ISDIN MARZO 2022 (CPC,CY,CPC+CY,Placebo) - Substantivity of mouth-rinse formulations containing cetylpyridinium chloride and O-cymen-5-ol
#packages
library("patchwork")
library("tidyverse")
library("performance")
library("ggpubr")
library("Rmisc")
options(max.print=999999)#grafica
#bonferroni
pairwise.t.test( df$Reduccion,
df$Colutorio,
p.adj = "bonferroni")
Pairwise comparisons using t tests with pooled SD
data: df$Reduccion and df$Colutorio
CPC (97) CPC+Cy(89) CY(98)
CPC+Cy(89) 1.000 - -
CY(98) 1.3e-05 2.0e-08 -
Placebo 1.0e-11 3.5e-15 0.033
P value adjustment method: bonferroni #modelo de aov
summary(aov1)
Df Sum Sq Mean Sq F value Pr(>F)
Tiempo 6 41088 6848 18.573 < 2e-16 ***
Colutorio 3 47222 15741 42.692 < 2e-16 ***
Tiempo:Colutorio 18 14374 799 2.166 0.00415 **
Residuals 343 126464 369
---
Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1#tukey
TukeyHSD(aov1)
Tukey multiple comparisons of means
95% family-wise confidence level
Fit: aov(formula = Reduccion ~ Tiempo + Colutorio + Tiempo * Colutorio, data = df)
$Tiempo
diff lwr upr p adj
T1-T0 -33.722642 -44.7856708 -22.659612 0.0000000
T2-T0 -28.352830 -39.4158595 -17.289801 0.0000000
T3-T0 -23.290566 -34.3535953 -12.227537 0.0000000
T4-T0 -19.800000 -30.8630293 -8.736971 0.0000041
T5-T0 -17.098113 -28.1611425 -6.035084 0.0001295
T6-T0 -9.645283 -20.7083123 1.417746 0.1335349
T2-T1 5.369811 -5.6932180 16.432841 0.7798751
T3-T1 10.432075 -0.6309538 21.495105 0.0791656
T4-T1 13.922642 2.8596122 24.985671 0.0041321
T5-T1 16.624528 5.5614990 27.687558 0.0002264
T6-T1 24.077358 13.0143292 35.140388 0.0000000
T3-T2 5.062264 -6.0007651 16.125293 0.8240110
T4-T2 8.552830 -2.5101991 19.615859 0.2503644
T5-T2 11.254717 0.1916877 22.317746 0.0431881
T6-T2 18.707547 7.6445179 29.770576 0.0000175
T4-T3 3.490566 -7.5724632 14.553595 0.9665176
T5-T3 6.192453 -4.8705764 17.255482 0.6431039
T6-T3 13.645283 2.5822537 24.708312 0.0054097
T5-T4 2.701887 -8.3611425 13.764916 0.9910432
T6-T4 10.154717 -0.9083123 21.217746 0.0958063
T6-T5 7.452830 -3.6101991 18.515859 0.4177653
$Colutorio
diff lwr upr p adj
CPC+Cy(89)-CPC (97) -3.940816 -11.022526 3.140894 0.4773483
CY(98)-CPC (97) 15.337755 8.256045 22.419465 0.0000003
Placebo-CPC (97) 24.790909 17.241781 32.340037 0.0000000
CY(98)-CPC+Cy(89) 19.278571 12.196861 26.360281 0.0000000
Placebo-CPC+Cy(89) 28.731725 21.182597 36.280854 0.0000000
Placebo-CY(98) 9.453154 1.904026 17.002282 0.0073222
$`Tiempo:Colutorio`
diff lwr upr p adj
T1:CPC (97)-T0:CPC (97) -5.101429e+01 -78.20385258 -23.8247188 0.0000000
T2:CPC (97)-T0:CPC (97) -4.174286e+01 -68.93242401 -14.5532903 0.0000072
T3:CPC (97)-T0:CPC (97) -3.510714e+01 -62.29670973 -7.9175760 0.0006738
T4:CPC (97)-T0:CPC (97) -3.015000e+01 -57.33956687 -2.9604331 0.0118032
T5:CPC (97)-T0:CPC (97) -2.199286e+01 -49.18242401 5.1967097 0.3396837
T6:CPC (97)-T0:CPC (97) -8.992857e+00 -36.18242401 18.1967097 0.9999872
T0:CPC+Cy(89)-T0:CPC (97) 0.000000e+00 -27.18956687 27.1895669 1.0000000
T1:CPC+Cy(89)-T0:CPC (97) -5.062143e+01 -77.81099544 -23.4318617 0.0000000
T2:CPC+Cy(89)-T0:CPC (97) -4.518571e+01 -72.37528116 -17.9961474 0.0000005
T3:CPC+Cy(89)-T0:CPC (97) -3.637857e+01 -63.56813830 -9.1890046 0.0002991
T4:CPC+Cy(89)-T0:CPC (97) -3.251429e+01 -59.70385258 -5.3247188 0.0032102
T5:CPC+Cy(89)-T0:CPC (97) -3.220714e+01 -59.39670973 -5.0175760 0.0038280
T6:CPC+Cy(89)-T0:CPC (97) -1.967857e+01 -46.86813830 7.5109954 0.5852120
T0:CY(98)-T0:CPC (97) -1.136868e-13 -27.18956687 27.1895669 1.0000000
T1:CY(98)-T0:CPC (97) -2.019286e+01 -47.38242401 6.9967097 0.5280702
T2:CY(98)-T0:CPC (97) -1.727857e+01 -44.46813830 9.9109954 0.8251753
T3:CY(98)-T0:CPC (97) -1.489286e+01 -42.08242401 12.2967097 0.9585784
T4:CY(98)-T0:CPC (97) -1.200714e+01 -39.19670973 15.1824240 0.9977421
T5:CY(98)-T0:CPC (97) -9.621429e+00 -36.81099544 17.5681383 0.9999523
T6:CY(98)-T0:CPC (97) -7.642857e+00 -34.83242401 19.5467097 0.9999996
T0:Placebo-T0:CPC (97) -5.684342e-14 -28.98417567 28.9841757 1.0000000
T1:Placebo-T0:CPC (97) -7.427273e+00 -36.41144840 21.5569029 0.9999999
T2:Placebo-T0:CPC (97) -3.981818e+00 -32.96599385 25.0023575 1.0000000
T3:Placebo-T0:CPC (97) -2.281818e+00 -31.26599385 26.7023575 1.0000000
T4:Placebo-T0:CPC (97) -3.636364e-01 -29.34781203 28.6205393 1.0000000
T5:Placebo-T0:CPC (97) -1.154545e+00 -30.13872112 27.8296302 1.0000000
T6:Placebo-T0:CPC (97) -2.545455e-01 -29.23872112 28.7296302 1.0000000
T2:CPC (97)-T1:CPC (97) 9.271429e+00 -17.91813830 36.4609954 0.9999767
T3:CPC (97)-T1:CPC (97) 1.590714e+01 -11.28242401 43.0967097 0.9167309
T4:CPC (97)-T1:CPC (97) 2.086429e+01 -6.32528116 48.0538526 0.4545794
T5:CPC (97)-T1:CPC (97) 2.902143e+01 1.83186170 56.2109954 0.0210052
T6:CPC (97)-T1:CPC (97) 4.202143e+01 14.83186170 69.2109954 0.0000059
T0:CPC+Cy(89)-T1:CPC (97) 5.101429e+01 23.82471884 78.2038526 0.0000000
T1:CPC+Cy(89)-T1:CPC (97) 3.928571e-01 -26.79670973 27.5824240 1.0000000
T2:CPC+Cy(89)-T1:CPC (97) 5.828571e+00 -21.36099544 33.0181383 1.0000000
T3:CPC+Cy(89)-T1:CPC (97) 1.463571e+01 -12.55385258 41.8252812 0.9660944
T4:CPC+Cy(89)-T1:CPC (97) 1.850000e+01 -8.68956687 45.6895669 0.7120278
T5:CPC+Cy(89)-T1:CPC (97) 1.880714e+01 -8.38242401 45.9967097 0.6800916
T6:CPC+Cy(89)-T1:CPC (97) 3.133571e+01 4.14614742 58.5252812 0.0062386
T0:CY(98)-T1:CPC (97) 5.101429e+01 23.82471884 78.2038526 0.0000000
T1:CY(98)-T1:CPC (97) 3.082143e+01 3.63186170 58.0109954 0.0082582
T2:CY(98)-T1:CPC (97) 3.373571e+01 6.54614742 60.9252812 0.0015641
T3:CY(98)-T1:CPC (97) 3.612143e+01 8.93186170 63.3109954 0.0003533
T4:CY(98)-T1:CPC (97) 3.900714e+01 11.81757599 66.1967097 0.0000510
T5:CY(98)-T1:CPC (97) 4.139286e+01 14.20329027 68.5824240 0.0000093
T6:CY(98)-T1:CPC (97) 4.337143e+01 16.18186170 70.5609954 0.0000021
T0:Placebo-T1:CPC (97) 5.101429e+01 22.03011004 79.9984614 0.0000001
T1:Placebo-T1:CPC (97) 4.358701e+01 14.60283732 72.5711887 0.0000134
T2:Placebo-T1:CPC (97) 4.703247e+01 18.04829186 76.0166432 0.0000012
T3:Placebo-T1:CPC (97) 4.873247e+01 19.74829186 77.7166432 0.0000003
T4:Placebo-T1:CPC (97) 5.065065e+01 21.66647368 79.6348250 0.0000001
T5:Placebo-T1:CPC (97) 4.985974e+01 20.87556459 78.8439159 0.0000001
T6:Placebo-T1:CPC (97) 5.075974e+01 21.77556459 79.7439159 0.0000001
T3:CPC (97)-T2:CPC (97) 6.635714e+00 -20.55385258 33.8252812 1.0000000
T4:CPC (97)-T2:CPC (97) 1.159286e+01 -15.59670973 38.7824240 0.9987078
T5:CPC (97)-T2:CPC (97) 1.975000e+01 -7.43956687 46.9395669 0.5772816
T6:CPC (97)-T2:CPC (97) 3.275000e+01 5.56043313 59.9395669 0.0028009
T0:CPC+Cy(89)-T2:CPC (97) 4.174286e+01 14.55329027 68.9324240 0.0000072
T1:CPC+Cy(89)-T2:CPC (97) -8.878571e+00 -36.06813830 18.3109954 0.9999901
T2:CPC+Cy(89)-T2:CPC (97) -3.442857e+00 -30.63242401 23.7467097 1.0000000
T3:CPC+Cy(89)-T2:CPC (97) 5.364286e+00 -21.82528116 32.5538526 1.0000000
T4:CPC+Cy(89)-T2:CPC (97) 9.228571e+00 -17.96099544 36.4181383 0.9999787
T5:CPC+Cy(89)-T2:CPC (97) 9.535714e+00 -17.65385258 36.7252812 0.9999598
T6:CPC+Cy(89)-T2:CPC (97) 2.206429e+01 -5.12528116 49.2538526 0.3329335
T0:CY(98)-T2:CPC (97) 4.174286e+01 14.55329027 68.9324240 0.0000072
T1:CY(98)-T2:CPC (97) 2.155000e+01 -5.63956687 48.7395669 0.3830496
T2:CY(98)-T2:CPC (97) 2.446429e+01 -2.72528116 51.6538526 0.1524392
T3:CY(98)-T2:CPC (97) 2.685000e+01 -0.33956687 54.0395669 0.0581412
T4:CY(98)-T2:CPC (97) 2.973571e+01 2.54614742 56.9252812 0.0146364
T5:CY(98)-T2:CPC (97) 3.212143e+01 4.93186170 59.3109954 0.0040193
T6:CY(98)-T2:CPC (97) 3.410000e+01 6.91043313 61.2895669 0.0012550
T0:Placebo-T2:CPC (97) 4.174286e+01 12.75868147 70.7270328 0.0000459
T1:Placebo-T2:CPC (97) 3.431558e+01 5.33140875 63.2997601 0.0038636
T2:Placebo-T2:CPC (97) 3.776104e+01 8.77686329 66.7452146 0.0005522
T3:Placebo-T2:CPC (97) 3.946104e+01 10.47686329 68.4452146 0.0001967
T4:Placebo-T2:CPC (97) 4.137922e+01 12.39504511 70.3633964 0.0000582
T5:Placebo-T2:CPC (97) 4.058831e+01 11.60413602 69.5724874 0.0000968
T6:Placebo-T2:CPC (97) 4.148831e+01 12.50413602 70.4724874 0.0000542
T4:CPC (97)-T3:CPC (97) 4.957143e+00 -22.23242401 32.1467097 1.0000000
T5:CPC (97)-T3:CPC (97) 1.311429e+01 -14.07528116 40.3038526 0.9916964
T6:CPC (97)-T3:CPC (97) 2.611429e+01 -1.07528116 53.3038526 0.0797134
T0:CPC+Cy(89)-T3:CPC (97) 3.510714e+01 7.91757599 62.2967097 0.0006738
T1:CPC+Cy(89)-T3:CPC (97) -1.551429e+01 -42.70385258 11.6752812 0.9354037
T2:CPC+Cy(89)-T3:CPC (97) -1.007857e+01 -37.26813830 17.1109954 0.9998860
T3:CPC+Cy(89)-T3:CPC (97) -1.271429e+00 -28.46099544 25.9181383 1.0000000
T4:CPC+Cy(89)-T3:CPC (97) 2.592857e+00 -24.59670973 29.7824240 1.0000000
T5:CPC+Cy(89)-T3:CPC (97) 2.900000e+00 -24.28956687 30.0895669 1.0000000
T6:CPC+Cy(89)-T3:CPC (97) 1.542857e+01 -11.76099544 42.6181383 0.9390499
T0:CY(98)-T3:CPC (97) 3.510714e+01 7.91757599 62.2967097 0.0006738
T1:CY(98)-T3:CPC (97) 1.491429e+01 -12.27528116 42.1038526 0.9579002
T2:CY(98)-T3:CPC (97) 1.782857e+01 -9.36099544 45.0181383 0.7773932
T3:CY(98)-T3:CPC (97) 2.021429e+01 -6.97528116 47.4038526 0.5256949
T4:CY(98)-T3:CPC (97) 2.310000e+01 -4.08956687 50.2895669 0.2436578
T5:CY(98)-T3:CPC (97) 2.548571e+01 -1.70385258 52.6752812 0.1030675
T6:CY(98)-T3:CPC (97) 2.746429e+01 0.27471884 54.6538526 0.0441521
T0:Placebo-T3:CPC (97) 3.510714e+01 6.12296719 64.0913185 0.0025169
T1:Placebo-T3:CPC (97) 2.767987e+01 -1.30430554 56.6640458 0.0847848
T2:Placebo-T3:CPC (97) 3.112532e+01 2.14114901 60.1095003 0.0192316
T3:Placebo-T3:CPC (97) 3.282532e+01 3.84114901 61.8095003 0.0083863
T4:Placebo-T3:CPC (97) 3.474351e+01 5.75933082 63.7276822 0.0030689
T5:Placebo-T3:CPC (97) 3.395260e+01 4.96842173 62.9367731 0.0046846
T6:Placebo-T3:CPC (97) 3.485260e+01 5.86842173 63.8367731 0.0028924
T5:CPC (97)-T4:CPC (97) 8.157143e+00 -19.03242401 35.3467097 0.9999983
T6:CPC (97)-T4:CPC (97) 2.115714e+01 -6.03242401 48.3467097 0.4234683
T0:CPC+Cy(89)-T4:CPC (97) 3.015000e+01 2.96043313 57.3395669 0.0118032
T1:CPC+Cy(89)-T4:CPC (97) -2.047143e+01 -47.66099544 6.7181383 0.4973074
T2:CPC+Cy(89)-T4:CPC (97) -1.503571e+01 -42.22528116 12.1538526 0.9539006
T3:CPC+Cy(89)-T4:CPC (97) -6.228571e+00 -33.41813830 20.9609954 1.0000000
T4:CPC+Cy(89)-T4:CPC (97) -2.364286e+00 -29.55385258 24.8252812 1.0000000
