Karl Autopsy Analysis
Table 1
Â
| No (N=4788) |
Yes (N=921) |
Overall (N=5709) |
|
|---|---|---|---|
| Cohort | |||
| Original | 2022 (42.2%) | 537 (58.3%) | 2559 (44.8%) |
| Expansion | 597 (12.5%) | 210 (22.8%) | 807 (14.1%) |
| Replacement | 2169 (45.3%) | 174 (18.9%) | 2343 (41.0%) |
| Gender | |||
| Female | 2776 (58.0%) | 538 (58.4%) | 3314 (58.0%) |
| Male | 2012 (42.0%) | 383 (41.6%) | 2395 (42.0%) |
| Age at Death | |||
| Mean (SD) | 87.0 (7.15) | 89.4 (6.62) | 87.7 (7.09) |
| Median [Min, Max] | 87.6 [66.4, 108] | 90.0 [68.9, 106] | 88.2 [66.4, 108] |
| Missing | 2325 (48.6%) | 0 (0%) | 2325 (40.7%) |
| Race | |||
| White | 4231 (88.4%) | 865 (93.9%) | 5096 (89.3%) |
| Black | 195 (4.1%) | 12 (1.3%) | 207 (3.6%) |
| Asian | 0 (0%) | 0 (0%) | 0 (0%) |
| American Indian or Alaskan Native | 0 (0%) | 0 (0%) | 0 (0%) |
| Native Hawaiian or Pacific Islander | 3 (0.1%) | 0 (0%) | 3 (0.1%) |
| Other including mixed | 159 (3.3%) | 27 (2.9%) | 186 (3.3%) |
| Missing | 200 (4.2%) | 17 (1.8%) | 217 (3.8%) |
| Dementia Status | |||
| No Dementia | 3868 (80.8%) | 501 (54.4%) | 4369 (76.5%) |
| Dementia | 920 (19.2%) | 420 (45.6%) | 1340 (23.5%) |
| APOE Status | |||
| - APOE e4 | 2779 (58.0%) | 639 (69.4%) | 3418 (59.9%) |
| + APOE e4 | 979 (20.4%) | 245 (26.6%) | 1224 (21.4%) |
| Missing | 1030 (21.5%) | 37 (4.0%) | 1067 (18.7%) |
| Smoking Status | |||
| Never | 2374 (49.6%) | 416 (45.2%) | 2790 (48.9%) |
| Former | 2181 (45.6%) | 452 (49.1%) | 2633 (46.1%) |
| Current | 221 (4.6%) | 51 (5.5%) | 272 (4.8%) |
| Missing | 12 (0.3%) | 2 (0.2%) | 14 (0.2%) |
| Pack Years | |||
| Mean (SD) | 18.6 (47.7) | 22.2 (29.9) | 19.2 (45.3) |
| Median [Min, Max] | 0 [0, 1520] | 6.00 [0, 228] | 1.00 [0, 1520] |
| Missing | 51 (1.1%) | 5 (0.5%) | 56 (1.0%) |
| Alcohol Use | |||
| never | 858 (17.9%) | 171 (18.6%) | 1029 (18.0%) |
| previous | 1087 (22.7%) | 233 (25.3%) | 1320 (23.1%) |
| current | 2657 (55.5%) | 515 (55.9%) | 3172 (55.6%) |
| Missing | 186 (3.9%) | 2 (0.2%) | 188 (3.3%) |
| BMI | |||
| Mean (SD) | 27.5 (5.01) | 26.9 (4.84) | 27.4 (4.99) |
| Median [Min, Max] | 26.8 [14.9, 61.3] | 26.2 [15.9, 48.9] | 26.7 [14.9, 61.3] |
| Missing | 127 (2.7%) | 22 (2.4%) | 149 (2.6%) |
| Cardiovascular Disease | |||
| No | 4350 (90.9%) | 808 (87.7%) | 5158 (90.3%) |
| Yes | 397 (8.3%) | 103 (11.2%) | 500 (8.8%) |
| Missing | 41 (0.9%) | 10 (1.1%) | 51 (0.9%) |
| Hypertension | |||
| No | 2728 (57.0%) | 571 (62.0%) | 3299 (57.8%) |
| Yes | 2022 (42.2%) | 343 (37.2%) | 2365 (41.4%) |
| Missing | 38 (0.8%) | 7 (0.8%) | 45 (0.8%) |
| CASI Score (IRT) | |||
| Mean (SD) | 0.330 (0.719) | 0.322 (0.680) | 0.329 (0.713) |
