Diferencias estructurales en el volumen hipocampal
Characteristic agt, N = 511 control, N = 361 p-value2 q-value3 ES (90% CI)4
left_CA1 0.85 (0.76, 0.91) 0.89 (0.78, 0.94) 0.3 0.6 -0.21 (-0.58, 0.16)
left_CA2 0.018 (0.014, 0.021) 0.017 (0.014, 0.021) 0.8 0.8 0.22 (-0.15, 0.59)
left_DG 0.49 (0.42, 0.51) 0.53 (0.47, 0.58) 0.007 0.14 -0.56 (-0.94, -0.19)
left_CA3 0.041 (0.033, 0.053) 0.043 (0.037, 0.053) 0.8 0.8 0.06 (-0.31, 0.43)
left_misc 0.15 (0.11, 0.23) 0.11 (0.09, 0.19) 0.031 0.14 0.38 (0.01, 0.75)
left_SUB 0.37 (0.32, 0.39) 0.35 (0.32, 0.37) 0.3 0.6 0.31 (-0.06, 0.68)
left_ERC 0.43 (0.40, 0.46) 0.44 (0.39, 0.47) 0.5 0.6 -0.04 (-0.40, 0.33)
left_BA35 0.37 (0.33, 0.42) 0.40 (0.35, 0.47) 0.14 0.4 -0.37 (-0.74, 0.00)
left_BA36 1.45 (1.28, 1.55) 1.56 (1.40, 1.73) 0.028 0.14 -0.41 (-0.78, -0.04)
left_PHC 0.64 (0.55, 0.78) 0.72 (0.62, 0.78) 0.2 0.6 -0.29 (-0.66, 0.08)
left_sulcus 0.39 (0.32, 0.48) 0.45 (0.29, 0.50) 0.4 0.6 -0.12 (-0.49, 0.25)
right_CA1 0.86 (0.79, 0.95) 0.89 (0.79, 0.97) 0.4 0.6 -0.21 (-0.58, 0.16)
right_CA2 0.014 (0.012, 0.016) 0.017 (0.012, 0.018) 0.076 0.2 -0.19 (-0.56, 0.18)
right_DG 0.46 (0.40, 0.50) 0.48 (0.44, 0.54) 0.018 0.14 -0.35 (-0.72, 0.02)
right_CA3 0.054 (0.045, 0.067) 0.053 (0.039, 0.063) 0.5 0.6 0.30 (-0.07, 0.67)
right_misc 0.11 (0.09, 0.14) 0.10 (0.08, 0.11) 0.059 0.2 0.36 (-0.01, 0.73)
right_SUB 0.32 (0.29, 0.34) 0.32 (0.29, 0.34) 0.4 0.6 0.26 (-0.11, 0.63)
right_ERC 0.42 (0.38, 0.45) 0.44 (0.42, 0.48) 0.032 0.14 -0.12 (-0.49, 0.25)
right_BA35 0.38 (0.35, 0.43) 0.40 (0.36, 0.43) 0.6 0.7 -0.03 (-0.40, 0.34)
right_BA36 1.32 (1.16, 1.45) 1.37 (1.18, 1.46) 0.7 0.8 -0.07 (-0.44, 0.30)
right_PHC 0.70 (0.60, 0.77) 0.73 (0.64, 0.77) 0.3 0.6 -0.12 (-0.49, 0.25)
right_sulcus 0.35 (0.28, 0.40) 0.37 (0.30, 0.41) 0.3 0.6 -0.17 (-0.54, 0.20)
1 Median (IQR)
2 Wilcoxon rank sum exact test; Wilcoxon rank sum test
3 False discovery rate correction for multiple testing
4 Cohen's D (90% CI)
Comparacion de volumenes por grupo cognitivo
Characteristic Dysexecutive TGA, N = 141 Healthy control, N = 361 nonDysexecutive TGA, N = 51 p-value2 q-value3
left_CA1 0.90 (0.86, 0.94) 0.89 (0.78, 0.94) 0.84 (0.73, 0.93) 0.7 >0.9
left_CA2 0.020 (0.017, 0.021) 0.017 (0.014, 0.021) 0.015 (0.011, 0.019) 0.5 >0.9
left_DG 0.51 (0.44, 0.56) 0.53 (0.47, 0.58) 0.49 (0.46, 0.50) 0.5 >0.9
left_CA3 0.043 (0.034, 0.060) 0.043 (0.037, 0.053) 0.042 (0.031, 0.048) 0.8 >0.9
left_misc 0.14 (0.12, 0.20) 0.11 (0.09, 0.19) 0.16 (0.13, 0.21) 0.2 >0.9
left_SUB 0.37 (0.33, 0.40) 0.35 (0.32, 0.37) 0.37 (0.35, 0.38) 0.5 >0.9
left_ERC 0.45 (0.43, 0.48) 0.44 (0.39, 0.47) 0.41 (0.39, 0.45) 0.6 >0.9
left_BA35 0.40 (0.38, 0.42) 0.40 (0.35, 0.47) 0.36 (0.33, 0.41) 0.9 >0.9
left_BA36 1.50 (1.43, 1.55) 1.56 (1.40, 1.73) 1.48 (1.32, 1.55) 0.4 >0.9
left_PHC 0.67 (0.60, 0.82) 0.72 (0.62, 0.78) 0.74 (0.62, 0.83) >0.9 >0.9
