AATS 2023 Initial
Emily Vianna
2022-10-13
Data Spread
Patient Characteristics
All Patients
Notes:
- check outliers
Notes:
- far fewer control trials than aneurysmal
- 3 patients prior cardiac surgery
By Tissue Type
Notes:
- 2 recipients with “suspicious” genetic history; 11 aneurysm patients no data
- Lots of valvular disease ina neurysmal patients
- High % recipients with CKD, CHF (expected but perhaps explanatory?)
- Aneurysm patients taller and higher weight, but recipients have lowest BMI…?
- Age does not seem to vary much between groups
Characteristic | Aneurysm, N = 1041 | donor, N = 61 | recipient, N = 101 |
disease | |||
Aneurysm | 104 (100%) | 0 (0%) | 0 (0%) |
Control | 0 (0%) | 6 (100%) | 10 (100%) |
male_sex | |||
Female | 26 (25%) | 4 (67%) | 7 (70%) |
Male | 78 (75%) | 2 (33%) | 3 (30%) |
race | |||
Asian | 3 (2.9%) | 0 (0%) | 0 (0%) |
Black | 3 (2.9%) | 1 (17%) | 1 (10%) |
Multiracial/More than one race | 1 (1.0%) | 0 (0%) | 0 (0%) |
Not available | 1 (1.0%) | 0 (0%) | 0 (0%) |
Other | 2 (1.9%) | 0 (0%) | 0 (0%) |
White | 94 (90%) | 5 (83%) | 9 (90%) |
ethnicity | |||
Hispanic/Latino | 1 (1.0%) | 0 (0%) | 0 (0%) |
Not Available | 3 (2.9%) | 6 (100%) | 0 (0%) |
Not Hispanic/Latino | 100 (96%) | 0 (0%) | 10 (100%) |
genetic_aortopathy | |||
Familial | 7 (7.5%) | 0 (0%) | 0 (0%) |
None | 63 (68%) | 6 (100%) | 8 (80%) |
Suspicious | 11 (12%) | 0 (0%) | 2 (20%) |
Syndromic | 12 (13%) | 0 (0%) | 0 (0%) |
No Data | 11 | 0 | 0 |
aortopathy_diagnosis | |||
Loeys-Dietz | 3 (3.4%) | 0 (0%) | 0 (0%) |
Marfan syndrome | 9 (10%) | 0 (0%) | 0 (0%) |
None | 63 (72%) | 6 (100%) | 8 (80%) |
Other | 13 (15%) | 0 (0%) | 2 (20%) |
No Data | 16 | 0 | 0 |
gene_identified | |||
ACTA2 | 2 (9.5%) | 0 (NA%) | 0 (0%) |
FBN1 | 8 (38%) | 0 (NA%) | 0 (0%) |
Other | 8 (38%) | 0 (NA%) | 2 (100%) |
SMAD3 | 1 (4.8%) | 0 (NA%) | 0 (0%) |
TGFBR1 | 1 (4.8%) | 0 (NA%) | 0 (0%) |
TGFBR2 | 1 (4.8%) | 0 (NA%) | 0 (0%) |
No Data | 83 | 6 | 8 |
aortic_valve | |||
Bicuspid | 58 (56%) | 0 (0%) | 0 (0%) |
Tricuspid | 45 (43%) | 3 (50%) | 10 (100%) |
Unknown | 1 (1.0%) | 0 (0%) | 0 (0%) |
Unknown/Indeterminate | 0 (0%) | 3 (50%) | 0 (0%) |
bav_type | |||
RL (Right-Left) Fusion | 36 (62%) | 0 (NA%) | 0 (NA%) |
RN (Right-Noncoronary) Fusion | 6 (10%) | 0 (NA%) | 0 (NA%) |
Sievers 0 | 7 (12%) | 0 (NA%) | 0 (NA%) |
Sievers II (Unicuspid) | 9 (16%) | 0 (NA%) | 0 (NA%) |
No Data | 46 | 6 | 10 |
ai | |||
Mild (+) | 20 (20%) | 1 (17%) | 0 (0%) |
Moderate (++) | 20 (20%) | 0 (0%) | 1 (10%) |
None/Trivial | 43 (42%) | 5 (83%) | 9 (90%) |
Severe (3+/4+) | 19 (19%) | 0 (0%) | 0 (0%) |
No Data | 2 | 0 | 0 |
aortic_stenosis | |||
Mild | 12 (12%) | 0 (0%) | 0 (0%) |
Moderate | 19 (19%) | 0 (0%) | 0 (0%) |
None | 68 (67%) | 6 (100%) | 10 (100%) |
Severe | 3 (2.9%) | 0 (0%) | 0 (0%) |
No Data | 2 | 0 | 0 |
hx_of_hypertension | 60 (58%) | 3 (50%) | 1 (10%) |
