The interactive plots below allow you to explore the detailed results behind each aggregated data point. A tooltip will show the following information when the mouse pointer is over a data point:

  • Drug, Treatment,
  • Region (only when the data was grouped by Region),
  • fraction of time with pH>4 per 24 hours (%) with pooled number of subjects (PP),
  • EE-healing rate (%) with pooled std.err. (on the logit scale) and pooled number of subjects (ITT)

1 Pooled by Region

EE Healing Rates
Region pH>4 HTR (%) Studies Week 4 Week 8
Placebo
Asian 12.0 (N=87) Kar (415), Ohara (427) 13.3 (SE=1.49, N=15) 13.6 (SE=0.44, N=169)
Non-Asian 8.6 (N=95) Richter (318), Earnest (320), Roufail (333), Silver (342), Euler (348), Castell (349), Hetzel (358), Sontag (359), Cloud (385), Howard (393), Johansson (418) 18.3 (SE=0.42, N=936) 24.9 (SE=0.47, N=962)
Azeloprazole
10mg od Asian 57.5 (N=18) Kinoshita 2018 89.6 (SE=0.57, N=125) 94.4 (SE=0.76, N=125)
20mg od Asian 64.5 (N=71) Kinoshita 2018 89.7 (SE=0.57, N=126) 96.8 (SE=1.00, N=126)
40mg od Asian 72.4 (N=18) Kinoshita 2018 92.1 (SE=0.65, N=126) 94.4 (SE=0.76, N=126)
Dexlansoprazole
60mg od Non-Asian 68.1 (N=272) Sharma (420) No Data 86.1 (SE=0.99, N=1374)
90mg od Non-Asian 69.8 (N=40) Sharma (420) No Data 87.6 (SE=1.49, N=1355)
Esomeprazole
20mg od Non-Asian 54.1 (N=265) Kahrilas (305), Lightdale (397) No Data 85.7 (SE=1.03, N=1244)
20mg bid Asian 73.2 (N=20) Sun 2019 No Data 83.6 (SE=0.65, N=67)
40mg od Asian 70.4 (N=140) Chen (390), Zheng (421), Maiti (423), Xue 2018, Lee 2019, Lee 2017, Xue 2017 71.6 (SE=1.64, N=450) 81.2 (SE=0.95, N=566)
40mg od Non-Asian 63.7 (N=371) Kahrilas (305), Richter (306), Castell (307), Howden (380), Gillessen (388), Fennerty (386), Labenz (384), Schneider (337), Vcev (395), Schmitt (396), Kahrilas (402), Bardhan (406), Laine (422), Moraes-Filho (432) 71.7 (SE=0.26, N=9613) 86.1 (SE=0.23, N=9335)
Famotidine
20mg bid Asian 37.0 (N=10) Soga (309), Kawano (327), Ohara (427), Kim 2015 33.3 (SE=0.80, N=27) 56.6 (SE=0.33, N=387)
Ilaprazole
10mg od Asian 77.2 (N=54) Xue 2018, Xue 2017 77.4 (SE=1.47, N=429) 84.8 (SE=1.71, N=429)
Lansoprazole
15mg od Non-Asian 41.4 (N=279) Earnest (320), Castell (349) 70.0 (SE=1.63, N=290) 77.2 (SE=1.78, N=290)
30mg od Asian 52.0 (N=28) Adachi (328), Zheng (421), Xiao 2020, Ashida 2015, Ashida 2016 87.1 (SE=0.98, N=578) 88.6 (SE=0.72, N=672)
30mg od Non-Asian 55.8 (N=532) Mee (302), Castell (307), Hatlebakk (311), Earnest (320), Jansen (325), Robinson (339), Bardhan (340), Castell (349), Vcev (377), Dupas (379), Howden (380), Mulder (382), Fennerty (386), Pilotto (404), Sharma (420) 74.1 (SE=0.31, N=4785) 85.8 (SE=0.23, N=6228)
