Cargo una base de datos en que ya incluà tus modelos de resultados.
dirname(rstudioapi::getActiveDocumentContext()$path)## [1] "C:/Users/CISS Fondecyt/Mi unidad/Alvacast/SISTRAT 2019 (github)/jose_stata"load(paste0(dirname(rstudioapi::getActiveDocumentContext()$path),"/imputed_ags.RData"))
print("Lista de objetos de la base")## [1] "Lista de objetos de la base"ls()## [1] "aic1" "aic2" "aic3" "aic4" "ci.boot"
## [6] "ci_gt_imp" "ci_gt_raw" "ci_tt_imp" "ci_tt_raw" "CIS1"
## [11] "CIS2" "CIS3" "cpdata" "imp" "path"
## [16] "pwp_gt_imp" "pwp_gt_imp2" "pwp_gt_imp3" "pwp_gt_raw" "pwp_tt_imp"
## [21] "pwp_tt_imp2" "pwp_tt_raw" "rfimp" "tab_int_ci"rfimp <-rfimp %>% filter(event <=3)
cpdata <- cpdata %>% filter(event <=3)
pwp_tt_raw <- coxph(Surv(tstart,tstop,status==1) ~ terap_dis + terap_dis:strata(event) + sex + edad_inicio + es_conyugal + sus
+ escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional
+ freq_cons + edad_al_ing+cluster(id)+strata(event), data = cpdata)
pwp_tt_imp <- coxph(Surv(tstart,tstop,status==1) ~ terap_dis + terap_dis:strata(event) + sex + edad_inicio + es_conyugal + sus
+ escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional
+ freq_cons + edad_al_ing+cluster(id)+strata(event), data = rfimp)#This package implements weighted estimation in Cox regression as proposed by Schemper, Wakounig and Heinze (Statistics in Medicine, 2009, doi: 10.1002/sim.3623). Weighted Cox regression provides unbiased average hazard ratio estimates also in case of non-proportional hazards. The package provides options to estimate time-dependent effects conveniently by including interactions of covariates with arbitrary functions of time, with or without making use of the weighting option. For more details we refer to Dunkler, Ploner, Schemper and Heinze (Journal of Statistical Software, 2018, doi: 10.18637/jss.v084.i02).
## ignore non-proportional hazards and apply a Cox proportional hazards model
pwp_gt_imp2 <- coxphw(Surv(tstart2,tstop2,status==1) ~ terap_dis + sex + edad_inicio + es_conyugal + sus+
escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional +
freq_cons + edad_al_ing+ cluster(id)+ strata(event), data = rfimp,template = "PH",
robust = TRUE)
pwp_tt_imp2 <- coxphw(Surv(tstart,tstop,status==1) ~ terap_dis + sex + edad_inicio + es_conyugal + sus+
escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional +
freq_cons + edad_al_ing+ cluster(id)+ strata(event), data = rfimp,template = "PH",
robust = TRUE)
pwp_gt_imp2_2 <- coxph(Surv(tstart2,tstop2,status==1) ~ terap_dis + sex + edad_inicio + es_conyugal + sus+
escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional +
freq_cons + edad_al_ing+ cluster(id)+ strata(event), data = rfimp)
pwp_tt_imp2_2 <- coxph(Surv(tstart,tstop,status==1) ~ terap_dis + sex + edad_inicio + es_conyugal + sus+
escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional +
freq_cons + edad_al_ing+ cluster(id)+ strata(event), data = rfimp)
time_before_gt_pwp<-Sys.time()
pwp_gt_imp3<-
coxphw(Surv(tstart2,tstop2,status==1) ~ terap_dis + sex + edad_inicio + es_conyugal + sus+
escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional +
freq_cons + edad_al_ing+ cluster(id)+ strata(event), data = rfimp,template="AHR", robust=T)#
time_after_gt_pwp<-Sys.time()
pwp_tt_imp3<-
coxphw(Surv(tstart,tstop,status==1) ~ terap_dis + sex + edad_inicio + es_conyugal + sus+
escolaridad + compromiso_biopsicosocial + tipo_programa + estatus_ocupacional +
freq_cons + edad_al_ing+ cluster(id)+ strata(event), data = rfimp,template="AHR", robust=T)#
time_before_tt_pwp<-Sys.time()Por ahora sólo puedo hacer los modelos con la base de datos en format Gap-Time. Pero creo que te puede servir para comparar.
res_gt_2 <- cbind.data.frame(HR=round(exp(pwp_gt_imp2$coeff),2),
Lo_ci95=round(exp(confint(pwp_gt_imp2))[,1],2),
Up_ci95=round(exp(confint(pwp_gt_imp2))[,2],2),
p=round(summary(pwp_gt_imp2)$prob,4)) %>%
data.table::data.table(keep.rownames=T)## coxphw(formula = Surv(tstart2, tstop2, status == 1) ~ terap_dis +
