TBI_Two_brain_sample_analysis
LC/Qiu lab
2022-09-12
Initialize relevant libraries
Import libaries for analysis
# setwd("D:/BioinformaticsProjects/sc_exp4_TBI")
library(Seurat)
library(dplyr)
library(cowplot)
library(ggplot2)
library(rstatix)
library(SingleCellExperiment)
library(ComplexHeatmap)
library(RColorBrewer)
library(circlize)
library(patchwork)Import two samples; m10 = TBI, m11 = Sham
To minimize change of coding, keep the existing variable names as much as possile. Copy the slim_counts/ files to the m10 and m11 folder under ‘./slim_counts’
Quality Control
Quality assessment before filtering
Joint filtering effects:
Quality assessment after filtering
Selecting Data Subset
Filter data based on these criteria: nFeature_RNA < 7500& nFeature_RNA>75 & nCount_RNA > 1000 and then, added the filtering criteria of “percent.mt < 20” After subseting, only keeping those genes expressed in more than 20 cells
The dimension of pooled data is:19792, 40486
Reassess quality metrics
Quality metrics after filtered counts
Apply sctransform normalization
This steps can replace NormalizeData(),
ScaleData(), and FindVariableFeatures(). The
results of sctransform are stored in the “SCT” assay. It is assumed to
reveals sharper biological distinctions compared to the standard Seurat
workflow.
Since it is a normalization step, we have to do
separately for two different samples (that’s why split seurat objects
here), then only integrate the sample expression data in the next step,
integration analysis, to remove batch effect.
Integration of two samples
Select the most variable features to use for integration, we
will use 3000 features and IntegratData
Clustering
Run the standard workflow for linear and non-linear reduction, visualization and clustering
We use a resolution vector c(0.05, 0.5) for cluster identification, which seems appropriate for this sample size ~13K cells
Clustering quality control
This step gives us some idea about how is the distribution of the number of genes, number of UMIs, and percentage of mitochondrial genes in each cluster. Normally, we expect to see similar distribution of no. of genes (nFeature_RNA) and no. of UMIs (nCount_RNA).
As for the percent.mt (percentage of mitochondrial genes per cell), it can be a reference to check if those high intensity clusters might be having poor quality cells (if so, we can try to remove in the next step or adjust the metrics in the previous filtering step) or it might be due to the differences biologically.
Determine metrics to plot present in seurat_integrated@meta.data
NOTE from SQ: for certain feature if not found in ‘integrated’ assay (may only have 2000 high variable features), you need to switch to “RNA” or “SCT” assay using DefaultAssay(seurat_integrated) <- “RNA”
Find all markers in two samples for cell type identification
Write all gene markers to a .csv file on local drive
Plotting top markers for each cluster
setting up plotting parameters
##Violin plot for selected gene markers For example, genes in the MAPK
pathway
Define genes of interest and do heatmaps
Find markers for specific cluster in two samples for cell type identification
Identifying cell type
Option 1: SingleR package with built-in reference
I use a collection of mouse bulk RNA-seq data sets obtained from celldex package (Benayoun et al. 2019). A variety of cell types are available, mostly from blood but also covering several other tissues. This identifies marker genes from the reference and uses them to compute assignment scores (based on the Spearman correlation across markers) for each cell in the test dataset against each label in the reference. The label with the highest score is the assigned to the test cell, possibly with further fine-tuning to resolve closely related labels.
This reference consists of a collection of mouse bulk RNA-seq data sets downloaded from the gene expression omnibus Benayoun et al. 2019. A variety of cell types are available, again mostly from blood but also covering several other tissues.
Option 2: manual annotation
####Plotting Astrocyte Markers
####Plotting Microglia Markers
####Plotting Endothelial Markers
####Plotting Oligodendrocyte Markers
####Plotting Glutamatergic Neuron Markers
####Plotting Gabaergic Neuron Markers
####Plotting Oligodendrocyte Precursor Markers
Rename cluster based on the SingleR results and manual annotation
Option 3: manual annotation
Refer to Tasic et al, Nature 2018, [marker list] https://github.com/AllenInstitute/tasic2018analysis/blob/master/RNA-seq%20Analysis/markers.R
## Differential expression Analysis for groups Now we do a DEG
analysis for all genes between the two groups
## [[1]]
## p_val avg_log2FC pct.1 pct.2 p_val_adj comparison
## Hbb-bs 0.000000e+00 -1.1820492 0.367 0.024 0.000000e+00 CTL_MUT
## Hba-a1 0.000000e+00 -2.7592429 0.287 0.006 0.000000e+00 CTL_MUT
## Slc38a3 0.000000e+00 12.1817844 0.151 0.031 0.000000e+00 CTL_MUT
## Wnt7a 0.000000e+00 4.4429502 0.257 0.015 0.000000e+00 CTL_MUT
## Plk4 0.000000e+00 2.3941872 0.297 0.010 0.000000e+00 CTL_MUT
## Malt1 5.018873e-308 1.3402763 0.178 0.050 1.505662e-304 CTL_MUT
## Slc25a18 5.231958e-307 4.9996135 0.158 0.065 1.569587e-303 CTL_MUT
## G530011O06Rik 2.099695e-306 3.2651878 0.149 0.019 6.299085e-303 CTL_MUT
## Rarb 1.697387e-303 -3.2907242 0.225 0.031 5.092161e-300 CTL_MUT
## Gm15726 1.116634e-292 -2.8468354 0.203 0.019 3.349903e-289 CTL_MUT
## Gad1 3.393792e-274 1.1868789 0.159 0.094 1.018138e-270 CTL_MUT
## Ctsz 3.060818e-270 0.6997049 0.146 0.135 9.182453e-267 CTL_MUT
## Sox9 1.005965e-267 -6.4304077 0.140 0.039 3.017894e-264 CTL_MUT
## Tac1 3.738461e-267 -1.4471742 0.176 0.022 1.121538e-263 CTL_MUT
## Tek 6.354779e-266 2.8863885 0.129 0.051 1.906434e-262 CTL_MUT
## Gm48619 3.565909e-263 -2.8425817 0.291 0.008 1.069773e-259 CTL_MUT
## Lamb2 1.527507e-255 -10.5296965 0.146 0.029 4.582520e-252 CTL_MUT
## Nfkbiz 2.936591e-249 1.1596464 0.122 0.088 8.809774e-246 CTL_MUT
## Egr4 5.723795e-249 -11.4013766 0.174 0.086 1.717139e-245 CTL_MUT
## Rbp1 7.606545e-249 -2.7194721 0.195 0.035 2.281963e-245 CTL_MUT
## Gm10561 5.933040e-232 1.6909159 0.166 0.014 1.779912e-228 CTL_MUT
## Gpx8 1.828980e-221 -1.9606315 0.184 0.013 5.486940e-218 CTL_MUT
## Pcdh8 1.401905e-214 -3.4393420 0.179 0.071 4.205715e-211 CTL_MUT
## Syt2 3.242327e-211 0.3074194 0.150 0.044 9.726982e-208 CTL_MUT
## Capn3 6.666113e-211 -0.9941983 0.193 0.030 1.999834e-207 CTL_MUT
## Vwa1 1.885623e-207 -7.2766695 0.124 0.052 5.656869e-204 CTL_MUT
## Ppp1r15a 6.143382e-199 10.2704161 0.171 0.058 1.843015e-195 CTL_MUT
## Atoh8 1.370093e-198 -0.9671494 0.202 0.008 4.110278e-195 CTL_MUT
## Hba-a2 2.669978e-196 -1.0375873 0.253 0.007 8.009933e-193 CTL_MUT
## Acsf2 1.359338e-195 -1.8788673 0.234 0.011 4.078013e-192 CTL_MUT
## Nat8 1.429111e-195 -0.7756860 0.181 0.008 4.287332e-192 CTL_MUT
## Slc30a10 5.785835e-195 -1.8654781 0.186 0.038 1.735750e-191 CTL_MUT
## Fbxo30 6.461366e-194 -9.0847937 0.199 0.026 1.938410e-190 CTL_MUT
## Arhgef40 4.092113e-193 5.0744127 0.218 0.022 1.227634e-189 CTL_MUT
## Pdlim4 1.699597e-191 -1.4811561 0.158 0.037 5.098790e-188 CTL_MUT
## Arhgap6 5.816201e-191 -0.8929816 0.155 0.026 1.744860e-187 CTL_MUT
## Rbm20 6.381121e-191 8.8244698 0.198 0.025 1.914336e-187 CTL_MUT
## Ttpa 9.019319e-189 -1.8458374 0.220 0.007 2.705796e-185 CTL_MUT
## Prdm16os 3.603234e-185 3.1707640 0.200 0.016 1.080970e-181 CTL_MUT
## Alpk1 4.052330e-182 -2.4321457 0.174 0.044 1.215699e-178 CTL_MUT
## Slc14a1 1.872906e-176 -1.1468034 0.165 0.013 5.618719e-173 CTL_MUT
## Coq10b 1.843493e-175 1.0500619 0.190 0.145 5.530478e-172 CTL_MUT
## 4930587E11Rik 1.343814e-174 -1.0460168 0.174 0.064 4.031443e-171 CTL_MUT
## Fhad1 4.755187e-174 -7.7813951 0.207 0.040 1.426556e-170 CTL_MUT
## Frmpd1 9.378132e-172 -1.7298780 0.135 0.049 2.813440e-168 CTL_MUT
## Gm16351 4.671389e-171 1.2321940 0.191 0.064 1.401417e-167 CTL_MUT
## Cdo1 2.256811e-169 0.6967524 0.178 0.029 6.770434e-166 CTL_MUT
## Hapln1 1.023458e-167 3.3695517 0.160 0.025 3.070373e-164 CTL_MUT
## Gbe1 1.562741e-164 -11.4120311 0.206 0.042 4.688223e-161 CTL_MUT
## Gpc4 1.756304e-164 1.4710906 0.185 0.076 5.268911e-161 CTL_MUT
## Kcnc2 3.541639e-164 -0.7782917 0.206 0.174 1.062492e-160 CTL_MUT
## B230216N24Rik 8.054543e-163 0.6071440 0.155 0.071 2.416363e-159 CTL_MUT
## Igfbp2 1.270330e-157 -2.2763695 0.142 0.031 3.810991e-154 CTL_MUT
## Ppp1r3g 4.253317e-156 -2.8573777 0.153 0.023 1.275995e-152 CTL_MUT
## Selenbp1 8.617491e-156 1.2991798 0.226 0.010 2.585247e-152 CTL_MUT
## Zc3h12c 4.880041e-153 -12.8070461 0.191 0.063 1.464012e-149 CTL_MUT
## Adamts1 7.138336e-153 5.8810353 0.160 0.059 2.141501e-149 CTL_MUT
## Tlr3 7.186982e-152 -5.6907012 0.140 0.034 2.156095e-148 CTL_MUT
## Oaf 1.208798e-151 -0.9313548 0.144 0.022 3.626395e-148 CTL_MUT
## P2rx7 3.644816e-151 1.0461044 0.205 0.028 1.093445e-147 CTL_MUT
## Sdsl 1.217045e-150 -7.0350529 0.203 0.012 3.651134e-147 CTL_MUT
## H2-K1 7.969715e-150 -1.0947773 0.172 0.067 2.390915e-146 CTL_MUT
## Mid1 2.296731e-149 4.6493343 0.172 0.141 6.890192e-146 CTL_MUT
## Lhfpl2 3.272380e-149 3.4876185 0.201 0.056 9.817139e-146 CTL_MUT
## Gm48342 1.267440e-148 3.9368567 0.241 0.008 3.802321e-145 CTL_MUT
## Otulinl 1.309453e-148 -5.3148529 0.148 0.050 3.928358e-145 CTL_MUT
## Smim1 2.549587e-147 -1.1375939 0.147 0.088 7.648762e-144 CTL_MUT
## Lnx2 3.082893e-147 -0.9845643 0.150 0.029 9.248680e-144 CTL_MUT
## Nr4a3 5.552551e-145 -2.6956681 0.178 0.111 1.665765e-141 CTL_MUT
## Gm16168 1.390574e-144 -1.7393806 0.138 0.108 4.171723e-141 CTL_MUT
## Fam102b 4.399092e-144 -2.9496465 0.150 0.073 1.319727e-140 CTL_MUT
## Sox1ot 7.713157e-144 -0.8765255 0.147 0.018 2.313947e-140 CTL_MUT
## AW011738 2.626185e-143 0.9201679 0.163 0.021 7.878555e-140 CTL_MUT
## Plod1 3.213484e-142 2.1043168 0.119 0.070 9.640453e-139 CTL_MUT
## Rcn3 9.800792e-141 -3.1602448 0.108 0.011 2.940238e-137 CTL_MUT
## Mylk 6.262299e-140 -0.7061356 0.144 0.024 1.878690e-136 CTL_MUT
## Cemip2 1.410526e-139 -3.8036214 0.182 0.057 4.231578e-136 CTL_MUT
## Alox5ap 3.351873e-139 -1.0376835 0.198 0.014 1.005562e-135 CTL_MUT
## Slit2 3.691466e-139 5.3188403 0.178 0.110 1.107440e-135 CTL_MUT
## Pnoc 2.196027e-138 1.1570529 0.157 0.015 6.588080e-135 CTL_MUT
## Gm20319 3.670611e-138 -2.7012283 0.200 0.025 1.101183e-134 CTL_MUT
## Tnnt1 4.707914e-138 -2.0511122 0.186 0.004 1.412374e-134 CTL_MUT
## Sugct 1.376283e-137 6.8604020 0.172 0.023 4.128850e-134 CTL_MUT
## Myl12a 2.133765e-136 4.1417200 0.159 0.045 6.401295e-133 CTL_MUT
## Hsd11b1 3.540144e-136 2.9723378 0.136 0.047 1.062043e-132 CTL_MUT
## Gm13889 5.862253e-135 0.5027681 0.179 0.104 1.758676e-131 CTL_MUT
## Gm42439 1.335783e-134 3.7727722 0.268 0.194 4.007349e-131 CTL_MUT
## Spink8 3.220532e-134 -10.9942370 0.182 0.093 9.661596e-131 CTL_MUT
## Zmynd12 1.416218e-131 -3.9670040 0.289 0.004 4.248654e-128 CTL_MUT
## Map3k20 4.307707e-131 0.3948760 0.142 0.036 1.292312e-127 CTL_MUT
## Mdk 1.611592e-130 0.7881113 0.161 0.041 4.834776e-127 CTL_MUT
## Gsg1l 4.498207e-130 7.4479460 0.190 0.097 1.349462e-126 CTL_MUT
## G0s2 5.364891e-129 -3.8909061 0.138 0.022 1.609467e-125 CTL_MUT
## Pbx3 5.865994e-129 -0.5693833 0.186 0.034 1.759798e-125 CTL_MUT
## 8030451A03Rik 7.594542e-129 -0.9555523 0.173 0.005 2.278363e-125 CTL_MUT
## Tst 5.554036e-128 10.2192534 0.147 0.110 1.666211e-124 CTL_MUT
## Ifit3 5.580327e-126 2.0742202 0.205 0.009 1.674098e-122 CTL_MUT
## Fbxo33 1.389055e-124 -7.7521394 0.161 0.134 4.167165e-121 CTL_MUT
## Ccdc152 2.640639e-124 -3.9092407 0.105 0.002 7.921917e-121 CTL_MUT
## Entpd2 2.801662e-124 -3.7027550 0.173 0.010 8.404987e-121 CTL_MUT
## Ermn 6.223033e-124 2.7731036 0.106 0.126 1.866910e-120 CTL_MUT
## Car2 8.402773e-124 3.6345177 0.164 0.184 2.520832e-120 CTL_MUT
## Tmem47 1.756244e-123 1.5560180 0.153 0.109 5.268731e-120 CTL_MUT
## Pon2 5.770268e-123 5.2999648 0.158 0.081 1.731080e-119 CTL_MUT
## Cntfr 1.219226e-121 -8.5839804 0.159 0.106 3.657679e-118 CTL_MUT
## Gm19935 3.294694e-121 2.8785703 0.143 0.004 9.884083e-118 CTL_MUT
## 1700047M11Rik 9.981738e-121 -1.3735103 0.100 0.091 2.994521e-117 CTL_MUT
## Dnah7b 4.447620e-120 3.3387552 0.194 0.014 1.334286e-116 CTL_MUT
## Nwd1 6.610127e-120 3.0026873 0.120 0.077 1.983038e-116 CTL_MUT
## Slc15a2 1.248410e-119 -0.7867219 0.140 0.076 3.745231e-116 CTL_MUT
## 2900052N01Rik 5.148478e-119 5.0178799 0.163 0.046 1.544544e-115 CTL_MUT
## Zeb2os 1.080629e-118 -0.5224255 0.190 0.021 3.241887e-115 CTL_MUT
## Fzd2 1.368063e-118 2.9225159 0.133 0.016 4.104190e-115 CTL_MUT
## Hspa1b 2.237844e-118 3.4364829 0.154 0.024 6.713533e-115 CTL_MUT
## Acss3 3.369235e-118 -0.6732841 0.182 0.004 1.010771e-114 CTL_MUT
## Angpt1 4.000747e-117 2.8042883 0.165 0.025 1.200224e-113 CTL_MUT
## Cacna2d2 9.297605e-117 -2.5698833 0.117 0.050 2.789282e-113 CTL_MUT
## Fhit 3.450631e-116 -1.6578302 0.210 0.147 1.035189e-112 CTL_MUT
## Cemip 8.518012e-116 -3.2340018 0.178 0.086 2.555404e-112 CTL_MUT
## C77080 3.328189e-115 -1.2531478 0.158 0.018 9.984567e-112 CTL_MUT
## Btbd17 6.075161e-114 5.3468765 0.128 0.082 1.822548e-110 CTL_MUT
## Ccp110 1.420081e-113 5.2713068 0.138 0.102 4.260242e-110 CTL_MUT
## Bricd5 1.848422e-113 -3.7015912 0.112 0.005 5.545265e-110 CTL_MUT
## Bmpr1b 3.272751e-113 -1.9464798 0.119 0.075 9.818253e-110 CTL_MUT
## Slc16a6 6.457563e-113 -1.5892934 0.148 0.041 1.937269e-109 CTL_MUT
## H2-D1 9.094398e-113 -0.4152484 0.154 0.032 2.728319e-109 CTL_MUT
## 0610040J01Rik 1.000302e-111 9.9712837 0.183 0.031 3.000907e-108 CTL_MUT
## Slc16a1 1.813379e-111 -12.9011634 0.150 0.066 5.440138e-108 CTL_MUT
## Ednrb 3.003727e-111 5.6278709 0.123 0.076 9.011180e-108 CTL_MUT
## Lpar6 1.496132e-110 2.2260614 0.194 0.014 4.488397e-107 CTL_MUT
## Rgcc 1.277784e-109 -0.8269162 0.122 0.086 3.833352e-106 CTL_MUT
## Slc25a21 1.717960e-109 -1.0888999 0.133 0.008 5.153880e-106 CTL_MUT
## Slc7a8 1.865457e-109 -5.3020366 0.226 0.137 5.596371e-106 CTL_MUT
## Lypd6 5.071358e-109 8.2105216 0.170 0.057 1.521407e-105 CTL_MUT
## Adhfe1 3.163838e-107 -5.9384460 0.139 0.023 9.491513e-104 CTL_MUT
## Edem1 1.487759e-106 -12.2089017 0.173 0.034 4.463276e-103 CTL_MUT
## Bcl2l11 3.581223e-106 -3.9779743 0.153 0.028 1.074367e-102 CTL_MUT
## Nrarp 4.315582e-106 -9.1993844 0.207 0.011 1.294675e-102 CTL_MUT
## Gamt 1.449112e-105 -2.8680559 0.113 0.118 4.347335e-102 CTL_MUT
## Gm21798 4.379566e-105 1.3342873 0.168 0.056 1.313870e-101 CTL_MUT
## H2-Q4 1.298145e-104 -0.3789511 0.171 0.008 3.894435e-101 CTL_MUT
## Ttc23 1.772753e-103 -4.8865924 0.174 0.049 5.318259e-100 CTL_MUT
## Crygn 1.949543e-103 -1.5827802 0.103 0.002 5.848628e-100 CTL_MUT
## Vcam1 4.743071e-103 -9.7611114 0.177 0.028 1.422921e-99 CTL_MUT
## Sowahc 8.034779e-103 -2.8031496 0.200 0.022 2.410434e-99 CTL_MUT
## Chrdl1 1.154495e-102 1.5053441 0.171 0.013 3.463484e-99 CTL_MUT
## Plppr1 2.039852e-102 2.0086725 0.196 0.087 6.119555e-99 CTL_MUT
## Agt 3.804308e-102 -1.5165193 0.147 0.021 1.141292e-98 CTL_MUT
## Ugt8a 4.311575e-102 -4.3057358 0.120 0.149 1.293473e-98 CTL_MUT
## Gpnmb 5.237191e-102 -2.8307976 0.204 0.011 1.571157e-98 CTL_MUT
## Sall3 1.041454e-101 -1.7250994 0.101 0.016 3.124363e-98 CTL_MUT
## Rapgef3 1.400291e-101 -0.5141041 0.132 0.067 4.200872e-98 CTL_MUT
## Maff 1.946479e-101 -1.2165832 0.180 0.012 5.839437e-98 CTL_MUT
## Slc48a1 1.313813e-99 -1.0795939 0.183 0.205 3.941438e-96 CTL_MUT
## A830019P07Rik 2.499856e-98 -1.1946514 0.187 0.011 7.499569e-95 CTL_MUT
## Cpne7 2.587525e-98 -10.2335330 0.116 0.051 7.762575e-95 CTL_MUT
## B2m 8.147930e-98 -1.3033025 0.154 0.075 2.444379e-94 CTL_MUT
## Dner 8.978561e-98 -13.4979827 0.194 0.182 2.693568e-94 CTL_MUT
## Atp1b2 2.109221e-97 1.5000747 0.180 0.182 6.327662e-94 CTL_MUT
## Apoc1 4.070762e-97 -1.1428700 0.152 0.003 1.221229e-93 CTL_MUT
## Tpm4 4.868084e-96 3.2392498 0.144 0.065 1.460425e-92 CTL_MUT
## Lacc1 2.883182e-95 0.9430476 0.159 0.019 8.649546e-92 CTL_MUT
## Col25a1 6.208157e-95 -0.7985613 0.181 0.088 1.862447e-91 CTL_MUT
## Kctd8 2.917589e-94 0.9795673 0.143 0.045 8.752768e-91 CTL_MUT
## Grin2c 3.435091e-94 -4.0701126 0.110 0.058 1.030527e-90 CTL_MUT
## Pdyn 8.177882e-94 -1.3544339 0.173 0.023 2.453365e-90 CTL_MUT
## Smpdl3a 1.442572e-93 -0.7960029 0.144 0.081 4.327717e-90 CTL_MUT
## Aspa 1.567302e-93 -2.5565290 0.096 0.108 4.701906e-90 CTL_MUT
## Ndp 2.240315e-93 -0.5072711 0.203 0.007 6.720944e-90 CTL_MUT
## Ccdc190 2.946074e-93 -0.4349398 0.140 0.017 8.838222e-90 CTL_MUT
## Gm49127 3.960101e-93 -1.8508024 0.174 0.018 1.188030e-89 CTL_MUT
## Aldh1l1 4.520769e-93 7.4418881 0.144 0.063 1.356231e-89 CTL_MUT
## Filip1 6.587921e-93 -1.0370727 0.152 0.076 1.976376e-89 CTL_MUT
## Aldh1a1 7.842256e-93 -1.3083921 0.138 0.072 2.352677e-89 CTL_MUT
## C030018K13Rik 8.125635e-93 -1.4872834 0.130 0.012 2.437690e-89 CTL_MUT
## Fam20a 8.551102e-93 -3.0288697 0.105 0.084 2.565330e-89 CTL_MUT
## Mlph 2.095639e-92 -0.7196063 0.106 0.005 6.286917e-89 CTL_MUT
## Ppp1r3c 1.205695e-91 -3.4557328 0.135 0.048 3.617084e-88 CTL_MUT
## Chst7 4.524186e-91 -0.3490163 0.145 0.008 1.357256e-87 CTL_MUT
## Sept4 1.332616e-90 2.3717257 0.177 0.210 3.997847e-87 CTL_MUT
## Gm28376 3.517499e-90 -11.1773288 0.287 0.266 1.055250e-86 CTL_MUT
## Arl4c 5.456062e-90 5.3397740 0.140 0.063 1.636819e-86 CTL_MUT
## Airn 6.037502e-90 -12.0761864 0.160 0.070 1.811250e-86 CTL_MUT
## Serhl 7.270044e-90 2.9519219 0.184 0.013 2.181013e-86 CTL_MUT
## Cbs 8.312729e-90 5.1703511 0.126 0.044 2.493819e-86 CTL_MUT
## S100a11 1.973525e-89 -4.2350730 0.137 0.012 5.920574e-86 CTL_MUT
## P2ry14 2.036046e-89 -1.4472054 0.220 0.169 6.108137e-86 CTL_MUT
## Cpt1a 2.254711e-89 -6.0263249 0.195 0.041 6.764132e-86 CTL_MUT
## 4930567K20Rik 