TEDD NPI
Karl Brown
3/17/2022
Executive Functioning
Language
Visuospatial
Memory
moca
wrat
rbans
Actigraphy data
Sleep Profiler data
NPI
UPDRS
Mayo Sleep
Table!|
Sample Sizes
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AD Group
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DLB Group
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| Predictor | N (AD) | N (DLB) | Min | Max | Mean | SD | Min | Max | Mean | SD | AUC | CI | Coefficient | P-Value | Wilcox p-value |
| Executive Functioning | |||||||||||||||
| DSF Raw (WAIS) | 7 | 7 | 6.00 | 12.00 | 9.00 | 2.38 | 4.00 | 10.00 | 7.43 | 2.15 | 0.704 | 0.414 - 0.994 | -0.34 | 0.21 | 0.22 |
| DSB Raw (WAIS) | 7 | 7 | 5.00 | 9.00 | 7.14 | 1.68 | 4.00 | 8.00 | 6.57 | 1.40 | 0.388 | 0.069 - 0.706 | -0.28 | 0.47 | 0.51 |
| DSF Scaled (WAIS) | 7 | 6 | 6.00 | 14.00 | 9.57 | 3.05 | 3.00 | 10.00 | 7.33 | 2.73 | 0.714 | 0.409 - 1 | -0.31 | 0.19 | 0.22 |
| DSB Scaled (WAIS) | 7 | 6 | 6.00 | 13.00 | 9.57 | 2.44 | 8.00 | 10.00 | 8.83 | 0.98 | 0.631 | 0.283 - 0.979 | -0.24 | 0.47 | 0.47 |
| Digit Span (RBANS) | 7 | 8 | 6.00 | 12.00 | 9.00 | 2.38 | 4.00 | 10.00 | 7.75 | 1.98 | 0.670 | 0.359 - 0.98 | -0.30 | 0.27 | 0.29 |
| Attention Index (RBANS) | 7 | 8 | 15.00 | 43.00 | 32.00 | 9.52 | 6.00 | 35.00 | 20.00 | 9.80 | 0.812 | 0.574 - 1 | -0.13 | 0.06 | 0.05 |
| Attention Standardized (RBANS) | 7 | 8 | 49.00 | 109.00 | 82.00 | 20.88 | 49.00 | 75.00 | 63.12 | 10.06 | 0.795 | 0.54 - 1 | -0.08 | 0.09 | 0.06 |
| A Seconds to Complete (Trails) | 6 | 8 | 31.14 | 150.00 | 74.44 | 49.17 | 29.62 | 150.00 | 97.44 | 46.77 | 0.677 | 0.352 - 1 | 0.01 | 0.36 | 0.30 |
| Coding (RBANS) | 7 | 8 | 9.00 | 31.00 | 23.00 | 8.19 | 0.00 | 28.00 | 12.25 | 10.22 | 0.804 | 0.573 - 1 | -0.13 | 0.07 | 0.06 |
| B Seconds to Complete (Trails) | 6 | 8 | 170.59 | 300.00 | 266.66 | 54.89 | 155.00 | 300.00 | 266.84 | 61.75 | 0.521 | 0.257 - 0.785 | 0.00 | 1.00 | 0.94 |
| Similarities Raw (WAIS) | 7 | 7 | 6.00 | 32.00 | 16.71 | 8.01 | 1.00 | 27.00 | 11.57 | 9.68 | 0.673 | 0.356 - 0.991 | -0.08 | 0.28 | 0.31 |
| Similarities Scaled (WAIS) | 7 | 7 | 3.00 | 16.00 | 8.00 | 3.96 | 1.00 | 11.00 | 4.71 | 3.95 | 0.735 | 0.447 - 1 | -0.25 | 0.16 | 0.15 |
| Matrix Reasoning Raw (WAIS) | 6 | 7 | 4.00 | 14.00 | 8.50 | 3.62 | 2.00 | 13.00 | 5.43 | 4.20 | 0.762 | 0.48 - 1 | -0.22 | 0.18 | 0.13 |
| Matrix Reasoning Scaled (WAIS) | 6 | 7 | 5.00 | 12.00 | 9.00 | 2.76 | 2.00 | 10.00 | 4.71 | 3.04 | 0.869 | 0.672 - 1 | -0.49 | 0.06 | 0.03 |
| Language | |||||||||||||||
| Picture Naming (RBANS) | 7 | 8 | 7.00 | 10.00 | 9.43 | 1.13 | 4.00 | 10.00 | 9.25 | 2.12 | 0.562 | 0.339 - 0.786 | -0.07 | 0.83 | 0.62 |
| Semantic Fluency (RBANS) | 7 | 8 | 3.00 | 17.00 | 9.00 | 5.13 | 0.00 | 16.00 | 9.25 | 4.65 | 0.545 | 0.203 - 0.887 | 0.01 | 0.92 | 0.82 |
