Table 1.

Demographics features

Characteristic	Overall, N = 578¹	CDIE, N = 188¹	EAD, N = 239¹	IAD, N = 151¹	p-value²

Gender					0.2
Female	244 / 578 (42%)	70 / 188 (37%)	103 / 239 (43%)	71 / 151 (47%)
Male	334 / 578 (58%)	118 / 188 (63%)	136 / 239 (57%)	80 / 151 (53%)
Age	46 (12)	45 (12)	47 (12)	44 (13)	0.2
Risk Factors
Hypertension	171 / 578 (30%)	58 / 188 (31%)	68 / 239 (28%)	45 / 151 (30%)	0.9
Diabetes	24 / 578 (4.2%)	10 / 188 (5.3%)	10 / 239 (4.2%)	4 / 151 (2.6%)	0.5
Dislypidemia	160 / 578 (28%)	49 / 188 (26%)	69 / 239 (29%)	42 / 151 (28%)	0.8
Never smoking	322 / 578 (56%)	117 / 188 (62%)	126 / 239 (53%)	79 / 151 (52%)	0.090
Ever smoking	100 / 578 (17%)	24 / 188 (13%)	47 / 239 (20%)	29 / 151 (19%)	0.13
Smoking	117 / 578 (20%)	41 / 188 (22%)	41 / 239 (17%)	35 / 151 (23%)	0.3
Migraine	115 / 578 (20%)	34 / 188 (18%)	54 / 239 (23%)	27 / 151 (18%)	0.4
Carotid atherosclerortic disease	23 / 578 (4.0%)	3 / 188 (1.6%)	12 / 239 (5.0%)	8 / 151 (5.3%)	0.12
Fybromuscular dysplasia	51 / 578 (8.8%)	18 / 188 (9.6%)	21 / 239 (8.8%)	12 / 151 (7.9%)	0.9
Oral contraceptives	22 / 577 (3.8%)	7 / 187 (3.7%)	10 / 239 (4.2%)	5 / 151 (3.3%)	>0.9
Thrombophilia	20 / 577 (3.5%)	11 / 187 (5.9%)	6 / 239 (2.5%)	3 / 151 (2.0%)	0.086
Cardiovascular disease	39 / 578 (6.7%)	8 / 188 (4.3%)	19 / 239 (7.9%)	12 / 151 (7.9%)	0.3
Triggers
Trigger					0.3
Major trauma	40 / 578 (6.9%)	8 / 188 (4.3%)	22 / 239 (9.2%)	10 / 151 (6.6%)
Spontaneous	350 / 578 (61%)	112 / 188 (60%)	143 / 239 (60%)	95 / 151 (63%)
Trivial trauma	188 / 578 (33%)	68 / 188 (36%)	74 / 239 (31%)	46 / 151 (30%)
¹ n / N (%); Mean (SD) ² Pearson's Chi-squared test; Kruskal-Wallis rank sum test

Table 2

Clinical presentation by intra or extracranial territory

Characteristic	Overall, N = 578¹	CDIE, N = 188¹	EAD, N = 239¹	IAD, N = 151¹	p-value²
Cerebrovascular event
IPH	8 / 577 (1.4%)	2 / 188 (1.1%)	3 / 238 (1.3%)	3 / 151 (2.0%)
No	125 / 577 (22%)	33 / 188 (18%)	59 / 238 (25%)	33 / 151 (22%)
SAH	7 / 577 (1.2%)	1 / 188 (0.5%)	1 / 238 (0.4%)	5 / 151 (3.3%)
Stroke	362 / 577 (63%)	133 / 188 (71%)	137 / 238 (58%)	92 / 151 (61%)
TIA	75 / 577 (13%)	19 / 188 (10%)	38 / 238 (16%)	18 / 151 (12%)
Local symptoms	408 / 576 (71%)	141 / 187 (75%)	157 / 238 (66%)	110 / 151 (73%)	0.086
Horner`s syndrome	116 / 576 (20%)	44 / 187 (24%)	42 / 238 (18%)	30 / 151 (20%)	0.3
Cervical pain	160 / 576 (28%)	54 / 187 (29%)	65 / 238 (27%)	41 / 151 (27%)	>0.9
Headache	311 / 576 (54%)	109 / 187 (58%)	121 / 238 (51%)	81 / 151 (54%)	0.3
Tinnitus	71 / 576 (12%)	16 / 187 (8.6%)	38 / 238 (16%)	17 / 151 (11%)	0.063
Cranial nerve palsy	124 / 574 (22%)	35 / 186 (19%)	48 / 237 (20%)	41 / 151 (27%)	0.15
¹ n / N (%) ² Pearson's Chi-squared test