2.472972e-89 -11.1350141 0.182 0.041 7.418917e-86 CTL_MUT
## Hspa1a 6.433488e-89 1.0807423 0.126 0.047 1.930046e-85 CTL_MUT
## Pnpla7 9.110708e-89 4.4423558 0.121 0.064 2.733213e-85 CTL_MUT
## Mapk4 3.465218e-88 -3.0606588 0.256 0.236 1.039565e-84 CTL_MUT
## Tcirg1 4.272272e-88 -9.9140007 0.150 0.026 1.281682e-84 CTL_MUT
## Il4i1 1.209629e-87 -1.4313958 0.199 0.007 3.628886e-84 CTL_MUT
## Nusap1 3.490759e-87 -1.1277270 0.269 0.023 1.047228e-83 CTL_MUT
## Ezr 4.230975e-87 -0.4756579 0.149 0.061 1.269293e-83 CTL_MUT
## Myo3b 4.224991e-86 -5.1361741 0.180 0.009 1.267497e-82 CTL_MUT
## Sv2c 4.236984e-86 -0.4263033 0.113 0.072 1.271095e-82 CTL_MUT
## Klf6 7.885931e-86 -2.1189720 0.145 0.096 2.365779e-82 CTL_MUT
## Ghr 8.678259e-86 -4.2919566 0.206 0.092 2.603478e-82 CTL_MUT
## Fam181b 2.011183e-85 9.3574799 0.211 0.023 6.033548e-82 CTL_MUT
## Gm16272 3.325815e-85 -1.0256190 0.252 0.007 9.977446e-82 CTL_MUT
## Ier3 3.824324e-85 -2.4785344 0.114 0.063 1.147297e-81 CTL_MUT
## Herpud1 6.153981e-85 5.8517585 0.198 0.133 1.846194e-81 CTL_MUT
## Lgi3 8.449023e-85 2.1638549 0.177 0.176 2.534707e-81 CTL_MUT
## Heg1 1.522115e-84 -3.7115115 0.149 0.078 4.566346e-81 CTL_MUT
## Gm1992 2.019219e-84 6.8166929 0.188 0.092 6.057656e-81 CTL_MUT
## Arhgef10 2.600092e-84 6.3029133 0.103 0.081 7.800276e-81 CTL_MUT
## Hes5 2.621625e-84 -1.8741368 0.151 0.036 7.864874e-81 CTL_MUT
## Txndc11 2.740338e-84 -1.0930254 0.193 0.140 8.221013e-81 CTL_MUT
## Kdm6b 3.442237e-84 -5.6615670 0.169 0.071 1.032671e-80 CTL_MUT
## Id3 1.507584e-83 -1.5205490 0.112 0.072 4.522753e-80 CTL_MUT
## Gm13684 4.944121e-83 -5.3389333 0.170 0.029 1.483236e-79 CTL_MUT
## Tubb4a 5.986851e-83 0.9456979 0.224 0.238 1.796055e-79 CTL_MUT
## Tiparp 6.408619e-83 0.5431870 0.168 0.117 1.922586e-79 CTL_MUT
## Tcn2 7.795643e-83 -0.5131634 0.172 0.044 2.338693e-79 CTL_MUT
## Slc7a10 1.544803e-82 -1.1930866 0.100 0.063 4.634410e-79 CTL_MUT
## Mmp15 1.646903e-82 0.7108499 0.168 0.019 4.940708e-79 CTL_MUT
## Cryab 2.315871e-82 -0.6764396 0.164 0.191 6.947614e-79 CTL_MUT
## Trf 3.895145e-82 1.9464146 0.142 0.168 1.168544e-78 CTL_MUT
## Pigk 1.662833e-81 -0.7574705 0.314 0.283 4.988498e-78 CTL_MUT
## Pax6 5.115771e-81 3.3290416 0.122 0.032 1.534731e-77 CTL_MUT
## Ptgs1 6.768556e-81 1.7928162 0.124 0.024 2.030567e-77 CTL_MUT
## 1700034P13Rik 2.158614e-80 -4.9697203 0.247 0.010 6.475842e-77 CTL_MUT
## Sox10 8.106173e-80 7.5052604 0.103 0.107 2.431852e-76 CTL_MUT
## Angptl4 9.874195e-80 -0.5777404 0.168 0.006 2.962258e-76 CTL_MUT
## Sirpa 1.118276e-79 -2.8091865 0.236 0.223 3.354827e-76 CTL_MUT
## Id4 2.467019e-79 -7.1519982 0.142 0.056 7.401056e-76 CTL_MUT
## Lair1 9.430909e-79 -4.3391475 0.144 0.018 2.829273e-75 CTL_MUT
## Raver2 3.624792e-78 3.0919466 0.208 0.093 1.087438e-74 CTL_MUT
## Pvalb 7.108519e-78 -1.0513459 0.180 0.075 2.132556e-74 CTL_MUT
## Pdpn 1.665729e-77 2.5846933 0.147 0.019 4.997186e-74 CTL_MUT
## Cntnap5b 2.047216e-77 -5.2741204 0.232 0.181 6.141648e-74 CTL_MUT
## Inhba 2.639881e-77 -2.5886433 0.204 0.060 7.919643e-74 CTL_MUT
## Gng11 3.886091e-77 4.3065865 0.124 0.128 1.165827e-73 CTL_MUT
## Gm47123 9.829898e-77 -0.7154535 0.111 0.002 2.948970e-73 CTL_MUT
## Slc7a11 1.131662e-76 -0.7646382 0.110 0.045 3.394987e-73 CTL_MUT
## Gm39323 1.275100e-76 0.4900422 0.129 0.003 3.825299e-73 CTL_MUT
## Frem2 1.363126e-76 0.3953808 0.109 0.014 4.089377e-73 CTL_MUT
## Fkbp10 1.983389e-76 -3.3466962 0.132 0.005 5.950166e-73 CTL_MUT
## 4930589L23Rik 4.346923e-76 -0.9764810 0.100 0.002 1.304077e-72 CTL_MUT
## Vasp 6.238033e-76 5.4891801 0.170 0.018 1.871410e-72 CTL_MUT
## Myoc 1.443694e-75 2.8687788 0.190 0.150 4.331083e-72 CTL_MUT
## Pros1 2.036324e-75 -0.7465940 0.164 0.033 6.108972e-72 CTL_MUT
## Epha10 4.893093e-75 5.7912169 0.240 0.160 1.467928e-71 CTL_MUT
## Trim30d 1.133144e-74 -1.1929375 0.102 0.005 3.399432e-71 CTL_MUT
## Fcgrt 2.159908e-74 -0.3721817 0.111 0.047 6.479724e-71 CTL_MUT
## Prr5l 5.058740e-74 -0.9101972 0.111 0.128 1.517622e-70 CTL_MUT
## Nhs 5.559255e-74 -3.6167422 0.144 0.034 1.667777e-70 CTL_MUT
## Myorg 9.008167e-74 -3.3123295 0.116 0.022 2.702450e-70 CTL_MUT
## Rras2 1.017531e-73 3.6023805 0.207 0.153 3.052593e-70 CTL_MUT
## Crybg3 3.428294e-73 5.8600216 0.145 0.043 1.028488e-69 CTL_MUT
## P2ry12 5.310846e-73 -4.2974797 0.173 0.093 1.593254e-69 CTL_MUT
## Lyrm4 1.801007e-72 -2.7463356 0.142 0.060 5.403021e-69 CTL_MUT
## Ltbp1 1.832770e-72 4.3681055 0.153 0.040 5.498311e-69 CTL_MUT
## Rnf213 2.233440e-72 -5.4072767 0.172 0.022 6.700320e-69 CTL_MUT
## Onecut1 2.982441e-72 -6.7211359 0.130 0.007 8.947324e-69 CTL_MUT
## Nacc2 3.662735e-72 1.8205506 0.146 0.095 1.098820e-68 CTL_MUT
## Fam107b 3.928929e-72 -5.2923309 0.196 0.052 1.178679e-68 CTL_MUT
## Rnf180 3.965225e-72 -4.6240445 0.173 0.079 1.189567e-68 CTL_MUT
## Adamts12 5.222583e-72 0.2874213 0.100 0.003 1.566775e-68 CTL_MUT
## Lpar4 7.284229e-72 -7.7960185 0.210 0.008 2.185269e-68 CTL_MUT
## Trim25 1.414051e-71 -1.4303811 0.119 0.012 4.242153e-68 CTL_MUT
## Gsn 1.570167e-71 1.0114922 0.109 0.109 4.710501e-68 CTL_MUT
## Gm44710 3.180851e-71 0.7056561 0.102 0.004 9.542554e-68 CTL_MUT
## Gm10563 5.568438e-71 -2.6018425 0.194 0.050 1.670531e-67 CTL_MUT
## Sdc4 5.581913e-71 -8.2395063 0.135 0.072 1.674574e-67 CTL_MUT
## Paqr6 7.164738e-71 -2.6643429 0.142 0.014 2.149421e-67 CTL_MUT
## Junb 8.386802e-71 0.7263766 0.178 0.192 2.516041e-67 CTL_MUT
## Slc7a1 9.442648e-71 -6.3748626 0.153 0.102 2.832795e-67 CTL_MUT
## Tfcp2l1 1.447135e-70 -0.9308674 0.155 0.007 4.341406e-67 CTL_MUT
## Mmrn2 2.600473e-70 -1.7807778 0.142 0.013 7.801418e-67 CTL_MUT
## Hist1h2ae 5.866889e-70 1.0017282 0.218 0.016 1.760067e-66 CTL_MUT
## E130114P18Rik 9.378950e-70 -3.6461182 0.163 0.031 2.813685e-66 CTL_MUT
## D930020B18Rik 1.027267e-69 -0.9367642 0.142 0.002 3.081800e-66 CTL_MUT
## Ascl1 1.265164e-69 0.5182966 0.217 0.020 3.795493e-66 CTL_MUT
## Plcd4 3.344081e-69 1.2066890 0.126 0.039 1.003224e-65 CTL_MUT
## Sorcs2 5.542789e-69 3.7048587 0.209 0.128 1.662837e-65 CTL_MUT
## Hepacam 1.135670e-68 -2.2994136 0.149 0.156 3.407009e-65 CTL_MUT
## Cnn3 1.396960e-68 0.4452473 0.195 0.091 4.190880e-65 CTL_MUT
## Gm29508 1.531892e-68 -0.6251959 0.221 0.004 4.595675e-65 CTL_MUT
## Thap8 2.379942e-68 -1.1615052 0.112 0.003 7.139826e-65 CTL_MUT
## Gdpd2 2.472097e-68 -0.5105990 0.124 0.007 7.416290e-65 CTL_MUT
## Lgals3 2.891291e-68 -1.1920966 0.130 0.002 8.673872e-65 CTL_MUT
## Dhrs3 3.162333e-68 3.9760096 0.169 0.039 9.486999e-65 CTL_MUT
## Baiap2l1 5.998630e-68 -1.6121635 0.153 0.007 1.799589e-64 CTL_MUT
## Klhdc7a 6.027144e-68 -1.6815725 0.136 0.011 1.808143e-64 CTL_MUT
## Hopx 1.625305e-67 -4.3531657 0.143 0.035 4.875914e-64 CTL_MUT
## Qdpr 2.127024e-67 -2.5220569 0.190 0.226 6.381072e-64 CTL_MUT
## Eya4 3.591567e-67 -1.3784754 0.135 0.030 1.077470e-63 CTL_MUT
## Epha3 6.850467e-67 -3.8639286 0.193 0.100 2.055140e-63 CTL_MUT
## Pde8a 9.645287e-67 7.8513844 0.121 0.100 2.893586e-63 CTL_MUT
## Lgi4 2.408390e-66 4.8834280 0.113 0.043 7.225169e-63 CTL_MUT
## Fgfr3 2.580817e-66 -0.6347884 0.110 0.067 7.742450e-63 CTL_MUT
## Rassf2 2.626844e-66 2.7268494 0.128 0.044 7.880531e-63 CTL_MUT
## Vgf 3.056104e-66 -9.1981378 0.211 0.165 9.168311e-63 CTL_MUT
## Tnc 3.709378e-66 -0.6318353 0.110 0.019 1.112813e-62 CTL_MUT
## Scara3 6.157652e-66 -3.7789503 0.103 0.044 1.847296e-62 CTL_MUT
## Lgals1 1.080425e-65 -8.1254475 0.157 0.043 3.241275e-62 CTL_MUT
## Gm14569 1.443898e-65 -0.9308476 0.108 0.010 4.331695e-62 CTL_MUT
## Mpp7 1.532878e-65 -2.8557489 0.203 0.071 4.598633e-62 CTL_MUT
## Amotl1 1.832298e-65 -5.9655812 0.154 0.038 5.496893e-62 CTL_MUT
## P3h2 1.975879e-65 -2.6625274 0.174 0.039 5.927638e-62 CTL_MUT
## Psd2 2.848512e-65 5.4452126 0.130 0.033 8.545536e-62 CTL_MUT
## Dnah3 8.456488e-65 -4.7119812 0.174 0.004 2.536946e-61 CTL_MUT
## Mgst1 1.018343e-64 2.4200421 0.127 0.012 3.055030e-61 CTL_MUT
## Rbp4 1.165751e-64 0.5045945 0.156 0.052 3.497253e-61 CTL_MUT
## Lix1 1.264010e-64 -3.0285636 0.181 0.148 3.792029e-61 CTL_MUT
## Pde8b 1.320259e-64 -7.2916026 0.306 0.285 3.960778e-61 CTL_MUT
## Rnf217 1.601182e-64 -9.1023481 0.186 0.128 4.803546e-61 CTL_MUT
## Rasgrp3 1.676740e-64 -0.8931510 0.118 0.077 5.030221e-61 CTL_MUT
## 1700111E14Rik 1.716053e-64 -0.4038851 0.220 0.151 5.148158e-61 CTL_MUT
## Cdc42ep3 2.259512e-64 -5.5898366 0.123 0.051 6.778535e-61 CTL_MUT
## Cmya5 6.849999e-64 7.7161287 0.205 0.022 2.055000e-60 CTL_MUT
## Pag1 1.085991e-63 -2.5164187 0.155 0.112 3.257973e-60 CTL_MUT
## Gm44129 1.694667e-63 0.9767336 0.205 0.010 5.084001e-60 CTL_MUT
## Gjb2 3.614632e-63 -1.3479670 0.107 0.002 1.084389e-59 CTL_MUT
## Ppfibp2 5.364745e-63 12.2838717 0.119 0.064 1.609424e-59 CTL_MUT
## Nnat 1.634952e-62 0.4333676 0.190 0.124 4.904856e-59 CTL_MUT
## Vav3 1.865578e-62 -1.1693714 0.208 0.148 5.596735e-59 CTL_MUT
## Bdnf 2.966894e-62 5.4570589 0.208 0.143 8.900683e-59 CTL_MUT
## Gm32647 4.196021e-62 1.7698454 0.172 0.020 1.258806e-58 CTL_MUT
## Gas1 4.777435e-62 5.4288712 0.175 0.014 1.433230e-58 CTL_MUT
## Serping1 5.081921e-62 -0.6115223 0.119 0.007 1.524576e-58 CTL_MUT
## Cldn10 7.775257e-62 -0.7773031 0.126 0.090 2.332577e-58 CTL_MUT
## Eva1a 1.706324e-61 -0.2843718 0.108 0.028 5.118971e-58 CTL_MUT
## Zfp69 3.959811e-61 -0.4892766 0.131 0.003 1.187943e-57 CTL_MUT
## Slc30a1 5.721219e-61 -2.2639380 0.128 0.058 1.716366e-57 CTL_MUT
## Myom1 5.948331e-61 -1.1213625 0.229 0.008 1.784499e-57 CTL_MUT
## Josd2 1.321938e-60 -1.5665915 0.177 0.184 3.965815e-57 CTL_MUT
## Gm26917 1.571656e-60 -4.1028014 0.283 0.244 4.714967e-57 CTL_MUT
## Ppp1r16b 2.036270e-60 -7.6363154 0.219 0.201 6.108809e-57 CTL_MUT
## Txlnb 2.298312e-60 -0.8208244 0.239 0.005 6.894937e-57 CTL_MUT
## Slc7a2 2.637103e-60 -8.5194591 0.128 0.029 7.911310e-57 CTL_MUT
## Rtl4 3.304772e-60 -15.3579220 0.268 0.185 9.914317e-57 CTL_MUT
## Nek7 4.108053e-60 9.5776715 0.149 0.090 1.232416e-56 CTL_MUT
## Fgfrl1 4.410355e-60 5.4141360 0.214 0.005 1.323107e-56 CTL_MUT
## E130215H24Rik 9.642833e-60 -1.0632079 0.171 0.002 2.892850e-56 CTL_MUT
## Ppp1r14a 1.555554e-59 -4.0554005 0.136 0.161 4.666662e-56 CTL_MUT
## Nr4a2 2.737424e-59 7.0497051 0.170 0.130 8.212273e-56 CTL_MUT
## Ppp1r14b 3.322989e-59 -0.6460510 0.167 0.126 9.968966e-56 CTL_MUT
## Liph 4.392008e-59 2.4267129 0.108 0.004 1.317602e-55 CTL_MUT
## Gldc 6.983020e-59 -4.3521029 0.139 0.064 2.094906e-55 CTL_MUT
## Slc27a1 7.669173e-59 -0.2966335 0.142 0.102 2.300752e-55 CTL_MUT
## 9530026P05Rik 9.151038e-59 -3.3469457 0.117 0.058 2.745311e-55 CTL_MUT
## Plk5 1.059131e-58 -2.5975682 0.170 0.041 3.177393e-55 CTL_MUT
## Ifih1 1.233900e-58 -1.9693685 0.127 0.010 3.701699e-55 CTL_MUT
## Lgr6 1.568807e-58 -3.0034410 0.178 0.010 4.706422e-55 CTL_MUT
## Gm16267 1.722511e-58 -2.5169222 0.207 0.023 5.167534e-55 CTL_MUT
## Hmgn2 2.213661e-58 -1.3533604 0.179 0.088 6.640983e-55 CTL_MUT
## Pik3r6 2.255928e-58 -0.5927332 0.183 0.010 6.767784e-55 CTL_MUT
## Igfbp6 2.455373e-58 -1.1092766 0.164 0.132 7.366119e-55 CTL_MUT
## Mag 3.332356e-58 -1.5165262 0.129 0.164 9.997069e-55 CTL_MUT
## Fgd2 4.793341e-58 -5.3177751 0.101 0.012 1.438002e-54 CTL_MUT
## Sipa1 7.204732e-58 2.4451664 0.164 0.034 2.161420e-54 CTL_MUT
## Otx2os1 1.114455e-57 -4.1542079 0.118 0.002 3.343365e-54 CTL_MUT
## Mobp 1.407444e-57 -3.4649721 0.197 0.244 4.222332e-54 CTL_MUT
## Trim47 1.993611e-57 -4.7850744 0.147 0.008 5.980833e-54 CTL_MUT
## Lpin3 3.625808e-57 1.3556985 0.108 0.003 1.087742e-53 CTL_MUT
## Celrr 7.562470e-57 -8.7650062 0.117 0.023 2.268741e-53 CTL_MUT
## Col19a1 7.966396e-57 -2.2975064 0.123 0.065 2.389919e-53 CTL_MUT
## Gm48742 1.307307e-56 -3.6202525 0.177 0.063 3.921920e-53 CTL_MUT
## Slc32a1 2.505608e-56 2.0093264 0.110 0.052 7.516825e-53 CTL_MUT
## Ttyh1 3.333311e-56 1.2489873 0.263 0.282 9.999934e-53 CTL_MUT
## Ttyh2 3.562177e-56 0.7942488 0.112 0.074 1.068653e-52 CTL_MUT
## 4930445B16Rik 5.784207e-56 6.4295072 0.156 0.029 1.735262e-52 CTL_MUT
## Tprkb 7.000196e-56 -1.5471900 0.146 0.128 2.100059e-52 CTL_MUT
## Rapsn 9.143834e-56 0.5807881 0.195 0.004 2.743150e-52 CTL_MUT
## Tril 1.264120e-55 -1.5209205 0.135 0.065 3.792361e-52 CTL_MUT
## Slc44a5 1.806216e-55 3.9510806 0.235 0.166 5.418649e-52 CTL_MUT
## Rel 1.939608e-55 -0.5069125 0.107 0.074 5.818823e-52 CTL_MUT
## Maf 2.631441e-55 1.9586387 0.132 0.054 7.894323e-52 CTL_MUT
## 1700094D03Rik 3.216496e-55 6.2479436 0.249 0.011 9.649488e-52 CTL_MUT
## Gm48091 4.111658e-55 2.5439240 0.218 0.123 1.233497e-51 CTL_MUT
## Gadd45g 6.526464e-55 0.4712760 0.153 0.204 1.957939e-51 CTL_MUT
## Gm16006 9.844996e-55 -1.0725367 0.122 0.002 2.953499e-51 CTL_MUT
## Gja1 1.042822e-54 -4.0552127 0.133 0.132 3.128467e-51 CTL_MUT
## Smoc1 1.540317e-54 2.6953546 0.133 0.018 4.620952e-51 CTL_MUT
## Dach1 1.770663e-54 -1.3796896 0.144 0.053 5.311988e-51 CTL_MUT
## Gm29266 6.476318e-54 -0.3329875 0.144 0.003 1.942895e-50 CTL_MUT
## Gm49164 8.416255e-54 -2.5914440 0.173 0.012 2.524876e-50 CTL_MUT
## Fstl5 9.970790e-54 -3.1280786 0.164 0.066 2.991237e-50 CTL_MUT
## 9330111N05Rik 1.036068e-53 -3.3308982 0.179 0.015 3.108205e-50 CTL_MUT
## Pdgfrl 1.158254e-53 -1.5436366 0.142 0.009 3.474762e-50 CTL_MUT
## Sox13 1.327235e-53 -1.1713961 0.132 0.009 3.981706e-50 CTL_MUT
## Dock11 2.088765e-53 -0.5855037 0.181 0.074 6.266294e-50 CTL_MUT
## Dgkb 2.112839e-53 -3.1645343 0.360 0.331 6.338516e-50 CTL_MUT
## Gm9889 2.809497e-53 0.7972459 0.103 0.004 8.428492e-50 CTL_MUT
## Orai1 3.154073e-53 -7.1983669 0.135 0.057 9.462219e-50 CTL_MUT
## Gjc3 3.198282e-53 1.9587179 0.113 0.120 9.594847e-50 CTL_MUT
## Pnp 4.683946e-53 -7.8800501 0.159 0.039 1.405184e-49 CTL_MUT
## Lcat 5.136760e-53 -0.6003024 0.129 0.057 1.541028e-49 CTL_MUT
## Scpep1os 7.051286e-53 -1.0950523 0.208 0.012 2.115386e-49 CTL_MUT
## Cmtm5 7.284237e-53 1.3461448 0.149 0.162 2.185271e-49 CTL_MUT
## Bcl6 8.461823e-53 -9.9126722 0.167 0.087 2.538547e-49 CTL_MUT
## Bhlhe22 9.572616e-53 -3.9972342 0.179 0.087 2.871785e-49 CTL_MUT
## Ifi203 1.425281e-52 -1.7737836 0.147 0.005 4.275844e-49 CTL_MUT
## Gm28229 1.477085e-52 -1.3976940 0.123 0.002 4.431256e-49 CTL_MUT
## Mafb 1.588071e-52 -0.3866480 0.146 0.033 4.764212e-49 CTL_MUT
## Cntn2 2.822916e-52 0.9707979 0.134 0.135 8.468748e-49 CTL_MUT
## Tpm2 3.491311e-52 -0.9303066 0.128 0.012 1.047393e-48 CTL_MUT
## Ell2 5.610220e-52 -7.5020882 0.170 0.123 1.683066e-48 CTL_MUT
## Gm47283 1.178557e-51 -0.5533107 0.410 0.384 3.535670e-48 CTL_MUT
## Padi2 1.227614e-51 4.4029901 0.133 0.051 3.682842e-48 CTL_MUT
## 9630028H03Rik 1.304372e-51 -2.5126283 0.225 0.148 3.913115e-48 CTL_MUT
## Kctd12 1.438123e-51 -1.3060909 0.161 0.083 4.314369e-48 CTL_MUT
## Appl2 1.669836e-51 4.8603778 0.155 0.118 5.009509e-48 CTL_MUT
## Snhg18 2.754158e-51 -2.6587353 0.194 0.007 8.262473e-48 CTL_MUT
## Apod 3.289245e-51 0.2755398 0.127 0.151 9.867736e-48 CTL_MUT
## Tspan18 4.425872e-51 -2.6436696 0.130 0.053 1.327762e-47 CTL_MUT
## Nfe2l2 4.739389e-51 -9.2063772 0.119 0.074 1.421817e-47 CTL_MUT
## Acacb 5.480653e-51 -0.5511979 0.136 0.007 1.644196e-47 CTL_MUT
## Rprm 6.069961e-51 -2.1338427 0.156 0.059 1.820988e-47 CTL_MUT
## Vcl 6.755506e-51 3.9974344 0.192 0.171 2.026652e-47 CTL_MUT
## Elovl5 7.826569e-51 -13.3615327 0.172 0.114 2.347971e-47 CTL_MUT
## Slc7a14 2.188456e-50 3.2359284 0.267 0.234 6.565368e-47 CTL_MUT
## Hcst 3.138710e-50 -0.7937491 0.161 0.005 9.416129e-47 CTL_MUT
## Ctsd 3.809988e-50 0.9786119 0.266 0.290 1.142996e-46 CTL_MUT
## Gm20743 4.764098e-50 -2.9889697 0.152 0.014 1.429229e-46 CTL_MUT
## Rac2 6.731922e-50 3.0081581 0.103 0.006 2.019577e-46 CTL_MUT
## Nrap 9.167535e-50 1.9042125 0.103 0.003 2.750260e-46 CTL_MUT
## Myadml2os 1.045028e-49 -6.0152433 0.130 0.002 3.135085e-46 CTL_MUT
## Dio2 1.589752e-49 -4.5774537 0.100 0.063 4.769255e-46 CTL_MUT
## St18 1.595268e-49 -1.4324808 0.185 0.202 4.785805e-46 CTL_MUT
## Ddx60 1.637585e-49 1.3058558 0.162 0.004 4.912755e-46 CTL_MUT
## Sox2ot 2.414853e-49 -1.5740646 0.176 0.187 7.244560e-46 CTL_MUT
## Plp1 3.014098e-49 3.4321551 0.122 0.159 9.042295e-46 CTL_MUT
## Scn9a 8.077322e-49 3.9887462 0.100 0.031 2.423197e-45 CTL_MUT
## Adamts9 8.512079e-49 -1.9827250 0.135 0.044 2.553624e-45 CTL_MUT
## Apobec3 1.738673e-48 -2.0306794 0.105 0.013 5.216019e-45 CTL_MUT
## Cideb 4.741880e-48 -0.5684580 0.188 0.003 1.422564e-44 CTL_MUT
## Tpbgl 5.155825e-48 -1.1755916 0.149 0.004 1.546747e-44 CTL_MUT
## Megf10 5.496221e-48 1.2534164 0.113 0.079 1.648866e-44 CTL_MUT
## Pdzph1 6.276381e-48 -2.8286849 0.156 0.008 1.882914e-44 CTL_MUT
## Cldn11 1.054819e-47 1.8986745 0.116 0.143 3.164458e-44 CTL_MUT
## Pacrg 1.282657e-47 12.0278735 0.177 0.169 3.847970e-44 CTL_MUT
## Prdm16 1.799887e-47 4.2224879 0.113 0.057 5.399661e-44 CTL_MUT
## Taldo1 1.933721e-47 -0.5542153 0.227 0.247 5.801162e-44 CTL_MUT
## Lonrf3 2.167748e-47 -10.4144497 0.193 0.052 6.503245e-44 CTL_MUT
## Ctsl 2.453353e-47 -8.3118018 0.197 0.212 7.360060e-44 CTL_MUT
## Axl 3.412746e-47 -4.9235893 0.144 0.030 1.023824e-43 CTL_MUT
## Cachd1 3.971696e-47 4.7612674 0.161 0.099 1.191509e-43 CTL_MUT
## Mtus1 7.404107e-47 -7.1946876 0.161 0.071 2.221232e-43 CTL_MUT
## Neil3 7.754456e-47 -0.7893127 0.084 0.130 2.326337e-43 CTL_MUT
## Pik3r3 7.915470e-47 2.9874003 0.170 0.138 2.374641e-43 CTL_MUT
## Rasa4 1.015089e-46 -2.0147730 0.113 0.008 3.045266e-43 CTL_MUT
## Mfge8 1.621431e-46 1.1575442 0.175 0.181 4.864293e-43 CTL_MUT
## Bpgm 1.997696e-46 9.1630560 0.149 0.140 5.993088e-43 CTL_MUT
## Mgmt 2.382422e-46 -2.3904592 0.174 0.010 7.147266e-43 CTL_MUT
## Cttnbp2nl 2.634589e-46 -3.3849963 0.157 0.091 7.903767e-43 CTL_MUT
## Bank1 2.939273e-46 1.9948131 0.163 0.010 8.817818e-43 CTL_MUT
## Whrn 2.941103e-46 2.3858870 0.154 0.038 8.823309e-43 CTL_MUT