60mg od Non-Asian 55.2 (N=51) Earnest (320), Bardhan (340) 70.8 (SE=2.31, N=154) 83.9 (SE=3.34, N=154)
Nizatidine
150mg bid Non-Asian 18.1 (N=42) Kovacs (324), Armstrong (391) 30.9 (SE=4.09, N=130) 37.5 (SE=0.48, N=72)
Omeprazole
10mg od Non-Asian 32.8 (N=23) Carlsson (381) 55.8 (SE=0.34, N=138) No Data
20mg od Asian 58.5 (N=50) Soga (309), Kawano (327), Adachi (328), Chen (390), Zheng (421), Kim 2015 72.4 (SE=0.81, N=29) 78.4 (SE=0.91, N=353)
20mg od Non-Asian 49.7 (N=225) Mee (302), Dekkers (303), Delchier (304), Kahrilas (305), Richter (306), Hatlebakk (311), Italy group (315), Bate (316), Bate (329), Ronbinson (335), BATE (336), Moisner (341), Bardhan (345), Castell (349), Hetzel (358), Sontag (359), Corinaldesi (366), Sandmark (373), Ruth (374), Laursen (376), Vce V (377), Vce V (378), Carlsson (381), Howard (393), Pace (394), Schmitt (396), Lightdale (397), 369+400, Pilotto (404), Green (414) 66.0 (SE=0.27, N=5527) 81.5 (SE=0.23, N=5937)
40mg od Non-Asian 60.8 (N=59) Korner (326), Havelund (351), Vantrappen (354), Hetzel (358), Sontag (359), Dehn (360), Laursen (376), Mulder (382), Holtmann (398), Marakhouski 2017 66.7 (SE=0.52, N=987) 80.2 (SE=0.38, N=1010)
Pantoprazole
10mg od Non-Asian 34.9 (N=36) Richter (318) 42.0 (SE=0.30, N=174) 58.6 (SE=0.30, N=174)
20mg od Non-Asian 40.8 (N=76) Van Zyl (310), Richter (318), Moretzsohn (319), Dettmer (323), Kovacs (324), Bardhan (345) 66.9 (SE=0.41, N=647) 78.8 (SE=0.27, N=619)
40mg od Non-Asian 48.6 (N=200) Richter (318), Moretzsohn (319), Armbrecht (321), Kovacs (324), Korner (326), Mossner (341), Van Rensburg (343), Corinaldesi (366), Koop (367), VceV (378), Dupas (379), Armstrong (391), Gillessen (388), Meneghelli (392), Labenz (384), Van Rensburg (387), Vcev (395), Pilotto (404), Bardhan (406), Hein (429), Moraes-Filho (432) 68.8 (SE=0.16, N=4880) 84.5 (SE=0.17, N=4853)
80mg od Non-Asian 28.0 (N=15) Van Rensburg (343) 66.3 (SE=0.43, N=95) 86.3 (SE=0.59, N=95)
Rabeprazole
10mg od Asian 60.7 (N=123) Kinoshita 2018 89.7 (SE=0.57, N=126) 96.8 (SE=1.00, N=126)
10mg od Non-Asian 51.5 (N=123) Cloud (385) No Data 92.6 (SE=1.44, N=27)
20mg od Asian 68.7 (N=34) Adachi (328), Pai (405) 34.8 (SE=0.86, N=23) 86.7 (SE=1.05, N=30)
20mg od Non-Asian 58.9 (N=135) Dekkers (303), Delchier (304), Farley (312), Cloud (385), Pace (394), Holtmann (398), Pilotto (404) 75.4 (SE=0.70, N=781) 86.1 (SE=0.43, N=886)
40mg od Asian 71.5 (N=16) Maiti (423) 50.0 (SE=0.72, N=30) No Data
Rabeprazole (ER)
50mg od Non-Asian 81.5 (N=59) Laine (422) 52.7 (SE=0.12, N=1056) 78.4 (SE=0.15, N=1056)
Ranitidine
300mg od Non-Asian 36.7 (N=44) Johnson (313), Halvorse (330), Green (414) 18.7 (SE=1.71, N=438) 46.5 (SE=0.48, N=567)