| Language Index (RBANS) | 7 | 8 | 10.00 | 27.00 | 18.43 | 5.88 | 4.00 | 26.00 | 18.50 | 6.48 | 0.545 | 0.203 - 0.887 | 0.00 | 0.98 | 0.82 |
| Language Standardized (RBANS) | 7 | 8 | 54.00 | 103.00 | 81.14 | 14.88 | 40.00 | 92.00 | 78.12 | 16.05 | 0.509 | 0.184 - 0.834 | -0.01 | 0.69 | 1.00 |
| F Correct (PF) | 7 | 8 | 4.00 | 14.00 | 8.57 | 4.08 | 2.00 | 16.00 | 7.75 | 4.33 | 0.545 | 0.229 - 0.86 | -0.05 | 0.69 | 0.82 |
| A Correct (PF) | 6 | 7 | 3.00 | 13.00 | 8.50 | 3.45 | 0.00 | 9.00 | 4.57 | 2.70 | 0.810 | 0.534 - 1 | -0.47 | 0.08 | 0.07 |
| S Correct (PF) | 6 | 7 | 5.00 | 18.00 | 10.50 | 4.51 | 0.00 | 13.00 | 7.71 | 4.39 | 0.631 | 0.301 - 0.96 | -0.17 | 0.27 | 0.47 |
| Visuospatial | |||||||||||||||
| Line Orientation (RBANS) | 7 | 8 | 11.00 | 17.00 | 13.29 | 2.36 | 3.00 | 17.00 | 11.38 | 4.87 | 0.634 | 0.316 - 0.952 | -0.15 | 0.34 | 0.41 |
| Figure Copy (RBANS) | 7 | 8 | 14.00 | 18.00 | 15.71 | 1.80 | 8.00 | 19.00 | 12.88 | 3.44 | 0.768 | 0.52 - 1 | -0.43 | 0.11 | 0.08 |
| Visuospatial Index (RBANS) | 7 | 8 | 25.00 | 33.00 | 29.00 | 3.21 | 13.00 | 36.00 | 24.25 | 7.44 | 0.750 | 0.475 - 1 | -0.17 | 0.17 | 0.12 |
| Visuospatial Standardized (RBANS) | 7 | 8 | 69.00 | 100.00 | 82.14 | 13.59 | 50.00 | 102.00 | 68.38 | 15.36 | 0.821 | 0.571 - 1 | -0.07 | 0.12 | 0.04 |
| Block Design Raw (WAIS) | 6 | 6 | 12.00 | 33.00 | 24.17 | 6.94 | 0.00 | 28.00 | 12.00 | 11.31 | 0.819 | 0.55 - 1 | -0.15 | 0.09 | 0.08 |
| Block Design Scaled (WAIS) | 6 | 6 | 5.00 | 11.00 | 8.83 | 2.23 | 1.00 | 9.00 | 4.17 | 3.13 | 0.875 | 0.675 - 1 | -0.63 | 0.06 | 0.04 |
| Memory | |||||||||||||||
| List Learning (RBANS) | 7 | 8 | 9.00 | 25.00 | 15.71 | 4.99 | 0.00 | 24.00 | 11.62 | 7.65 | 0.714 | 0.425 - 1 | -0.11 | 0.24 | 0.18 |
| Story Memory (RBANS) | 7 | 8 | 6.00 | 18.00 | 10.86 | 4.85 | 4.00 | 21.00 | 9.12 | 5.54 | 0.625 | 0.322 - 0.928 | -0.07 | 0.50 | 0.45 |
| Immediate Memory Index (RBANS) | 7 | 8 | 21.00 | 41.00 | 26.57 | 8.04 | 4.00 | 45.00 | 20.75 | 12.44 | 0.786 | 0.502 - 1 | -0.06 | 0.30 | 0.07 |
| Immediate Memory Standardized (RBANS) | 7 | 8 | 57.00 | 100.00 | 70.71 | 17.15 | 40.00 | 94.00 | 58.88 | 18.67 | 0.804 | 0.54 - 1 | -0.04 | 0.22 | 0.05 |
| List Recall (RBANS) | 7 | 8 | 0.00 | 5.00 | 1.00 | 1.83 | 0.00 | 7.00 | 1.62 | 2.77 | 0.509 | 0.232 - 0.786 | 0.13 | 0.59 | 1.00 |
| Story Recall (RBANS) | 7 | 8 | 0.00 | 7.00 | 3.00 | 2.71 | 1.00 | 11.00 | 5.12 | 3.56 | 0.679 | 0.38 - 0.977 | 0.24 | 0.22 | 0.27 |
| Figure Recall (RBANS) | 7 | 8 | 0.00 | 14.00 | 3.00 | 5.13 | 0.00 | 14.00 | 6.00 | 6.16 | 0.625 | 0.334 - 0.916 | 0.11 | 0.31 | 0.43 |
| List Recognition (RBANS) | 7 | 8 | 13.00 | 18.00 | 14.86 | 1.68 | 11.00 | 20.00 | 14.62 | 3.02 | 0.420 | 0.113 - 0.727 | -0.04 | 0.85 | 0.64 |
