###Introduction #This code compiles summary information about the gene OAS1 (oligoadenylate synthetase 1). This gene encodes a protein that synthesizes soligoadenylates which activates RNase L resulting in viral RNA degradation and the inhibition of viral replication(NCBI).

###Resources / References Key information use to make this script can be found here:

Refseq Gene: https://www.ncbi.nlm.nih.gov/gene/4938 Refseq Homologene: https://www.ncbi.nlm.nih.gov/homologene?LinkName=gene_homologene&from_uid=4938

PDB: https://www.rcsb.org/search?request=%7B%22query%22%3A%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22full_text%22%2C%22parameters%22%3A%7B%22value%22%3A%22OAS1%22%7D%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%5D%2C%22logical_operator%22%3A%22and%22%2C%22label%22%3A%22full_text%22%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%2C%22return_type%22%3A%22entry%22%2C%22request_options%22%3A%7B%22pager%22%3A%7B%22start%22%3A0%2C%22rows%22%3A25%7D%2C%22scoring_strategy%22%3A%22combined%22%2C%22sort%22%3A%5B%7B%22sort_by%22%3A%22score%22%2C%22direction%22%3A%22desc%22%7D%5D%7D%2C%22request_info%22%3A%7B%22query_id%22%3A%2265c62d8b735b722847f30da285e0e2af%22%7D%7D

ALPHAFOLD: https://alphafold.ebi.ac.uk/entry/P00973

UniProt: https://www.uniprot.org/uniprot/P00973

Other resources consulted includes:

Neanderthal genome: http://neandertal.ensemblgenomes.org/index.html Other interesting resources and online tools include:

REPPER: https://toolkit.tuebingen.mpg.de/jobs/7803820 Sub-cellular locations prediction: https://wolfpsort.hgc.jp/

###Data Preparation

Accession Numbers

Accession numbers were obtained from RefSeq, Refseq Homlogene, UniProt and PDB. UniProt accession numbers can be found by searching for the gene name. PDB accessions can be found by searching with a UniProt accession or a gene name, though many proteins are not in PDB. The the Neanderthal genome database was searched but did not yield sequence information on.

A protein BLAST search #(https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastp&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome) was carried out excluding vertebrates to determine if it occurred outside of vertebreates. The gene does not appear in non-vertebrates and so a second search was conducted to exclude mammals.

# optional
# HGNChelper::checkGeneSymbols(x = c("OAS1"))

Accession number table

Not available: Neanderthal

Does not occur: Outside of vertebrates

 NBCI.Protein.Accession<-c("NP_058132.2","NP_001077418.1","NP_001075958.1","XP_031299144.1", "NP_620268.2","NP_001025017.2","NP_999468.2", "NP_001041596.1", " XP_003952355.1","AYA44748.1")

UniProt.ID <-c("P00973","F7EI59","H9GZX8", "A0A5N4C9Z4", "Q05961", "A0A4W2IHE3","Q29599", "F1PLW6","H2R747", "H2NIQ7")

Scientific.Name <-c("Homo sapiens", "Macaca mulatta","Equus caballus","Camelus dromedarius", "Pan troglodytes","Rattus norvegicus","Pongo pygmaeus", "Bos taurus", "Sus scrofa","Canis familiaris")

Common.Name <-c("Human", "Rhesus Macaque", "Horse","Dromedary","Chimpanzee","Norwegian Rat", "Sumatran Orangutan", "Cattle", "Pig", "Dog")

Gene.Name <-c("OAS1")

PDB.ID <- c("N/A","N/A","N/A","N/A","N/A","N/A","N/A","N/A","N/A","N/A","N/A")


#Convert vector information into a table
OAS1_table <- data.frame(Scientific.Name = Scientific.Name, NBCI.Protein.Accession = NBCI.Protein.Accession, UniProt.ID = UniProt.ID, Common.Name = Common.Name , Gene.Name = Gene.Name)

NBCI.Protein.Accession

##  [1] "NP_058132.2"     "NP_001077418.1"  "NP_001075958.1"  "XP_031299144.1" 
##  [5] "NP_620268.2"     "NP_001025017.2"  "NP_999468.2"     "NP_001041596.1" 
##  [9] " XP_003952355.1" "AYA44748.1"

UniProt.ID

##  [1] "P00973"     "F7EI59"     "H9GZX8"     "A0A5N4C9Z4" "Q05961"    
##  [6] "A0A4W2IHE3" "Q29599"     "F1PLW6"     "H2R747"     "H2NIQ7"

Scientific.Name

##  [1] "Homo sapiens"        "Macaca mulatta"      "Equus caballus"     
##  [4] "Camelus dromedarius" "Pan troglodytes"     "Rattus norvegicus"  
##  [7] "Pongo pygmaeus"      "Bos taurus"          "Sus scrofa"         
## [10] "Canis familiaris"

Common.Name

##  [1] "Human"              "Rhesus Macaque"     "Horse"             
##  [4] "Dromedary"          "Chimpanzee"         "Norwegian Rat"     
##  [7] "Sumatran Orangutan" "Cattle"             "Pig"               
## [10] "Dog"

Gene.Name

## [1] "OAS1"

pander(OAS1_table)

Table continues below
Scientific.Name	NBCI.Protein.Accession	UniProt.ID	Common.Name
Homo sapiens	NP_058132.2	P00973	Human
Macaca mulatta	NP_001077418.1	F7EI59	Rhesus Macaque
Equus caballus	NP_001075958.1	H9GZX8	Horse
Camelus dromedarius	XP_031299144.1	A0A5N4C9Z4	Dromedary
Pan troglodytes	NP_620268.2	Q05961	Chimpanzee
Rattus norvegicus	NP_001025017.2	A0A4W2IHE3	Norwegian Rat
Pongo pygmaeus	NP_999468.2	Q29599	Sumatran Orangutan
Bos taurus	NP_001041596.1	F1PLW6	Cattle
Sus scrofa	XP_003952355.1	H2R747	Pig
Canis familiaris	AYA44748.1	H2NIQ7	Dog

Gene.Name
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1

# Finished Table

pander::pander(OAS1_table)

Table continues below
Scientific.Name	NBCI.Protein.Accession	UniProt.ID	Common.Name
Homo sapiens	NP_058132.2	P00973	Human
Macaca mulatta	NP_001077418.1	F7EI59	Rhesus Macaque
Equus caballus	NP_001075958.1	H9GZX8	Horse
Camelus dromedarius	XP_031299144.1	A0A5N4C9Z4	Dromedary
Pan troglodytes	NP_620268.2	Q05961	Chimpanzee
Rattus norvegicus	NP_001025017.2	A0A4W2IHE3	Norwegian Rat
Pongo pygmaeus	NP_999468.2	Q29599	Sumatran Orangutan
Bos taurus	NP_001041596.1	F1PLW6	Cattle
Sus scrofa	XP_003952355.1	H2R747	Pig
Canis familiaris	AYA44748.1	H2NIQ7	Dog

Gene.Name
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1
OAS1

Data prepartation

Download sequences

All sequences were downloaded using a wrapper compbio4all::entrez_fetch_list() which uses rentrez::entrez_fetch() to access NCBI databases.