150mg qid Non-Asian 38.0 (N=27) Farley (312), McCarty-Dawson (317), Roufail (333), Silver (342), Euler (348) 41.4 (SE=0.30, N=874) 63.6 (SE=0.28, N=874)
Tegoprazan
50mg od Asian 68.2 (N=8) Lee 2019 87.0 (SE=0.58, N=100) 95.0 (SE=0.90, N=100)
100mg od Asian 70.4 (N=6) Lee 2019 90.2 (SE=0.65, N=102) 95.1 (SE=0.90, N=102)
Vonoprazan
10mg od Asian 66.8 (N=19) Ashida 2015, Okanobu 2021 86.7 (SE=2.78, N=181) 87.6 (SE=0.49, N=145)
20mg od Asian 89.1 (N=46) Xiao 2020, Ashida 2015, Okanobu 2021, Ashida 2016 91.0 (SE=1.05, N=642) 93.9 (SE=1.86, N=605)
40mg od Asian 100.0 (N=9) Ashida 2015 89.0 (SE=0.52, N=146) 89.0 (SE=0.52, N=146)

2 Pooled Across Regions

EE Healing Rates
pH>4 HTR (%) Studies Week 4 Week 8
Placebo
10.2 (N=182) Richter (318), Earnest (320), Roufail (333), Silver (342), Euler (348), Castell (349), Hetzel (358), Sontag (359), Cloud (385), Howard (393), Kar (415), Johansson (418), Ohara (427) 18.1 (SE=0.40, N=951) 23.1 (SE=0.45, N=1131)
Azeloprazole
10mg od 57.5 (N=18) Kinoshita 2018 89.6 (SE=0.57, N=125) 94.4 (SE=0.76, N=125)
20mg od 64.5 (N=71) Kinoshita 2018 89.7 (SE=0.57, N=126) 96.8 (SE=1.00, N=126)
40mg od 72.4 (N=18) Kinoshita 2018 92.1 (SE=0.65, N=126) 94.4 (SE=0.76, N=126)
Dexlansoprazole
60mg od 68.1 (N=272) Sharma (420) No Data 86.1 (SE=0.99, N=1374)
90mg od 69.8 (N=40) Sharma (420) No Data 87.6 (SE=1.49, N=1355)
Esomeprazole
20mg od 55.6 (N=303) Kahrilas (305), Lightdale (397) No Data 85.7 (SE=1.03, N=1244)
20mg od 58.7 (N=124) Kahrilas (305), Lightdale (397) No Data 85.7 (SE=1.03, N=1244)
20mg bid 73.2 (N=20) Sun 2019 No Data 83.6 (SE=0.65, N=67)
20mg bid 73.9 (N=97) Sun 2019 No Data 83.6 (SE=0.65, N=67)
20mg bid 74.9 (N=13) Sun 2019 No Data 83.6 (SE=0.65, N=67)
40mg od 60.5 (N=114) Kahrilas (305), Richter (306), Castell (307), Howden (380), Gillessen (388), Fennerty (386), Chen (390), Labenz (384), Schneider (337), Vcev (395), Schmitt (396), Kahrilas (402), Bardhan (406), Zheng (421), Laine (422), Maiti (423), Moraes-Filho (432), Xue 2018, Lee 2019, Lee 2017, Xue 2017 72.0 (SE=0.29, N=10063) 84.9 (SE=0.27, N=9901)
40mg od 67.0 (N=384) Kahrilas (305), Richter (306), Castell (307), Howden (380), Gillessen (388), Fennerty (386), Chen (390), Labenz (384), Schneider (337), Vcev (395), Schmitt (396), Kahrilas (402), Bardhan (406), Zheng (421), Laine (422), Maiti (423), Moraes-Filho (432), Xue 2018, Lee 2019, Lee 2017, Xue 2017 72.0 (SE=0.29, N=10063) 84.9 (SE=0.27, N=9901)