## sex + edad_inicio + es_conyugal + sus + escolaridad + compromiso_biopsicosocial +
## tipo_programa + estatus_ocupacional + freq_cons + edad_al_ing +
## cluster(id) + strata(event), data = rfimp, template = "PH",
## robust = TRUE)
##
## Model fitted by unweighted estimation (PH template)
##
## coef se(coef) exp(coef)
## terap_disTerapeutic discharge -9.303796e-01 1.559270e-02 0.3944040
## sexF -4.013911e-02 1.936128e-02 0.9606558
## edad_inicio -6.420303e-03 1.469675e-03 0.9936003
## es_conyugalSeparated 2.484413e-02 2.405975e-02 1.0251553
## es_conyugalSingle -7.847597e-02 1.562657e-02 0.9245243
## es_conyugalWidower -6.325706e-02 7.106618e-02 0.9387021
## susCocaine 2.080564e-01 2.158824e-02 1.2312826
## susMarijuana -7.929062e-02 3.392519e-02 0.9237714
## susOther -1.196920e-01 5.598532e-02 0.8871937
## susCocaine paste 5.078466e-01 1.812440e-02 1.6617089
## escolaridadSecundaria o menor -2.894455e-02 1.786391e-02 0.9714703
## escolaridadPrimaria o menor -1.310056e-01 2.086232e-02 0.8772128
## compromiso_biopsicosocialModerate 2.588169e-02 2.819169e-02 1.0262195
## compromiso_biopsicosocialSevere 2.092121e-01 2.999165e-02 1.2327064
## tipo_programaEM 2.900080e-01 2.410080e-02 1.3364381
## estatus_ocupacional2 -1.553299e-01 1.582076e-02 0.8561327
## estatus_ocupacional3 -7.374726e-02 1.961336e-02 0.9289064
## freq_cons2 6.024087e-02 3.125348e-02 1.0620923
## freq_cons3 1.094492e-01 3.307801e-02 1.1156634
## freq_cons4 -8.073176e-02 4.661038e-02 0.9224411
## freq_cons5 -1.206616e-01 6.269973e-02 0.8863338
## freq_cons6 2.051395e-01 3.063891e-02 1.2276963
## edad_al_ing -1.997566e-02 8.191136e-04 0.9802225
## cluster(id) -2.607135e-07 2.695216e-07 0.9999997
## strata(event)event=2 2.140712e-01 1.729171e-02 1.2387108
## strata(event)event=3 2.641735e-01 2.983954e-02 1.3023542
## lower 0.95 upper 0.95 z
## terap_disTerapeutic discharge 0.3825328 0.4066435 -59.6676514
## sexF 0.9248844 0.9978107 -2.0731641
## edad_inicio 0.9907423 0.9964665 -4.3685200
## es_conyugalSeparated 0.9779350 1.0746558 1.0326014
## es_conyugalSingle 0.8966376 0.9532782 -5.0219562
## es_conyugalWidower 0.8166504 1.0789951 -0.8901147
## susCocaine 1.1802712 1.2844988 9.6374863
## susMarijuana 0.8643454 0.9872831 -2.3372195
## susOther 0.7949936 0.9900867 -2.1379174
## susCocaine paste 1.6037159 1.7217991 28.0200517
## escolaridadSecundaria o menor 0.9380452 1.0060865 -1.6202804
## escolaridadPrimaria o menor 0.8420675 0.9138250 -6.2795324
## compromiso_biopsicosocialModerate 0.9710542 1.0845188 0.9180611
## compromiso_biopsicosocialSevere 1.1623334 1.3073402 6.9756775
## tipo_programaEM 1.2747770 1.4010818 12.0331253
## estatus_ocupacional2 0.8299930 0.8830956 -9.8181073
## estatus_ocupacional3 0.8938755 0.9653102 -3.7600526
## freq_cons2 0.9989857 1.1291855 1.9274933
## freq_cons3 1.0456279 1.1903900 3.3088216
## freq_cons4 0.8419064 1.0106795 -1.7320556
## freq_cons5 0.7838396 1.0022300 -1.9244365
## freq_cons6 1.1561416 1.3036795 6.6953898
## edad_al_ing 0.9786501 0.9817975 -24.3869295
## cluster(id) 0.9999992 1.0000003 -0.9673196
## strata(event)event=2 1.1974330 1.2814116 12.3799914
## strata(event)event=3 1.2283713 1.3807930 8.8531377
## p
## terap_disTerapeutic discharge 0.000000e+00
## sexF 3.815701e-02
## edad_inicio 1.250914e-05
## es_conyugalSeparated 3.017905e-01
## es_conyugalSingle 5.114786e-07
## es_conyugalWidower 3.734043e-01
## susCocaine 0.000000e+00
## susMarijuana 1.942777e-02
## susOther 3.252345e-02
## susCocaine paste 0.000000e+00
## escolaridadSecundaria o menor 1.051721e-01
## escolaridadPrimaria o menor 3.395928e-10
## compromiso_biopsicosocialModerate 3.585869e-01
## compromiso_biopsicosocialSevere 3.044009e-12
## tipo_programaEM 0.000000e+00
## estatus_ocupacional2 0.000000e+00
## estatus_ocupacional3 1.698776e-04
## freq_cons2 5.391819e-02
## freq_cons3 9.368950e-04
## freq_cons4 8.326366e-02
## freq_cons5 5.429990e-02
## freq_cons6 2.150979e-11
## edad_al_ing 0.000000e+00
## cluster(id) 3.333843e-01
## strata(event)event=2 0.000000e+00
## strata(event)event=3 0.000000e+00
##
## Wald Chi-square = 8582.993 on 26 df p = 0 n = 107665
##
## Covariance-Matrix:
## terap_disTerapeutic discharge sexF
## terap_disTerapeutic discharge 2.431322e-04 1.241425e-06
## sexF 1.241425e-06 3.748591e-04
## edad_inicio 1.114401e-07 -4.376844e-06
## es_conyugalSeparated 4.664309e-06 -6.058083e-06
## es_conyugalSingle 2.927242e-06 1.592277e-05
## es_conyugalWidower 2.203398e-05 -5.533280e-05
## susCocaine 6.978988e-06 4.697750e-06
## susMarijuana 4.933029e-06 1.013525e-05
## susOther -9.027691e-06 -4.523431e-05
## susCocaine paste 3.784918e-06 1.746132e-05
## escolaridadSecundaria o menor 8.218619e-06 -2.004907e-06
## escolaridadPrimaria o menor 1.873889e-05 -1.675163e-05
## compromiso_biopsicosocialModerate 1.034685e-05 -1.626069e-05
## compromiso_biopsicosocialSevere 6.079163e-06 -2.060583e-05
## tipo_programaEM -1.607304e-05 -2.685118e-04
## estatus_ocupacional2 1.055474e-06 1.759845e-05
## estatus_ocupacional3 5.771119e-07 -7.961877e-05
## freq_cons2 4.774215e-06 5.982671e-06
## freq_cons3 4.391302e-06 1.353833e-05
## freq_cons4 3.055972e-06 3.152692e-07
## freq_cons5 7.978254e-06 -4.207381e-05
## freq_cons6 8.600854e-07 1.654265e-05
## edad_al_ing -5.379606e-07 1.566781e-06
## cluster(id) 4.751224e-12 -9.851783e-12
## strata(event)event=2 5.615959e-06 -8.092360e-06
## strata(event)event=3 1.145401e-05 -2.397792e-05
## edad_inicio es_conyugalSeparated
## terap_disTerapeutic discharge 1.114401e-07 4.664309e-06
## sexF -4.376844e-06 -6.058083e-06
## edad_inicio 2.159944e-06 -7.543167e-07
## es_conyugalSeparated -7.543167e-07 5.788717e-04
## es_conyugalSingle 1.019262e-07 1.255127e-04
## es_conyugalWidower -4.480961e-06 1.701876e-04
## susCocaine -1.133373e-06 1.157922e-05
## susMarijuana 9.725400e-08 7.156861e-06
## susOther -9.503272e-06 4.786448e-06
## susCocaine paste -5.989715e-07 8.836883e-06
## escolaridadSecundaria o menor 5.469700e-07 1.821111e-05
## escolaridadPrimaria o menor 1.839315e-06 3.320628e-05
## compromiso_biopsicosocialModerate 1.388397e-06 -4.301417e-06
## compromiso_biopsicosocialSevere 2.723113e-06 -1.993346e-05
## tipo_programaEM 5.825582e-07 6.440284e-07
## estatus_ocupacional2 5.811597e-07 1.940383e-05
## estatus_ocupacional3 2.595157e-07 1.292914e-05
## freq_cons2 3.160353e-07 -1.133129e-05
## freq_cons3 7.429314e-07 -1.528888e-05
## freq_cons4 1.896892e-08 -1.245935e-05
## freq_cons5 2.399950e-06 -1.337796e-05
## freq_cons6 8.647308e-07 -1.335681e-05
## edad_al_ing -3.378798e-07 -2.482163e-06
## cluster(id) -5.835149e-12 -1.558301e-11
## strata(event)event=2 1.065896e-06 -4.786309e-06
## strata(event)event=3 1.852019e-06 8.252812e-06
## es_conyugalSingle es_conyugalWidower
## terap_disTerapeutic discharge 2.927242e-06 2.203398e-05
## sexF 1.592277e-05 -5.533280e-05
## edad_inicio 1.019262e-07 -4.480961e-06
## es_conyugalSeparated 1.255127e-04 1.701876e-04
## es_conyugalSingle 2.441898e-04 9.879379e-05
## es_conyugalWidower 9.879379e-05 5.050402e-03
## susCocaine 1.883042e-05 2.212471e-05
## susMarijuana 3.890370e-07 -1.682782e-05
## susOther 1.382019e-06 6.893711e-06
## susCocaine paste 6.299175e-06 1.404095e-05
## escolaridadSecundaria o menor 9.335437e-06 -8.063384e-06
## escolaridadPrimaria o menor 1.583694e-05 -3.351847e-05
## compromiso_biopsicosocialModerate -1.233756e-05 -9.887481e-06
## compromiso_biopsicosocialSevere -2.336654e-05 -3.067501e-05
## tipo_programaEM -8.339917e-06 1.259133e-05
## estatus_ocupacional2 3.155543e-05 9.601664e-06
## estatus_ocupacional3 1.451387e-05 -3.087947e-05
## freq_cons2 -7.006275e-06 -1.439058e-05
## freq_cons3 -7.747219e-06 -5.745538e-07
## freq_cons4 4.017300e-06 1.686803e-06
## freq_cons5 -6.599822e-06 1.227969e-05
## freq_cons6 -1.070707e-05 -1.178186e-05
## edad_al_ing 3.358866e-06 -5.428220e-06
## cluster(id) -1.102486e-11 1.401296e-10
## strata(event)event=2 -4.188667e-06 -7.337373e-06
## strata(event)event=3 -1.046338e-05 -7.940048e-06
## susCocaine susMarijuana susOther
## terap_disTerapeutic discharge 6.978988e-06 4.933029e-06 -9.027691e-06
## sexF 4.697750e-06 1.013525e-05 -4.523431e-05
## edad_inicio -1.133373e-06 9.725400e-08 -9.503272e-06
## es_conyugalSeparated 1.157922e-05 7.156861e-06 4.786448e-06
## es_conyugalSingle 1.883042e-05 3.890370e-07 1.382019e-06
## es_conyugalWidower 2.212471e-05 -1.682782e-05 6.893711e-06
## susCocaine 4.660523e-04 2.302743e-04 1.940558e-04
## susMarijuana 2.302743e-04 1.150919e-03 2.104610e-04
## susOther 1.940558e-04 2.104610e-04 3.134356e-03
## susCocaine paste 2.207209e-04 2.390441e-04 2.005844e-04
## escolaridadSecundaria o menor 5.654829e-06 9.292555e-06 3.172827e-05
## escolaridadPrimaria o menor 3.656275e-05 2.814142e-05 3.768753e-05
## compromiso_biopsicosocialModerate -2.583986e-05 2.852304e-05 -8.006107e-06
## compromiso_biopsicosocialSevere -3.981316e-05 4.058023e-05 1.373648e-06
## tipo_programaEM -8.179644e-06 -3.200031e-06 1.700059e-05
## estatus_ocupacional2 8.079679e-07 -1.153318e-06 1.993374e-05
## estatus_ocupacional3 1.134492e-05 -2.060037e-05 -1.452130e-05
## freq_cons2 8.145517e-06 6.594339e-07 2.141800e-06
## freq_cons3 7.615600e-06 -1.789521e-05 -1.423154e-05
## freq_cons4 -4.623730e-06 -9.151891e-06 4.550912e-06
## freq_cons5 -2.218960e-05 -2.444686e-05 -2.893155e-05
## freq_cons6 4.485639e-06 -5.494572e-05 -7.784725e-05
## edad_al_ing 4.208053e-06 6.410364e-06 2.332535e-06
## cluster(id) 4.198767e-11 -1.539705e-11 -1.013675e-10
## strata(event)event=2 -3.635540e-06 1.366428e-05 1.873202e-06
## strata(event)event=3 -9.513753e-06 3.306569e-06 1.960788e-05
## susCocaine paste
## terap_disTerapeutic discharge 3.784918e-06
## sexF 1.746132e-05
## edad_inicio -5.989715e-07
## es_conyugalSeparated 8.836883e-06
## es_conyugalSingle 6.299175e-06
## es_conyugalWidower 1.404095e-05
## susCocaine 2.207209e-04
## susMarijuana 2.390441e-04
## susOther 2.005844e-04
## susCocaine paste 3.284938e-04
## escolaridadSecundaria o menor -1.731368e-05
## escolaridadPrimaria o menor -9.291096e-06
## compromiso_biopsicosocialModerate -3.401016e-05
## compromiso_biopsicosocialSevere -5.686031e-05
## tipo_programaEM -1.401965e-05
## estatus_ocupacional2 3.013129e-05
## estatus_ocupacional3 1.555415e-05
## freq_cons2 7.141450e-06
## freq_cons3 -9.007018e-06
## freq_cons4 -2.607508e-05
## freq_cons5 -2.546835e-05
## freq_cons6 -2.478361e-05
## edad_al_ing 4.469506e-06
## cluster(id) -2.612066e-11
## strata(event)event=2 -2.326687e-05
## strata(event)event=3 -4.572512e-05
## escolaridadSecundaria o menor
## terap_disTerapeutic discharge 8.218619e-06
## sexF -2.004907e-06
## edad_inicio 5.469700e-07
## es_conyugalSeparated 1.821111e-05
## es_conyugalSingle 9.335437e-06
## es_conyugalWidower -8.063384e-06
## susCocaine 5.654829e-06
## susMarijuana 9.292555e-06
## susOther 3.172827e-05
## susCocaine paste -1.731368e-05
## escolaridadSecundaria o menor 3.191194e-04
## escolaridadPrimaria o menor 2.447800e-04
## compromiso_biopsicosocialModerate -1.641380e-06
## compromiso_biopsicosocialSevere -7.336770e-06
## tipo_programaEM 3.583598e-06
## estatus_ocupacional2 1.357288e-06
## estatus_ocupacional3 -3.717581e-06
## freq_cons2 -2.996815e-06
## freq_cons3 2.729868e-06
## freq_cons4 -1.106774e-05
## freq_cons5 -9.412212e-06
## freq_cons6 -2.108479e-06
## edad_al_ing 5.702077e-08
## cluster(id) -1.630515e-11
## strata(event)event=2 3.277604e-06
## strata(event)event=3 2.948884e-06
## escolaridadPrimaria o menor
## terap_disTerapeutic discharge 1.873889e-05
## sexF -1.675163e-05
## edad_inicio 1.839315e-06
## es_conyugalSeparated 3.320628e-05
## es_conyugalSingle 1.583694e-05
## es_conyugalWidower -3.351847e-05
## susCocaine 3.656275e-05
## susMarijuana 2.814142e-05
## susOther 3.768753e-05
## susCocaine paste -9.291096e-06
## escolaridadSecundaria o menor 2.447800e-04
## escolaridadPrimaria o menor 4.352366e-04
## compromiso_biopsicosocialModerate -3.565561e-06
## compromiso_biopsicosocialSevere -2.118778e-05
## tipo_programaEM 6.901027e-06
## estatus_ocupacional2 1.755969e-06
## estatus_ocupacional3 -1.684008e-05
## freq_cons2 -4.728217e-07
## freq_cons3 5.256754e-06
## freq_cons4 -9.524910e-06
## freq_cons5 -5.547302e-06
## freq_cons6 6.132574e-07
## edad_al_ing -1.082422e-06
## cluster(id) -4.788826e-11
## strata(event)event=2 1.352380e-05
## strata(event)event=3 1.968396e-05
## compromiso_biopsicosocialModerate
## terap_disTerapeutic discharge 1.034685e-05
## sexF -1.626069e-05
## edad_inicio 1.388397e-06
## es_conyugalSeparated -4.301417e-06
## es_conyugalSingle -1.233756e-05
## es_conyugalWidower -9.887481e-06
## susCocaine -2.583986e-05
## susMarijuana 2.852304e-05
## susOther -8.006107e-06
## susCocaine paste -3.401016e-05
## escolaridadSecundaria o menor -1.641380e-06
## escolaridadPrimaria o menor -3.565561e-06
## compromiso_biopsicosocialModerate 7.947715e-04
## compromiso_biopsicosocialSevere 7.364788e-04
## tipo_programaEM -7.076007e-06
## estatus_ocupacional2 2.178328e-05
## estatus_ocupacional3 1.975377e-06
## freq_cons2 -5.861989e-05
## freq_cons3 -8.524135e-05
## freq_cons4 2.339690e-05
## freq_cons5 -1.187636e-05
## freq_cons6 -8.110610e-05
## edad_al_ing -3.257193e-07
## cluster(id) 1.891911e-11
## strata(event)event=2 -5.246286e-06
## strata(event)event=3 -1.368788e-05
## compromiso_biopsicosocialSevere
## terap_disTerapeutic discharge 6.079163e-06
## sexF -2.060583e-05
## edad_inicio 2.723113e-06
## es_conyugalSeparated -1.993346e-05
## es_conyugalSingle -2.336654e-05
## es_conyugalWidower -3.067501e-05
## susCocaine -3.981316e-05
## susMarijuana 4.058023e-05
## susOther 1.373648e-06
## susCocaine paste -5.686031e-05
## escolaridadSecundaria o menor -7.336770e-06
## escolaridadPrimaria o menor -2.118778e-05
## compromiso_biopsicosocialModerate 7.364788e-04
## compromiso_biopsicosocialSevere 8.994994e-04
## tipo_programaEM -4.349845e-05
## estatus_ocupacional2 5.470849e-05
## estatus_ocupacional3 1.344640e-05
## freq_cons2 -7.095504e-05
## freq_cons3 -1.190309e-04
## freq_cons4 2.275126e-05
## freq_cons5 -2.661080e-05
## freq_cons6 -1.405750e-04
## edad_al_ing -4.916778e-07
## cluster(id) 2.142649e-11
## strata(event)event=2 -1.918525e-05
## strata(event)event=3 -3.355637e-05
## tipo_programaEM estatus_ocupacional2
## terap_disTerapeutic discharge -1.607304e-05 1.055474e-06
## sexF -2.685118e-04 1.759845e-05
## edad_inicio 5.825582e-07 5.811597e-07
## es_conyugalSeparated 6.440284e-07 1.940383e-05
## es_conyugalSingle -8.339917e-06 3.155543e-05
## es_conyugalWidower 1.259133e-05 9.601664e-06
## susCocaine -8.179644e-06 8.079679e-07
## susMarijuana -3.200031e-06 -1.153318e-06
## susOther 1.700059e-05 1.993374e-05
## susCocaine paste -1.401965e-05 3.013129e-05
## escolaridadSecundaria o menor 3.583598e-06 1.357288e-06
## escolaridadPrimaria o menor 6.901027e-06 1.755969e-06
## compromiso_biopsicosocialModerate -7.076007e-06 2.178328e-05
## compromiso_biopsicosocialSevere -4.349845e-05 5.470849e-05
## tipo_programaEM 5.808487e-04 -2.958052e-06
## estatus_ocupacional2 -2.958052e-06 2.502963e-04
## estatus_ocupacional3 -1.639849e-05 1.141177e-04
## freq_cons2 -2.244718e-05 4.472762e-06
## freq_cons3 -2.122809e-05 2.495223e-05
## freq_cons4 -1.303630e-05 -1.287086e-06
## freq_cons5 7.375474e-06 1.278786e-05
## freq_cons6 -2.838210e-05 3.787727e-05
## edad_al_ing 1.148388e-07 -7.289665e-07
## cluster(id) 5.903795e-11 -3.626247e-11