stroke | 4 (3.8%) | 3 (50%) | 2 (20%) |
diabetes | 5 (4.8%) | 0 (0%) | 1 (10%) |
copd | 2 (1.9%) | 1 (17%) | 1 (10%) |
dyslipidemia | 36 (35%) | 0 (0%) | 6 (60%) |
coronary_artery_disease | 21 (20%) | 0 (0%) | 4 (40%) |
No Data | 1 | 0 | 0 |
chronic_kidney_disease | 3 (2.9%) | 0 (0%) | 7 (70%) |
No Data | 1 | 0 | 0 |
congestive_heart_failure_previous_diagnosis | 3 (2.9%) | 0 (0%) | 9 (90%) |
No Data | 1 | 0 | 0 |
prior_cardiovascular_surgery | 6 (5.8%) | 0 (0%) | 2 (20%) |
No Data | 1 | 0 | 0 |
age_at_surgery | 56 (45, 64) | 56 (56, 58) | 59 (55, 64) |
height_cm | 180 (173, 185) | 166 (161, 169) | 169 (164, 174) |
No Data | 1 | 0 | 0 |
weight_kg | 89 (80, 105) | 81 (62, 91) | 71 (56, 81) |
No Data | 1 | 0 | 0 |
bmi_kg_m2 | 28.0 (25.3, 31.6) | 28.2 (23.5, 30.6) | 24.6 (22.0, 26.8) |
No Data | 1 | 0 | 0 |
max_root_diameter_cm_ct | 4.56 (4.17, 4.98) | NA (NA, NA) | 3.55 (3.38, 3.69) |
No Data | 1 | 6 | 0 |
max_mid_diameter_cm_ct | 4.69 (4.11, 5.02) | NA (NA, NA) | 3.16 (3.08, 3.41) |
No Data | 1 | 6 | 0 |
max_proximal_diameter_cm_ct | 4.56 (3.98, 5.12) | NA (NA, NA) | 3.13 (3.05, 3.35) |
No Data | 1 | 6 | 0 |
max_distal_diameter_cm_ct | 4.06 (3.56, 4.40) | NA (NA, NA) | 3.17 (2.96, 3.29) |
No Data | 3 | 6 | 1 |
max_diameter_cm_ct | 5.03 (4.74, 5.40) | NA (NA, NA) | 3.62 (3.42, 3.75) |
No Data | 1 | 6 | 0 |
1n (%); Median (IQR) | |||
Experimental Data
Characteristic | Aneurysm, N = 2411 | donor, N = 111 | recipient, N = 161 |
elbow_th | 0.29 (0.23, 0.36) | 0.25 (0.20, 0.33) | 0.24 (0.17, 0.29) |
ltm_th | 160 (122, 217) | 173 (159, 207) | 189 (132, 221) |
htm_th | 787 (569, 1,353) | 1,553 (1,054, 2,031) | 1,675 (1,436, 2,362) |
elbow_z | 0.30 (0.23, 0.37) | 0.20 (0.16, 0.25) | 0.16 (0.11, 0.18) |
ltm_z | 156 (131, 195) | 194 (160, 225) | 200 (181, 289) |
htm_z | 801 (497, 1,547) | 2,188 (1,537, 2,922) | 2,729 (1,890, 4,383) |
ratio | 1.03 (0.76, 1.33) | 0.77 (0.57, 1.08) | 0.78 (0.47, 0.97) |
region | |||
Dist | 59 (24%) | 1 (9.1%) | 0 (0%) |
Mid | 49 (20%) | 0 (0%) | 0 (0%) |
Prox | 66 (27%) | 4 (36%) | 7 (44%) |
Root | 67 (28%) | 6 (55%) | 9 (56%) |
1Median (IQR); n (%) | |||
Missing Data
| variable | n_miss | pct_miss |
|---|---|---|
| gene_identified | 222 | 82.8358209 |
| bav_type | 129 | 48.1343284 |
| aortopathy_diagnosis | 50 | 18.6567164 |
| genetic_aortopathy | 35 | 13.0597015 |
| max_distal_diameter_cm_ct | 17 | 6.3432836 |
| max_root_diameter_cm_ct | 13 | 4.8507463 |
| max_mid_diameter_cm_ct | 13 | 4.8507463 |
| max_proximal_diameter_cm_ct | 13 | 4.8507463 |
| max_diameter_cm_ct | 13 | 4.8507463 |
| ai | 7 | 2.6119403 |
| aortic_stenosis | 7 | 2.6119403 |
| height_cm | 4 | 1.4925373 |
| weight_kg | 4 | 1.4925373 |
| bmi_kg_m2 | 4 | 1.4925373 |
| coronary_artery_disease | 4 | 1.4925373 |
| prior_cardiovascular_surgery | 2 | 0.7462687 |
| chronic_kidney_disease | 1 | 0.3731343 |
| congestive_heart_failure_previous_diagnosis | 1 | 0.3731343 |