40mg od 67.7 (N=13) Kahrilas (305), Richter (306), Castell (307), Howden (380), Gillessen (388), Fennerty (386), Chen (390), Labenz (384), Schneider (337), Vcev (395), Schmitt (396), Kahrilas (402), Bardhan (406), Zheng (421), Laine (422), Maiti (423), Moraes-Filho (432), Xue 2018, Lee 2019, Lee 2017, Xue 2017 72.0 (SE=0.29, N=10063) 84.9 (SE=0.27, N=9901)
Famotidine
20mg bid 33.6 (N=30) Soga (309), Kawano (327), Ohara (427), Kim 2015 33.3 (SE=0.80, N=27) 56.6 (SE=0.33, N=387)
20mg bid 37.0 (N=10) Soga (309), Kawano (327), Ohara (427), Kim 2015 33.3 (SE=0.80, N=27) 56.6 (SE=0.33, N=387)
Ilaprazole
10mg od 68.0 (N=8) Xue 2018, Xue 2017 77.4 (SE=1.47, N=429) 84.8 (SE=1.71, N=429)
10mg od 78.8 (N=46) Xue 2018, Xue 2017 77.4 (SE=1.47, N=429) 84.8 (SE=1.71, N=429)
Lansoprazole
15mg od 42.7 (N=209) Earnest (320), Castell (349) 70.0 (SE=1.63, N=290) 77.2 (SE=1.78, N=290)
15mg od 44.2 (N=11) Earnest (320), Castell (349) 70.0 (SE=1.63, N=290) 77.2 (SE=1.78, N=290)
15mg od 44.3 (N=101) Earnest (320), Castell (349) 70.0 (SE=1.63, N=290) 77.2 (SE=1.78, N=290)
30mg od 44.2 (N=125) Mee (302), Castell (307), Hatlebakk (311), Earnest (320), Jansen (325), Adachi (328), Robinson (339), Bardhan (340), Castell (349), Vcev (377), Dupas (379), Howden (380), Mulder (382), Fennerty (386), Pilotto (404), Sharma (420), Zheng (421), Xiao 2020, Ashida 2015, Ashida 2016 77.3 (SE=0.32, N=5363) 86.6 (SE=0.21, N=6900)
30mg od 57.6 (N=397) Mee (302), Castell (307), Hatlebakk (311), Earnest (320), Jansen (325), Adachi (328), Robinson (339), Bardhan (340), Castell (349), Vcev (377), Dupas (379), Howden (380), Mulder (382), Fennerty (386), Pilotto (404), Sharma (420), Zheng (421), Xiao 2020, Ashida 2015, Ashida 2016 77.3 (SE=0.32, N=5363) 86.6 (SE=0.21, N=6900)
30mg od 73.1 (N=38) Mee (302), Castell (307), Hatlebakk (311), Earnest (320), Jansen (325), Adachi (328), Robinson (339), Bardhan (340), Castell (349), Vcev (377), Dupas (379), Howden (380), Mulder (382), Fennerty (386), Pilotto (404), Sharma (420), Zheng (421), Xiao 2020, Ashida 2015, Ashida 2016 77.3 (SE=0.32, N=5363) 86.6 (SE=0.21, N=6900)
60mg od 55.2 (N=51) Earnest (320), Bardhan (340) 70.8 (SE=2.31, N=154) 83.9 (SE=3.34, N=154)
Nizatidine
150mg bid 18.1 (N=42) Kovacs (324), Armstrong (391) 30.9 (SE=4.09, N=130) 37.5 (SE=0.48, N=72)
Omeprazole
10mg od 26.0 (N=12) Carlsson (381) 55.8 (SE=0.34, N=138) No Data
10mg od 40.3 (N=11) Carlsson (381) 55.8 (SE=0.34, N=138) No Data
20mg od 50.4 (N=149) Mee (302), Dekkers (303), Delchier (304), Kahrilas (305), Richter (306), Soga (309), Hatlebakk (311), Italy group (315), Bate (316), Kawano (327), Adachi (328), Bate (329), Ronbinson (335), BATE (336), Moisner (341), Bardhan (345), Castell (349), Hetzel (358), Sontag (359), Corinaldesi (366), Sandmark (373), Ruth (374), Laursen (376), Vce V (377), Vce V (378), Carlsson (381), Howard (393), Chen (390), Pace (394), Schmitt (396), Lightdale (397), 369+400, Pilotto (404), Green (414), Zheng (421), Kim 2015 66.2 (SE=0.26, N=5556) 81.1 (SE=0.22, N=6290)