# Downlaod Fasta Sequences

# Human (Homo sapiens)
HumanOAS1_FASTA <- rentrez::entrez_fetch(id = " NP_058132.2", db = "protein", rettype="fasta")


# Rhesus macaque  (Macaca mulatta)
RhesusOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = " NP_001077418.1", 
                          rettype = "fasta")

# Dromedary (Camelus dromedary)
CamelOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = " XP_031299144.1", 
                          rettype = "fasta")

# Chimpanzee (Pan troglodytes)
ChimpOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = "NP_620268.2", 
                          rettype = "fasta")

# Norwegian Rat (Rattus norwegicus)
NorwayRatOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = "NP_001025017.2",
                          rettype = "fasta")

# Sumatran Orangutan (P. troglodytes)
OrangutanOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = "XP_016809250", 
                          rettype = "fasta")

# Horse (Equus caballus)
HorseOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = "NP_001075958.1", 
                          rettype = "fasta")

# Cattle (Bos taurus)
CattleOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = "NP_001041596.1", 
                          rettype = "fasta")

# Pig (Sus scrofa)
PigOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = "XP_003952355.1", 
                          rettype = "fasta")

# Dog (Canis familiaris)
CanisOAS1_FASTA <- entrez_fetch_list(db = "protein", 
                          id = "AYA44748.1", 
                          rettype = "fasta")


OAS1s_list <- c(HumanOAS1_FASTA, RhesusOAS1_FASTA, CamelOAS1_FASTA, ChimpOAS1_FASTA, NorwayRatOAS1_FASTA,  OrangutanOAS1_FASTA, HorseOAS1_FASTA, CattleOAS1_FASTA,  PigOAS1_FASTA, CanisOAS1_FASTA)

#The first entry
OAS1s_list [[1]]

## [1] ">NP_058132.2 2'-5'-oligoadenylate synthase 1 isoform 1 [Homo sapiens]\nMMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTL\nRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQ\nLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIR\nLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKN\nPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESN\nSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL\n\n"

# Cleaning for Later
HumanOAS1_string <- fasta_cleaner(HumanOAS1_FASTA, parse = F)
RhesesOAS1_string <- fasta_cleaner(RhesusOAS1_FASTA,
                               parse = F)
HorseOAS1_string <- fasta_cleaner(HorseOAS1_FASTA,
                               parse = F)
NorwayRatOAS1_string <- fasta_cleaner(NorwayRatOAS1_FASTA,
                               parse = F)
CanisOAS1_string <- fasta_cleaner(CanisOAS1_FASTA,
                               parse = F)
PigOAS1_string <- fasta_cleaner(PigOAS1_FASTA,
                               parse = F)
CattleOAS1_string <- fasta_cleaner(CattleOAS1_FASTA,
                               parse = F)
OrangutanOAS1_string <- fasta_cleaner(OrangutanOAS1_FASTA,
                               parse = F) 
CamelOAS1_string <- fasta_cleaner(CamelOAS1_FASTA,
                               parse = F)
ChimpOAS1_string <- fasta_cleaner(ChimpOAS1_FASTA,
                               parse = F)

Initial data cleaning

Remove FASTA header

for(i in 1:length(OAS1s_list)){
 OAS1s_list[[i]] <- compbio4all::fasta_cleaner(OAS1s_list[[i]], parse = F)
}
OAS1s_list

## [[1]]
## [1] "MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL"
## 
## $` NP_001077418.1`
## [1] "MMDLITTPAKSLDKFIEDYLLPDTHFRMQINHAIDIICGFLKERCFRGSSYTVRVSKVVKGGSSGKGTSLRGRSDADLVVFLSPLTTFQDQLNRRGEFIREIRKQLEACQRERAFSVKFEVQAPRRDNPRALSFVLSSPQLGEGVEFDVLPAFDALGQLTGGYKPDPQIYVELIEECVSLQKEGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSTETDFNTARGFRTVLELVINYQQLCVYWTKYYDFQNPIIGKYLSRQLRKPRPVILDPADPTGNLGGGDTKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESDSEDDESYDPRMYQQHGYIQTYECPHFSHSPSILQAASTPQAEENWTCTIL"
## 
## $` XP_031299144.1`
## [1] "MALRDTRANQLDKFIEDNLLPDTPFRTQVREAVDIICTFLKERCFRGAAHPVRVSKVVKGGSSGKGTTLRGRSDADLVVFLTNLKSFQEQLLHRGEFIQEITRQLEACQREKRFKVKFEIHNSSRANPRALSFMLTSPQLDQGVEFDVLPAFDALGQLTRGYRPDPKVYIQLIEECESLGKEGEFSPCFTELQRAFLRDRPTKLKSLIRLVKHWYQECKRRNGKEGALPPQYALELLTVYAWERGSGSPEFNTAQGFRTVLELVRKHQDLCIYWENYYSLENPIIGRYLKKQLGKPRPVILDPADPTGNVAGRDPGSWWLLAQEAATWLRYPCLTECNGSPVSTWEVQEALPARSACTGSPARSIVMALRDTRANQLDKFIEDNLLPDTPFRTQVREAVDIICTFLKERCFRGAAHPVRVSKVVKGGSSGKGTTLRGRSDADLVVFLTNLKSFQEQLCRRGEFIQEITRQLEACHREKKFKVMFKIHNSSYANPRALSFALTSPQLDQGVEFDVLPAFDALGQLTRGYRPDPKVYIQLIEECESLGKEGEFSPCFTELQRAFLRDRPTKLKSLIRLVKHWYQECKQQLGKPLPPQYALELLTVYAWEQGSRKTEFNTAQGFRTVLELVRKHQDLCIYWENYYSLENPIIGRYLKKQLRKPRPVILDPADPTGNIGGGDPRSWQRLAEEATAWLSYPCLKKWDGSPVDSWHVPPRKDSYWTHEACDDCQHWEFSPRPITLQGGRPPLEEENWSCVIL"
## 
## $NP_620268.2
## [1] "MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSAINVLCDFLKERCFRDTVHPVRVSKVVKGGSSGKGTTLKGKSDADLVVFLNNFTSFEDQLNRRGEFIKEIKKQLYEVQREKHFRVKFEVQSSWWPNPRALSFKLSAPHLQQEVEFDVLPAYDVLGHVSLYSNPDPKIYTILISECISLGKEGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQLCKEKLGKPLPPQYALELLTVYAWERGNGITEFNTAQGFRTILELVTKYQQLRIYWTKYYDFQHPDVSKYLHRQLRKSRPVILDPADPTGNVAGGNQEGWRRLASEARLWLQYPCFMNRGGSPVSSWEVPVDEAWSCILL"
## 
## $NP_001025017.2
## [1] "MKKLRKTQANKLDKFIKDHLLPHEEFQRQVNEAIDIICTFLKETCFQESTHPVRVSKVVKGGSSGKGTTLKDLSDADLVVFLTNLTSFQENFEHRVRFIKEIRRQLEAYQRQKTFEVEFEVLKQRKRKRRALSFVLRSPWFCQGVKFDVLPAFDALAKYSQSQAQVTEDYKPNPQIYVQLIQECENLRREGEFSPCFTELQRAFLKERPAKLKSLIRLVKHWYQQCKKRHGKKLPSQYALELLTIYAWEQEGSKTKFRTAEGFRTVLELVLKHQDLCIYWKKYYDFENPIITQCLKRQLEKPRPVILDPADPTGNVAGREPQRWQLLAQEVTVWLKYSCCKNRNGSPVSPWNVPVTPPHYLSDLILMAC"
## 
## $XP_016809250
## [1] "MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGRKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSVMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFVQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF"
## 
## $NP_001075958.1
## [1] "MELQKTPARNLDKFIEDYLLPDTRFRRQVREAIDIICSFLKERCFRGAVPPVRVSKVVKGGSSGKGTTLRGRSDADLVVFLDYLTSFREQFERRAEFIKEIRRQLEACQREKRFDVEFEVQGQQWARPRALSFVLTSPQLNEGVEFDVLPAFDVLGQVTTSYRPDPDIYVLLIKECQSLGKEGEFSPCFTELQRAFLRQRPTKLKSLIRLVKHWYQKCKDKLGKPLPAQYALELLTVYAWEQGSRQTEFNTAQGFRTVLELVLKYQQLCIYWTKYYNFDDPVIGQYLKRQLKKPRPVILDPADPTGNVGGGDPRSWPRLAQEARAWLSYPCFKNWDGSPVGSWDVGPEEDSEDDTLTWAERAYYQCDHGRRPEFPQTGSTPQRASAPDAEENWTCTIL"
## 
## $NP_001041596.1
## [1] "MPELKDTPAKDLDRFIENYLLPDTQFRRQVKEAIHIISTFLKERCFQGAAHPVRVSKVVKGGSSGKGTTLRGRSDADLVVFLNNLKSFQEQLEKRGQFIWEIKRQLEACQREETFEVYFEVQSLQWEKPRALSFVLKSPQLGEGVEFDVLPAFDVLGQWTNNHRPNPEVYIKLIQECENRGTEGEFSTCFTELQRDFLRQRPTKVKSLIRLVKHWYQKCKQKLGKPLPPQYALELLTVYAWERGNHQTEFITAQGFQTVLKLVLNYQQLCIHWTKYYNFETPIIKQYLMRQLAKPRPVILDPADPTGNVAGRDTYGWQRLAQEARVWLSYPCFKKWDGSPVGSWDVLVKPASSLM"
## 
## $XP_003952355.1
## [1] "MMDLRNTPAKSLDKFIEDYLLPDKCFRKQINHAIDIICGFLKERCFQGSSYPVHVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQREERAFSVKFEVQAPRWDNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTDGYKPDPQIYVKLIEECTYLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWEQGSMETDFNTAQEFRTVLELVINYQQLCIYWTKYYDFENPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNXDGSPVSSWILLAESDSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL"
## 
## $AYA44748.1
## [1] "MMDLRNTPAKSLDKFIEDYLLPDTHFRMQINHAIDTICGFLKERCFRGSSYPVRVSKVVKGGSSGKGTALRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRKQLEACQRERAFSVKFEVQAPRWDNPRALSFVLSSFQLREGVEFDVLPAFDALGQLTGGYKPDPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFENPIIKKYLSRQLRKPRPVILDPADPTGNLGGGDPIGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESDSEDDETYDPRMYPKYGYIRTHEYSHFSHSPSTLQAASTPQAEENWTCTIL"