## strata(event)event=2 -9.395611e-06 9.728128e-06
## strata(event)event=3 -7.907735e-06 1.505249e-05
## estatus_ocupacional3 freq_cons2
## terap_disTerapeutic discharge 5.771119e-07 4.774215e-06
## sexF -7.961877e-05 5.982671e-06
## edad_inicio 2.595157e-07 3.160353e-07
## es_conyugalSeparated 1.292914e-05 -1.133129e-05
## es_conyugalSingle 1.451387e-05 -7.006275e-06
## es_conyugalWidower -3.087947e-05 -1.439058e-05
## susCocaine 1.134492e-05 8.145517e-06
## susMarijuana -2.060037e-05 6.594339e-07
## susOther -1.452130e-05 2.141800e-06
## susCocaine paste 1.555415e-05 7.141450e-06
## escolaridadSecundaria o menor -3.717581e-06 -2.996815e-06
## escolaridadPrimaria o menor -1.684008e-05 -4.728217e-07
## compromiso_biopsicosocialModerate 1.975377e-06 -5.861989e-05
## compromiso_biopsicosocialSevere 1.344640e-05 -7.095504e-05
## tipo_programaEM -1.639849e-05 -2.244718e-05
## estatus_ocupacional2 1.141177e-04 4.472762e-06
## estatus_ocupacional3 3.846838e-04 3.494906e-06
## freq_cons2 3.494906e-06 9.767799e-04
## freq_cons3 8.628204e-06 8.068437e-04
## freq_cons4 1.214589e-07 7.903467e-04
## freq_cons5 -1.012491e-06 7.965420e-04
## freq_cons6 1.116424e-05 8.100265e-04
## edad_al_ing -4.392867e-07 1.199508e-07
## cluster(id) -2.215823e-11 -1.471600e-11
## strata(event)event=2 4.394837e-06 1.009066e-05
## strata(event)event=3 2.275206e-06 1.430921e-05
## freq_cons3 freq_cons4 freq_cons5
## terap_disTerapeutic discharge 4.391302e-06 3.055972e-06 7.978254e-06
## sexF 1.353833e-05 3.152692e-07 -4.207381e-05
## edad_inicio 7.429314e-07 1.896892e-08 2.399950e-06
## es_conyugalSeparated -1.528888e-05 -1.245935e-05 -1.337796e-05
## es_conyugalSingle -7.747219e-06 4.017300e-06 -6.599822e-06
## es_conyugalWidower -5.745538e-07 1.686803e-06 1.227969e-05
## susCocaine 7.615600e-06 -4.623730e-06 -2.218960e-05
## susMarijuana -1.789521e-05 -9.151891e-06 -2.444686e-05
## susOther -1.423154e-05 4.550912e-06 -2.893155e-05
## susCocaine paste -9.007018e-06 -2.607508e-05 -2.546835e-05
## escolaridadSecundaria o menor 2.729868e-06 -1.106774e-05 -9.412212e-06
## escolaridadPrimaria o menor 5.256754e-06 -9.524910e-06 -5.547302e-06
## compromiso_biopsicosocialModerate -8.524135e-05 2.339690e-05 -1.187636e-05
## compromiso_biopsicosocialSevere -1.190309e-04 2.275126e-05 -2.661080e-05
## tipo_programaEM -2.122809e-05 -1.303630e-05 7.375474e-06
## estatus_ocupacional2 2.495223e-05 -1.287086e-06 1.278786e-05
## estatus_ocupacional3 8.628204e-06 1.214589e-07 -1.012491e-06
## freq_cons2 8.068437e-04 7.903467e-04 7.965420e-04
## freq_cons3 1.094155e-03 7.929965e-04 8.041381e-04
## freq_cons4 7.929965e-04 2.172527e-03 7.960638e-04
## freq_cons5 8.041381e-04 7.960638e-04 3.931256e-03
## freq_cons6 8.310833e-04 7.958580e-04 8.123415e-04
## edad_al_ing -2.491795e-07 1.586041e-07 -9.718573e-07
## cluster(id) 1.664552e-13 8.696441e-11 -1.533731e-12
## strata(event)event=2 9.824907e-06 -6.446908e-07 -3.328795e-05
## strata(event)event=3 9.735589e-06 -5.977467e-06 -3.755842e-05
## freq_cons6 edad_al_ing cluster(id)
## terap_disTerapeutic discharge 8.600854e-07 -5.379606e-07 4.751224e-12
## sexF 1.654265e-05 1.566781e-06 -9.851783e-12
## edad_inicio 8.647308e-07 -3.378798e-07 -5.835149e-12
## es_conyugalSeparated -1.335681e-05 -2.482163e-06 -1.558301e-11
## es_conyugalSingle -1.070707e-05 3.358866e-06 -1.102486e-11
## es_conyugalWidower -1.178186e-05 -5.428220e-06 1.401296e-10
## susCocaine 4.485639e-06 4.208053e-06 4.198767e-11
## susMarijuana -5.494572e-05 6.410364e-06 -1.539705e-11
## susOther -7.784725e-05 2.332535e-06 -1.013675e-10
## susCocaine paste -2.478361e-05 4.469506e-06 -2.612066e-11
## escolaridadSecundaria o menor -2.108479e-06 5.702077e-08 -1.630515e-11
## escolaridadPrimaria o menor 6.132574e-07 -1.082422e-06 -4.788826e-11
## compromiso_biopsicosocialModerate -8.110610e-05 -3.257193e-07 1.891911e-11
## compromiso_biopsicosocialSevere -1.405750e-04 -4.916778e-07 2.142649e-11
## tipo_programaEM -2.838210e-05 1.148388e-07 5.903795e-11
## estatus_ocupacional2 3.787727e-05 -7.289665e-07 -3.626247e-11
## estatus_ocupacional3 1.116424e-05 -4.392867e-07 -2.215823e-11
## freq_cons2 8.100265e-04 1.199508e-07 -1.471600e-11
## freq_cons3 8.310833e-04 -2.491795e-07 1.664552e-13
## freq_cons4 7.958580e-04 1.586041e-07 8.696441e-11
## freq_cons5 8.123415e-04 -9.718573e-07 -1.533731e-12
## freq_cons6 9.387430e-04 -9.266153e-07 1.230730e-11
## edad_al_ing -9.266153e-07 6.709470e-07 -5.756615e-13
## cluster(id) 1.230730e-11 -5.756615e-13 7.264188e-14
## strata(event)event=2 6.762130e-06 -9.416436e-07 4.198403e-11
## strata(event)event=3 1.010660e-05 -1.861774e-06 1.553978e-12
## strata(event)event=2 strata(event)event=3
## terap_disTerapeutic discharge 5.615959e-06 1.145401e-05
## sexF -8.092360e-06 -2.397792e-05
## edad_inicio 1.065896e-06 1.852019e-06
## es_conyugalSeparated -4.786309e-06 8.252812e-06
## es_conyugalSingle -4.188667e-06 -1.046338e-05
## es_conyugalWidower -7.337373e-06 -7.940048e-06
## susCocaine -3.635540e-06 -9.513753e-06
## susMarijuana 1.366428e-05 3.306569e-06
## susOther 1.873202e-06 1.960788e-05
## susCocaine paste -2.326687e-05 -4.572512e-05
## escolaridadSecundaria o menor 3.277604e-06 2.948884e-06
## escolaridadPrimaria o menor 1.352380e-05 1.968396e-05
## compromiso_biopsicosocialModerate -5.246286e-06 -1.368788e-05
## compromiso_biopsicosocialSevere -1.918525e-05 -3.355637e-05
## tipo_programaEM -9.395611e-06 -7.907735e-06
## estatus_ocupacional2 9.728128e-06 1.505249e-05
## estatus_ocupacional3 4.394837e-06 2.275206e-06
## freq_cons2 1.009066e-05 1.430921e-05
## freq_cons3 9.824907e-06 9.735589e-06
## freq_cons4 -6.446908e-07 -5.977467e-06
## freq_cons5 -3.328795e-05 -3.755842e-05
## freq_cons6 6.762130e-06 1.010660e-05
## edad_al_ing -9.416436e-07 -1.861774e-06
## cluster(id) 4.198403e-11 1.553978e-12
## strata(event)event=2 2.990031e-04 7.311040e-05
## strata(event)event=3 7.311040e-05 8.903980e-04
##
## Generalized concordance probability: Estimates may be biased!
## concordance prob. lower 0.95 upper 0.95
## terap_disTerapeutic discharge 0.2828 0.2767 0.2891
## sexF 0.4900 0.4805 0.4995
## edad_inicio 0.4984 0.4977 0.4991
## es_conyugalSeparated 0.5062 0.4944 0.5180
## es_conyugalSingle 0.4804 0.4728 0.4880
## es_conyugalWidower 0.4842 0.4495 0.5190
## susCocaine 0.5518 0.5413 0.5623
## susMarijuana 0.4802 0.4636 0.4968
## susOther 0.4701 0.4429 0.4975
## susCocaine paste 0.6243 0.6159 0.6326
## escolaridadSecundaria o menor 0.4928 0.4840 0.5015
## escolaridadPrimaria o menor 0.4673 0.4571 0.4775
## compromiso_biopsicosocialModerate 0.5065 0.4927 0.5203
## compromiso_biopsicosocialSevere 0.5521 0.5375 0.5666
## tipo_programaEM 0.5720 0.5604 0.5835
## estatus_ocupacional2 0.4612 0.4535 0.4690
## estatus_ocupacional3 0.4816 0.4720 0.4912
## freq_cons2 0.5151 0.4997 0.5303
## freq_cons3 0.5273 0.5112 0.5435
## freq_cons4 0.4798 0.4571 0.5027
## freq_cons5 0.4699 0.4394 0.5006
## freq_cons6 0.5511 0.5362 0.5659
## edad_al_ing 0.4950 0.4946 0.4954
## cluster(id) 0.5000 0.5000 0.5000
## strata(event)event=2 0.5533 0.5449 0.5617
## strata(event)event=3 0.5657 0.5512 0.5800res_gt_3 <- cbind.data.frame(Avg_HR=round(exp(pwp_gt_imp3$coeff),2),
Lo_ci95=round(exp(confint(pwp_gt_imp3))[,1],2),
Up_ci95=round(exp(confint(pwp_gt_imp3))[,2],2),
p=round(summary(pwp_gt_imp3)$prob,4))%>%
data.table::data.table(keep.rownames=T)## coxphw(formula = Surv(tstart2, tstop2, status == 1) ~ terap_dis +
## sex + edad_inicio + es_conyugal + sus + escolaridad + compromiso_biopsicosocial +
## tipo_programa + estatus_ocupacional + freq_cons + edad_al_ing +
## cluster(id) + strata(event), data = rfimp, template = "AHR",
## robust = T)
##
## Model fitted by weighted estimation (AHR template)
##
## coef se(coef) exp(coef)
## terap_disTerapeutic discharge -5.382080e-01 2.897133e-02 0.5837935
## sexF -4.218219e-02 3.937751e-02 0.9586951
## edad_inicio -5.341654e-03 2.627356e-03 0.9946726
## es_conyugalSeparated 4.002348e-02 4.575620e-02 1.0408352
## es_conyugalSingle -8.872040e-02 3.044433e-02 0.9151014
## es_conyugalWidower 1.445425e-01 1.126878e-01 1.1555108
## susCocaine 2.009029e-01 4.091460e-02 1.2225060
## susMarijuana -4.883129e-02 6.603844e-02 0.9523418
## susOther -2.562880e-01 1.158125e-01 0.7739191
## susCocaine paste 4.680864e-01 3.670060e-02 1.5969354
## escolaridadSecundaria o menor -1.028077e-01 3.326375e-02 0.9023005
## escolaridadPrimaria o menor -1.791014e-01 3.585379e-02 0.8360211
## compromiso_biopsicosocialModerate 4.422090e-04 4.862139e-02 1.0004423
## compromiso_biopsicosocialSevere 1.304123e-01 5.342074e-02 1.1392980
## tipo_programaEM 2.422097e-01 5.090462e-02 1.2740613
## estatus_ocupacional2 -1.558728e-01 3.177069e-02 0.8556680
## estatus_ocupacional3 -1.271755e-01 3.773423e-02 0.8805791
## freq_cons2 5.016766e-02 6.211012e-02 1.0514474
## freq_cons3 1.331815e-01 6.350953e-02 1.1424573
## freq_cons4 -5.766434e-02 1.080247e-01 0.9439667
## freq_cons5 -1.071270e-02 9.924167e-02 0.9893445
## freq_cons6 2.282011e-01 5.991186e-02 1.2563380
## edad_al_ing -1.997428e-02 1.591287e-03 0.9802239
## cluster(id) 1.027647e-07 5.314420e-07 1.0000001
## strata(event)event=2 1.155575e-01 3.646793e-02 1.1224991
## strata(event)event=3 1.355690e-01 5.847250e-02 1.1451882
## lower 0.95 upper 0.95 z
## terap_disTerapeutic discharge 0.5515677 0.6179021 -18.577263419
## sexF 0.8874876 1.0356159 -1.071225300
## edad_inicio 0.9895637 0.9998079 -2.033091273
## es_conyugalSeparated 0.9515557 1.1384913 0.874711574
## es_conyugalSingle 0.8620947 0.9713673 -2.914184701
## es_conyugalWidower 0.9265182 1.4410997 1.282680745
## susCocaine 1.1282996 1.3245781 4.910297612
## susMarijuana 0.8367213 1.0839391 -0.739437290
## susOther 0.6167594 0.9711255 -2.212955642
## susCocaine paste 1.4860990 1.7160382 12.754190705
## escolaridadSecundaria o menor 0.8453510 0.9630866 -3.090681454
## escolaridadPrimaria o menor 0.7792888 0.8968835 -4.995326567
## compromiso_biopsicosocialModerate 0.9095057 1.1004711 0.009094948
## compromiso_biopsicosocialSevere 1.0260429 1.2650543 2.441229682
## tipo_programaEM 1.1530821 1.4077334 4.758107813
## estatus_ocupacional2 0.8040111 0.9106439 -4.906181085
## estatus_ocupacional3 0.8178034 0.9481735 -3.370296727
## freq_cons2 0.9309349 1.1875606 0.807721123
## freq_cons3 1.0087431 1.2938961 2.097031619
## freq_cons4 0.7638461 1.1665611 -0.533806883
## freq_cons5 0.8144658 1.2017723 -0.107945606
## freq_cons6 1.1171447 1.4128744 3.808947082
## edad_al_ing 0.9771715 0.9832858 -12.552281759
## cluster(id) 0.9999991 1.0000011 0.193369616
## strata(event)event=2 1.0450677 1.2056675 3.168743826
## strata(event)event=3 1.0211863 1.2842476 2.318509048
## p
## terap_disTerapeutic discharge 0.000000e+00
## sexF 2.840681e-01
## edad_inicio 4.204330e-02
## es_conyugalSeparated 3.817309e-01
## es_conyugalSingle 3.566188e-03
## es_conyugalWidower 1.996039e-01
## susCocaine 9.093827e-07
## susMarijuana 4.596415e-01
## susOther 2.690070e-02
## susCocaine paste 0.000000e+00
## escolaridadSecundaria o menor 1.996977e-03
## escolaridadPrimaria o menor 5.873629e-07
## compromiso_biopsicosocialModerate 9.927434e-01
## compromiso_biopsicosocialSevere 1.463734e-02
## tipo_programaEM 1.954161e-06
## estatus_ocupacional2 9.286679e-07
## estatus_ocupacional3 7.508728e-04
## freq_cons2 4.192511e-01
## freq_cons3 3.599078e-02
## freq_cons4 5.934752e-01
## freq_cons5 9.140388e-01
## freq_cons6 1.395598e-04
## edad_al_ing 0.000000e+00
## cluster(id) 8.466695e-01
## strata(event)event=2 1.530993e-03
## strata(event)event=3 2.042167e-02
##
## Wald Chi-square = 1620.425 on 26 df p = 0 n = 107665
##
## Covariance-Matrix:
## terap_disTerapeutic discharge sexF
## terap_disTerapeutic discharge 8.393377e-04 -2.531194e-05
## sexF -2.531194e-05 1.550588e-03
## edad_inicio 1.837344e-06 -2.038832e-05
## es_conyugalSeparated 2.199380e-05 6.183484e-05
## es_conyugalSingle -1.171900e-04 1.087679e-04
## es_conyugalWidower 1.567135e-04 -1.143456e-04
## susCocaine 3.653730e-05 -4.649270e-05
## susMarijuana -4.202416e-05 9.488892e-05
## susOther -1.352222e-04 1.556134e-05
## susCocaine paste -4.375726e-05 2.859689e-05
## escolaridadSecundaria o menor -7.022718e-05 7.149566e-05
## escolaridadPrimaria o menor -1.468887e-05 -3.757147e-05
## compromiso_biopsicosocialModerate 1.724508e-05 -4.195927e-05
## compromiso_biopsicosocialSevere -5.306063e-05 5.842256e-05
## tipo_programaEM 1.149951e-05 -1.125375e-03
## estatus_ocupacional2 8.104718e-06 1.898950e-04
## estatus_ocupacional3 3.808934e-06 -3.883575e-04
## freq_cons2 -1.049432e-05 -8.564732e-05
## freq_cons3 1.776449e-04 5.900789e-05
## freq_cons4 2.088266e-04 1.781623e-04
## freq_cons5 -6.613175e-05 -1.283491e-04
## freq_cons6 1.063691e-04 1.149273e-04
## edad_al_ing -4.978528e-06 7.394926e-06
## cluster(id) 1.030270e-09 6.187998e-10
## strata(event)event=2 8.866400e-06 1.597498e-04
## strata(event)event=3 1.654408e-04 -1.807115e-04
## edad_inicio es_conyugalSeparated
## terap_disTerapeutic discharge 1.837344e-06 2.199380e-05
## sexF -2.038832e-05 6.183484e-05
## edad_inicio 6.902998e-06 -6.351427e-06
## es_conyugalSeparated -6.351427e-06 2.093630e-03
## es_conyugalSingle 5.583356e-06 4.798639e-04
## es_conyugalWidower -2.042030e-05 6.378992e-04
## susCocaine -9.049534e-06 7.483598e-05
## susMarijuana -1.594319e-05 1.901297e-05
## susOther -6.358150e-05 -1.530652e-04
## susCocaine paste -4.034162e-06 1.434415e-05
## escolaridadSecundaria o menor -1.659048e-06 5.295845e-05
## escolaridadPrimaria o menor -1.977144e-06 5.637744e-05
## compromiso_biopsicosocialModerate 5.930150e-07 -1.096789e-05
## compromiso_biopsicosocialSevere -2.986648e-06 -1.818910e-05
## tipo_programaEM -5.834955e-07 -2.079714e-04
## estatus_ocupacional2 6.868535e-06 7.083164e-05
## estatus_ocupacional3 9.102929e-06 4.411777e-05
## freq_cons2 1.480142e-05 -9.017892e-05
## freq_cons3 1.843818e-05 -1.468180e-04
## freq_cons4 -4.920682e-06 -7.222412e-05
## freq_cons5 1.548855e-05 -2.076110e-04
## freq_cons6 1.826475e-05 -1.303432e-04
## edad_al_ing -1.435501e-06 -9.775896e-06
## cluster(id) -3.736143e-11 -8.891059e-10
## strata(event)event=2 9.845946e-06 -1.422016e-04
## strata(event)event=3 3.790844e-06 -1.885097e-04
## es_conyugalSingle es_conyugalWidower
## terap_disTerapeutic discharge -1.171900e-04 1.567135e-04
## sexF 1.087679e-04 -1.143456e-04
## edad_inicio 5.583356e-06 -2.042030e-05
## es_conyugalSeparated 4.798639e-04 6.378992e-04
## es_conyugalSingle 9.268573e-04 4.119083e-04
## es_conyugalWidower 4.119083e-04 1.269854e-02
## susCocaine -1.063282e-05 -1.090063e-04
## susMarijuana 6.208825e-06 -1.725694e-04
## susOther -2.407164e-04 -3.730691e-04
## susCocaine paste -5.490225e-06 -2.014217e-04
## escolaridadSecundaria o menor 6.989475e-05 -3.106700e-05
## escolaridadPrimaria o menor 3.803236e-05 -1.582287e-04
## compromiso_biopsicosocialModerate 1.969678e-05 8.500236e-05
## compromiso_biopsicosocialSevere 4.160528e-05 1.063502e-04
## tipo_programaEM -2.215303e-04 -3.372913e-04
## estatus_ocupacional2 2.555536e-04 1.064601e-04
## estatus_ocupacional3 1.582516e-04 -4.494091e-05
## freq_cons2 -6.962697e-05 -4.096119e-05
## freq_cons3 -1.603051e-04 1.433304e-04
## freq_cons4 -1.858381e-04 2.661867e-04
## freq_cons5 -1.862885e-04 -1.011660e-04
## freq_cons6 -1.696500e-04 -7.922656e-05
## edad_al_ing 7.840206e-06 -1.923572e-05
## cluster(id) -1.715925e-09 -8.697117e-10