20mg od 51.2 (N=28) Mee (302), Dekkers (303), Delchier (304), Kahrilas (305), Richter (306), Soga (309), Hatlebakk (311), Italy group (315), Bate (316), Kawano (327), Adachi (328), Bate (329), Ronbinson (335), BATE (336), Moisner (341), Bardhan (345), Castell (349), Hetzel (358), Sontag (359), Corinaldesi (366), Sandmark (373), Ruth (374), Laursen (376), Vce V (377), Vce V (378), Carlsson (381), Howard (393), Chen (390), Pace (394), Schmitt (396), Lightdale (397), 369+400, Pilotto (404), Green (414), Zheng (421), Kim 2015 66.2 (SE=0.26, N=5556) 81.1 (SE=0.22, N=6290)
20mg od 51.3 (N=16) Mee (302), Dekkers (303), Delchier (304), Kahrilas (305), Richter (306), Soga (309), Hatlebakk (311), Italy group (315), Bate (316), Kawano (327), Adachi (328), Bate (329), Ronbinson (335), BATE (336), Moisner (341), Bardhan (345), Castell (349), Hetzel (358), Sontag (359), Corinaldesi (366), Sandmark (373), Ruth (374), Laursen (376), Vce V (377), Vce V (378), Carlsson (381), Howard (393), Chen (390), Pace (394), Schmitt (396), Lightdale (397), 369+400, Pilotto (404), Green (414), Zheng (421), Kim 2015 66.2 (SE=0.26, N=5556) 81.1 (SE=0.22, N=6290)
20mg od 52.9 (N=82) Mee (302), Dekkers (303), Delchier (304), Kahrilas (305), Richter (306), Soga (309), Hatlebakk (311), Italy group (315), Bate (316), Kawano (327), Adachi (328), Bate (329), Ronbinson (335), BATE (336), Moisner (341), Bardhan (345), Castell (349), Hetzel (358), Sontag (359), Corinaldesi (366), Sandmark (373), Ruth (374), Laursen (376), Vce V (377), Vce V (378), Carlsson (381), Howard (393), Chen (390), Pace (394), Schmitt (396), Lightdale (397), 369+400, Pilotto (404), Green (414), Zheng (421), Kim 2015 66.2 (SE=0.26, N=5556) 81.1 (SE=0.22, N=6290)
40mg od 61.4 (N=85) Korner (326), Havelund (351), Vantrappen (354), Hetzel (358), Sontag (359), Dehn (360), Laursen (376), Mulder (382), Holtmann (398), Marakhouski 2017 66.7 (SE=0.52, N=987) 80.2 (SE=0.38, N=1010)
Pantoprazole
10mg od 34.9 (N=36) Richter (318) 42.0 (SE=0.30, N=174) 58.6 (SE=0.30, N=174)
20mg od 39.5 (N=41) Van Zyl (310), Richter (318), Moretzsohn (319), Dettmer (323), Kovacs (324), Bardhan (345) 66.9 (SE=0.41, N=647) 78.8 (SE=0.27, N=619)
20mg od 42.4 (N=35) Van Zyl (310), Richter (318), Moretzsohn (319), Dettmer (323), Kovacs (324), Bardhan (345) 66.9 (SE=0.41, N=647) 78.8 (SE=0.27, N=619)
