Tabla 1. Demográficos
Characteristic Control, N = 101 HNTa, N = 101 p-value2
age_rmn 72.9 (5.5) 74.1 (5.0) 0.6
AB42 384 (52) 508 (233) 0.043
TauT 728 (634) 137 (79) <0.001
TauP 71 (13) 24 (13) <0.001
AB42_TP_index 6 (1) 21 (9) <0.001
AB42_TT_profile 0.42 (0.15) 1.26 (0.51) <0.001
1 Mean (SD)
2 Wilcoxon rank sum test; Wilcoxon rank sum exact test
Tabla 2. Comparacion de los volumenes cerebrales
Characteristic Control, N = 101 HNTa, N = 101 p-value2 q-value3
left-cerebral-white-matter 232 (45) 241 (20) 0.5 0.8
supratentorial_ventricles 49 (23) 109 (35) 0.002 0.077
left-cerebellum-white-matter 14.80 (3.25) 13.26 (1.99) 0.3 0.8
left-cerebellum-cortex 52.0 (8.1) 49.5 (5.3) 0.7 0.9
left-thalamus-proper* 6.29 (0.92) 5.91 (1.01) 0.4 0.8
left-caudate 3.29 (1.05) 3.87 (1.98) 0.3 0.7
left-putamen 4.09 (1.05) 3.66 (1.34) 0.5 0.8
left-pallidum 2.00 (0.40) 1.71 (0.48) 0.3 0.8
4th-ventricle 1.49 (0.50) 2.90 (0.80) <0.001 0.065
brain-stem 21.17 (3.04) 20.40 (2.59) 0.6 0.9
left-hippocampus 3.32 (0.76) 3.61 (0.89) 0.5 0.8
left-amygdala 1.27 (0.32) 1.46 (0.33) 0.12 0.7
csf-freesurfer 1.78 (0.59) 1.39 (0.37) 0.083 0.7
left-accumbens-area 0.30 (0.18) 0.11 (0.07) 0.016 0.3
left-ventraldc 4.38 (0.56) 3.87 (0.54) 0.15 0.7
right-cerebral-white-matter 230 (44) 241 (18) 0.5 0.8
right-cerebellum-white-matter 14.77 (2.81) 13.29 (2.27) 0.4 0.8
right-cerebellum-cortex 51.8 (6.4) 50.2 (4.9) 0.9 >0.9
right-thalamus-proper* 6.18 (1.10) 5.34 (1.01) 0.2 0.7
right-caudate 3.31 (1.12) 4.73 (1.33) 0.009 0.2
right-putamen 4.23 (0.98) 3.90 (1.20) 0.6 0.9
right-pallidum 1.87 (0.38) 1.77 (0.21) 0.4 0.8
right-hippocampus 3.40 (0.78) 3.83 (0.69) 0.2 0.7
right-amygdala 1.40 (0.36) 1.48 (0.43) 0.6 0.9
right-accumbens-area 0.38 (0.18) 0.24 (0.09) 0.083 0.7
right-ventraldc 4.29 (0.70) 3.93 (0.80) 0.4 0.8
ctx-lh-superior+transversetemporal 14.2 (3.7) 14.4 (3.9) 0.9 >0.9
ctx-lh-cingulo 11.11 (2.49) 9.29 (2.22) 0.055 0.7
ctx-lh-frontalsuperiorandmiddle 33.83 (5.06) 36.45 (2.58) 0.2 0.7
ctx-lh-superiorparietal+postcentral 17.37 (2.93) 16.74 (3.65) >0.9 >0.9
ctx-lh-inferiorparietal 16.3 (4.0) 17.3 (5.5) 0.5 0.8
ctx-lh-medialoccipital 11.48 (2.53) 10.59 (2.71) 0.5 0.8
ctx-lh-parahippocampal+fusiform+entorhinal 9.96 (1.81) 10.81 (2.71) 0.5 0.8
ctx-lh-middle+inferiortemporal+pole 20.3 (3.0) 21.2 (7.0) 0.3 0.7
ctx-lh-lateraloccipital 10.91 (2.07) 12.09 (1.57) 0.2 0.7
