [0, 4.80] 0.200 [0, 4.80]
Raw depth error (eKARE - SOC) (cm)
Mean (SD) -0.167 (0.303) -0.331 (0.393) -0.0777 (0.0951) -0.226 (0.383) -0.165 (0.295)
Median [Min, Max] -0.100 [-1.70, 0.800] -0.200 [-1.40, 0.200] -0.100 [-0.400, 0.200] -0.200 [-4.00, 0.300] -0.100 [-4.00, 0.800]
Absolute depth error (eKARE - SOC) (cm)
Mean (SD) 0.223 (0.263) 0.353 (0.373) 0.0888 (0.0847) 0.243 (0.372) 0.188 (0.280)
Median [Min, Max] 0.100 [0, 1.70] 0.200 [0, 1.40] 0.100 [0, 0.400] 0.200 [0, 4.00] 0.100 [0, 4.00]

Unit of comparison is a given visit, for a given patient.

6B. Graphical summary of raw and absolute measurement discrepancies (WITHOUT correcting for corelation)

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6C. Tabular summary of measurement discrepancies (after correcting for correlation)

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We account for patient-level correlation of repeated discrepancies in measurement (eKARE - SOC) and report mean (95% CI) for measurement discrepancy across all sites.

Area (sq. cm.) Length (cm.) Width (cm.) Depth (cm.)
-0.290 (-0.577, -0.00329) 0.0247 (-0.0771, 0.126) 0.200 (0.118, 0.283) -0.181 (-0.231, -0.131)

References:

  1. Previous report (dated 2022-06-30).
  2. Previous report (dated 2022-07-12).