## strata(event)event=2 -6.697560e-05 1.553577e-04
## strata(event)event=3 -1.546974e-04 -1.821994e-04
## susCocaine susMarijuana susOther
## terap_disTerapeutic discharge 3.653730e-05 -4.202416e-05 -1.352222e-04
## sexF -4.649270e-05 9.488892e-05 1.556134e-05
## edad_inicio -9.049534e-06 -1.594319e-05 -6.358150e-05
## es_conyugalSeparated 7.483598e-05 1.901297e-05 -1.530652e-04
## es_conyugalSingle -1.063282e-05 6.208825e-06 -2.407164e-04
## es_conyugalWidower -1.090063e-04 -1.725694e-04 -3.730691e-04
## susCocaine 1.674004e-03 9.304555e-04 7.868737e-04
## susMarijuana 9.304555e-04 4.361076e-03 8.606333e-04
## susOther 7.868737e-04 8.606333e-04 1.341254e-02
## susCocaine paste 8.801843e-04 9.238679e-04 7.691440e-04
## escolaridadSecundaria o menor 5.773384e-05 9.629176e-05 3.793401e-05
## escolaridadPrimaria o menor 2.239458e-04 1.351883e-04 1.426758e-05
## compromiso_biopsicosocialModerate -1.598788e-04 2.458493e-05 1.048139e-04
## compromiso_biopsicosocialSevere -1.943034e-04 1.337645e-04 3.767338e-04
## tipo_programaEM -1.260819e-04 -1.808374e-04 -3.181483e-04
## estatus_ocupacional2 -7.890284e-05 -1.425996e-04 -9.836689e-05
## estatus_ocupacional3 1.377666e-04 -1.421198e-04 -8.674379e-05
## freq_cons2 -7.536614e-05 9.226451e-05 -8.015961e-05
## freq_cons3 -1.313272e-04 -9.213109e-05 -2.178813e-04
## freq_cons4 -1.637926e-04 -2.086384e-04 8.399256e-04
## freq_cons5 -2.332141e-04 -1.050430e-04 -2.283146e-04
## freq_cons6 -6.537237e-05 -6.954390e-05 -4.775846e-04
## edad_al_ing 1.886631e-05 3.003438e-05 1.386873e-05
## cluster(id) 1.130641e-09 1.343879e-10 4.709190e-10
## strata(event)event=2 -7.116839e-05 -2.618133e-05 -3.588837e-04
## strata(event)event=3 -4.048967e-05 2.760417e-05 -1.260419e-04
## susCocaine paste
## terap_disTerapeutic discharge -4.375726e-05
## sexF 2.859689e-05
## edad_inicio -4.034162e-06
## es_conyugalSeparated 1.434415e-05
## es_conyugalSingle -5.490225e-06
## es_conyugalWidower -2.014217e-04
## susCocaine 8.801843e-04
## susMarijuana 9.238679e-04
## susOther 7.691440e-04
## susCocaine paste 1.346934e-03
## escolaridadSecundaria o menor -3.911935e-05
## escolaridadPrimaria o menor -4.903545e-05
## compromiso_biopsicosocialModerate -1.477154e-04
## compromiso_biopsicosocialSevere -2.328224e-04
## tipo_programaEM -2.064192e-04
## estatus_ocupacional2 3.088843e-05
## estatus_ocupacional3 1.629340e-04
## freq_cons2 1.897276e-04
## freq_cons3 -8.883578e-06
## freq_cons4 -2.238510e-04
## freq_cons5 -1.226612e-04
## freq_cons6 9.620044e-06
## edad_al_ing 2.019057e-05
## cluster(id) -1.055784e-09
## strata(event)event=2 -1.459358e-04
## strata(event)event=3 -1.823126e-04
## escolaridadSecundaria o menor
## terap_disTerapeutic discharge -7.022718e-05
## sexF 7.149566e-05
## edad_inicio -1.659048e-06
## es_conyugalSeparated 5.295845e-05
## es_conyugalSingle 6.989475e-05
## es_conyugalWidower -3.106700e-05
## susCocaine 5.773384e-05
## susMarijuana 9.629176e-05
## susOther 3.793401e-05
## susCocaine paste -3.911935e-05
## escolaridadSecundaria o menor 1.106477e-03
## escolaridadPrimaria o menor 7.803730e-04
## compromiso_biopsicosocialModerate -9.808778e-05
## compromiso_biopsicosocialSevere 5.991944e-06
## tipo_programaEM -8.365620e-05
## estatus_ocupacional2 6.041784e-05
## estatus_ocupacional3 4.625335e-05
## freq_cons2 1.901913e-05
## freq_cons3 -8.550231e-05
## freq_cons4 6.438147e-05
## freq_cons5 -2.525381e-06
## freq_cons6 2.374465e-05
## edad_al_ing 4.752515e-06
## cluster(id) -1.066061e-09
## strata(event)event=2 -3.312738e-05
## strata(event)event=3 3.462381e-05
## escolaridadPrimaria o menor
## terap_disTerapeutic discharge -1.468887e-05
## sexF -3.757147e-05
## edad_inicio -1.977144e-06
## es_conyugalSeparated 5.637744e-05
## es_conyugalSingle 3.803236e-05
## es_conyugalWidower -1.582287e-04
## susCocaine 2.239458e-04
## susMarijuana 1.351883e-04
## susOther 1.426758e-05
## susCocaine paste -4.903545e-05
## escolaridadSecundaria o menor 7.803730e-04
## escolaridadPrimaria o menor 1.285495e-03
## compromiso_biopsicosocialModerate -4.565120e-05
## compromiso_biopsicosocialSevere -4.647628e-05
## tipo_programaEM 8.658725e-07
## estatus_ocupacional2 2.753758e-05
## estatus_ocupacional3 4.221846e-05
## freq_cons2 -1.018965e-04
## freq_cons3 -1.391149e-04
## freq_cons4 -1.152174e-04
## freq_cons5 -1.095223e-04
## freq_cons6 -8.544364e-05
## edad_al_ing 2.933880e-08
## cluster(id) 1.133147e-10
## strata(event)event=2 -5.099029e-05
## strata(event)event=3 1.525001e-05
## compromiso_biopsicosocialModerate
## terap_disTerapeutic discharge 1.724508e-05
## sexF -4.195927e-05
## edad_inicio 5.930150e-07
## es_conyugalSeparated -1.096789e-05
## es_conyugalSingle 1.969678e-05
## es_conyugalWidower 8.500236e-05
## susCocaine -1.598788e-04
## susMarijuana 2.458493e-05
## susOther 1.048139e-04
## susCocaine paste -1.477154e-04
## escolaridadSecundaria o menor -9.808778e-05
## escolaridadPrimaria o menor -4.565120e-05
## compromiso_biopsicosocialModerate 2.364039e-03
## compromiso_biopsicosocialSevere 2.174167e-03
## tipo_programaEM -1.700216e-05
## estatus_ocupacional2 3.503498e-05
## estatus_ocupacional3 3.688455e-05
## freq_cons2 1.140827e-05
## freq_cons3 -1.310576e-04
## freq_cons4 8.435691e-04
## freq_cons5 -1.565585e-04
## freq_cons6 -2.059431e-04
## edad_al_ing -2.904643e-06
## cluster(id) 1.297011e-09
## strata(event)event=2 3.540187e-05
## strata(event)event=3 -1.104049e-04
## compromiso_biopsicosocialSevere
## terap_disTerapeutic discharge -5.306063e-05
## sexF 5.842256e-05
## edad_inicio -2.986648e-06
## es_conyugalSeparated -1.818910e-05
## es_conyugalSingle 4.160528e-05
## es_conyugalWidower 1.063502e-04
## susCocaine -1.943034e-04
## susMarijuana 1.337645e-04
## susOther 3.767338e-04
## susCocaine paste -2.328224e-04
## escolaridadSecundaria o menor 5.991944e-06
## escolaridadPrimaria o menor -4.647628e-05
## compromiso_biopsicosocialModerate 2.174167e-03
## compromiso_biopsicosocialSevere 2.853776e-03
## tipo_programaEM -1.829790e-04
## estatus_ocupacional2 2.600138e-04
## estatus_ocupacional3 -3.233313e-05
## freq_cons2 -9.841966e-05
## freq_cons3 -3.939644e-04
## freq_cons4 6.454523e-04
## freq_cons5 -2.554438e-04
## freq_cons6 -4.691994e-04
## edad_al_ing -5.636330e-07
## cluster(id) -6.587505e-10
## strata(event)event=2 -5.123306e-05
## strata(event)event=3 -1.552545e-04
## tipo_programaEM estatus_ocupacional2
## terap_disTerapeutic discharge 1.149951e-05 8.104718e-06
## sexF -1.125375e-03 1.898950e-04
## edad_inicio -5.834955e-07 6.868535e-06
## es_conyugalSeparated -2.079714e-04 7.083164e-05
## es_conyugalSingle -2.215303e-04 2.555536e-04
## es_conyugalWidower -3.372913e-04 1.064601e-04
## susCocaine -1.260819e-04 -7.890284e-05
## susMarijuana -1.808374e-04 -1.425996e-04
## susOther -3.181483e-04 -9.836689e-05
## susCocaine paste -2.064192e-04 3.088843e-05
## escolaridadSecundaria o menor -8.365620e-05 6.041784e-05
## escolaridadPrimaria o menor 8.658725e-07 2.753758e-05
## compromiso_biopsicosocialModerate -1.700216e-05 3.503498e-05
## compromiso_biopsicosocialSevere -1.829790e-04 2.600138e-04
## tipo_programaEM 2.591280e-03 -1.396455e-04
## estatus_ocupacional2 -1.396455e-04 1.009377e-03
## estatus_ocupacional3 -4.264808e-05 3.678711e-04
## freq_cons2 -1.232086e-04 6.710594e-07
## freq_cons3 -1.361627e-04 1.335186e-04
## freq_cons4 -5.557535e-04 1.789175e-04
## freq_cons5 -6.719920e-05 6.031364e-05
## freq_cons6 -2.482443e-04 1.316289e-04
## edad_al_ing 5.585884e-06 -3.955719e-06
## cluster(id) 7.641933e-10 -1.839489e-09
## strata(event)event=2 -4.546542e-05 1.369994e-04
## strata(event)event=3 1.637233e-04 5.152898e-05
## estatus_ocupacional3 freq_cons2
## terap_disTerapeutic discharge 3.808934e-06 -1.049432e-05
## sexF -3.883575e-04 -8.564732e-05
## edad_inicio 9.102929e-06 1.480142e-05
## es_conyugalSeparated 4.411777e-05 -9.017892e-05
## es_conyugalSingle 1.582516e-04 -6.962697e-05
## es_conyugalWidower -4.494091e-05 -4.096119e-05
## susCocaine 1.377666e-04 -7.536614e-05
## susMarijuana -1.421198e-04 9.226451e-05
## susOther -8.674379e-05 -8.015961e-05
## susCocaine paste 1.629340e-04 1.897276e-04
## escolaridadSecundaria o menor 4.625335e-05 1.901913e-05
## escolaridadPrimaria o menor 4.221846e-05 -1.018965e-04
## compromiso_biopsicosocialModerate 3.688455e-05 1.140827e-05
## compromiso_biopsicosocialSevere -3.233313e-05 -9.841966e-05
## tipo_programaEM -4.264808e-05 -1.232086e-04
## estatus_ocupacional2 3.678711e-04 6.710594e-07
## estatus_ocupacional3 1.423872e-03 6.452662e-06
## freq_cons2 6.452662e-06 3.857668e-03
## freq_cons3 -6.720028e-05 3.108618e-03
## freq_cons4 -5.645148e-05 2.913890e-03
## freq_cons5 -6.619456e-05 3.077916e-03
## freq_cons6 -9.579014e-05 3.108722e-03
## edad_al_ing -3.883930e-06 -2.511084e-06
## cluster(id) -1.653261e-09 -2.454656e-09
## strata(event)event=2 -1.228958e-04 -5.124312e-05
## strata(event)event=3 2.068569e-04 -5.115549e-05
## freq_cons3 freq_cons4 freq_cons5
## terap_disTerapeutic discharge 1.776449e-04 2.088266e-04 -6.613175e-05
## sexF 5.900789e-05 1.781623e-04 -1.283491e-04
## edad_inicio 1.843818e-05 -4.920682e-06 1.548855e-05
## es_conyugalSeparated -1.468180e-04 -7.222412e-05 -2.076110e-04
## es_conyugalSingle -1.603051e-04 -1.858381e-04 -1.862885e-04
## es_conyugalWidower 1.433304e-04 2.661867e-04 -1.011660e-04
## susCocaine -1.313272e-04 -1.637926e-04 -2.332141e-04
## susMarijuana -9.213109e-05 -2.086384e-04 -1.050430e-04
## susOther -2.178813e-04 8.399256e-04 -2.283146e-04
## susCocaine paste -8.883578e-06 -2.238510e-04 -1.226612e-04
## escolaridadSecundaria o menor -8.550231e-05 6.438147e-05 -2.525381e-06
## escolaridadPrimaria o menor -1.391149e-04 -1.152174e-04 -1.095223e-04
## compromiso_biopsicosocialModerate -1.310576e-04 8.435691e-04 -1.565585e-04
## compromiso_biopsicosocialSevere -3.939644e-04 6.454523e-04 -2.554438e-04
## tipo_programaEM -1.361627e-04 -5.557535e-04 -6.719920e-05
## estatus_ocupacional2 1.335186e-04 1.789175e-04 6.031364e-05
## estatus_ocupacional3 -6.720028e-05 -5.645148e-05 -6.619456e-05
## freq_cons2 3.108618e-03 2.913890e-03 3.077916e-03
## freq_cons3 4.033460e-03 2.993865e-03 3.067985e-03
## freq_cons4 2.993865e-03 1.166934e-02 3.071766e-03
## freq_cons5 3.067985e-03 3.071766e-03 9.848909e-03
## freq_cons6 3.247161e-03 3.069990e-03 3.119826e-03
## edad_al_ing -6.503208e-06 -1.102184e-05 -4.986171e-07
## cluster(id) 1.001919e-09 2.266281e-09 -1.267046e-09
## strata(event)event=2 1.910876e-04 3.020939e-04 -1.717260e-04
## strata(event)event=3 8.526473e-05 9.388583e-05 3.116079e-04
## freq_cons6 edad_al_ing cluster(id)
## terap_disTerapeutic discharge 1.063691e-04 -4.978528e-06 1.030270e-09
## sexF 1.149273e-04 7.394926e-06 6.187998e-10
## edad_inicio 1.826475e-05 -1.435501e-06 -3.736143e-11
## es_conyugalSeparated -1.303432e-04 -9.775896e-06 -8.891059e-10
## es_conyugalSingle -1.696500e-04 7.840206e-06 -1.715925e-09
## es_conyugalWidower -7.922656e-05 -1.923572e-05 -8.697117e-10
## susCocaine -6.537237e-05 1.886631e-05 1.130641e-09
## susMarijuana -6.954390e-05 3.003438e-05 1.343879e-10
## susOther -4.775846e-04 1.386873e-05 4.709190e-10
## susCocaine paste 9.620044e-06 2.019057e-05 -1.055784e-09
## escolaridadSecundaria o menor 2.374465e-05 4.752515e-06 -1.066061e-09
## escolaridadPrimaria o menor -8.544364e-05 2.933880e-08 1.133147e-10
## compromiso_biopsicosocialModerate -2.059431e-04 -2.904643e-06 1.297011e-09
## compromiso_biopsicosocialSevere -4.691994e-04 -5.636330e-07 -6.587505e-10
## tipo_programaEM -2.482443e-04 5.585884e-06 7.641933e-10
## estatus_ocupacional2 1.316289e-04 -3.955719e-06 -1.839489e-09
## estatus_ocupacional3 -9.579014e-05 -3.883930e-06 -1.653261e-09
## freq_cons2 3.108722e-03 -2.511084e-06 -2.454656e-09
## freq_cons3 3.247161e-03 -6.503208e-06 1.001919e-09
## freq_cons4 3.069990e-03 -1.102184e-05 2.266281e-09
## freq_cons5 3.119826e-03 -4.986171e-07 -1.267046e-09
## freq_cons6 3.589431e-03 -4.747184e-06 4.874425e-10
## edad_al_ing -4.747184e-06 2.532194e-06 -1.534344e-11
## cluster(id) 4.874425e-10 -1.534344e-11 2.824305e-13
## strata(event)event=2 1.516310e-04 -6.028313e-06 2.929477e-09
## strata(event)event=3 1.044709e-04 8.517409e-07 -7.292657e-10
## strata(event)event=2 strata(event)event=3
## terap_disTerapeutic discharge 8.866400e-06 1.654408e-04
## sexF 1.597498e-04 -1.807115e-04
## edad_inicio 9.845946e-06 3.790844e-06
## es_conyugalSeparated -1.422016e-04 -1.885097e-04
## es_conyugalSingle -6.697560e-05 -1.546974e-04
## es_conyugalWidower 1.553577e-04 -1.821994e-04
## susCocaine -7.116839e-05 -4.048967e-05
## susMarijuana -2.618133e-05 2.760417e-05
## susOther -3.588837e-04 -1.260419e-04
## susCocaine paste -1.459358e-04 -1.823126e-04
## escolaridadSecundaria o menor -3.312738e-05 3.462381e-05
## escolaridadPrimaria o menor -5.099029e-05 1.525001e-05
## compromiso_biopsicosocialModerate 3.540187e-05 -1.104049e-04
## compromiso_biopsicosocialSevere -5.123306e-05 -1.552545e-04
## tipo_programaEM -4.546542e-05 1.637233e-04
## estatus_ocupacional2 1.369994e-04 5.152898e-05
## estatus_ocupacional3 -1.228958e-04 2.068569e-04
## freq_cons2 -5.124312e-05 -5.115549e-05
## freq_cons3 1.910876e-04 8.526473e-05
## freq_cons4 3.020939e-04 9.388583e-05
## freq_cons5 -1.717260e-04 3.116079e-04
## freq_cons6 1.516310e-04 1.044709e-04
## edad_al_ing -6.028313e-06 8.517409e-07
## cluster(id) 2.929477e-09 -7.292657e-10
## strata(event)event=2 1.329910e-03 2.697949e-04
## strata(event)event=3 2.697949e-04 3.419034e-03
##
## Generalized concordance probability:
## concordance prob. lower 0.95 upper 0.95
## terap_disTerapeutic discharge 0.3686 0.3555 0.3819
## sexF 0.4895 0.4702 0.5087
## edad_inicio 0.4987 0.4974 0.5000
## es_conyugalSeparated 0.5100 0.4876 0.5324
## es_conyugalSingle 0.4778 0.4630 0.4927
## es_conyugalWidower 0.5361 0.4809 0.5903
## susCocaine 0.5501 0.5301 0.5698
## susMarijuana 0.4878 0.4556 0.5201
## susOther 0.4363 0.3815 0.4927
## susCocaine paste 0.6149 0.5978 0.6318
## escolaridadSecundaria o menor 0.4743 0.4581 0.4906
## escolaridadPrimaria o menor 0.4553 0.4380 0.4728
## compromiso_biopsicosocialModerate 0.5001 0.4763 0.5239
## compromiso_biopsicosocialSevere 0.5326 0.5064 0.5585
## tipo_programaEM 0.5603 0.5355 0.5847
## estatus_ocupacional2 0.4611 0.4457 0.4766
## estatus_ocupacional3 0.4682 0.4499 0.4867
## freq_cons2 0.5125 0.4821 0.5429
## freq_cons3 0.5332 0.5022 0.5641
## freq_cons4 0.4856 0.4331 0.5384
## freq_cons5 0.4973 0.4489 0.5458
## freq_cons6 0.5568 0.5277 0.5856
## edad_al_ing 0.4950 0.4942 0.4958
## cluster(id) 0.5000 0.5000 0.5000
## strata(event)event=2 0.5289 0.5110 0.5466
## strata(event)event=3 0.5338 0.5052 0.5622conc_gt_3 <- cbind.data.frame(conc_prob=concord(pwp_gt_imp3)[,1],
lo_ci95=concord(pwp_gt_imp3)[,2],
up_ci95=concord(pwp_gt_imp3)[,3],
conc_p=summary(pwp_gt_imp3, print = FALSE)$prob)%>%
data.table::data.table(keep.rownames=T)
res_gt_2_orig <- cbind.data.frame(HR=round(exp(coef(pwp_gt_imp2_2)),2),
Lo_CI95=round(exp(confint(pwp_gt_imp2_2)[,1]),2),
Up_CI95=round(exp(confint(pwp_gt_imp2_2)[,2]),2))%>%
data.table::data.table(keep.rownames=T)
res_tt_2 <- cbind.data.frame(HR=round(exp(pwp_tt_imp2$coeff),2),
Lo_ci95=round(exp(confint(pwp_tt_imp2))[,1],2),
Up_ci95=round(exp(confint(pwp_tt_imp2))[,2],2),
p=round(summary(pwp_tt_imp2)$prob,4)) %>%
data.table::data.table(keep.rownames=T)## coxphw(formula = Surv(tstart, tstop, status == 1) ~ terap_dis +