## Rgs12 2.986940e-46 -1.7156069 0.123 0.069 8.960821e-43 CTL_MUT
## Bcl11b 3.242681e-46 0.9193157 0.274 0.223 9.728043e-43 CTL_MUT
## Trp63 3.713330e-46 -1.9867777 0.127 0.004 1.113999e-42 CTL_MUT
## Tox3 3.945751e-46 -7.7109653 0.138 0.061 1.183725e-42 CTL_MUT
## Cyp7b1 4.000473e-46 -3.0587121 0.217 0.182 1.200142e-42 CTL_MUT
## Crybb1 4.250877e-46 3.9997272 0.121 0.020 1.275263e-42 CTL_MUT
## Fosb 5.682145e-46 4.4302232 0.156 0.137 1.704644e-42 CTL_MUT
## Zfp36l2 5.719741e-46 0.5586217 0.173 0.035 1.715922e-42 CTL_MUT
## Tanc1 8.135776e-46 1.9032458 0.292 0.255 2.440733e-42 CTL_MUT
## Aim2 1.101921e-45 4.3580463 0.198 0.046 3.305763e-42 CTL_MUT
## Gm13883 1.118629e-45 -14.3847315 0.136 0.047 3.355887e-42 CTL_MUT
## Iqgap1 1.276942e-45 -3.8267718 0.159 0.125 3.830827e-42 CTL_MUT
## Hip1 1.435476e-45 -1.9582961 0.186 0.176 4.306427e-42 CTL_MUT
## Enho 1.599870e-45 1.7188521 0.199 0.186 4.799611e-42 CTL_MUT
## Eomes 1.850391e-45 0.6946490 0.070 0.120 5.551173e-42 CTL_MUT
## Efnb3 2.701841e-45 -0.9373728 0.118 0.098 8.105523e-42 CTL_MUT
## Btg1 2.920705e-45 1.0498000 0.161 0.120 8.762115e-42 CTL_MUT
## Cartpt 3.767386e-45 -1.7959645 0.178 0.009 1.130216e-41 CTL_MUT
## Spaar 3.777482e-45 1.0234743 0.106 0.004 1.133245e-41 CTL_MUT
## AW047730 4.847436e-45 3.3830106 0.138 0.073 1.454231e-41 CTL_MUT
## A730036I17Rik 5.550173e-45 -0.3979421 0.117 0.003 1.665052e-41 CTL_MUT
## Card10 5.721364e-45 -5.0761154 0.163 0.010 1.716409e-41 CTL_MUT
## Gm13861 6.385379e-45 1.5515436 0.120 0.006 1.915614e-41 CTL_MUT
## Schip1 1.302688e-44 3.7068068 0.399 0.352 3.908063e-41 CTL_MUT
## Nrp2 1.373619e-44 -7.0259284 0.209 0.150 4.120857e-41 CTL_MUT
## Sec11c 1.704788e-44 -0.7192081 0.290 0.300 5.114363e-41 CTL_MUT
## Cd80 1.741648e-44 -1.2762386 0.108 0.009 5.224945e-41 CTL_MUT
## Cacnb2 2.124957e-44 -0.3005511 0.370 0.341 6.374870e-41 CTL_MUT
## Gm45904 3.343622e-44 -2.5722658 0.121 0.012 1.003086e-40 CTL_MUT
## Rnf144b 4.567210e-44 7.2804633 0.145 0.057 1.370163e-40 CTL_MUT
## Lpcat2 5.465821e-44 -3.8253168 0.139 0.050 1.639746e-40 CTL_MUT
## Fras1 6.570222e-44 2.4246439 0.173 0.096 1.971066e-40 CTL_MUT
## S1pr3 1.011654e-43 1.6844325 0.195 0.013 3.034963e-40 CTL_MUT
## Gm16564 1.031420e-43 -2.6477414 0.126 0.002 3.094259e-40 CTL_MUT
## Sst 1.458912e-43 2.3639926 0.263 0.273 4.376736e-40 CTL_MUT
## Gngt2 2.893101e-43 3.3062203 0.145 0.016 8.679303e-40 CTL_MUT
## Prkg1 3.740758e-43 -0.9802979 0.378 0.355 1.122228e-39 CTL_MUT
## Plekho1 4.412125e-43 3.1859466 0.160 0.102 1.323637e-39 CTL_MUT
## Camk2d 4.599449e-43 -3.8913821 0.184 0.164 1.379835e-39 CTL_MUT
## Ntn4 4.686841e-43 -1.4742282 0.165 0.015 1.406052e-39 CTL_MUT
## Pfkfb3 4.931949e-43 -9.2029261 0.165 0.062 1.479585e-39 CTL_MUT
## Aqp11 7.738778e-43 -6.4021142 0.162 0.039 2.321633e-39 CTL_MUT
## Arl15 8.271781e-43 -3.6167084 0.359 0.330 2.481534e-39 CTL_MUT
## Ube2c 1.107967e-42 -1.0709811 0.068 0.101 3.323900e-39 CTL_MUT
## Mfap4 1.255040e-42 -0.8669330 0.129 0.007 3.765121e-39 CTL_MUT
## Lst1 2.371247e-42 -10.0712714 0.162 0.030 7.113741e-39 CTL_MUT
## Slc35f3 2.981903e-42 -1.1449227 0.319 0.276 8.945708e-39 CTL_MUT
## Fbln2 3.108843e-42 -3.9550771 0.151 0.011 9.326529e-39 CTL_MUT
## Cd59a 4.998382e-42 1.2896203 0.116 0.027 1.499515e-38 CTL_MUT
## Dipk1c 5.212021e-42 3.4895534 0.134 0.012 1.563606e-38 CTL_MUT
## Gm26542 7.484212e-42 -2.2484289 0.171 0.055 2.245264e-38 CTL_MUT
## Ppfibp1 7.604194e-42 0.4349506 0.152 0.093 2.281258e-38 CTL_MUT
## Tspan2 7.692938e-42 -2.0166097 0.122 0.146 2.307881e-38 CTL_MUT
## Ranbp3l 8.728960e-42 -0.5017204 0.154 0.028 2.618688e-38 CTL_MUT
## 2810468N07Rik 9.155883e-42 2.6686868 0.120 0.088 2.746765e-38 CTL_MUT
## Sp110 9.391575e-42 0.7148503 0.100 0.006 2.817472e-38 CTL_MUT
## Phkg1 1.533092e-41 1.1338190 0.110 0.064 4.599275e-38 CTL_MUT
## Zfp462 1.534101e-41 -2.1393608 0.232 0.161 4.602303e-38 CTL_MUT
## Cox6b2 1.604966e-41 -2.7407000 0.195 0.015 4.814899e-38 CTL_MUT
## Tmem51 1.866215e-41 -2.8592646 0.157 0.010 5.598644e-38 CTL_MUT
## Pbk 1.866667e-41 4.7113166 0.077 0.132 5.600000e-38 CTL_MUT
## Nrg3os 2.774508e-41 -2.1099531 0.348 0.333 8.323525e-38 CTL_MUT
## Tsc22d4 4.464226e-41 1.3217995 0.161 0.116 1.339268e-37 CTL_MUT
## Kif13a 9.052198e-41 1.9637950 0.165 0.151 2.715659e-37 CTL_MUT
## D630033O11Rik 1.202719e-40 -6.0361984 0.134 0.006 3.608157e-37 CTL_MUT
## Csgalnact1 1.386297e-40 0.8306664 0.238 0.179 4.158890e-37 CTL_MUT
## S100a16 1.587965e-40 -2.2017382 0.189 0.192 4.763895e-37 CTL_MUT
## F730043M19Rik 1.590066e-40 4.3802682 0.173 0.083 4.770199e-37 CTL_MUT
## Bmp6 1.925884e-40 -2.3811914 0.198 0.010 5.777651e-37 CTL_MUT
## Dusp1 2.157806e-40 -0.2569337 0.161 0.167 6.473417e-37 CTL_MUT
## Gm6999 2.690358e-40 -2.1078599 0.112 0.019 8.071073e-37 CTL_MUT
## Rdx 3.324360e-40 0.5494402 0.237 0.242 9.973080e-37 CTL_MUT
## Rras 4.599715e-40 7.9205530 0.129 0.041 1.379915e-36 CTL_MUT
## Ddit3 6.684352e-40 5.3939078 0.175 0.144 2.005306e-36 CTL_MUT
## Mob3c 7.384506e-40 3.9437981 0.187 0.017 2.215352e-36 CTL_MUT
## Sox6 7.694649e-40 -2.6475635 0.135 0.127 2.308395e-36 CTL_MUT
## Tuba1c 8.063620e-40 -2.1066055 0.119 0.010 2.419086e-36 CTL_MUT
## St3gal4 8.784444e-40 -1.5444538 0.123 0.070 2.635333e-36 CTL_MUT
## Calb2 1.026758e-39 1.9531977 0.119 0.024 3.080273e-36 CTL_MUT
## Ndrg1 1.096505e-39 -0.9426293 0.137 0.143 3.289514e-36 CTL_MUT
## Tbc1d1 1.611354e-39 4.9701510 0.230 0.153 4.834062e-36 CTL_MUT
## Helz2 1.997318e-39 0.9308721 0.103 0.003 5.991955e-36 CTL_MUT
## Btg2 2.040617e-39 -2.3035956 0.171 0.132 6.121851e-36 CTL_MUT
## Mylip 3.459424e-39 -2.9052125 0.151 0.054 1.037827e-35 CTL_MUT
## Tex14 4.399574e-39 -0.5057463 0.230 0.010 1.319872e-35 CTL_MUT
## Mog 4.575335e-39 -0.7129838 0.117 0.142 1.372600e-35 CTL_MUT
## Plxnb1 4.651143e-39 0.2683616 0.159 0.061 1.395343e-35 CTL_MUT
## Mcc 5.155313e-39 4.2929794 0.190 0.149 1.546594e-35 CTL_MUT
## Olig1 6.089229e-39 -0.6412474 0.130 0.135 1.826769e-35 CTL_MUT
## Zfp503 8.423316e-39 -5.7144048 0.167 0.004 2.526995e-35 CTL_MUT
## Vamp8 9.532961e-39 -3.2582594 0.145 0.047 2.859888e-35 CTL_MUT
## Pde3a 9.768155e-39 -1.7338960 0.114 0.029 2.930446e-35 CTL_MUT
## Trim12c 1.015756e-38 -2.8681392 0.154 0.005 3.047268e-35 CTL_MUT
## Plekhb1 1.071804e-38 3.7501209 0.168 0.168 3.215413e-35 CTL_MUT
## Lockd 1.446860e-38 -3.6433652 0.116 0.030 4.340581e-35 CTL_MUT
## Gm35188 1.685332e-38 11.3669264 0.204 0.132 5.055996e-35 CTL_MUT
## Ano4 3.163996e-38 1.2715412 0.217 0.226 9.491988e-35 CTL_MUT
## Glra2 3.281867e-38 2.8069590 0.152 0.026 9.845602e-35 CTL_MUT
## Rasgrp2 4.166974e-38 2.1744532 0.162 0.040 1.250092e-34 CTL_MUT
## Calcrl 4.207157e-38 0.4390672 0.112 0.017 1.262147e-34 CTL_MUT
## Bcl2l1 4.280593e-38 -0.4049703 0.243 0.212 1.284178e-34 CTL_MUT
## Hck 4.912042e-38 0.6675844 0.122 0.023 1.473613e-34 CTL_MUT
## Fbxo2 6.861717e-38 -0.3161952 0.181 0.180 2.058515e-34 CTL_MUT
## Ifngr1 6.996066e-38 -4.7101331 0.137 0.030 2.098820e-34 CTL_MUT
## Lfng 8.367612e-38 -2.7494855 0.142 0.018 2.510284e-34 CTL_MUT
## Akna 8.976033e-38 -0.9585363 0.133 0.007 2.692810e-34 CTL_MUT
## Tgfbi 9.974088e-38 -1.9238080 0.102 0.005 2.992226e-34 CTL_MUT
## Epha7 1.160345e-37 -2.0741566 0.325 0.309 3.481036e-34 CTL_MUT
## Tmem176b 1.195458e-37 -1.6573667 0.152 0.085 3.586373e-34 CTL_MUT
## Sipa1l2 1.230098e-37 3.8962202 0.182 0.138 3.690295e-34 CTL_MUT
## Picalm 1.276407e-37 -6.5266790 0.218 0.218 3.829222e-34 CTL_MUT
## Gm28707 1.479749e-37 -0.9039262 0.101 0.004 4.439247e-34 CTL_MUT
## Golim4 1.908023e-37 4.5752409 0.187 0.077 5.724068e-34 CTL_MUT
## Gm34408 3.686965e-37 -1.2147616 0.102 0.003 1.106090e-33 CTL_MUT
## Slc6a11 4.319799e-37 -8.2914924 0.129 0.096 1.295940e-33 CTL_MUT
## Itga8 4.392761e-37 5.4653109 0.223 0.151 1.317828e-33 CTL_MUT
## Lrrc9 5.248193e-37 -2.2768781 0.123 0.004 1.574458e-33 CTL_MUT
## Mmp11 5.314428e-37 -0.9443032 0.133 0.003 1.594328e-33 CTL_MUT
## Bcas1 6.756633e-37 1.4913111 0.160 0.192 2.026990e-33 CTL_MUT
## Fam114a1 9.945019e-37 0.6436528 0.155 0.015 2.983506e-33 CTL_MUT
## Cdh9 1.072419e-36 0.9714068 0.252 0.201 3.217257e-33 CTL_MUT
## Trim12a 1.155825e-36 -3.0130104 0.151 0.011 3.467474e-33 CTL_MUT
## Arhgap31 1.229737e-36 -10.2597880 0.168 0.134 3.689210e-33 CTL_MUT
## Gm47423 1.377003e-36 -2.4497198 0.176 0.112 4.131008e-33 CTL_MUT
## Parvb 2.536239e-36 -5.5820226 0.171 0.052 7.608717e-33 CTL_MUT
## Gm15738 3.073725e-36 -8.3659101 0.273 0.239 9.221176e-33 CTL_MUT
## Thsd4 3.980780e-36 2.1514767 0.160 0.067 1.194234e-32 CTL_MUT
## Desi1 4.807446e-36 -0.7120513 0.232 0.235 1.442234e-32 CTL_MUT
## Plin2 5.033132e-36 -3.4706020 0.124 0.025 1.509940e-32 CTL_MUT
## Nrp1 6.834931e-36 -6.3103393 0.280 0.253 2.050479e-32 CTL_MUT
## Utp14b 8.305153e-36 4.3264554 0.139 0.076 2.491546e-32 CTL_MUT
## Entpd1 8.772845e-36 0.4424341 0.111 0.066 2.631854e-32 CTL_MUT
## Wasf2 9.670513e-36 -2.2843811 0.165 0.121 2.901154e-32 CTL_MUT
## Arhgap23 1.324529e-35 2.3508828 0.184 0.169 3.973587e-32 CTL_MUT
## Tmem88b 1.511845e-35 3.4347258 0.100 0.091 4.535535e-32 CTL_MUT
## Sapcd1 1.777142e-35 -2.0520116 0.105 0.004 5.331426e-32 CTL_MUT
## Ccdc114 1.895005e-35 -1.4962878 0.155 0.006 5.685016e-32 CTL_MUT
## Ypel2 2.902337e-35 -8.6346424 0.166 0.168 8.707010e-32 CTL_MUT
## Mir670hg 3.947539e-35 -2.5008266 0.182 0.067 1.184262e-31 CTL_MUT
## Cntnap4 6.083597e-35 -4.1017581 0.108 0.063 1.825079e-31 CTL_MUT
## Tead1 6.775352e-35 -0.3245721 0.219 0.175 2.032606e-31 CTL_MUT
## Disp3 7.464955e-35 -7.5364893 0.184 0.072 2.239487e-31 CTL_MUT
## Fcgr2b 1.198187e-34 1.4752725 0.112 0.004 3.594562e-31 CTL_MUT
## Gm28809 1.561565e-34 4.7545801 0.130 0.007 4.684694e-31 CTL_MUT
## Notch2 1.746245e-34 -4.7884256 0.170 0.056 5.238736e-31 CTL_MUT
## Rhoj 1.746575e-34 -5.2402015 0.103 0.037 5.239725e-31 CTL_MUT
## Frem1 1.998685e-34 -2.5757349 0.130 0.008 5.996056e-31 CTL_MUT
## Vamp5 2.909691e-34 -0.6930725 0.151 0.035 8.729072e-31 CTL_MUT
## Tbxa2r 3.370790e-34 -0.4292406 0.104 0.005 1.011237e-30 CTL_MUT
## Gask1a 4.159824e-34 -2.0354004 0.103 0.005 1.247947e-30 CTL_MUT
## Fjx1 4.415202e-34 -12.8313903 0.168 0.143 1.324561e-30 CTL_MUT
## Igfbp5 4.921855e-34 -2.6938614 0.161 0.135 1.476557e-30 CTL_MUT
## Clic4 6.685674e-34 -2.5840968 0.149 0.167 2.005702e-30 CTL_MUT
## Adamts16 8.317581e-34 -2.8534371 0.161 0.014 2.495274e-30 CTL_MUT
## Svep1 9.244371e-34 -0.5734270 0.118 0.002 2.773311e-30 CTL_MUT
## Fgf13 9.514889e-34 -1.7472943 0.213 0.208 2.854467e-30 CTL_MUT
## 9330175M20Rik 1.067627e-33 -7.5835974 0.181 0.024 3.202882e-30 CTL_MUT
## Ttc12 1.443904e-33 -1.6999574 0.153 0.007 4.331713e-30 CTL_MUT
## Dbx2 1.632294e-33 -12.9850557 0.123 0.049 4.896881e-30 CTL_MUT
## Kcnc1 1.870333e-33 3.2763497 0.210 0.184 5.610998e-30 CTL_MUT
## 4933424G05Rik 1.979470e-33 5.7322204 0.197 0.080 5.938411e-30 CTL_MUT
## Runx2 2.073822e-33 -2.6554369 0.256 0.194 6.221465e-30 CTL_MUT
## Anxa5 2.141136e-33 -3.3682936 0.163 0.075 6.423409e-30 CTL_MUT
## Trabd2b 2.209939e-33 4.1065699 0.156 0.048 6.629817e-30 CTL_MUT
## Eln 2.570407e-33 -3.9399462 0.140 0.006 7.711220e-30 CTL_MUT
## Thsd1 3.729555e-33 -1.7208876 0.141 0.019 1.118866e-29 CTL_MUT
## Fmo5 3.855274e-33 -0.4173156 0.186 0.008 1.156582e-29 CTL_MUT
## Ston2 4.220727e-33 -8.7251156 0.173 0.099 1.266218e-29 CTL_MUT
## Grm1 4.791741e-33 0.7769154 0.303 0.262 1.437522e-29 CTL_MUT
## Sulf1 4.830528e-33 -7.3305847 0.152 0.022 1.449158e-29 CTL_MUT
## Prkd1 5.301260e-33 1.8172134 0.223 0.210 1.590378e-29 CTL_MUT
## Nhsl1 6.190080e-33 3.9803054 0.152 0.108 1.857024e-29 CTL_MUT
## Dnajb2 6.523260e-33 -2.9608443 0.155 0.160 1.956978e-29 CTL_MUT
## Gm26887 1.115624e-32 -0.8787753 0.104 0.002 3.346872e-29 CTL_MUT
## Robo2 1.200037e-32 -1.2134764 0.360 0.347 3.600112e-29 CTL_MUT
## Rmst 2.051714e-32 -1.4557771 0.114 0.090 6.155141e-29 CTL_MUT
## Trps1 3.484966e-32 -10.5408840 0.230 0.216 1.045490e-28 CTL_MUT
## Ndst4 4.150205e-32 4.8419909 0.166 0.091 1.245061e-28 CTL_MUT
## Acer2 4.585681e-32 -0.9722318 0.109 0.023 1.375704e-28 CTL_MUT
## Cks2 4.689537e-32 -0.5092531 0.144 0.017 1.406861e-28 CTL_MUT
## Tafa1 4.853730e-32 -0.5476054 0.332 0.288 1.456119e-28 CTL_MUT
## Nme7 6.090900e-32 -3.9884138 0.409 0.368 1.827270e-28 CTL_MUT
## Rgs7 6.967294e-32 2.1750481 0.423 0.389 2.090188e-28 CTL_MUT
## Pon3 9.449072e-32 -1.9948513 0.143 0.004 2.834721e-28 CTL_MUT
## Fstl4 1.220262e-31 -9.1414835 0.327 0.279 3.660785e-28 CTL_MUT
## Kcnab1 2.389914e-31 0.7471640 0.317 0.307 7.169741e-28 CTL_MUT
## 9530059O14Rik 2.474533e-31 -17.5169961 0.294 0.244 7.423600e-28 CTL_MUT
## Fam129a 3.231998e-31 -0.8190674 0.105 0.013 9.695993e-28 CTL_MUT
## Ocln 3.410851e-31 -4.5475433 0.117 0.022 1.023255e-27 CTL_MUT
## Cyp2j9 3.513601e-31 -10.6523552 0.122 0.020 1.054080e-27 CTL_MUT
## Alpl 4.671295e-31 -2.8829805 0.148 0.010 1.401389e-27 CTL_MUT
## Myl2 5.181678e-31 -0.3435222 0.160 0.003 1.554503e-27 CTL_MUT
## Cd40 7.283957e-31 2.1470617 0.162 0.004 2.185187e-27 CTL_MUT
## Qk 7.681326e-31 -2.2383123 0.288 0.321 2.304398e-27 CTL_MUT
## Tmem164 1.244078e-30 7.1237080 0.160 0.105 3.732233e-27 CTL_MUT
## Fam107a 1.266279e-30 -5.0819052 0.161 0.120 3.798836e-27 CTL_MUT
## Hmmr 1.632291e-30 -1.2725655 0.101 0.078 4.896873e-27 CTL_MUT
## C1ql2 2.120891e-30 -1.4925192 0.168 0.067 6.362672e-27 CTL_MUT
## Kctd16 2.140813e-30 -4.4570389 0.414 0.373 6.422439e-27 CTL_MUT
## mt-Atp6 2.753639e-30 -0.3815891 0.507 0.449 8.260916e-27 CTL_MUT
## Trim14 2.957170e-30 -3.6665600 0.170 0.003 8.871509e-27 CTL_MUT
## Phactr4 3.177155e-30 0.9671463 0.129 0.062 9.531464e-27 CTL_MUT
## Renbp 3.355800e-30 -4.1548804 0.136 0.010 1.006740e-26 CTL_MUT
## Cpox 3.455683e-30 1.8252509 0.126 0.098 1.036705e-26 CTL_MUT
## Sntg1 3.507875e-30 -7.4076652 0.391 0.361 1.052363e-26 CTL_MUT
## Btk 3.585178e-30 -1.3654623 0.194 0.009 1.075553e-26 CTL_MUT
## Sorbs2 3.679327e-30 0.4260605 0.396 0.370 1.103798e-26 CTL_MUT
## Kcnb2 3.950324e-30 -2.0500667 0.388 0.346 1.185097e-26 CTL_MUT
## Glycam1 4.535622e-30 0.9764748 0.100 0.022 1.360687e-26 CTL_MUT
## Mlc1 4.762211e-30 3.1354334 0.148 0.106 1.428663e-26 CTL_MUT
## Gbp7 5.820750e-30 -0.9026506 0.107 0.017 1.746225e-26 CTL_MUT
## G430095P16Rik 6.992155e-30 -1.9207926 0.133 0.002 2.097646e-26 CTL_MUT
## Prelp 9.041853e-30 -0.9851829 0.117 0.020 2.712556e-26 CTL_MUT
## Lrp4 1.132628e-29 -7.0857583 0.113 0.045 3.397884e-26 CTL_MUT
## Psme1 1.225988e-29 5.7954307 0.155 0.090 3.677964e-26 CTL_MUT
## Sorcs3 1.350202e-29 -7.0236871 0.291 0.230 4.050607e-26 CTL_MUT
## Wdr17 1.407582e-29 -0.6945702 0.215 0.218 4.222746e-26 CTL_MUT
## Stac 1.452851e-29 -3.6637504 0.101 0.025 4.358552e-26 CTL_MUT
## Hectd2os 1.530025e-29 -7.6590424 0.212 0.148 4.590074e-26 CTL_MUT
## Efcab9 1.532573e-29 -5.1864194 0.132 0.002 4.597719e-26 CTL_MUT
## Timp4 1.738657e-29 -3.1609175 0.182 0.124 5.215970e-26 CTL_MUT
## Zic5 1.888804e-29 -4.3989464 0.140 0.009 5.666413e-26 CTL_MUT
## Parm1 1.932019e-29 -1.0792257 0.162 0.110 5.796057e-26 CTL_MUT
## Sgo1 3.391218e-29 -1.0923653 0.074 0.132 1.017365e-25 CTL_MUT
## Baz1a 4.105529e-29 -4.9197466 0.145 0.027 1.231659e-25 CTL_MUT
## Pde7b 4.591193e-29 5.9149012 0.281 0.243 1.377358e-25 CTL_MUT
## Snx29 5.920581e-29 3.4023856 0.199 0.176 1.776174e-25 CTL_MUT
## Cpne5 6.622134e-29 4.2788196 0.183 0.106 1.986640e-25 CTL_MUT
## Egfem1 7.011652e-29 -1.2720153 0.357 0.341 2.103496e-25 CTL_MUT
## 4930488L21Rik 7.316528e-29 -5.4584737 0.121 0.041 2.194958e-25 CTL_MUT
## Crlf3 7.400860e-29 -1.8550007 0.144 0.073 2.220258e-25 CTL_MUT
## Ophn1 7.537774e-29 1.7760514 0.205 0.173 2.261332e-25 CTL_MUT
## Hpgd 8.179940e-29 -1.1237438 0.102 0.016 2.453982e-25 CTL_MUT
## Tgm2 8.432870e-29 -1.8936003 0.103 0.017 2.529861e-25 CTL_MUT
## Gm30075 1.311386e-28 -0.8551780 0.105 0.003 3.934158e-25 CTL_MUT
## Rgs2 1.500143e-28 7.6437467 0.173 0.085 4.500428e-25 CTL_MUT
## Hdac8 1.525390e-28 -2.4524255 0.256 0.244 4.576170e-25 CTL_MUT
## Moxd1 2.401418e-28 -0.6784092 0.149 0.013 7.204254e-25 CTL_MUT
## Grip1os2 4.119451e-28 -1.6423228 0.101 0.030 1.235835e-24 CTL_MUT
## Gm49767 5.897826e-28 -1.1605863 0.104 0.004 1.769348e-24 CTL_MUT
## Eif2ak2 6.153265e-28 0.3524437 0.193 0.015 1.845979e-24 CTL_MUT
## Fzd7 6.868836e-28 -0.5484887 0.106 0.002 2.060651e-24 CTL_MUT
## Rreb1 6.891517e-28 3.3430183 0.202 0.093 2.067455e-24 CTL_MUT
## Gab1 8.389157e-28 1.1064103 0.151 0.122 2.516747e-24 CTL_MUT
## Kcns3 1.154236e-27 4.7820572 0.156 0.019 3.462708e-24 CTL_MUT
## Nptxr 1.275052e-27 -1.3083138 0.376 0.316 3.825155e-24 CTL_MUT
## Itgav 1.340131e-27 -5.7114423 0.174 0.168 4.020392e-24 CTL_MUT
## Mapk6 1.504770e-27 -1.2253361 0.149 0.123 4.514309e-24 CTL_MUT
## 4921511C10Rik 1.830010e-27 8.6966691 0.210 0.159 5.490031e-24 CTL_MUT
## Gem 1.878182e-27 -2.1398864 0.119 0.060 5.634546e-24 CTL_MUT
## Cntnap5a 2.165382e-27 -4.1755309 0.321 0.295 6.496147e-24 CTL_MUT
## Prex2 2.320892e-27 -2.9735532 0.178 0.186 6.962676e-24 CTL_MUT
## Dpp6 2.407947e-27 -0.4895593 0.417 0.382 7.223840e-24 CTL_MUT
## Rasl12 2.885219e-27 1.9333156 0.103 0.005 8.655658e-24 CTL_MUT
## A2m 3.135164e-27 0.6160905 0.111 0.072 9.405493e-24 CTL_MUT
## Tcf7l1 3.399373e-27 8.4774964 0.122 0.037 1.019812e-23 CTL_MUT
## Tenm2 3.431461e-27 -1.3540791 0.445 0.395 1.029438e-23 CTL_MUT
## Ucp2 4.097417e-27 -1.3532971 0.100 0.061 1.229225e-23 CTL_MUT
## Gbp3 4.361578e-27 -2.3644036 0.104 0.006 1.308473e-23 CTL_MUT
## Tmcc3 7.954473e-27 0.7563691 0.202 0.184 2.386342e-23 CTL_MUT
## Wscd1 8.436917e-27 0.3925373 0.159 0.159 2.531075e-23 CTL_MUT
## Smad3 8.700577e-27 -14.2459465 0.222 0.147 2.610173e-23 CTL_MUT
## Spock3 9.379149e-27 -7.2811976 0.206 0.183 2.813745e-23 CTL_MUT
## Nxph1 1.516919e-26 -0.3214216 0.102 0.098 4.550757e-23 CTL_MUT