T5:CPC+Cy(89)-T4:CPC (97) -2.057143e+00 -29.24670973 25.1324240 1.0000000
T6:CPC+Cy(89)-T4:CPC (97) 1.047143e+01 -16.71813830 37.6609954 0.9997719
T0:CY(98)-T4:CPC (97) 3.015000e+01 2.96043313 57.3395669 0.0118032
T1:CY(98)-T4:CPC (97) 9.957143e+00 -17.23242401 37.1467097 0.9999089
T2:CY(98)-T4:CPC (97) 1.287143e+01 -14.31813830 40.0609954 0.9936210
T3:CY(98)-T4:CPC (97) 1.525714e+01 -11.93242401 42.4467097 0.9458992
T4:CY(98)-T4:CPC (97) 1.814286e+01 -9.04670973 45.3324240 0.7476528
T5:CY(98)-T4:CPC (97) 2.052857e+01 -6.66099544 47.7181383 0.4910363
T6:CY(98)-T4:CPC (97) 2.250714e+01 -4.68242401 49.6967097 0.2927321
T0:Placebo-T4:CPC (97) 3.015000e+01 1.16582433 59.1341757 0.0301085
T1:Placebo-T4:CPC (97) 2.272273e+01 -6.26144840 51.7069029 0.4069458
T2:Placebo-T4:CPC (97) 2.616818e+01 -2.81599385 55.1523575 0.1478167
T3:Placebo-T4:CPC (97) 2.786818e+01 -1.11599385 56.8523575 0.0787718
T4:Placebo-T4:CPC (97) 2.978636e+01 0.80218797 58.7705393 0.0353903
T5:Placebo-T4:CPC (97) 2.899545e+01 0.01127888 57.9796302 0.0497630
T6:Placebo-T4:CPC (97) 2.989545e+01 0.91127888 58.8796302 0.0337260
T6:CPC (97)-T5:CPC (97) 1.300000e+01 -14.18956687 40.1895669 0.9926546
T0:CPC+Cy(89)-T5:CPC (97) 2.199286e+01 -5.19670973 49.1824240 0.3396837
T1:CPC+Cy(89)-T5:CPC (97) -2.862857e+01 -55.81813830 -1.4390046 0.0254851
T2:CPC+Cy(89)-T5:CPC (97) -2.319286e+01 -50.38242401 3.9967097 0.2364848
T3:CPC+Cy(89)-T5:CPC (97) -1.438571e+01 -41.57528116 12.8038526 0.9723620
T4:CPC+Cy(89)-T5:CPC (97) -1.052143e+01 -37.71099544 16.6681383 0.9997517
T5:CPC+Cy(89)-T5:CPC (97) -1.021429e+01 -37.40385258 16.9752812 0.9998544
T6:CPC+Cy(89)-T5:CPC (97) 2.314286e+00 -24.87528116 29.5038526 1.0000000
T0:CY(98)-T5:CPC (97) 2.199286e+01 -5.19670973 49.1824240 0.3396837
T1:CY(98)-T5:CPC (97) 1.800000e+00 -25.38956687 28.9895669 1.0000000
T2:CY(98)-T5:CPC (97) 4.714286e+00 -22.47528116 31.9038526 1.0000000
T3:CY(98)-T5:CPC (97) 7.100000e+00 -20.08956687 34.2895669 0.9999999
T4:CY(98)-T5:CPC (97) 9.985714e+00 -17.20385258 37.1752812 0.9999040
T5:CY(98)-T5:CPC (97) 1.237143e+01 -14.81813830 39.5609954 0.9964319
T6:CY(98)-T5:CPC (97) 1.435000e+01 -12.83956687 41.5395669 0.9731789
T0:Placebo-T5:CPC (97) 2.199286e+01 -6.99131853 50.9770328 0.4798243
T1:Placebo-T5:CPC (97) 1.456558e+01 -14.41859125 43.5497601 0.9855383
T2:Placebo-T5:CPC (97) 1.801104e+01 -10.97313671 46.9952146 0.8548446
T3:Placebo-T5:CPC (97) 1.971104e+01 -9.27313671 48.6952146 0.7129883
T4:Placebo-T5:CPC (97) 2.162922e+01 -7.35495489 50.6133964 0.5173115
T5:Placebo-T5:CPC (97) 2.083831e+01 -8.14586398 49.8224874 0.5996707
T6:Placebo-T5:CPC (97) 2.173831e+01 -7.24586398 50.7224874 0.5060114
T0:CPC+Cy(89)-T6:CPC (97) 8.992857e+00 -18.19670973 36.1824240 0.9999872
T1:CPC+Cy(89)-T6:CPC (97) -4.162857e+01 -68.81813830 -14.4390046 0.0000078
T2:CPC+Cy(89)-T6:CPC (97) -3.619286e+01 -63.38242401 -9.0032903 0.0003374
T3:CPC+Cy(89)-T6:CPC (97) -2.738571e+01 -54.57528116 -0.1961474 0.0457608
T4:CPC+Cy(89)-T6:CPC (97) -2.352143e+01 -50.71099544 3.6681383 0.2122393
T5:CPC+Cy(89)-T6:CPC (97) -2.321429e+01 -50.40385258 3.9752812 0.2348495
T6:CPC+Cy(89)-T6:CPC (97) -1.068571e+01 -37.87528116 16.5038526 0.9996735
T0:CY(98)-T6:CPC (97) 8.992857e+00 -18.19670973 36.1824240 0.9999872
T1:CY(98)-T6:CPC (97) -1.120000e+01 -38.38956687 15.9895669 0.9992682
T2:CY(98)-T6:CPC (97) -8.285714e+00 -35.47528116 18.9038526 0.9999976
T3:CY(98)-T6:CPC (97) -5.900000e+00 -33.08956687 21.2895669 1.0000000
T4:CY(98)-T6:CPC (97) -3.014286e+00 -30.20385258 24.1752812 1.0000000
T5:CY(98)-T6:CPC (97) -6.285714e-01 -27.81813830 26.5609954 1.0000000
T6:CY(98)-T6:CPC (97) 1.350000e+00 -25.83956687 28.5395669 1.0000000
T0:Placebo-T6:CPC (97) 8.992857e+00 -19.99131853 37.9770328 0.9999965
T1:Placebo-T6:CPC (97) 1.565584e+00 -27.41859125 30.5497601 1.0000000
T2:Placebo-T6:CPC (97) 5.011039e+00 -23.97313671 33.9952146 1.0000000
T3:Placebo-T6:CPC (97) 6.711039e+00 -22.27313671 35.6952146 1.0000000
T4:Placebo-T6:CPC (97) 8.629221e+00 -20.35495489 37.6133964 0.9999985
T5:Placebo-T6:CPC (97) 7.838312e+00 -21.14586398 36.8224874 0.9999998
T6:Placebo-T6:CPC (97) 8.738312e+00 -20.24586398 37.7224874 0.9999981
T1:CPC+Cy(89)-T0:CPC+Cy(89) -5.062143e+01 -77.81099544 -23.4318617 0.0000000
T2:CPC+Cy(89)-T0:CPC+Cy(89) -4.518571e+01 -72.37528116 -17.9961474 0.0000005
T3:CPC+Cy(89)-T0:CPC+Cy(89) -3.637857e+01 -63.56813830 -9.1890046 0.0002991
T4:CPC+Cy(89)-T0:CPC+Cy(89) -3.251429e+01 -59.70385258 -5.3247188 0.0032102
T5:CPC+Cy(89)-T0:CPC+Cy(89) -3.220714e+01 -59.39670973 -5.0175760 0.0038280
T6:CPC+Cy(89)-T0:CPC+Cy(89) -1.967857e+01 -46.86813830 7.5109954 0.5852120
T0:CY(98)-T0:CPC+Cy(89) -1.136868e-13 -27.18956687 27.1895669 1.0000000
T1:CY(98)-T0:CPC+Cy(89) -2.019286e+01 -47.38242401 6.9967097 0.5280702
T2:CY(98)-T0:CPC+Cy(89) -1.727857e+01 -44.46813830 9.9109954 0.8251753
T3:CY(98)-T0:CPC+Cy(89) -1.489286e+01 -42.08242401 12.2967097 0.9585784
T4:CY(98)-T0:CPC+Cy(89) -1.200714e+01 -39.19670973 15.1824240 0.9977421
T5:CY(98)-T0:CPC+Cy(89) -9.621429e+00 -36.81099544 17.5681383 0.9999523
T6:CY(98)-T0:CPC+Cy(89) -7.642857e+00 -34.83242401 19.5467097 0.9999996
T0:Placebo-T0:CPC+Cy(89) -5.684342e-14 -28.98417567 28.9841757 1.0000000
T1:Placebo-T0:CPC+Cy(89) -7.427273e+00 -36.41144840 21.5569029 0.9999999
T2:Placebo-T0:CPC+Cy(89) -3.981818e+00 -32.96599385 25.0023575 1.0000000
T3:Placebo-T0:CPC+Cy(89) -2.281818e+00 -31.26599385 26.7023575 1.0000000
T4:Placebo-T0:CPC+Cy(89) -3.636364e-01 -29.34781203 28.6205393 1.0000000
T5:Placebo-T0:CPC+Cy(89) -1.154545e+00 -30.13872112 27.8296302 1.0000000
T6:Placebo-T0:CPC+Cy(89) -2.545455e-01 -29.23872112 28.7296302 1.0000000
T2:CPC+Cy(89)-T1:CPC+Cy(89) 5.435714e+00 -21.75385258 32.6252812 1.0000000
T3:CPC+Cy(89)-T1:CPC+Cy(89) 1.424286e+01 -12.94670973 41.4324240 0.9755179
T4:CPC+Cy(89)-T1:CPC+Cy(89) 1.810714e+01 -9.08242401 45.2967097 0.7511130
T5:CPC+Cy(89)-T1:CPC+Cy(89) 1.841429e+01 -8.77528116 45.6038526 0.7207383
T6:CPC+Cy(89)-T1:CPC+Cy(89) 3.094286e+01 3.75329027 58.1324240 0.0077332
T0:CY(98)-T1:CPC+Cy(89) 5.062143e+01 23.43186170 77.8109954 0.0000000
T1:CY(98)-T1:CPC+Cy(89) 3.042857e+01 3.23900456 57.6181383 0.0101904
T2:CY(98)-T1:CPC+Cy(89) 3.334286e+01 6.15329027 60.5324240 0.0019776
T3:CY(98)-T1:CPC+Cy(89) 3.572857e+01 8.53900456 62.9181383 0.0004547
T4:CY(98)-T1:CPC+Cy(89) 3.861429e+01 11.42471884 65.8038526 0.0000670
T5:CY(98)-T1:CPC+Cy(89) 4.100000e+01 13.81043313 68.1895669 0.0000124
T6:CY(98)-T1:CPC+Cy(89) 4.297857e+01 15.78900456 70.1681383 0.0000029
T0:Placebo-T1:CPC+Cy(89) 5.062143e+01 21.63725290 79.6056042 0.0000001
T1:Placebo-T1:CPC+Cy(89) 4.319416e+01 14.20998017 72.1783315 0.0000175
T2:Placebo-T1:CPC+Cy(89) 4.663961e+01 17.65543472 75.6237861 0.0000016
T3:Placebo-T1:CPC+Cy(89) 4.833961e+01 19.35543472 77.3237861 0.0000005
T4:Placebo-T1:CPC+Cy(89) 5.025779e+01 21.27361654 79.2419679 0.0000001
T5:Placebo-T1:CPC+Cy(89) 4.946688e+01 20.48270745 78.4510588 0.0000002
T6:Placebo-T1:CPC+Cy(89) 5.036688e+01 21.38270745 79.3510588 0.0000001
T3:CPC+Cy(89)-T2:CPC+Cy(89) 8.807143e+00 -18.38242401 35.9967097 0.9999916
T4:CPC+Cy(89)-T2:CPC+Cy(89) 1.267143e+01 -14.51813830 39.8609954 0.9949118
T5:CPC+Cy(89)-T2:CPC+Cy(89) 1.297857e+01 -14.21099544 40.1681383 0.9928237
T6:CPC+Cy(89)-T2:CPC+Cy(89) 2.550714e+01 -1.68242401 52.6967097 0.1021888
T0:CY(98)-T2:CPC+Cy(89) 4.518571e+01 17.99614742 72.3752812 0.0000005
T1:CY(98)-T2:CPC+Cy(89) 2.499286e+01 -2.19670973 52.1824240 0.1250071
T2:CY(98)-T2:CPC+Cy(89) 2.790714e+01 0.71757599 55.0967097 0.0359750
T3:CY(98)-T2:CPC+Cy(89) 3.029286e+01 3.10329027 57.4824240 0.0109490
T4:CY(98)-T2:CPC+Cy(89) 3.317857e+01 5.98900456 60.3681383 0.0021794
T5:CY(98)-T2:CPC+Cy(89) 3.556429e+01 8.37471884 62.7538526 0.0005049
T6:CY(98)-T2:CPC+Cy(89) 3.754286e+01 10.35329027 64.7324240 0.0001387
T0:Placebo-T2:CPC+Cy(89) 4.518571e+01 16.20153862 74.1698900 0.0000045
T1:Placebo-T2:CPC+Cy(89) 3.775844e+01 8.77426589 66.7426172 0.0005530
T2:Placebo-T2:CPC+Cy(89) 4.120390e+01 12.21972043 70.1880718 0.0000652
T3:Placebo-T2:CPC+Cy(89) 4.290390e+01 13.91972043 71.8880718 0.0000213
T4:Placebo-T2:CPC+Cy(89) 4.482208e+01 15.83790225 73.8062536 0.0000057
T5:Placebo-T2:CPC+Cy(89) 4.403117e+01 15.04699316 73.0153445 0.0000099
T6:Placebo-T2:CPC+Cy(89) 4.493117e+01 15.94699316 73.9153445 0.0000053
T4:CPC+Cy(89)-T3:CPC+Cy(89) 3.864286e+00 -23.32528116 31.0538526 1.0000000
T5:CPC+Cy(89)-T3:CPC+Cy(89) 4.171429e+00 -23.01813830 31.3609954 1.0000000
T6:CPC+Cy(89)-T3:CPC+Cy(89) 1.670000e+01 -10.48956687 43.8895669 0.8688148
T0:CY(98)-T3:CPC+Cy(89) 3.637857e+01 9.18900456 63.5681383 0.0002991
T1:CY(98)-T3:CPC+Cy(89) 1.618571e+01 -11.00385258 43.3752812 0.9014767
T2:CY(98)-T3:CPC+Cy(89) 1.910000e+01 -8.08956687 46.2895669 0.6487588
T3:CY(98)-T3:CPC+Cy(89) 2.148571e+01 -5.70385258 48.6752812 0.3895474
T4:CY(98)-T3:CPC+Cy(89) 2.437143e+01 -2.81813830 51.5609954 0.1576978
T5:CY(98)-T3:CPC+Cy(89) 2.675714e+01 -0.43242401 53.9467097 0.0605555
T6:CY(98)-T3:CPC+Cy(89) 2.873571e+01 1.54614742 55.9252812 0.0241855
T0:Placebo-T3:CPC+Cy(89) 3.637857e+01 7.39439576 65.3627471 0.0012352
T1:Placebo-T3:CPC+Cy(89) 2.895130e+01 -0.03287697 57.9354744 0.0506965
T2:Placebo-T3:CPC+Cy(89) 3.239675e+01 3.41257758 61.3809289 0.0103962
T3:Placebo-T3:CPC+Cy(89) 3.409675e+01 5.11257758 63.0809289 0.0043408
T4:Placebo-T3:CPC+Cy(89) 3.601494e+01 7.03075939 64.9991107 0.0015185
T5:Placebo-T3:CPC+Cy(89) 3.522403e+01 6.23985030 64.2082016 0.0023603
T6:Placebo-T3:CPC+Cy(89) 3.612403e+01 7.13985030 65.1082016 0.0014276
T5:CPC+Cy(89)-T4:CPC+Cy(89) 3.071429e-01 -26.88242401 27.4967097 1.0000000
T6:CPC+Cy(89)-T4:CPC+Cy(89) 1.283571e+01 -14.35385258 40.0252812 0.9938697
T0:CY(98)-T4:CPC+Cy(89) 3.251429e+01 5.32471884 59.7038526 0.0032102
T1:CY(98)-T4:CPC+Cy(89) 1.232143e+01 -14.86813830 39.5109954 0.9966432
T2:CY(98)-T4:CPC+Cy(89) 1.523571e+01 -11.95385258 42.4252812 0.9467146
T3:CY(98)-T4:CPC+Cy(89) 1.762143e+01 -9.56813830 44.8109954 0.7960620
T4:CY(98)-T4:CPC+Cy(89) 2.050714e+01 -6.68242401 47.6967097 0.4933861
T5:CY(98)-T4:CPC+Cy(89) 2.289286e+01 -4.29670973 50.0824240 0.2601651
T6:CY(98)-T4:CPC+Cy(89) 2.487143e+01 -2.31813830 52.0609954 0.1309405