40mg od 43.1 (N=75) Richter (318), Moretzsohn (319), Armbrecht (321), Kovacs (324), Korner (326), Mossner (341), Van Rensburg (343), Corinaldesi (366), Koop (367), VceV (378), Dupas (379), Armstrong (391), Gillessen (388), Meneghelli (392), Labenz (384), Van Rensburg (387), Vcev (395), Pilotto (404), Bardhan (406), Zheng (421), Hein (429), Cho (430), Moraes-Filho (432) 68.9 (SE=0.15, N=4954) 84.5 (SE=0.16, N=4996)
40mg od 47.8 (N=16) Richter (318), Moretzsohn (319), Armbrecht (321), Kovacs (324), Korner (326), Mossner (341), Van Rensburg (343), Corinaldesi (366), Koop (367), VceV (378), Dupas (379), Armstrong (391), Gillessen (388), Meneghelli (392), Labenz (384), Van Rensburg (387), Vcev (395), Pilotto (404), Bardhan (406), Zheng (421), Hein (429), Cho (430), Moraes-Filho (432) 68.9 (SE=0.15, N=4954) 84.5 (SE=0.16, N=4996)
40mg od 52.5 (N=109) Richter (318), Moretzsohn (319), Armbrecht (321), Kovacs (324), Korner (326), Mossner (341), Van Rensburg (343), Corinaldesi (366), Koop (367), VceV (378), Dupas (379), Armstrong (391), Gillessen (388), Meneghelli (392), Labenz (384), Van Rensburg (387), Vcev (395), Pilotto (404), Bardhan (406), Zheng (421), Hein (429), Cho (430), Moraes-Filho (432) 68.9 (SE=0.15, N=4954) 84.5 (SE=0.16, N=4996)
40mg bid 70.8 (N=30) Madan (389) No Data 46.2 (SE=1.09, N=13)
80mg od 28.0 (N=15) Van Rensburg (343) 66.3 (SE=0.43, N=95) 86.3 (SE=0.59, N=95)
Rabeprazole
10mg od 49.7 (N=53) Cloud (385), Kinoshita 2018 89.7 (SE=0.57, N=126) 96.1 (SE=5.29, N=153)
10mg od 57.9 (N=193) Cloud (385), Kinoshita 2018 89.7 (SE=0.57, N=126) 96.1 (SE=5.29, N=153)
10mg bid 73.5 (N=44) Delchier (304) 85.4 (SE=0.55, N=103) 91.3 (SE=0.68, N=103)
20mg od 60.9 (N=169) Dekkers (303), Delchier (304), Farley (312), Adachi (328), Cloud (385), Pace (394), Holtmann (398), Pilotto (404), Pai (405) 70.9 (SE=0.82, N=804) 86.1 (SE=0.39, N=916)
40mg od 71.5 (N=16) Cloud (385), Maiti (423) 50.0 (SE=0.72, N=30) 84.6 (SE=1.07, N=26)
Rabeprazole (ER)
50mg od 81.5 (N=59) Laine (422) 52.7 (SE=0.12, N=1056) 78.4 (SE=0.15, N=1056)
Ranitidine
300mg od 36.7 (N=44) Johnson (313), Halvorse (330), Green (414) 18.7 (SE=1.71, N=438) 46.5 (SE=0.48, N=567)
150mg qid 38.0 (N=27) Farley (312), McCarty-Dawson (317), Roufail (333), Silver (342), Euler (348) 41.4 (SE=0.30, N=874) 63.6 (SE=0.28, N=874)
Tegoprazan
50mg od 68.2 (N=8) Lee 2019 87.0 (SE=0.58, N=100) 95.0 (SE=0.90, N=100)
100mg od 70.4 (N=6) Lee 2019 90.2 (SE=0.65, N=102) 95.1 (SE=0.90, N=102)
Vonoprazan
10mg od 64.7 (N=28) Ashida 2015, Okanobu 2021 86.7 (SE=2.78, N=181) 87.6 (SE=0.49, N=145)
20mg od 88.2 (N=95) Xiao 2020, Ashida 2015, Okanobu 2021, Ashida 2016 91.0 (SE=1.05, N=642) 93.9 (SE=1.86, N=605)
40mg od 96.6 (N=18) Ashida 2015 89.0 (SE=0.52, N=146) 89.0 (SE=0.52, N=146)