## Grin2a 1.638550e-26 -1.3464904 0.446 0.393 4.915651e-23 CTL_MUT
## Npas1 1.734461e-26 1.9907917 0.133 0.015 5.203383e-23 CTL_MUT
## Ddo 1.854728e-26 -10.2179752 0.157 0.033 5.564183e-23 CTL_MUT
## Dlgap2 2.196928e-26 -10.8451899 0.460 0.404 6.590783e-23 CTL_MUT
## Sgms2 2.203308e-26 0.7517067 0.103 0.016 6.609925e-23 CTL_MUT
## Pla2g7 2.655475e-26 -4.7729031 0.148 0.128 7.966425e-23 CTL_MUT
## Atp1a1 2.949706e-26 -3.6068203 0.412 0.391 8.849118e-23 CTL_MUT
## Gria1 2.972683e-26 0.8997641 0.397 0.354 8.918050e-23 CTL_MUT
## Pde4b 3.183429e-26 -1.6191882 0.225 0.256 9.550286e-23 CTL_MUT
## Dock4 3.253376e-26 -0.5534733 0.406 0.399 9.760129e-23 CTL_MUT
## Hmgcs1 3.606435e-26 4.5815531 0.188 0.212 1.081930e-22 CTL_MUT
## Ralyl 4.369082e-26 -2.4177135 0.371 0.339 1.310725e-22 CTL_MUT
## Cyp4f15 4.858103e-26 -10.9893993 0.102 0.021 1.457431e-22 CTL_MUT
## Trp53cor1 5.012288e-26 -0.5417775 0.206 0.008 1.503686e-22 CTL_MUT
## Fgd6 7.007442e-26 1.3338509 0.131 0.040 2.102233e-22 CTL_MUT
## Lama5 7.022769e-26 -1.4945729 0.128 0.010 2.106831e-22 CTL_MUT
## Cpq 7.300719e-26 -6.2812825 0.155 0.052 2.190216e-22 CTL_MUT
## Cdr1 1.015612e-25 0.3892106 0.268 0.011 3.046836e-22 CTL_MUT
## Cacna2d3 1.037784e-25 -0.4672528 0.370 0.330 3.113353e-22 CTL_MUT
## Tppp3 1.079908e-25 -1.2028344 0.110 0.088 3.239723e-22 CTL_MUT
## Igsf11 1.082134e-25 -9.1116641 0.190 0.127 3.246403e-22 CTL_MUT
## Wwox 1.193972e-25 -2.5924952 0.288 0.279 3.581917e-22 CTL_MUT
## Bcan 1.209565e-25 3.5556144 0.218 0.226 3.628696e-22 CTL_MUT
## Csrp1 1.306959e-25 -6.0525013 0.170 0.215 3.920877e-22 CTL_MUT
## Gadd45b 1.402347e-25 -7.1876652 0.148 0.140 4.207040e-22 CTL_MUT
## Gm16201 1.500977e-25 -0.9460424 0.126 0.002 4.502932e-22 CTL_MUT
## Cd63 1.555690e-25 -3.4044767 0.250 0.257 4.667070e-22 CTL_MUT
## Col14a1 1.992537e-25 -1.7537296 0.110 0.003 5.977610e-22 CTL_MUT
## Rhou 2.298463e-25 1.7438977 0.139 0.126 6.895390e-22 CTL_MUT
## Ahcyl2 3.253362e-25 -2.0938140 0.300 0.298 9.760085e-22 CTL_MUT
## Cobl 3.765516e-25 2.2440762 0.228 0.185 1.129655e-21 CTL_MUT
## Traf1 3.976601e-25 -0.6886704 0.122 0.003 1.192980e-21 CTL_MUT
## Rgs10 4.571056e-25 3.3189088 0.130 0.098 1.371317e-21 CTL_MUT
## Gm29571 6.100107e-25 -2.0657986 0.104 0.002 1.830032e-21 CTL_MUT
## Lmo7 6.617720e-25 -2.5068278 0.266 0.231 1.985316e-21 CTL_MUT
## Golm1 6.638246e-25 1.9661859 0.196 0.095 1.991474e-21 CTL_MUT
## Opcml 7.431947e-25 -1.5256535 0.462 0.413 2.229584e-21 CTL_MUT
## Sphkap 7.694331e-25 -0.7027146 0.376 0.339 2.308299e-21 CTL_MUT
## Layn 8.732476e-25 -6.3027337 0.119 0.018 2.619743e-21 CTL_MUT
## Gm32036 1.096492e-24 -8.4142743 0.115 0.020 3.289476e-21 CTL_MUT
## Apcdd1 1.220752e-24 -5.8322145 0.127 0.040 3.662257e-21 CTL_MUT
## Atp2b1 1.552676e-24 -0.3630148 0.409 0.364 4.658028e-21 CTL_MUT
## Ccdc18 1.560561e-24 -1.6465281 0.218 0.007 4.681682e-21 CTL_MUT
## Gm12296 1.699686e-24 -9.0070143 0.164 0.090 5.099058e-21 CTL_MUT
## Smad7 1.795569e-24 10.6202397 0.163 0.145 5.386706e-21 CTL_MUT
## Dcc 1.847847e-24 -12.1427099 0.338 0.327 5.543541e-21 CTL_MUT
## Adamtsl1 1.904401e-24 10.7690237 0.128 0.061 5.713203e-21 CTL_MUT
## Ccdc85a 2.038636e-24 -2.1055552 0.302 0.256 6.115907e-21 CTL_MUT
## Bin1 2.169784e-24 -4.2757555 0.296 0.303 6.509351e-21 CTL_MUT
## Arhgdib 2.232961e-24 1.7776873 0.123 0.033 6.698884e-21 CTL_MUT
## Ptpn14 2.706543e-24 -4.9391263 0.105 0.018 8.119629e-21 CTL_MUT
## Exd1 2.929948e-24 -0.3073721 0.193 0.006 8.789844e-21 CTL_MUT
## Acsl3 3.034652e-24 2.2980872 0.269 0.292 9.103956e-21 CTL_MUT
## Brinp3 3.180585e-24 -3.9170352 0.220 0.222 9.541755e-21 CTL_MUT
## Slc24a3 3.201370e-24 -3.5471570 0.322 0.284 9.604111e-21 CTL_MUT
## Cacna1c 3.407726e-24 0.6279429 0.392 0.362 1.022318e-20 CTL_MUT
## Slain1 4.754877e-24 -2.6532798 0.139 0.131 1.426463e-20 CTL_MUT
## Ywhaq 5.166540e-24 -0.7007705 0.283 0.312 1.549962e-20 CTL_MUT
## Kcnk2 5.307433e-24 -1.7471290 0.230 0.195 1.592230e-20 CTL_MUT
## Aspm 5.474882e-24 -2.4915929 0.100 0.131 1.642465e-20 CTL_MUT
## Grin3a 8.925623e-24 -3.7062385 0.122 0.090 2.677687e-20 CTL_MUT
## Rad54b 9.786907e-24 -4.4611728 0.118 0.012 2.936072e-20 CTL_MUT
## St6galnac5 1.001079e-23 -1.3047031 0.365 0.339 3.003238e-20 CTL_MUT
## Ntng1 1.183986e-23 1.3863810 0.234 0.226 3.551959e-20 CTL_MUT
## Slc9a3r1 1.301489e-23 -1.2750230 0.171 0.041 3.904467e-20 CTL_MUT
## Gm40578 1.335997e-23 1.6645834 0.137 0.042 4.007990e-20 CTL_MUT
## Ccl5 1.371917e-23 -1.8723271 0.132 0.004 4.115752e-20 CTL_MUT
## Gbp2 1.529997e-23 -3.3420891 0.110 0.006 4.589991e-20 CTL_MUT
## Ntsr2 1.573928e-23 -1.1086118 0.192 0.213 4.721785e-20 CTL_MUT
## Epb41l4a 1.630811e-23 -4.7826928 0.185 0.019 4.892434e-20 CTL_MUT
## Cd38 1.810440e-23 -0.4575954 0.143 0.016 5.431320e-20 CTL_MUT
## Tagln2 1.900481e-23 -1.7737013 0.108 0.042 5.701443e-20 CTL_MUT
## Kif23 1.946041e-23 -0.5431682 0.180 0.039 5.838123e-20 CTL_MUT
## Etnppl 1.998033e-23 -2.5011629 0.130 0.014 5.994100e-20 CTL_MUT
## Plaat3 2.112954e-23 1.3441257 0.101 0.107 6.338861e-20 CTL_MUT
## Prkca 2.261502e-23 0.6834406 0.403 0.379 6.784506e-20 CTL_MUT
## Stmn1 2.443760e-23 -0.5300584 0.306 0.345 7.331281e-20 CTL_MUT
## 6330576A10Rik 2.523163e-23 -1.4666906 0.108 0.008 7.569489e-20 CTL_MUT
## Trim56 2.665941e-23 -2.3911650 0.138 0.010 7.997824e-20 CTL_MUT
## Gab2 2.903096e-23 5.4528056 0.151 0.118 8.709289e-20 CTL_MUT
## Gpr37l1 4.306725e-23 -1.7839768 0.166 0.181 1.292017e-19 CTL_MUT
## Gm20754 5.485557e-23 -0.3114280 0.304 0.264 1.645667e-19 CTL_MUT
## Tnfrsf13b 5.850041e-23 -1.5230742 0.115 0.005 1.755012e-19 CTL_MUT
## Epha6 7.092029e-23 0.6015032 0.324 0.295 2.127609e-19 CTL_MUT
## Fblim1 7.434246e-23 -3.0721152 0.140 0.005 2.230274e-19 CTL_MUT
## Gm26512 7.605998e-23 -0.8041812 0.103 0.041 2.281799e-19 CTL_MUT
## Slc13a3 8.458416e-23 -0.4594652 0.156 0.010 2.537525e-19 CTL_MUT
## Hs3st2 9.106417e-23 -3.6888332 0.133 0.098 2.731925e-19 CTL_MUT
## Gm28501 1.322250e-22 -1.5223383 0.197 0.010 3.966749e-19 CTL_MUT
## Cebpa 1.423755e-22 0.6856922 0.144 0.007 4.271265e-19 CTL_MUT
## Cyfip1 1.471631e-22 -5.1124847 0.278 0.255 4.414893e-19 CTL_MUT
## Abhd2 1.476112e-22 2.3796289 0.224 0.189 4.428336e-19 CTL_MUT
## Hunk 1.484179e-22 0.8805447 0.179 0.109 4.452536e-19 CTL_MUT
## Serpine1 1.576757e-22 -0.7460959 0.121 0.006 4.730272e-19 CTL_MUT
## Icosl 1.668176e-22 -0.2508497 0.165 0.011 5.004529e-19 CTL_MUT
## Fam214a 1.731988e-22 -6.8648926 0.183 0.138 5.195965e-19 CTL_MUT
## Dlx1as 1.778428e-22 -0.3687066 0.181 0.025 5.335285e-19 CTL_MUT
## Gm39556 2.154972e-22 -1.2822953 0.149 0.002 6.464916e-19 CTL_MUT
## Itgb1 2.189151e-22 0.8072384 0.183 0.161 6.567452e-19 CTL_MUT
## Slc25a34 2.418828e-22 1.6388355 0.100 0.004 7.256485e-19 CTL_MUT
## Atp1a3 2.756561e-22 -1.9315939 0.445 0.402 8.269683e-19 CTL_MUT
## Lpin2 3.634347e-22 -8.3096006 0.223 0.194 1.090304e-18 CTL_MUT
## Nav3 4.064563e-22 -0.4224917 0.442 0.397 1.219369e-18 CTL_MUT
## Rnf220 4.113262e-22 -4.7882736 0.226 0.223 1.233979e-18 CTL_MUT
## Serpinf1 4.329770e-22 -2.1046860 0.132 0.029 1.298931e-18 CTL_MUT
## Tmem88 4.643011e-22 -1.3902960 0.159 0.007 1.392903e-18 CTL_MUT
## Sox2 4.652077e-22 1.6585831 0.132 0.083 1.395623e-18 CTL_MUT
## Htr4 4.870937e-22 -3.0333874 0.198 0.130 1.461281e-18 CTL_MUT
## Zc3h12a 5.706790e-22 -1.7622724 0.103 0.010 1.712037e-18 CTL_MUT
## Elovl7 7.074220e-22 6.9411114 0.123 0.094 2.122266e-18 CTL_MUT
## Tnfsf13 8.941561e-22 4.4994182 0.140 0.006 2.682468e-18 CTL_MUT
## Fam155a 8.999832e-22 -0.3107122 0.456 0.408 2.699950e-18 CTL_MUT
## Tmem204 1.050164e-21 -4.4210388 0.139 0.026 3.150493e-18 CTL_MUT
## Gm36975 1.198788e-21 1.2853271 0.246 0.195 3.596365e-18 CTL_MUT
## Knl1 1.551577e-21 -2.0508361 0.123 0.060 4.654730e-18 CTL_MUT
## Cmtm8 1.639978e-21 2.8648875 0.113 0.018 4.919933e-18 CTL_MUT
## Evi2a 1.815895e-21 4.5765329 0.110 0.065 5.447685e-18 CTL_MUT
## Grn 1.864502e-21 2.6829381 0.139 0.101 5.593507e-18 CTL_MUT
## 4930474M22Rik 1.921312e-21 -0.3203394 0.121 0.005 5.763937e-18 CTL_MUT
## Chgb 2.124246e-21 -2.7990765 0.374 0.347 6.372737e-18 CTL_MUT
## Ucp3 2.500785e-21 0.3045196 0.113 0.003 7.502354e-18 CTL_MUT
## Spc25 2.553008e-21 -0.4469610 0.119 0.016 7.659024e-18 CTL_MUT
## Igsf6 2.583363e-21 -1.3757328 0.163 0.009 7.750089e-18 CTL_MUT
## Cotl1 2.905992e-21 2.6771340 0.192 0.114 8.717977e-18 CTL_MUT
## Dock1 3.062011e-21 0.9533502 0.196 0.164 9.186034e-18 CTL_MUT
## Ryr2 3.364804e-21 -0.3763699 0.437 0.399 1.009441e-17 CTL_MUT
## Kcnip4 4.677285e-21 -1.9126443 0.486 0.438 1.403185e-17 CTL_MUT
## Tec 5.377680e-21 4.7337134 0.101 0.017 1.613304e-17 CTL_MUT
## Gm20752 6.983373e-21 -1.8141802 0.124 0.057 2.095012e-17 CTL_MUT
## Art3 7.745288e-21 0.5598282 0.126 0.015 2.323586e-17 CTL_MUT
## Gm50048 8.888294e-21 -0.7451958 0.103 0.004 2.666488e-17 CTL_MUT
## Eps8 1.078994e-20 1.6512415 0.154 0.092 3.236981e-17 CTL_MUT
## 9630002D21Rik 1.234402e-20 1.5900154 0.105 0.007 3.703205e-17 CTL_MUT
## Foxn3 1.363695e-20 -0.8040016 0.312 0.362 4.091084e-17 CTL_MUT
## Carhsp1 1.556423e-20 2.6115042 0.108 0.080 4.669269e-17 CTL_MUT
## Sema6a 1.587283e-20 -2.0292561 0.147 0.126 4.761849e-17 CTL_MUT
## F13a1 1.588488e-20 0.6129052 0.163 0.004 4.765465e-17 CTL_MUT
## Kcnn2 1.649683e-20 -2.8586738 0.283 0.257 4.949048e-17 CTL_MUT
## Cyba 1.690976e-20 -1.0297598 0.125 0.080 5.072927e-17 CTL_MUT
## Gm20642 1.914282e-20 -3.7065216 0.275 0.226 5.742846e-17 CTL_MUT
## Slit3 1.967363e-20 -0.8353045 0.408 0.357 5.902090e-17 CTL_MUT
## Adipor2 2.164358e-20 11.0364277 0.141 0.126 6.493074e-17 CTL_MUT
## A830008E24Rik 2.242778e-20 0.2693189 0.117 0.007 6.728334e-17 CTL_MUT
## Ptprj 2.580562e-20 -4.2614339 0.361 0.339 7.741685e-17 CTL_MUT
## Dusp2 2.582449e-20 1.7908909 0.113 0.011 7.747347e-17 CTL_MUT
## Cort 2.767418e-20 -2.7413844 0.156 0.040 8.302253e-17 CTL_MUT
## Ryr3 3.509479e-20 -1.1176419 0.298 0.252 1.052844e-16 CTL_MUT
## Hist1h1e 3.514207e-20 10.3266226 0.149 0.057 1.054262e-16 CTL_MUT
## Clmn 3.590679e-20 -3.1200690 0.218 0.212 1.077204e-16 CTL_MUT
## Ninj2 5.169128e-20 -2.6713622 0.105 0.062 1.550738e-16 CTL_MUT
## Robo1 5.639327e-20 -6.2853906 0.288 0.265 1.691798e-16 CTL_MUT
## Amz1 5.868121e-20 2.1824188 0.105 0.016 1.760436e-16 CTL_MUT
## Fxyd1 6.375170e-20 -1.2204084 0.192 0.162 1.912551e-16 CTL_MUT
## Dnase2a 6.647276e-20 -4.2008855 0.229 0.011 1.994183e-16 CTL_MUT
## Ifrd1 7.194015e-20 -1.2171921 0.228 0.227 2.158204e-16 CTL_MUT
## Rfx3 8.640114e-20 -1.8063371 0.307 0.307 2.592034e-16 CTL_MUT
## Tmem130 9.231970e-20 8.4584954 0.191 0.147 2.769591e-16 CTL_MUT
## Nat8f3 9.523580e-20 -0.3703118 0.113 0.013 2.857074e-16 CTL_MUT
## Afap1l2 1.351765e-19 -2.9891058 0.168 0.027 4.055294e-16 CTL_MUT
## Sparc 1.394584e-19 -2.6378501 0.208 0.201 4.183751e-16 CTL_MUT
## Cyp2d22 1.931707e-19 -5.1932470 0.135 0.038 5.795120e-16 CTL_MUT
## Lpar1 1.932832e-19 1.6048201 0.103 0.099 5.798495e-16 CTL_MUT
## Cd44 1.975037e-19 -2.7672505 0.156 0.005 5.925112e-16 CTL_MUT
## Pmp22 2.132890e-19 4.4294142 0.153 0.088 6.398670e-16 CTL_MUT
## Dpyd 2.186720e-19 -1.3838313 0.211 0.145 6.560159e-16 CTL_MUT
## Psat1 2.227725e-19 -1.0166544 0.141 0.131 6.683174e-16 CTL_MUT
## Trpc5 2.755430e-19 2.9593792 0.236 0.181 8.266289e-16 CTL_MUT
## Cntn5 3.300866e-19 -1.7180817 0.314 0.293 9.902599e-16 CTL_MUT
## Wwtr1 3.959942e-19 6.6702074 0.152 0.061 1.187983e-15 CTL_MUT
## S100a6 5.824061e-19 -2.1038331 0.159 0.100 1.747218e-15 CTL_MUT
## Nr2f2 6.513721e-19 -5.3974761 0.111 0.024 1.954116e-15 CTL_MUT
## Fign 6.809997e-19 -4.1841213 0.104 0.045 2.042999e-15 CTL_MUT
## Ndc80 7.502461e-19 -0.8015188 0.106 0.002 2.250738e-15 CTL_MUT
## Jun 7.534902e-19 -1.8241728 0.269 0.298 2.260471e-15 CTL_MUT
## Dgkg 7.948139e-19 1.0766454 0.315 0.264 2.384442e-15 CTL_MUT
## Pdk4 8.186896e-19 -1.3199187 0.155 0.008 2.456069e-15 CTL_MUT
## Ogn 8.468177e-19 -1.9664331 0.153 0.006 2.540453e-15 CTL_MUT
## Pou2f2 1.018432e-18 -8.7900389 0.180 0.117 3.055295e-15 CTL_MUT
## Gm10754 1.102230e-18 1.7980169 0.166 0.043 3.306690e-15 CTL_MUT
## Hist1h2ap 1.289487e-18 5.3888409 0.190 0.012 3.868462e-15 CTL_MUT
## Abca8a 1.473008e-18 -2.7095444 0.131 0.017 4.419025e-15 CTL_MUT
## F3 1.712898e-18 -2.7298724 0.102 0.055 5.138693e-15 CTL_MUT
## Prkce 2.266878e-18 -0.5620222 0.431 0.400 6.800635e-15 CTL_MUT
## Cxcl14 2.386068e-18 -3.4483980 0.156 0.140 7.158203e-15 CTL_MUT
## Bst2 3.040937e-18 -0.4542604 0.145 0.014 9.122810e-15 CTL_MUT
## Gm10848 3.040937e-18 -1.8533542 0.175 0.065 9.122810e-15 CTL_MUT
## Car8 3.424380e-18 0.6855338 0.118 0.009 1.027314e-14 CTL_MUT
## Maml3 4.025466e-18 -2.7746378 0.306 0.258 1.207640e-14 CTL_MUT
## Galnt17 4.413178e-18 -1.6326663 0.369 0.341 1.323953e-14 CTL_MUT
## Rbfox1 5.718812e-18 -2.4036305 0.450 0.411 1.715644e-14 CTL_MUT
## Gm28750 5.990069e-18 -3.6306041 0.180 0.034 1.797021e-14 CTL_MUT
## Cd34 6.141122e-18 -0.5988989 0.167 0.100 1.842337e-14 CTL_MUT
## Inpp4b 6.173269e-18 -7.8145868 0.220 0.173 1.851981e-14 CTL_MUT
## Isg15 6.506569e-18 -2.6801487 0.122 0.008 1.951971e-14 CTL_MUT
## Plxna4 7.247708e-18 -0.2652870 0.391 0.371 2.174312e-14 CTL_MUT
## Mia 7.296982e-18 -1.2878569 0.139 0.009 2.189095e-14 CTL_MUT
## Palld 7.833669e-18 -2.2327173 0.146 0.033 2.350101e-14 CTL_MUT
## Rasgrf2 8.280146e-18 -0.5279644 0.263 0.209 2.484044e-14 CTL_MUT
## Bmp2k 8.718931e-18 6.9726667 0.167 0.100 2.615679e-14 CTL_MUT
## Olfm3 9.277811e-18 -1.3334690 0.160 0.101 2.783343e-14 CTL_MUT
## Ust 1.072676e-17 -3.7180946 0.226 0.190 3.218029e-14 CTL_MUT
## Osgin1 1.169373e-17 1.3198823 0.134 0.004 3.508118e-14 CTL_MUT
## Cd5 1.371759e-17 -0.4356297 0.112 0.002 4.115276e-14 CTL_MUT
## Cdca8 1.448991e-17 0.4549737 0.213 0.034 4.346974e-14 CTL_MUT
## Grb14 1.516337e-17 4.0522758 0.188 0.183 4.549012e-14 CTL_MUT
## Tmem140 1.558190e-17 1.3603633 0.115 0.015 4.674571e-14 CTL_MUT
## Clspn 1.632601e-17 -3.6524739 0.198 0.018 4.897802e-14 CTL_MUT
## Bfsp2 1.673510e-17 -0.2595320 0.105 0.069 5.020530e-14 CTL_MUT
## Hs3st5 1.701901e-17 -11.6186417 0.122 0.064 5.105703e-14 CTL_MUT
## Fgd3 1.728077e-17 4.7013194 0.118 0.030 5.184231e-14 CTL_MUT
## Abcc6 1.788919e-17 -0.2889473 0.105 0.005 5.366758e-14 CTL_MUT
## Gm9968 2.059934e-17 -1.2328129 0.182 0.019 6.179802e-14 CTL_MUT
## Ttll7 2.124641e-17 -1.0081043 0.330 0.336 6.373924e-14 CTL_MUT
## Ikbke 2.172139e-17 -0.8411071 0.182 0.005 6.516418e-14 CTL_MUT
## Egfl8 2.365771e-17 -2.2592520 0.205 0.007 7.097313e-14 CTL_MUT
## Itga9 2.989984e-17 -2.2132291 0.120 0.037 8.969952e-14 CTL_MUT
## Mmp14 3.292128e-17 -6.6845517 0.142 0.011 9.876383e-14 CTL_MUT
## Ntrk2 3.587385e-17 -2.5204226 0.402 0.387 1.076216e-13 CTL_MUT
## Fzd6 4.304467e-17 7.8767022 0.108 0.021 1.291340e-13 CTL_MUT
## Npy 4.729488e-17 2.1232623 0.227 0.231 1.418846e-13 CTL_MUT
## Rflnb 4.823484e-17 -5.3376851 0.172 0.037 1.447045e-13 CTL_MUT
## Gm31592 5.046329e-17 -1.2586873 0.146 0.002 1.513899e-13 CTL_MUT
## Grm7 5.170592e-17 -0.9677692 0.416 0.387 1.551178e-13 CTL_MUT
## Rftn2 5.472335e-17 2.6850591 0.130 0.049 1.641701e-13 CTL_MUT
## 4930505G20Rik 5.978337e-17 -4.0011251 0.133 0.004 1.793501e-13 CTL_MUT
## Sema6d 8.441351e-17 -0.3144173 0.332 0.348 2.532405e-13 CTL_MUT
## Otud7b 1.019248e-16 -1.7778384 0.199 0.182 3.057743e-13 CTL_MUT
## Sln 1.033086e-16 -2.0776104 0.183 0.034 3.099259e-13 CTL_MUT
## Myo1b 1.161243e-16 -8.3024361 0.165 0.068 3.483730e-13 CTL_MUT
## Acat3 1.211762e-16 -1.1476965 0.164 0.011 3.635287e-13 CTL_MUT
## Slc1a5 1.279040e-16 -1.1018766 0.147 0.004 3.837119e-13 CTL_MUT
## Ndrg2 1.467817e-16 0.8137808 0.250 0.293 4.403452e-13 CTL_MUT
## Gm4890 1.516697e-16 -2.6303424 0.150 0.004 4.550091e-13 CTL_MUT
## Syn3 1.721656e-16 1.4848727 0.277 0.240 5.164968e-13 CTL_MUT
## Daam2 1.781793e-16 3.8770121 0.138 0.132 5.345379e-13 CTL_MUT
## Nrg3 1.841958e-16 1.7914293 0.480 0.436 5.525873e-13 CTL_MUT
## Atf3 2.006760e-16 1.3469810 0.139 0.139 6.020279e-13 CTL_MUT
## Csf1 2.015606e-16 -1.5814047 0.111 0.062 6.046818e-13 CTL_MUT
## Cald1 2.683427e-16 -1.5033042 0.179 0.163 8.050282e-13 CTL_MUT
## Arl4a 3.364458e-16 8.2225245 0.142 0.137 1.009337e-12 CTL_MUT
## Adcy8 3.950523e-16 -2.8623785 0.185 0.158 1.185157e-12 CTL_MUT
## Ramp2 4.104028e-16 2.9897165 0.108 0.081 1.231209e-12 CTL_MUT
## S100b 4.196928e-16 -4.9889787 0.208 0.196 1.259078e-12 CTL_MUT
## Errfi1 4.926101e-16 -2.8302836 0.184 0.127 1.477830e-12 CTL_MUT
## Nkain3 5.549291e-16 3.4983277 0.232 0.191 1.664787e-12 CTL_MUT
## Pde11a 5.988768e-16 1.6523093 0.111 0.012 1.796631e-12 CTL_MUT
## Iqgap2 6.360780e-16 -0.4341991 0.330 0.282 1.908234e-12 CTL_MUT
## Mmp2 7.016201e-16 -1.4438262 0.141 0.006 2.104860e-12 CTL_MUT
## Ceacam1 7.592242e-16 0.7818620 0.156 0.013 2.277673e-12 CTL_MUT
## Plekhg2 8.055612e-16 -1.9313526 0.133 0.007 2.416684e-12 CTL_MUT
## Asb2 9.162726e-16 -1.0730905 0.138 0.004 2.748818e-12 CTL_MUT
## Zfp804b 9.715429e-16 -0.8025278 0.148 0.116 2.914629e-12 CTL_MUT
## Gm9750 9.835874e-16 2.3278158 0.141 0.011 2.950762e-12 CTL_MUT
## Ppfia2 1.073908e-15 -0.7275219 0.381 0.360 3.221724e-12 CTL_MUT
## Kank1 1.283186e-15 2.2125932 0.111 0.079 3.849558e-12 CTL_MUT
## Vit 1.294819e-15 -1.5381229 0.111 0.005 3.884457e-12 CTL_MUT
## Cdh13 1.314636e-15 -1.3710792 0.180 0.158 3.943907e-12 CTL_MUT
## Inava 1.336548e-15 -4.6790183 0.103 0.025 4.009645e-12 CTL_MUT
## Trpm3 1.385008e-15 2.2680660 0.320 0.313 4.155024e-12 CTL_MUT
## Tac2 1.454539e-15 -0.5458861 0.117 0.013 4.363617e-12 CTL_MUT
## Cspg5 1.552503e-15 -4.2239692 0.253 0.277 4.657508e-12 CTL_MUT
## Grik4 1.585513e-15 0.7033774 0.238 0.206 4.756540e-12 CTL_MUT
## Sox5os4 1.586911e-15 -10.6465427 0.100 0.020 4.760733e-12 CTL_MUT
## Gm17590 1.619415e-15 -0.4488298 0.134 0.003 4.858244e-12 CTL_MUT
## Kcnd2 1.798784e-15 -0.4356816 0.430 0.396 5.396353e-12 CTL_MUT
## Pappa 1.817504e-15 -2.4731049 0.133 0.009 5.452513e-12 CTL_MUT
## Dchs2 2.002022e-15 -1.4569942 0.128 0.016 6.006067e-12 CTL_MUT
## Kcnj16 2.243730e-15 4.1193259 0.151 0.029 6.731189e-12 CTL_MUT
## Crip2 2.496824e-15 3.6245923 0.240 0.248 7.490471e-12 CTL_MUT
## Cenpf 2.800503e-15 -1.4512105 0.134 0.012 8.401510e-12 CTL_MUT
## 4930509J09Rik 2.825265e-15 -0.9865040 0.195 0.089 8.475796e-12 CTL_MUT
## Zfp536 3.275617e-15 3.8276279 0.211 0.243 9.826852e-12 CTL_MUT
## Abca1 3.521106e-15 9.4700490 0.151 0.085 1.056332e-11 CTL_MUT
## Gna13 4.088067e-15 -6.3735675 0.173 0.111 1.226420e-11 CTL_MUT
## Tafa2 4.376360e-15 -3.1283862 0.312 0.288 1.312908e-11 CTL_MUT
## Ptprg 4.857957e-15 -7.7694461 0.333 0.325 1.457387e-11 CTL_MUT
## Def6 5.019479e-15 0.3149226 0.122 0.007 1.505844e-11 CTL_MUT
## Gad2 5.238611e-15 -2.5766006 0.120 0.085 1.571583e-11 CTL_MUT
## Cdk19 5.243216e-15 -1.7866987 0.209 0.206 1.572965e-11 CTL_MUT
## Tgfb2 6.620985e-15 4.0661384 0.171 0.089 1.986295e-11 CTL_MUT
## Chd7 6.807438e-15 -0.3025654 0.169 0.156 2.042231e-11 CTL_MUT
## Dll4 7.102317e-15 0.4983948 0.123 0.004 2.130695e-11 CTL_MUT
## 4930419G24Rik 7.120206e-15 -1.7513468 0.215 0.146 2.136062e-11 CTL_MUT
## Olfml1 7.533292e-15 -10.5543338 0.104 0.037 2.259987e-11 CTL_MUT
## Rbpms2 8.570206e-15 -1.9849111 0.131 0.005 2.571062e-11 CTL_MUT
## Khdrbs2 9.305097e-15 -1.0591652 0.270 0.244 2.791529e-11 CTL_MUT
## Ptma 9.379241e-15 -8.5946373 0.332 0.363 2.813772e-11 CTL_MUT
## Kif19a 9.966386e-15 2.4342780 0.123 0.008 2.989916e-11 CTL_MUT
## Nrxn3 1.045204e-14 -3.5413300 0.399 0.356 3.135613e-11 CTL_MUT
## Homer1 1.046288e-14 0.7827364 0.258 0.267 3.138864e-11 CTL_MUT
## Stxbp6 1.186042e-14 -0.6655014 0.283 0.301 3.558126e-11 CTL_MUT
## Sdk1 1.221401e-14 -2.6176986 0.186 0.101 3.664203e-11 CTL_MUT
## Gstm1 1.285089e-14 1.7423617 0.232 0.243 3.855268e-11 CTL_MUT
## Unc13c 1.328995e-14 4.8858429 0.136 0.076 3.986985e-11 CTL_MUT
## Csrp2 1.339729e-14 -1.8509422 0.105 0.034 4.019188e-11 CTL_MUT
## Ddah2 1.495246e-14 6.1551958 0.160 0.034 4.485739e-11 CTL_MUT
## E230029C05Rik 1.584582e-14 6.8014074 0.132 0.072 4.753747e-11 CTL_MUT
## Syt11 1.668204e-14 -0.2579114 0.364 0.389 5.004612e-11 CTL_MUT
## Dusp10 1.874402e-14 -5.3389040 0.112 0.068 5.623207e-11 CTL_MUT
## Fos 1.915838e-14 -0.7409521 0.237 0.275 5.747513e-11 CTL_MUT
## Slc7a15 1.935968e-14 -0.9589851 0.231 0.005 5.807905e-11 CTL_MUT
## Tns3 1.943416e-14 -0.8817834 0.147 0.091 5.830248e-11 CTL_MUT
## Rrbp1 2.075384e-14 -2.8595443 0.241 0.227 6.226153e-11 CTL_MUT
## Tuba1a 2.405823e-14 -3.9245465 0.352 0.380 7.217470e-11 CTL_MUT
## Zfp521 3.439967e-14 -0.2699767 0.142 0.047 1.031990e-10 CTL_MUT
## Klf10 3.743982e-14 -0.9130544 0.164 0.074 1.123194e-10 CTL_MUT
## Egr1 3.829484e-14 -11.3643813 0.310 0.328 1.148845e-10 CTL_MUT
## Dmrta2os 6.029966e-14 0.2695549 0.109 0.002 1.808990e-10 CTL_MUT
## Spata13 6.842084e-14 -12.8016090 0.169 0.052 2.052625e-10 CTL_MUT
## Phgdh 7.044785e-14 3.9640931 0.150 0.130 2.113435e-10 CTL_MUT
## Pdlim2 8.022290e-14 1.4470577 0.114 0.122 2.406687e-10 CTL_MUT
## Grik2 8.628483e-14 -4.5095363 0.374 0.376 2.588545e-10 CTL_MUT
## Dock10 9.640509e-14 2.6607670 0.278 0.299 2.892153e-10 CTL_MUT
## Rhob 9.858162e-14 -9.0922786 0.229 0.220 2.957449e-10 CTL_MUT
## Gm41492 1.108529e-13 1.9095546 0.125 0.006 3.325587e-10 CTL_MUT
## A230006K03Rik 1.171876e-13 -2.5116228 0.220 0.169 3.515629e-10 CTL_MUT
## Frmpd4 1.189795e-13 2.7967687 0.366 0.347 3.569386e-10 CTL_MUT
## Etv4 1.230822e-13 -3.3723709 0.123 0.019 3.692465e-10 CTL_MUT
## Gm36988 1.262137e-13 -0.7482136 0.177 0.017 3.786412e-10 CTL_MUT
## Cep112 1.298668e-13 1.2784731 0.182 0.151 3.896003e-10 CTL_MUT
## Sgcd 1.317983e-13 -3.8968326 0.197 0.162 3.953949e-10 CTL_MUT
## Gm9925 1.352083e-13 -4.9334240 0.142 0.042 4.056250e-10 CTL_MUT
## 3110082J24Rik 1.403354e-13 0.3612461 0.207 0.012 4.210063e-10 CTL_MUT
## Asap3 1.499180e-13 -2.1475615 0.183 0.012 4.497541e-10 CTL_MUT
## Arid5a 1.612761e-13 5.3826796 0.140 0.040 4.838282e-10 CTL_MUT
## Adgrb3 1.628306e-13 -1.2078609 0.448 0.414 4.884919e-10 CTL_MUT
## Lxn 1.686079e-13 3.2941925 0.142 0.088 5.058236e-10 CTL_MUT
## Tenm3 1.945747e-13 -3.5479341 0.280 0.259 5.837240e-10 CTL_MUT
## Oasl2 2.160531e-13 0.5963232 0.130 0.007 6.481593e-10 CTL_MUT
## Polr3e 2.257420e-13 4.9998620 0.117 0.083 6.772259e-10 CTL_MUT
## BC035044 2.365604e-13 -2.1217484 0.120 0.005 7.096813e-10 CTL_MUT
## Nupr1 2.559884e-13 2.1988954 0.160 0.031 7.679653e-10 CTL_MUT
## Dach2 2.610832e-13 -2.7041896 0.160 0.044 7.832497e-10 CTL_MUT
## Slc16a9 2.719105e-13 -2.6671655 0.118 0.008 8.157316e-10 CTL_MUT
## Scd2 2.728828e-13 -1.3297498 0.300 0.331 8.186484e-10 CTL_MUT
## Tbxas1 3.326946e-13 -1.1248823 0.110 0.017 9.980839e-10 CTL_MUT
## Swap70 3.349301e-13 0.4960463 0.110 0.052 1.004790e-09 CTL_MUT
## Dok1 3.713020e-13 1.7431477 0.192 0.004 1.113906e-09 CTL_MUT
## Gbp5 3.986702e-13 -1.9865792 0.105 0.004 1.196011e-09 CTL_MUT
## Ccnd2 4.199455e-13 -2.1693188 0.225 0.179 1.259837e-09 CTL_MUT
## Tgfbr2 4.273107e-13 -2.0904474 0.105 0.051 1.281932e-09 CTL_MUT
## Nyap2 4.641779e-13 -1.2852658 0.215 0.168 1.392534e-09 CTL_MUT
## Pcsk2 4.909811e-13 -0.2533446 0.419 0.387 1.472943e-09 CTL_MUT
## Abtb2 5.839270e-13 4.7300150 0.162 0.058 1.751781e-09 CTL_MUT
## Gm26619 6.428508e-13 -1.7741651 0.108 0.004 1.928552e-09 CTL_MUT
## Tnfaip8l2 7.179436e-13 -2.1468206 0.112 0.005 2.153831e-09 CTL_MUT
## Zfp691 7.343728e-13 -1.9087767 0.203 0.007 2.203118e-09 CTL_MUT
## Rab3b 8.461999e-13 0.3734211 0.151 0.032 2.538600e-09 CTL_MUT
## Pbxip1 8.469767e-13 3.3315354 0.161 0.073 2.540930e-09 CTL_MUT
## Gprc5b 8.821213e-13 1.1950862 0.134 0.114 2.646364e-09 CTL_MUT
## Gm16183 8.982156e-13 -3.3998277 0.175 0.087 2.694647e-09 CTL_MUT
## Il15 9.558411e-13 -3.0033169 0.156 0.008 2.867523e-09 CTL_MUT
## Kit 9.588080e-13 -0.3795567 0.111 0.035 2.876424e-09 CTL_MUT
## Litaf 9.770657e-13 -4.8970462 0.127 0.102 2.931197e-09 CTL_MUT
## Cpm 1.050939e-12 -3.7978807 0.101 0.048 3.152817e-09 CTL_MUT
## Insyn2b 1.055368e-12 -0.4418726 0.117 0.007 3.166103e-09 CTL_MUT
## Lgmn 1.110495e-12 -4.4047157 0.114 0.087 3.331486e-09 CTL_MUT
## Bdh2 1.114647e-12 1.9559794 0.172 0.004 3.343941e-09 CTL_MUT
## Itpripl2 1.240370e-12 -3.6111051 0.186 0.013 3.721109e-09 CTL_MUT
## Col18a1 1.322906e-12 -1.5973227 0.105 0.004 3.968717e-09 CTL_MUT
## Myh9 1.326677e-12 -7.1968482 0.198 0.168 3.980031e-09 CTL_MUT
## Fads2 1.428458e-12 -2.2735916 0.158 0.102 4.285375e-09 CTL_MUT
## C1ql3 1.459875e-12 -0.6602224 0.355 0.349 4.379624e-09 CTL_MUT
## Pdlim5 1.464765e-12 0.3724965 0.147 0.104 4.394296e-09 CTL_MUT
## Soat1 1.512201e-12 4.2259144 0.155 0.084 4.536602e-09 CTL_MUT
## Peli2 1.638301e-12 -3.0299315 0.175 0.100 4.914902e-09 CTL_MUT
## Ctsa 1.642499e-12 -13.2378826 0.175 0.145 4.927497e-09 CTL_MUT
## Maob 1.773832e-12 -2.9825313 0.144 0.034 5.321496e-09 CTL_MUT
## Cdh12 1.891414e-12 1.0222340 0.285 0.252 5.674243e-09 CTL_MUT
## Hspb8 2.095554e-12 4.9032019 0.136 0.014 6.286663e-09 CTL_MUT
## Gfap 2.283818e-12 2.9686681 0.146 0.124 6.851454e-09 CTL_MUT
## Gm41031 2.719025e-12 -5.2220342 0.181 0.012 8.157075e-09 CTL_MUT
## Acot11 2.924686e-12 0.5974528 0.116 0.034 8.774059e-09 CTL_MUT
## Mmp28 2.940510e-12 -0.3438066 0.145 0.007 8.821530e-09 CTL_MUT
## Sema5b 2.963030e-12 -4.9961526 0.138 0.074 8.889091e-09 CTL_MUT
## Slc16a12 3.021610e-12 1.5815635 0.113 0.009 9.064829e-09 CTL_MUT
## Itga6 3.468871e-12 -7.8351253 0.127 0.082 1.040661e-08 CTL_MUT
## Fgf14 3.652305e-12 -0.3477015 0.445 0.416 1.095691e-08 CTL_MUT
## Stom 3.746888e-12 -9.0011035 0.149 0.010 1.124066e-08 CTL_MUT
## Adamts18 4.044939e-12 1.2022878 0.146 0.013 1.213482e-08 CTL_MUT
## Ninj1 4.073887e-12 -10.3268077 0.153 0.049 1.222166e-08 CTL_MUT
## Negr1 4.160877e-12 -0.6744674 0.423 0.393 1.248263e-08 CTL_MUT
## Sox4 4.212366e-12 3.4176111 0.141 0.085 1.263710e-08 CTL_MUT
## Cplx3 4.489294e-12 -1.0751364 0.209 0.010 1.346788e-08 CTL_MUT
## Gstt2 4.768632e-12 3.3614604 0.146 0.015 1.430590e-08 CTL_MUT
## Enpp1 4.795653e-12 -1.1137321 0.138 0.009 1.438696e-08 CTL_MUT
## Olfm1 4.903011e-12 1.1564425 0.415 0.391 1.470903e-08 CTL_MUT
## Ckap2 5.107220e-12 0.3560520 0.108 0.116 1.532166e-08 CTL_MUT
## Epha5 5.490320e-12 1.2332075 0.402 0.374 1.647096e-08 CTL_MUT
## Gpam 6.238398e-12 0.7782974 0.121 0.072 1.871519e-08 CTL_MUT
## Rhobtb1 6.502308e-12 -4.1334565 0.145 0.046 1.950692e-08 CTL_MUT
## Adcy7 6.671946e-12 -2.3249424 0.124 0.005 2.001584e-08 CTL_MUT
## Lrrtm4 7.715489e-12 -2.3429886 0.382 0.350 2.314647e-08 CTL_MUT
## Kcnq1 8.854139e-12 -3.0709718 0.101 0.007 2.656242e-08 CTL_MUT
## Ppp1r18 9.021283e-12 4.9981575 0.157 0.019 2.706385e-08 CTL_MUT
## Grap2 1.088905e-11 -1.0238071 0.115 0.001 3.266714e-08 CTL_MUT
## Gm42948 1.111640e-11 -1.5160984 0.111 0.043 3.334920e-08 CTL_MUT
## Serinc3 1.154703e-11 0.5217061 0.188 0.166 3.464109e-08 CTL_MUT
## Zmat4 1.223865e-11 0.5030786 0.285 0.268 3.671596e-08 CTL_MUT
## Gabrb1 1.397987e-11 -1.4768733 0.414 0.391 4.193960e-08 CTL_MUT
## Reep5 1.458669e-11 -12.2292065 0.337 0.357 4.376008e-08 CTL_MUT
## Ntn1 1.528024e-11 -1.0549467 0.103 0.024 4.584071e-08 CTL_MUT
## Parp9 1.668205e-11 -1.9204933 0.164 0.010 5.004615e-08 CTL_MUT
## Nos1 1.670597e-11 1.4076903 0.147 0.039 5.011791e-08 CTL_MUT
## Cdk6 1.801309e-11 -1.1314307 0.106 0.055 5.403927e-08 CTL_MUT
## Trim34a 1.845137e-11 0.6355717 0.146 0.006 5.535411e-08 CTL_MUT
## 4930547E14Rik 1.976370e-11 -0.6939277 0.191 0.077 5.929111e-08 CTL_MUT
## Bmf 2.153650e-11 3.8455139 0.115 0.004 6.460951e-08 CTL_MUT
## Slc2a13 2.302367e-11 2.5023359 0.316 0.308 6.907100e-08 CTL_MUT
## Rps6ka5 2.503522e-11 5.7838227 0.190 0.139 7.510565e-08 CTL_MUT
## Plpp3 2.974911e-11 0.7128837 0.212 0.241 8.924734e-08 CTL_MUT
## Frmd4a 3.291113e-11 -2.7256345 0.406 0.385 9.873340e-08 CTL_MUT
## Ccnd1 3.393454e-11 -4.2160224 0.128 0.067 1.018036e-07 CTL_MUT
## Ctnna3 3.460036e-11 -0.4515637 0.289 0.295 1.038011e-07 CTL_MUT
## Gm37885 3.500076e-11 -5.6280192 0.120 0.011 1.050023e-07 CTL_MUT
## Pllp 3.730769e-11 -1.5952936 0.129 0.097 1.119231e-07 CTL_MUT
## Rhog 3.879872e-11 -0.9846039 0.113 0.085 1.163962e-07 CTL_MUT
## Naprt 4.112160e-11 -6.0345867 0.170 0.010 1.233648e-07 CTL_MUT
## Tpt1 4.225773e-11 -0.9771351 0.371 0.385 1.267732e-07 CTL_MUT
## Fxyd6 4.434690e-11 5.0703229 0.136 0.112 1.330407e-07 CTL_MUT
## Lims2 4.503651e-11 -2.4688273 0.115 0.055 1.351095e-07 CTL_MUT
## Tenm1 4.583753e-11 3.8584376 0.280 0.254 1.375126e-07 CTL_MUT
## Slc7a5 4.592263e-11 -0.9327822 0.141 0.080 1.377679e-07 CTL_MUT
## Gm41414 4.673770e-11 -0.5029390 0.119 0.015 1.402131e-07 CTL_MUT
## Nr2e1 4.976921e-11 -0.8884091 0.133 0.022 1.493076e-07 CTL_MUT
## Dlc1 5.520316e-11 1.1708406 0.195 0.191 1.656095e-07 CTL_MUT
## A330015K06Rik 6.317828e-11 4.6110275 0.202 0.161 1.895348e-07 CTL_MUT
## Gm3764 6.344461e-11 3.2158011 0.260 0.255 1.903338e-07 CTL_MUT
## Lmo2 6.470669e-11 -3.7042982 0.174 0.022 1.941201e-07 CTL_MUT
## Cdc14a 7.066937e-11 -2.6632120 0.145 0.028 2.120081e-07 CTL_MUT
## Hs6st3 7.075238e-11 -2.5921165 0.326 0.291 2.122571e-07 CTL_MUT
## Clstn2 7.131262e-11 -1.1682847 0.400 0.368 2.139379e-07 CTL_MUT
## Mrc2 7.197506e-11 -0.8156572 0.194 0.008 2.159252e-07 CTL_MUT
## Pcdhgb6 7.562822e-11 3.8736350 0.257 0.004 2.268847e-07 CTL_MUT
## 4930555F03Rik 7.667372e-11 -1.4849383 0.122 0.012 2.300212e-07 CTL_MUT
## Garnl3 8.115047e-11 1.5053764 0.183 0.167 2.434514e-07 CTL_MUT
## E330013P04Rik 8.638337e-11 -5.4966104 0.157 0.008 2.591501e-07 CTL_MUT
## Resp18 9.029538e-11 -5.4026911 0.147 0.107 2.708861e-07 CTL_MUT
## Mcm3 1.102761e-10 -3.0662416 0.184 0.005 3.308284e-07 CTL_MUT
## Sox11 1.172214e-10 -0.3671100 0.100 0.079 3.516641e-07 CTL_MUT
## Neurod1 1.263101e-10 -1.2651489 0.136 0.057 3.789304e-07 CTL_MUT
## Lbh 1.263922e-10 -2.0372063 0.163 0.056 3.791765e-07 CTL_MUT
## Phldb1 1.274820e-10 6.0377282 0.124 0.130 3.824461e-07 CTL_MUT
## Gm31374 1.322481e-10 -0.6531332 0.108 0.002 3.967443e-07 CTL_MUT
## Atp1b3 1.329458e-10 -0.6608044 0.202 0.201 3.988374e-07 CTL_MUT
## Chst9 1.574049e-10 -9.7928070 0.149 0.077 4.722148e-07 CTL_MUT
## 6530411M01Rik 1.610578e-10 0.7537460 0.133 0.004 4.831735e-07 CTL_MUT
## Ppara 1.794230e-10 4.5590319 0.149 0.017 5.382689e-07 CTL_MUT
## Rcan1 1.802438e-10 -7.4886978 0.167 0.110 5.407315e-07 CTL_MUT
## Plxna4os3 1.812604e-10 0.9449266 0.157 0.054 5.437813e-07 CTL_MUT
## Nrg2 1.837057e-10 -0.5261261 0.229 0.204 5.511172e-07 CTL_MUT
## Calb1 2.002932e-10 -0.6366414 0.209 0.145 6.008796e-07 CTL_MUT
## Phlda3 2.157453e-10 4.4206912 0.135 0.112 6.472358e-07 CTL_MUT
## Phactr1 2.210036e-10 -0.7947793 0.412 0.381 6.630108e-07 CTL_MUT
## Sorbs1 2.386416e-10 -7.2753113 0.362 0.374 7.159249e-07 CTL_MUT
## Elmsan1 3.899453e-10 -5.7280703 0.182 0.089 1.169836e-06 CTL_MUT
## Has2os 4.118784e-10 -2.9868074 0.130 0.005 1.235635e-06 CTL_MUT
## Gm13187 4.324213e-10 -1.6839387 0.191 0.025 1.297264e-06 CTL_MUT
## Nat8f1 4.356416e-10 10.2850411 0.150 0.067 1.306925e-06 CTL_MUT
## Wfdc18 4.403578e-10 -1.5596618 0.117 0.020 1.321073e-06 CTL_MUT
## Ahi1 4.899241e-10 -0.4639240 0.413 0.403 1.469772e-06 CTL_MUT
## Gnb4 4.987564e-10 -4.0193706 0.156 0.089 1.496269e-06 CTL_MUT
## Gm15398 5.038570e-10 1.9783876 0.156 0.111 1.511571e-06 CTL_MUT
## Socs3 5.770622e-10 6.8298491 0.176 0.011 1.731187e-06 CTL_MUT
## Tcf7l2 5.899064e-10 2.7253077 0.136 0.081 1.769719e-06 CTL_MUT
## Ly6e 6.628687e-10 4.2280653 0.300 0.261 1.988606e-06 CTL_MUT
## Ccbe1 6.752139e-10 -2.1113586 0.167 0.083 2.025642e-06 CTL_MUT
## Fbxl7 6.986134e-10 -4.1451719 0.160 0.076 2.095840e-06 CTL_MUT
## Ebi3 7.282876e-10 -11.1744560 0.129 0.006 2.184863e-06 CTL_MUT
## Mxra8 7.303678e-10 -1.9542048 0.152 0.005 2.191103e-06 CTL_MUT
## Tlcd1 7.543772e-10 0.8174791 0.114 0.034 2.263132e-06 CTL_MUT
## Tnfrsf11a 7.775863e-10 -1.5851572 0.150 0.020 2.332759e-06 CTL_MUT
## Nfkb1 7.980067e-10 -1.6007624 0.168 0.158 2.394020e-06 CTL_MUT
## Gm30373 8.675092e-10 -0.7331936 0.102 0.003 2.602528e-06 CTL_MUT
## Notch3 8.870652e-10 0.9769493 0.118 0.017 2.661196e-06 CTL_MUT
## Tubb2b 9.049501e-10 -4.7148047 0.190 0.180 2.714850e-06 CTL_MUT
## Pdgfb 9.233985e-10 -0.2961574 0.115 0.062 2.770196e-06 CTL_MUT
## D730045A05Rik 9.965060e-10 -3.7398196 0.130 0.002 2.989518e-06 CTL_MUT
## Hist1h1b 1.016198e-09 3.4893919 0.165 0.110 3.048593e-06 CTL_MUT
## Cacna1e 1.018078e-09 -0.3271285 0.412 0.381 3.054234e-06 CTL_MUT
## Dsp 1.037025e-09 -1.5976740 0.163 0.052 3.111075e-06 CTL_MUT
## Pcsk5 1.080993e-09 -0.5644678 0.189 0.144 3.242980e-06 CTL_MUT
## Pmaip1 1.084351e-09 -2.8940271 0.124 0.005 3.253053e-06 CTL_MUT
## Adamts17 1.092659e-09 2.5198844 0.201 0.150 3.277976e-06 CTL_MUT
## A630012P03Rik 1.189367e-09 -0.3968488 0.117 0.002 3.568102e-06 CTL_MUT
## Il17rd 1.308647e-09 -7.0842378 0.183 0.013 3.925940e-06 CTL_MUT
## Tes 1.429073e-09 2.2105203 0.151 0.015 4.287218e-06 CTL_MUT
## Gm50103 1.467492e-09 -3.2495949 0.170 0.002 4.402476e-06 CTL_MUT
## 6030407O03Rik 1.592116e-09 -4.3898335 0.168 0.008 4.776349e-06 CTL_MUT
## Emx2 1.600264e-09 -5.7158695 0.148 0.037 4.800791e-06 CTL_MUT
## Kctd12b 1.770221e-09 -3.2557100 0.138 0.010 5.310662e-06 CTL_MUT
## Megf11 1.793611e-09 -4.6617042 0.125 0.049 5.380832e-06 CTL_MUT
## Pde4d 1.795288e-09 0.9269991 0.379 0.365 5.385864e-06 CTL_MUT
## Dpf3 1.841346e-09 -2.6285048 0.183 0.113 5.524037e-06 CTL_MUT
## Mtss2 1.868629e-09 0.9296747 0.176 0.125 5.605886e-06 CTL_MUT
## Map7 1.898256e-09 -2.3696758 0.275 0.278 5.694767e-06 CTL_MUT
## Pakap.1 1.941046e-09 -6.3304790 0.203 0.194 5.823139e-06 CTL_MUT
## Tnnc1 1.946558e-09 -3.6233441 0.162 0.036 5.839674e-06 CTL_MUT
## Cadps2 2.023080e-09 -1.9639235 0.239 0.209 6.069239e-06 CTL_MUT
## Rhoc 2.099013e-09 -7.4978597 0.157 0.059 6.297040e-06 CTL_MUT
## Gm30382 2.195234e-09 1.3593192 0.169 0.096 6.585703e-06 CTL_MUT
## Dennd4a 2.202448e-09 -2.5631632 0.218 0.237 6.607345e-06 CTL_MUT
## Ighm 2.386040e-09 -5.4579160 0.177 0.027 7.158120e-06 CTL_MUT
## Aff1 2.404444e-09 -5.4093016 0.159 0.095 7.213333e-06 CTL_MUT
## Gli3 2.735299e-09 5.1084569 0.100 0.064 8.205898e-06 CTL_MUT
## Ablim1 2.914608e-09 -3.3976597 0.325 0.313 8.743825e-06 CTL_MUT
## Rab3c 3.640786e-09 3.0139095 0.274 0.247 1.092236e-05 CTL_MUT
## Penk 4.145906e-09 -0.3051636 0.186 0.032 1.243772e-05 CTL_MUT
## Agmo 4.389146e-09 -2.5315420 0.141 0.052 1.316744e-05 CTL_MUT
## Il10rb 4.572362e-09 3.9691608 0.124 0.017 1.371709e-05 CTL_MUT
## Pcdh17 4.643682e-09 -1.6886619 0.320 0.312 1.393105e-05 CTL_MUT
## Lhfpl3 5.074682e-09 1.2484071 0.127 0.134 1.522405e-05 CTL_MUT
## Dgkh 5.469928e-09 -0.5837557 0.332 0.337 1.640978e-05 CTL_MUT
## Ccn1 5.650975e-09 4.1476351 0.111 0.046 1.695292e-05 CTL_MUT
## Mmd2 6.626454e-09 -2.2612920 0.239 0.219 1.987936e-05 CTL_MUT
## Snrk 6.896990e-09 2.6018006 0.183 0.153 2.069097e-05 CTL_MUT
## Alcam 7.229961e-09 0.9044123 0.290 0.286 2.168988e-05 CTL_MUT
## Gm14964 7.326447e-09 10.5254644 0.153 0.016 2.197934e-05 CTL_MUT
## Myo10 7.350916e-09 1.6377516 0.154 0.114 2.205275e-05 CTL_MUT
## Epas1 7.883562e-09 2.7285226 0.151 0.131 2.365068e-05 CTL_MUT
## Tspo 8.449232e-09 -5.6211154 0.100 0.035 2.534769e-05 CTL_MUT
## Pip5k1b 8.784402e-09 -1.5095026 0.296 0.255 2.635321e-05 CTL_MUT
## 2610307P16Rik 9.305014e-09 0.3086334 0.125 0.016 2.791504e-05 CTL_MUT
## Gpx1 9.411145e-09 -3.4967237 0.185 0.123 2.823344e-05 CTL_MUT
## Mef2a 9.757588e-09 -10.1822415 0.283 0.268 2.927276e-05 CTL_MUT
## Dleu2 9.825695e-09 4.9682736 0.233 0.236 2.947709e-05 CTL_MUT
## Gm32828 1.021436e-08 -1.4755037 0.189 0.006 3.064309e-05 CTL_MUT
## Cdkn1a 1.022891e-08 -2.4088815 0.124 0.087 