| Median [Min, Max] | 0.370 [-2.69, 1.75] | 0.343 [-1.75, 1.75] | 0.366 [-2.69, 1.75] |
| Education | |||
| Less than High School | 392 (8.2%) | 67 (7.3%) | 459 (8.0%) |
| GED | 70 (1.5%) | 12 (1.3%) | 82 (1.4%) |
| High School | 1650 (34.5%) | 371 (40.3%) | 2021 (35.4%) |
| Bachelor's | 1124 (23.5%) | 230 (25.0%) | 1354 (23.7%) |
| Master's | 789 (16.5%) | 121 (13.1%) | 910 (15.9%) |
| Doctorate | 290 (6.1%) | 48 (5.2%) | 338 (5.9%) |
| Other | 471 (9.8%) | 72 (7.8%) | 543 (9.5%) |
| Missing | 2 (0.0%) | 0 (0%) | 2 (0.0%) |
| Neighborhood Median Household Income | |||
| <35,000 | 449 (9.4%) | 84 (9.1%) | 533 (9.3%) |
| 35,000-49,999 | 1430 (29.9%) | 287 (31.2%) | 1717 (30.1%) |
| 50,000-74,999 | 2231 (46.6%) | 457 (49.6%) | 2688 (47.1%) |
| >75,000 | 506 (10.6%) | 91 (9.9%) | 597 (10.5%) |
| Missing | 172 (3.6%) | 2 (0.2%) | 174 (3.0%) |
| Gross Infarcts | |||
| No | 0 (0%) | 583 (63.3%) | 583 (10.2%) |
| Yes | 0 (0%) | 266 (28.9%) | 266 (4.7%) |
| Missing | 4788 (100%) | 72 (7.8%) | 4860 (85.1%) |
| Number of Gross Infarcts | |||
| Mean (SD) | NA (NA) | 0.718 (1.53) | 0.718 (1.53) |
| Median [Min, Max] | NA [NA, NA] | 0 [0, 16.0] | 0 [0, 16.0] |
| Missing | 4788 (100%) | 72 (7.8%) | 4860 (85.1%) |
| Microinfarcts | |||
| No | 0 (0%) | 425 (46.1%) | 425 (7.4%) |
| Yes | 0 (0%) | 416 (45.2%) | 416 (7.3%) |
| Missing | 4788 (100%) | 80 (8.7%) | 4868 (85.3%) |
| Number of Microinfarcts | |||
| Mean (SD) | NA (NA) | 1.36 (2.24) | 1.36 (2.24) |
| Median [Min, Max] | NA [NA, NA] | 0 [0, 15.0] | 0 [0, 15.0] |
| Missing | 4788 (100%) | 80 (8.7%) | 4868 (85.3%) |
| Atherosclerosis | |||
| None | 0 (0%) | 36 (3.9%) | 36 (0.6%) |
| Mild | 0 (0%) | 214 (23.2%) | 214 (3.7%) |
| Moderate | 0 (0%) | 510 (55.4%) | 510 (8.9%) |
| Severe | 0 (0%) | 59 (6.4%) | 59 (1.0%) |
| Missing/unknown | 0 (0%) | 9 (1.0%) | 9 (0.2%) |
| Missing | 4788 (100%) | 93 (10.1%) | 4881 (85.5%) |
| Arteriolosclerosis | |||
| Absent | 0 (0%) | 8 (0.9%) | 8 (0.1%) |
| Mild | 0 (0%) | 172 (18.7%) | 172 (3.0%) |
| Moderate | 0 (0%) | 349 (37.9%) | 349 (6.1%) |
| Severe | 0 (0%) | 173 (18.8%) | 173 (3.0%) |
| Missing | 4788 (100%) | 219 (23.8%) | 5007 (87.7%) |
| Total Microinfarcts | |||
| Mean (SD) | NA (NA) | 1.47 (2.39) | 1.47 (2.39) |
| Median [Min, Max] | NA [NA, NA] | 1.00 [0, 17.0] | 1.00 [0, 17.0] |
| Missing | 4788 (100%) | 99 (10.7%) | 4887 (85.6%) |
| PM2.5 Exposure from Death (1 year) | |||
| Mean (SD) | 7.51 (1.47) | 7.05 (1.34) | 7.38 (1.45) |
| Median [Min, Max] | 7.39 [2.64, 12.6] | 6.85 [2.75, 11.0] | 7.21 [2.64, 12.6] |
| Missing | 2421 (50.6%) | 30 (3.3%) | 2451 (42.9%) |
| PM2.5 Exposure from Death (5 year) | |||
| Mean (SD) | 7.91 (1.59) | 7.33 (1.33) | 7.75 (1.54) |
