We’re examining the GWAS catalog to find genes which are significantly associated with (a) diastolic blood pressure (DBP) and (b) systolic blood pressure (SBP).
In Sections 1A and 1B, we examine those genes which have been reported to be associated with DBP and SBP respectively by at least ten separate studies. Tables in either of these sections provide summary information on said genes, including information on minimum/maximum p-value reported and PUBMED IDs of studies which report association. Assuming it is convenient, I have collapsed sections 1A, 1B and 1D.
In Section 1C, we consider those genes which are common to both tables 1A and 1B. There are 20 such genes. I’m not sure if I’ll be able to analyse all of them, but it’s definitely something I’d like to try, if time permits!
In Section 1D we consider findings from Ehret, G. B., & Caulfield, M. J. (2013) which reports genes associated with SBP or DBP that were replicated in independent samples.
Found an article with a table of loci associated with SBP or DB that were replicated in independent samples. I’m including a list of genes (and chromosome positions reported in the table here). I’m not sure if the table above is more informative or the list below.
S(D)BP: systolic (diastolic) blood pressure; ETH: ethnicity (EU, individuals of European ancestry; AF, individuals of African-American or African origin; AS, individuals of Asian origin; NA, not available); The effect sizes (ES) and P-values (pVal) are taken from the report with the larger sample size if several reports were available.