## sex + edad_inicio + es_conyugal + sus + escolaridad + compromiso_biopsicosocial +
## tipo_programa + estatus_ocupacional + freq_cons + edad_al_ing +
## cluster(id) + strata(event), data = rfimp, template = "PH",
## robust = TRUE)
##
## Model fitted by unweighted estimation (PH template)
##
## coef se(coef) exp(coef)
## terap_disTerapeutic discharge -8.024978e-01 1.607211e-02 0.4482080
## sexF 1.092396e-02 1.905807e-02 1.0109838
## edad_inicio -4.286349e-03 1.469352e-03 0.9957228
## es_conyugalSeparated 1.314690e-02 2.389423e-02 1.0132337
## es_conyugalSingle -9.497325e-02 1.545851e-02 0.9093973
## es_conyugalWidower -3.217443e-02 7.162466e-02 0.9683377
## susCocaine 1.898527e-01 2.146106e-02 1.2090715
## susMarijuana -9.166240e-02 3.391420e-02 0.9124131
## susOther -9.667179e-02 5.468585e-02 0.9078539
## susCocaine paste 4.729839e-01 1.798983e-02 1.6047756
## escolaridadSecundaria o menor -2.872179e-02 1.779562e-02 0.9716868
## escolaridadPrimaria o menor -1.362333e-01 2.082738e-02 0.8726390
## compromiso_biopsicosocialModerate 1.989925e-02 2.818378e-02 1.0200986
## compromiso_biopsicosocialSevere 2.227805e-01 2.997854e-02 1.2495462
## tipo_programaEM 2.756856e-01 2.370806e-02 1.3174335
## estatus_ocupacional2 -1.398882e-01 1.572835e-02 0.8694554
## estatus_ocupacional3 -7.063956e-02 1.929443e-02 0.9317977
## freq_cons2 4.196661e-02 3.067360e-02 1.0428597
## freq_cons3 9.028878e-02 3.252568e-02 1.0944903
## freq_cons4 -6.396277e-02 4.610457e-02 0.9380399
## freq_cons5 -2.070734e-02 6.375919e-02 0.9795056
## freq_cons6 1.429484e-01 3.010223e-02 1.1536703
## edad_al_ing -2.245987e-02 8.263703e-04 0.9777905
## cluster(id) -3.163487e-07 2.669394e-07 0.9999997
## strata(event)event=2 -1.672330e+00 2.265202e-02 0.1878090
## strata(event)event=3 -1.484049e+00 3.577731e-02 0.2267179
## lower 0.95 upper 0.95 z
## terap_disTerapeutic discharge 0.4343092 0.4625517 -49.9310783
## sexF 0.9739170 1.0494614 0.5731936
## edad_inicio 0.9928594 0.9985945 -2.9171692
## es_conyugalSeparated 0.9668761 1.0618140 0.5502122
## es_conyugalSingle 0.8822575 0.9373719 -6.1437534
## es_conyugalWidower 0.8415110 1.1142787 -0.4492088
## susCocaine 1.1592691 1.2610133 8.8463773
## susMarijuana 0.8537362 0.9751229 -2.7027731
## susOther 0.8155814 1.0105659 -1.7677659
## susCocaine paste 1.5491781 1.6623685 26.2917400
## escolaridadSecundaria o menor 0.9383797 1.0061760 -1.6139811
## escolaridadPrimaria o menor 0.8377343 0.9089980 -6.5410684
## compromiso_biopsicosocialModerate 0.9652772 1.0780334 0.7060534
## compromiso_biopsicosocialSevere 1.1782422 1.3251655 7.4313328
## tipo_programaEM 1.2576169 1.3800952 11.6283470
## estatus_ocupacional2 0.8430616 0.8966755 -8.8940173
## estatus_ocupacional3 0.8972184 0.9677097 -3.6611383
## freq_cons2 0.9820112 1.1074784 1.3681669
## freq_cons3 1.0268949 1.1665351 2.7759233
## freq_cons4 0.8569925 1.0267521 -1.3873413
## freq_cons5 0.8644403 1.1098872 -0.3247743
## freq_cons6 1.0875736 1.2237840 4.7487651
## edad_al_ing 0.9762081 0.9793754 -27.1789426
## cluster(id) 0.9999992 1.0000002 -1.1850959
## strata(event)event=2 0.1796532 0.1963351 -73.8269338
## strata(event)event=3 0.2113645 0.2431865 -41.4801657
## p
## terap_disTerapeutic discharge 0.000000e+00
## sexF 5.665136e-01
## edad_inicio 3.532241e-03
## es_conyugalSeparated 5.821738e-01
## es_conyugalSingle 8.059395e-10
## es_conyugalWidower 6.532810e-01
## susCocaine 0.000000e+00
## susMarijuana 6.876367e-03
## susOther 7.710004e-02
## susCocaine paste 0.000000e+00
## escolaridadSecundaria o menor 1.065315e-01
## escolaridadPrimaria o menor 6.108092e-11
## compromiso_biopsicosocialModerate 4.801549e-01
## compromiso_biopsicosocialSevere 1.074696e-13
## tipo_programaEM 0.000000e+00
## estatus_ocupacional2 0.000000e+00
## estatus_ocupacional3 2.510972e-04
## freq_cons2 1.712598e-01
## freq_cons3 5.504520e-03
## freq_cons4 1.653377e-01
## freq_cons5 7.453519e-01
## freq_cons6 2.046625e-06
## edad_al_ing 0.000000e+00
## cluster(id) 2.359795e-01
## strata(event)event=2 0.000000e+00
## strata(event)event=3 0.000000e+00
##
## Wald Chi-square = 10214.58 on 26 df p = 0 n = 107665
##
## Covariance-Matrix:
## terap_disTerapeutic discharge sexF
## terap_disTerapeutic discharge 2.583127e-04 1.802511e-06
## sexF 1.802511e-06 3.632099e-04
## edad_inicio 1.255406e-07 -4.256289e-06
## es_conyugalSeparated 3.588721e-06 -7.452006e-06
## es_conyugalSingle 3.661299e-06 1.386564e-05
## es_conyugalWidower 2.215999e-05 -6.049736e-05
## susCocaine 9.044088e-06 4.995838e-06
## susMarijuana 5.162432e-06 8.859409e-06
## susOther -3.851224e-06 -5.214619e-05
## susCocaine paste 5.782823e-06 1.666083e-05
## escolaridadSecundaria o menor 1.005460e-05 -3.005648e-06
## escolaridadPrimaria o menor 2.056282e-05 -1.819006e-05
## compromiso_biopsicosocialModerate 1.209934e-05 -1.420788e-05
## compromiso_biopsicosocialSevere 1.059804e-05 -1.939204e-05
## tipo_programaEM -1.695442e-05 -2.617178e-04
## estatus_ocupacional2 1.340496e-06 1.523752e-05
## estatus_ocupacional3 9.672090e-07 -7.632170e-05
## freq_cons2 5.543169e-06 1.024557e-05
## freq_cons3 3.700809e-06 1.708952e-05
## freq_cons4 5.890527e-06 -2.420824e-06
## freq_cons5 1.163044e-05 -4.920416e-05
## freq_cons6 1.112672e-06 1.985522e-05
## edad_al_ing -6.161452e-07 1.469894e-06
## cluster(id) -5.588805e-12 -2.515936e-11
## strata(event)event=2 5.491410e-05 1.110850e-05
## strata(event)event=3 5.473478e-05 4.410919e-06
## edad_inicio es_conyugalSeparated
## terap_disTerapeutic discharge 1.255406e-07 3.588721e-06
## sexF -4.256289e-06 -7.452006e-06
## edad_inicio 2.158996e-06 -7.555630e-07
## es_conyugalSeparated -7.555630e-07 5.709343e-04
## es_conyugalSingle 8.095662e-09 1.232361e-04
## es_conyugalWidower -4.527475e-06 1.683697e-04
## susCocaine -1.046948e-06 9.327147e-06
## susMarijuana 1.053665e-07 5.182111e-06
## susOther -9.287360e-06 1.058232e-05
## susCocaine paste -6.211819e-07 7.592695e-06
## escolaridadSecundaria o menor 4.436777e-07 1.723062e-05
## escolaridadPrimaria o menor 1.759178e-06 3.114173e-05
## compromiso_biopsicosocialModerate 1.340130e-06 -6.053416e-06
## compromiso_biopsicosocialSevere 2.753892e-06 -2.073221e-05
## tipo_programaEM 6.212272e-07 1.450960e-06
## estatus_ocupacional2 3.996534e-07 1.857873e-05
## estatus_ocupacional3 7.790948e-08 1.356848e-05
## freq_cons2 2.564283e-07 -9.904212e-06
## freq_cons3 6.748147e-07 -1.464066e-05
## freq_cons4 5.733285e-08 -1.175891e-05
## freq_cons5 1.612417e-06 -1.734600e-05
## freq_cons6 6.933902e-07 -1.385407e-05
## edad_al_ing -3.513469e-07 -2.560931e-06
## cluster(id) -5.710164e-12 2.251793e-11
## strata(event)event=2 1.723147e-06 -3.375200e-06
## strata(event)event=3 1.899491e-06 6.536801e-06
## es_conyugalSingle es_conyugalWidower
## terap_disTerapeutic discharge 3.661299e-06 2.215999e-05
## sexF 1.386564e-05 -6.049736e-05
## edad_inicio 8.095662e-09 -4.527475e-06
## es_conyugalSeparated 1.232361e-04 1.683697e-04
## es_conyugalSingle 2.389654e-04 9.567003e-05
## es_conyugalWidower 9.567003e-05 5.130092e-03
## susCocaine 1.633936e-05 2.315068e-05
## susMarijuana -6.981691e-07 -6.683162e-06
## susOther 6.614377e-06 1.116159e-05
## susCocaine paste 4.653279e-06 1.590179e-05
## escolaridadSecundaria o menor 8.386112e-06 -8.680778e-06
## escolaridadPrimaria o menor 1.528820e-05 -3.332953e-05
## compromiso_biopsicosocialModerate -1.098637e-05 -8.817277e-06
## compromiso_biopsicosocialSevere -2.231261e-05 -2.728708e-05
## tipo_programaEM -5.758556e-06 1.687879e-05
## estatus_ocupacional2 3.096394e-05 8.148496e-06
## estatus_ocupacional3 1.397706e-05 -2.685623e-05
## freq_cons2 -6.106722e-06 -2.271995e-05
## freq_cons3 -7.980694e-06 -1.269733e-05
## freq_cons4 3.081344e-06 -1.965100e-06
## freq_cons5 -2.285541e-06 -1.722339e-06
## freq_cons6 -1.152475e-05 -1.938378e-05
## edad_al_ing 3.300478e-06 -5.545718e-06
## cluster(id) 8.499375e-12 1.371148e-10
## strata(event)event=2 -1.847130e-06 3.914212e-06
## strata(event)event=3 -2.225480e-06 4.743283e-06
## susCocaine susMarijuana susOther
## terap_disTerapeutic discharge 9.044088e-06 5.162432e-06 -3.851224e-06
## sexF 4.995838e-06 8.859409e-06 -5.214619e-05
## edad_inicio -1.046948e-06 1.053665e-07 -9.287360e-06
## es_conyugalSeparated 9.327147e-06 5.182111e-06 1.058232e-05
## es_conyugalSingle 1.633936e-05 -6.981691e-07 6.614377e-06
## es_conyugalWidower 2.315068e-05 -6.683162e-06 1.116159e-05
## susCocaine 4.605773e-04 2.254460e-04 1.883162e-04
## susMarijuana 2.254460e-04 1.150173e-03 2.049565e-04
## susOther 1.883162e-04 2.049565e-04 2.990543e-03
## susCocaine paste 2.166978e-04 2.326437e-04 1.949784e-04
## escolaridadSecundaria o menor 5.799822e-06 1.126939e-05 2.735345e-05
## escolaridadPrimaria o menor 3.386519e-05 2.986194e-05 3.379529e-05
## compromiso_biopsicosocialModerate -2.626686e-05 2.897770e-05 -1.266405e-05
## compromiso_biopsicosocialSevere -3.946154e-05 4.216643e-05 -9.359780e-06
## tipo_programaEM -9.736462e-06 -7.813965e-06 2.873195e-05
## estatus_ocupacional2 1.972955e-06 4.637056e-07 1.895116e-05
## estatus_ocupacional3 1.208821e-05 -1.873487e-05 -9.485198e-06
## freq_cons2 1.176751e-05 4.642436e-06 -4.543163e-06
## freq_cons3 1.095324e-05 -1.494101e-05 -2.162508e-05
## freq_cons4 -5.983923e-06 -6.583473e-06 -3.791382e-05
## freq_cons5 -1.874824e-05 -1.984053e-05 -1.982899e-05
## freq_cons6 7.054946e-06 -5.229201e-05 -8.268279e-05
## edad_al_ing 4.062359e-06 6.295317e-06 2.127572e-06
## cluster(id) 4.367220e-11 -1.074380e-11 -7.188836e-11
## strata(event)event=2 -1.343219e-05 1.746954e-05 1.957096e-05
## strata(event)event=3 -1.716912e-05 1.310420e-05 3.437216e-05
## susCocaine paste
## terap_disTerapeutic discharge 5.782823e-06
## sexF 1.666083e-05
## edad_inicio -6.211819e-07
## es_conyugalSeparated 7.592695e-06
## es_conyugalSingle 4.653279e-06
## es_conyugalWidower 1.590179e-05
## susCocaine 2.166978e-04
## susMarijuana 2.326437e-04
## susOther 1.949784e-04
## susCocaine paste 3.236340e-04
## escolaridadSecundaria o menor -1.595477e-05
## escolaridadPrimaria o menor -8.442995e-06
## compromiso_biopsicosocialModerate -3.373196e-05
## compromiso_biopsicosocialSevere -5.646749e-05
## tipo_programaEM -1.584262e-05
## estatus_ocupacional2 2.990092e-05
## estatus_ocupacional3 1.532432e-05
## freq_cons2 7.926595e-06
## freq_cons3 -7.432597e-06
## freq_cons4 -2.514642e-05
## freq_cons5 -2.490591e-05
## freq_cons6 -2.366350e-05
## edad_al_ing 4.267198e-06
## cluster(id) -2.753626e-11
## strata(event)event=2 -4.365727e-05
## strata(event)event=3 -6.079733e-05
## escolaridadSecundaria o menor
## terap_disTerapeutic discharge 1.005460e-05
## sexF -3.005648e-06
## edad_inicio 4.436777e-07
## es_conyugalSeparated 1.723062e-05
## es_conyugalSingle 8.386112e-06
## es_conyugalWidower -8.680778e-06
## susCocaine 5.799822e-06
## susMarijuana 1.126939e-05
## susOther 2.735345e-05
## susCocaine paste -1.595477e-05
## escolaridadSecundaria o menor 3.166840e-04
## escolaridadPrimaria o menor 2.444299e-04
## compromiso_biopsicosocialModerate -1.460601e-06
## compromiso_biopsicosocialSevere -7.885576e-06
## tipo_programaEM 3.128833e-06
## estatus_ocupacional2 1.134448e-06
## estatus_ocupacional3 -2.369690e-06
## freq_cons2 -1.452384e-06
## freq_cons3 3.813393e-06
## freq_cons4 -7.109855e-06
## freq_cons5 -8.303751e-06
## freq_cons6 -6.164328e-07
## edad_al_ing 9.083137e-08
## cluster(id) -3.420857e-11
## strata(event)event=2 -1.645705e-06
## strata(event)event=3 1.565631e-06
## escolaridadPrimaria o menor
## terap_disTerapeutic discharge 2.056282e-05
## sexF -1.819006e-05
## edad_inicio 1.759178e-06
## es_conyugalSeparated 3.114173e-05
## es_conyugalSingle 1.528820e-05
## es_conyugalWidower -3.332953e-05
## susCocaine 3.386519e-05
## susMarijuana 2.986194e-05
## susOther 3.379529e-05
## susCocaine paste -8.442995e-06
## escolaridadSecundaria o menor 2.444299e-04
## escolaridadPrimaria o menor 4.337799e-04
## compromiso_biopsicosocialModerate -4.029758e-06
## compromiso_biopsicosocialSevere -2.147576e-05
## tipo_programaEM 6.890418e-06
## estatus_ocupacional2 2.306196e-06
## estatus_ocupacional3 -1.644304e-05
## freq_cons2 3.775016e-06
## freq_cons3 7.790612e-06
## freq_cons4 -4.679486e-06
## freq_cons5 -8.223586e-06
## freq_cons6 2.412324e-06
## edad_al_ing -9.542708e-07
## cluster(id) -5.442875e-11
## strata(event)event=2 9.858369e-06
## strata(event)event=3 1.766931e-05
## compromiso_biopsicosocialModerate
## terap_disTerapeutic discharge 1.209934e-05
## sexF -1.420788e-05
## edad_inicio 1.340130e-06
## es_conyugalSeparated -6.053416e-06
## es_conyugalSingle -1.098637e-05
## es_conyugalWidower -8.817277e-06
## susCocaine -2.626686e-05
## susMarijuana 2.897770e-05
## susOther -1.266405e-05
## susCocaine paste -3.373196e-05
## escolaridadSecundaria o menor -1.460601e-06
## escolaridadPrimaria o menor -4.029758e-06
## compromiso_biopsicosocialModerate 7.943253e-04
## compromiso_biopsicosocialSevere 7.373078e-04
## tipo_programaEM -7.888853e-06
## estatus_ocupacional2 2.235012e-05
## estatus_ocupacional3 1.228023e-06
## freq_cons2 -5.472811e-05
## freq_cons3 -7.715335e-05
## freq_cons4 3.076384e-05
## freq_cons5 -1.476317e-06
## freq_cons6 -7.388886e-05
## edad_al_ing -2.787161e-07
## cluster(id) 2.967286e-11
## strata(event)event=2 -6.015747e-06
## strata(event)event=3 -1.140085e-05
## compromiso_biopsicosocialSevere
## terap_disTerapeutic discharge 1.059804e-05
## sexF -1.939204e-05
## edad_inicio 2.753892e-06
## es_conyugalSeparated -2.073221e-05
## es_conyugalSingle -2.231261e-05
## es_conyugalWidower -2.728708e-05
## susCocaine -3.946154e-05
## susMarijuana 4.216643e-05
## susOther -9.359780e-06
## susCocaine paste -5.646749e-05
## escolaridadSecundaria o menor -7.885576e-06
## escolaridadPrimaria o menor -2.147576e-05
## compromiso_biopsicosocialModerate 