Table 2b

Clinical presentation by intra or extracranial territory

Characteristic	Overall, N = 578¹	CDIE, N = 188¹	EAD, N = 239¹	IAD, N = 151¹	p-value²
Cerebrovascular event
IPH	8 / 577 (1.4%)	2 / 188 (1.1%)	3 / 238 (1.3%)	3 / 151 (2.0%)
No	125 / 577 (22%)	33 / 188 (18%)	59 / 238 (25%)	33 / 151 (22%)
SAH	7 / 577 (1.2%)	1 / 188 (0.5%)	1 / 238 (0.4%)	5 / 151 (3.3%)
Stroke	362 / 577 (63%)	133 / 188 (71%)	137 / 238 (58%)	92 / 151 (61%)
TIA	75 / 577 (13%)	19 / 188 (10%)	38 / 238 (16%)	18 / 151 (12%)
Local symptoms	408 / 576 (71%)	141 / 187 (75%)	157 / 238 (66%)	110 / 151 (73%)	0.086
Horner`s syndrome	116 / 576 (20%)	44 / 187 (24%)	42 / 238 (18%)	30 / 151 (20%)	0.3
Cervical pain	160 / 576 (28%)	54 / 187 (29%)	65 / 238 (27%)	41 / 151 (27%)	>0.9
Headache	311 / 576 (54%)	109 / 187 (58%)	121 / 238 (51%)	81 / 151 (54%)	0.3
Tinnitus	71 / 576 (12%)	16 / 187 (8.6%)	38 / 238 (16%)	17 / 151 (11%)	0.063
Cranial nerve palsy	124 / 574 (22%)	35 / 186 (19%)	48 / 237 (20%)	41 / 151 (27%)	0.15
¹ n / N (%) ² Pearson's Chi-squared test

Table 2c

Clinical presentation by intra or extracranial location and anterior/posterior territory