T0:Placebo-T4:CPC+Cy(89) 3.251429e+01 3.53011004 61.4984614 0.0098050
T1:Placebo-T4:CPC+Cy(89) 2.508701e+01 -3.89716268 54.0711887 0.2113679
T2:Placebo-T4:CPC+Cy(89) 2.853247e+01 -0.45170814 57.5166432 0.0603262
T3:Placebo-T4:CPC+Cy(89) 3.023247e+01 1.24829186 59.2166432 0.0290126
T4:Placebo-T4:CPC+Cy(89) 3.215065e+01 3.16647368 61.1348250 0.0117415
T5:Placebo-T4:CPC+Cy(89) 3.135974e+01 2.37556459 60.3439159 0.0172138
T6:Placebo-T4:CPC+Cy(89) 3.225974e+01 3.27556459 61.2439159 0.0111267
T6:CPC+Cy(89)-T5:CPC+Cy(89) 1.252857e+01 -14.66099544 39.7181383 0.9956926
T0:CY(98)-T5:CPC+Cy(89) 3.220714e+01 5.01757599 59.3967097 0.0038280
T1:CY(98)-T5:CPC+Cy(89) 1.201429e+01 -15.17528116 39.2038526 0.9977211
T2:CY(98)-T5:CPC+Cy(89) 1.492857e+01 -12.26099544 42.1181383 0.9574436
T3:CY(98)-T5:CPC+Cy(89) 1.731429e+01 -9.87528116 44.5038526 0.8222514
T4:CY(98)-T5:CPC+Cy(89) 2.020000e+01 -6.98956687 47.3895669 0.5272783
T5:CY(98)-T5:CPC+Cy(89) 2.258571e+01 -4.60385258 49.7752812 0.2859084
T6:CY(98)-T5:CPC+Cy(89) 2.456429e+01 -2.62528116 51.7538526 0.1469254
T0:Placebo-T5:CPC+Cy(89) 3.220714e+01 3.22296719 61.1913185 0.0114193
T1:Placebo-T5:CPC+Cy(89) 2.477987e+01 -4.20430554 53.7640458 0.2324749
T2:Placebo-T5:CPC+Cy(89) 2.822532e+01 -0.75885099 57.2095003 0.0683415
T3:Placebo-T5:CPC+Cy(89) 2.992532e+01 0.94114901 58.9095003 0.0332825
T4:Placebo-T5:CPC+Cy(89) 3.184351e+01 2.85933082 60.8276822 0.0136434
T5:Placebo-T5:CPC+Cy(89) 3.105260e+01 2.06842173 60.0367731 0.0198997
T6:Placebo-T5:CPC+Cy(89) 3.195260e+01 2.96842173 60.9367731 0.0129379
T0:CY(98)-T6:CPC+Cy(89) 1.967857e+01 -7.51099544 46.8681383 0.5852120
T1:CY(98)-T6:CPC+Cy(89) -5.142857e-01 -27.70385258 26.6752812 1.0000000
T2:CY(98)-T6:CPC+Cy(89) 2.400000e+00 -24.78956687 29.5895669 1.0000000
T3:CY(98)-T6:CPC+Cy(89) 4.785714e+00 -22.40385258 31.9752812 1.0000000
T4:CY(98)-T6:CPC+Cy(89) 7.671429e+00 -19.51813830 34.8609954 0.9999995
T5:CY(98)-T6:CPC+Cy(89) 1.005714e+01 -17.13242401 37.2467097 0.9998904
T6:CY(98)-T6:CPC+Cy(89) 1.203571e+01 -15.15385258 39.2252812 0.9976571
T0:Placebo-T6:CPC+Cy(89) 1.967857e+01 -9.30560424 48.6627471 0.7160907
T1:Placebo-T6:CPC+Cy(89) 1.225130e+01 -16.73287697 41.2354744 0.9988779
T2:Placebo-T6:CPC+Cy(89) 1.569675e+01 -13.28742242 44.6809289 0.9636162
T3:Placebo-T6:CPC+Cy(89) 1.739675e+01 -11.58742242 46.3809289 0.8935375
T4:Placebo-T6:CPC+Cy(89) 1.931494e+01 -9.66924061 48.2991107 0.7499649
T5:Placebo-T6:CPC+Cy(89) 1.852403e+01 -10.46014970 47.5082016 0.8170482
T6:Placebo-T6:CPC+Cy(89) 1.942403e+01 -9.56014970 48.4082016 0.7399793
T1:CY(98)-T0:CY(98) -2.019286e+01 -47.38242401 6.9967097 0.5280702
T2:CY(98)-T0:CY(98) -1.727857e+01 -44.46813830 9.9109954 0.8251753
T3:CY(98)-T0:CY(98) -1.489286e+01 -42.08242401 12.2967097 0.9585784
T4:CY(98)-T0:CY(98) -1.200714e+01 -39.19670973 15.1824240 0.9977421
T5:CY(98)-T0:CY(98) -9.621429e+00 -36.81099544 17.5681383 0.9999523
T6:CY(98)-T0:CY(98) -7.642857e+00 -34.83242401 19.5467097 0.9999996
T0:Placebo-T0:CY(98) 5.684342e-14 -28.98417567 28.9841757 1.0000000
T1:Placebo-T0:CY(98) -7.427273e+00 -36.41144840 21.5569029 0.9999999
T2:Placebo-T0:CY(98) -3.981818e+00 -32.96599385 25.0023575 1.0000000
T3:Placebo-T0:CY(98) -2.281818e+00 -31.26599385 26.7023575 1.0000000
T4:Placebo-T0:CY(98) -3.636364e-01 -29.34781203 28.6205393 1.0000000
T5:Placebo-T0:CY(98) -1.154545e+00 -30.13872112 27.8296302 1.0000000
T6:Placebo-T0:CY(98) -2.545455e-01 -29.23872112 28.7296302 1.0000000
T2:CY(98)-T1:CY(98) 2.914286e+00 -24.27528116 30.1038526 1.0000000
T3:CY(98)-T1:CY(98) 5.300000e+00 -21.88956687 32.4895669 1.0000000
T4:CY(98)-T1:CY(98) 8.185714e+00 -19.00385258 35.3752812 0.9999981
T5:CY(98)-T1:CY(98) 1.057143e+01 -16.61813830 37.7609954 0.9997299
T6:CY(98)-T1:CY(98) 1.255000e+01 -14.63956687 39.7395669 0.9955824
T0:Placebo-T1:CY(98) 2.019286e+01 -8.79131853 49.1770328 0.6656945
T1:Placebo-T1:CY(98) 1.276558e+01 -16.21859125 41.7497601 0.9978341
T2:Placebo-T1:CY(98) 1.621104e+01 -12.77313671 45.1952146 0.9477819
T3:Placebo-T1:CY(98) 1.791104e+01 -11.07313671 46.8952146 0.8616403
T4:Placebo-T1:CY(98) 1.982922e+01 -9.15495489 48.8133964 0.7015981
T5:Placebo-T1:CY(98) 1.903831e+01 -9.94586398 48.0224874 0.7745381
T6:Placebo-T1:CY(98) 1.993831e+01 -9.04586398 48.9224874 0.6909554
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T4:CY(98)-T2:CY(98) 5.271429e+00 -21.91813830 32.4609954 1.0000000
T5:CY(98)-T2:CY(98) 7.657143e+00 -19.53242401 34.8467097 0.9999996
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T0:Placebo-T2:CY(98) 1.727857e+01 -11.70560424 46.2627471 0.9001397
T1:Placebo-T2:CY(98) 9.851299e+00 -19.13287697 38.8354744 0.9999781
T2:Placebo-T2:CY(98) 1.329675e+01 -15.68742242 42.2809289 0.9959655
T3:Placebo-T2:CY(98) 1.499675e+01 -13.98742242 43.9809289 0.9789863
T4:Placebo-T2:CY(98) 1.691494e+01 -12.06924061 45.8991107 0.9187584
T5:Placebo-T2:CY(98) 1.612403e+01 -12.86014970 45.1082016 0.9507621
T6:Placebo-T2:CY(98) 1.702403e+01 -11.96014970 46.0082016 0.9134397
T4:CY(98)-T3:CY(98) 2.885714e+00 -24.30385258 30.0752812 1.0000000
T5:CY(98)-T3:CY(98) 5.271429e+00 -21.91813830 32.4609954 1.0000000
T6:CY(98)-T3:CY(98) 7.250000e+00 -19.93956687 34.4395669 0.9999999
T0:Placebo-T3:CY(98) 1.489286e+01 -14.09131853 43.8770328 0.9807462
T1:Placebo-T3:CY(98) 7.465584e+00 -21.51859125 36.4497601 0.9999999
T2:Placebo-T3:CY(98) 1.091104e+01 -18.07313671 39.8952146 0.9998488
T3:Placebo-T3:CY(98) 1.261104e+01 -16.37313671 41.5952146 0.9982119
T4:Placebo-T3:CY(98) 1.452922e+01 -14.45495489 43.5133964 0.9860053
T5:Placebo-T3:CY(98) 1.373831e+01 -15.24586398 42.7224874 0.9935050
T6:Placebo-T3:CY(98) 1.463831e+01 -14.34586398 43.6224874 0.9845667
T5:CY(98)-T4:CY(98) 2.385714e+00 -24.80385258 29.5752812 1.0000000
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T1:Placebo-T4:CY(98) 4.579870e+00 -24.40430554 33.5640458 1.0000000
T2:Placebo-T4:CY(98) 8.025325e+00 -20.95885099 37.0095003 0.9999997
T3:Placebo-T4:CY(98) 9.725325e+00 -19.25885099 38.7095003 0.9999830
T4:Placebo-T4:CY(98) 1.164351e+01 -17.34066918 40.6276822 0.9995222
T5:Placebo-T4:CY(98) 1.085260e+01 -18.13157827 39.8367731 0.9998629
T6:Placebo-T4:CY(98) 1.175260e+01 -17.23157827 40.7367731 0.9994394
T6:CY(98)-T5:CY(98) 1.978571e+00 -25.21099544 29.1681383 1.0000000
T0:Placebo-T5:CY(98) 9.621429e+00 -19.36274710 38.6056042 0.9999863
T1:Placebo-T5:CY(98) 2.194156e+00 -26.79001983 31.1783315 1.0000000
T2:Placebo-T5:CY(98) 5.639610e+00 -23.34456528 34.6237861 1.0000000
T3:Placebo-T5:CY(98) 7.339610e+00 -21.64456528 36.3237861 1.0000000
T4:Placebo-T5:CY(98) 9.257792e+00 -19.72638346 38.2419679 0.9999937
T5:Placebo-T5:CY(98) 8.466883e+00 -20.51729255 37.4510588 0.9999990
T6:Placebo-T5:CY(98) 9.366883e+00 -19.61729255 38.3510588 0.9999920
T0:Placebo-T6:CY(98) 7.642857e+00 -21.34131853 36.6270328 0.9999999
T1:Placebo-T6:CY(98) 2.155844e-01 -28.76859125 29.1997601 1.0000000
T2:Placebo-T6:CY(98) 3.661039e+00 -25.32313671 32.6452146 1.0000000
T3:Placebo-T6:CY(98) 5.361039e+00 -23.62313671 34.3452146 1.0000000
T4:Placebo-T6:CY(98) 7.279221e+00 -21.70495489 36.2633964 1.0000000
T5:Placebo-T6:CY(98) 6.488312e+00 -22.49586398 35.4724874 1.0000000
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T1:Placebo-T0:Placebo -7.427273e+00 -38.10124104 23.2466956 1.0000000
T2:Placebo-T0:Placebo -3.981818e+00 -34.65578649 26.6921501 1.0000000
T3:Placebo-T0:Placebo -2.281818e+00 -32.95578649 28.3921501 1.0000000
T4:Placebo-T0:Placebo -3.636364e-01 -31.03760468 30.3103319 1.0000000
T5:Placebo-T0:Placebo -1.154545e+00 -31.82851377 29.5194229 1.0000000
T6:Placebo-T0:Placebo -2.545455e-01 -30.92851377 30.4194229 1.0000000
T2:Placebo-T1:Placebo 3.445455e+00 -27.22851377 34.1194229 1.0000000
T3:Placebo-T1:Placebo 5.145455e+00 -25.52851377 35.8194229 1.0000000
T4:Placebo-T1:Placebo 7.063636e+00 -23.61033195 37.7376047 1.0000000
T5:Placebo-T1:Placebo 6.272727e+00 -24.40124104 36.9466956 1.0000000
T6:Placebo-T1:Placebo 7.172727e+00 -23.50124104 37.8466956 1.0000000
T3:Placebo-T2:Placebo 1.700000e+00 -28.97396831 32.3739683 1.0000000
T4:Placebo-T2:Placebo 3.618182e+00 -27.05578649 34.2921501 1.0000000
T5:Placebo-T2:Placebo 2.827273e+00 -27.84669558 33.5012410 1.0000000
T6:Placebo-T2:Placebo 3.727273e+00 -26.94669558 34.4012410 1.0000000
T4:Placebo-T3:Placebo 1.918182e+00 -28.75578649 32.5921501 1.0000000
T5:Placebo-T3:Placebo 1.127273e+00 -29.54669558 31.8012410 1.0000000
T6:Placebo-T3:Placebo 2.027273e+00 -28.64669558 32.7012410 1.0000000
T5:Placebo-T4:Placebo -7.909091e-01 -31.46487740 29.8830592 1.0000000
T6:Placebo-T4:Placebo 1.090909e-01 -30.56487740 30.7830592 1.0000000
T6:Placebo-T5:Placebo 9.000000e-01 -29.77396831 31.5739683 1.0000000#intra colutorios por tiempo mediante placas
aov3 <- lm(Reduccion ~ Tiempo:Colutorio,
data = df)
summary(aov3)
Call:
lm(formula = Reduccion ~ Tiempo:Colutorio, data = df)
Residuals:
Min 1Q Median 3Q Max
-57.493 -9.326 0.000 12.198 65.393
Coefficients: (1 not defined because of singularities)
Estimate Std. Error t value Pr(>|t|)
(Intercept) 99.7455 5.7895 17.229 < 2e-16 ***
TiempoT0:ColutorioCPC (97) 0.2545 7.7365 0.033 0.973772
TiempoT1:ColutorioCPC (97) -50.7597 7.7365 -6.561 1.97e-10 ***
TiempoT2:ColutorioCPC (97) -41.4883 7.7365 -5.363 1.51e-07 ***
TiempoT3:ColutorioCPC (97) -34.8526 7.7365 -4.505 9.12e-06 ***
TiempoT4:ColutorioCPC (97) -29.8955 7.7365 -3.864 0.000133 ***
TiempoT5:ColutorioCPC (97) -21.7383 7.7365 -2.810 0.005241 **
TiempoT6:ColutorioCPC (97) -8.7383 7.7365 -1.129 0.259481
TiempoT0:ColutorioCPC+Cy(89) 0.2545 7.7365 0.033 0.973772
TiempoT1:ColutorioCPC+Cy(89) -50.3669 7.7365 -6.510 2.67e-10 ***
TiempoT2:ColutorioCPC+Cy(89) -44.9312 7.7365 -5.808 1.45e-08 ***
TiempoT3:ColutorioCPC+Cy(89) -36.1240 7.7365 -4.669 4.34e-06 ***
TiempoT4:ColutorioCPC+Cy(89) -32.2597 7.7365 -4.170 3.87e-05 ***
TiempoT5:ColutorioCPC+Cy(89) -31.9526 7.7365 -4.130 4.56e-05 ***
TiempoT6:ColutorioCPC+Cy(89) -19.4240 7.7365 -2.511 0.012509 *
TiempoT0:ColutorioCY(98) 0.2545 7.7365 0.033 0.973772
TiempoT1:ColutorioCY(98) -19.9383 7.7365 -2.577 0.010378 *
TiempoT2:ColutorioCY(98) -17.0240 7.7365 -2.200 0.028439 *
TiempoT3:ColutorioCY(98) -14.6383 7.7365 -1.892 0.059319 .