7.373078e-04
## compromiso_biopsicosocialSevere 8.987126e-04
## tipo_programaEM -4.413917e-05
## estatus_ocupacional2 5.460877e-05
## estatus_ocupacional3 1.261679e-05
## freq_cons2 -6.591552e-05
## freq_cons3 -1.093020e-04
## freq_cons4 2.978569e-05
## freq_cons5 -1.222373e-05
## freq_cons6 -1.331848e-04
## edad_al_ing -5.037690e-07
## cluster(id) 3.390675e-11
## strata(event)event=2 -1.436272e-05
## strata(event)event=3 -2.365048e-05
## tipo_programaEM estatus_ocupacional2
## terap_disTerapeutic discharge -1.695442e-05 1.340496e-06
## sexF -2.617178e-04 1.523752e-05
## edad_inicio 6.212272e-07 3.996534e-07
## es_conyugalSeparated 1.450960e-06 1.857873e-05
## es_conyugalSingle -5.758556e-06 3.096394e-05
## es_conyugalWidower 1.687879e-05 8.148496e-06
## susCocaine -9.736462e-06 1.972955e-06
## susMarijuana -7.813965e-06 4.637056e-07
## susOther 2.873195e-05 1.895116e-05
## susCocaine paste -1.584262e-05 2.990092e-05
## escolaridadSecundaria o menor 3.128833e-06 1.134448e-06
## escolaridadPrimaria o menor 6.890418e-06 2.306196e-06
## compromiso_biopsicosocialModerate -7.888853e-06 2.235012e-05
## compromiso_biopsicosocialSevere -4.413917e-05 5.460877e-05
## tipo_programaEM 5.620721e-04 -2.372208e-07
## estatus_ocupacional2 -2.372208e-07 2.473810e-04
## estatus_ocupacional3 -1.307560e-05 1.130349e-04
## freq_cons2 -2.024722e-05 4.467911e-06
## freq_cons3 -2.027295e-05 2.512704e-05
## freq_cons4 -6.641965e-06 -1.357763e-06
## freq_cons5 2.148253e-05 1.589477e-05
## freq_cons6 -2.596021e-05 3.772743e-05
## edad_al_ing 9.157915e-08 -6.351967e-07
## cluster(id) 2.295569e-11 -3.515088e-11
## strata(event)event=2 -1.669072e-05 1.422800e-05
## strata(event)event=3 -1.628840e-05 2.513147e-05
## estatus_ocupacional3 freq_cons2
## terap_disTerapeutic discharge 9.672090e-07 5.543169e-06
## sexF -7.632170e-05 1.024557e-05
## edad_inicio 7.790948e-08 2.564283e-07
## es_conyugalSeparated 1.356848e-05 -9.904212e-06
## es_conyugalSingle 1.397706e-05 -6.106722e-06
## es_conyugalWidower -2.685623e-05 -2.271995e-05
## susCocaine 1.208821e-05 1.176751e-05
## susMarijuana -1.873487e-05 4.642436e-06
## susOther -9.485198e-06 -4.543163e-06
## susCocaine paste 1.532432e-05 7.926595e-06
## escolaridadSecundaria o menor -2.369690e-06 -1.452384e-06
## escolaridadPrimaria o menor -1.644304e-05 3.775016e-06
## compromiso_biopsicosocialModerate 1.228023e-06 -5.472811e-05
## compromiso_biopsicosocialSevere 1.261679e-05 -6.591552e-05
## tipo_programaEM -1.307560e-05 -2.024722e-05
## estatus_ocupacional2 1.130349e-04 4.467911e-06
## estatus_ocupacional3 3.722748e-04 6.553122e-06
## freq_cons2 6.553122e-06 9.408699e-04
## freq_cons3 1.278278e-05 7.745902e-04
## freq_cons4 6.089140e-06 7.613635e-04
## freq_cons5 1.056177e-05 7.646178e-04
## freq_cons6 1.417524e-05 7.772981e-04
## edad_al_ing -3.299026e-07 1.999652e-07
## cluster(id) -1.000888e-11 1.251537e-11
## strata(event)event=2 7.200321e-06 9.703402e-06
## strata(event)event=3 2.908196e-06 9.008329e-06
## freq_cons3 freq_cons4 freq_cons5
## terap_disTerapeutic discharge 3.700809e-06 5.890527e-06 1.163044e-05
## sexF 1.708952e-05 -2.420824e-06 -4.920416e-05
## edad_inicio 6.748147e-07 5.733285e-08 1.612417e-06
## es_conyugalSeparated -1.464066e-05 -1.175891e-05 -1.734600e-05
## es_conyugalSingle -7.980694e-06 3.081344e-06 -2.285541e-06
## es_conyugalWidower -1.269733e-05 -1.965100e-06 -1.722339e-06
## susCocaine 1.095324e-05 -5.983923e-06 -1.874824e-05
## susMarijuana -1.494101e-05 -6.583473e-06 -1.984053e-05
## susOther -2.162508e-05 -3.791382e-05 -1.982899e-05
## susCocaine paste -7.432597e-06 -2.514642e-05 -2.490591e-05
## escolaridadSecundaria o menor 3.813393e-06 -7.109855e-06 -8.303751e-06
## escolaridadPrimaria o menor 7.790612e-06 -4.679486e-06 -8.223586e-06
## compromiso_biopsicosocialModerate -7.715335e-05 3.076384e-05 -1.476317e-06
## compromiso_biopsicosocialSevere -1.093020e-04 2.978569e-05 -1.222373e-05
## tipo_programaEM -2.027295e-05 -6.641965e-06 2.148253e-05
## estatus_ocupacional2 2.512704e-05 -1.357763e-06 1.589477e-05
## estatus_ocupacional3 1.278278e-05 6.089140e-06 1.056177e-05
## freq_cons2 7.745902e-04 7.613635e-04 7.646178e-04
## freq_cons3 1.057920e-03 7.620007e-04 7.702028e-04
## freq_cons4 7.620007e-04 2.125631e-03 7.649385e-04
## freq_cons5 7.702028e-04 7.649385e-04 4.065234e-03
## freq_cons6 7.981437e-04 7.638247e-04 7.765623e-04
## edad_al_ing -1.518740e-07 1.445466e-07 -7.220400e-07
## cluster(id) 8.401378e-12 5.475653e-11 -2.482713e-11
## strata(event)event=2 3.848195e-06 1.468234e-05 -6.080855e-06
## strata(event)event=3 1.990009e-06 7.394918e-06 1.356532e-05
## freq_cons6 edad_al_ing cluster(id)
## terap_disTerapeutic discharge 1.112672e-06 -6.161452e-07 -5.588805e-12
## sexF 1.985522e-05 1.469894e-06 -2.515936e-11
## edad_inicio 6.933902e-07 -3.513469e-07 -5.710164e-12
## es_conyugalSeparated -1.385407e-05 -2.560931e-06 2.251793e-11
## es_conyugalSingle -1.152475e-05 3.300478e-06 8.499375e-12
## es_conyugalWidower -1.938378e-05 -5.545718e-06 1.371148e-10
## susCocaine 7.054946e-06 4.062359e-06 4.367220e-11
## susMarijuana -5.229201e-05 6.295317e-06 -1.074380e-11
## susOther -8.268279e-05 2.127572e-06 -7.188836e-11
## susCocaine paste -2.366350e-05 4.267198e-06 -2.753626e-11
## escolaridadSecundaria o menor -6.164328e-07 9.083137e-08 -3.420857e-11
## escolaridadPrimaria o menor 2.412324e-06 -9.542708e-07 -5.442875e-11
## compromiso_biopsicosocialModerate -7.388886e-05 -2.787161e-07 2.967286e-11
## compromiso_biopsicosocialSevere -1.331848e-04 -5.037690e-07 3.390675e-11
## tipo_programaEM -2.596021e-05 9.157915e-08 2.295569e-11
## estatus_ocupacional2 3.772743e-05 -6.351967e-07 -3.515088e-11
## estatus_ocupacional3 1.417524e-05 -3.299026e-07 -1.000888e-11
## freq_cons2 7.772981e-04 1.999652e-07 1.251537e-11
## freq_cons3 7.981437e-04 -1.518740e-07 8.401378e-12
## freq_cons4 7.638247e-04 1.445466e-07 5.475653e-11
## freq_cons5 7.765623e-04 -7.220400e-07 -2.482713e-11
## freq_cons6 9.061443e-04 -8.305322e-07 1.225831e-11
## edad_al_ing -8.305322e-07 6.828879e-07 -8.372481e-13
## cluster(id) 1.225831e-11 -8.372481e-13 7.125662e-14
## strata(event)event=2 -8.068725e-06 -3.934549e-07 -2.230078e-11
## strata(event)event=3 -1.038157e-05 -2.798872e-07 5.180528e-11
## strata(event)event=2 strata(event)event=3
## terap_disTerapeutic discharge 5.491410e-05 5.473478e-05
## sexF 1.110850e-05 4.410919e-06
## edad_inicio 1.723147e-06 1.899491e-06
## es_conyugalSeparated -3.375200e-06 6.536801e-06
## es_conyugalSingle -1.847130e-06 -2.225480e-06
## es_conyugalWidower 3.914212e-06 4.743283e-06
## susCocaine -1.343219e-05 -1.716912e-05
## susMarijuana 1.746954e-05 1.310420e-05
## susOther 1.957096e-05 3.437216e-05
## susCocaine paste -4.365727e-05 -6.079733e-05
## escolaridadSecundaria o menor -1.645705e-06 1.565631e-06
## escolaridadPrimaria o menor 9.858369e-06 1.766931e-05
## compromiso_biopsicosocialModerate -6.015747e-06 -1.140085e-05
## compromiso_biopsicosocialSevere -1.436272e-05 -2.365048e-05
## tipo_programaEM -1.669072e-05 -1.628840e-05
## estatus_ocupacional2 1.422800e-05 2.513147e-05
## estatus_ocupacional3 7.200321e-06 2.908196e-06
## freq_cons2 9.703402e-06 9.008329e-06
## freq_cons3 3.848195e-06 1.990009e-06
## freq_cons4 1.468234e-05 7.394918e-06
## freq_cons5 -6.080855e-06 1.356532e-05
## freq_cons6 -8.068725e-06 -1.038157e-05
## edad_al_ing -3.934549e-07 -2.798872e-07
## cluster(id) -2.230078e-11 5.180528e-11
## strata(event)event=2 5.131142e-04 3.967838e-04
## strata(event)event=3 3.967838e-04 1.280016e-03
##
## Generalized concordance probability: Estimates may be biased!
## concordance prob. lower 0.95 upper 0.95
## terap_disTerapeutic discharge 0.3095 0.3028 0.3163
## sexF 0.5027 0.4934 0.5121
## edad_inicio 0.4989 0.4982 0.4996
## es_conyugalSeparated 0.5033 0.4916 0.5150
## es_conyugalSingle 0.4763 0.4687 0.4838
## es_conyugalWidower 0.4920 0.4570 0.5270
## susCocaine 0.5473 0.5369 0.5577
## susMarijuana 0.4771 0.4605 0.4937
## susOther 0.4759 0.4492 0.5026
## susCocaine paste 0.6161 0.6077 0.6244
## escolaridadSecundaria o menor 0.4928 0.4841 0.5015
## escolaridadPrimaria o menor 0.4660 0.4559 0.4762
## compromiso_biopsicosocialModerate 0.5050 0.4912 0.5188
## compromiso_biopsicosocialSevere 0.5555 0.5409 0.5699
## tipo_programaEM 0.5685 0.5571 0.5798
## estatus_ocupacional2 0.4651 0.4574 0.4728
## estatus_ocupacional3 0.4823 0.4729 0.4918
## freq_cons2 0.5105 0.4955 0.5255
## freq_cons3 0.5226 0.5066 0.5384
## freq_cons4 0.4840 0.4615 0.5066
## freq_cons5 0.4948 0.4636 0.5260
## freq_cons6 0.5357 0.5210 0.5503
## edad_al_ing 0.4944 0.4940 0.4948
## cluster(id) 0.5000 0.5000 0.5000
## strata(event)event=2 0.1581 0.1523 0.1641
## strata(event)event=3 0.1848 0.1745 0.1956res_tt_3 <- cbind.data.frame(Avg_HR=round(exp(pwp_tt_imp3$coeff),2),
Lo_ci95=round(exp(confint(pwp_tt_imp3))[,1],2),
Up_ci95=round(exp(confint(pwp_tt_imp3))[,2],2),
p=round(summary(pwp_tt_imp3)$prob,4))%>%
data.table::data.table(keep.rownames=T)## coxphw(formula = Surv(tstart, tstop, status == 1) ~ terap_dis +
## sex + edad_inicio + es_conyugal + sus + escolaridad + compromiso_biopsicosocial +
## tipo_programa + estatus_ocupacional + freq_cons + edad_al_ing +
## cluster(id) + strata(event), data = rfimp, template = "AHR",
## robust = T)
##
## Model fitted by weighted estimation (AHR template)
##
## coef se(coef) exp(coef)
## terap_disTerapeutic discharge -5.295226e-01 2.566850e-02 0.5888861
## sexF 1.448479e-02 2.816138e-02 1.0145902
## edad_inicio -1.627130e-03 2.014508e-03 0.9983742
## es_conyugalSeparated 1.624677e-02 3.865821e-02 1.0163795
## es_conyugalSingle -9.057335e-02 3.200596e-02 0.9134073
## es_conyugalWidower -1.291167e-01 1.057320e-01 0.8788714
## susCocaine 2.116217e-01 5.709780e-02 1.2356804
## susMarijuana -9.950953e-02 5.104528e-02 0.9052813
## susOther 7.018622e-03 7.703513e-02 1.0070433
## susCocaine paste 4.095137e-01 3.532545e-02 1.5060853
## escolaridadSecundaria o menor -5.442937e-02 2.852690e-02 0.9470254
## escolaridadPrimaria o menor -1.457280e-01 3.318956e-02 0.8643928
## compromiso_biopsicosocialModerate 5.354541e-02 4.127599e-02 1.0550049
## compromiso_biopsicosocialSevere 2.635818e-01 4.187826e-02 1.3015838
## tipo_programaEM 2.805434e-01 3.943641e-02 1.3238489
## estatus_ocupacional2 -7.725817e-02 2.927685e-02 0.9256508
## estatus_ocupacional3 -2.009002e-02 3.555002e-02 0.9801104
## freq_cons2 2.385253e-02 7.335942e-02 1.0241393
## freq_cons3 6.645398e-02 7.111215e-02 1.0687118
## freq_cons4 -4.130523e-02 7.711500e-02 0.9595362
## freq_cons5 4.980727e-02 1.020693e-01 1.0510685
## freq_cons6 8.333113e-02 6.570042e-02 1.0869017
## edad_al_ing -2.391285e-02 1.414653e-03 0.9763708
## cluster(id) -9.761864e-08 4.852795e-07 0.9999999
## strata(event)event=2 -1.573192e+00 2.559254e-02 0.2073821
## strata(event)event=3 -1.389766e+00 5.715777e-02 0.2491336
## lower 0.95 upper 0.95 z
## terap_disTerapeutic discharge 0.5599925 0.6192704 -20.62927578
## sexF 0.9601070 1.0721651 0.51434958
## edad_inicio 0.9944400 1.0023239 -0.80770589
## es_conyugalSeparated 0.9422149 1.0963818 0.42026707
## es_conyugalSingle 0.8578690 0.9725412 -2.82988963
## es_conyugalWidower 0.7143747 1.0812462 -1.22116948
## susCocaine 1.1048528 1.3819995 3.70630265
## susMarijuana 0.8190940 1.0005375 -1.94943640
## susOther 0.8659159 1.1711717 0.09110937
## susCocaine paste 1.4053370 1.6140561 11.59259945
## escolaridadSecundaria o menor 0.8955286 1.0014834 -1.90800187
## escolaridadPrimaria o menor 0.8099536 0.9224910 -4.39077804
## compromiso_biopsicosocialModerate 0.9730167 1.1439016 1.29725298
## compromiso_biopsicosocialSevere 1.1990169 1.4129246 6.29400219
## tipo_programaEM 1.2253780 1.4302329 7.11381547
## estatus_ocupacional2 0.8740307 0.9803196 -2.63888305
## estatus_ocupacional3 0.9141444 1.0508367 -0.56511977
## freq_cons2 0.8869832 1.1825041 0.32514612
## freq_cons3 0.9296722 1.2285458 0.93449543
## freq_cons4 0.8249373 1.1160966 -0.53563166
## freq_cons5 0.8604973 1.2838448 0.48797523
## freq_cons6 0.9555776 1.2362735 1.26834994
## edad_al_ing 0.9736674 0.9790817 -16.90368050
## cluster(id) 0.9999990 1.0000009 -0.20115962
## strata(event)event=2 0.1972363 0.2180498 -61.47073437
## strata(event)event=3 0.2227304 0.2786667 -24.31455626
## p
## terap_disTerapeutic discharge 0.000000e+00
## sexF 6.070076e-01
## edad_inicio 4.192599e-01
## es_conyugalSeparated 6.742904e-01
## es_conyugalSingle 4.656406e-03
## es_conyugalWidower 2.220219e-01
## susCocaine 2.103070e-04
## susMarijuana 5.124333e-02
## susOther 9.274057e-01
## susCocaine paste 0.000000e+00
## escolaridadSecundaria o menor 5.639097e-02
## escolaridadPrimaria o menor 1.129458e-05
## compromiso_biopsicosocialModerate 1.945442e-01
## compromiso_biopsicosocialSevere 3.093834e-10
## tipo_programaEM 1.128764e-12
## estatus_ocupacional2 8.317967e-03
## estatus_ocupacional3 5.719923e-01
## freq_cons2 7.450705e-01
## freq_cons3 3.500484e-01
## freq_cons4 5.922131e-01
## freq_cons5 6.255674e-01
## freq_cons6 2.046730e-01
## edad_al_ing 0.000000e+00
## cluster(id) 8.405738e-01
## strata(event)event=2 0.000000e+00
## strata(event)event=3 0.000000e+00
##
## Wald Chi-square = 5411.667 on 26 df p = 0 n = 107665
##
## Covariance-Matrix:
## terap_disTerapeutic discharge sexF
## terap_disTerapeutic discharge 6.588719e-04 -6.959531e-05
## sexF -6.959531e-05 7.930632e-04
## edad_inicio -1.191876e-06 -8.159208e-06
## es_conyugalSeparated 1.648846e-05 1.906048e-04
## es_conyugalSingle 8.258535e-05 3.100925e-05
## es_conyugalWidower 5.031901e-05 -2.912545e-05
## susCocaine 5.564477e-05 -1.516522e-04
## susMarijuana 5.578498e-05 -6.671573e-05
## susOther 4.402804e-05 -1.056074e-04
## susCocaine paste 1.361596e-04 -7.755924e-05
## escolaridadSecundaria o menor -2.245884e-04 5.507128e-05
## escolaridadPrimaria o menor -1.640004e-04 8.276961e-05
## compromiso_biopsicosocialModerate 1.658383e-04 -7.143025e-05
## compromiso_biopsicosocialSevere 8.267955e-05 -4.241225e-05
## tipo_programaEM -5.278180e-05 -5.736851e-04
## estatus_ocupacional2 -1.273639e-04 8.898391e-05
## estatus_ocupacional3 -8.739750e-05 -2.603011e-04
## freq_cons2 -7.317042e-04 2.092387e-04
## freq_cons3 -7.658055e-04 2.056382e-04
## freq_cons4 -7.097988e-04 2.138932e-04
## freq_cons5 -7.607715e-04 8.828651e-05
## freq_cons6 -7.701636e-04 3.091223e-04
## edad_al_ing 2.199010e-06 6.133628e-07
## cluster(id) 1.366928e-09 -7.789104e-11
## strata(event)event=2 1.102728e-04 4.569995e-05
## strata(event)event=3 2.757674e-04 -1.738867e-04
## edad_inicio es_conyugalSeparated
## terap_disTerapeutic discharge -1.191876e-06 1.648846e-05
## sexF -8.159208e-06 1.906048e-04
## edad_inicio 4.058242e-06 6.972689e-06
## es_conyugalSeparated 6.972689e-06 1.494458e-03
## es_conyugalSingle 3.679870e-06 4.170511e-04
## es_conyugalWidower 8.098042e-06 6.060965e-04
## susCocaine -2.528518e-05 -2.643385e-04
## susMarijuana -4.619454e-06 -1.120101e-04
## susOther -3.103980e-05 -2.184980e-04
## susCocaine paste -1.984045e-05 -2.964214e-04
## escolaridadSecundaria o menor 5.181062e-07 3.209577e-06
## escolaridadPrimaria o menor 2.989556e-06 2.092575e-04
## compromiso_biopsicosocialModerate -3.457541e-06 -2.079550e-05
## compromiso_biopsicosocialSevere -1.128395e-07 -3.124844e-05
## tipo_programaEM 4.393598e-06 -3.210886e-04
## estatus_ocupacional2 -4.012276e-06 2.613612e-05
## estatus_ocupacional3 -5.822206e-06 -2.876203e-04
## freq_cons2 -1.180780e-05 -1.498618e-04
## freq_cons3 -1.083260e-05 -3.559187e-04
## freq_cons4 -9.646219e-07 -4.694771e-05
## freq_cons5 6.246657e-06 -1.609439e-04
## freq_cons6 3.581213e-06 5.039766e-05
## edad_al_ing -1.103787e-06 -1.023584e-05
## cluster(id) 9.778008e-12 2.235486e-10
## strata(event)event=2 1.651075e-06 7.262425e-05
## strata(event)event=3 1.311754e-05 -1.638455e-04
## es_conyugalSingle es_conyugalWidower
## terap_disTerapeutic discharge 8.258535e-05 5.031901e-05
## sexF 3.100925e-05 -2.912545e-05
## edad_inicio 3.679870e-06 8.098042e-06
## es_conyugalSeparated 4.170511e-04 6.060965e-04
## es_conyugalSingle 1.024382e-03 3.717237e-04
## es_conyugalWidower 3.717237e-04 1.117926e-02
## susCocaine 7.032490e-04 -7.091975e-04
## susMarijuana -1.022866e-04 1.265338e-04
## susOther 9.415715e-05 -1.285821e-04
## susCocaine paste 3.504214e-05 -3.974634e-04
## escolaridadSecundaria o menor 1.550686e-06 -1.477535e-04
## escolaridadPrimaria o menor 1.941508e-04 -1.358043e-04
## compromiso_biopsicosocialModerate 2.616931e-04 -1.733680e-04
## compromiso_biopsicosocialSevere 1.190378e-05 -3.055689e-04
## tipo_programaEM -2.332489e-04 -4.224874e-04
## estatus_ocupacional2 2.172061e-04 -4.037149e-04
## estatus_ocupacional3 -2.375503e-04 -6.505909e-04
## freq_cons2 2.457865e-04 -7.187848e-04
## freq_cons3 -5.889950e-04 -7.935378e-04
## freq_cons4 -6.282456e-05 -2.667699e-04
## freq_cons5 -2.063030e-04 -4.383886e-04
## freq_cons6 -6.212270e-05 -2.134332e-04
## edad_al_ing 1.616208e-05 -2.220163e-05
## cluster(id) -4.851807e-09 -2.238961e-09
## strata(event)event=2 1.709761e-04 3.960624e-06
## strata(event)event=3 -4.665594e-04 1.010146e-04
## susCocaine susMarijuana susOther
## terap_disTerapeutic discharge 5.564477e-05 5.578498e-05 4.402804e-05
## sexF -1.516522e-04 -6.671573e-05 -1.056074e-04
## edad_inicio -2.528518e-05 -4.619454e-06 -3.103980e-05
## es_conyugalSeparated -2.643385e-04 -1.120101e-04 -2.184980e-04
## es_conyugalSingle 7.032490e-04 -1.022866e-04 9.415715e-05
## es_conyugalWidower -7.091975e-04 1.265338e-04 -1.285821e-04
## susCocaine 3.260158e-03 4.427580e-04 9.205182e-04
## susMarijuana 4.427580e-04 2.605621e-03 5.634878e-04
## susOther 9.205182e-04 5.634878e-04 5.934411e-03
## susCocaine paste 1.281508e-03 6.243331e-04 7.358264e-04
## escolaridadSecundaria o menor 1.627645e-04 -1.305635e-04 3.574978e-05
## escolaridadPrimaria o menor 4.964523e-04 -8.355587e-05 5.263616e-05
## compromiso_biopsicosocialModerate 6.103096e-04 -2.828513e-04 1.350438e-04
## compromiso_biopsicosocialSevere 2.510603e-04 -3.700340e-04 -5.374477e-05
## tipo_programaEM -2.479490e-04 -1.488559e-04 -1.292555e-04
## estatus_ocupacional2 6.673116e-04 -1.473646e-04 4.423126e-05
## estatus_ocupacional3 1.635635e-04 -1.010410e-04 -4.567368e-05
## freq_cons2 1.685501e-03 -1.842238e-04 2.038604e-04
## freq_cons3 3.509825e-04 -3.735050e-06 -2.395674e-05
## freq_cons4 5.082456e-04 -2.160998e-04 -1.175079e-04
## freq_cons5 5.510261e-04 -2.045260e-04 -4.844998e-05
## freq_cons6 3.659104e-04 -3.009960e-04 -2.534969e-04
## edad_al_ing 4.857683e-05 1.223392e-05 1.494248e-05
## cluster(id) -9.927618e-09 -2.274708e-09 -2.993462e-09
## strata(event)event=2 2.782426e-04 4.013672e-05 1.011703e-04
## strata(event)event=3 -1.228559e-03 -6.923467e-06 -2.038906e-04
## susCocaine paste
## terap_disTerapeutic discharge 1.361596e-04
## sexF -7.755924e-05
## edad_inicio -1.984045e-05
## es_conyugalSeparated -2.964214e-04
## es_conyugalSingle 3.504214e-05
## es_conyugalWidower -3.974634e-04
## susCocaine 1.281508e-03
## susMarijuana 6.243331e-04
## susOther 7.358264e-04
## susCocaine paste 1.247887e-03
## escolaridadSecundaria o menor -1.294702e-04
## escolaridadPrimaria o menor -9.228795e-05
## compromiso_biopsicosocialModerate 1.997051e-04
## compromiso_biopsicosocialSevere 1.120415e-05
## tipo_programaEM -4.503045e-05
## estatus_ocupacional2 2.135475e-04
## estatus_ocupacional3 1.123208e-04
## freq_cons2 1.766014e-04
## freq_cons3 -1.116545e-04
## freq_cons4 -2.853030e-04
## freq_cons5 -2.221094e-04
## freq_cons6 -4.322307e-04
## edad_al_ing 2.709271e-05
## cluster(id) -2.431295e-09
## strata(event)event=2 -1.411140e-05
## strata(event)event=3 -4.490192e-04
## escolaridadSecundaria o menor
## terap_disTerapeutic discharge -2.245884e-04
## sexF 5.507128e-05
## edad_inicio 5.181062e-07
## es_conyugalSeparated 3.209577e-06
## es_conyugalSingle 1.550686e-06
## es_conyugalWidower -1.477535e-04
## susCocaine 1.627645e-04
## susMarijuana -1.305635e-04
## susOther 3.574978e-05
## susCocaine paste -1.294702e-04
## escolaridadSecundaria o menor 8.137839e-04
## escolaridadPrimaria o menor 6.395736e-04
## compromiso_biopsicosocialModerate -1.950231e-05
## compromiso_biopsicosocialSevere 4.289091e-05
## tipo_programaEM 4.930918e-05
## estatus_ocupacional2 1.896956e-04
## estatus_ocupacional3 1.184853e-04
## freq_cons2 9.646801e-04
## freq_cons3 8.520004e-04
## freq_cons4 8.488966e-04
## freq_cons5 9.238946e-04
## freq_cons6 8.753230e-04
## edad_al_ing 1.251088e-07
## cluster(id) -2.185579e-09
## strata(event)event=2 1.104976e-05
## strata(event)event=3 -2.932721e-04
## escolaridadPrimaria o menor
## terap_disTerapeutic discharge -1.640004e-04
## sexF 8.276961e-05
## edad_inicio 2.989556e-06
## es_conyugalSeparated 2.092575e-04
## es_conyugalSingle 1.941508e-04
## es_conyugalWidower -1.358043e-04
## susCocaine 4.964523e-04
## susMarijuana -8.355587e-05
## susOther 5.263616e-05
## susCocaine paste -9.228795e-05
## escolaridadSecundaria o menor 6.395736e-04
## escolaridadPrimaria o menor 1.101547e-03
## compromiso_biopsicosocialModerate 4.596996e-05
## compromiso_biopsicosocialSevere 7.671744e-05
## tipo_programaEM -1.327855e-04
## estatus_ocupacional2 2.634624e-04
## estatus_ocupacional3 -4.931673e-05
## freq_cons2 9.376296e-04
## freq_cons3 6.329463e-04
## freq_cons4 7.468352e-04
## freq_cons5 8.115509e-04
## freq_cons6 8.089229e-04
## edad_al_ing -5.750359e-08
## cluster(id) -2.310226e-09
## strata(event)event=2 8.868287e-05
## strata(event)event=3 -4.132403e-04
## compromiso_biopsicosocialModerate
## terap_disTerapeutic discharge 1.658383e-04
## sexF -7.143025e-05
## edad_inicio -3.457541e-06
## es_conyugalSeparated -2.079550e-05
## es_conyugalSingle 2.616931e-04
## es_conyugalWidower -1.733680e-04
## susCocaine 6.103096e-04
## susMarijuana -2.828513e-04
## susOther 1.350438e-04
## susCocaine paste 1.997051e-04
## escolaridadSecundaria o menor -1.950231e-05
## escolaridadPrimaria o menor 4.596996e-05
## compromiso_biopsicosocialModerate 1.703708e-03
## compromiso_biopsicosocialSevere 1.467304e-03
## tipo_programaEM -7.486304e-05
## estatus_ocupacional2 2.462504e-04
## estatus_ocupacional3 2.128764e-05
## freq_cons2 -6.348695e-05
## freq_cons3 -5.961441e-04
## freq_cons4 -1.561599e-04
## freq_cons5 -3.570345e-04
## freq_cons6 -4.644802e-04
## edad_al_ing 1.225089e-05
## cluster(id) -1.690716e-09
## strata(event)event=2 9.857103e-05
## strata(event)event=3 -2.914151e-04
## compromiso_biopsicosocialSevere
## terap_disTerapeutic discharge 8.267955e-05
## sexF -4.241225e-05
## edad_inicio -1.128395e-07
## es_conyugalSeparated -3.124844e-05
## es_conyugalSingle 1.190378e-05
## es_conyugalWidower -3.055689e-04
## susCocaine 2.510603e-04
## susMarijuana -3.700340e-04
## susOther -5.374477e-05
## susCocaine paste 1.120415e-05
## escolaridadSecundaria o menor 4.289091e-05
## escolaridadPrimaria o menor 7.671744e-05
## compromiso_biopsicosocialModerate 1.467304e-03
## compromiso_biopsicosocialSevere 1.753788e-03
## tipo_programaEM 1.924381e-05
## estatus_ocupacional2 2.730328e-04
## estatus_ocupacional3 1.465416e-04
## freq_cons2 -7.240527e-05
## freq_cons3 -3.024677e-04
## freq_cons4 1.115552e-06
## freq_cons5 -1.878007e-04
## freq_cons6 -3.392646e-04
## edad_al_ing 4.628001e-06
## cluster(id) 1.650034e-09
## strata(event)event=2 1.107856e-05
## strata(event)event=3 -1.365745e-04
## tipo_programaEM estatus_ocupacional2
## terap_disTerapeutic discharge -5.278180e-05 -1.273639e-04
## sexF -5.736851e-04 8.898391e-05
## edad_inicio 4.393598e-06 -4.012276e-06
## es_conyugalSeparated -3.210886e-04 2.613612e-05
## es_conyugalSingle -2.332489e-04 2.172061e-04
## es_conyugalWidower -4.224874e-04 -4.037149e-04
## susCocaine -2.479490e-04 6.673116e-04
## susMarijuana -1.488559e-04 -1.473646e-04
## susOther -1.292555e-04 4.423126e-05
## susCocaine paste -4.503045e-05 2.135475e-04
## escolaridadSecundaria o menor 4.930918e-05 1.896956e-04
## escolaridadPrimaria o menor -1.327855e-04 2.634624e-04
## compromiso_biopsicosocialModerate -7.486304e-05 2.462504e-04
## compromiso_biopsicosocialSevere 1.924381e-05 2.730328e-04
## tipo_programaEM 1.555231e-03 6.795807e-06
## estatus_ocupacional2 6.795807e-06 8.571337e-04
## estatus_ocupacional3 2.948497e-04 4.297056e-04
## freq_cons2 -1.135365e-04 9.196188e-04
## freq_cons3 2.457275e-04 6.105122e-04
## freq_cons4 -4.683810e-05 5.563425e-04
## freq_cons5 9.113167e-05 6.123489e-04
## freq_cons6 -1.042459e-04 5.816214e-04
## edad_al_ing -2.133069e-06 1.052285e-05
## cluster(id) 3.704599e-09 -2.488625e-09
## strata(event)event=2 -1.752442e-04 1.319016e-04
## strata(event)event=3 4.870614e-04 -4.723509e-04
## estatus_ocupacional3 freq_cons2
## terap_disTerapeutic discharge -8.739750e-05 -7.317042e-04
## sexF -2.603011e-04 2.092387e-04
## edad_inicio -5.822206e-06 -1.180780e-05
## es_conyugalSeparated -2.876203e-04 -1.498618e-04
## es_conyugalSingle -2.375503e-04 2.457865e-04
## es_conyugalWidower -6.505909e-04 -7.187848e-04
## susCocaine 1.635635e-04 1.685501e-03
## susMarijuana -1.010410e-04 -1.842238e-04
## susOther -4.567368e-05 2.038604e-04
## susCocaine paste 1.123208e-04 1.766014e-04
## escolaridadSecundaria o menor 1.184853e-04 9.646801e-04
## escolaridadPrimaria o menor -4.931673e-05 9.376296e-04
## compromiso_biopsicosocialModerate 2.128764e-05 -6.348695e-05
## compromiso_biopsicosocialSevere 1.465416e-04 -7.240527e-05
## tipo_programaEM 2.948497e-04 -1.135365e-04
## estatus_ocupacional2 4.297056e-04 9.196188e-04
## estatus_ocupacional3 1.263804e-03 4.003840e-04
## freq_cons2 4.003840e-04 5.381604e-03
## freq_cons3 7.559230e-04 4.181406e-03
## freq_cons4 2.865163e-04 4.145828e-03
## freq_cons5 4.046166e-04 4.532855e-03
## freq_cons6 2.242655e-04 4.211848e-03
## edad_al_ing 3.449612e-06 2.087575e-05
## cluster(id) 2.316071e-09 -1.347063e-08
## strata(event)event=2 -1.604192e-05 2.215472e-04
## strata(event)event=3 1.226001e-04 -1.533919e-03
## freq_cons3 freq_cons4 freq_cons5
## terap_disTerapeutic discharge -7.658055e-04 -7.097988e-04 -7.607715e-04
## sexF 2.056382e-04 2.138932e-04 8.828651e-05
## edad_inicio -1.083260e-05 -9.646219e-07 6.246657e-06
## es_conyugalSeparated -3.559187e-04 -4.694771e-05 -1.609439e-04
## es_conyugalSingle -5.889950e-04 -6.282456e-05 -2.063030e-04
## es_conyugalWidower -7.935378e-04 -2.667699e-04 -4.383886e-04
## susCocaine 3.509825e-04 5.082456e-04 5.510261e-04
## susMarijuana -3.735050e-06 -2.160998e-04 -2.045260e-04
## susOther -2.395674e-05 -1.175079e-04 -4.844998e-05
## susCocaine paste -1.116545e-04 -2.853030e-04 -2.221094e-04
## escolaridadSecundaria o menor 8.520004e-04 8.488966e-04 9.238946e-04
## escolaridadPrimaria o menor 6.329463e-04 7.468352e-04 8.115509e-04
## compromiso_biopsicosocialModerate -5.961441e-04 -1.561599e-04 -3.570345e-04
## compromiso_biopsicosocialSevere -3.024677e-04 1.115552e-06 -1.878007e-04
## tipo_programaEM 2.457275e-04 -4.683810e-05 9.113167e-05
## estatus_ocupacional2 6.105122e-04 5.563425e-04 6.123489e-04
## estatus_ocupacional3 7.559230e-04 2.865163e-04 4.046166e-04
## freq_cons2 4.181406e-03 4.145828e-03 4.532855e-03
## freq_cons3 5.056937e-03 3.829044e-03 4.268998e-03
## freq_cons4 3.829044e-03 5.946723e-03 4.074560e-03
## freq_cons5 4.268998e-03 4.074560e-03 1.041813e-02
## freq_cons6 3.976241e-03 3.904866e-03 4.202631e-03
## edad_al_ing -1.774903e-06 -7.600662e-07 -3.164513e-06
## cluster(id) -3.883274e-09 -8.887917e-09 -9.232162e-09
## strata(event)event=2 -4.872591e-05 6.842503e-05 1.740479e-05
## strata(event)event=3 -5.367970e-04 -8.873988e-04 -9.072303e-04
## freq_cons6 edad_al_ing