Characteristic	Anterior Territory					Posterior Territory					Anterior-Posterior Territory
Characteristic	Overall, N = 365¹	CDIE, N = 124¹	EAD, N = 161¹	IAD, N = 80¹	p-value²	Overall, N = 209¹	CDIE, N = 61¹	EAD, N = 77¹	IAD, N = 71¹	p-value³	Overall, N = 4¹	CDIE, N = 3¹	EAD, N = 1¹	p-value⁴
Cerebrovascular event										0.5				0.5
IPH	5 / 364 (1.4%)	1 / 124 (0.8%)	3 / 160 (1.9%)	1 / 80 (1.2%)		3 / 209 (1.4%)	1 / 61 (1.6%)	0 / 77 (0%)	2 / 71 (2.8%)
No	105 / 364 (29%)	26 / 124 (21%)	52 / 160 (32%)	27 / 80 (34%)		19 / 209 (9.1%)	6 / 61 (9.8%)	7 / 77 (9.1%)	6 / 71 (8.5%)		1 / 4 (25%)	1 / 3 (33%)	0 / 1 (0%)
SAH	3 / 364 (0.8%)	0 / 124 (0%)	0 / 160 (0%)	3 / 80 (3.8%)		4 / 209 (1.9%)	1 / 61 (1.6%)	1 / 77 (1.3%)	2 / 71 (2.8%)
Stroke	197 / 364 (54%)	81 / 124 (65%)	80 / 160 (50%)	36 / 80 (45%)		163 / 209 (78%)	50 / 61 (82%)	57 / 77 (74%)	56 / 71 (79%)		2 / 4 (50%)	2 / 3 (67%)	0 / 1 (0%)
TIA	54 / 364 (15%)	16 / 124 (13%)	25 / 160 (16%)	13 / 80 (16%)		20 / 209 (9.6%)	3 / 61 (4.9%)	12 / 77 (16%)	5 / 71 (7.0%)		1 / 4 (25%)	0 / 3 (0%)	1 / 1 (100%)
Local symptoms	247 / 363 (68%)	90 / 123 (73%)	102 / 160 (64%)	55 / 80 (69%)	0.2	159 / 209 (76%)	50 / 61 (82%)	54 / 77 (70%)	55 / 71 (77%)	0.3	2 / 4 (50%)	1 / 3 (33%)	1 / 1 (100%)	>0.9
Horner`s syndrome	96 / 363 (26%)	37 / 123 (30%)	37 / 160 (23%)	22 / 80 (28%)	0.4	19 / 209 (9.1%)	6 / 61 (9.8%)	5 / 77 (6.5%)	8 / 71 (11%)	0.6	1 / 4 (25%)	1 / 3 (33%)	0 / 1 (0%)	>0.9
Cervical pain	87 / 363 (24%)	31 / 123 (25%)	37 / 160 (23%)	19 / 80 (24%)	>0.9	72 / 209 (34%)	23 / 61 (38%)	27 / 77 (35%)	22 / 71 (31%)	0.7	1 / 4 (25%)	0 / 3 (0%)	1 / 1 (100%)	0.2
Headache	185 / 363 (51%)	68 / 123 (55%)	76 / 160 (48%)	41 / 80 (51%)	0.4	125 / 209 (60%)	41 / 61 (67%)	44 / 77 (57%)	40 / 71 (56%)	0.4	1 / 4 (25%)	0 / 3 (0%)	1 / 1 (100%)	0.2
Tinnitus	43 / 363 (12%)	9 / 123 (7.3%)	25 / 160 (16%)	9 / 80 (11%)	0.10	27 / 209 (13%)	7 / 61 (11%)	12 / 77 (16%)	8 / 71 (11%)	0.7	1 / 4 (25%)	0 / 3 (0%)	1 / 1 (100%)	0.2
Cranial nerve palsy	71 / 363 (20%)	20 / 123 (16%)	34 / 160 (21%)	17 / 80 (21%)	0.5	52 / 207 (25%)	14 / 60 (23%)	14 / 76 (18%)	24 / 71 (34%)	0.093	1 / 4 (25%)	1 / 3 (33%)	0 / 1 (0%)	>0.9
¹ n / N (%) ² Pearson's Chi-squared test ³ Fisher's exact test; Pearson's Chi-squared test ⁴ Fisher's exact test

Table 3

Disecction pattern

Characteristic	Overall, N = 578¹	CDIE, N = 188¹	EAD, N = 239¹	IAD, N = 151¹	p-value²
Pattern					0.002
Dissecting aneurysm	62 / 539 (12%)	11 / 177 (6.2%)	29 / 216 (13%)	22 / 146 (15%)
Flap	40 / 539 (7.4%)	7 / 177 (4.0%)	17 / 216 (7.9%)	16 / 146 (11%)
Occlusion	192 / 539 (36%)	82 / 177 (46%)	66 / 216 (31%)	44 / 146 (30%)
Stenosis	245 / 539 (45%)	77 / 177 (44%)	104 / 216 (48%)	64 / 146 (44%)
¹ n / N (%) ² Pearson's Chi-squared test

library('fastDummies')

base <- dummy_cols(base, select_columns = 'Pattern')

base %>% select(`Pattern_Dissecting aneurysm`,Pattern_Flap, Pattern_Occlusion, Pattern_Stenosis, Territory) %>% tbl_summary(by=Territory, missing = "no",statistic = list(all_continuous() ~ "{mean} ({sd})", all_categorical() ~ "{n} / {N} ({p}%)")) %>%
  italicize_labels()%>% add_overall() %>%add_p()

## 1 observations missing `Territory` have been removed. To include these observations, use `forcats::fct_explicit_na()` on `Territory` column before passing to `tbl_summary()`.