TiempoT4:ColutorioCY(98) -11.7526 7.7365 -1.519 0.129657
TiempoT5:ColutorioCY(98) -9.3669 7.7365 -1.211 0.226830
TiempoT6:ColutorioCY(98) -7.3883 7.7365 -0.955 0.340254
TiempoT0:ColutorioPlacebo 0.2545 8.1876 0.031 0.975216
TiempoT1:ColutorioPlacebo -7.1727 8.1876 -0.876 0.381615
TiempoT2:ColutorioPlacebo -3.7273 8.1876 -0.455 0.649227
TiempoT3:ColutorioPlacebo -2.0273 8.1876 -0.248 0.804589
TiempoT4:ColutorioPlacebo -0.1091 8.1876 -0.013 0.989377
TiempoT5:ColutorioPlacebo -0.9000 8.1876 -0.110 0.912535
TiempoT6:ColutorioPlacebo NA NA NA NA
---
Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
Residual standard error: 19.2 on 343 degrees of freedom
Multiple R-squared: 0.4481, Adjusted R-squared: 0.4047
F-statistic: 10.31 on 27 and 343 DF, p-value: < 2.2e-16#tukey
TukeyHSD(aov1) Tukey multiple comparisons of means
95% family-wise confidence level
Fit: aov(formula = Reduccion ~ Tiempo + Colutorio + Tiempo * Colutorio, data = df)
$Tiempo
diff lwr upr p adj
T1-T0 -33.722642 -44.7856708 -22.659612 0.0000000
T2-T0 -28.352830 -39.4158595 -17.289801 0.0000000
T3-T0 -23.290566 -34.3535953 -12.227537 0.0000000
T4-T0 -19.800000 -30.8630293 -8.736971 0.0000041
T5-T0 -17.098113 -28.1611425 -6.035084 0.0001295
T6-T0 -9.645283 -20.7083123 1.417746 0.1335349
T2-T1 5.369811 -5.6932180 16.432841 0.7798751
T3-T1 10.432075 -0.6309538 21.495105 0.0791656
T4-T1 13.922642 2.8596122 24.985671 0.0041321
T5-T1 16.624528 5.5614990 27.687558 0.0002264
T6-T1 24.077358 13.0143292 35.140388 0.0000000
T3-T2 5.062264 -6.0007651 16.125293 0.8240110
T4-T2 8.552830 -2.5101991 19.615859 0.2503644
T5-T2 11.254717 0.1916877 22.317746 0.0431881
T6-T2 18.707547 7.6445179 29.770576 0.0000175
T4-T3 3.490566 -7.5724632 14.553595 0.9665176
T5-T3 6.192453 -4.8705764 17.255482 0.6431039
T6-T3 13.645283 2.5822537 24.708312 0.0054097
T5-T4 2.701887 -8.3611425 13.764916 0.9910432
T6-T4 10.154717 -0.9083123 21.217746 0.0958063
T6-T5 7.452830 -3.6101991 18.515859 0.4177653
$Colutorio
diff lwr upr p adj
CPC+Cy(89)-CPC (97) -3.940816 -11.022526 3.140894 0.4773483
CY(98)-CPC (97) 15.337755 8.256045 22.419465 0.0000003
Placebo-CPC (97) 24.790909 17.241781 32.340037 0.0000000
CY(98)-CPC+Cy(89) 19.278571 12.196861 26.360281 0.0000000
Placebo-CPC+Cy(89) 28.731725 21.182597 36.280854 0.0000000
Placebo-CY(98) 9.453154 1.904026 17.002282 0.0073222
$`Tiempo:Colutorio`
diff lwr upr p adj
T1:CPC (97)-T0:CPC (97) -5.101429e+01 -78.20385258 -23.8247188 0.0000000
T2:CPC (97)-T0:CPC (97) -4.174286e+01 -68.93242401 -14.5532903 0.0000072
T3:CPC (97)-T0:CPC (97) -3.510714e+01 -62.29670973 -7.9175760 0.0006738
T4:CPC (97)-T0:CPC (97) -3.015000e+01 -57.33956687 -2.9604331 0.0118032
T5:CPC (97)-T0:CPC (97) -2.199286e+01 -49.18242401 5.1967097 0.3396837
T6:CPC (97)-T0:CPC (97) -8.992857e+00 -36.18242401 18.1967097 0.9999872
T0:CPC+Cy(89)-T0:CPC (97) 0.000000e+00 -27.18956687 27.1895669 1.0000000
T1:CPC+Cy(89)-T0:CPC (97) -5.062143e+01 -77.81099544 -23.4318617 0.0000000
T2:CPC+Cy(89)-T0:CPC (97) -4.518571e+01 -72.37528116 -17.9961474 0.0000005
T3:CPC+Cy(89)-T0:CPC (97) -3.637857e+01 -63.56813830 -9.1890046 0.0002991
T4:CPC+Cy(89)-T0:CPC (97) -3.251429e+01 -59.70385258 -5.3247188 0.0032102
T5:CPC+Cy(89)-T0:CPC (97) -3.220714e+01 -59.39670973 -5.0175760 0.0038280
T6:CPC+Cy(89)-T0:CPC (97) -1.967857e+01 -46.86813830 7.5109954 0.5852120
T0:CY(98)-T0:CPC (97) -1.136868e-13 -27.18956687 27.1895669 1.0000000
T1:CY(98)-T0:CPC (97) -2.019286e+01 -47.38242401 6.9967097 0.5280702
T2:CY(98)-T0:CPC (97) -1.727857e+01 -44.46813830 9.9109954 0.8251753
T3:CY(98)-T0:CPC (97) -1.489286e+01 -42.08242401 12.2967097 0.9585784
T4:CY(98)-T0:CPC (97) -1.200714e+01 -39.19670973 15.1824240 0.9977421
T5:CY(98)-T0:CPC (97) -9.621429e+00 -36.81099544 17.5681383 0.9999523
T6:CY(98)-T0:CPC (97) -7.642857e+00 -34.83242401 19.5467097 0.9999996
T0:Placebo-T0:CPC (97) -5.684342e-14 -28.98417567 28.9841757 1.0000000
T1:Placebo-T0:CPC (97) -7.427273e+00 -36.41144840 21.5569029 0.9999999
T2:Placebo-T0:CPC (97) -3.981818e+00 -32.96599385 25.0023575 1.0000000
T3:Placebo-T0:CPC (97) -2.281818e+00 -31.26599385 26.7023575 1.0000000
T4:Placebo-T0:CPC (97) -3.636364e-01 -29.34781203 28.6205393 1.0000000
T5:Placebo-T0:CPC (97) -1.154545e+00 -30.13872112 27.8296302 1.0000000
T6:Placebo-T0:CPC (97) -2.545455e-01 -29.23872112 28.7296302 1.0000000
T2:CPC (97)-T1:CPC (97) 9.271429e+00 -17.91813830 36.4609954 0.9999767
T3:CPC (97)-T1:CPC (97) 1.590714e+01 -11.28242401 43.0967097 0.9167309
T4:CPC (97)-T1:CPC (97) 2.086429e+01 -6.32528116 48.0538526 0.4545794
T5:CPC (97)-T1:CPC (97) 2.902143e+01 1.83186170 56.2109954 0.0210052
T6:CPC (97)-T1:CPC (97) 4.202143e+01 14.83186170 69.2109954 0.0000059
T0:CPC+Cy(89)-T1:CPC (97) 5.101429e+01 23.82471884 78.2038526 0.0000000
T1:CPC+Cy(89)-T1:CPC (97) 3.928571e-01 -26.79670973 27.5824240 1.0000000
T2:CPC+Cy(89)-T1:CPC (97) 5.828571e+00 -21.36099544 33.0181383 1.0000000
T3:CPC+Cy(89)-T1:CPC (97) 1.463571e+01 -12.55385258 41.8252812 0.9660944
T4:CPC+Cy(89)-T1:CPC (97) 1.850000e+01 -8.68956687 45.6895669 0.7120278
T5:CPC+Cy(89)-T1:CPC (97) 1.880714e+01 -8.38242401 45.9967097 0.6800916
T6:CPC+Cy(89)-T1:CPC (97) 3.133571e+01 4.14614742 58.5252812 0.0062386
T0:CY(98)-T1:CPC (97) 5.101429e+01 23.82471884 78.2038526 0.0000000
T1:CY(98)-T1:CPC (97) 3.082143e+01 3.63186170 58.0109954 0.0082582
T2:CY(98)-T1:CPC (97) 3.373571e+01 6.54614742 60.9252812 0.0015641
T3:CY(98)-T1:CPC (97) 3.612143e+01 8.93186170 63.3109954 0.0003533
T4:CY(98)-T1:CPC (97) 3.900714e+01 11.81757599 66.1967097 0.0000510
T5:CY(98)-T1:CPC (97) 4.139286e+01 14.20329027 68.5824240 0.0000093
T6:CY(98)-T1:CPC (97) 4.337143e+01 16.18186170 70.5609954 0.0000021
T0:Placebo-T1:CPC (97) 5.101429e+01 22.03011004 79.9984614 0.0000001
T1:Placebo-T1:CPC (97) 4.358701e+01 14.60283732 72.5711887 0.0000134
T2:Placebo-T1:CPC (97) 4.703247e+01 18.04829186 76.0166432 0.0000012
T3:Placebo-T1:CPC (97) 4.873247e+01 19.74829186 77.7166432 0.0000003
T4:Placebo-T1:CPC (97) 5.065065e+01 21.66647368 79.6348250 0.0000001
T5:Placebo-T1:CPC (97) 4.985974e+01 20.87556459 78.8439159 0.0000001
T6:Placebo-T1:CPC (97) 5.075974e+01 21.77556459 79.7439159 0.0000001
T3:CPC (97)-T2:CPC (97) 6.635714e+00 -20.55385258 33.8252812 1.0000000
T4:CPC (97)-T2:CPC (97) 1.159286e+01 -15.59670973 38.7824240 0.9987078
T5:CPC (97)-T2:CPC (97) 1.975000e+01 -7.43956687 46.9395669 0.5772816
T6:CPC (97)-T2:CPC (97) 3.275000e+01 5.56043313 59.9395669 0.0028009
T0:CPC+Cy(89)-T2:CPC (97) 4.174286e+01 14.55329027 68.9324240 0.0000072
T1:CPC+Cy(89)-T2:CPC (97) -8.878571e+00 -36.06813830 18.3109954 0.9999901
T2:CPC+Cy(89)-T2:CPC (97) -3.442857e+00 -30.63242401 23.7467097 1.0000000
T3:CPC+Cy(89)-T2:CPC (97) 5.364286e+00 -21.82528116 32.5538526 1.0000000
T4:CPC+Cy(89)-T2:CPC (97) 9.228571e+00 -17.96099544 36.4181383 0.9999787
T5:CPC+Cy(89)-T2:CPC (97) 9.535714e+00 -17.65385258 36.7252812 0.9999598
T6:CPC+Cy(89)-T2:CPC (97) 2.206429e+01 -5.12528116 49.2538526 0.3329335
T0:CY(98)-T2:CPC (97) 4.174286e+01 14.55329027 68.9324240 0.0000072
T1:CY(98)-T2:CPC (97) 2.155000e+01 -5.63956687 48.7395669 0.3830496
T2:CY(98)-T2:CPC (97) 2.446429e+01 -2.72528116 51.6538526 0.1524392
T3:CY(98)-T2:CPC (97) 2.685000e+01 -0.33956687 54.0395669 0.0581412
T4:CY(98)-T2:CPC (97) 2.973571e+01 2.54614742 56.9252812 0.0146364
T5:CY(98)-T2:CPC (97) 3.212143e+01 4.93186170 59.3109954 0.0040193
T6:CY(98)-T2:CPC (97) 3.410000e+01 6.91043313 61.2895669 0.0012550
T0:Placebo-T2:CPC (97) 4.174286e+01 12.75868147 70.7270328 0.0000459
T1:Placebo-T2:CPC (97) 3.431558e+01 5.33140875 63.2997601 0.0038636
T2:Placebo-T2:CPC (97) 3.776104e+01 8.77686329 66.7452146 0.0005522
T3:Placebo-T2:CPC (97) 3.946104e+01 10.47686329 68.4452146 0.0001967
T4:Placebo-T2:CPC (97) 4.137922e+01 12.39504511 70.3633964 0.0000582
T5:Placebo-T2:CPC (97) 4.058831e+01 11.60413602 69.5724874 0.0000968
T6:Placebo-T2:CPC (97) 4.148831e+01 12.50413602 70.4724874 0.0000542
T4:CPC (97)-T3:CPC (97) 4.957143e+00 -22.23242401 32.1467097 1.0000000
T5:CPC (97)-T3:CPC (97) 1.311429e+01 -14.07528116 40.3038526 0.9916964
T6:CPC (97)-T3:CPC (97) 2.611429e+01 -1.07528116 53.3038526 0.0797134
T0:CPC+Cy(89)-T3:CPC (97) 3.510714e+01 7.91757599 62.2967097 0.0006738
T1:CPC+Cy(89)-T3:CPC (97) -1.551429e+01 -42.70385258 11.6752812 0.9354037
T2:CPC+Cy(89)-T3:CPC (97) -1.007857e+01 -37.26813830 17.1109954 0.9998860
T3:CPC+Cy(89)-T3:CPC (97) -1.271429e+00 -28.46099544 25.9181383 1.0000000
T4:CPC+Cy(89)-T3:CPC (97) 2.592857e+00 -24.59670973 29.7824240 1.0000000
T5:CPC+Cy(89)-T3:CPC (97) 2.900000e+00 -24.28956687 30.0895669 1.0000000
T6:CPC+Cy(89)-T3:CPC (97) 1.542857e+01 -11.76099544 42.6181383 0.9390499
T0:CY(98)-T3:CPC (97) 3.510714e+01 7.91757599 62.2967097 0.0006738
T1:CY(98)-T3:CPC (97) 1.491429e+01 -12.27528116 42.1038526 0.9579002
T2:CY(98)-T3:CPC (97) 1.782857e+01 -9.36099544 45.0181383 0.7773932
T3:CY(98)-T3:CPC (97) 2.021429e+01 -6.97528116 47.4038526 0.5256949
T4:CY(98)-T3:CPC (97) 2.310000e+01 -4.08956687 50.2895669 0.2436578
T5:CY(98)-T3:CPC (97) 2.548571e+01 -1.70385258 52.6752812 0.1030675
T6:CY(98)-T3:CPC (97) 2.746429e+01 0.27471884 54.6538526 0.0441521
T0:Placebo-T3:CPC (97) 3.510714e+01 6.12296719 64.0913185 0.0025169
T1:Placebo-T3:CPC (97) 2.767987e+01 -1.30430554 56.6640458 0.0847848
T2:Placebo-T3:CPC (97) 3.112532e+01 2.14114901 60.1095003 0.0192316
T3:Placebo-T3:CPC (97) 3.282532e+01 3.84114901 61.8095003 0.0083863
T4:Placebo-T3:CPC (97) 3.474351e+01 5.75933082 63.7276822 0.0030689
T5:Placebo-T3:CPC (97) 3.395260e+01 4.96842173 62.9367731 0.0046846
T6:Placebo-T3:CPC (97) 3.485260e+01 5.86842173 63.8367731 0.0028924
T5:CPC (97)-T4:CPC (97) 8.157143e+00 -19.03242401 35.3467097 0.9999983
T6:CPC (97)-T4:CPC (97) 2.115714e+01 -6.03242401 48.3467097 0.4234683
T0:CPC+Cy(89)-T4:CPC (97) 3.015000e+01 2.96043313 57.3395669 0.0118032
T1:CPC+Cy(89)-T4:CPC (97) -2.047143e+01 -47.66099544 6.7181383 0.4973074
T2:CPC+Cy(89)-T4:CPC (97) -1.503571e+01 -42.22528116 12.1538526 0.9539006
T3:CPC+Cy(89)-T4:CPC (97) -6.228571e+00 -33.41813830 20.9609954 1.0000000
T4:CPC+Cy(89)-T4:CPC (97) -2.364286e+00 -29.55385258 24.8252812 1.0000000
T5:CPC+Cy(89)-T4:CPC (97) -2.057143e+00 -29.24670973 25.1324240 1.0000000
T6:CPC+Cy(89)-T4:CPC (97) 1.047143e+01 -16.71813830 37.6609954 0.9997719
T0:CY(98)-T4:CPC (97) 3.015000e+01 2.96043313 57.3395669 0.0118032
T1:CY(98)-T4:CPC (97) 9.957143e+00 -17.23242401 37.1467097 0.9999089
T2:CY(98)-T4:CPC (97) 1.287143e+01 -14.31813830 40.0609954 0.9936210
T3:CY(98)-T4:CPC (97) 1.525714e+01 -11.93242401 42.4467097 0.9458992
T4:CY(98)-T4:CPC (97) 1.814286e+01 -9.04670973 45.3324240 0.7476528
T5:CY(98)-T4:CPC (97) 2.052857e+01 -6.66099544 47.7181383 0.4910363
T6:CY(98)-T4:CPC (97) 2.250714e+01 -4.68242401 49.6967097 0.2927321
T0:Placebo-T4:CPC (97) 3.015000e+01 1.16582433 59.1341757 0.0301085
T1:Placebo-T4:CPC (97) 2.272273e+01 -6.26144840 51.7069029 0.4069458
T2:Placebo-T4:CPC (97) 2.616818e+01 -2.81599385 55.1523575 0.1478167
T3:Placebo-T4:CPC (97) 2.786818e+01 -1.11599385 56.8523575 0.0787718
T4:Placebo-T4:CPC (97) 2.978636e+01 0.80218797 58.7705393 0.0353903
T5:Placebo-T4:CPC (97) 2.899545e+01 0.01127888 57.9796302 0.0497630
T6:Placebo-T4:CPC (97) 2.989545e+01 0.91127888 58.8796302 0.0337260
T6:CPC (97)-T5:CPC (97) 1.300000e+01 -14.18956687 40.1895669 0.9926546
T0:CPC+Cy(89)-T5:CPC (97) 2.199286e+01 -5.19670973 49.1824240 0.3396837
T1:CPC+Cy(89)-T5:CPC (97) -2.862857e+01 -55.81813830 -1.4390046 0.0254851
T2:CPC+Cy(89)-T5:CPC (97) -2.319286e+01 -50.38242401 3.9967097 0.2364848
T3:CPC+Cy(89)-T5:CPC (97) -1.438571e+01 -41.57528116 12.8038526 0.9723620
T4:CPC+Cy(89)-T5:CPC (97) -1.052143e+01 -37.71099544 16.6681383 0.9997517
T5:CPC+Cy(89)-T5:CPC (97) -1.021429e+01 -37.40385258 16.9752812 0.9998544