### General Protein Information

key domains and other features using "drawProteins" package
For code see https://rpubs.com/lowbrowR/drawProtein

```r
P00973_Human <-drawProteins::get_features("P00973")

## [1] "Download has worked"

protein_human_df<-drawProteins::feature_to_dataframe(P00973_Human)
protein_human_df

##                     type
## featuresTemp       CHAIN
## featuresTemp.1    REGION
## featuresTemp.2    REGION
## featuresTemp.3     METAL
## featuresTemp.4     METAL
## featuresTemp.5     METAL
## featuresTemp.6   BINDING
## featuresTemp.7   BINDING
## featuresTemp.8   BINDING
## featuresTemp.9   BINDING
## featuresTemp.10     SITE
## featuresTemp.11  VAR_SEQ
## featuresTemp.12  VAR_SEQ
## featuresTemp.13  VAR_SEQ
## featuresTemp.14  VAR_SEQ
## featuresTemp.15  VAR_SEQ
## featuresTemp.16  VARIANT
## featuresTemp.17  VARIANT
## featuresTemp.18  VARIANT
## featuresTemp.19  VARIANT
## featuresTemp.20  VARIANT
## featuresTemp.21  VARIANT
## featuresTemp.22  MUTAGEN
## featuresTemp.23  MUTAGEN
## featuresTemp.24  MUTAGEN
## featuresTemp.25  MUTAGEN
## featuresTemp.26  MUTAGEN
## featuresTemp.27  MUTAGEN
## featuresTemp.28  MUTAGEN
## featuresTemp.29  MUTAGEN
## featuresTemp.30 CONFLICT
## featuresTemp.31 CONFLICT
## featuresTemp.32 CONFLICT
## featuresTemp.33 CONFLICT
## featuresTemp.34 CONFLICT
## featuresTemp.35 CONFLICT
## featuresTemp.36 CONFLICT
## featuresTemp.37 CONFLICT
## featuresTemp.38 CONFLICT
## featuresTemp.39     TURN
## featuresTemp.40    HELIX
## featuresTemp.41    HELIX
## featuresTemp.42    HELIX
## featuresTemp.43     TURN
## featuresTemp.44   STRAND
## featuresTemp.45    HELIX
## featuresTemp.46     TURN
## featuresTemp.47   STRAND
## featuresTemp.48    HELIX
## featuresTemp.49     TURN
## featuresTemp.50   STRAND
## featuresTemp.51   STRAND
## featuresTemp.52     TURN
## featuresTemp.53   STRAND
## featuresTemp.54   STRAND
## featuresTemp.55    HELIX
## featuresTemp.56     TURN
## featuresTemp.57    HELIX
## featuresTemp.58    HELIX
## featuresTemp.59     TURN
## featuresTemp.60    HELIX
## featuresTemp.61    HELIX
## featuresTemp.62    HELIX
## featuresTemp.63    HELIX
## featuresTemp.64   STRAND
## featuresTemp.65    HELIX
## featuresTemp.66   STRAND
## featuresTemp.67   STRAND
## featuresTemp.68   STRAND
## featuresTemp.69    HELIX
## featuresTemp.70    HELIX
## featuresTemp.71 CONFLICT
##                                                             description begin
## featuresTemp                            2'-5'-oligoadenylate synthase 1     1
## featuresTemp.1                                   Interaction with dsRNA    13
## featuresTemp.2                                   Interaction with dsRNA   200
## featuresTemp.3                                     Magnesium; catalytic    75
## featuresTemp.4                                     Magnesium; catalytic    77
## featuresTemp.5                                     Magnesium; catalytic   148
## featuresTemp.6                                                      ATP    63
## featuresTemp.7                                                      ATP   210
## featuresTemp.8                                                      ATP   213
## featuresTemp.9                                                      ATP   229
## featuresTemp.10                                  Interaction with dsRNA   158
## featuresTemp.11                                                    NONE   347
## featuresTemp.12                                                    NONE   347
## featuresTemp.13                                                    NONE   347
## featuresTemp.14                                                    NONE   361
## featuresTemp.15                                                    NONE   365
## featuresTemp.16                                      in dbSNP:rs1050994    31
## featuresTemp.17                                      in dbSNP:rs4767022   127
## featuresTemp.18                                      in dbSNP:rs1131454   162
## featuresTemp.19                                      in dbSNP:rs1131476   352
## featuresTemp.20                                     in dbSNP:rs35919998   354
## featuresTemp.21                                      in dbSNP:rs1051042   361
## featuresTemp.22                              Decreased enzyme activity.    66
## featuresTemp.23            Loss of activity; when associated with A-77.    75
## featuresTemp.24            Loss of activity; when associated with A-75.    77
## featuresTemp.25                       Strongly reduced enzyme activity.   148
## featuresTemp.26                                Loss of enzyme activity.   233
## featuresTemp.27 Loss of activity; when associated with A-332 and A-333.   331
## featuresTemp.28 Loss of activity; when associated with A-331 and A-333.   332
## featuresTemp.29 Loss of activity; when associated with A-331 and A-332.   333
## featuresTemp.30                                     in Ref. 4; AAA39857    18
## featuresTemp.31                                    in Ref. 12; AAH71981   111
## featuresTemp.32                   in Ref. 1; AAB59552/AAB59553/CAA26633   115
## featuresTemp.33                                    in Ref. 10; BAD96726   120
## featuresTemp.34                                     in Ref. 4; AAA39858   122
## featuresTemp.35                                     in Ref. 4; AAA39857   157
## featuresTemp.36                                     in Ref. 4; AAA39858   176
## featuresTemp.37                                     in Ref. 2; CAB51602   295
## featuresTemp.38                                     in Ref. 2; CAB51602   315
## featuresTemp.39                                                    NONE     4
## featuresTemp.40                                                    NONE     9
## featuresTemp.41                                                    NONE    12
## featuresTemp.42                                                    NONE    24
## featuresTemp.43                                                    NONE    44
## featuresTemp.44                                                    NONE    55
## featuresTemp.45                                                    NONE    62
## featuresTemp.46                                                    NONE    71
## featuresTemp.47                                                    NONE    76
## featuresTemp.48                                                    NONE    88
## featuresTemp.49                                                    NONE   112
## featuresTemp.50                                                    NONE   116
## featuresTemp.51                                                    NONE   132
## featuresTemp.52                                                    NONE   139
## featuresTemp.53                                                    NONE   145
## featuresTemp.54                                                    NONE   161
## featuresTemp.55                                                    NONE   167
## featuresTemp.56                                                    NONE   183
## featuresTemp.57                                                    NONE   187
## featuresTemp.58                                                    NONE   191
## featuresTemp.59                                                    NONE   196
## featuresTemp.60                                                    NONE   203