ctx-lh-orbitofrontal 11.81 (2.96) 11.15 (1.43) 0.15 0.7
ctx-lh-precentral+paracentral 15.95 (3.29) 15.37 (1.75) 0.2 0.7
ctx-lh-frontalinferior 9.12 (2.08) 8.36 (2.59) 0.5 0.8
ctx-lh-precuneus 7.58 (1.12) 7.93 (1.30) 0.2 0.7
ctx-lh-insula 5.32 (0.76) 4.97 (1.26) 0.8 0.9
ctx-rh-superior+transversetemporal 13.24 (2.92) 14.75 (1.70) 0.2 0.7
ctx-rh-cingulo 8.89 (2.38) 7.92 (1.66) 0.2 0.7
ctx-rh-frontalsuperiorandmiddle 37.0 (6.8) 38.9 (3.2) 0.6 0.9
ctx-rh-superiorparietal+postcentral 17.35 (3.08) 16.76 (2.72) 0.8 >0.9
ctx-rh-inferiorparietal 17.23 (3.91) 18.41 (3.43) 0.7 0.9
ctx-rh-medialoccipital 11.86 (2.23) 11.21 (2.24) 0.4 0.8
ctx-rh-parahippocampal+fusiform+entorhinal 10.24 (1.96) 11.59 (1.25) 0.12 0.7
ctx-rh-middle+inferiortemporal+pole 20.6 (4.2) 23.4 (3.1) 0.2 0.7
ctx-rh-lateraloccipital 10.81 (2.06) 12.56 (2.52) 0.12 0.7
ctx-rh-orbitofrontal 11.95 (2.98) 11.67 (0.95) 0.4 0.8
ctx-rh-precentral+paracentral 14.88 (2.81) 14.87 (1.67) 0.4 0.8
ctx-rh-frontalinferior 8.78 (2.10) 8.64 (0.75) 0.7 0.9
ctx-rh-precuneus 8.34 (1.18) 8.73 (1.15) 0.4 0.8
ctx-rh-insula 5.46 (0.86) 5.48 (0.67) >0.9 >0.9
brain 1,570 (208) 1,683 (120) 0.2 0.7
wm 513 (98) 530 (36) 0.7 0.9
gm 546 (79) 551 (54) 0.8 0.9
csf 511 (141) 602 (108) 0.3 0.7
cerebellum 133 (19) 126 (12) 0.6 0.9
bpf 1,058 (166) 1,080 (78) 0.9 >0.9
evans 0 (NA%) 0 (NA%)
gctx-lh-frontal 66 (12) 65 (7) 0.6 0.9
gctx-lh-insula 5.32 (0.76) 4.97 (1.26) 0.8 0.9
gctx-lh-occipital 22.4 (4.0) 22.7 (3.0) >0.9 >0.9
gctx-lh-parietal 57 (10) 57 (11) 0.8 0.9
gctx-lh-temporal 44 (8) 46 (12) 0.3 0.7
gctx-rh-frontal 67 (13) 67 (5) 0.8 >0.9
gctx-rh-insula 5.46 (0.86) 5.48 (0.67) >0.9 >0.9
gctx-rh-occipital 22.7 (3.9) 23.8 (4.0) 0.7 0.9
gctx-rh-parietal 58 (10) 59 (7) 0.6 0.9
gctx-rh-temporal 44.1 (8.7) 49.8 (5.0) 0.15 0.7
gctx-bilat-frontal 132 (24) 132 (12) 0.7 0.9
gctx-bilat-insula 10.79 (1.59) 10.45 (1.62) 0.7 0.9
gctx-bilat-occipital 45.1 (7.4) 46.4 (6.2) >0.9 >0.9
gctx-bilat-parietal 115 (20) 116 (17) 0.9 >0.9
gctx-bilat-temporal 89 (16) 96 (16) 0.15 0.7
1 Mean (SD); n (%)
2 Wilcoxon rank sum exact test
3 False discovery rate correction for multiple testing
Frecuencia de anormalidades en biomarcadores
Characteristic N = 101
abnormal_AB42 6 (60%)
abnormal_TauP 1 (10%)
abnormal_TauT 0 (0%)
abnormal_index_AB_TP 2 (22%)
Unknown 1
abnormal_profile 4 (40%)
1 n (%)