| Delayed Memory Index (RBANS) | 7 | 8 | 14.00 | 44.00 | 21.86 | 10.59 | 14.00 | 50.00 | 27.38 | 14.25 | 0.643 | 0.346 - 0.94 | 0.04 | 0.39 | 0.38 |
| Delayed Memory Standardized (RBANS) | 7 | 8 | 44.00 | 94.00 | 58.00 | 16.85 | 40.00 | 101.00 | 61.12 | 22.85 | 0.527 | 0.207 - 0.847 | 0.01 | 0.75 | 0.91 |
| Other Total Scores | |||||||||||||||
| MoCA Total | 7 | 8 | 13.00 | 23.00 | 16.57 | 3.41 | 8.00 | 25.00 | 16.25 | 5.09 | 0.509 | 0.193 - 0.825 | -0.02 | 0.88 | 1.00 |
| WRAT Total | 7 | 8 | 40.00 | 67.00 | 59.86 | 9.14 | 42.00 | 67.00 | 59.25 | 9.68 | 0.562 | 0.247 - 0.878 | -0.01 | 0.89 | 0.72 |
| WRAT Total Standardized | 6 | 5 | 99.00 | 122.00 | 110.83 | 7.86 | 81.00 | 122.00 | 102.40 | 17.57 | 0.617 | 0.198 - 1 | -0.01 | 0.29 | 0.58 |
| RBANS Total Index | 7 | 8 | 107.00 | 183.00 | 127.86 | 26.82 | 44.00 | 167.00 | 110.88 | 44.08 | 0.679 | 0.354 - 1 | -0.01 | 0.37 | 0.27 |
| Actigraphy | |||||||||||||||
| Daily ENMO | 7 | 7 | 9.98 | 9.98 | 15.71 | 2.99 | 7.51 | 35.06 | 17.20 | 8.95 | 0.510 | 0.166 - 0.854 | 0.04 | 0.66 | 1.00 |
| Daily Stepcount | 7 | 7 | 2903.15 | 8459.14 | 4509.06 | 1868.14 | 953.31 | 12577.73 | 5432.09 | 3731.26 | 0.592 | 0.258 - 0.926 | 0.00 | 0.54 | 0.62 |
| Time Inactive | 7 | 7 | 671.42 | 926.97 | 756.81 | 90.92 | 451.74 | 962.07 | 722.80 | 176.77 | 0.592 | 0.242 - 0.942 | 0.00 | 0.63 | 0.62 |
| Time in Light Activity | 7 | 7 | 122.44 | 228.55 | 187.70 | 35.13 | 92.79 | 383.19 | 209.71 | 102.20 | 0.490 | 0.14 - 0.839 | 0.00 | 0.57 | 1.00 |
| Time in Moderate Activity | 7 | 7 | 11.97 | 46.35 | 22.92 | 11.91 | 3.05 | 126.23 | 35.52 | 41.44 | 0.571 | 0.237 - 0.906 | 0.02 | 0.46 | 0.71 |
| Time in Vigorous Activity | 7 | 7 | 0.00 | 0.04 | 0.01 | 0.01 | 0.00 | 0.31 | 0.10 | 0.11 | 0.765 | 0.502 - 1 | 32.41 | 0.24 | 0.10 |
| Interdaily Stability | 7 | 7 | 0.16 | 0.59 | 0.38 | 0.19 | 0.22 | 0.60 | 0.44 | 0.15 | 0.612 | 0.281 - 0.944 | 2.31 | 0.49 | 0.53 |
| Intradaily Variability | 7 | 7 | 0.76 | 1.29 | 1.03 | 0.21 | 0.61 | 1.39 | 0.87 | 0.27 | 0.714 | 0.409 - 1 | -3.20 | 0.21 | 0.21 |
| Sleep Efficiency | 7 | 7 | 0.74 | 0.86 | 0.82 | 0.05 | 0.74 | 0.95 | 0.84 | 0.07 | 0.633 | 0.311 - 0.954 | 8.78 | 0.40 | 0.46 |
| Sleep Window Duration | 7 | 7 | 3.87 | 10.44 | 7.82 | 2.18 | 2.73 | 10.03 | 7.73 | 2.55 | 0.510 | 0.172 - 0.849 | -0.02 | 0.94 | 1.00 |
| Time Asleep in Sleep Window | 7 | 7 | 3.08 | 8.80 | 6.42 | 2.02 | 1.96 | 9.47 | 6.60 | 2.51 | 0.551 | 0.212 - 0.89 | 0.04 | 0.88 | 0.80 |
| Sleep Regularity Index | 7 | 7 | 35.09 | 67.32 | 52.18 | 13.27 | 8.25 | 59.75 | 43.29 | 16.74 | 0.653 | 0.309 - 0.997 | -0.05 | 0.29 | 0.38 |
| Sleep Profiler | |||||||||||||||