T6:CPC+Cy(89)-T5:CPC (97) 2.314286e+00 -24.87528116 29.5038526 1.0000000
T0:CY(98)-T5:CPC (97) 2.199286e+01 -5.19670973 49.1824240 0.3396837
T1:CY(98)-T5:CPC (97) 1.800000e+00 -25.38956687 28.9895669 1.0000000
T2:CY(98)-T5:CPC (97) 4.714286e+00 -22.47528116 31.9038526 1.0000000
T3:CY(98)-T5:CPC (97) 7.100000e+00 -20.08956687 34.2895669 0.9999999
T4:CY(98)-T5:CPC (97) 9.985714e+00 -17.20385258 37.1752812 0.9999040
T5:CY(98)-T5:CPC (97) 1.237143e+01 -14.81813830 39.5609954 0.9964319
T6:CY(98)-T5:CPC (97) 1.435000e+01 -12.83956687 41.5395669 0.9731789
T0:Placebo-T5:CPC (97) 2.199286e+01 -6.99131853 50.9770328 0.4798243
T1:Placebo-T5:CPC (97) 1.456558e+01 -14.41859125 43.5497601 0.9855383
T2:Placebo-T5:CPC (97) 1.801104e+01 -10.97313671 46.9952146 0.8548446
T3:Placebo-T5:CPC (97) 1.971104e+01 -9.27313671 48.6952146 0.7129883
T4:Placebo-T5:CPC (97) 2.162922e+01 -7.35495489 50.6133964 0.5173115
T5:Placebo-T5:CPC (97) 2.083831e+01 -8.14586398 49.8224874 0.5996707
T6:Placebo-T5:CPC (97) 2.173831e+01 -7.24586398 50.7224874 0.5060114
T0:CPC+Cy(89)-T6:CPC (97) 8.992857e+00 -18.19670973 36.1824240 0.9999872
T1:CPC+Cy(89)-T6:CPC (97) -4.162857e+01 -68.81813830 -14.4390046 0.0000078
T2:CPC+Cy(89)-T6:CPC (97) -3.619286e+01 -63.38242401 -9.0032903 0.0003374
T3:CPC+Cy(89)-T6:CPC (97) -2.738571e+01 -54.57528116 -0.1961474 0.0457608
T4:CPC+Cy(89)-T6:CPC (97) -2.352143e+01 -50.71099544 3.6681383 0.2122393
T5:CPC+Cy(89)-T6:CPC (97) -2.321429e+01 -50.40385258 3.9752812 0.2348495
T6:CPC+Cy(89)-T6:CPC (97) -1.068571e+01 -37.87528116 16.5038526 0.9996735
T0:CY(98)-T6:CPC (97) 8.992857e+00 -18.19670973 36.1824240 0.9999872
T1:CY(98)-T6:CPC (97) -1.120000e+01 -38.38956687 15.9895669 0.9992682
T2:CY(98)-T6:CPC (97) -8.285714e+00 -35.47528116 18.9038526 0.9999976
T3:CY(98)-T6:CPC (97) -5.900000e+00 -33.08956687 21.2895669 1.0000000
T4:CY(98)-T6:CPC (97) -3.014286e+00 -30.20385258 24.1752812 1.0000000
T5:CY(98)-T6:CPC (97) -6.285714e-01 -27.81813830 26.5609954 1.0000000
T6:CY(98)-T6:CPC (97) 1.350000e+00 -25.83956687 28.5395669 1.0000000
T0:Placebo-T6:CPC (97) 8.992857e+00 -19.99131853 37.9770328 0.9999965
T1:Placebo-T6:CPC (97) 1.565584e+00 -27.41859125 30.5497601 1.0000000
T2:Placebo-T6:CPC (97) 5.011039e+00 -23.97313671 33.9952146 1.0000000
T3:Placebo-T6:CPC (97) 6.711039e+00 -22.27313671 35.6952146 1.0000000
T4:Placebo-T6:CPC (97) 8.629221e+00 -20.35495489 37.6133964 0.9999985
T5:Placebo-T6:CPC (97) 7.838312e+00 -21.14586398 36.8224874 0.9999998
T6:Placebo-T6:CPC (97) 8.738312e+00 -20.24586398 37.7224874 0.9999981
T1:CPC+Cy(89)-T0:CPC+Cy(89) -5.062143e+01 -77.81099544 -23.4318617 0.0000000
T2:CPC+Cy(89)-T0:CPC+Cy(89) -4.518571e+01 -72.37528116 -17.9961474 0.0000005
T3:CPC+Cy(89)-T0:CPC+Cy(89) -3.637857e+01 -63.56813830 -9.1890046 0.0002991
T4:CPC+Cy(89)-T0:CPC+Cy(89) -3.251429e+01 -59.70385258 -5.3247188 0.0032102
T5:CPC+Cy(89)-T0:CPC+Cy(89) -3.220714e+01 -59.39670973 -5.0175760 0.0038280
T6:CPC+Cy(89)-T0:CPC+Cy(89) -1.967857e+01 -46.86813830 7.5109954 0.5852120
T0:CY(98)-T0:CPC+Cy(89) -1.136868e-13 -27.18956687 27.1895669 1.0000000
T1:CY(98)-T0:CPC+Cy(89) -2.019286e+01 -47.38242401 6.9967097 0.5280702
T2:CY(98)-T0:CPC+Cy(89) -1.727857e+01 -44.46813830 9.9109954 0.8251753
T3:CY(98)-T0:CPC+Cy(89) -1.489286e+01 -42.08242401 12.2967097 0.9585784
T4:CY(98)-T0:CPC+Cy(89) -1.200714e+01 -39.19670973 15.1824240 0.9977421
T5:CY(98)-T0:CPC+Cy(89) -9.621429e+00 -36.81099544 17.5681383 0.9999523
T6:CY(98)-T0:CPC+Cy(89) -7.642857e+00 -34.83242401 19.5467097 0.9999996
T0:Placebo-T0:CPC+Cy(89) -5.684342e-14 -28.98417567 28.9841757 1.0000000
T1:Placebo-T0:CPC+Cy(89) -7.427273e+00 -36.41144840 21.5569029 0.9999999
T2:Placebo-T0:CPC+Cy(89) -3.981818e+00 -32.96599385 25.0023575 1.0000000
T3:Placebo-T0:CPC+Cy(89) -2.281818e+00 -31.26599385 26.7023575 1.0000000
T4:Placebo-T0:CPC+Cy(89) -3.636364e-01 -29.34781203 28.6205393 1.0000000
T5:Placebo-T0:CPC+Cy(89) -1.154545e+00 -30.13872112 27.8296302 1.0000000
T6:Placebo-T0:CPC+Cy(89) -2.545455e-01 -29.23872112 28.7296302 1.0000000
T2:CPC+Cy(89)-T1:CPC+Cy(89) 5.435714e+00 -21.75385258 32.6252812 1.0000000
T3:CPC+Cy(89)-T1:CPC+Cy(89) 1.424286e+01 -12.94670973 41.4324240 0.9755179
T4:CPC+Cy(89)-T1:CPC+Cy(89) 1.810714e+01 -9.08242401 45.2967097 0.7511130
T5:CPC+Cy(89)-T1:CPC+Cy(89) 1.841429e+01 -8.77528116 45.6038526 0.7207383
T6:CPC+Cy(89)-T1:CPC+Cy(89) 3.094286e+01 3.75329027 58.1324240 0.0077332
T0:CY(98)-T1:CPC+Cy(89) 5.062143e+01 23.43186170 77.8109954 0.0000000
T1:CY(98)-T1:CPC+Cy(89) 3.042857e+01 3.23900456 57.6181383 0.0101904
T2:CY(98)-T1:CPC+Cy(89) 3.334286e+01 6.15329027 60.5324240 0.0019776
T3:CY(98)-T1:CPC+Cy(89) 3.572857e+01 8.53900456 62.9181383 0.0004547
T4:CY(98)-T1:CPC+Cy(89) 3.861429e+01 11.42471884 65.8038526 0.0000670
T5:CY(98)-T1:CPC+Cy(89) 4.100000e+01 13.81043313 68.1895669 0.0000124
T6:CY(98)-T1:CPC+Cy(89) 4.297857e+01 15.78900456 70.1681383 0.0000029
T0:Placebo-T1:CPC+Cy(89) 5.062143e+01 21.63725290 79.6056042 0.0000001
T1:Placebo-T1:CPC+Cy(89) 4.319416e+01 14.20998017 72.1783315 0.0000175
T2:Placebo-T1:CPC+Cy(89) 4.663961e+01 17.65543472 75.6237861 0.0000016
T3:Placebo-T1:CPC+Cy(89) 4.833961e+01 19.35543472 77.3237861 0.0000005
T4:Placebo-T1:CPC+Cy(89) 5.025779e+01 21.27361654 79.2419679 0.0000001
T5:Placebo-T1:CPC+Cy(89) 4.946688e+01 20.48270745 78.4510588 0.0000002
T6:Placebo-T1:CPC+Cy(89) 5.036688e+01 21.38270745 79.3510588 0.0000001
T3:CPC+Cy(89)-T2:CPC+Cy(89) 8.807143e+00 -18.38242401 35.9967097 0.9999916
T4:CPC+Cy(89)-T2:CPC+Cy(89) 1.267143e+01 -14.51813830 39.8609954 0.9949118
T5:CPC+Cy(89)-T2:CPC+Cy(89) 1.297857e+01 -14.21099544 40.1681383 0.9928237
T6:CPC+Cy(89)-T2:CPC+Cy(89) 2.550714e+01 -1.68242401 52.6967097 0.1021888
T0:CY(98)-T2:CPC+Cy(89) 4.518571e+01 17.99614742 72.3752812 0.0000005
T1:CY(98)-T2:CPC+Cy(89) 2.499286e+01 -2.19670973 52.1824240 0.1250071
T2:CY(98)-T2:CPC+Cy(89) 2.790714e+01 0.71757599 55.0967097 0.0359750
T3:CY(98)-T2:CPC+Cy(89) 3.029286e+01 3.10329027 57.4824240 0.0109490
T4:CY(98)-T2:CPC+Cy(89) 3.317857e+01 5.98900456 60.3681383 0.0021794
T5:CY(98)-T2:CPC+Cy(89) 3.556429e+01 8.37471884 62.7538526 0.0005049
T6:CY(98)-T2:CPC+Cy(89) 3.754286e+01 10.35329027 64.7324240 0.0001387
T0:Placebo-T2:CPC+Cy(89) 4.518571e+01 16.20153862 74.1698900 0.0000045
T1:Placebo-T2:CPC+Cy(89) 3.775844e+01 8.77426589 66.7426172 0.0005530
T2:Placebo-T2:CPC+Cy(89) 4.120390e+01 12.21972043 70.1880718 0.0000652
T3:Placebo-T2:CPC+Cy(89) 4.290390e+01 13.91972043 71.8880718 0.0000213
T4:Placebo-T2:CPC+Cy(89) 4.482208e+01 15.83790225 73.8062536 0.0000057
T5:Placebo-T2:CPC+Cy(89) 4.403117e+01 15.04699316 73.0153445 0.0000099
T6:Placebo-T2:CPC+Cy(89) 4.493117e+01 15.94699316 73.9153445 0.0000053
T4:CPC+Cy(89)-T3:CPC+Cy(89) 3.864286e+00 -23.32528116 31.0538526 1.0000000
T5:CPC+Cy(89)-T3:CPC+Cy(89) 4.171429e+00 -23.01813830 31.3609954 1.0000000
T6:CPC+Cy(89)-T3:CPC+Cy(89) 1.670000e+01 -10.48956687 43.8895669 0.8688148
T0:CY(98)-T3:CPC+Cy(89) 3.637857e+01 9.18900456 63.5681383 0.0002991
T1:CY(98)-T3:CPC+Cy(89) 1.618571e+01 -11.00385258 43.3752812 0.9014767
T2:CY(98)-T3:CPC+Cy(89) 1.910000e+01 -8.08956687 46.2895669 0.6487588
T3:CY(98)-T3:CPC+Cy(89) 2.148571e+01 -5.70385258 48.6752812 0.3895474
T4:CY(98)-T3:CPC+Cy(89) 2.437143e+01 -2.81813830 51.5609954 0.1576978
T5:CY(98)-T3:CPC+Cy(89) 2.675714e+01 -0.43242401 53.9467097 0.0605555
T6:CY(98)-T3:CPC+Cy(89) 2.873571e+01 1.54614742 55.9252812 0.0241855
T0:Placebo-T3:CPC+Cy(89) 3.637857e+01 7.39439576 65.3627471 0.0012352
T1:Placebo-T3:CPC+Cy(89) 2.895130e+01 -0.03287697 57.9354744 0.0506965
T2:Placebo-T3:CPC+Cy(89) 3.239675e+01 3.41257758 61.3809289 0.0103962
T3:Placebo-T3:CPC+Cy(89) 3.409675e+01 5.11257758 63.0809289 0.0043408
T4:Placebo-T3:CPC+Cy(89) 3.601494e+01 7.03075939 64.9991107 0.0015185
T5:Placebo-T3:CPC+Cy(89) 3.522403e+01 6.23985030 64.2082016 0.0023603
T6:Placebo-T3:CPC+Cy(89) 3.612403e+01 7.13985030 65.1082016 0.0014276
T5:CPC+Cy(89)-T4:CPC+Cy(89) 3.071429e-01 -26.88242401 27.4967097 1.0000000
T6:CPC+Cy(89)-T4:CPC+Cy(89) 1.283571e+01 -14.35385258 40.0252812 0.9938697
T0:CY(98)-T4:CPC+Cy(89) 3.251429e+01 5.32471884 59.7038526 0.0032102
T1:CY(98)-T4:CPC+Cy(89) 1.232143e+01 -14.86813830 39.5109954 0.9966432
T2:CY(98)-T4:CPC+Cy(89) 1.523571e+01 -11.95385258 42.4252812 0.9467146
T3:CY(98)-T4:CPC+Cy(89) 1.762143e+01 -9.56813830 44.8109954 0.7960620
T4:CY(98)-T4:CPC+Cy(89) 2.050714e+01 -6.68242401 47.6967097 0.4933861
T5:CY(98)-T4:CPC+Cy(89) 2.289286e+01 -4.29670973 50.0824240 0.2601651
T6:CY(98)-T4:CPC+Cy(89) 2.487143e+01 -2.31813830 52.0609954 0.1309405
T0:Placebo-T4:CPC+Cy(89) 3.251429e+01 3.53011004 61.4984614 0.0098050
T1:Placebo-T4:CPC+Cy(89) 2.508701e+01 -3.89716268 54.0711887 0.2113679
T2:Placebo-T4:CPC+Cy(89) 2.853247e+01 -0.45170814 57.5166432 0.0603262
T3:Placebo-T4:CPC+Cy(89) 3.023247e+01 1.24829186 59.2166432 0.0290126
T4:Placebo-T4:CPC+Cy(89) 3.215065e+01 3.16647368 61.1348250 0.0117415
T5:Placebo-T4:CPC+Cy(89) 3.135974e+01 2.37556459 60.3439159 0.0172138
T6:Placebo-T4:CPC+Cy(89) 3.225974e+01 3.27556459 61.2439159 0.0111267
T6:CPC+Cy(89)-T5:CPC+Cy(89) 1.252857e+01 -14.66099544 39.7181383 0.9956926
T0:CY(98)-T5:CPC+Cy(89) 3.220714e+01 5.01757599 59.3967097 0.0038280
T1:CY(98)-T5:CPC+Cy(89) 1.201429e+01 -15.17528116 39.2038526 0.9977211
T2:CY(98)-T5:CPC+Cy(89) 1.492857e+01 -12.26099544 42.1181383 0.9574436
T3:CY(98)-T5:CPC+Cy(89) 1.731429e+01 -9.87528116 44.5038526 0.8222514
T4:CY(98)-T5:CPC+Cy(89) 2.020000e+01 -6.98956687 47.3895669 0.5272783
T5:CY(98)-T5:CPC+Cy(89) 2.258571e+01 -4.60385258 49.7752812 0.2859084
T6:CY(98)-T5:CPC+Cy(89) 2.456429e+01 -2.62528116 51.7538526 0.1469254
T0:Placebo-T5:CPC+Cy(89) 3.220714e+01 3.22296719 61.1913185 0.0114193
T1:Placebo-T5:CPC+Cy(89) 2.477987e+01 -4.20430554 53.7640458 0.2324749
T2:Placebo-T5:CPC+Cy(89) 2.822532e+01 -0.75885099 57.2095003 0.0683415
T3:Placebo-T5:CPC+Cy(89) 2.992532e+01 0.94114901 58.9095003 0.0332825
T4:Placebo-T5:CPC+Cy(89) 3.184351e+01 2.85933082 60.8276822 0.0136434
T5:Placebo-T5:CPC+Cy(89) 3.105260e+01 2.06842173 60.0367731 0.0198997
T6:Placebo-T5:CPC+Cy(89) 3.195260e+01 2.96842173 60.9367731 0.0129379
T0:CY(98)-T6:CPC+Cy(89) 1.967857e+01 -7.51099544 46.8681383 0.5852120
T1:CY(98)-T6:CPC+Cy(89) -5.142857e-01 -27.70385258 26.6752812 1.0000000
T2:CY(98)-T6:CPC+Cy(89) 2.400000e+00 -24.78956687 29.5895669 1.0000000
T3:CY(98)-T6:CPC+Cy(89) 4.785714e+00 -22.40385258 31.9752812 1.0000000
T4:CY(98)-T6:CPC+Cy(89) 7.671429e+00 -19.51813830 34.8609954 0.9999995
T5:CY(98)-T6:CPC+Cy(89) 1.005714e+01 -17.13242401 37.2467097 0.9998904
T6:CY(98)-T6:CPC+Cy(89) 1.203571e+01 -15.15385258 39.2252812 0.9976571
T0:Placebo-T6:CPC+Cy(89) 1.967857e+01 -9.30560424 48.6627471 0.7160907
T1:Placebo-T6:CPC+Cy(89) 1.225130e+01 -16.73287697 41.2354744 0.9988779
T2:Placebo-T6:CPC+Cy(89) 1.569675e+01 -13.28742242 44.6809289 0.9636162
T3:Placebo-T6:CPC+Cy(89) 1.739675e+01 -11.58742242 46.3809289 0.8935375
T4:Placebo-T6:CPC+Cy(89) 1.931494e+01 -9.66924061 48.2991107 0.7499649
T5:Placebo-T6:CPC+Cy(89) 1.852403e+01 -10.46014970 47.5082016 0.8170482
T6:Placebo-T6:CPC+Cy(89) 1.942403e+01 -9.56014970 48.4082016 0.7399793
T1:CY(98)-T0:CY(98) -2.019286e+01 -47.38242401 6.9967097 0.5280702
T2:CY(98)-T0:CY(98) -1.727857e+01 -44.46813830 9.9109954 0.8251753
T3:CY(98)-T0:CY(98) -1.489286e+01 -42.08242401 12.2967097 0.9585784
T4:CY(98)-T0:CY(98) -1.200714e+01 -39.19670973 15.1824240 0.9977421
T5:CY(98)-T0:CY(98) -9.621429e+00 -36.81099544 17.5681383 0.9999523
T6:CY(98)-T0:CY(98) -7.642857e+00 -34.83242401 19.5467097 0.9999996
T0:Placebo-T0:CY(98) 5.684342e-14 -28.98417567 28.9841757 1.0000000
T1:Placebo-T0:CY(98) -7.427273e+00 -36.41144840 21.5569029 0.9999999
T2:Placebo-T0:CY(98) -3.981818e+00 -32.96599385 25.0023575 1.0000000