## featuresTemp.61                                                    NONE   229
## featuresTemp.62                                                    NONE   251
## featuresTemp.63                                                    NONE   265
## featuresTemp.64                                                    NONE   278
## featuresTemp.65                                                    NONE   281
## featuresTemp.66                                                    NONE   293
## featuresTemp.67                                                    NONE   297
## featuresTemp.68                                                    NONE   303
## featuresTemp.69                                                    NONE   313
## featuresTemp.70                                                    NONE   330
## featuresTemp.71       in Ref. 4; AAA39858, 6; AAW63050 and 16; CAA26497   397
##                 end length accession  entryName taxid order
## featuresTemp    400    399    P00973 OAS1_HUMAN  9606     1
## featuresTemp.1   60     47    P00973 OAS1_HUMAN  9606     1
## featuresTemp.2  210     10    P00973 OAS1_HUMAN  9606     1
## featuresTemp.3   75      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.4   77      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.5  148      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.6   63      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.7  210      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.8  213      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.9  229      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.10 158      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.11 400     53    P00973 OAS1_HUMAN  9606     1
## featuresTemp.12 364     17    P00973 OAS1_HUMAN  9606     1
## featuresTemp.13 360     13    P00973 OAS1_HUMAN  9606     1
## featuresTemp.14 400     39    P00973 OAS1_HUMAN  9606     1
## featuresTemp.15 400     35    P00973 OAS1_HUMAN  9606     1
## featuresTemp.16  31      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.17 127      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.18 162      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.19 352      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.20 354      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.21 361      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.22  66      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.23  75      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.24  77      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.25 148      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.26 233      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.27 331      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.28 332      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.29 333      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.30  18      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.31 111      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.32 115      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.33 120      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.34 122      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.35 157      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.36 176      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.37 295      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.38 315      0    P00973 OAS1_HUMAN  9606     1
## featuresTemp.39   6      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.40  11      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.41  19      7    P00973 OAS1_HUMAN  9606     1
## featuresTemp.42  43     19    P00973 OAS1_HUMAN  9606     1
## featuresTemp.43  46      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.44  61      6    P00973 OAS1_HUMAN  9606     1
## featuresTemp.45  66      4    P00973 OAS1_HUMAN  9606     1
## featuresTemp.46  73      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.47  84      8    P00973 OAS1_HUMAN  9606     1
## featuresTemp.48 111     23    P00973 OAS1_HUMAN  9606     1
## featuresTemp.49 114      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.50 118      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.51 137      5    P00973 OAS1_HUMAN  9606     1
## featuresTemp.52 141      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.53 152      7    P00973 OAS1_HUMAN  9606     1
## featuresTemp.54 163      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.55 179     12    P00973 OAS1_HUMAN  9606     1
## featuresTemp.56 186      3    P00973 OAS1_HUMAN  9606     1
## featuresTemp.57 190      3    P00973 OAS1_HUMAN  9606     1
## featuresTemp.58 195      4    P00973 OAS1_HUMAN  9606     1
## featuresTemp.59 200      4    P00973 OAS1_HUMAN  9606     1
## featuresTemp.60 223     20    P00973 OAS1_HUMAN  9606     1
## featuresTemp.61 243     14    P00973 OAS1_HUMAN  9606     1
## featuresTemp.62 263     12    P00973 OAS1_HUMAN  9606     1
## featuresTemp.63 267      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.64 280      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.65 290      9    P00973 OAS1_HUMAN  9606     1
## featuresTemp.66 295      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.67 300      3    P00973 OAS1_HUMAN  9606     1
## featuresTemp.68 308      5    P00973 OAS1_HUMAN  9606     1
## featuresTemp.69 326     13    P00973 OAS1_HUMAN  9606     1
## featuresTemp.70 332      2    P00973 OAS1_HUMAN  9606     1
## featuresTemp.71 397      0    P00973 OAS1_HUMAN  9606     1

PROTEIN DIAGRAM

protein_human_df <- drawProteins::feature_to_dataframe(P00973_Human)

my_canvasHuman <- draw_canvas(protein_human_df)  
my_canvasHuman <- draw_chains(my_canvasHuman, protein_human_df, 
                         label_size = 2.5)
my_canvasHuman<- draw_domains(my_canvasHuman, protein_human_df)

my_canvasHuman <- draw_recept_dom(my_canvasHuman, protein_human_df)

my_canvasHuman <- draw_regions(my_canvasHuman, protein_human_df)

my_canvasHuman <- draw_motif(my_canvasHuman, protein_human_df)
my_canvasHuman<- draw_phospho(my_canvasHuman, protein_human_df)
my_canvasHuman <- draw_repeat(my_canvasHuman, protein_human_df)

my_canvasHuman <- draw_folding(my_canvasHuman,protein_human_df)

my_canvasHuman

Draw Dotplot

Data prep

P00973_FASTA <- rentrez::entrez_fetch(id = "P00973", db = "protein", rettype = "fasta")

P00973_Vector <- fasta_cleaner(P00973_FASTA, parse = T)

Create a 2x2 panel to show different values for dotPlots settings

 par(mfrow = c(2,2), 
     mar = c(0,0,2,1))

#plot 1

dotPlot(P00973_Vector, P00973_Vector, 
        wsize = 1, 
        nmatch = 1, 
        main = "wsize=1,nmatch=1")

#plot 2

dotPlot(P00973_Vector, P00973_Vector, 
        wsize = 10, 
        nmatch = 1, 
        main = "wsize=10, nmatch=1")

#plot 3

dotPlot(P00973_Vector, P00973_Vector, 
        wsize =10, 
        nmatch = 5, 
        main = "wsize=10, nmatch=5",)

#plot4

dotPlot(P00973_Vector, P00973_Vector, 
        wsize = 20, 
        nmatch = 5, 
        main = "wsize=20, nmatch=5")

# Ideal Box Plot Settings

#Create a single large plot with the best version of the plot

dotPlot(P00973_Vector, P00973_Vector, 
        wsize = 18, 
        nmatch = 3, 
        main = "Ideal dotPlot Settings")

Protein Properties Compiled From Databases

A major feature from Pfam (domain, motif) and URL of entry