3.068674e-05 CTL_MUT
## Fermt2 1.028845e-08 1.6903033 0.297 0.298 3.086536e-05 CTL_MUT
## Cit 1.068130e-08 1.5866251 0.236 0.223 3.204390e-05 CTL_MUT
## Mir99ahg 1.113399e-08 0.3265975 0.342 0.366 3.340198e-05 CTL_MUT
## mt-Co3 1.150361e-08 -0.7193453 0.408 0.426 3.451084e-05 CTL_MUT
## 1700017B05Rik 1.202283e-08 3.9351076 0.158 0.021 3.606849e-05 CTL_MUT
## St6gal1 1.319964e-08 -5.5705602 0.158 0.094 3.959893e-05 CTL_MUT
## Gm26532 1.458061e-08 2.1488228 0.110 0.074 4.374182e-05 CTL_MUT
## Gm37459 1.473866e-08 -1.1067511 0.191 0.101 4.421597e-05 CTL_MUT
## B230217J21Rik 1.537944e-08 0.9204058 0.174 0.008 4.613831e-05 CTL_MUT
## Sat1 1.742215e-08 1.9374851 0.181 0.172 5.226644e-05 CTL_MUT
## Shisa6 1.752791e-08 0.6006051 0.318 0.259 5.258373e-05 CTL_MUT
## Fgf12 1.981038e-08 -0.3879606 0.388 0.372 5.943114e-05 CTL_MUT
## Man1a 2.173001e-08 -2.5082474 0.209 0.175 6.519004e-05 CTL_MUT
## Arr3 2.332038e-08 0.3311681 0.159 0.012 6.996114e-05 CTL_MUT
## Usp53 2.453636e-08 1.9694851 0.147 0.097 7.360909e-05 CTL_MUT
## Zic2 2.511226e-08 -5.8662206 0.159 0.011 7.533678e-05 CTL_MUT
## 9330117O12Rik 2.548325e-08 -2.3628048 0.103 0.006 7.644975e-05 CTL_MUT
## Scrg1 2.621886e-08 -2.1296754 0.137 0.099 7.865659e-05 CTL_MUT
## Esrrg 2.632973e-08 1.5925088 0.200 0.174 7.898919e-05 CTL_MUT
## Akap12 2.651827e-08 1.7149755 0.101 0.092 7.955482e-05 CTL_MUT
## Lima1 3.596376e-08 7.9234172 0.132 0.066 1.078913e-04 CTL_MUT
## Thsd7a 3.874023e-08 -7.6573552 0.255 0.224 1.162207e-04 CTL_MUT
## Gm21057 3.913010e-08 -2.9423483 0.157 0.003 1.173903e-04 CTL_MUT
## Tmem100 4.095582e-08 5.1863807 0.105 0.047 1.228674e-04 CTL_MUT
## AC149090.1 4.153522e-08 -1.1126515 0.410 0.394 1.246057e-04 CTL_MUT
## St5 4.435609e-08 -1.3779005 0.167 0.081 1.330683e-04 CTL_MUT
## Rsad2 4.438975e-08 -0.5911200 0.108 0.008 1.331693e-04 CTL_MUT
## Cd9 4.496738e-08 5.1499173 0.152 0.127 1.349021e-04 CTL_MUT
## Xylt1 5.002647e-08 -0.5851978 0.262 0.248 1.500794e-04 CTL_MUT
## Meg3 5.045522e-08 -8.0257673 0.423 0.392 1.513657e-04 CTL_MUT
## Plcl1 5.099471e-08 1.9782574 0.307 0.326 1.529841e-04 CTL_MUT
## Prkcd 5.255398e-08 0.6128087 0.111 0.014 1.576619e-04 CTL_MUT
## Nuf2 5.273200e-08 -2.0915697 0.174 0.005 1.581960e-04 CTL_MUT
## Actb 5.367506e-08 -0.8880717 0.353 0.367 1.610252e-04 CTL_MUT
## Cth 5.415941e-08 -3.1336890 0.140 0.005 1.624782e-04 CTL_MUT
## Il18 5.483395e-08 2.3945083 0.151 0.112 1.645018e-04 CTL_MUT
## Nts 5.751463e-08 3.2902451 0.124 0.005 1.725439e-04 CTL_MUT
## Gpr37 5.800019e-08 -1.9531547 0.114 0.085 1.740006e-04 CTL_MUT
## Grik3 5.992654e-08 0.8958394 0.155 0.120 1.797796e-04 CTL_MUT
## Epcam 6.372080e-08 -1.2930687 0.101 0.002 1.911624e-04 CTL_MUT
## Hist1h1c 6.579121e-08 -7.3950759 0.182 0.067 1.973736e-04 CTL_MUT
## Bcor 6.614889e-08 -3.3698069 0.178 0.105 1.984467e-04 CTL_MUT
## Shoc1 6.856896e-08 1.2094401 0.130 0.014 2.057069e-04 CTL_MUT
## Cdh4 7.747336e-08 0.3211565 0.175 0.081 2.324201e-04 CTL_MUT
## Pld1 9.490965e-08 -2.0216479 0.124 0.045 2.847290e-04 CTL_MUT
## H2afj 9.688577e-08 -1.3908675 0.351 0.364 2.906573e-04 CTL_MUT
## Cck 1.027235e-07 -2.6378267 0.359 0.347 3.081705e-04 CTL_MUT
## Ubb 1.043683e-07 -0.3970966 0.384 0.407 3.131049e-04 CTL_MUT
## Syngr2 1.094183e-07 -5.7242272 0.134 0.031 3.282548e-04 CTL_MUT
## Slc4a4 1.145980e-07 -3.9677678 0.321 0.335 3.437940e-04 CTL_MUT
## Mki67 1.157811e-07 1.8956807 0.195 0.008 3.473433e-04 CTL_MUT
## Gpr146 1.160187e-07 -1.0815844 0.165 0.039 3.480561e-04 CTL_MUT
## Kcnh7 1.161566e-07 -1.6505461 0.369 0.327 3.484699e-04 CTL_MUT
## Frmd5 1.165073e-07 2.6667905 0.319 0.342 3.495218e-04 CTL_MUT
## Rin2 1.173848e-07 2.5987943 0.144 0.085 3.521545e-04 CTL_MUT
## Gm16576 1.182506e-07 -1.5394484 0.171 0.006 3.547518e-04 CTL_MUT
## Frmd4b 1.220276e-07 3.5225432 0.279 0.274 3.660828e-04 CTL_MUT
## Dab2 1.309661e-07 2.0154693 0.153 0.017 3.928982e-04 CTL_MUT
## Spon1 1.377595e-07 -1.4079275 0.218 0.187 4.132784e-04 CTL_MUT
## Gsap 1.379491e-07 -12.0529361 0.145 0.039 4.138474e-04 CTL_MUT
## Slc1a3 1.441150e-07 0.9054015 0.232 0.257 4.323451e-04 CTL_MUT
## Gm11681 1.523244e-07 -0.4043426 0.157 0.005 4.569731e-04 CTL_MUT
## Nfkbie 1.595981e-07 -0.6820835 0.135 0.010 4.787942e-04 CTL_MUT
## Cast 1.615582e-07 -0.6846795 0.128 0.030 4.846746e-04 CTL_MUT
## Zc3hav1 1.727820e-07 -3.2921409 0.115 0.017 5.183459e-04 CTL_MUT
## Gm31718 1.845063e-07 -0.7947667 0.141 0.009 5.535188e-04 CTL_MUT
## Sirt2 1.853463e-07 -0.5803648 0.188 0.206 5.560388e-04 CTL_MUT
## Heyl 1.879644e-07 1.5569648 0.119 0.004 5.638932e-04 CTL_MUT
## Ifi30 2.068981e-07 0.3070099 0.135 0.015 6.206944e-04 CTL_MUT
## Sh3d21 2.166941e-07 -0.5995292 0.127 0.007 6.500824e-04 CTL_MUT
## Rab8b 2.299904e-07 -1.1203504 0.238 0.171 6.899713e-04 CTL_MUT
## Dscam 2.343607e-07 -1.3725947 0.367 0.348 7.030821e-04 CTL_MUT
## Gm43221 2.473238e-07 -1.6947623 0.183 0.005 7.419714e-04 CTL_MUT
## Itga5 2.575896e-07 -2.1697104 0.119 0.018 7.727689e-04 CTL_MUT
## Fabp5 2.713122e-07 -5.2051404 0.330 0.357 8.139367e-04 CTL_MUT
## Tmem37 2.750144e-07 -3.3229729 0.133 0.008 8.250432e-04 CTL_MUT
## Mt2 2.759460e-07 0.5592530 0.257 0.231 8.278379e-04 CTL_MUT
## Cdk11b 2.901282e-07 -12.1875755 0.224 0.197 8.703845e-04 CTL_MUT
## Pde10a 2.939491e-07 -1.8066776 0.365 0.354 8.818474e-04 CTL_MUT
## Tma16 3.274283e-07 1.2754150 0.183 0.046 9.822849e-04 CTL_MUT
## Eva1b 3.406902e-07 -0.3326209 0.108 0.022 1.022071e-03 CTL_MUT
## Dock6 3.487844e-07 -3.7354641 0.115 0.023 1.046353e-03 CTL_MUT
## Tgfb1 3.702790e-07 2.4985503 0.102 0.038 1.110837e-03 CTL_MUT
## Steap3 4.136081e-07 -1.5057528 0.161 0.011 1.240824e-03 CTL_MUT
## Gch1 4.373528e-07 -1.8218351 0.110 0.026 1.312058e-03 CTL_MUT
## Shisa9 4.683362e-07 -5.0606447 0.311 0.297 1.405009e-03 CTL_MUT
## Tmem108 4.787722e-07 0.3016142 0.330 0.314 1.436317e-03 CTL_MUT
## Ifnar2 4.876677e-07 1.3304644 0.173 0.106 1.463003e-03 CTL_MUT
## Ccnd3 5.156883e-07 -2.0750094 0.145 0.078 1.547065e-03 CTL_MUT
## Ccnl1 5.217081e-07 -5.4371930 0.236 0.214 1.565124e-03 CTL_MUT
## Fibin 5.292174e-07 2.1359382 0.117 0.003 1.587652e-03 CTL_MUT
## Brinp1 5.319453e-07 -1.3154415 0.411 0.383 1.595836e-03 CTL_MUT
## Mill2 5.376485e-07 1.4472182 0.110 0.015 1.612945e-03 CTL_MUT
## Gm38562 5.411832e-07 4.1295636 0.191 0.013 1.623549e-03 CTL_MUT
## Rora 5.883373e-07 -0.4429375 0.341 0.337 1.765012e-03 CTL_MUT
## Fgfr1 6.492459e-07 -7.1980784 0.185 0.127 1.947738e-03 CTL_MUT
## Mob3b 6.647728e-07 -2.5265477 0.123 0.044 1.994318e-03 CTL_MUT
## Ptprm 6.990505e-07 -0.3557664 0.176 0.181 2.097152e-03 CTL_MUT
## Fnbp1 7.321154e-07 -1.5167670 0.271 0.290 2.196346e-03 CTL_MUT
## Sncaip 7.900389e-07 2.7952132 0.164 0.050 2.370117e-03 CTL_MUT
## Acsbg1 7.913595e-07 2.7041093 0.119 0.092 2.374079e-03 CTL_MUT
## Scel 8.256711e-07 1.1704165 0.168 0.006 2.477013e-03 CTL_MUT
## Bvht 8.455771e-07 -2.3209603 0.116 0.006 2.536731e-03 CTL_MUT
## Kcnk13 8.487941e-07 -8.3432368 0.139 0.049 2.546382e-03 CTL_MUT
## Chrnb1 8.613461e-07 -0.9633561 0.120 0.003 2.584038e-03 CTL_MUT
## Phlpp1 8.807393e-07 -1.5359438 0.274 0.300 2.642218e-03 CTL_MUT
## Nxn 8.839199e-07 0.9542187 0.130 0.068 2.651760e-03 CTL_MUT
## Gm5086 9.449765e-07 -2.1157765 0.106 0.008 2.834930e-03 CTL_MUT
## Stk32b 9.536195e-07 0.2704626 0.144 0.007 2.860858e-03 CTL_MUT
## Hist1h2bc 9.643152e-07 0.3161777 0.187 0.166 2.892946e-03 CTL_MUT
## Chrm3 1.009014e-06 -1.9877747 0.339 0.288 3.027043e-03 CTL_MUT
## Elk3 1.024711e-06 0.3525212 0.151 0.080 3.074132e-03 CTL_MUT
## Gm45321 1.025056e-06 -1.4539508 0.126 0.008 3.075168e-03 CTL_MUT
## Emp2 1.086119e-06 1.4171581 0.145 0.042 3.258357e-03 CTL_MUT
## Il13ra1 1.093153e-06 -0.9061577 0.121 0.015 3.279458e-03 CTL_MUT
## BC028528 1.124798e-06 -11.6151533 0.126 0.012 3.374394e-03 CTL_MUT
## Hs3st4 1.142838e-06 -4.6007264 0.233 0.201 3.428514e-03 CTL_MUT
## Pou3f1 1.206678e-06 -2.0005521 0.182 0.129 3.620033e-03 CTL_MUT
## Dennd3 1.248785e-06 -3.9135069 0.116 0.028 3.746356e-03 CTL_MUT
## Kitl 1.322036e-06 -3.9958050 0.148 0.103 3.966107e-03 CTL_MUT
## Kndc1 1.498370e-06 -5.0849932 0.142 0.109 4.495109e-03 CTL_MUT
## Atg4a 1.652907e-06 5.3580023 0.197 0.116 4.958720e-03 CTL_MUT
## Col4a5 1.727516e-06 0.7399085 0.128 0.007 5.182548e-03 CTL_MUT
## Il1rapl1 1.760426e-06 -0.3934034 0.413 0.394 5.281277e-03 CTL_MUT
## Top2a 1.824929e-06 -1.6634194 0.129 0.076 5.474788e-03 CTL_MUT
## Sash1 2.042768e-06 -3.9542128 0.215 0.217 6.128303e-03 CTL_MUT
## Snx20 2.202374e-06 1.3964323 0.104 0.013 6.607121e-03 CTL_MUT
## Tspan7 2.289845e-06 0.7036331 0.393 0.400 6.869535e-03 CTL_MUT
## Fhod1 2.539919e-06 1.4089125 0.169 0.010 7.619758e-03 CTL_MUT
## Rcan2 3.054668e-06 0.7719047 0.215 0.224 9.164003e-03 CTL_MUT
## Akap13 3.310008e-06 -9.1132910 0.201 0.165 9.930023e-03 CTL_MUT
## Cflar 3.362425e-06 -4.1752654 0.113 0.054 1.008727e-02 CTL_MUT
## Nedd9 3.430599e-06 -0.9781511 0.155 0.069 1.029180e-02 CTL_MUT
## Esr1 4.124499e-06 -1.2894241 0.116 0.011 1.237350e-02 CTL_MUT
## Ythdc1 4.146101e-06 -15.4713863 0.300 0.262 1.243830e-02 CTL_MUT
## Samd4 4.338424e-06 -9.0578711 0.191 0.165 1.301527e-02 CTL_MUT
## Kank3 4.954429e-06 7.3402392 0.128 0.029 1.486329e-02 CTL_MUT
## Srgap2 5.438055e-06 1.1579569 0.296 0.279 1.631417e-02 CTL_MUT
## St8sia4 5.613160e-06 -5.4081853 0.155 0.038 1.683948e-02 CTL_MUT
## Fgf1 5.758806e-06 -3.7062358 0.151 0.086 1.727642e-02 CTL_MUT
## Iigp1 7.092097e-06 -1.3060099 0.154 0.005 2.127629e-02 CTL_MUT
## Farp1 7.155112e-06 -3.7849822 0.257 0.258 2.146534e-02 CTL_MUT
## Timp3 7.188844e-06 -1.1646331 0.211 0.176 2.156653e-02 CTL_MUT
## Palmd 8.112152e-06 -3.7128638 0.146 0.102 2.433646e-02 CTL_MUT
## Aspn 8.270261e-06 2.5885069 0.109 0.007 2.481078e-02 CTL_MUT
## Car10 8.766999e-06 -2.8090816 0.319 0.276 2.630100e-02 CTL_MUT
## Gm32509 8.973714e-06 3.3082919 0.213 0.158 2.692114e-02 CTL_MUT
## Ckb 1.005976e-05 0.7118475 0.374 0.397 3.017929e-02 CTL_MUT
## Prelid2 1.017861e-05 -1.4016604 0.164 0.003 3.053584e-02 CTL_MUT
## Tcf7 1.046673e-05 -0.3788638 0.132 0.007 3.140020e-02 CTL_MUT
## Loxl1 1.179834e-05 -1.7262367 0.149 0.005 3.539503e-02 CTL_MUT
## Gulp1 1.199632e-05 -5.9507551 0.133 0.025 3.598895e-02 CTL_MUT
## Kcnq5 1.402112e-05 1.8201864 0.348 0.306 4.206337e-02 CTL_MUT
## Htra1 1.424134e-05 1.0864109 0.173 0.191 4.272401e-02 CTL_MUT
## Gm38287 1.673327e-05 -4.6422630 0.132 0.003 5.019982e-02 CTL_MUT
## Pstpip2 1.700703e-05 -0.2912061 0.108 0.062 5.102110e-02 CTL_MUT
## H2afv 1.752496e-05 6.7298837 0.186 0.123 5.257487e-02 CTL_MUT
## Cntnap5c 1.781261e-05 -6.2438124 0.161 0.102 5.343782e-02 CTL_MUT
## Crh 1.930238e-05 0.2837782 0.131 0.009 5.790713e-02 CTL_MUT
## Tgif1 1.992518e-05 -0.4750771 0.111 0.010 5.977553e-02 CTL_MUT
## Sh3d19 2.232216e-05 12.7031072 0.184 0.168 6.696649e-02 CTL_MUT
## Cntnap2 2.312570e-05 -1.3229226 0.318 0.279 6.937710e-02 CTL_MUT
## Apobec1 2.324226e-05 -0.5068066 0.134 0.012 6.972679e-02 CTL_MUT
## Zbtb20 2.410919e-05 -1.8302588 0.420 0.401 7.232757e-02 CTL_MUT
## Slc12a2 2.440218e-05 -0.4925085 0.155 0.169 7.320654e-02 CTL_MUT
## Arl5b 2.473845e-05 1.5954806 0.184 0.130 7.421535e-02 CTL_MUT
## Sdk2 2.620105e-05 12.1877286 0.180 0.128 7.860316e-02 CTL_MUT
## Ecm1 2.654788e-05 9.8440134 0.149 0.020 7.964363e-02 CTL_MUT
## Cntn3 2.839857e-05 -2.0069367 0.272 0.256 8.519572e-02 CTL_MUT
## R3hdm1 2.909240e-05 -0.3092731 0.369 0.355 8.727720e-02 CTL_MUT
## Asic2 2.913390e-05 0.4370507 0.362 0.335 8.740169e-02 CTL_MUT
## Nrxn1 2.925960e-05 -1.3033543 0.416 0.397 8.777881e-02 CTL_MUT
## Igsf21 3.040609e-05 -1.4179725 0.152 0.092 9.121827e-02 CTL_MUT
## Ptn 3.128341e-05 -5.2637786 0.337 0.344 9.385022e-02 CTL_MUT
## Lsamp 3.353731e-05 -1.9354230 0.419 0.408 1.006119e-01 CTL_MUT
## Eps8l2 3.403742e-05 -2.9989142 0.161 0.007 1.021123e-01 CTL_MUT
## Nell1 3.410116e-05 3.3269875 0.228 0.186 1.023035e-01 CTL_MUT
## Ctsh 3.419634e-05 -6.9749832 0.103 0.036 1.025890e-01 CTL_MUT
## Dpp10 3.487943e-05 1.4748419 0.273 0.259 1.046383e-01 CTL_MUT
## Mctp1 3.840040e-05 0.3498489 0.310 0.300 1.152012e-01 CTL_MUT
## Jund 4.180660e-05 3.3972040 0.305 0.351 1.254198e-01 CTL_MUT
## Rab3il1 4.280230e-05 -0.5358062 0.183 0.010 1.284069e-01 CTL_MUT
## Cpne4 4.496612e-05 -7.7442584 0.221 0.182 1.348984e-01 CTL_MUT
## Pcdh9 4.599971e-05 3.2963660 0.353 0.379 1.379991e-01 CTL_MUT
## Gsta4 4.630740e-05 -5.1001833 0.149 0.064 1.389222e-01 CTL_MUT
## Vwc2 4.881772e-05 -1.5983191 0.117 0.019 1.464532e-01 CTL_MUT
## Gm38843 5.224917e-05 -0.5874868 0.140 0.004 1.567475e-01 CTL_MUT
## Map3k8 5.399177e-05 1.0679082 0.127 0.018 1.619753e-01 CTL_MUT
## Tenm4 5.412855e-05 2.4668066 0.350 0.301 1.623857e-01 CTL_MUT
## 1110008P14Rik 6.308304e-05 -2.4815544 0.354 0.364 1.892491e-01 CTL_MUT
## Zeb2 6.609468e-05 -6.6094517 0.412 0.391 1.982840e-01 CTL_MUT
## Serpini1 6.892368e-05 3.4827683 0.214 0.197 2.067710e-01 CTL_MUT
## C230035I16Rik 6.914870e-05 6.7163087 0.173 0.005 2.074461e-01 CTL_MUT
## Svil 7.315404e-05 4.2155722 0.160 0.071 2.194621e-01 CTL_MUT
## Myl6 7.424163e-05 -2.5446913 0.385 0.409 2.227249e-01 CTL_MUT
## Pik3r1 7.425116e-05 6.1428819 0.216 0.221 2.227535e-01 CTL_MUT
## Grm8 7.477529e-05 8.0891597 0.190 0.168 2.243259e-01 CTL_MUT
## Gm5089 7.598513e-05 1.6649218 0.138 0.039 2.279554e-01 CTL_MUT
## Rbpj 7.691578e-05 -5.9152037 0.200 0.144 2.307473e-01 CTL_MUT
## Cp 7.937979e-05 -1.6326630 0.101 0.026 2.381394e-01 CTL_MUT
## Gm16192 8.737001e-05 2.1086902 0.193 0.005 2.621100e-01 CTL_MUT
## Plk1 8.928393e-05 -0.9681208 0.115 0.059 2.678518e-01 CTL_MUT
## Fgfr2 9.033241e-05 -7.1562770 0.357 0.360 2.709972e-01 CTL_MUT
## Zfp385b 1.088485e-04 -6.6812281 0.296 0.259 3.265454e-01 CTL_MUT
## Ddah1 1.089366e-04 -7.1947538 0.206 0.174 3.268098e-01 CTL_MUT
## Slc24a1 1.094998e-04 -3.2388279 0.155 0.003 3.284993e-01 CTL_MUT
## Egfl7 1.128087e-04 -2.1902346 0.124 0.100 3.384261e-01 CTL_MUT
## Aass 1.184305e-04 -1.5130951 0.109 0.007 3.552915e-01 CTL_MUT
## Mapt 1.227197e-04 -0.5587573 0.375 0.387 3.681590e-01 CTL_MUT
## Sh2b2 1.286665e-04 -1.1572437 0.139 0.019 3.859996e-01 CTL_MUT
## Gm15283 1.314263e-04 2.5093993 0.150 0.066 3.942789e-01 CTL_MUT
## Slc9a3r2 1.325811e-04 1.3892237 0.112 0.078 3.977434e-01 CTL_MUT
## Mir100hg 1.326301e-04 -2.6043801 0.284 0.275 3.978903e-01 CTL_MUT
## Ttc9b 1.355109e-04 0.6044347 0.339 0.341 4.065328e-01 CTL_MUT
## Plcg2 1.451560e-04 5.3664544 0.133 0.023 4.354680e-01 CTL_MUT
## Snx24 1.512419e-04 -11.2793384 0.200 0.176 4.537257e-01 CTL_MUT
## Lrp5 1.679343e-04 -2.4043016 0.191 0.013 5.038030e-01 CTL_MUT
## Pkp2 1.695998e-04 1.1465698 0.169 0.077 5.087995e-01 CTL_MUT
## Abcc4 1.751093e-04 -2.1918188 0.128 0.071 5.253279e-01 CTL_MUT
## Arhgap25 1.853222e-04 -4.3219630 0.103 0.029 5.559667e-01 CTL_MUT
## Dscaml1 1.895697e-04 3.8989589 0.368 0.350 5.687090e-01 CTL_MUT
## Arhgap22 1.918030e-04 -1.1429332 0.100 0.049 5.754089e-01 CTL_MUT
## Khdrbs3 1.985209e-04 -0.3045125 0.370 0.323 5.955628e-01 CTL_MUT
## Atp2b4 2.043860e-04 2.9876195 0.158 0.126 6.131580e-01 CTL_MUT
## Marcksl1 2.047919e-04 -5.1535266 0.183 0.111 6.143758e-01 CTL_MUT
## Ifi27l2a 2.071035e-04 -2.0701192 0.160 0.003 6.213104e-01 CTL_MUT
## Ctnna1 2.089351e-04 -2.1615190 0.131 0.110 6.268052e-01 CTL_MUT
## Tmem141 2.120911e-04 -4.0117227 0.113 0.071 6.362733e-01 CTL_MUT
## Pcdh11x 2.220780e-04 -4.9085300 0.170 0.116 6.662339e-01 CTL_MUT
## Nfatc1 2.296328e-04 -2.0160813 0.148 0.020 6.888984e-01 CTL_MUT
## Fmnl3 2.326199e-04 -7.3457687 0.115 0.038 6.978596e-01 CTL_MUT
## Nfib 2.399153e-04 -0.5023804 0.386 0.396 7.197459e-01 CTL_MUT
## Aldh1a3 2.399736e-04 -1.9128438 0.163 0.003 7.199208e-01 CTL_MUT
## Zfhx3 2.475615e-04 -2.4066413 0.115 0.070 7.426846e-01 CTL_MUT
## Etv1 2.593076e-04 -2.8269638 0.203 0.194 7.779227e-01 CTL_MUT
## Lingo2 2.715522e-04 -2.6613394 0.393 0.359 8.146565e-01 CTL_MUT
## Abhd17b 2.780253e-04 -3.8079356 0.174 0.170 8.340758e-01 CTL_MUT
## Ecm2 2.812963e-04 -3.5277264 0.111 0.016 8.438888e-01 CTL_MUT
## D030055H07Rik 2.936706e-04 -0.4866213 0.110 0.004 8.810119e-01 CTL_MUT
## Gabrg3 2.958442e-04 -2.7524401 0.282 0.273 8.875325e-01 CTL_MUT
## Slfn2 3.289914e-04 0.6270835 0.132 0.010 9.869743e-01 CTL_MUT
## Gramd3 3.308717e-04 -0.4734856 0.121 0.071 9.926152e-01 CTL_MUT
## Col4a2 3.345566e-04 -9.1241514 0.160 0.109 1.000000e+00 CTL_MUT
## Smtn 3.435029e-04 -2.0122148 0.143 0.014 1.000000e+00 CTL_MUT
## Dlx1 3.437243e-04 -1.2368476 0.181 0.009 1.000000e+00 CTL_MUT
## Fam89a 3.480476e-04 -5.2221311 0.190 0.005 1.000000e+00 CTL_MUT
## Kif11 3.496667e-04 0.8457284 0.127 0.070 1.000000e+00 CTL_MUT
## Tmeff2 3.501024e-04 -0.4271809 0.278 0.290 1.000000e+00 CTL_MUT
## Il1rapl2 3.571879e-04 0.2680623 0.128 0.092 1.000000e+00 CTL_MUT
## A330048O09Rik 3.720352e-04 -2.8910880 0.146 0.009 1.000000e+00 CTL_MUT
## 4930544I03Rik 3.898238e-04 -3.4413758 0.156 0.008 1.000000e+00 CTL_MUT
## Slit1 4.114588e-04 -2.9560047 0.277 0.220 1.000000e+00 CTL_MUT
## Tnr 4.124820e-04 -1.9114087 0.344 0.321 1.000000e+00 CTL_MUT
## Cdh20 4.252515e-04 -1.2286388 0.166 0.164 1.000000e+00 CTL_MUT
## Klf12 4.460215e-04 -1.4886706 0.296 0.307 1.000000e+00 CTL_MUT
## Gm42047 4.652599e-04 -1.3203936 0.173 0.007 1.000000e+00 CTL_MUT
## Gm41505 4.655585e-04 -1.5814489 0.186 0.100 1.000000e+00 CTL_MUT
## Stab1 4.834929e-04 -0.9055718 0.101 0.013 1.000000e+00 CTL_MUT
## Gm2164 4.853260e-04 -4.4737495 0.168 0.102 1.000000e+00 CTL_MUT
## Bsg 4.856009e-04 1.5904229 0.230 0.235 1.000000e+00 CTL_MUT
## Lrp1b 4.856566e-04 1.1179261 0.413 0.399 1.000000e+00 CTL_MUT
## Etv6 5.092783e-04 -3.2558336 0.232 0.211 1.000000e+00 CTL_MUT
## Stxbp3 5.233485e-04 0.9404437 0.166 0.099 1.000000e+00 CTL_MUT
## Pcp4l1 5.337160e-04 0.4286919 0.114 0.067 1.000000e+00 CTL_MUT