T3:Placebo-T0:CY(98) -2.281818e+00 -31.26599385 26.7023575 1.0000000
T4:Placebo-T0:CY(98) -3.636364e-01 -29.34781203 28.6205393 1.0000000
T5:Placebo-T0:CY(98) -1.154545e+00 -30.13872112 27.8296302 1.0000000
T6:Placebo-T0:CY(98) -2.545455e-01 -29.23872112 28.7296302 1.0000000
T2:CY(98)-T1:CY(98) 2.914286e+00 -24.27528116 30.1038526 1.0000000
T3:CY(98)-T1:CY(98) 5.300000e+00 -21.88956687 32.4895669 1.0000000
T4:CY(98)-T1:CY(98) 8.185714e+00 -19.00385258 35.3752812 0.9999981
T5:CY(98)-T1:CY(98) 1.057143e+01 -16.61813830 37.7609954 0.9997299
T6:CY(98)-T1:CY(98) 1.255000e+01 -14.63956687 39.7395669 0.9955824
T0:Placebo-T1:CY(98) 2.019286e+01 -8.79131853 49.1770328 0.6656945
T1:Placebo-T1:CY(98) 1.276558e+01 -16.21859125 41.7497601 0.9978341
T2:Placebo-T1:CY(98) 1.621104e+01 -12.77313671 45.1952146 0.9477819
T3:Placebo-T1:CY(98) 1.791104e+01 -11.07313671 46.8952146 0.8616403
T4:Placebo-T1:CY(98) 1.982922e+01 -9.15495489 48.8133964 0.7015981
T5:Placebo-T1:CY(98) 1.903831e+01 -9.94586398 48.0224874 0.7745381
T6:Placebo-T1:CY(98) 1.993831e+01 -9.04586398 48.9224874 0.6909554
T3:CY(98)-T2:CY(98) 2.385714e+00 -24.80385258 29.5752812 1.0000000
T4:CY(98)-T2:CY(98) 5.271429e+00 -21.91813830 32.4609954 1.0000000
T5:CY(98)-T2:CY(98) 7.657143e+00 -19.53242401 34.8467097 0.9999996
T6:CY(98)-T2:CY(98) 9.635714e+00 -17.55385258 36.8252812 0.9999509
T0:Placebo-T2:CY(98) 1.727857e+01 -11.70560424 46.2627471 0.9001397
T1:Placebo-T2:CY(98) 9.851299e+00 -19.13287697 38.8354744 0.9999781
T2:Placebo-T2:CY(98) 1.329675e+01 -15.68742242 42.2809289 0.9959655
T3:Placebo-T2:CY(98) 1.499675e+01 -13.98742242 43.9809289 0.9789863
T4:Placebo-T2:CY(98) 1.691494e+01 -12.06924061 45.8991107 0.9187584
T5:Placebo-T2:CY(98) 1.612403e+01 -12.86014970 45.1082016 0.9507621
T6:Placebo-T2:CY(98) 1.702403e+01 -11.96014970 46.0082016 0.9134397
T4:CY(98)-T3:CY(98) 2.885714e+00 -24.30385258 30.0752812 1.0000000
T5:CY(98)-T3:CY(98) 5.271429e+00 -21.91813830 32.4609954 1.0000000
T6:CY(98)-T3:CY(98) 7.250000e+00 -19.93956687 34.4395669 0.9999999
T0:Placebo-T3:CY(98) 1.489286e+01 -14.09131853 43.8770328 0.9807462
T1:Placebo-T3:CY(98) 7.465584e+00 -21.51859125 36.4497601 0.9999999
T2:Placebo-T3:CY(98) 1.091104e+01 -18.07313671 39.8952146 0.9998488
T3:Placebo-T3:CY(98) 1.261104e+01 -16.37313671 41.5952146 0.9982119
T4:Placebo-T3:CY(98) 1.452922e+01 -14.45495489 43.5133964 0.9860053
T5:Placebo-T3:CY(98) 1.373831e+01 -15.24586398 42.7224874 0.9935050
T6:Placebo-T3:CY(98) 1.463831e+01 -14.34586398 43.6224874 0.9845667
T5:CY(98)-T4:CY(98) 2.385714e+00 -24.80385258 29.5752812 1.0000000
T6:CY(98)-T4:CY(98) 4.364286e+00 -22.82528116 31.5538526 1.0000000
T0:Placebo-T4:CY(98) 1.200714e+01 -16.97703281 40.9913185 0.9991954
T1:Placebo-T4:CY(98) 4.579870e+00 -24.40430554 33.5640458 1.0000000
T2:Placebo-T4:CY(98) 8.025325e+00 -20.95885099 37.0095003 0.9999997
T3:Placebo-T4:CY(98) 9.725325e+00 -19.25885099 38.7095003 0.9999830
T4:Placebo-T4:CY(98) 1.164351e+01 -17.34066918 40.6276822 0.9995222
T5:Placebo-T4:CY(98) 1.085260e+01 -18.13157827 39.8367731 0.9998629
T6:Placebo-T4:CY(98) 1.175260e+01 -17.23157827 40.7367731 0.9994394
T6:CY(98)-T5:CY(98) 1.978571e+00 -25.21099544 29.1681383 1.0000000
T0:Placebo-T5:CY(98) 9.621429e+00 -19.36274710 38.6056042 0.9999863
T1:Placebo-T5:CY(98) 2.194156e+00 -26.79001983 31.1783315 1.0000000
T2:Placebo-T5:CY(98) 5.639610e+00 -23.34456528 34.6237861 1.0000000
T3:Placebo-T5:CY(98) 7.339610e+00 -21.64456528 36.3237861 1.0000000
T4:Placebo-T5:CY(98) 9.257792e+00 -19.72638346 38.2419679 0.9999937
T5:Placebo-T5:CY(98) 8.466883e+00 -20.51729255 37.4510588 0.9999990
T6:Placebo-T5:CY(98) 9.366883e+00 -19.61729255 38.3510588 0.9999920
T0:Placebo-T6:CY(98) 7.642857e+00 -21.34131853 36.6270328 0.9999999
T1:Placebo-T6:CY(98) 2.155844e-01 -28.76859125 29.1997601 1.0000000
T2:Placebo-T6:CY(98) 3.661039e+00 -25.32313671 32.6452146 1.0000000
T3:Placebo-T6:CY(98) 5.361039e+00 -23.62313671 34.3452146 1.0000000
T4:Placebo-T6:CY(98) 7.279221e+00 -21.70495489 36.2633964 1.0000000
T5:Placebo-T6:CY(98) 6.488312e+00 -22.49586398 35.4724874 1.0000000
T6:Placebo-T6:CY(98) 7.388312e+00 -21.59586398 36.3724874 1.0000000
T1:Placebo-T0:Placebo -7.427273e+00 -38.10124104 23.2466956 1.0000000
T2:Placebo-T0:Placebo -3.981818e+00 -34.65578649 26.6921501 1.0000000
T3:Placebo-T0:Placebo -2.281818e+00 -32.95578649 28.3921501 1.0000000
T4:Placebo-T0:Placebo -3.636364e-01 -31.03760468 30.3103319 1.0000000
T5:Placebo-T0:Placebo -1.154545e+00 -31.82851377 29.5194229 1.0000000
T6:Placebo-T0:Placebo -2.545455e-01 -30.92851377 30.4194229 1.0000000
T2:Placebo-T1:Placebo 3.445455e+00 -27.22851377 34.1194229 1.0000000
T3:Placebo-T1:Placebo 5.145455e+00 -25.52851377 35.8194229 1.0000000
T4:Placebo-T1:Placebo 7.063636e+00 -23.61033195 37.7376047 1.0000000
T5:Placebo-T1:Placebo 6.272727e+00 -24.40124104 36.9466956 1.0000000
T6:Placebo-T1:Placebo 7.172727e+00 -23.50124104 37.8466956 1.0000000
T3:Placebo-T2:Placebo 1.700000e+00 -28.97396831 32.3739683 1.0000000
T4:Placebo-T2:Placebo 3.618182e+00 -27.05578649 34.2921501 1.0000000
T5:Placebo-T2:Placebo 2.827273e+00 -27.84669558 33.5012410 1.0000000
T6:Placebo-T2:Placebo 3.727273e+00 -26.94669558 34.4012410 1.0000000
T4:Placebo-T3:Placebo 1.918182e+00 -28.75578649 32.5921501 1.0000000
T5:Placebo-T3:Placebo 1.127273e+00 -29.54669558 31.8012410 1.0000000
T6:Placebo-T3:Placebo 2.027273e+00 -28.64669558 32.7012410 1.0000000
T5:Placebo-T4:Placebo -7.909091e-01 -31.46487740 29.8830592 1.0000000
T6:Placebo-T4:Placebo 1.090909e-01 -30.56487740 30.7830592 1.0000000
T6:Placebo-T5:Placebo 9.000000e-01 -29.77396831 31.5739683 1.0000000#mutate
df1 <- df1 %>%
mutate(Colutorio = as.factor(Colutorio))#grafica
df1 %>%
ggline(x = "Tiempo",
y = "Reduccion",
color = "Colutorio",
add = c("mean_se", error.plot = "errorbar")) +
labs(title = "Profile plot de reducción en tiempo y tipo de colutorio") +
theme_pubr()+
ylab("Viability(%)")+
xlab("Timing")
#bonferroni
pairwise.t.test( df1$Reduccion,
df1$Colutorio,
p.adj = "bonferroni")
Pairwise comparisons using t tests with pooled SD
data: df1$Reduccion and df1$Colutorio
CPC(97) CPC+Cy(89) CY(98)
CPC+Cy(89) 0.0058 - -
CY(98) 1.8e-05 6.1e-14 -
Placebo 8.9e-10 < 2e-16 0.1937
P value adjustment method: bonferroni #modelo de aov
aov2 <- aov(Reduccion ~ Tiempo + Colutorio + Tiempo*Colutorio , data = df1)
summary(aov2) Df Sum Sq Mean Sq F value Pr(>F)
Tiempo 6 43467 7245 38.372 < 2e-16 ***
Colutorio 3 38820 12940 68.540 < 2e-16 ***
Tiempo:Colutorio 18 11121 618 3.273 1.03e-05 ***
Residuals 343 64757 189
---
Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1#intra colutorio confocal
aov4 <- lm(Reduccion ~ Tiempo:Colutorio,
data = df1)
summary(aov4)
Call:
lm(formula = Reduccion ~ Tiempo:Colutorio, data = df1)
Residuals:
Min 1Q Median 3Q Max
-43.343 -7.100 0.000 7.161 54.979
Coefficients: (1 not defined because of singularities)
Estimate Std. Error t value Pr(>|t|)
(Intercept) 96.2364 4.1428 23.230 < 2e-16 ***
TiempoT0:ColutorioCPC(97) 3.7636 5.5361 0.680 0.497068
TiempoT1:ColutorioCPC(97) -41.4578 5.5361 -7.489 5.94e-13 ***
TiempoT2:ColutorioCPC(97) -28.8935 5.5361 -5.219 3.12e-07 ***
TiempoT3:ColutorioCPC(97) -28.2221 5.5361 -5.098 5.69e-07 ***
TiempoT4:ColutorioCPC(97) -27.3435 5.5361 -4.939 1.23e-06 ***
TiempoT5:ColutorioCPC(97) -16.8935 5.5361 -3.052 0.002454 **
TiempoT6:ColutorioCPC(97) -3.1149 5.5361 -0.563 0.574035
TiempoT0:ColutorioCPC+Cy(89) 3.7636 5.5361 0.680 0.497068
TiempoT1:ColutorioCPC+Cy(89) -48.8435 5.5361 -8.823 < 2e-16 ***
TiempoT2:ColutorioCPC+Cy(89) -40.0506 5.5361 -7.234 3.08e-12 ***
TiempoT3:ColutorioCPC+Cy(89) -37.5292 5.5361 -6.779 5.30e-11 ***
TiempoT4:ColutorioCPC+Cy(89) -35.7506 5.5361 -6.458 3.64e-10 ***
TiempoT5:ColutorioCPC+Cy(89) -28.9935 5.5361 -5.237 2.85e-07 ***
TiempoT6:ColutorioCPC+Cy(89) -14.7935 5.5361 -2.672 0.007896 **
TiempoT0:ColutorioCY(98) 3.7636 5.5361 0.680 0.497068
TiempoT1:ColutorioCY(98) -19.9864 5.5361 -3.610 0.000352 ***
TiempoT2:ColutorioCY(98) -11.8078 5.5361 -2.133 0.033645 *
TiempoT3:ColutorioCY(98) -14.2864 5.5361 -2.581 0.010279 *
TiempoT4:ColutorioCY(98) -8.0506 5.5361 -1.454 0.146803
TiempoT5:ColutorioCY(98) -4.2006 5.5361 -0.759 0.448509
TiempoT6:ColutorioCY(98) -2.1149 5.5361 -0.382 0.702679
TiempoT0:ColutorioPlacebo 3.7636 5.8589 0.642 0.521053
TiempoT1:ColutorioPlacebo -9.9273 5.8589 -1.694 0.091097 .
TiempoT2:ColutorioPlacebo -0.9636 5.8589 -0.164 0.869454
TiempoT3:ColutorioPlacebo -4.1182 5.8589 -0.703 0.482596
TiempoT4:ColutorioPlacebo -3.2091 5.8589 -0.548 0.584232
TiempoT5:ColutorioPlacebo -0.9182 5.8589 -0.157 0.875560
TiempoT6:ColutorioPlacebo NA NA NA NA
---
Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
Residual standard error: 13.74 on 343 degrees of freedom
Multiple R-squared: 0.5906, Adjusted R-squared: 0.5583
F-statistic: 18.32 on 27 and 343 DF, p-value: < 2.2e-16#tukey
TukeyHSD(aov2) Tukey multiple comparisons of means
95% family-wise confidence level
Fit: aov(formula = Reduccion ~ Tiempo + Colutorio + Tiempo * Colutorio, data = df1)
$Tiempo
diff lwr upr p adj
T1-T0 -34.9566038 -42.8731037 -27.040104 0.0000000
T2-T0 -25.2943396 -33.2108396 -17.377840 0.0000000
T3-T0 -25.7603774 -33.6768773 -17.843877 0.0000000
T4-T0 -23.2226415 -31.1391414 -15.306142 0.0000000
T5-T0 -17.1849057 -25.1014056 -9.268406 0.0000000
T6-T0 -9.0528302 -16.9693301 -1.136330 0.0135555
T2-T1 9.6622642 1.7457642 17.578764 0.0061997
T3-T1 9.1962264 1.2797265 17.112726 0.0113329
T4-T1 11.7339623 3.8174623 19.650462 0.0002943
T5-T1 17.7716981 9.8551982 25.688198 0.0000000
T6-T1 25.9037736 17.9872737 33.820274 0.0000000
T3-T2 -0.4660377 -8.3825377 7.450462 0.9999976
T4-T2 2.0716981 -5.8448018 9.988198 0.9870888
T5-T2 8.1094340 0.1929340 16.025934 0.0406552
T6-T2 16.2415094 8.3250095 24.158009 0.0000001
T4-T3 2.5377358 -5.3787641 10.454236 0.9638045
T5-T3 8.5754717 0.6589718 16.491972 0.0240513
T6-T3 16.7075472 8.7910472 24.624047 0.0000000
T5-T4 6.0377358 -1.8787641 13.954236 0.2657066
T6-T4 14.1698113 6.2533114 22.086311 0.0000041
T6-T5 8.1320755 0.2155755 16.048575 0.0396639
$Colutorio
diff lwr upr p adj
CPC+Cy(89)-CPC(97) -8.576531 -13.6440718 -3.508989 0.0000971
CY(98)-CPC(97) 12.211224 7.1436833 17.278766 0.0000000
Placebo-CPC(97) 18.112709 12.7106917 23.514726 0.0000000
CY(98)-CPC+Cy(89) 20.787755 15.7202139 25.855296 0.0000000
Placebo-CPC+Cy(89) 26.689239 21.2872223 32.091256 0.0000000
Placebo-CY(98) 5.901484 0.4994672 11.303501 0.0260003
$`Tiempo:Colutorio`
diff lwr upr p adj
T1:CPC(97)-T0:CPC(97) -4.522143e+01 -64.67778171 -25.7650754 0.0000000
T2:CPC(97)-T0:CPC(97) -3.265714e+01 -52.11349599 -13.2007897 0.0000004
T3:CPC(97)-T0:CPC(97) -3.198571e+01 -51.44206742 -12.5293612 0.0000008
T4:CPC(97)-T0:CPC(97) -3.110714e+01 -50.56349599 -11.6507897 0.0000020
T5:CPC(97)-T0:CPC(97) -2.065714e+01 -40.11349599 -1.2007897 0.0226672
T6:CPC(97)-T0:CPC(97) -6.878571e+00 -26.33492456 12.5777817 0.9999531
T0:CPC+Cy(89)-T0:CPC(97) 1.278977e-13 -19.45635314 19.4563531 1.0000000
T1:CPC+Cy(89)-T0:CPC(97) -5.260714e+01 -72.06349599 -33.1507897 0.0000000
T2:CPC+Cy(89)-T0:CPC(97) -4.381429e+01 -63.27063885 -24.3579326 0.0000000
T3:CPC+Cy(89)-T0:CPC(97) -4.129286e+01 -60.74921028 -21.8365040 0.0000000
T4:CPC+Cy(89)-T0:CPC(97) -3.951429e+01 -58.97063885 -20.0579326 0.0000000
T5:CPC+Cy(89)-T0:CPC(97) -3.275714e+01 -52.21349599 -13.3007897 0.0000003
T6:CPC+Cy(89)-T0:CPC(97) -1.855714e+01 -38.01349599 0.8992103 0.0859515
T0:CY(98)-T0:CPC(97) -2.131628e-13 -19.45635314 19.4563531 1.0000000
T1:CY(98)-T0:CPC(97) -2.375000e+01 -43.20635314 -4.2936469 0.0021650
T2:CY(98)-T0:CPC(97) -1.557143e+01 -35.02778171 3.8849246 0.3621200
T3:CY(98)-T0:CPC(97) -1.805000e+01 -37.50635314 1.4063531 0.1142873