Presence of disorganized regons from DisProt, Disprot accession, and URL of entry
Presence of tandem repeats from RepeatsDB and URL of entry (see RepeatsDB) -Subcellular location from Uniport
Protein secondary structural classfifcations from PDB if available.

Protein_Databases <- c("Pfam", "DisProt", "RepeatsDB", "UniProt sub-cellular locations", "PDB secondary structure location")

Protein_Properties <- c("OAS1 protein in humans has two named domains, OAC1_C, and  NTP_transf_2.", "NA", "NA", "intracellular protein found in the nucleus, ER, cytosol, and mitochondria", "Alpha helices and beta sheets")

URL_of_Entry <- c("http://pfam.xfam.org/protein/P00973", "NA", "NA", "https://www.uniprot.org/uniprot/P00973#subcellular_location", "http://www.cathdb.info/version/latest/superfamily/1.10.1410.20/classification")

Protein_Props_Table<- data.frame(Protein_Databases, Protein_Properties, URL_of_Entry)

pander::pander(Protein_Props_Table)

Table continues below
Protein_Databases	Protein_Properties
Pfam	OAS1 protein in humans has two named domains, OAC1_C, and NTP_transf_2.
DisProt	NA
RepeatsDB	NA
UniProt sub-cellular locations	intracellular protein found in the nucleus, ER, cytosol, and mitochondria
PDB secondary structure location	Alpha helices and beta sheets

URL_of_Entry
http://pfam.xfam.org/protein/P00973
NA
NA
https://www.uniprot.org/uniprot/P00973#subcellular_location
http://www.cathdb.info/version/latest/superfamily/1.10.1410.20/classification

Protein Feature Prediction

Multivariate statistcal techniques were used to confirm the information about protein structure and location in the line database.

Uniprot (which uses http://www.csbio.sjtu.edu.cn/bioinf/Cell-PLoc-2/ I believe) indicates that the protein is a membrane-bound protein, particularlly in the ER.

# enter once, then again
aa.1.1 <- c("A","R","N","D","C","Q","E","G","H","I",
            "L","K","M","F","P","S","T","W","Y","V")
aa.1.2 <- c("A","R","N","D","C","Q","E","G","H","I",
            "L","K","M","F","P","S","T","W","Y","V")

Make vectors with the frequency of each amino acid in the databse of proteins of each type used by Chou. Chou’s table lists totals so I do logical checks again the total he gives and the total in my vector.

Alpha

# alpha proteins
alpha <- c(285, 53, 97, 163, 22, 67, 134, 197, 111, 91, 
           221, 249, 48, 123, 82, 122, 119, 33, 63, 167)

# check against chou's total
sum(alpha) == 2447

## [1] TRUE

# beta proteins
beta <- c(203, 67, 139, 121, 75, 122, 86, 297, 49, 120, 
          177, 115, 16, 85, 127, 341, 253, 44, 110, 229)

# check against chou's total
sum(beta) == 2776

## [1] TRUE

# alpha + beta
a.plus.b <- c(175, 78, 120, 111, 74, 74, 86, 171, 33, 93,
              110, 112, 25, 52, 71, 126, 117, 30, 108, 123)
sum(a.plus.b) == 1889

## [1] TRUE

# alpha/beta
a.div.b <- c(361, 146, 183, 244, 63, 114, 257, 377, 107, 239, 
             339, 321, 91, 158, 188, 327, 238, 72, 130, 378)
sum(a.div.b) == 4333

## [1] TRUE

Chou and Chang’s table 5

data.frame(aa.1.1, alpha, beta, a.plus.b, a.div.b)

##    aa.1.1 alpha beta a.plus.b a.div.b
## 1       A   285  203      175     361
## 2       R    53   67       78     146
## 3       N    97  139      120     183
## 4       D   163  121      111     244
## 5       C    22   75       74      63
## 6       Q    67  122       74     114
## 7       E   134   86       86     257
## 8       G   197  297      171     377
## 9       H   111   49       33     107
## 10      I    91  120       93     239
## 11      L   221  177      110     339
## 12      K   249  115      112     321
## 13      M    48   16       25      91
## 14      F   123   85       52     158
## 15      P    82  127       71     188
## 16      S   122  341      126     327
## 17      T   119  253      117     238
## 18      W    33   44       30      72
## 19      Y    63  110      108     130
## 20      V   167  229      123     378

pander(data.frame(aa.1.1, alpha, beta, a.plus.b, a.div.b))

aa.1.1	alpha	beta	a.plus.b	a.div.b
A	285	203	175	361
R	53	67	78	146
N	97	139	120	183
D	163	121	111	244
C	22	75	74	63
Q	67	122	74	114
E	134	86	86	257
G	197	297	171	377
H	111	49	33	107
I	91	120	93	239
L	221	177	110	339
K	249	115	112	321
M	48	16	25	91
F	123	85	52	158
P	82	127	71	188
S	122	341	126	327
T	119	253	117	238
W	33	44	30	72
Y	63	110	108	130
V	167	229	123	378

Protein Fold Calcualtions + Data Frame

alpha.prop <- alpha/sum(alpha)
beta.prop <- beta/sum(beta)
a.plus.b.prop <- a.plus.b/sum(a.plus.b)
a.div.b <- a.div.b/sum(a.div.b)


#dataframe
aa.prop <- data.frame(alpha.prop,
                      beta.prop,
                      a.plus.b.prop,
                      a.div.b)
#row labels
row.names(aa.prop) <- aa.1.1

pander(aa.prop)

	alpha.prop	beta.prop	a.plus.b.prop	a.div.b
A	0.1165	0.07313	0.09264	0.08331
R	0.02166	0.02414	0.04129	0.03369
N	0.03964	0.05007	0.06353	0.04223
D	0.06661	0.04359	0.05876	0.05631
C	0.008991	0.02702	0.03917	0.01454
Q	0.02738	0.04395	0.03917	0.02631
E	0.05476	0.03098	0.04553	0.05931
G	0.08051	0.107	0.09052	0.08701
H	0.04536	0.01765	0.01747	0.02469
I	0.03719	0.04323	0.04923	0.05516
L	0.09031	0.06376	0.05823	0.07824
K	0.1018	0.04143	0.05929	0.07408
M	0.01962	0.005764	0.01323	0.021
F	0.05027	0.03062	0.02753	0.03646
P	0.03351	0.04575	0.03759	0.04339
S	0.04986	0.1228	0.0667	0.07547
T	0.04863	0.09114	0.06194	0.05493
W	0.01349	0.01585	0.01588	0.01662
Y	0.02575	0.03963	0.05717	0.03
V	0.06825	0.08249	0.06511	0.08724

Download Focal Gene

# Function to convert a table into a vector
table_to_vector <- function(table_x){
  table_names <- attr(table_x, "dimnames")[[1]]
  table_vect <- as.vector(table_x)
  names(table_vect) <- table_names
  return(table_vect)
}
#Fetch
NP_058132.2 <- rentrez::entrez_fetch(id = "NP_058132.2", db = "protein", rettype = "fasta")

# clean 
NP_058132.2_clean <- compbio4all::fasta_cleaner(NP_058132.2, parse = T)


OAS1_human_freq_table <- table(NP_058132.2_clean)/length(NP_058132.2_clean)

OAS1_human_freq_table

## NP_058132.2_clean
##      A      C      D      E      F      G      H      I      K      L      M 
## 0.0525 0.0275 0.0550 0.0625 0.0500 0.0650 0.0150 0.0450 0.0650 0.1075 0.0100 
##      N      P      Q      R      S      T      V      W      Y 
## 0.0325 0.0600 0.0600 0.0650 0.0575 0.0600 0.0450 0.0225 0.0425

#Convert table into a vector
OAS1_human_aa_freq_vector <- table_to_vector(OAS1_human_freq_table)

pander::pander(OAS1_human_aa_freq_vector)

Table continues below
A	C	D	E	F	G	H	I	K
0.0525	0.0275	0.055	0.0625	0.05	0.065	0.015	0.045	0.065

L	M	N	P	Q	R	S	T	V	W	Y
0.1075	0.01	0.0325	0.06	0.06	0.065	0.0575	0.06	0.045	0.0225	0.0425

#Check for presence of U, an unknown amino acid
# none

aa.names <- names(OAS1_human_aa_freq_vector)
any(aa.names == "U")

## [1] FALSE

#Adding my gene to the table
aa.prop$OAS1_human_aa_freq_vector <- OAS1_human_aa_freq_vector

aa.prop