cluster(id)
## terap_disTerapeutic discharge -7.701636e-04 2.199010e-06 1.366928e-09
## sexF 3.091223e-04 6.133628e-07 -7.789104e-11
## edad_inicio 3.581213e-06 -1.103787e-06 9.778008e-12
## es_conyugalSeparated 5.039766e-05 -1.023584e-05 2.235486e-10
## es_conyugalSingle -6.212270e-05 1.616208e-05 -4.851807e-09
## es_conyugalWidower -2.134332e-04 -2.220163e-05 -2.238961e-09
## susCocaine 3.659104e-04 4.857683e-05 -9.927618e-09
## susMarijuana -3.009960e-04 1.223392e-05 -2.274708e-09
## susOther -2.534969e-04 1.494248e-05 -2.993462e-09
## susCocaine paste -4.322307e-04 2.709271e-05 -2.431295e-09
## escolaridadSecundaria o menor 8.753230e-04 1.251088e-07 -2.185579e-09
## escolaridadPrimaria o menor 8.089229e-04 -5.750359e-08 -2.310226e-09
## compromiso_biopsicosocialModerate -4.644802e-04 1.225089e-05 -1.690716e-09
## compromiso_biopsicosocialSevere -3.392646e-04 4.628001e-06 1.650034e-09
## tipo_programaEM -1.042459e-04 -2.133069e-06 3.704599e-09
## estatus_ocupacional2 5.816214e-04 1.052285e-05 -2.488625e-09
## estatus_ocupacional3 2.242655e-04 3.449612e-06 2.316071e-09
## freq_cons2 4.211848e-03 2.087575e-05 -1.347063e-08
## freq_cons3 3.976241e-03 -1.774903e-06 -3.883274e-09
## freq_cons4 3.904866e-03 -7.600662e-07 -8.887917e-09
## freq_cons5 4.202631e-03 -3.164513e-06 -9.232162e-09
## freq_cons6 4.316546e-03 -5.071064e-06 -7.853741e-09
## edad_al_ing -5.071064e-06 2.001244e-06 -1.482934e-10
## cluster(id) -7.853741e-09 -1.482934e-10 2.354962e-13
## strata(event)event=2 3.157412e-05 4.848960e-06 -1.894267e-09
## strata(event)event=3 -9.506299e-04 -2.189455e-05 7.610550e-09
## strata(event)event=2 strata(event)event=3
## terap_disTerapeutic discharge 1.102728e-04 2.757674e-04
## sexF 4.569995e-05 -1.738867e-04
## edad_inicio 1.651075e-06 1.311754e-05
## es_conyugalSeparated 7.262425e-05 -1.638455e-04
## es_conyugalSingle 1.709761e-04 -4.665594e-04
## es_conyugalWidower 3.960624e-06 1.010146e-04
## susCocaine 2.782426e-04 -1.228559e-03
## susMarijuana 4.013672e-05 -6.923467e-06
## susOther 1.011703e-04 -2.038906e-04
## susCocaine paste -1.411140e-05 -4.490192e-04
## escolaridadSecundaria o menor 1.104976e-05 -2.932721e-04
## escolaridadPrimaria o menor 8.868287e-05 -4.132403e-04
## compromiso_biopsicosocialModerate 9.857103e-05 -2.914151e-04
## compromiso_biopsicosocialSevere 1.107856e-05 -1.365745e-04
## tipo_programaEM -1.752442e-04 4.870614e-04
## estatus_ocupacional2 1.319016e-04 -4.723509e-04
## estatus_ocupacional3 -1.604192e-05 1.226001e-04
## freq_cons2 2.215472e-04 -1.533919e-03
## freq_cons3 -4.872591e-05 -5.367970e-04
## freq_cons4 6.842503e-05 -8.873988e-04
## freq_cons5 1.740479e-05 -9.072303e-04
## freq_cons6 3.157412e-05 -9.506299e-04
## edad_al_ing 4.848960e-06 -2.189455e-05
## cluster(id) -1.894267e-09 7.610550e-09
## strata(event)event=2 6.549780e-04 1.003843e-04
## strata(event)event=3 1.003843e-04 3.267011e-03
##
## Generalized concordance probability:
## concordance prob. lower 0.95 upper 0.95
## terap_disTerapeutic discharge 0.3706 0.3590 0.3824
## sexF 0.5036 0.4898 0.5174
## edad_inicio 0.4996 0.4986 0.5006
## es_conyugalSeparated 0.5041 0.4851 0.5230
## es_conyugalSingle 0.4774 0.4617 0.4930
## es_conyugalWidower 0.4678 0.4167 0.5195
## susCocaine 0.5527 0.5249 0.5802
## susMarijuana 0.4751 0.4503 0.5001
## susOther 0.5018 0.4641 0.5394
## susCocaine paste 0.6010 0.5843 0.6175
## escolaridadSecundaria o menor 0.4864 0.4724 0.5004
## escolaridadPrimaria o menor 0.4636 0.4475 0.4798
## compromiso_biopsicosocialModerate 0.5134 0.4932 0.5336
## compromiso_biopsicosocialSevere 0.5655 0.5453 0.5856
## tipo_programaEM 0.5697 0.5506 0.5885
## estatus_ocupacional2 0.4807 0.4664 0.4950
## estatus_ocupacional3 0.4950 0.4776 0.5124
## freq_cons2 0.5060 0.4701 0.5418
## freq_cons3 0.5166 0.4818 0.5513
## freq_cons4 0.4897 0.4520 0.5274
## freq_cons5 0.5124 0.4625 0.5621
## freq_cons6 0.5208 0.4886 0.5528
## edad_al_ing 0.4940 0.4933 0.4947
## cluster(id) 0.5000 0.5000 0.5000
## strata(event)event=2 0.1718 0.1647 0.1790
## strata(event)event=3 0.1994 0.1822 0.2179conc_tt_3 <- cbind.data.frame(conc_prob=concord(pwp_tt_imp3)[,1],
lo_ci95=concord(pwp_tt_imp3)[,2],
up_ci95=concord(pwp_tt_imp3)[,3],
conc_p=summary(pwp_tt_imp3, print = FALSE)$prob)%>%
data.table::data.table(keep.rownames=T)
res_tt_2_orig <- cbind.data.frame(HR=round(exp(coef(pwp_tt_imp2_2)),2),
Lo_CI95=round(exp(confint(pwp_tt_imp2_2)[,1]),2),
Up_CI95=round(exp(confint(pwp_tt_imp2_2)[,2]),2))%>%
data.table::data.table(keep.rownames=T)options(knitr.kable.NA = '')
res_gt_2 %>%
dplyr::left_join(res_gt_2_orig, by="rn") %>%
dplyr::left_join(res_gt_3, by="rn") %>%
dplyr::left_join(conc_gt_3, by="rn") %>%
#dplyr::bind_cols(res_gt_2_orig,res_gt_2,res_gt_3,conc_gt_3) %>%
knitr::kable("html") %>%
kableExtra::kable_classic(bootstrap_options = c("striped", "hover"),font_size = 12) %>%
kableExtra::add_header_above( c(" ", "PWP HR Var. Robusta" = 4, "PWP Original" = 3, "PWP Weighted"= 4, "Concordance"=4)) %>%
kableExtra::scroll_box(width = "100%", height = "375px") |
PWP HR Var. Robusta
|
PWP Original
|
PWP Weighted
|
Concordance
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rn | HR.x | Lo_ci95.x | Up_ci95.x | p.x | HR.y | Lo_CI95 | Up_CI95 | Avg_HR | Lo_ci95.y | Up_ci95.y | p.y | conc_prob | lo_ci95 | up_ci95 | conc_p |
| terap_disTerapeutic discharge | 0.39 | 0.38 | 0.41 | 0.0000 | 0.39 | 0.38 | 0.41 | 0.58 | 0.55 | 0.62 | 0.0000 | 0.3686 | 0.3555 | 0.3819 | 0.0000000 |
| sexF | 0.96 | 0.92 | 1.00 | 0.0382 | 0.96 | 0.93 | 1.00 | 0.96 | 0.89 | 1.04 | 0.2841 | 0.4895 | 0.4702 | 0.5087 | 0.2840681 |
| edad_inicio | 0.99 | 0.99 | 1.00 | 0.0000 | 0.99 | 0.99 | 1.00 | 0.99 | 0.99 | 1.00 | 0.0420 | 0.4987 | 0.4974 | 0.5000 | 0.0420433 |
| es_conyugalSeparated | 1.03 | 0.98 | 1.07 | 0.3018 | 1.02 | 0.98 | 1.07 | 1.04 | 0.95 | 1.14 | 0.3817 | 0.5100 | 0.4876 | 0.5324 | 0.3817309 |
| es_conyugalSingle | 0.92 | 0.90 | 0.95 | 0.0000 | 0.92 | 0.90 | 0.95 | 0.92 | 0.86 | 0.97 | 0.0036 | 0.4778 | 0.4630 | 0.4927 | 0.0035662 |
| es_conyugalWidower | 0.94 | 0.82 | 1.08 | 0.3734 | 0.94 | 0.82 | 1.08 | 1.16 | 0.93 | 1.44 | 0.1996 | 0.5361 | 0.4809 | 0.5903 | 0.1996039 |
| susCocaine | 1.23 | 1.18 | 1.28 | 0.0000 | 1.23 | 1.18 | 1.29 | 1.22 | 1.13 | 1.32 | 0.0000 | 0.5501 | 0.5301 | 0.5698 | 0.0000009 |
| susMarijuana | 0.92 | 0.86 | 0.99 | 0.0194 | 0.92 | 0.86 | 0.99 | 0.95 | 0.84 | 1.08 | 0.4596 | 0.4878 | 0.4556 | 0.5201 | 0.4596415 |
| susOther | 0.89 | 0.79 | 0.99 | 0.0325 | 0.89 | 0.79 | 0.99 | 0.77 | 0.62 | 0.97 | 0.0269 | 0.4363 | 0.3815 | 0.4927 | 0.0269007 |
| susCocaine paste | 1.66 | 1.60 | 1.72 | 0.0000 | 1.66 | 1.60 | 1.72 | 1.60 | 1.49 | 1.72 | 0.0000 | 0.6149 | 0.5978 | 0.6318 | 0.0000000 |
| escolaridadSecundaria o menor | 0.97 | 0.94 | 1.01 | 0.1052 | 0.97 | 0.94 | 1.01 | 0.90 | 0.85 | 0.96 | 0.0020 | 0.4743 | 0.4581 | 0.4906 | 0.0019970 |
| escolaridadPrimaria o menor | 0.88 | 0.84 | 0.91 | 0.0000 | 0.88 | 0.84 | 0.91 | 0.84 | 0.78 | 0.90 | 0.0000 | 0.4553 | 0.4380 | 0.4728 | 0.0000006 |
| compromiso_biopsicosocialModerate | 1.03 | 0.97 | 1.08 | 0.3586 | 1.03 | 0.97 | 1.08 | 1.00 | 0.91 | 1.10 | 0.9927 | 0.5001 | 0.4763 | 0.5239 | 0.9927434 |
| compromiso_biopsicosocialSevere | 1.23 | 1.16 | 1.31 | 0.0000 | 1.23 | 1.16 | 1.31 | 1.14 | 1.03 | 1.27 | 0.0146 | 0.5326 | 0.5064 | 0.5585 | 0.0146373 |
| tipo_programaEM | 1.34 | 1.27 | 1.40 | 0.0000 | 1.34 | 1.27 | 1.40 | 1.27 | 1.15 | 1.41 | 0.0000 | 0.5603 | 0.5355 | 0.5847 | 0.0000020 |
| estatus_ocupacional2 | 0.86 | 0.83 | 0.88 | 0.0000 | 0.86 | 0.83 | 0.88 | 0.86 | 0.80 | 0.91 | 0.0000 | 0.4611 | 0.4457 | 0.4766 | 0.0000009 |
| estatus_ocupacional3 | 0.93 | 0.89 | 0.97 | 0.0002 | 0.93 | 0.89 | 0.96 | 0.88 | 0.82 | 0.95 | 0.0008 | 0.4682 | 0.4499 | 0.4867 | 0.0007509 |
| freq_cons2 | 1.06 | 1.00 | 1.13 | 0.0539 | 1.06 | 1.00 | 1.13 | 1.05 | 0.93 | 1.19 | 0.4193 | 0.5125 | 0.4821 | 0.5429 | 0.4192511 |
| freq_cons3 | 1.12 | 1.05 | 1.19 | 0.0009 | 1.11 | 1.04 | 1.19 | 1.14 | 1.01 | 1.29 | 0.0360 | 0.5332 | 0.5022 | 0.5641 | 0.0359908 |
| freq_cons4 | 0.92 | 0.84 | 1.01 | 0.0833 | 0.92 | 0.84 | 1.01 | 0.94 | 0.76 | 1.17 | 0.5935 | 0.4856 | 0.4331 | 0.5384 | 0.5934752 |
| freq_cons5 | 0.89 | 0.78 | 1.00 | 0.0543 | 0.89 | 0.78 | 1.00 | 0.99 | 0.81 | 1.20 | 0.9140 | 0.4973 | 0.4489 | 0.5458 | 0.9140388 |
| freq_cons6 | 1.23 | 1.16 | 1.30 | 0.0000 | 1.22 | 1.15 | 1.30 | 1.26 | 1.12 | 1.41 | 0.0001 | 0.5568 | 0.5277 | 0.5856 | 0.0001396 |
| edad_al_ing | 0.98 | 0.98 | 0.98 | 0.0000 | 0.98 | 0.98 | 0.98 | 0.98 | 0.98 | 0.98 | 0.0000 | 0.4950 | 0.4942 | 0.4958 | 0.0000000 |
| cluster(id) | 1.00 | 1.00 | 1.00 | 0.3334 | 1.00 | 1.00 | 1.00 | 0.8467 | 0.5000 | 0.5000 | 0.5000 | 0.8466695 | |||
| strata(event)event=2 | 1.24 | 1.20 | 1.28 | 0.0000 | 1.12 | 1.05 | 1.21 | 0.0015 | 0.5289 | 0.5110 | 0.5466 | 0.0015310 | |||
| strata(event)event=3 | 1.30 | 1.23 | 1.38 | 0.0000 | 1.15 | 1.02 | 1.28 | 0.0204 | 0.5338 | 0.5052 | 0.5622 | 0.0204217 | |||
options(knitr.kable.NA = '')
res_tt_2 %>%
dplyr::left_join(res_tt_2_orig, by="rn") %>%
dplyr::left_join(res_tt_3, by="rn") %>%
dplyr::left_join(conc_tt_3, by="rn") %>%
#dplyr::bind_cols(res_gt_2_orig,res_gt_2,res_gt_3,conc_gt_3) %>%
knitr::kable("html") %>%
kableExtra::kable_classic(bootstrap_options = c("striped", "hover"),font_size = 12) %>%
kableExtra::add_header_above( c(" ", "PWP HR Var. Robusta" = 4, "PWP Original" = 3, "PWP Weighted"= 4, "Concordance"=4)) %>%
kableExtra::scroll_box(width = "100%", height = "375px") |
PWP HR Var. Robusta
|
PWP Original
|
PWP Weighted
|
Concordance
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rn | HR.x | Lo_ci95.x | Up_ci95.x | p.x | HR.y | Lo_CI95 | Up_CI95 | Avg_HR | Lo_ci95.y | Up_ci95.y | p.y | conc_prob | lo_ci95 | up_ci95 | conc_p |
| terap_disTerapeutic discharge | 0.45 | 0.43 | 0.46 | 0.0000 | 0.45 | 0.44 | 0.46 | 0.59 | 0.56 | 0.62 | 0.0000 | 0.3706 | 0.3590 | 0.3824 | 0.0000000 |
| sexF | 1.01 | 0.97 | 1.05 | 0.5665 | 1.01 | 0.97 | 1.05 | 1.01 | 0.96 | 1.07 | 0.6070 | 0.5036 | 0.4898 | 0.5174 | 0.6070076 |
| edad_inicio | 1.00 | 0.99 | 1.00 | 0.0035 | 1.00 | 0.99 | 1.00 | 1.00 | 0.99 | 1.00 | 0.4193 | 0.4996 | 0.4986 | 0.5006 | 0.4192599 |
| es_conyugalSeparated | 1.01 | 0.97 | 1.06 | 0.5822 | 1.01 | 0.97 | 1.06 | 1.02 | 0.94 | 1.10 | 0.6743 | 0.5041 | 0.4851 | 0.5230 | 0.6742904 |
| es_conyugalSingle | 0.91 | 0.88 | 0.94 | 0.0000 | 0.91 | 0.88 | 0.94 | 0.91 | 0.86 | 0.97 | 0.0047 | 0.4774 | 0.4617 | 0.4930 | 0.0046564 |
| es_conyugalWidower | 0.97 | 0.84 | 1.11 | 0.6533 | 0.97 | 0.84 | 1.12 | 0.88 | 0.71 | 1.08 | 0.2220 | 0.4678 | 0.4167 | 0.5195 | 0.2220219 |
| susCocaine | 1.21 | 1.16 | 1.26 | 0.0000 | 1.21 | 1.16 | 1.26 | 1.24 | 1.10 | 1.38 | 0.0002 | 0.5527 | 0.5249 | 0.5802 | 0.0002103 |
| susMarijuana | 0.91 | 0.85 | 0.98 | 0.0069 | 0.91 | 0.85 | 0.97 | 0.91 | 0.82 | 1.00 | 0.0512 | 0.4751 | 0.4503 | 0.5001 | 0.0512433 |
| susOther | 0.91 | 0.82 | 1.01 | 0.0771 | 0.90 | 0.80 | 1.01 | 1.01 | 0.87 | 1.17 | 0.9274 | 0.5018 | 0.4641 | 0.5394 | 0.9274057 |
| susCocaine paste | 1.60 | 1.55 | 1.66 | 0.0000 | 1.60 | 1.55 | 1.66 | 1.51 | 1.41 | 1.61 | 0.0000 | 0.6010 | 0.5843 | 0.6175 | 0.0000000 |
| escolaridadSecundaria o menor | 0.97 | 0.94 | 1.01 | 0.1065 | 0.97 | 0.94 | 1.01 | 0.95 | 0.90 | 1.00 | 0.0564 | 0.4864 | 0.4724 | 0.5004 | 0.0563910 |
| escolaridadPrimaria o menor | 0.87 | 0.84 | 0.91 | 0.0000 | 0.87 | 0.84 | 0.91 | 0.86 | 0.81 | 0.92 | 0.0000 | 0.4636 | 0.4475 | 0.4798 | 0.0000113 |
| compromiso_biopsicosocialModerate | 1.02 | 0.97 | 1.08 | 0.4802 | 1.02 | 0.96 | 1.07 | 1.06 | 0.97 | 1.14 | 0.1945 | 0.5134 | 0.4932 | 0.5336 | 0.1945442 |
| compromiso_biopsicosocialSevere | 1.25 | 1.18 | 1.33 | 0.0000 | 1.24 | 1.17 | 1.32 | 1.30 | 1.20 | 1.41 | 0.0000 | 0.5655 | 0.5453 | 0.5856 | 0.0000000 |
| tipo_programaEM | 1.32 | 1.26 | 1.38 | 0.0000 | 1.32 | 1.26 | 1.38 | 1.32 | 1.23 | 1.43 | 0.0000 | 0.5697 | 0.5506 | 0.5885 | 0.0000000 |
| estatus_ocupacional2 | 0.87 | 0.84 | 0.90 | 0.0000 | 0.87 | 0.84 | 0.90 | 0.93 | 0.87 | 0.98 | 0.0083 | 0.4807 | 0.4664 | 0.4950 | 0.0083180 |
| estatus_ocupacional3 | 0.93 | 0.90 | 0.97 | 0.0003 | 0.93 | 0.90 | 0.97 | 0.98 | 0.91 | 1.05 | 0.5720 | 0.4950 | 0.4776 | 0.5124 | 0.5719923 |
| freq_cons2 | 1.04 | 0.98 | 1.11 | 0.1713 | 1.04 | 0.98 | 1.11 | 1.02 | 0.89 | 1.18 | 0.7451 | 0.5060 | 0.4701 | 0.5418 | 0.7450705 |
| freq_cons3 | 1.09 | 1.03 | 1.17 | 0.0055 | 1.10 | 1.03 | 1.17 | 1.07 | 0.93 | 1.23 | 0.3500 | 0.5166 | 0.4818 | 0.5513 | 0.3500484 |
| freq_cons4 | 0.94 | 0.86 | 1.03 | 0.1653 | 0.93 | 0.85 | 1.02 | 0.96 | 0.82 | 1.12 | 0.5922 | 0.4897 | 0.4520 | 0.5274 | 0.5922131 |
| freq_cons5 | 0.98 | 0.86 | 1.11 | 0.7454 | 0.98 | 0.87 | 1.12 | 1.05 | 0.86 | 1.28 | 0.6256 | 0.5124 | 0.4625 | 0.5621 | 0.6255674 |
| freq_cons6 | 1.15 | 1.09 | 1.22 | 0.0000 | 1.16 | 1.09 | 1.23 | 1.09 | 0.96 | 1.24 | 0.2047 | 0.5208 | 0.4886 | 0.5528 | 0.2046730 |
| edad_al_ing | 0.98 | 0.98 | 0.98 | 0.0000 | 0.98 | 0.98 | 0.98 | 0.98 | 0.97 | 0.98 | 0.0000 | 0.4940 | 0.4933 | 0.4947 | 0.0000000 |
| cluster(id) | 1.00 | 1.00 | 1.00 | 0.2360 | 1.00 | 1.00 | 1.00 | 0.8406 | 0.5000 | 0.5000 | 0.5000 | 0.8405738 | |||
| strata(event)event=2 | 0.19 | 0.18 | 0.20 | 0.0000 | 0.21 | 0.20 | 0.22 | 0.0000 | 0.1718 | 0.1647 | 0.1790 | 0.0000000 | |||
| strata(event)event=3 | 0.23 | 0.21 | 0.24 | 0.0000 | 0.25 | 0.22 | 0.28 | 0.0000 | 0.1994 | 0.1822 | 0.2179 | 0.0000000 | |||
#predict
#pwp_gt_imp3
plot(predict(res_gt_3, type = "risk", x = "terap_dis", z = "event", arg="risk",
verbose = TRUE, exp = TRUE, pval = TRUE))## Error in h(simpleError(msg, call)): error in evaluating the argument 'x' in selecting a method for function 'plot': no applicable method for 'predict' applied to an object of class "c('data.table', 'data.frame')"