T4:CY(98)-T0:CPC(97) -1.181429e+01 -31.27063885 7.6420674 0.8815604
T5:CY(98)-T0:CPC(97) -7.964286e+00 -27.42063885 11.4920674 0.9993417
T6:CY(98)-T0:CPC(97) -5.878571e+00 -25.33492456 13.5777817 0.9999980
T0:Placebo-T0:CPC(97) -1.278977e-13 -20.74054213 20.7405421 1.0000000
T1:Placebo-T0:CPC(97) -1.369091e+01 -34.43145122 7.0496330 0.7662908
T2:Placebo-T0:CPC(97) -4.727273e+00 -25.46781486 16.0132694 1.0000000
T3:Placebo-T0:CPC(97) -7.881818e+00 -28.62236031 12.8587239 0.9998205
T4:Placebo-T0:CPC(97) -6.972727e+00 -27.71326940 13.7678149 0.9999824
T5:Placebo-T0:CPC(97) -4.681818e+00 -25.42236031 16.0587239 1.0000000
T6:Placebo-T0:CPC(97) -3.763636e+00 -24.50417849 16.9769058 1.0000000
T2:CPC(97)-T1:CPC(97) 1.256429e+01 -6.89206742 32.0206388 0.8016074
T3:CPC(97)-T1:CPC(97) 1.323571e+01 -6.22063885 32.6920674 0.7123911
T4:CPC(97)-T1:CPC(97) 1.411429e+01 -5.34206742 33.5706388 0.5801453
T5:CPC(97)-T1:CPC(97) 2.456429e+01 5.10793258 44.0206388 0.0010922
T6:CPC(97)-T1:CPC(97) 3.834286e+01 18.88650401 57.7992103 0.0000000
T0:CPC+Cy(89)-T1:CPC(97) 4.522143e+01 25.76507544 64.6777817 0.0000000
T1:CPC+Cy(89)-T1:CPC(97) -7.385714e+00 -26.84206742 12.0706388 0.9998240
T2:CPC+Cy(89)-T1:CPC(97) 1.407143e+00 -18.04921028 20.8634960 1.0000000
T3:CPC+Cy(89)-T1:CPC(97) 3.928571e+00 -15.52778171 23.3849246 1.0000000
T4:CPC+Cy(89)-T1:CPC(97) 5.707143e+00 -13.74921028 25.1634960 0.9999989
T5:CPC+Cy(89)-T1:CPC(97) 1.246429e+01 -6.99206742 31.9206388 0.8135810
T6:CPC+Cy(89)-T1:CPC(97) 2.666429e+01 7.20793258 46.1206388 0.0001672
T0:CY(98)-T1:CPC(97) 4.522143e+01 25.76507544 64.6777817 0.0000000
T1:CY(98)-T1:CPC(97) 2.147143e+01 2.01507544 40.9277817 0.0127284
T2:CY(98)-T1:CPC(97) 2.965000e+01 10.19364686 49.1063531 0.0000090
T3:CY(98)-T1:CPC(97) 2.717143e+01 7.71507544 46.6277817 0.0001039
T4:CY(98)-T1:CPC(97) 3.340714e+01 13.95078972 52.8634960 0.0000002
T5:CY(98)-T1:CPC(97) 3.725714e+01 17.80078972 56.7134960 0.0000000
T6:CY(98)-T1:CPC(97) 3.934286e+01 19.88650401 58.7992103 0.0000000
T0:Placebo-T1:CPC(97) 4.522143e+01 24.48088644 65.9619707 0.0000000
T1:Placebo-T1:CPC(97) 3.153052e+01 10.78997735 52.2710616 0.0000097
T2:Placebo-T1:CPC(97) 4.049416e+01 19.75361371 61.2346980 0.0000000
T3:Placebo-T1:CPC(97) 3.733961e+01 16.59906826 58.0801525 0.0000000
T4:Placebo-T1:CPC(97) 3.824870e+01 17.50815917 58.9892434 0.0000000
T5:Placebo-T1:CPC(97) 4.053961e+01 19.79906826 61.2801525 0.0000000
T6:Placebo-T1:CPC(97) 4.145779e+01 20.71725008 62.1983343 0.0000000
T3:CPC(97)-T2:CPC(97) 6.714286e-01 -18.78492456 20.1277817 1.0000000
T4:CPC(97)-T2:CPC(97) 1.550000e+00 -17.90635314 21.0063531 1.0000000
T5:CPC(97)-T2:CPC(97) 1.200000e+01 -7.45635314 31.4563531 0.8639477
T6:CPC(97)-T2:CPC(97) 2.577857e+01 6.32221829 45.2349246 0.0003761
T0:CPC+Cy(89)-T2:CPC(97) 3.265714e+01 13.20078972 52.1134960 0.0000004
T1:CPC+Cy(89)-T2:CPC(97) -1.995000e+01 -39.40635314 -0.4936469 0.0364448
T2:CPC+Cy(89)-T2:CPC(97) -1.115714e+01 -30.61349599 8.2992103 0.9319804
T3:CPC+Cy(89)-T2:CPC(97) -8.635714e+00 -28.09206742 10.8206388 0.9975573
T4:CPC+Cy(89)-T2:CPC(97) -6.857143e+00 -26.31349599 12.5992103 0.9999558
T5:CPC+Cy(89)-T2:CPC(97) -1.000000e-01 -19.55635314 19.3563531 1.0000000
T6:CPC+Cy(89)-T2:CPC(97) 1.410000e+01 -5.35635314 33.5563531 0.5823618
T0:CY(98)-T2:CPC(97) 3.265714e+01 13.20078972 52.1134960 0.0000004
T1:CY(98)-T2:CPC(97) 8.907143e+00 -10.54921028 28.3634960 0.9960892
T2:CY(98)-T2:CPC(97) 1.708571e+01 -2.37063885 36.5420674 0.1880200
T3:CY(98)-T2:CPC(97) 1.460714e+01 -4.84921028 34.0634960 0.5037391
T4:CY(98)-T2:CPC(97) 2.084286e+01 1.38650401 40.2992103 0.0199272
T5:CY(98)-T2:CPC(97) 2.469286e+01 5.23650401 44.1492103 0.0009781
T6:CY(98)-T2:CPC(97) 2.677857e+01 7.32221829 46.2349246 0.0001503
T0:Placebo-T2:CPC(97) 3.265714e+01 11.91660073 53.3976850 0.0000032
T1:Placebo-T2:CPC(97) 1.896623e+01 -1.77430836 39.7067759 0.1313325
T2:Placebo-T2:CPC(97) 2.792987e+01 7.18932800 48.6704123 0.0002565
T3:Placebo-T2:CPC(97) 2.477532e+01 4.03478254 45.5158668 0.0032763
T4:Placebo-T2:CPC(97) 2.568442e+01 4.94387345 46.4249577 0.0016264
T5:Placebo-T2:CPC(97) 2.797532e+01 7.23478254 48.7158668 0.0002467
T6:Placebo-T2:CPC(97) 2.889351e+01 8.15296436 49.6340486 0.0001107
T4:CPC(97)-T3:CPC(97) 8.785714e-01 -18.57778171 20.3349246 1.0000000
T5:CPC(97)-T3:CPC(97) 1.132857e+01 -8.12778171 30.7849246 0.9205925
T6:CPC(97)-T3:CPC(97) 2.510714e+01 5.65078972 44.5634960 0.0006826
T0:CPC+Cy(89)-T3:CPC(97) 3.198571e+01 12.52936115 51.4420674 0.0000008
T1:CPC+Cy(89)-T3:CPC(97) -2.062143e+01 -40.07778171 -1.1650754 0.0232313
T2:CPC+Cy(89)-T3:CPC(97) -1.182857e+01 -31.28492456 7.6277817 0.8802583
T3:CPC+Cy(89)-T3:CPC(97) -9.307143e+00 -28.76349599 10.1492103 0.9926035
T4:CPC+Cy(89)-T3:CPC(97) -7.528571e+00 -26.98492456 11.9277817 0.9997519
T5:CPC+Cy(89)-T3:CPC(97) -7.714286e-01 -20.22778171 18.6849246 1.0000000
T6:CPC+Cy(89)-T3:CPC(97) 1.342857e+01 -6.02778171 32.8849246 0.6844346
T0:CY(98)-T3:CPC(97) 3.198571e+01 12.52936115 51.4420674 0.0000008
T1:CY(98)-T3:CPC(97) 8.235714e+00 -11.22063885 27.6920674 0.9988515
T2:CY(98)-T3:CPC(97) 1.641429e+01 -3.04206742 35.8706388 0.2564774
T3:CY(98)-T3:CPC(97) 1.393571e+01 -5.52063885 33.3920674 0.6077794
T4:CY(98)-T3:CPC(97) 2.017143e+01 0.71507544 39.6277817 0.0314946
T5:CY(98)-T3:CPC(97) 2.402143e+01 4.56507544 43.4777817 0.0017284
T6:CY(98)-T3:CPC(97) 2.610714e+01 6.65078972 45.5634960 0.0002793
T0:Placebo-T3:CPC(97) 3.198571e+01 11.24517215 52.7262564 0.0000063
T1:Placebo-T3:CPC(97) 1.829481e+01 -2.44573694 39.0353473 0.1811497
T2:Placebo-T3:CPC(97) 2.725844e+01 6.51789943 47.9989837 0.0004531
T3:Placebo-T3:CPC(97) 2.410390e+01 3.36335397 44.8444382 0.0053928
T4:Placebo-T3:CPC(97) 2.501299e+01 4.27244488 45.7535291 0.0027358
T5:Placebo-T3:CPC(97) 2.730390e+01 6.56335397 48.0444382 0.0004362
T6:Placebo-T3:CPC(97) 2.822208e+01 7.48153579 48.9626201 0.0001994
T5:CPC(97)-T4:CPC(97) 1.045000e+01 -9.00635314 29.9063531 0.9669575
T6:CPC(97)-T4:CPC(97) 2.422857e+01 4.77221829 43.6849246 0.0014526
T0:CPC+Cy(89)-T4:CPC(97) 3.110714e+01 11.65078972 50.5634960 0.0000020
T1:CPC+Cy(89)-T4:CPC(97) -2.150000e+01 -40.95635314 -2.0436469 0.0124662
T2:CPC+Cy(89)-T4:CPC(97) -1.270714e+01 -32.16349599 6.7492103 0.7838602
T3:CPC+Cy(89)-T4:CPC(97) -1.018571e+01 -29.64206742 9.2706388 0.9757002
T4:CPC+Cy(89)-T4:CPC(97) -8.407143e+00 -27.86349599 11.0492103 0.9983982
T5:CPC+Cy(89)-T4:CPC(97) -1.650000e+00 -21.10635314 17.8063531 1.0000000
T6:CPC+Cy(89)-T4:CPC(97) 1.255000e+01 -6.90635314 32.0063531 0.8033411
T0:CY(98)-T4:CPC(97) 3.110714e+01 11.65078972 50.5634960 0.0000020
T1:CY(98)-T4:CPC(97) 7.357143e+00 -12.09921028 26.8134960 0.9998359
T2:CY(98)-T4:CPC(97) 1.553571e+01 -3.92063885 34.9920674 0.3670320
T3:CY(98)-T4:CPC(97) 1.305714e+01 -6.39921028 32.5134960 0.7374622
T4:CY(98)-T4:CPC(97) 1.929286e+01 -0.16349599 38.7492103 0.0553612
T5:CY(98)-T4:CPC(97) 2.314286e+01 3.68650401 42.5992103 0.0035455
T6:CY(98)-T4:CPC(97) 2.522857e+01 5.77221829 44.6849246 0.0006136
T0:Placebo-T4:CPC(97) 3.110714e+01 10.36660073 51.8476850 0.0000145
T1:Placebo-T4:CPC(97) 1.741623e+01 -3.32430836 38.1567759 0.2651792
T2:Placebo-T4:CPC(97) 2.637987e+01 5.63932800 47.1204123 0.0009339
T3:Placebo-T4:CPC(97) 2.322532e+01 2.48478254 43.9658668 0.0100914
T4:Placebo-T4:CPC(97) 2.413442e+01 3.39387345 44.8749577 0.0052739
T5:Placebo-T4:CPC(97) 2.642532e+01 5.68478254 47.1658668 0.0009002
T6:Placebo-T4:CPC(97) 2.734351e+01 6.60296436 48.0840486 0.0004219
T6:CPC(97)-T5:CPC(97) 1.377857e+01 -5.67778171 33.2349246 0.6318969
T0:CPC+Cy(89)-T5:CPC(97) 2.065714e+01 1.20078972 40.1134960 0.0226672
T1:CPC+Cy(89)-T5:CPC(97) -3.195000e+01 -51.40635314 -12.4936469 0.0000008
T2:CPC+Cy(89)-T5:CPC(97) -2.315714e+01 -42.61349599 -3.7007897 0.0035052
T3:CPC+Cy(89)-T5:CPC(97) -2.063571e+01 -40.09206742 -1.1793612 0.0230042
T4:CPC+Cy(89)-T5:CPC(97) -1.885714e+01 -38.31349599 0.5992103 0.0721042
T5:CPC+Cy(89)-T5:CPC(97) -1.210000e+01 -31.55635314 7.3563531 0.8538531
T6:CPC+Cy(89)-T5:CPC(97) 2.100000e+00 -17.35635314 21.5563531 1.0000000
T0:CY(98)-T5:CPC(97) 2.065714e+01 1.20078972 40.1134960 0.0226672
T1:CY(98)-T5:CPC(97) -3.092857e+00 -22.54921028 16.3634960 1.0000000
T2:CY(98)-T5:CPC(97) 5.085714e+00 -14.37063885 24.5420674 0.9999999
T3:CY(98)-T5:CPC(97) 2.607143e+00 -16.84921028 22.0634960 1.0000000
T4:CY(98)-T5:CPC(97) 8.842857e+00 -10.61349599 28.2992103 0.9964916
T5:CY(98)-T5:CPC(97) 1.269286e+01 -6.76349599 32.1492103 0.7856679
T6:CY(98)-T5:CPC(97) 1.477857e+01 -4.67778171 34.2349246 0.4774920
T0:Placebo-T5:CPC(97) 2.065714e+01 -0.08339927 41.3976850 0.0525069
T1:Placebo-T5:CPC(97) 6.966234e+00 -13.77430836 27.7067759 0.9999827
T2:Placebo-T5:CPC(97) 1.592987e+01 -4.81067200 36.6704123 0.4525620
T3:Placebo-T5:CPC(97) 1.277532e+01 -7.96521746 33.5158668 0.8654923
T4:Placebo-T5:CPC(97) 1.368442e+01 -7.05612655 34.4249577 0.7670906
T5:Placebo-T5:CPC(97) 1.597532e+01 -4.76521746 36.7158668 0.4461819
T6:Placebo-T5:CPC(97) 1.689351e+01 -3.84703564 37.6340486 0.3252677
T0:CPC+Cy(89)-T6:CPC(97) 6.878571e+00 -12.57778171 26.3349246 0.9999531
T1:CPC+Cy(89)-T6:CPC(97) -4.572857e+01 -65.18492456 -26.2722183 0.0000000
T2:CPC+Cy(89)-T6:CPC(97) -3.693571e+01 -56.39206742 -17.4793612 0.0000000
T3:CPC+Cy(89)-T6:CPC(97) -3.441429e+01 -53.87063885 -14.9579326 0.0000001
T4:CPC+Cy(89)-T6:CPC(97) -3.263571e+01 -52.09206742 -13.1793612 0.0000004
T5:CPC+Cy(89)-T6:CPC(97) -2.587857e+01 -45.33492456 -6.4222183 0.0003437
T6:CPC+Cy(89)-T6:CPC(97) -1.167857e+01 -31.13492456 7.7777817 0.8934895
T0:CY(98)-T6:CPC(97) 6.878571e+00 -12.57778171 26.3349246 0.9999531
T1:CY(98)-T6:CPC(97) -1.687143e+01 -36.32778171 2.5849246 0.2082983
T2:CY(98)-T6:CPC(97) -8.692857e+00 -28.14921028 10.7634960 0.9972956
T3:CY(98)-T6:CPC(97) -1.117143e+01 -30.62778171 8.2849246 0.9310776
T4:CY(98)-T6:CPC(97) -4.935714e+00 -24.39206742 14.5206388 1.0000000
T5:CY(98)-T6:CPC(97) -1.085714e+00 -20.54206742 18.3706388 1.0000000
T6:CY(98)-T6:CPC(97) 1.000000e+00 -18.45635314 20.4563531 1.0000000
T0:Placebo-T6:CPC(97) 6.878571e+00 -13.86197070 27.6191136 0.9999865
T1:Placebo-T6:CPC(97) -6.812338e+00 -27.55287979 13.9282045 0.9999889
T2:Placebo-T6:CPC(97) 2.151299e+00 -18.58924343 22.8918408 1.0000000
T3:Placebo-T6:CPC(97) -1.003247e+00 -21.74378888 19.7372954 1.0000000
T4:Placebo-T6:CPC(97) -9.415584e-02 -20.83469798 20.6463863 1.0000000
T5:Placebo-T6:CPC(97) 2.196753e+00 -18.54378888 22.9372954 1.0000000
T6:Placebo-T6:CPC(97) 3.114935e+00 -17.62560707 23.8554772 1.0000000
T1:CPC+Cy(89)-T0:CPC+Cy(89) -5.260714e+01 -72.06349599 -33.1507897 0.0000000
T2:CPC+Cy(89)-T0:CPC+Cy(89) -4.381429e+01 -63.27063885 -24.3579326 0.0000000
T3:CPC+Cy(89)-T0:CPC+Cy(89) -4.129286e+01 -60.74921028 -21.8365040 0.0000000
T4:CPC+Cy(89)-T0:CPC+Cy(89) -3.951429e+01 -58.97063885 -20.0579326 0.0000000
T5:CPC+Cy(89)-T0:CPC+Cy(89) -3.275714e+01 -52.21349599 -13.3007897 0.0000003
T6:CPC+Cy(89)-T0:CPC+Cy(89) -1.855714e+01 -38.01349599 0.8992103 0.0859515
T0:CY(98)-T0:CPC+Cy(89) -3.410605e-13 -19.45635314 19.4563531 1.0000000
T1:CY(98)-T0:CPC+Cy(89) -2.375000e+01 -43.20635314 -4.2936469 0.0021650
T2:CY(98)-T0:CPC+Cy(89) -1.557143e+01 -35.02778171 3.8849246 0.3621200
T3:CY(98)-T0:CPC+Cy(89) -1.805000e+01 -37.50635314 1.4063531 0.1142873
T4:CY(98)-T0:CPC+Cy(89) -1.181429e+01 -31.27063885 7.6420674 0.8815604
T5:CY(98)-T0:CPC+Cy(89) -7.964286e+00 -27.42063885 11.4920674 0.9993417
T6:CY(98)-T0:CPC+Cy(89) -5.878571e+00 -25.33492456 13.5777817 0.9999980
T0:Placebo-T0:CPC+Cy(89) -2.557954e-13 -20.74054213 20.7405421 1.0000000
T1:Placebo-T0:CPC+Cy(89) -1.369091e+01 -34.43145122 7.0496330 0.7662908
T2:Placebo-T0:CPC+Cy(89) -4.727273e+00 -25.46781486 16.0132694 1.0000000
T3:Placebo-T0:CPC+Cy(89) -7.881818e+00 -28.62236031 12.8587239 0.9998205