| Minutes of Spindles | 7 | 7 | 0.00 | 5.03 | 1.57 | 1.98 | 0.00 | 9.90 | 1.49 | 3.71 | 0.633 | 0.312 - 0.953 | -0.01 | 0.96 | 0.43 |
| Percentage in REM | 7 | 7 | 12.20 | 22.59 | 17.13 | 4.54 | 0.00 | 13.04 | 4.52 | 5.69 | 0.918 | 0.772 - 1 | -0.82 | 0.48 | 0.01 |
| Sleep Efficiency | 7 | 7 | 0.62 | 0.91 | 0.74 | 0.11 | 0.37 | 0.91 | 0.72 | 0.18 | 0.510 | 0.161 - 0.86 | -1.06 | 0.78 | 1.00 |
| Percentage Non-REM Hypertonia | 7 | 7 | 0.00 | 11.65 | 4.76 | 4.57 | 1.06 | 20.40 | 11.12 | 6.31 | 0.816 | 0.576 - 1 | 0.22 | 0.08 | 0.06 |
| Percentage AN3 | 7 | 7 | 0.00 | 15.29 | 2.95 | 5.51 | 0.30 | 15.40 | 6.18 | 6.63 | 0.694 | 0.395 - 0.992 | 0.10 | 0.32 | 0.26 |
| Sleep Time | 7 | 7 | 4.90 | 8.31 | 6.13 | 1.18 | 2.40 | 8.21 | 5.93 | 1.78 | 0.541 | 0.196 - 0.886 | -0.10 | 0.79 | 0.85 |
| NPI | |||||||||||||||
| Delusions | 7 | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.57 | 0.53 | 0.786 | 0.588 - 0.984 | 19.41 | 1.00 | 0.03 |
| Hallucinations | 7 | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.71 | 0.49 | 0.857 | 0.676 - 1 | 20.82 | 1.00 | 0.01 |
| Anxiety | 7 | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.71 | 0.49 | 0.857 | 0.676 - 1 | 20.82 | 1.00 | 0.01 |
| Apathy | 7 | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.71 | 0.49 | 0.857 | 0.676 - 1 | 20.82 | 1.00 | 0.01 |
| Delusions or Hallucinations | 7 | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.71 | 0.49 | 0.857 | 0.676 - 1 | 20.82 | 1.00 | 0.01 |
| Sum of NPI Vars | 7 | 7 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 4.00 | 2.71 | 1.25 | 1.000 | 1 - 1 | 47.32 | 1.00 | 0.00 |
| UPDRS/Mayo | |||||||||||||||
| UPDRS Total | 5 | 7 | 0.00 | 4.00 | 2.40 | 1.82 | 6.00 | 23.00 | 12.29 | 5.79 | 1.000 | 1 - 1 | 22.15 | 1.00 | 0.01 |
| Acts Out Dreams (Mayo) | 7 | 7 | 0.00 | 1.00 | 0.14 | 0.38 | 1.00 | 1.00 | 1.00 | 0.00 | 0.929 | 0.789 - 1 | 22.51 | 1.00 | 0.00 |
wais
Comparison of roc confidence interval choices
Boxplot Figures
Comparing Baseline and 6 month for NPI
Merging to get all data into one dataframe
forward stepwise regression
LASSO
Random Forest
3d scatterplots 
Pairs plots
pairs(~ MatrixReasoning_Scaled + BlockDesign_Scaled + ACorrect, data = comp2,
col = c("red", "cornflowerblue")[comp2$Status],
pch = c(8),
labels = c("Matrix Reasoning", "Block Design", "A Correct"))
pairs(~ counts_scaled + BlockDesign_Scaled + IV_intradailyvariability, data = comp2,
col = c("red", "cornflowerblue")[comp2$Status],
pch = c(8),
labels = c("Activity Counts", "Block Design", "Intradaily Variability"))
pairs(~ MatrixReasoning_Scaled + BlockDesign_Scaled + ImmediateMemory_Standardized, data = comp2,
col = c("red", "cornflowerblue")[comp2$Status],
pch = c(8),
labels = c("Matrix Reasoning", "Block Design", "Immediate Memory"))