Characteristic	Overall, N = 578¹	CDIE, N = 188¹	EAD, N = 239¹	IAD, N = 151¹	p-value²
Pattern_Dissecting aneurysm	62 / 539 (12%)	11 / 177 (6.2%)	29 / 216 (13%)	22 / 146 (15%)	0.024
Pattern_Flap	40 / 539 (7.4%)	7 / 177 (4.0%)	17 / 216 (7.9%)	16 / 146 (11%)	0.055
Pattern_Occlusion	192 / 539 (36%)	82 / 177 (46%)	66 / 216 (31%)	44 / 146 (30%)	0.001
Pattern_Stenosis	245 / 539 (45%)	77 / 177 (44%)	104 / 216 (48%)	64 / 146 (44%)	0.6
¹ n / N (%) ² Pearson's Chi-squared test

Table 3b

Clinical presentation by disecction pattern

Characteristic	Overall, N = 540¹	Dissecting aneurysm, N = 62¹	Flap, N = 40¹	Occlusion, N = 192¹	Stenosis, N = 246¹	p-value²
Cerebrovascular event
IPH	7 / 539 (1.3%)	2 / 62 (3.2%)	2 / 40 (5.0%)	1 / 192 (0.5%)	2 / 245 (0.8%)
No	118 / 539 (22%)	21 / 62 (34%)	13 / 40 (32%)	14 / 192 (7.3%)	70 / 245 (29%)
SAH	7 / 539 (1.3%)	5 / 62 (8.1%)	1 / 40 (2.5%)	0 / 192 (0%)	1 / 245 (0.4%)
Stroke	337 / 539 (63%)	21 / 62 (34%)	19 / 40 (48%)	160 / 192 (83%)	137 / 245 (56%)
TIA	70 / 539 (13%)	13 / 62 (21%)	5 / 40 (12%)	17 / 192 (8.9%)	35 / 245 (14%)
Local symptoms	384 / 538 (71%)	45 / 62 (73%)	25 / 40 (62%)	119 / 190 (63%)	195 / 246 (79%)	0.001
Horner`s syndrome	108 / 538 (20%)	7 / 62 (11%)	11 / 40 (28%)	23 / 190 (12%)	67 / 246 (27%)	<0.001
Cervical pain	150 / 538 (28%)	16 / 62 (26%)	13 / 40 (32%)	42 / 190 (22%)	79 / 246 (32%)	0.12
Headache	296 / 538 (55%)	35 / 62 (56%)	16 / 40 (40%)	91 / 190 (48%)	154 / 246 (63%)	0.004
Tinnitus	70 / 538 (13%)	7 / 62 (11%)	5 / 40 (12%)	20 / 190 (11%)	38 / 246 (15%)	0.5
Cranial nerve palsy	120 / 537 (22%)	13 / 62 (21%)	8 / 40 (20%)	39 / 190 (21%)	60 / 245 (24%)	0.8
¹ n / N (%) ² Pearson's Chi-squared test

library('fastDummies')

base <- dummy_cols(base, select_columns = 'Pattern')

base %>% select(`Pattern_Dissecting aneurysm`,Pattern_Flap, Pattern_Occlusion, Pattern_Stenosis, Territory) %>% tbl_summary(by=Territory, missing = "no",statistic = list(all_continuous() ~ "{mean} ({sd})", all_categorical() ~ "{n} / {N} ({p}%)")) %>%
  italicize_labels()%>% add_overall() %>%add_p()

## 1 observations missing `Territory` have been removed. To include these observations, use `forcats::fct_explicit_na()` on `Territory` column before passing to `tbl_summary()`.

Characteristic	Overall, N = 578¹	CDIE, N = 188¹	EAD, N = 239¹	IAD, N = 151¹	p-value²
Pattern_Dissecting aneurysm	62 / 539 (12%)	11 / 177 (6.2%)	29 / 216 (13%)	22 / 146 (15%)	0.024
Pattern_Flap	40 / 539 (7.4%)	7 / 177 (4.0%)	17 / 216 (7.9%)	16 / 146 (11%)	0.055
Pattern_Occlusion	192 / 539 (36%)	82 / 177 (46%)	66 / 216 (31%)	44 / 146 (30%)	0.001
Pattern_Stenosis	245 / 539 (45%)	77 / 177 (44%)	104 / 216 (48%)	64 / 146 (44%)	0.6
¹ n / N (%) ² Pearson's Chi-squared test

Disseccion

Ismael calandri

30/3/2022

Table 1.

Demographics features

Table 2

Clinical presentation by intra or extracranial territory

Table 2b

Clinical presentation by intra or extracranial territory

Table 2c

Clinical presentation by intra or extracranial location and anterior/posterior territory

Table 3

Disecction pattern

Table 3b

Clinical presentation by disecction pattern