T4:Placebo-T0:CPC+Cy(89) -6.972727e+00 -27.71326940 13.7678149 0.9999824
T5:Placebo-T0:CPC+Cy(89) -4.681818e+00 -25.42236031 16.0587239 1.0000000
T6:Placebo-T0:CPC+Cy(89) -3.763636e+00 -24.50417849 16.9769058 1.0000000
T2:CPC+Cy(89)-T1:CPC+Cy(89) 8.792857e+00 -10.66349599 28.2492103 0.9967796
T3:CPC+Cy(89)-T1:CPC+Cy(89) 1.131429e+01 -8.14206742 30.7706388 0.9215881
T4:CPC+Cy(89)-T1:CPC+Cy(89) 1.309286e+01 -6.36349599 32.5492103 0.7325169
T5:CPC+Cy(89)-T1:CPC+Cy(89) 1.985000e+01 0.39364686 39.3063531 0.0388961
T6:CPC+Cy(89)-T1:CPC+Cy(89) 3.405000e+01 14.59364686 53.5063531 0.0000001
T0:CY(98)-T1:CPC+Cy(89) 5.260714e+01 33.15078972 72.0634960 0.0000000
T1:CY(98)-T1:CPC+Cy(89) 2.885714e+01 9.40078972 48.3134960 0.0000201
T2:CY(98)-T1:CPC+Cy(89) 3.703571e+01 17.57936115 56.4920674 0.0000000
T3:CY(98)-T1:CPC+Cy(89) 3.455714e+01 15.10078972 54.0134960 0.0000000
T4:CY(98)-T1:CPC+Cy(89) 4.079286e+01 21.33650401 60.2492103 0.0000000
T5:CY(98)-T1:CPC+Cy(89) 4.464286e+01 25.18650401 64.0992103 0.0000000
T6:CY(98)-T1:CPC+Cy(89) 4.672857e+01 27.27221829 66.1849246 0.0000000
T0:Placebo-T1:CPC+Cy(89) 5.260714e+01 31.86660073 73.3476850 0.0000000
T1:Placebo-T1:CPC+Cy(89) 3.891623e+01 18.17569164 59.6567759 0.0000000
T2:Placebo-T1:CPC+Cy(89) 4.787987e+01 27.13932800 68.6204123 0.0000000
T3:Placebo-T1:CPC+Cy(89) 4.472532e+01 23.98478254 65.4658668 0.0000000
T4:Placebo-T1:CPC+Cy(89) 4.563442e+01 24.89387345 66.3749577 0.0000000
T5:Placebo-T1:CPC+Cy(89) 4.792532e+01 27.18478254 68.6658668 0.0000000
T6:Placebo-T1:CPC+Cy(89) 4.884351e+01 28.10296436 69.5840486 0.0000000
T3:CPC+Cy(89)-T2:CPC+Cy(89) 2.521429e+00 -16.93492456 21.9777817 1.0000000
T4:CPC+Cy(89)-T2:CPC+Cy(89) 4.300000e+00 -15.15635314 23.7563531 1.0000000
T5:CPC+Cy(89)-T2:CPC+Cy(89) 1.105714e+01 -8.39921028 30.5134960 0.9380695
T6:CPC+Cy(89)-T2:CPC+Cy(89) 2.525714e+01 5.80078972 44.7134960 0.0005983
T0:CY(98)-T2:CPC+Cy(89) 4.381429e+01 24.35793258 63.2706388 0.0000000
T1:CY(98)-T2:CPC+Cy(89) 2.006429e+01 0.60793258 39.5206388 0.0338104
T2:CY(98)-T2:CPC+Cy(89) 2.824286e+01 8.78650401 47.6992103 0.0000370
T3:CY(98)-T2:CPC+Cy(89) 2.576429e+01 6.30793258 45.2206388 0.0003809
T4:CY(98)-T2:CPC+Cy(89) 3.200000e+01 12.54364686 51.4563531 0.0000008
T5:CY(98)-T2:CPC+Cy(89) 3.585000e+01 16.39364686 55.3063531 0.0000000
T6:CY(98)-T2:CPC+Cy(89) 3.793571e+01 18.47936115 57.3920674 0.0000000
T0:Placebo-T2:CPC+Cy(89) 4.381429e+01 23.07374358 64.5548278 0.0000000
T1:Placebo-T2:CPC+Cy(89) 3.012338e+01 9.38283449 50.8639188 0.0000364
T2:Placebo-T2:CPC+Cy(89) 3.908701e+01 18.34647086 59.8275551 0.0000000
T3:Placebo-T2:CPC+Cy(89) 3.593247e+01 15.19192540 56.6730097 0.0000001
T4:Placebo-T2:CPC+Cy(89) 3.684156e+01 16.10101631 57.5821006 0.0000000
T5:Placebo-T2:CPC+Cy(89) 3.913247e+01 18.39192540 59.8730097 0.0000000
T6:Placebo-T2:CPC+Cy(89) 4.005065e+01 19.31010722 60.7911915 0.0000000
T4:CPC+Cy(89)-T3:CPC+Cy(89) 1.778571e+00 -17.67778171 21.2349246 1.0000000
T5:CPC+Cy(89)-T3:CPC+Cy(89) 8.535714e+00 -10.92063885 27.9920674 0.9979630
T6:CPC+Cy(89)-T3:CPC+Cy(89) 2.273571e+01 3.27936115 42.1920674 0.0048943
T0:CY(98)-T3:CPC+Cy(89) 4.129286e+01 21.83650401 60.7492103 0.0000000
T1:CY(98)-T3:CPC+Cy(89) 1.754286e+01 -1.91349599 36.9992103 0.1495948
T2:CY(98)-T3:CPC+Cy(89) 2.572143e+01 6.26507544 45.1777817 0.0003959
T3:CY(98)-T3:CPC+Cy(89) 2.324286e+01 3.78650401 42.6992103 0.0032722
T4:CY(98)-T3:CPC+Cy(89) 2.947857e+01 10.02221829 48.9349246 0.0000107
T5:CY(98)-T3:CPC+Cy(89) 3.332857e+01 13.87221829 52.7849246 0.0000002
T6:CY(98)-T3:CPC+Cy(89) 3.541429e+01 15.95793258 54.8706388 0.0000000
T0:Placebo-T3:CPC+Cy(89) 4.129286e+01 20.55231501 62.0333993 0.0000000
T1:Placebo-T3:CPC+Cy(89) 2.760195e+01 6.86140592 48.3424902 0.0003392
T2:Placebo-T3:CPC+Cy(89) 3.656558e+01 15.82504228 57.3061265 0.0000001
T3:Placebo-T3:CPC+Cy(89) 3.341104e+01 12.67049683 54.1515811 0.0000015
T4:Placebo-T3:CPC+Cy(89) 3.432013e+01 13.57958774 55.0606720 0.0000006
T5:Placebo-T3:CPC+Cy(89) 3.661104e+01 15.87049683 57.3515811 0.0000001
T6:Placebo-T3:CPC+Cy(89) 3.752922e+01 16.78867865 58.2697629 0.0000000
T5:CPC+Cy(89)-T4:CPC+Cy(89) 6.757143e+00 -12.69921028 26.2134960 0.9999667
T6:CPC+Cy(89)-T4:CPC+Cy(89) 2.095714e+01 1.50078972 40.4134960 0.0183931
T0:CY(98)-T4:CPC+Cy(89) 3.951429e+01 20.05793258 58.9706388 0.0000000
T1:CY(98)-T4:CPC+Cy(89) 1.576429e+01 -3.69206742 35.2206388 0.3361616
T2:CY(98)-T4:CPC+Cy(89) 2.394286e+01 4.48650401 43.3992103 0.0018454
T3:CY(98)-T4:CPC+Cy(89) 2.146429e+01 2.00793258 40.9206388 0.0127947
T4:CY(98)-T4:CPC+Cy(89) 2.770000e+01 8.24364686 47.1563531 0.0000627
T5:CY(98)-T4:CPC+Cy(89) 3.155000e+01 12.09364686 51.0063531 0.0000012
T6:CY(98)-T4:CPC+Cy(89) 3.363571e+01 14.17936115 53.0920674 0.0000001
T0:Placebo-T4:CPC+Cy(89) 3.951429e+01 18.77374358 60.2548278 0.0000000
T1:Placebo-T4:CPC+Cy(89) 2.582338e+01 5.08283449 46.5639188 0.0014576
T2:Placebo-T4:CPC+Cy(89) 3.478701e+01 14.04647086 55.5275551 0.0000004
T3:Placebo-T4:CPC+Cy(89) 3.163247e+01 10.89192540 52.3730097 0.0000088
T4:Placebo-T4:CPC+Cy(89) 3.254156e+01 11.80101631 53.2821006 0.0000036
T5:Placebo-T4:CPC+Cy(89) 3.483247e+01 14.09192540 55.5730097 0.0000004
T6:Placebo-T4:CPC+Cy(89) 3.575065e+01 15.01010722 56.4911915 0.0000001
T6:CPC+Cy(89)-T5:CPC+Cy(89) 1.420000e+01 -5.25635314 33.6563531 0.5668344
T0:CY(98)-T5:CPC+Cy(89) 3.275714e+01 13.30078972 52.2134960 0.0000003
T1:CY(98)-T5:CPC+Cy(89) 9.007143e+00 -10.44921028 28.4634960 0.9953856
T2:CY(98)-T5:CPC+Cy(89) 1.718571e+01 -2.27063885 36.6420674 0.1790572
T3:CY(98)-T5:CPC+Cy(89) 1.470714e+01 -4.74921028 34.1634960 0.4883919
T4:CY(98)-T5:CPC+Cy(89) 2.094286e+01 1.48650401 40.3992103 0.0185789
T5:CY(98)-T5:CPC+Cy(89) 2.479286e+01 5.33650401 44.2492103 0.0008973
T6:CY(98)-T5:CPC+Cy(89) 2.687857e+01 7.42221829 46.3349246 0.0001369
T0:Placebo-T5:CPC+Cy(89) 3.275714e+01 12.01660073 53.4976850 0.0000029
T1:Placebo-T5:CPC+Cy(89) 1.906623e+01 -1.67430836 39.8067759 0.1249210
T2:Placebo-T5:CPC+Cy(89) 2.802987e+01 7.28932800 48.7704123 0.0002354
T3:Placebo-T5:CPC+Cy(89) 2.487532e+01 4.13478254 45.6158668 0.0030377
T4:Placebo-T5:CPC+Cy(89) 2.578442e+01 5.04387345 46.5249577 0.0015032
T5:Placebo-T5:CPC+Cy(89) 2.807532e+01 7.33478254 48.8158668 0.0002263
T6:Placebo-T5:CPC+Cy(89) 2.899351e+01 8.25296436 49.7340486 0.0001013
T0:CY(98)-T6:CPC+Cy(89) 1.855714e+01 -0.89921028 38.0134960 0.0859515
T1:CY(98)-T6:CPC+Cy(89) -5.192857e+00 -24.64921028 14.2634960 0.9999999
T2:CY(98)-T6:CPC+Cy(89) 2.985714e+00 -16.47063885 22.4420674 1.0000000
T3:CY(98)-T6:CPC+Cy(89) 5.071429e-01 -18.94921028 19.9634960 1.0000000
T4:CY(98)-T6:CPC+Cy(89) 6.742857e+00 -12.71349599 26.1992103 0.9999680
T5:CY(98)-T6:CPC+Cy(89) 1.059286e+01 -8.86349599 30.0492103 0.9613295
T6:CY(98)-T6:CPC+Cy(89) 1.267857e+01 -6.77778171 32.1349246 0.7874684
T0:Placebo-T6:CPC+Cy(89) 1.855714e+01 -2.18339927 39.2976850 0.1602462
T1:Placebo-T6:CPC+Cy(89) 4.866234e+00 -15.87430836 25.6067759 1.0000000
T2:Placebo-T6:CPC+Cy(89) 1.382987e+01 -6.91067200 34.5704123 0.7488907
T3:Placebo-T6:CPC+Cy(89) 1.067532e+01 -10.06521746 31.4158668 0.9803249
T4:Placebo-T6:CPC+Cy(89) 1.158442e+01 -9.15612655 32.3249577 0.9485553
T5:Placebo-T6:CPC+Cy(89) 1.387532e+01 -6.86521746 34.6158668 0.7430855
T6:Placebo-T6:CPC+Cy(89) 1.479351e+01 -5.94703564 35.5340486 0.6167354
T1:CY(98)-T0:CY(98) -2.375000e+01 -43.20635314 -4.2936469 0.0021650
T2:CY(98)-T0:CY(98) -1.557143e+01 -35.02778171 3.8849246 0.3621200
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T4:CY(98)-T0:CY(98) -1.181429e+01 -31.27063885 7.6420674 0.8815604
T5:CY(98)-T0:CY(98) -7.964286e+00 -27.42063885 11.4920674 0.9993417
T6:CY(98)-T0:CY(98) -5.878571e+00 -25.33492456 13.5777817 0.9999980
T0:Placebo-T0:CY(98) 8.526513e-14 -20.74054213 20.7405421 1.0000000
T1:Placebo-T0:CY(98) -1.369091e+01 -34.43145122 7.0496330 0.7662908
T2:Placebo-T0:CY(98) -4.727273e+00 -25.46781486 16.0132694 1.0000000
T3:Placebo-T0:CY(98) -7.881818e+00 -28.62236031 12.8587239 0.9998205
T4:Placebo-T0:CY(98) -6.972727e+00 -27.71326940 13.7678149 0.9999824
T5:Placebo-T0:CY(98) -4.681818e+00 -25.42236031 16.0587239 1.0000000
T6:Placebo-T0:CY(98) -3.763636e+00 -24.50417849 16.9769058 1.0000000
T2:CY(98)-T1:CY(98) 8.178571e+00 -11.27778171 27.6349246 0.9989753
T3:CY(98)-T1:CY(98) 5.700000e+00 -13.75635314 25.1563531 0.9999990
T4:CY(98)-T1:CY(98) 1.193571e+01 -7.52063885 31.3920674 0.8702121
T5:CY(98)-T1:CY(98) 1.578571e+01 -3.67063885 35.2420674 0.3333385
T6:CY(98)-T1:CY(98) 1.787143e+01 -1.58492456 37.3277817 0.1258811
T0:Placebo-T1:CY(98) 2.375000e+01 3.00945787 44.4905421 0.0069659
T1:Placebo-T1:CY(98) 1.005909e+01 -10.68145122 30.7996330 0.9910359
T2:Placebo-T1:CY(98) 1.902273e+01 -1.71781486 39.7632694 0.1276796
T3:Placebo-T1:CY(98) 1.586818e+01 -4.87236031 36.6087239 0.4612644
T4:Placebo-T1:CY(98) 1.677727e+01 -3.96326940 37.5178149 0.3395783
T5:Placebo-T1:CY(98) 1.906818e+01 -1.67236031 39.8087239 0.1247986
T6:Placebo-T1:CY(98) 1.998636e+01 -0.75417849 40.7269058 0.0768696
T3:CY(98)-T2:CY(98) -2.478571e+00 -21.93492456 16.9777817 1.0000000
T4:CY(98)-T2:CY(98) 3.757143e+00 -15.69921028 23.2134960 1.0000000
T5:CY(98)-T2:CY(98) 7.607143e+00 -11.84921028 27.0634960 0.9997018
T6:CY(98)-T2:CY(98) 9.692857e+00 -9.76349599 29.1492103 0.9871060
T0:Placebo-T2:CY(98) 1.557143e+01 -5.16911356 36.3119707 0.5037157
T1:Placebo-T2:CY(98) 1.880519e+00 -18.86002265 22.6210616 1.0000000
T2:Placebo-T2:CY(98) 1.084416e+01 -9.89638629 31.5846980 0.9760781
T3:Placebo-T2:CY(98) 7.689610e+00 -13.05093174 28.4301525 0.9998856
T4:Placebo-T2:CY(98) 8.598701e+00 -12.14184083 29.3392434 0.9991850
T5:Placebo-T2:CY(98) 1.088961e+01 -9.85093174 31.6301525 0.9748205
T6:Placebo-T2:CY(98) 1.180779e+01 -8.93274992 32.5483343 0.9369107
T4:CY(98)-T3:CY(98) 6.235714e+00 -13.22063885 25.6920674 0.9999932
T5:CY(98)-T3:CY(98) 1.008571e+01 -9.37063885 29.5420674 0.9784917
T6:CY(98)-T3:CY(98) 1.217143e+01 -7.28492456 31.6277817 0.8463846
T0:Placebo-T3:CY(98) 1.805000e+01 -2.69054213 38.7905421 0.2023788
T1:Placebo-T3:CY(98) 4.359091e+00 -16.38145122 25.0996330 1.0000000
T2:Placebo-T3:CY(98) 1.332273e+01 -7.41781486 34.0632694 0.8096074
T3:Placebo-T3:CY(98) 1.016818e+01 -10.57236031 30.9087239 0.9896073
T4:Placebo-T3:CY(98) 1.107727e+01 -9.66326940 31.8178149 0.9690766
T5:Placebo-T3:CY(98) 1.336818e+01 -7.37236031 34.1087239 0.8044938
T6:Placebo-T3:CY(98) 1.428636e+01 -6.45417849 35.0269058 0.6883646
T5:CY(98)-T4:CY(98) 3.850000e+00 -15.60635314 23.3063531 1.0000000
T6:CY(98)-T4:CY(98) 5.935714e+00 -13.52063885 25.3920674 0.9999976
T0:Placebo-T4:CY(98) 1.181429e+01 -8.92625642 32.5548278 0.9365465
T1:Placebo-T4:CY(98) -1.876623e+00 -22.61716551 18.8639188 1.0000000
T2:Placebo-T4:CY(98) 7.087013e+00 -13.65352914 27.8275551 0.9999757
T3:Placebo-T4:CY(98) 3.932468e+00 -16.80807460 24.6730097 1.0000000
T4:Placebo-T4:CY(98) 4.841558e+00 -15.89898369 25.5821006 1.0000000
T5:Placebo-T4:CY(98) 7.132468e+00 -13.60807460 27.8730097 0.9999725
T6:Placebo-T4:CY(98) 8.050649e+00 -12.68989278 28.7911915 0.9997377
T6:CY(98)-T5:CY(98) 2.085714e+00 -17.37063885 21.5420674 1.0000000
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T3:Placebo-T5:CY(98) 8.246753e-02 -20.65807460 20.8230097 1.0000000
T4:Placebo-T5:CY(98) 9.915584e-01 -19.74898369 21.7321006 1.0000000
T5:Placebo-T5:CY(98) 3.282468e+00 -17.45807460 24.0230097 1.0000000
T6:Placebo-T5:CY(98) 4.200649e+00 -16.53989278 24.9411915 1.0000000
T0:Placebo-T6:CY(98) 5.878571e+00 -14.86197070 26.6191136 0.9999995
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T5:Placebo-T6:CY(98) 1.196753e+00 -19.54378888 21.9372954 1.0000000
T6:Placebo-T6:CY(98) 2.114935e+00 -18.62560707 22.8554772 1.0000000
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