NLRP3

Table 1. Clinical characteristics of Transplant and Control subjets

var	Controls	Transplant	p
N	85	143
Age (years)	72.06 ± 6.19	55.87 ± 12.23	<0.001
Sex (Males)	51 (60.00)	92 (64.34)	0.608
Glucose (mg/dl)	109.06 ± 39.61	95.02 ± 31.32	0.004
Urea (mg/dl)	32.46 ± 9.43	44.98 ± 28.58	<0.001
Uric Acid (mg/dl)	4.63 ± 1.39	5.97 ± 1.70	<0.001
Ca (mg/dl)	9.45 ± 0.50	9.55 ± 0.86	0.313
Ph (mg/dl)	3.39 ± 0.58	3.53 ± 1.01	0.228
Total Cholesterol (mg/dl)	206.38 ± 39.88	193.66 ± 46.18	0.036
Tryglicerid (mg/dl)	131.44 ± 65.74	179.72 ± 93.38	<0.001
HDL Cholesterol (mg/dl)	59.02 ± 16.37	54.26 ± 16.95	0.040
LDL Cholesterol (mg/dl)	121.04 ± 34.21	103.15 ± 39.32	0.001
Ferritinemy (ng/ml)	72.00 (42.00 - 161.00)	104.00 (39.00 - 200.00)	0.125
CRP (mg/l)	2.46 (1.56 - 4.79)	5.00 (1.40 - 10.77)	0.010
serum Albumin (gr/dl)	3.95 ± 0.32	12.38 ± 14.80	<0.001
Hgb (gr/dl)	14.21 ± 1.54	12.86 ± 1.72	<0.001
Type 2 Diabetes	13 (15.29)	15 (13.89)	0.945
Hypertension	49 (57.65)	114 (79.72)	0.001

Table 2. Genotype and allele frequencies of NLRP3 rs10754558 and CARD8 rs2043211 in Controls and Transplant patients

var	Controls	Transplant	AOR	p
n	85	143
NLRP3 rs10754558 (%)
CC	39 (45.88)	33 (23.08)	1
CG	31 (36.47)	21 (14.69)	1.39 (0.33-5.83)	0.65
GG	15 (17.65)	89 (62.24)	12.14 (3.58-49.31)	< 0.001
C	109 (64.12)	59 (27.31)	1
G	61 (35.88)	157 (72.69)	6.31 (3.06-13.73)	< 0.001
CARD8 rs2043211 (%)
AA	44 (51.76)	23 (16.08)	1
TA	29 (34.12)	25 (17.48)	1.52 (0.40-6.02)	0.54
TT	12 (14.12)	95 (66.43)	25.12 (6.41-127.96)	< 0.001
A	117 (68.82)	49 (22.69)	1
T	53 (31.18)	167 (77.31)	7.75 (3.76-16.84)	< 0.001

Table 3. Genotype frequencies and AOR of NLRP3 rs10754558 and CARD8 rs2043211 in Dialysis and CKD patients

	Dialysis		CKD
	Frequency	AOR (95% CI)	Frequency	AOR (95% CI)
n	126		34
NLRP3 rs10754558 (%)
CC	33 (26.19)	1	11 (32.35)	1
CG	17 (13.49)	0.60 (0.27-1.31)	6 (17.65)	0.74 (0.23-2.26)
GG	76 (60.32)	6.09 (2.93-13.27)	17 (50.00)	3.87 (1.47-10.71)
C	83 (32.94)	1	28 (41.18)	1
G	169 (67.06)	3.62 (2.38-5.56)	40 (58.82)	2.54 (1.41-4.64)
CARD8 rs2043211 (%)
AA	12 (9.52)	1	4 (11.76)	1
TA	62 (49.21)	7.50 (3.48-17.18)	12 (35.29)	4.94 (1.49-19.82)
TT	52 (41.27)	15.72 (6.50-41.26)	18 (52.94)	18.19 (5.36-76.84)
A	86 (34.13)	1	20 (29.41)	1
T	166 (65.87)	4.29 (2.80-6.64)	48 (70.59)	5.60 (3.00-10.83)

Table S1. Clinical characteristics of Dialysis and CKD subjets

var	Dialysis	CKD
N	126	34
Age (years)	66.51 ± 15.75	71.97 ± 9.99
Sex (Males)	83 (65.87)	24 (70.59)
Glucose (mg/dl)	114.13 ± 42.22	127.14 ± 41.54
Urea (mg/dl)	61.79 ± 20.38	82.15 ± 46.82
Uric Acid (mg/dl)	5.85 ± 1.23	5.89 ± 1.35
Ca (mg/dl)	9.31 ± 0.81	9.22 ± 0.61
Ph (mg/dl)	4.78 ± 1.89	3.58 ± 0.86
Total Cholesterol (mg/dl)	164.19 ± 48.49	171.77 ± 39.78
Tryglicerid (mg/dl)	171.96 ± 96.41	177.59 ± 162.96
HDL Cholesterol (mg/dl)	44.78 ± 17.05	41.62 ± 15.98
LDL Cholesterol (mg/dl)	85.52 ± 40.69	86.60 ± 33.64
Ferritinemy (ng/ml)	298.50 (63.50 - 598.25)	49.50 (31.75 - 96.25)
CRP (mg/l)	7.18 (1.10 - 14.33)	0.60 (0.20 - 6.95)
serum Albumin (gr/dl)	3.31 ± 0.50	14.07 ± 20.92
Hgb (gr/dl)	11.58 ± 1.83	12.62 ± 2.12
Type 2 Diabetes	30 (23.81)	9 (52.94)
Hypertension	81 (64.29)	14 (82.35)