##    alpha.prop   beta.prop a.plus.b.prop    a.div.b OAS1_human_aa_freq_vector
## A 0.116469146 0.073126801    0.09264161 0.08331410                    0.0525
## R 0.021659174 0.024135447    0.04129169 0.03369490                    0.0275
## N 0.039640376 0.050072046    0.06352567 0.04223402                    0.0550
## D 0.066612178 0.043587896    0.05876125 0.05631202                    0.0625
## C 0.008990601 0.027017291    0.03917417 0.01453958                    0.0500
## Q 0.027380466 0.043948127    0.03917417 0.02630972                    0.0650
## E 0.054760932 0.030979827    0.04552673 0.05931225                    0.0150
## G 0.080506743 0.106988473    0.09052409 0.08700669                    0.0450
## H 0.045361667 0.017651297    0.01746956 0.02469421                    0.0650
## I 0.037188394 0.043227666    0.04923240 0.05515809                    0.1075
## L 0.090314671 0.063760807    0.05823187 0.07823679                    0.0100
## K 0.101757254 0.041426513    0.05929063 0.07408262                    0.0325
## M 0.019615856 0.005763689    0.01323452 0.02100162                    0.0600
## F 0.050265631 0.030619597    0.02752779 0.03646434                    0.0600
## P 0.033510421 0.045749280    0.03758602 0.04338795                    0.0650
## S 0.049856968 0.122838617    0.06670196 0.07546734                    0.0575
## T 0.048630977 0.091138329    0.06193753 0.05492730                    0.0600
## W 0.013485901 0.015850144    0.01588142 0.01661666                    0.0450
## Y 0.025745811 0.039625360    0.05717311 0.03000231                    0.0225
## V 0.068246833 0.082492795    0.06511382 0.08723748                    0.0425

Functions to Calculate Similarities

# Corrleation used in Chou adn Zhange 1992.
chou_cor <- function(x,y){
  numerator <- sum(x*y)
denominator <- sqrt((sum(x^2))*(sum(y^2)))
result <- numerator/denominator
return(result)
}

# Cosine similarity used in Higgs and Attwood (2005). 
chou_cosine <- function(z.1, z.2){
  z.1.abs <- sqrt(sum(z.1^2))
  z.2.abs <- sqrt(sum(z.2^2))
  my.cosine <- sum(z.1*z.2)/(z.1.abs*z.2.abs)
  return(my.cosine)
}

#Calculate correlation between each column
corr.alpha <- chou_cor(aa.prop[,5], aa.prop[,1])
corr.beta  <- chou_cor(aa.prop[,5], aa.prop[,2])
corr.apb   <- chou_cor(aa.prop[,5], aa.prop[,3])
corr.adb   <- chou_cor(aa.prop[,5], aa.prop[,4])

#Calculate cosine similarity
cos.alpha <- chou_cosine(aa.prop[,5], aa.prop[,1])
cos.beta  <- chou_cosine(aa.prop[,5], aa.prop[,2])
cos.apb   <- chou_cosine(aa.prop[,5], aa.prop[,3])
cos.adb   <- chou_cosine(aa.prop[,5], aa.prop[,4])

#Calculate distance. #Note: we need to flip the dataframe on its side using a command called t()

aa.prop.flipped <- t(aa.prop)
round(aa.prop.flipped,2)

##                              A    R    N    D    C    Q    E    G    H    I
## alpha.prop                0.12 0.02 0.04 0.07 0.01 0.03 0.05 0.08 0.05 0.04
## beta.prop                 0.07 0.02 0.05 0.04 0.03 0.04 0.03 0.11 0.02 0.04
## a.plus.b.prop             0.09 0.04 0.06 0.06 0.04 0.04 0.05 0.09 0.02 0.05
## a.div.b                   0.08 0.03 0.04 0.06 0.01 0.03 0.06 0.09 0.02 0.06
## OAS1_human_aa_freq_vector 0.05 0.03 0.06 0.06 0.05 0.06 0.01 0.04 0.06 0.11
##                              L    K    M    F    P    S    T    W    Y    V
## alpha.prop                0.09 0.10 0.02 0.05 0.03 0.05 0.05 0.01 0.03 0.07
## beta.prop                 0.06 0.04 0.01 0.03 0.05 0.12 0.09 0.02 0.04 0.08
## a.plus.b.prop             0.06 0.06 0.01 0.03 0.04 0.07 0.06 0.02 0.06 0.07
## a.div.b                   0.08 0.07 0.02 0.04 0.04 0.08 0.05 0.02 0.03 0.09
## OAS1_human_aa_freq_vector 0.01 0.03 0.06 0.06 0.06 0.06 0.06 0.04 0.02 0.04

#We can get distance matrix like thisdist(aa.prop.flipped, method = "euclidean")
OAS1_Dist_Matrix1 <- dist(aa.prop.flipped, method = "euclidean")
OAS1_Dist_Matrix1

##                           alpha.prop  beta.prop a.plus.b.prop    a.div.b
## beta.prop                 0.13342098                                    
## a.plus.b.prop             0.09281824 0.08289406                         
## a.div.b                   0.06699039 0.08659174    0.06175113           
## OAS1_human_aa_freq_vector 0.17738526 0.16549112    0.14497565 0.15548328

#Individual distances using dist()
dist.alpha <- dist((aa.prop.flipped[c(1,5),]),  method = "euclidean")
dist.beta  <- dist((aa.prop.flipped[c(2,5),]),  method = "euclidean")
dist.apb   <- dist((aa.prop.flipped[c(3,5),]),  method = "euclidean")
dist.adb  <- dist((aa.prop.flipped[c(4,5),]), method = "euclidean")

#Compile the information. Rounding makes it easier to read
# fold types
fold.type <- c("alpha","beta","alpha plus beta", "alpha/beta")

# data
corr.sim <- round(c(corr.alpha,corr.beta,corr.apb,corr.adb),5)
cosine.sim <- round(c(cos.alpha,cos.beta,cos.apb,cos.adb),5)
Euclidean.dist <- round(c(dist.alpha,dist.beta,dist.apb,dist.adb),5)

# summary
sim.sum <- c("","","most.sim","")
dist.sum <- c("","","min.dist","")

df <- data.frame(fold.type,
           corr.sim ,
           cosine.sim ,
           Euclidean.dist ,
           sim.sum ,
           dist.sum )

#display output
pander::pander(df)

fold.type	corr.sim	cosine.sim	Euclidean.dist	sim.sum	dist.sum
alpha	0.7511	0.7511	0.1774
beta	0.7873	0.7873	0.1655
alpha plus beta	0.8221	0.8221	0.145	most.sim	min.dist
alpha/beta	0.7995	0.7995	0.1555

Percent Identity Comparisons (PID)

Data preparation

Convert all FASTA records intro entries in a single vector. FASTA entries are contained in a list produced at the beginning of the script. They were cleaned to remove the header and newline characters

# make each entry of the list into a vector
OAS1s_list_vector <- fasta_cleaner(OAS1s_list, parse = TRUE)
OAS1s_list_vector_Unlist <- unlist(OAS1s_list_vector)

# name the vector
names(OAS1s_list_vector) <- names(OAS1s_list)

OAS1s_list_vector

##                  NP_001077418.1  XP_031299144.1     NP_620268.2  NP_001025017.2 
##             "M"             "M"             "D"             "L"             "R" 
##    XP_016809250  NP_001075958.1  NP_001041596.1  XP_003952355.1      AYA44748.1 
##             "N"             "T"             "P"             "A"             "K" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "S"             "L"             "D"             "K"             "F" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "I"             "E"             "D"             "Y"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "P"             "D"             "T"             "C" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "F"             "R"             "M"             "Q"             "I" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "N"             "H"             "A"             "I"             "D" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "I"             "I"             "C"             "G"             "F" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "K"             "E"             "R"             "C" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "F"             "R"             "G"             "S"             "S" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Y"             "P"             "V"             "C"             "V" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "S"             "K"             "V"             "V"             "K" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "G"             "G"             "S"             "S"             "G" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "K"             "G"             "T"             "T"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "R"             "G"             "R"             "S"             "D" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "A"             "D"             "L"             "V"             "V" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "F"             "L"             "S"             "P"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "T"             "T"             "F"             "Q"             "D" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Q"             "L"             "N"             "R"             "R" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "G"             "E"             "F"             "I"             "Q" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "E"             "I"             "R"             "R"             "Q" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "E"             "A"             "C"             "Q" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "R"             "E"             "R"             "A"             "F" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "S"             "V"             "K"             "F"             "E" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "V"             "Q"             "A"             "P"             "R" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "W"             "G"             "N"             "P"             "R" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "A"             "L"             "S"             "F"             "V" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "S"             "S"             "L"             "Q" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "G"             "E"             "G"             "V" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "E"             "F"             "D"             "V"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "P"             "A"             "F"             "D"             "A" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "G"             "Q"             "L"             "T" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "G"             "G"             "Y"             "K"             "P" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "N"             "P"             "Q"             "I"             "Y" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "V"             "K"             "L"             "I"             "E" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "E"             "C"             "T"             "D"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Q"             "K"             "E"             "G"             "E" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "F"             "S"             "T"             "C"             "F" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "T"             "E"             "L"             "Q"             "R" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "D"             "F"             "L"             "K"             "Q" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "R"             "P"             "T"             "K"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "K"             "S"             "L"             "I"             "R" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "V"             "K"             "H"             "W" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Y"             "Q"             "N"             "C"             "K" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "K"             "K"             "L"             "G"             "K" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "P"             "P"             "Q"             "Y" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "A"             "L"             "E"             "L"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "T"             "V"             "Y"             "A"             "W" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "E"             "R"             "G"             "S"             "M" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "K"             "T"             "H"             "F"             "N" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "T"             "A"             "Q"             "G"             "F" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "R"             "T"             "V"             "L"             "E" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "V"             "I"             "N"             "Y" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Q"             "Q"             "L"             "C"             "I" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Y"             "W"             "T"             "K"             "Y" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Y"             "D"             "F"             "K"             "N" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "P"             "I"             "I"             "E"             "K" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Y"             "L"             "R"             "R"             "Q" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "T"             "K"             "P"             "R" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "P"             "V"             "I"             "L"             "D" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "P"             "A"             "D"             "P"             "T" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "G"             "N"             "L"             "G"             "G" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "G"             "D"             "P"             "K"             "G" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "W"             "R"             "Q"             "L"             "A" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "Q"             "E"             "A"             "E"             "A" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "W"             "L"             "N"             "Y"             "P" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "C"             "F"             "K"             "N"             "W" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "D"             "G"             "S"             "P"             "V" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "S"             "S"             "W"             "I"             "L" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "L"             "A"             "E"             "S"             "N" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "S"             "A"             "D"             "D"             "E" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "T"             "D"             "D"             "P"             "R" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "R"             "Y"             "Q"             "K"             "Y" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "G"             "Y"             "I"             "G"             "T" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "H"             "E"             "Y"             "P"             "H" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "F"             "S"             "H"             "R"             "P" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "S"             "T"             "L"             "Q"             "A" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "A"             "S"             "T"             "P"             "Q" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "A"             "E"             "E"             "D"             "W" 
##            <NA>            <NA>            <NA>            <NA>            <NA> 
##             "T"             "C"             "T"             "I"             "L"

PID Table

Do pairwise alignments for humans, chimps and two other species. 4 SPECIES