| Median [Min, Max] | 7.90 [3.31, 13.7] | 7.05 [3.41, 11.5] | 7.63 [3.31, 13.7] |
| Missing | 2379 (49.7%) | 12 (1.3%) | 2391 (41.9%) |
| PM2.5 Exposure from Death (10 year) | |||
| Mean (SD) | 8.59 (1.97) | 7.86 (1.54) | 8.39 (1.89) |
| Median [Min, Max] | 8.38 [3.40, 16.4] | 7.68 [4.33, 13.6] | 8.20 [3.40, 16.4] |
| Missing | 2344 (49.0%) | 6 (0.7%) | 2350 (41.2%) |
| PM2.5 Exposure from Death (20 year) | |||
| Mean (SD) | 10.4 (2.54) | 9.42 (2.19) | 10.1 (2.48) |
| Median [Min, Max] | 9.97 [4.81, 18.7] | 8.85 [5.37, 16.3] | 9.62 [4.81, 18.7] |
| Missing | 2326 (48.6%) | 0 (0%) | 2326 (40.7%) |
| C_score | |||
| 0 | 0 (0%) | 187 (20.3%) | 187 (3.3%) |
| 1 | 0 (0%) | 205 (22.3%) | 205 (3.6%) |
| 2 | 0 (0%) | 198 (21.5%) | 198 (3.5%) |
| 3 | 0 (0%) | 238 (25.8%) | 238 (4.2%) |
| Missing | 4788 (100%) | 93 (10.1%) | 4881 (85.5%) |
| BRAAK | |||
| 0 | 0 (0%) | 24 (2.6%) | 24 (0.4%) |
| 1 | 0 (0%) | 68 (7.4%) | 68 (1.2%) |
| 2 | 0 (0%) | 136 (14.8%) | 136 (2.4%) |
| 3 | 0 (0%) | 142 (15.4%) | 142 (2.5%) |
| 4 | 0 (0%) | 148 (16.1%) | 148 (2.6%) |
| 5 | 0 (0%) | 173 (18.8%) | 173 (3.0%) |
| 6 | 0 (0%) | 131 (14.2%) | 131 (2.3%) |
| 98 | 0 (0%) | 1 (0.1%) | 1 (0.0%) |
| Missing | 4788 (100%) | 98 (10.6%) | 4886 (85.6%) |
| amylangi_score | |||
| 0 | 0 (0%) | 526 (57.1%) | 526 (9.2%) |
| 1 | 0 (0%) | 152 (16.5%) | 152 (2.7%) |
| 2 | 0 (0%) | 145 (15.7%) | 145 (2.5%) |
| 3 | 0 (0%) | 24 (2.6%) | 24 (0.4%) |
| Missing | 4788 (100%) | 74 (8.0%) | 4862 (85.2%) |
| late_stg | |||
| 0 | 0 (0%) | 432 (46.9%) | 432 (7.6%) |
| 1 | 0 (0%) | 178 (19.3%) | 178 (3.1%) |
| 2 | 0 (0%) | 204 (22.1%) | 204 (3.6%) |
| 3 | 0 (0%) | 13 (1.4%) | 13 (0.2%) |
| Missing | 4788 (100%) | 94 (10.2%) | 4882 (85.5%) |
| thal_phase | |||
| 0 | 0 (0%) | 50 (5.4%) | 50 (0.9%) |
| 1 | 0 (0%) | 34 (3.7%) | 34 (0.6%) |
| 2 | 0 (0%) | 39 (4.2%) | 39 (0.7%) |
| 3 | 0 (0%) | 88 (9.6%) | 88 (1.5%) |
| 4 | 0 (0%) | 108 (11.7%) | 108 (1.9%) |
| 5 | 0 (0%) | 67 (7.3%) | 67 (1.2%) |
| Missing | 4788 (100%) | 535 (58.1%) | 5323 (93.2%) |
| hipscl_any | |||
| 0 | 0 (0%) | 714 (77.5%) | 714 (12.5%) |
| 1 | 0 (0%) | 115 (12.5%) | 115 (2.0%) |
| Missing | 4788 (100%) | 92 (10.0%) | 4880 (85.5%) |
| chronic_microinfarcts_num_cere | |||
| Mean (SD) | NA (NA) | 0.866 (1.79) | 0.866 (1.79) |
| Median [Min, Max] | NA [NA, NA] | 0 [0, 15.0] | 0 [0, 15.0] |
| Missing | 4788 (100%) | 80 (8.7%) | 4868 (85.3%) |
| chronic_microinfarcts_num_deep | |||
| Mean (SD) | NA (NA) | 0.498 (0.951) | 0.498 (0.951) |
| Median [Min, Max] | NA [NA, NA] | 0 [0, 6.00] | 0 [0, 6.00] |
| Missing | 4788 (100%) | 80 (8.7%) | 4868 (85.3%) |
Outcome Plots
Exposure Plots
Green = 5 year average exposure, red = 10 year average exposure