Correlaciones entre volumen y biomarcadores

Valores de P

correlaciones$P
##                                   AB42       TauT         TauP AB42_TP_index
## AB42                                NA 0.47332839 3.839841e-01  5.608974e-04
## TauT                      0.4733283855         NA 3.086756e-02  6.599527e-02
## TauP                      0.3839841221 0.03086756           NA  2.042391e-05
## AB42_TP_index             0.0005608974 0.06599527 2.042391e-05            NA
## abnormal_profile          0.0006397043 0.09169178 1.465362e-02  4.809820e-05
## supratentorial_ventricles 0.2549816325 0.12282669 6.391542e-04  2.283065e-04
## 4th-ventricle             0.9236937682 0.12975435 4.126481e-04  3.420667e-02
##                           abnormal_profile supratentorial_ventricles
## AB42                          0.0006397043              0.2549816325
## TauT                          0.0916917849              0.1228266900
## TauP                          0.0146536199              0.0006391542
## AB42_TP_index                 0.0000480982              0.0002283065
## abnormal_profile                        NA              0.0360297459
## supratentorial_ventricles     0.0360297459                        NA
## 4th-ventricle                 0.3432223632              0.0010851491
##                           4th-ventricle
## AB42                       0.9236937682
## TauT                       0.1297543507
## TauP                       0.0004126481
## AB42_TP_index              0.0342066720
## abnormal_profile           0.3432223632
## supratentorial_ventricles  0.0010851491
## 4th-ventricle                        NA

Valores de R

correlaciones$r
##                                  AB42       TauT       TauP AB42_TP_index
## AB42                       1.00000000 -0.1701220 -0.2058237     0.7163024
## TauT                      -0.17012203  1.0000000  0.4833029    -0.4301894
## TauP                      -0.20582374  0.4833029  1.0000000    -0.8160583
## AB42_TP_index              0.71630243 -0.4301894 -0.8160583     1.0000000
## abnormal_profile          -0.69686102  0.3871781  0.5368861    -0.7946825
## supratentorial_ventricles  0.28309690 -0.3771844 -0.7264690     0.7790391
## 4th-ventricle              0.02431871 -0.3708533 -0.7428715     0.5154406
##                           abnormal_profile supratentorial_ventricles
## AB42                            -0.6968610                 0.2830969
## TauT                             0.3871781                -0.3771844
## TauP                             0.5368861                -0.7264690
## AB42_TP_index                   -0.7946825                 0.7790391
## abnormal_profile                 1.0000000                -0.4966433
## supratentorial_ventricles       -0.4966433                 1.0000000
## 4th-ventricle                   -0.2372216                 0.7049876
##                           4th-ventricle
## AB42                         0.02431871
## TauT                        -0.37085334
## TauP                        -0.74287148
## AB42_TP_index                0.51544063
## abnormal_profile            -0.23722163
## supratentorial_ventricles    0.70498760
## 4th-ventricle                1.00000000

Valores ajustados

base$AB42_ventr<-base$AB42/base$supratentorial_ventricles
base$TauT_ventr<-base$TauT/base$supratentorial_ventricles
base$TauP_ventr<-base$TauP/base$supratentorial_ventricles
base$AB42_TP_index_ventr<-base$AB42_TP_index/base$supratentorial_ventricles
base$AB42_TT_profile_ventr<-base$AB42_TT_profile/base$supratentorial_ventricles

base %>% select(AB42_ventr, 
                TauT_ventr, 
                TauP_ventr, 
                AB42_TP_index_ventr,AB42_TT_profile_ventr, Dx) %>% 
  tbl_summary(by=Dx, statistic = list(all_continuous() ~ "{mean} ({sd})"), missing="no")%>%
  add_p()
Characteristic Control, N = 101 HNTa, N = 101 p-value2
AB42_ventr 10.6 (6.8) 4.3 (1.8) 0.003
TauT_ventr 18 (15) 1 (1) <0.001
TauP_ventr 2.03 (1.53) 0.26 (0.17) <0.001
AB42_TP_index_ventr 0.15 (0.10) 0.19 (0.07) 0.3
AB42_TT_profile_ventr 0.012 (0.010) 0.011 (0.004) 0.6
1 Mean (SD)
2 Wilcoxon rank sum exact test