## Cables1 5.740156e-04 -4.5765117 0.183 0.090 1.000000e+00 CTL_MUT
## Ptprz1 5.747420e-04 -0.7102404 0.247 0.260 1.000000e+00 CTL_MUT
## Rad51b 5.978713e-04 -2.2105658 0.130 0.018 1.000000e+00 CTL_MUT
## Tsc22d3 6.197084e-04 2.5606512 0.128 0.095 1.000000e+00 CTL_MUT
## Cox6a2 6.591250e-04 -1.5076491 0.176 0.023 1.000000e+00 CTL_MUT
## Sh2d6 6.609285e-04 -1.6759364 0.122 0.002 1.000000e+00 CTL_MUT
## Fzd4 6.662607e-04 0.7770885 0.116 0.023 1.000000e+00 CTL_MUT
## Ctnna2 6.753229e-04 0.5326858 0.409 0.402 1.000000e+00 CTL_MUT
## Mapkapk3 6.958649e-04 -2.7744375 0.146 0.009 1.000000e+00 CTL_MUT
## 2310001H17Rik 7.509612e-04 -0.3352539 0.139 0.005 1.000000e+00 CTL_MUT
## Daglb 8.743174e-04 -0.3403963 0.149 0.100 1.000000e+00 CTL_MUT
## Rffl 8.948829e-04 7.3590166 0.140 0.075 1.000000e+00 CTL_MUT
## Cdh18 9.267395e-04 1.8878900 0.158 0.138 1.000000e+00 CTL_MUT
## 5033421B08Rik 9.406917e-04 2.0269016 0.176 0.014 1.000000e+00 CTL_MUT
## Notch1 9.617709e-04 -0.3941414 0.133 0.052 1.000000e+00 CTL_MUT
## Plscr4 1.003126e-03 7.0322755 0.131 0.023 1.000000e+00 CTL_MUT
## Prr16 1.025410e-03 -1.5209056 0.184 0.114 1.000000e+00 CTL_MUT
## Nckap5 1.187335e-03 2.2427608 0.191 0.162 1.000000e+00 CTL_MUT
## Adra1a 1.198859e-03 4.1682836 0.158 0.069 1.000000e+00 CTL_MUT
## Relb 1.295984e-03 -2.9903623 0.131 0.034 1.000000e+00 CTL_MUT
## Prrx1 1.398466e-03 3.5770785 0.104 0.025 1.000000e+00 CTL_MUT
## Pln 1.421588e-03 -0.5042282 0.178 0.004 1.000000e+00 CTL_MUT
## March1 1.489389e-03 0.4373080 0.356 0.352 1.000000e+00 CTL_MUT
## Hist1h1d 1.523106e-03 0.5317384 0.162 0.007 1.000000e+00 CTL_MUT
## Grm3 1.524936e-03 0.5384307 0.257 0.272 1.000000e+00 CTL_MUT
## Rgma 1.572987e-03 -6.6412082 0.135 0.053 1.000000e+00 CTL_MUT
## Ctnnd2 1.598800e-03 -0.3754585 0.415 0.401 1.000000e+00 CTL_MUT
## Mast4 1.632981e-03 -1.5442153 0.365 0.380 1.000000e+00 CTL_MUT
## Elf1 1.670823e-03 12.2035245 0.126 0.069 1.000000e+00 CTL_MUT
## Sostdc1 1.682652e-03 -2.0352896 0.213 0.005 1.000000e+00 CTL_MUT
## Tnfrsf1a 1.865721e-03 2.2009392 0.131 0.012 1.000000e+00 CTL_MUT
## Zcchc24 1.888426e-03 12.7761322 0.127 0.076 1.000000e+00 CTL_MUT
## Pde3b 1.968975e-03 -3.6975260 0.137 0.096 1.000000e+00 CTL_MUT
## Pdzd2 1.980129e-03 -4.9867474 0.281 0.240 1.000000e+00 CTL_MUT
## Gm30094 2.008451e-03 -3.1266633 0.158 0.006 1.000000e+00 CTL_MUT
## Cpe 2.014308e-03 1.7444546 0.386 0.378 1.000000e+00 CTL_MUT
## Plekhg1 2.018851e-03 -3.1927793 0.162 0.144 1.000000e+00 CTL_MUT
## Galnt14 2.027953e-03 1.2330566 0.164 0.121 1.000000e+00 CTL_MUT
## Ptprk 2.079208e-03 -1.3162679 0.284 0.287 1.000000e+00 CTL_MUT
## Neat1 2.092557e-03 -3.1487531 0.188 0.153 1.000000e+00 CTL_MUT
## Tmtc2 2.171613e-03 2.8931399 0.216 0.221 1.000000e+00 CTL_MUT
## Gm2115 2.205824e-03 -6.3453987 0.187 0.054 1.000000e+00 CTL_MUT
## Ndst3 2.208019e-03 -1.5442921 0.181 0.135 1.000000e+00 CTL_MUT
## Creg1 2.252759e-03 -1.2143406 0.138 0.088 1.000000e+00 CTL_MUT
## Csmd3 2.281441e-03 -1.0382303 0.373 0.370 1.000000e+00 CTL_MUT
## Ifi35 2.329201e-03 -5.2317713 0.113 0.012 1.000000e+00 CTL_MUT
## Cyp4v3 2.339730e-03 -4.8745684 0.135 0.007 1.000000e+00 CTL_MUT
## Marcks 2.398047e-03 -4.0811242 0.263 0.263 1.000000e+00 CTL_MUT
## Adgrg1 2.426378e-03 -3.5111359 0.150 0.058 1.000000e+00 CTL_MUT
## Tmsb10 2.538754e-03 0.7089472 0.285 0.273 1.000000e+00 CTL_MUT
## Gm37876 2.630955e-03 -3.5300406 0.200 0.005 1.000000e+00 CTL_MUT
## Gng5 2.706265e-03 1.4668516 0.215 0.214 1.000000e+00 CTL_MUT
## Slc6a1 2.839787e-03 7.2720450 0.142 0.096 1.000000e+00 CTL_MUT
## Capg 2.858455e-03 -1.0470784 0.107 0.008 1.000000e+00 CTL_MUT
## Trim43c 2.982046e-03 -2.5293310 0.143 0.003 1.000000e+00 CTL_MUT
## Ldb2 3.140226e-03 0.8885120 0.231 0.199 1.000000e+00 CTL_MUT
## Sh3gl3 3.158224e-03 1.3515103 0.150 0.147 1.000000e+00 CTL_MUT
## Arid3a 3.160478e-03 -3.3619861 0.154 0.023 1.000000e+00 CTL_MUT
## Erbin 3.247901e-03 -0.3611103 0.148 0.161 1.000000e+00 CTL_MUT
## 4933413L06Rik 3.486330e-03 3.8559144 0.156 0.042 1.000000e+00 CTL_MUT
## Scamp2 3.589581e-03 -7.7003907 0.121 0.088 1.000000e+00 CTL_MUT
## Dct 3.786461e-03 -2.3173185 0.103 0.009 1.000000e+00 CTL_MUT
## Myo6 3.823219e-03 1.8257597 0.208 0.240 1.000000e+00 CTL_MUT
## 6530403H02Rik 3.824099e-03 6.4324017 0.155 0.057 1.000000e+00 CTL_MUT
## Ftl1 3.896150e-03 6.5716500 0.359 0.377 1.000000e+00 CTL_MUT
## Aspg 3.896656e-03 0.5126332 0.117 0.003 1.000000e+00 CTL_MUT
## 3222401L13Rik 3.967098e-03 5.9331047 0.159 0.017 1.000000e+00 CTL_MUT
## Plat 4.125140e-03 -0.9577122 0.120 0.070 1.000000e+00 CTL_MUT
## Ptpro 4.128358e-03 -0.4021180 0.194 0.126 1.000000e+00 CTL_MUT
## Ddx58 4.205512e-03 -0.3682815 0.175 0.010 1.000000e+00 CTL_MUT
## Gm44148 4.462113e-03 0.2992640 0.176 0.004 1.000000e+00 CTL_MUT
## 4921534H16Rik 4.533826e-03 -5.2590524 0.188 0.098 1.000000e+00 CTL_MUT
## Prc1 4.584096e-03 -0.9526820 0.167 0.013 1.000000e+00 CTL_MUT
## B430010I23Rik 4.628378e-03 2.9997500 0.161 0.030 1.000000e+00 CTL_MUT
## Gm13708 4.728351e-03 -0.5797238 0.132 0.005 1.000000e+00 CTL_MUT
## Fau 4.769739e-03 1.5066625 0.387 0.400 1.000000e+00 CTL_MUT
## Irak2 4.923429e-03 -2.4779357 0.134 0.103 1.000000e+00 CTL_MUT
## Gprc5c 5.417362e-03 -3.1429921 0.139 0.005 1.000000e+00 CTL_MUT
## Lrrk1 5.464679e-03 -0.4533054 0.137 0.019 1.000000e+00 CTL_MUT
## Spock1 5.739142e-03 -3.6464290 0.316 0.282 1.000000e+00 CTL_MUT
## Astn2 5.759783e-03 5.8050812 0.283 0.294 1.000000e+00 CTL_MUT
## Gm7967 5.783005e-03 -1.8209907 0.112 0.010 1.000000e+00 CTL_MUT
## Col11a1 5.797538e-03 4.1795913 0.176 0.030 1.000000e+00 CTL_MUT
## Gm29260 5.969288e-03 -1.1405394 0.111 0.006 1.000000e+00 CTL_MUT
## Npas4 6.080216e-03 0.2745921 0.200 0.170 1.000000e+00 CTL_MUT
## Eid3 6.278460e-03 0.8804675 0.144 0.003 1.000000e+00 CTL_MUT
## Nfkbia 6.367823e-03 1.5840075 0.146 0.110 1.000000e+00 CTL_MUT
## Pde5a 6.377930e-03 0.9823812 0.118 0.022 1.000000e+00 CTL_MUT
## Msi2 6.622564e-03 -3.1609709 0.288 0.302 1.000000e+00 CTL_MUT
## Plekho2 6.759099e-03 -4.8221969 0.126 0.034 1.000000e+00 CTL_MUT
## Kirrel2 7.365349e-03 0.3328612 0.182 0.008 1.000000e+00 CTL_MUT
## Hspb2 7.373495e-03 -2.3459780 0.116 0.005 1.000000e+00 CTL_MUT
## Pygm 8.130940e-03 7.0508925 0.151 0.022 1.000000e+00 CTL_MUT
## Nefm 8.188138e-03 -10.6578827 0.234 0.185 1.000000e+00 CTL_MUT
## Ehd4 8.193264e-03 -4.2072699 0.115 0.038 1.000000e+00 CTL_MUT
## Lrrtm3 8.269751e-03 -4.2083945 0.271 0.266 1.000000e+00 CTL_MUT
## Mfsd2a 8.614051e-03 3.5180394 0.139 0.052 1.000000e+00 CTL_MUT
## Lgals9 8.651357e-03 -3.4426888 0.101 0.021 1.000000e+00 CTL_MUT
## Rgs20 8.844406e-03 3.1666942 0.176 0.155 1.000000e+00 CTL_MUT
## Npc2 9.100788e-03 1.9850436 0.221 0.212 1.000000e+00 CTL_MUT
## Piezo1 9.332741e-03 -2.7667394 0.111 0.021 1.000000e+00 CTL_MUT
## Cntn6 9.345588e-03 -3.6032597 0.126 0.078 1.000000e+00 CTL_MUT
## Cd81 9.615946e-03 -9.4578525 0.334 0.357 1.000000e+00 CTL_MUT
## Gm29521 1.062990e-02 -2.0854084 0.140 0.004 1.000000e+00 CTL_MUT
## Dnah9 1.063229e-02 1.8598900 0.181 0.091 1.000000e+00 CTL_MUT
## Rab32 1.098215e-02 3.1043931 0.185 0.004 1.000000e+00 CTL_MUT
## Rpe65 1.175913e-02 -0.6361687 0.118 0.004 1.000000e+00 CTL_MUT
## Gm28981 1.196492e-02 -0.9691318 0.123 0.004 1.000000e+00 CTL_MUT
## C030005K06Rik 1.200251e-02 -1.1925537 0.108 0.009 1.000000e+00 CTL_MUT
## Gm15581 1.216703e-02 -1.0374602 0.189 0.006 1.000000e+00 CTL_MUT
## Zfp36 1.222679e-02 -2.1829927 0.104 0.020 1.000000e+00 CTL_MUT
## Eya1 1.239614e-02 -9.8114130 0.135 0.057 1.000000e+00 CTL_MUT
## Ttc28 1.248827e-02 -0.8346292 0.179 0.160 1.000000e+00 CTL_MUT
## Plscr1 1.260790e-02 0.7955335 0.115 0.004 1.000000e+00 CTL_MUT
## Prdx1 1.322890e-02 0.3995321 0.260 0.308 1.000000e+00 CTL_MUT
## Arhgap12 1.347304e-02 -0.9603120 0.182 0.148 1.000000e+00 CTL_MUT
## Gm6994 1.376439e-02 -4.1010117 0.164 0.053 1.000000e+00 CTL_MUT
## Ifi27 1.417071e-02 1.2505931 0.183 0.144 1.000000e+00 CTL_MUT
## Tmem163 1.521677e-02 -2.0333690 0.136 0.116 1.000000e+00 CTL_MUT
## Pacs2 1.526981e-02 5.7915097 0.138 0.123 1.000000e+00 CTL_MUT
## Sema5a 1.531615e-02 5.2061733 0.259 0.252 1.000000e+00 CTL_MUT
## Hif3a 1.546843e-02 -11.6165488 0.106 0.021 1.000000e+00 CTL_MUT
## Thbd 1.551698e-02 -1.9354058 0.102 0.008 1.000000e+00 CTL_MUT
## S1pr1 1.621981e-02 3.8261624 0.148 0.142 1.000000e+00 CTL_MUT
## Lgals3bp 1.734985e-02 10.1322447 0.133 0.021 1.000000e+00 CTL_MUT
## Plxdc2 1.738030e-02 -0.7105278 0.243 0.263 1.000000e+00 CTL_MUT
## Sgk1 1.751398e-02 -14.5004851 0.239 0.226 1.000000e+00 CTL_MUT
## Tox 1.767686e-02 -0.5849763 0.161 0.154 1.000000e+00 CTL_MUT
## Gnai2 1.778882e-02 1.2106509 0.256 0.251 1.000000e+00 CTL_MUT
## Pde1a 1.807383e-02 -6.0230608 0.338 0.299 1.000000e+00 CTL_MUT
## Plekha1 1.844028e-02 -3.6793411 0.184 0.186 1.000000e+00 CTL_MUT
## Pdzrn4 1.896354e-02 5.7287993 0.172 0.126 1.000000e+00 CTL_MUT
## Etl4 1.897003e-02 -0.6560782 0.319 0.291 1.000000e+00 CTL_MUT
## Mef2c 1.994729e-02 -0.7459492 0.396 0.390 1.000000e+00 CTL_MUT
## St6galnac3 2.057645e-02 -2.0940885 0.315 0.323 1.000000e+00 CTL_MUT
## Fam163a 2.126370e-02 -8.9500177 0.122 0.031 1.000000e+00 CTL_MUT
## Gm6209 2.131000e-02 -1.7291706 0.109 0.002 1.000000e+00 CTL_MUT
## Ccrl2 2.136580e-02 -1.7235468 0.108 0.023 1.000000e+00 CTL_MUT
## Sorcs1 2.235762e-02 -6.8183462 0.242 0.220 1.000000e+00 CTL_MUT
## Tubb6 2.248099e-02 -1.4744095 0.173 0.008 1.000000e+00 CTL_MUT
## Rgs4 2.280636e-02 -8.5203945 0.206 0.198 1.000000e+00 CTL_MUT
## Ptprd 2.288670e-02 -3.2814904 0.358 0.365 1.000000e+00 CTL_MUT
## Col9a3 2.340286e-02 2.1434384 0.132 0.022 1.000000e+00 CTL_MUT
## Fibcd1 2.403179e-02 2.8199152 0.148 0.066 1.000000e+00 CTL_MUT
## Sgcz 2.500342e-02 -0.8844890 0.257 0.237 1.000000e+00 CTL_MUT
## Uba7 2.558653e-02 -4.4913671 0.165 0.006 1.000000e+00 CTL_MUT
## Lipc 2.610983e-02 -2.4794386 0.153 0.003 1.000000e+00 CTL_MUT
## Slc39a8 2.614335e-02 -2.6830643 0.147 0.007 1.000000e+00 CTL_MUT
## Tmem176a 2.623849e-02 -3.0388426 0.113 0.060 1.000000e+00 CTL_MUT
## Slc16a10 2.704616e-02 -6.3845162 0.179 0.083 1.000000e+00 CTL_MUT
## Acss1 2.734892e-02 1.7236339 0.166 0.076 1.000000e+00 CTL_MUT
## Mical1 2.734957e-02 12.1945375 0.197 0.012 1.000000e+00 CTL_MUT
## Pcsk6 2.760543e-02 3.4111644 0.128 0.057 1.000000e+00 CTL_MUT
## Ptchd4 2.820677e-02 -6.3675315 0.225 0.211 1.000000e+00 CTL_MUT
## Apoe 2.822651e-02 -0.5195778 0.223 0.247 1.000000e+00 CTL_MUT
## Chsy3 2.879068e-02 -0.6226778 0.275 0.255 1.000000e+00 CTL_MUT
## Arhgef26 2.906833e-02 -4.9238717 0.131 0.073 1.000000e+00 CTL_MUT
## Tgif2 3.022633e-02 -4.3690908 0.145 0.006 1.000000e+00 CTL_MUT
## Lama3 3.023632e-02 -2.1548845 0.119 0.019 1.000000e+00 CTL_MUT
## Smoc2 3.037014e-02 -7.0612911 0.162 0.061 1.000000e+00 CTL_MUT
## Kcnh5 3.045848e-02 -2.1760348 0.180 0.114 1.000000e+00 CTL_MUT
## Mtss1 3.053814e-02 5.2486362 0.151 0.117 1.000000e+00 CTL_MUT
## Gmfg 3.078769e-02 -1.7172360 0.108 0.009 1.000000e+00 CTL_MUT
## Rnf13 3.177536e-02 3.8867896 0.176 0.192 1.000000e+00 CTL_MUT
## Filip1l 3.335017e-02 6.9499771 0.160 0.058 1.000000e+00 CTL_MUT
## Il4ra 3.363185e-02 -4.2450907 0.148 0.007 1.000000e+00 CTL_MUT
## Mgat4c 3.431511e-02 -2.6786268 0.197 0.185 1.000000e+00 CTL_MUT
## Retreg1 3.471662e-02 -2.8721579 0.198 0.175 1.000000e+00 CTL_MUT
## Gm13544 3.500725e-02 -1.5948275 0.157 0.004 1.000000e+00 CTL_MUT
## Cst3 3.554181e-02 2.2661798 0.197 0.213 1.000000e+00 CTL_MUT
## Sh3bgrl 3.571404e-02 -8.5220211 0.162 0.136 1.000000e+00 CTL_MUT
## Rnaset2b 3.617058e-02 6.6139730 0.190 0.021 1.000000e+00 CTL_MUT
## Sh3bp2 3.635550e-02 -1.1569915 0.124 0.014 1.000000e+00 CTL_MUT
## Clec3b 3.723629e-02 -1.2936486 0.149 0.003 1.000000e+00 CTL_MUT
## Tpx2 3.834443e-02 -2.0943749 0.166 0.045 1.000000e+00 CTL_MUT
## Tap1 3.880829e-02 -1.7273677 0.220 0.003 1.000000e+00 CTL_MUT
## Nrgn 3.933300e-02 -1.1079377 0.346 0.346 1.000000e+00 CTL_MUT
## Foxo1 4.024416e-02 -1.9157865 0.166 0.116 1.000000e+00 CTL_MUT
## Mgat4a 4.036895e-02 -2.7171163 0.177 0.126 1.000000e+00 CTL_MUT
## Pla2g4a 4.135348e-02 -5.4270790 0.145 0.021 1.000000e+00 CTL_MUT
## Hes1 4.155940e-02 -8.0559946 0.149 0.067 1.000000e+00 CTL_MUT
## Gstm7 4.381785e-02 -6.9949230 0.125 0.077 1.000000e+00 CTL_MUT
## Gm26713 4.542661e-02 0.3841418 0.130 0.004 1.000000e+00 CTL_MUT
## Gm45341 4.568952e-02 0.7836626 0.123 0.004 1.000000e+00 CTL_MUT
## Sall1 4.649736e-02 -4.7365414 0.138 0.021 1.000000e+00 CTL_MUT
## Stard13 4.694663e-02 -6.7146665 0.212 0.185 1.000000e+00 CTL_MUT
## C1qb 4.783027e-02 3.4860953 0.122 0.122 1.000000e+00 CTL_MUT
## Nmi 4.968826e-02 -1.0119994 0.182 0.012 1.000000e+00 CTL_MUT
## Plpp4 5.009123e-02 -1.6582126 0.127 0.031 1.000000e+00 CTL_MUT
## S100a1 5.035683e-02 -10.9555020 0.274 0.287 1.000000e+00 CTL_MUT
## Unc5d 5.180882e-02 -4.3008064 0.250 0.220 1.000000e+00 CTL_MUT
## Ltbp4 5.209220e-02 4.7730559 0.165 0.064 1.000000e+00 CTL_MUT
## Phka1 5.488096e-02 -3.6339494 0.113 0.087 1.000000e+00 CTL_MUT
## Myo1d 5.617117e-02 -8.9181173 0.150 0.128 1.000000e+00 CTL_MUT
## Adgrv1 5.672777e-02 7.1272560 0.143 0.024 1.000000e+00 CTL_MUT
## Trpc6 5.718920e-02 -1.4156895 0.167 0.132 1.000000e+00 CTL_MUT
## Foxp2 5.841804e-02 1.6865648 0.100 0.061 1.000000e+00 CTL_MUT
## Soga1 5.909554e-02 -0.6462651 0.168 0.076 1.000000e+00 CTL_MUT
## Gfra1 5.925416e-02 -9.4533684 0.163 0.098 1.000000e+00 CTL_MUT
## Tjp2 6.070014e-02 -12.3937667 0.169 0.096 1.000000e+00 CTL_MUT
## Ror1 6.128501e-02 -5.2949544 0.163 0.089 1.000000e+00 CTL_MUT
## Cav1 6.535062e-02 1.4517243 0.120 0.024 1.000000e+00 CTL_MUT
## Fhod3 6.597162e-02 6.3140953 0.202 0.160 1.000000e+00 CTL_MUT
## Ggt1 6.597450e-02 0.3988908 0.146 0.006 1.000000e+00 CTL_MUT
## Loxl3 6.599667e-02 -2.3641494 0.165 0.006 1.000000e+00 CTL_MUT
## Htr1f 6.736606e-02 -11.0774018 0.151 0.091 1.000000e+00 CTL_MUT
## Pitpnc1 6.853378e-02 -5.9007996 0.300 0.314 1.000000e+00 CTL_MUT
## Dbi 6.869233e-02 5.3643806 0.285 0.308 1.000000e+00 CTL_MUT
## Lmod1 6.930555e-02 -0.7578564 0.196 0.005 1.000000e+00 CTL_MUT
## Pgm5 6.996766e-02 1.2020658 0.139 0.013 1.000000e+00 CTL_MUT
## Grid2 7.135580e-02 -2.6177213 0.291 0.310 1.000000e+00 CTL_MUT
## Edil3 7.226964e-02 -3.6171377 0.254 0.269 1.000000e+00 CTL_MUT
## Unc5c 7.305461e-02 1.5513278 0.276 0.282 1.000000e+00 CTL_MUT
## Grrp1 7.743001e-02 -1.1449304 0.134 0.008 1.000000e+00 CTL_MUT
## Slc25a24 7.744543e-02 -0.5600465 0.125 0.004 1.000000e+00 CTL_MUT
## Glis3 7.774105e-02 1.7224875 0.220 0.193 1.000000e+00 CTL_MUT
## Plcb4 7.907986e-02 4.8642909 0.227 0.197 1.000000e+00 CTL_MUT
## Fxyd7 8.015694e-02 -4.9414442 0.260 0.254 1.000000e+00 CTL_MUT
## Pde1c 8.232029e-02 1.7798632 0.140 0.045 1.000000e+00 CTL_MUT
## Prxl2a 8.530721e-02 -6.0300608 0.244 0.228 1.000000e+00 CTL_MUT
## Chrm2 8.548745e-02 1.1515451 0.109 0.059 1.000000e+00 CTL_MUT
## Gm17750 8.710923e-02 6.8792557 0.142 0.047 1.000000e+00 CTL_MUT
## Nt5dc2 8.805964e-02 -9.3190758 0.187 0.063 1.000000e+00 CTL_MUT
## A830018L16Rik 8.909899e-02 -3.1978099 0.266 0.238 1.000000e+00 CTL_MUT
## Camk2n1 9.061585e-02 -0.2558351 0.391 0.408 1.000000e+00 CTL_MUT
## Fmo1 9.131055e-02 -0.6927799 0.159 0.009 1.000000e+00 CTL_MUT
## Mt3 9.235000e-02 3.1920667 0.348 0.355 1.000000e+00 CTL_MUT
## Synpr 9.268175e-02 -4.8564958 0.245 0.242 1.000000e+00 CTL_MUT
## Aldoc 9.554036e-02 -2.9431305 0.308 0.343 1.000000e+00 CTL_MUT
## Pcp4 9.897316e-02 1.4245182 0.338 0.341 1.000000e+00 CTL_MUT
## Cobll1 1.002396e-01 6.2202669 0.138 0.075 1.000000e+00 CTL_MUT
## 2610035D17Rik 1.015262e-01 7.8457873 0.232 0.218 1.000000e+00 CTL_MUT
## Rnase4 1.029585e-01 -0.9231018 0.137 0.011 1.000000e+00 CTL_MUT
## C4b 1.047768e-01 -0.5231942 0.145 0.030 1.000000e+00 CTL_MUT
## Malat1 1.062559e-01 -1.5129793 0.452 0.436 1.000000e+00 CTL_MUT
## Adarb2 1.064655e-01 0.8959013 0.251 0.239 1.000000e+00 CTL_MUT
## Slc1a2 1.074926e-01 -2.1398391 0.245 0.260 1.000000e+00 CTL_MUT
## St3gal6 1.084619e-01 -6.7919552 0.120 0.074 1.000000e+00 CTL_MUT
## Id2 1.092119e-01 -5.1525808 0.181 0.165 1.000000e+00 CTL_MUT
## 2810407A14Rik 1.099464e-01 -0.4233238 0.128 0.004 1.000000e+00 CTL_MUT
## Tyrobp 1.123359e-01 -1.0166192 0.126 0.116 1.000000e+00 CTL_MUT
## Nap1l5 1.156757e-01 -2.4266970 0.268 0.284 1.000000e+00 CTL_MUT
## Rpl18a 1.202391e-01 2.1063267 0.386 0.391 1.000000e+00 CTL_MUT
## 9330158H04Rik 1.219818e-01 1.0873396 0.136 0.006 1.000000e+00 CTL_MUT
## Gpcpd1 1.258460e-01 -2.7460089 0.212 0.205 1.000000e+00 CTL_MUT
## Fignl2 1.311971e-01 -1.9366236 0.115 0.003 1.000000e+00 CTL_MUT
## Gal3st4 1.332984e-01 -0.9694548 0.158 0.008 1.000000e+00 CTL_MUT
## Fas 1.339540e-01 -0.4692949 0.120 0.016 1.000000e+00 CTL_MUT
## Tnfaip8 1.348969e-01 -1.8151361 0.128 0.029 1.000000e+00 CTL_MUT
## Pex5l 1.379203e-01 -1.5176125 0.339 0.321 1.000000e+00 CTL_MUT
## Gltp 1.387092e-01 -1.5534130 0.125 0.064 1.000000e+00 CTL_MUT
## Ankrd44 1.391275e-01 0.7909421 0.159 0.109 1.000000e+00 CTL_MUT
## Bmp7 1.478315e-01 -1.4139390 0.122 0.008 1.000000e+00 CTL_MUT
## Rorb 1.501436e-01 -0.3922295 0.185 0.166 1.000000e+00 CTL_MUT
## Galntl6 1.544360e-01 -0.4955047 0.221 0.194 1.000000e+00 CTL_MUT
## Snhg11 1.552977e-01 -0.6928029 0.407 0.372 1.000000e+00 CTL_MUT
## Sh3bp4 1.568822e-01 -1.6769992 0.126 0.040 1.000000e+00 CTL_MUT
## Zfpm2 1.600650e-01 1.7148235 0.295 0.321 1.000000e+00 CTL_MUT
## Clu 1.602568e-01 -1.0991842 0.270 0.275 1.000000e+00 CTL_MUT
## Gm39185 1.604577e-01 -1.1988086 0.128 0.034 1.000000e+00 CTL_MUT
## Slc24a2 1.610967e-01 -0.6085526 0.407 0.401 1.000000e+00 CTL_MUT
## Efna5 1.619234e-01 -1.2650329 0.235 0.199 1.000000e+00 CTL_MUT
## Itih3 1.626264e-01 -5.6779871 0.114 0.044 1.000000e+00 CTL_MUT
## Rplp0 1.638941e-01 4.8140556 0.355 