| …1 | 0 | 0.0000000 |
| record_id | 0 | 0.0000000 |
| project | 0 | 0.0000000 |
| region | 0 | 0.0000000 |
| elbow_th | 0 | 0.0000000 |
| elbow_z | 0 | 0.0000000 |
| ltm_th | 0 | 0.0000000 |
| ltm_z | 0 | 0.0000000 |
| htm_th | 0 | 0.0000000 |
| htm_z | 0 | 0.0000000 |
| tissue_type | 0 | 0.0000000 |
| disease | 0 | 0.0000000 |
| Root | 0 | 0.0000000 |
| Prox | 0 | 0.0000000 |
| Mid | 0 | 0.0000000 |
| Dist | 0 | 0.0000000 |
| age_at_surgery | 0 | 0.0000000 |
| male_sex | 0 | 0.0000000 |
| race | 0 | 0.0000000 |
| ethnicity | 0 | 0.0000000 |
| aortic_valve | 0 | 0.0000000 |
| hx_of_hypertension | 0 | 0.0000000 |
| stroke | 0 | 0.0000000 |
| diabetes | 0 | 0.0000000 |
| copd | 0 | 0.0000000 |
| dyslipidemia | 0 | 0.0000000 |
| ratio | 0 | 0.0000000 |
Examine each variable with high missingness
bav_type: missingness okay
All patients with BAV have bav_type
| aortic_valve | Total | ||||
|---|---|---|---|---|---|
| Bicuspid | Tricuspid | Unknown | Unknown/Indeterminate | ||
| bav_type | |||||
| RL (Right-Left) Fusion | 87 | 0 | 0 | 0 | 87 |
| RN (Right-Noncoronary) Fusion | 18 | 0 | 0 | 0 | 18 |
| Sievers 0 | 15 | 0 | 0 | 0 | 15 |
| Sievers II (Unicuspid) | 19 | 0 | 0 | 0 | 19 |
| NA | 0 | 121 | 3 | 5 | 129 |
| Total | 139 | 121 | 3 | 5 | 268 |
Genetic Aortopathy: Problem
3 Controls are listed as “suspicious” genetic history; several aneurysms ahve missing data
| genetic_aortopathy | Total | |||||
|---|---|---|---|---|---|---|
| Familial | None | Suspicious | Syndromic | NA | ||
| disease | ||||||
| Aneurysm | 23 | 142 | 22 | 19 | 35 | 241 |
| Control | 0 | 24 | 3 | 0 | 0 | 27 |
| Total | 23 | 166 | 25 | 19 | 35 | 268 |
Missing data is all among newer patients (MAT# > 200)
Aortopathy Diagnosis:: missingness okay
All patients with diagnosed CTD have data
| genetic_aortopathy |
| ||||
Familial | None | Suspicious | Syndromic | NA | Total | |
aortopathy_diagnosis | ||||||
Loeys-Dietz | 0 | 0 | 0 | 5 | 0 | 5 |
Marfan syndrome | 0 | 0 | 0 | 14 | 0 | 14 |
None | 0 | 166 | 0 | 0 | 0 | 166 |
Other | 12 | 0 | 21 | 0 | 0 | 33 |
NA | 11 | 0 | 4 | 0 | 35 | 50 |
Total | 23 | 166 | 25 | 19 | 35 | 268 |
Diameter
13 patients are missing all diameter measurements, and 4 are missing distal only
Both controls and aneurysms are missing data
| disease | variable | n_miss | pct_miss |
|---|---|---|---|
| Aneurysm | max_distal_diameter_cm_ct | 4 | 1.6597510 |
| Aneurysm | max_root_diameter_cm_ct | 2 | 0.8298755 |
| Aneurysm | max_mid_diameter_cm_ct | 2 | 0.8298755 |
| Aneurysm | max_proximal_diameter_cm_ct | 2 | 0.8298755 |
| Aneurysm | max_diameter_cm_ct | 2 | 0.8298755 |
| Control | max_distal_diameter_cm_ct | 13 | 48.1481481 |
| Control | max_root_diameter_cm_ct | 11 | 40.7407407 |
| Control | max_mid_diameter_cm_ct | 11 | 40.7407407 |
| Control | max_proximal_diameter_cm_ct | 11 | 40.7407407 |
| Control | max_diameter_cm_ct | 11 | 40.7407407 |