left_sulcus 0.38 (0.35, 0.51) 0.45 (0.29, 0.50) 0.35 (0.33, 0.38) 0.6 >0.9
right_CA1 0.90 (0.83, 0.96) 0.89 (0.79, 0.97) 0.85 (0.74, 0.89) 0.7 >0.9
right_CA2 0.015 (0.013, 0.015) 0.017 (0.012, 0.018) 0.013 (0.009, 0.014) 0.2 >0.9
right_DG 0.50 (0.44, 0.53) 0.48 (0.44, 0.54) 0.46 (0.39, 0.48) 0.5 >0.9
right_CA3 0.049 (0.046, 0.056) 0.053 (0.039, 0.063) 0.050 (0.039, 0.065) >0.9 >0.9
right_misc 0.12 (0.09, 0.15) 0.10 (0.08, 0.11) 0.11 (0.08, 0.14) 0.2 >0.9
right_SUB 0.34 (0.29, 0.37) 0.32 (0.29, 0.34) 0.33 (0.27, 0.35) 0.4 >0.9
right_ERC 0.45 (0.39, 0.46) 0.44 (0.42, 0.48) 0.41 (0.37, 0.42) 0.2 >0.9
right_BA35 0.42 (0.36, 0.43) 0.40 (0.36, 0.43) 0.39 (0.34, 0.43) 0.7 >0.9
right_BA36 1.35 (1.25, 1.43) 1.37 (1.18, 1.46) 1.25 (1.20, 1.31) 0.7 >0.9
right_PHC 0.73 (0.68, 0.79) 0.73 (0.64, 0.77) 0.70 (0.66, 0.73) 0.8 >0.9
right_sulcus 0.34 (0.25, 0.38) 0.37 (0.30, 0.41) 0.34 (0.26, 0.40) 0.2 >0.9
1 Median (IQR)
2 Kruskal-Wallis rank sum test
3 False discovery rate correction for multiple testing
Comparacion de volumenes por grupo cognitivo
Characteristic Amnestic TGA, N = 51 Healthy control, N = 361 nonAmnestic TGA, N = 121 p-value2 q-value3
left_CA1 0.94 (0.86, 0.94) 0.89 (0.78, 0.94) 0.87 (0.82, 0.91) 0.8 >0.9
left_CA2 0.021 (0.016, 0.022) 0.017 (0.014, 0.021) 0.018 (0.016, 0.021) 0.8 >0.9
left_DG 0.51 (0.50, 0.53) 0.53 (0.47, 0.58) 0.49 (0.43, 0.53) 0.3 0.7
left_CA3 0.041 (0.040, 0.044) 0.043 (0.037, 0.053) 0.039 (0.026, 0.057) >0.9 >0.9
left_misc 0.19 (0.15, 0.23) 0.11 (0.09, 0.19) 0.13 (0.12, 0.20) 0.2 0.7
left_SUB 0.37 (0.37, 0.39) 0.35 (0.32, 0.37) 0.37 (0.31, 0.39) 0.3 0.7
left_ERC 0.45 (0.41, 0.46) 0.44 (0.39, 0.47) 0.43 (0.41, 0.46) >0.9 >0.9
left_BA35 0.33 (0.32, 0.36) 0.40 (0.35, 0.47) 0.39 (0.37, 0.42) 0.5 0.7
left_BA36 1.54 (1.29, 1.55) 1.56 (1.40, 1.73) 1.48 (1.41, 1.59) 0.5 0.7
left_PHC 0.78 (0.74, 0.79) 0.72 (0.62, 0.78) 0.64 (0.58, 0.74) 0.4 0.7
left_sulcus 0.28 (0.25, 0.37) 0.45 (0.29, 0.50) 0.37 (0.35, 0.46) 0.5 0.7
right_CA1 0.86 (0.85, 0.88) 0.89 (0.79, 0.97) 0.88 (0.79, 0.94) 0.8 >0.9
right_CA2 0.014 (0.012, 0.015) 0.017 (0.012, 0.018) 0.014 (0.012, 0.015) 0.2 0.7
right_DG 0.47 (0.43, 0.52) 0.48 (0.44, 0.54) 0.46 (0.41, 0.51) 0.3 0.7
right_CA3 0.042 (0.037, 0.055) 0.053 (0.039, 0.063) 0.053 (0.046, 0.063) 0.9 >0.9
right_misc 0.09 (0.09, 0.11) 0.10 (0.08, 0.11) 0.13 (0.09, 0.15) 0.2 0.7
right_SUB 0.34 (0.32, 0.35) 0.32 (0.29, 0.34) 0.34 (0.29, 0.36) 0.5 0.7
right_ERC 0.42 (0.40, 0.44) 0.44 (0.42, 0.48) 0.40 (0.39, 0.45) 0.2 0.7
right_BA35 0.35 (0.34, 0.39) 0.40 (0.36, 0.43) 0.41 (0.36, 0.43) 0.7 >0.9
right_BA36 1.21 (1.14, 1.25) 1.37 (1.18, 1.46) 1.33 (1.23, 1.39) 0.4 0.7
right_PHC 0.77 (0.68, 0.79) 0.73 (0.64, 0.77) 0.70 (0.62, 0.71) 0.3 0.7
right_sulcus 0.36 (0.29, 0.38) 0.37 (0.30, 0.41) 0.34 (0.26, 0.38) 0.3 0.7
1 Median (IQR)
2 Kruskal-Wallis rank sum test
3 False discovery rate correction for multiple testing