0.385 1.000000e+00 CTL_MUT
## Luzp2 1.664241e-01 -0.5606310 0.235 0.235 1.000000e+00 CTL_MUT
## Maml2 1.677352e-01 1.7810017 0.322 0.333 1.000000e+00 CTL_MUT
## Spock2 1.693415e-01 0.4417635 0.315 0.312 1.000000e+00 CTL_MUT
## Gng12 1.713285e-01 9.4754644 0.201 0.186 1.000000e+00 CTL_MUT
## Gpx3 1.764731e-01 -1.3028372 0.166 0.003 1.000000e+00 CTL_MUT
## Cnksr3 1.796294e-01 1.9227955 0.146 0.045 1.000000e+00 CTL_MUT
## Fyn 1.836386e-01 -0.4161174 0.275 0.276 1.000000e+00 CTL_MUT
## Tmem40 1.855785e-01 0.9381878 0.148 0.004 1.000000e+00 CTL_MUT
## D030068K23Rik 1.864133e-01 -4.6282403 0.126 0.030 1.000000e+00 CTL_MUT
## Spsb4 1.885915e-01 -2.5475262 0.154 0.007 1.000000e+00 CTL_MUT
## Sema4d 1.947732e-01 -3.7361349 0.212 0.209 1.000000e+00 CTL_MUT
## Cd52 1.985762e-01 -0.9363699 0.109 0.020 1.000000e+00 CTL_MUT
## Dock5 1.993860e-01 -5.1669697 0.106 0.034 1.000000e+00 CTL_MUT
## Serpine2 2.002585e-01 0.2525166 0.178 0.172 1.000000e+00 CTL_MUT
## Bach1 2.011650e-01 -0.3638730 0.133 0.067 1.000000e+00 CTL_MUT
## Gpr156 2.097548e-01 -1.5199077 0.126 0.008 1.000000e+00 CTL_MUT
## Col5a3 2.136069e-01 -0.5804536 0.177 0.004 1.000000e+00 CTL_MUT
## Lrrc4c 2.142569e-01 -0.2689381 0.333 0.337 1.000000e+00 CTL_MUT
## Pip4k2a 2.197724e-01 -1.3999926 0.233 0.231 1.000000e+00 CTL_MUT
## Rnd2 2.200324e-01 0.4997760 0.133 0.062 1.000000e+00 CTL_MUT
## C1qa 2.210160e-01 0.7016771 0.120 0.118 1.000000e+00 CTL_MUT
## Col27a1 2.232070e-01 -1.7556630 0.142 0.015 1.000000e+00 CTL_MUT
## Pdzrn3 2.240327e-01 -3.2397103 0.226 0.204 1.000000e+00 CTL_MUT
## Als2cl 2.288426e-01 -4.8087803 0.129 0.006 1.000000e+00 CTL_MUT
## Ubc 2.299670e-01 -1.7041785 0.362 0.390 1.000000e+00 CTL_MUT
## Rnaset2a 2.324963e-01 -6.5800693 0.161 0.025 1.000000e+00 CTL_MUT
## Phldb2 2.340484e-01 0.6450467 0.126 0.029 1.000000e+00 CTL_MUT
## Gm34567 2.355870e-01 -2.2442297 0.149 0.025 1.000000e+00 CTL_MUT
## Cux2 2.381799e-01 -0.6048343 0.177 0.110 1.000000e+00 CTL_MUT
## Matn4 2.391495e-01 -3.2816580 0.108 0.036 1.000000e+00 CTL_MUT
## Lpp 2.473520e-01 8.8443520 0.217 0.173 1.000000e+00 CTL_MUT
## Arhgap24 2.481737e-01 -1.9010905 0.140 0.046 1.000000e+00 CTL_MUT
## Kazn 2.502239e-01 3.5368054 0.139 0.097 1.000000e+00 CTL_MUT
## Rgs6 2.555674e-01 0.9773745 0.285 0.272 1.000000e+00 CTL_MUT
## Lpar3 2.566523e-01 2.2742544 0.131 0.004 1.000000e+00 CTL_MUT
## S100a13 2.586559e-01 -2.3137318 0.197 0.177 1.000000e+00 CTL_MUT
## Hes7 2.594181e-01 1.5981275 0.154 0.004 1.000000e+00 CTL_MUT
## Plce1 2.607587e-01 1.6719872 0.107 0.044 1.000000e+00 CTL_MUT
## Hspa1l 2.622986e-01 -3.2308188 0.140 0.002 1.000000e+00 CTL_MUT
## Ephb1 2.640913e-01 1.6523880 0.243 0.216 1.000000e+00 CTL_MUT
## Prr5 2.645755e-01 -8.1637217 0.122 0.019 1.000000e+00 CTL_MUT
## 4930517O19Rik 2.658603e-01 -1.8325245 0.163 0.098 1.000000e+00 CTL_MUT
## Gm34455 2.753542e-01 -1.6430660 0.154 0.005 1.000000e+00 CTL_MUT
## Kirrel3 2.770090e-01 3.2390357 0.346 0.344 1.000000e+00 CTL_MUT
## Atp1a2 2.823503e-01 -5.1334410 0.265 0.293 1.000000e+00 CTL_MUT
## Il6ra 2.853890e-01 -2.8052430 0.155 0.023 1.000000e+00 CTL_MUT
## Sox5 2.869790e-01 -0.6435389 0.265 0.238 1.000000e+00 CTL_MUT
## Atox1 2.876970e-01 -1.6502715 0.350 0.330 1.000000e+00 CTL_MUT
## St8sia6 2.966570e-01 -1.6764960 0.135 0.016 1.000000e+00 CTL_MUT
## Clec4a3 2.970990e-01 0.4585368 0.108 0.003 1.000000e+00 CTL_MUT
## 1700016P03Rik 2.996333e-01 -6.7340095 0.153 0.121 1.000000e+00 CTL_MUT
## Sult1a1 3.038889e-01 1.0400819 0.197 0.011 1.000000e+00 CTL_MUT
## Cdh23 3.046333e-01 -0.8430620 0.115 0.010 1.000000e+00 CTL_MUT
## Adam12 3.063196e-01 -1.7236888 0.111 0.056 1.000000e+00 CTL_MUT
## Kif13b 3.084624e-01 9.0412072 0.202 0.191 1.000000e+00 CTL_MUT
## Hmgb2 3.103399e-01 -2.1180344 0.133 0.069 1.000000e+00 CTL_MUT
## Gpc6 3.119737e-01 0.8441061 0.247 0.234 1.000000e+00 CTL_MUT
## Stat3 3.124152e-01 -10.6364763 0.164 0.135 1.000000e+00 CTL_MUT
## Tiam1 3.161182e-01 0.4284034 0.259 0.262 1.000000e+00 CTL_MUT
## Myl1 3.228258e-01 -2.0430469 0.151 0.003 1.000000e+00 CTL_MUT
## Spata18 3.232298e-01 -0.7392166 0.124 0.002 1.000000e+00 CTL_MUT
## Arpc1b 3.250670e-01 -3.1946278 0.147 0.087 1.000000e+00 CTL_MUT
## Irf1 3.282435e-01 -0.7664592 0.156 0.023 1.000000e+00 CTL_MUT
## Osmr 3.301376e-01 3.3584752 0.127 0.012 1.000000e+00 CTL_MUT
## Tmem132d 3.353266e-01 1.9253225 0.269 0.227 1.000000e+00 CTL_MUT
## Pard3b 3.360055e-01 10.4427159 0.169 0.100 1.000000e+00 CTL_MUT
## Cenpe 3.369472e-01 -4.8738933 0.152 0.024 1.000000e+00 CTL_MUT
## Aebp1 3.370217e-01 3.6964191 0.130 0.020 1.000000e+00 CTL_MUT
## Jam2 3.389148e-01 -4.4710552 0.127 0.048 1.000000e+00 CTL_MUT
## Pid1 3.429985e-01 -0.7042906 0.247 0.204 1.000000e+00 CTL_MUT
## Nrg1 3.436484e-01 -2.9020348 0.317 0.299 1.000000e+00 CTL_MUT
## Gm45323 3.489734e-01 -0.8332140 0.122 0.006 1.000000e+00 CTL_MUT
## Rfx4 3.603313e-01 -1.0659517 0.116 0.075 1.000000e+00 CTL_MUT
## Mcl1 3.623570e-01 -0.4907843 0.189 0.163 1.000000e+00 CTL_MUT
## Mertk 3.705372e-01 -1.0727327 0.168 0.157 1.000000e+00 CTL_MUT
## Pappa2 3.877671e-01 -2.6361518 0.216 0.007 1.000000e+00 CTL_MUT
## Cyth4 3.932272e-01 5.1172052 0.126 0.023 1.000000e+00 CTL_MUT
## Gm26911 3.944002e-01 3.2159422 0.120 0.034 1.000000e+00 CTL_MUT
## Glud1 3.966835e-01 -1.3849562 0.217 0.229 1.000000e+00 CTL_MUT
## Mrvi1 3.974380e-01 -3.5028415 0.104 0.007 1.000000e+00 CTL_MUT
## Zic1 4.151245e-01 1.1649707 0.118 0.011 1.000000e+00 CTL_MUT
## Igf1r 4.253650e-01 -4.7001604 0.291 0.296 1.000000e+00 CTL_MUT
## Jcad 4.300378e-01 8.0866445 0.120 0.090 1.000000e+00 CTL_MUT
## Hcn1 4.301611e-01 -3.2974605 0.272 0.237 1.000000e+00 CTL_MUT
## Ifitm10 4.373127e-01 -3.6369180 0.172 0.057 1.000000e+00 CTL_MUT
## Txnip 4.491637e-01 -1.4174819 0.134 0.035 1.000000e+00 CTL_MUT
## Gm34544 4.508466e-01 -0.5869753 0.150 0.031 1.000000e+00 CTL_MUT
## Serpinh1 4.621965e-01 -3.9301165 0.109 0.019 1.000000e+00 CTL_MUT
## Rps4x 4.659506e-01 -0.6112651 0.385 0.411 1.000000e+00 CTL_MUT
## Srgn 4.688064e-01 -2.0409523 0.108 0.058 1.000000e+00 CTL_MUT
## Oprm1 4.786770e-01 -2.3096584 0.141 0.066 1.000000e+00 CTL_MUT
## Rasgef1b 4.821303e-01 1.1349742 0.249 0.215 1.000000e+00 CTL_MUT
## Gm21284 4.864736e-01 -2.2249565 0.164 0.003 1.000000e+00 CTL_MUT
## Gm13052 4.968405e-01 -1.3479694 0.140 0.062 1.000000e+00 CTL_MUT
## Dnajb1 5.008949e-01 2.0215820 0.116 0.121 1.000000e+00 CTL_MUT
## Usp29 5.030783e-01 5.8614537 0.224 0.201 1.000000e+00 CTL_MUT
## Elmo1 5.047450e-01 -1.3292291 0.230 0.234 1.000000e+00 CTL_MUT
## Arap1 5.056344e-01 3.1546997 0.164 0.018 1.000000e+00 CTL_MUT
## 1700007F19Rik 5.079153e-01 -5.2595235 0.124 0.030 1.000000e+00 CTL_MUT
## Sparcl1 5.104400e-01 2.3136706 0.365 0.376 1.000000e+00 CTL_MUT
## Gcnt2 5.118824e-01 -4.1980529 0.151 0.092 1.000000e+00 CTL_MUT
## Dusp16 5.126024e-01 0.7607306 0.156 0.126 1.000000e+00 CTL_MUT
## Ntm 5.129980e-01 -1.7902637 0.378 0.358 1.000000e+00 CTL_MUT
## Gm20383 5.194697e-01 -1.5361443 0.107 0.002 1.000000e+00 CTL_MUT
## Meis2 5.194823e-01 5.0802498 0.204 0.178 1.000000e+00 CTL_MUT
## Grp 5.217132e-01 2.7312265 0.147 0.029 1.000000e+00 CTL_MUT
## Selenop 5.232213e-01 7.9827390 0.183 0.160 1.000000e+00 CTL_MUT
## Gria4 5.348019e-01 -4.1573019 0.298 0.282 1.000000e+00 CTL_MUT
## Prox1 5.348154e-01 7.1077556 0.221 0.197 1.000000e+00 CTL_MUT
## Lyn 5.367693e-01 -1.4529307 0.119 0.103 1.000000e+00 CTL_MUT
## Ubash3b 5.383302e-01 3.0738216 0.210 0.195 1.000000e+00 CTL_MUT
## Birc5 5.384639e-01 -1.5692346 0.138 0.021 1.000000e+00 CTL_MUT
## Lmo4 5.513114e-01 -0.7168401 0.380 0.364 1.000000e+00 CTL_MUT
## Gm4876 5.631374e-01 -2.1558204 0.135 0.059 1.000000e+00 CTL_MUT
## Col4a1 5.664136e-01 -11.5488303 0.165 0.097 1.000000e+00 CTL_MUT
## Gstm5 5.711897e-01 -9.7609928 0.358 0.387 1.000000e+00 CTL_MUT
## Gm27252 5.773615e-01 0.7562864 0.154 0.003 1.000000e+00 CTL_MUT
## Col15a1 5.970475e-01 -2.6876208 0.125 0.010 1.000000e+00 CTL_MUT
## Ddr1 5.978717e-01 -4.3657719 0.130 0.093 1.000000e+00 CTL_MUT
## Trpv4 6.055903e-01 1.6375386 0.170 0.003 1.000000e+00 CTL_MUT
## Sema3e 6.071297e-01 3.8828614 0.174 0.110 1.000000e+00 CTL_MUT
## Fxyd5 6.125021e-01 -0.7436281 0.112 0.052 1.000000e+00 CTL_MUT
## Dapp1 6.150526e-01 0.5292147 0.107 0.029 1.000000e+00 CTL_MUT
## Parp4 6.159962e-01 2.0962466 0.172 0.017 1.000000e+00 CTL_MUT
## Yjefn3 6.171291e-01 0.9471297 0.181 0.083 1.000000e+00 CTL_MUT
## Slc35f1 6.240183e-01 -10.4023663 0.220 0.220 1.000000e+00 CTL_MUT
## Sv2b 6.260910e-01 -0.7293774 0.335 0.264 1.000000e+00 CTL_MUT
## Gm13872 6.292337e-01 -4.5975992 0.126 0.010 1.000000e+00 CTL_MUT
## Stard5 6.315383e-01 2.6079576 0.150 0.052 1.000000e+00 CTL_MUT
## Limch1 6.416154e-01 -0.7384694 0.328 0.363 1.000000e+00 CTL_MUT
## Ect2 6.417372e-01 -2.3815281 0.160 0.054 1.000000e+00 CTL_MUT
## Nfia 6.435474e-01 -9.0479429 0.348 0.369 1.000000e+00 CTL_MUT
## Rbpms 6.462544e-01 -0.8340543 0.112 0.042 1.000000e+00 CTL_MUT
## Rab31 6.542732e-01 -10.7651585 0.196 0.178 1.000000e+00 CTL_MUT
## Irf7 6.670751e-01 -1.9994083 0.127 0.005 1.000000e+00 CTL_MUT
## Itpkb 6.688921e-01 -1.8444799 0.155 0.085 1.000000e+00 CTL_MUT
## Rlbp1 6.704030e-01 -6.6057280 0.124 0.028 1.000000e+00 CTL_MUT
## Gm16599 6.822596e-01 1.7351153 0.154 0.086 1.000000e+00 CTL_MUT
## Gm20631 6.831712e-01 -3.2853636 0.106 0.004 1.000000e+00 CTL_MUT
## Kif26b 6.855815e-01 2.7383907 0.145 0.102 1.000000e+00 CTL_MUT
## Cntn4 6.955873e-01 -13.1483249 0.298 0.279 1.000000e+00 CTL_MUT
## Rbms1 6.986737e-01 1.1605647 0.157 0.126 1.000000e+00 CTL_MUT
## Timp2 7.046006e-01 -1.0786960 0.216 0.202 1.000000e+00 CTL_MUT
## Mt1 7.055143e-01 0.3714809 0.296 0.308 1.000000e+00 CTL_MUT
## Slc8b1 7.078388e-01 -1.4566467 0.148 0.015 1.000000e+00 CTL_MUT
## Npnt 7.106304e-01 1.7936447 0.156 0.090 1.000000e+00 CTL_MUT
## Pim1 7.124047e-01 2.3011992 0.141 0.017 1.000000e+00 CTL_MUT
## Trhde 7.168023e-01 1.7264289 0.236 0.206 1.000000e+00 CTL_MUT
## Pakap 7.181431e-01 0.3969962 0.294 0.280 1.000000e+00 CTL_MUT
## Tshz2 7.213081e-01 -1.4687531 0.184 0.219 1.000000e+00 CTL_MUT
## Myo16 7.263725e-01 -0.2796357 0.182 0.114 1.000000e+00 CTL_MUT
## Hmox1 7.356022e-01 3.2062168 0.200 0.007 1.000000e+00 CTL_MUT
## Kcnj10 7.461098e-01 5.3505810 0.150 0.124 1.000000e+00 CTL_MUT
## Clic1 7.518608e-01 2.5645787 0.131 0.050 1.000000e+00 CTL_MUT
## Gpc5 7.561802e-01 2.8390707 0.184 0.188 1.000000e+00 CTL_MUT
## H3f3b 7.572179e-01 -3.2215668 0.359 0.373 1.000000e+00 CTL_MUT
## Tmsb4x 7.617698e-01 -3.7187202 0.386 0.383 1.000000e+00 CTL_MUT
## Paqr8 7.621789e-01 2.2046795 0.157 0.145 1.000000e+00 CTL_MUT
## Gsdmd 7.652223e-01 2.9958683 0.113 0.004 1.000000e+00 CTL_MUT
## Pcdh7 7.664040e-01 0.2974970 0.350 0.348 1.000000e+00 CTL_MUT
## Il1rap 7.731319e-01 -0.8214802 0.269 0.283 1.000000e+00 CTL_MUT
## Lsp1 7.770416e-01 -2.6300074 0.113 0.010 1.000000e+00 CTL_MUT
## Uhrf1 7.815250e-01 -0.8318088 0.125 0.061 1.000000e+00 CTL_MUT
## Ckap2l 7.832701e-01 -1.1028304 0.103 0.016 1.000000e+00 CTL_MUT
## Endod1 8.046831e-01 0.6247962 0.149 0.134 1.000000e+00 CTL_MUT
## Gpr4 8.052394e-01 -2.2971367 0.142 0.009 1.000000e+00 CTL_MUT
## Parvg 8.181561e-01 -11.9452670 0.164 0.007 1.000000e+00 CTL_MUT
## Glul 8.242008e-01 1.8493951 0.300 0.342 1.000000e+00 CTL_MUT
## Synpo2 8.262363e-01 -8.7777481 0.169 0.021 1.000000e+00 CTL_MUT
## Shroom3 8.301106e-01 -1.4108227 0.122 0.026 1.000000e+00 CTL_MUT
## Gm10863 8.354196e-01 -1.3096732 0.101 0.021 1.000000e+00 CTL_MUT
## Prrt4 8.365723e-01 1.1022193 0.130 0.004 1.000000e+00 CTL_MUT
## Car4 8.436181e-01 2.1275732 0.130 0.077 1.000000e+00 CTL_MUT
## Hcrtr2 8.445241e-01 -2.0764091 0.109 0.009 1.000000e+00 CTL_MUT
## Trp53bp2 8.475455e-01 -0.7797958 0.158 0.081 1.000000e+00 CTL_MUT
## L3mbtl4 8.514033e-01 -0.3602668 0.122 0.014 1.000000e+00 CTL_MUT
## Sytl2 8.684806e-01 1.8578576 0.146 0.105 1.000000e+00 CTL_MUT
## Zeb1 8.756617e-01 -0.6841977 0.282 0.283 1.000000e+00 CTL_MUT
## Chn2 8.758173e-01 5.9214528 0.186 0.171 1.000000e+00 CTL_MUT
## Rbms3 8.765985e-01 -0.3980242 0.175 0.151 1.000000e+00 CTL_MUT
## Emp1 8.821898e-01 -1.1048393 0.160 0.005 1.000000e+00 CTL_MUT
## Rps9 8.870538e-01 2.3897701 0.386 0.404 1.000000e+00 CTL_MUT
## Gm44151 8.978459e-01 -3.6346713 0.251 0.170 1.000000e+00 CTL_MUT
## Nkain2 8.991648e-01 -1.2381386 0.379 0.375 1.000000e+00 CTL_MUT
## Tbx15 9.067422e-01 1.1087857 0.134 0.018 1.000000e+00 CTL_MUT
## Wfs1 9.189224e-01 7.9890276 0.156 0.101 1.000000e+00 CTL_MUT
## Rerg 9.348552e-01 -4.0653127 0.153 0.050 1.000000e+00 CTL_MUT
## Utrn 9.427996e-01 -0.6203840 0.158 0.160 1.000000e+00 CTL_MUT
## Frrs1 9.473432e-01 -0.8534406 0.122 0.014 1.000000e+00 CTL_MUT
## Sp140 9.486484e-01 -1.1089866 0.184 0.004 1.000000e+00 CTL_MUT
## S1pr2 9.565094e-01 0.6959014 0.139 0.003 1.000000e+00 CTL_MUT
## Psmb8 9.610828e-01 -5.8181065 0.108 0.013 1.000000e+00 CTL_MUT
## Chst11 9.624252e-01 -8.8280156 0.215 0.167 1.000000e+00 CTL_MUT
## Tgfbr1 9.653049e-01 3.4005628 0.110 0.108 1.000000e+00 CTL_MUT
## St8sia2 9.658244e-01 -9.4480541 0.124 0.012 1.000000e+00 CTL_MUT
## 1190005I06Rik 9.717229e-01 2.4563179 0.129 0.064 1.000000e+00 CTL_MUT
## Slc7a7 9.944187e-01 1.9466238 0.102 0.012 1.000000e+00 CTL_MUT
## Wipf1 9.957273e-01 1.5389850 0.154 0.104 1.000000e+00 CTL_MUTDifferential expression Analysis for cluster between groups
Next we will do DEG for each cluster betweent the two groups, and write the results to a csv file
Quatitative analysis of DEGs by each cluster
MAPK pathway gene plotting
Because we are interested in the MAPK1 pathway, we
select relevant genes for plotting
session info
Print session information
## R version 4.2.1 (2022-06-23 ucrt)
## Platform: x86_64-w64-mingw32/x64 (64-bit)
## Running under: Windows 10 x64 (build 19044)
##
## Matrix products: default
##
## locale:
## [1] LC_COLLATE=English_United States.utf8
## [2] LC_CTYPE=English_United States.utf8
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C
## [5] LC_TIME=English_United States.utf8
##
## attached base packages:
## [1] grid stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] celldex_1.6.0 SingleR_1.10.0
## [3] patchwork_1.1.1 circlize_0.4.15
## [5] RColorBrewer_1.1-3 ComplexHeatmap_2.12.0
## [7] SingleCellExperiment_1.18.0 SummarizedExperiment_1.26.1
## [9] Biobase_2.56.0 GenomicRanges_1.48.0
## [11] GenomeInfoDb_1.32.2 IRanges_2.30.0
## [13] S4Vectors_0.34.0 BiocGenerics_0.42.0
## [15] MatrixGenerics_1.8.1 matrixStats_0.62.0
## [17] rstatix_0.7.0 ggplot2_3.3.6
## [19] cowplot_1.1.1 dplyr_1.0.9
## [21] sp_1.5-0 SeuratObject_4.1.0
## [23] Seurat_4.1.1
##
## loaded via a namespace (and not attached):
## [1] utf8_1.2.2 reticulate_1.25
## [3] tidyselect_1.1.2 RSQLite_2.2.14
## [5] AnnotationDbi_1.58.0 htmlwidgets_1.5.4
## [7] BiocParallel_1.30.3 Rtsne_0.16
## [9] munsell_0.5.0 ScaledMatrix_1.4.0
## [11] codetools_0.2-18 ica_1.0-3
## [13] future_1.27.0 miniUI_0.1.1.1
## [15] withr_2.5.0 spatstat.random_2.2-0
## [17] colorspace_2.0-3 progressr_0.10.1
## [19] filelock_1.0.2 highr_0.9
## [21] knitr_1.39 rstudioapi_0.13
## [23] ROCR_1.0-11 tensor_1.5
## [25] listenv_0.8.0 labeling_0.4.2
## [27] GenomeInfoDbData_1.2.8 polyclip_1.10-0
## [29] pheatmap_1.0.12 bit64_4.0.5
## [31] farver_2.1.1 parallelly_1.32.1
## [33] vctrs_0.4.1 generics_0.1.3
## [35] xfun_0.31 BiocFileCache_2.4.0
## [37] R6_2.5.1 doParallel_1.0.17
## [39] clue_0.3-61 rsvd_1.0.5
## [41] bitops_1.0-7 spatstat.utils_2.3-1
## [43] cachem_1.0.6 DelayedArray_0.22.0
## [45] assertthat_0.2.1 promises_1.2.0.1
## [47] scales_1.2.0 rgeos_0.5-9
## [49] gtable_0.3.0 beachmat_2.12.0
## [51] globals_0.15.1 goftest_1.2-3
## [53] rlang_1.0.3 GlobalOptions_0.1.2
## [55] splines_4.2.1 lazyeval_0.2.2
## [57] spatstat.geom_2.4-0 broom_1.0.0
## [59] BiocManager_1.30.18 yaml_2.3.5
## [61] reshape2_1.4.4 abind_1.4-5
## [63] backports_1.4.1 httpuv_1.6.5
## [65] tools_4.2.1 ellipsis_0.3.2
## [67] spatstat.core_2.4-4 jquerylib_0.1.4
## [69] ggridges_0.5.3 Rcpp_1.0.8.3
## [71] plyr_1.8.7 sparseMatrixStats_1.8.0
## [73] zlibbioc_1.42.0 purrr_0.3.4
## [75] RCurl_1.98-1.7 rpart_4.1.16
## [77] deldir_1.0-6 viridis_0.6.2
## [79] pbapply_1.5-0 GetoptLong_1.0.5
## [81] zoo_1.8-10 ggrepel_0.9.1
## [83] cluster_2.1.3 magrittr_2.0.3
## [85] data.table_1.14.2 RSpectra_0.16-1
## [87] scattermore_0.8 lmtest_0.9-40
## [89] RANN_2.6.1 fitdistrplus_1.1-8
## [91] mime_0.12 evaluate_0.16
## [93] xtable_1.8-4 gridExtra_2.3
## [95] shape_1.4.6 compiler_4.2.1
## [97] tibble_3.1.7 KernSmooth_2.23-20
## [99] crayon_1.5.1 htmltools_0.5.2
## [101] mgcv_1.8-40 later_1.3.0
## [103] tidyr_1.2.0 DBI_1.1.3
## [105] ExperimentHub_2.4.0 dbplyr_2.2.1
## [107] rappdirs_0.3.3 MASS_7.3-57
## [109] Matrix_1.4-1 car_3.1-0
## [111] cli_3.3.0 parallel_4.2.1
## [113] igraph_1.3.2 pkgconfig_2.0.3
## [115] plotly_4.10.0 spatstat.sparse_2.1-1
## [117] foreach_1.5.2 bslib_0.4.0
## [119] XVector_0.36.0 stringr_1.4.0
## [121] digest_0.6.29 sctransform_0.3.3
## [123] RcppAnnoy_0.0.19 Biostrings_2.64.0
## [125] spatstat.data_2.2-0 rmarkdown_2.14
## [127] leiden_0.4.2 uwot_0.1.11
## [129] DelayedMatrixStats_1.18.0 curl_4.3.2
## [131] shiny_1.7.2 rjson_0.2.21
## [133] lifecycle_1.0.1 nlme_3.1-157
## [135] jsonlite_1.8.0 carData_3.0-5
## [137] BiocNeighbors_1.14.0 viridisLite_0.4.0
## [139] limma_3.52.2 fansi_1.0.3
## [141] pillar_1.8.0 lattice_0.20-45
## [143] KEGGREST_1.36.3 fastmap_1.1.0
## [145] httr_1.4.3 survival_3.3-1
## [147] interactiveDisplayBase_1.34.0 glue_1.6.2
## [149] png_0.1-7 iterators_1.0.14
## [151] BiocVersion_3.15.2 bit_4.0.4
## [153] stringi_1.7.6 sass_0.4.2
## [155] blob_1.2.3 AnnotationHub_3.4.0
## [157] BiocSingular_1.12.0 memoise_2.0.1
## [159] irlba_2.3.5 future.apply_1.9.0