Humans, Chimps, Pig, Cattle

#Pairwise alignments 
Align.Human.vs.Chimp <- Biostrings:: pairwiseAlignment(HumanOAS1_string,ChimpOAS1_string)

Align.Human.vs.Pig <-Biostrings:: pairwiseAlignment(HumanOAS1_string , PigOAS1_string)

Align.Human.vs.Cattle <- Biostrings:: pairwiseAlignment(HumanOAS1_string , CattleOAS1_string)

Align.Pig.vs.Cattle <- Biostrings:: pairwiseAlignment(PigOAS1_string, CattleOAS1_string)

Align.Pig.vs.Chimp <- Biostrings:: pairwiseAlignment(PigOAS1_string, ChimpOAS1_string)

Align.Cattle.vs.Chimp <- Biostrings:: pairwiseAlignment(CattleOAS1_string, ChimpOAS1_string)

Align.Human.vs.Chimp

## Global PairwiseAlignmentsSingleSubject (1 of 1)
## pattern: MMD-LRNTPAKSLDKFIEDYLLPDTCFRMQINHA...YIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
## subject: MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSA...-----EVPVD----------------EAWSCILL
## score: 190.5778

Align.Human.vs.Pig

## Global PairwiseAlignmentsSingleSubject (1 of 1)
## pattern: MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAI...YIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
## subject: MMDLRNTPAKSLDKFIEDYLLPDKCFRKQINHAI...YIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
## score: 1576.371

Align.Human.vs.Cattle

## Global PairwiseAlignmentsSingleSubject (1 of 1)
## pattern: MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAI...YIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
## subject: MPELKDTPAKDLDRFIENYLLPDTQFRRQVKEAI...-------P----------ASSLM-----------
## score: 294.4836

Align.Pig.vs.Cattle

## Global PairwiseAlignmentsSingleSubject (1 of 1)
## pattern: MMDLRNTPAKSLDKFIEDYLLPDKCFRKQINHAI...YIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
## subject: MPELKDTPAKDLDRFIENYLLPDTQFRRQVKEAI...-------P----------ASSLM-----------
## score: 277.2125

Align.Pig.vs.Chimp

## Global PairwiseAlignmentsSingleSubject (1 of 1)
## pattern: MMD-LRNTPAKSLDKFIEDYLLPDKCFRKQINHA...YIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
## subject: MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSA...-----EVPVD----------------EAWSCILL
## score: 161.9436

Align.Cattle.vs.Chimp

## Global PairwiseAlignmentsSingleSubject (1 of 1)
## pattern: MP-ELKDTPAKDLDRFIENYLLPDTQFRRQVKEA...ARVWLSYPCFKKWDGSPVGSWDVLVKPASS--LM
## subject: MEQELRSTPSWKLDKFIEVYLLPNTSFRDDVKSA...ARLWLQYPCFMNRGGSPVSSWEVPVDEAWSCILL
## score: 304.4762

Build Matrix

pids <- c(1, NA, NA, NA, pid(Align.Human.vs.Chimp), 1, NA, NA, pid(Align.Human.vs.Pig), pid(Align.Human.vs.Cattle), 1, NA, pid(Align.Pig.vs.Cattle), pid(Align.Pig.vs.Chimp), pid(Align.Cattle.vs.Chimp), 1)

mat <- matrix(pids, nrow = 4, byrow = T)
row.names(mat) <- c("Homo","Pan","Pig","Cattle")   
colnames(mat) <- c("Homo","Pan","Pig","Cattle")   
pander::pander(mat)

	Homo	Pan	Pig	Cattle
Homo	1	NA	NA	NA
Pan	62.19	1	NA	NA
Pig	96.01	66.67	1	NA
Cattle	65.98	61.29	67.6	1

PID Methods Comparison

#C ompare different PID methods. Humans vs. chimps # using the four different methods avaialbe in R

Biostrings::pid(Align.Human.vs.Chimp, type = "PID1")

## [1] 62.18905

Biostrings::pid(Align.Human.vs.Chimp, type = "PID2")

## [1] 70.22472

Biostrings::pid(Align.Human.vs.Chimp, type = "PID3")

## [1] 69.8324

Biostrings::pid(Align.Human.vs.Chimp, type = "PID4")

## [1] 65.96306

Multiple Sequence Alignment

MSA Data Preparation

For use with R bioinformatics tools we need to convert our named vector to a string set using Biostrings::AAStringSet(). Note the _ss tag at the end of the object we’re assigning the output to, which designates this as a string set.

#Data Prep

OAS1s_Vector_StringSet <- Biostrings::AAStringSet(OAS1s_list_vector_Unlist)

Building Multiple Sequence Alignment (MSA)

ggmsa

OAS1_align <- msa(OAS1s_Vector_StringSet, method = "ClustalW")

## use default substitution matrix

## use default substitution matrix

Cleaning / Setting up an MSA

class(OAS1_align)

## [1] "MsaAAMultipleAlignment"
## attr(,"package")
## [1] "msa"

is(OAS1_align)

## [1] "MsaAAMultipleAlignment" "AAMultipleAlignment"    "MsaMetaData"           
## [4] "MultipleAlignment"

#change class of alignment
class(OAS1_align) <- "AAMultipleAlignment"

#convert to sequinr format
OAS1_align_seqinr <- msaConvert(OAS1_align, type = "seqinr::alignment")

#Print MSA
compbio4all::print_msa(OAS1_align_seqinr)

## [1] "L 59"
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## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] " "

Display Finished MSA

compbio4all::print_msa(OAS1_align_seqinr)

## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "L 59"
## [1] "M 59"
## [1] "M 59"
## [1] "M 59"
## [1] "M 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "D 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "R 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "N 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "T 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "P 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "A 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "K 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "S 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "F 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "I 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "E 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "Y 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "C 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "Q 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "H 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "G 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "V 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] "W 59"
## [1] " "

Distance Matrix

OAS1_Dist_Mat <- seqinr::dist.alignment(OAS1_align_seqinr, matrix = "identity")
is(OAS1_Dist_Mat)

## [1] "dist"     "oldClass"

class(OAS1_Dist_Mat)

## [1] "dist"

#Round for display

OAS1_Dist_Mat_Rounded <- round(OAS1_Dist_Mat, 3)
OAS1_Dist_Mat_Rounded

##     1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
## 2   0                                                                         
## 3   0 0                                                                       
## 4   0 0 0                                                                     
## 5   0 0 0 0                                                                   
## 6   0 0 0 0 0                                                                 
## 7   0 0 0 0 0 0                                                               
## 8   0 0 0 0 0 0 0                                                             
## 9   0 0 0 0 0 0 0 0                                                           
## 10  0 0 0 0 0 0 0 0 0                                                         
## 11  0 0 0 0 0 0 0 0 0  0                                                      
## 12  0 0 0 0 0 0 0 0 0  0  0                                                   
## 13  0 0 0 0 0 0 0 0 0  0  0  0                                                
## 14  0 0 0 0 0 0 0 0 0  0  0  0  0                                             
## 15  0 0 0 0 0 0 0 0 0  0  0  0  0  0                                          
## 16  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0                                       
## 17  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0                                    
## 18  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0                                 
## 19  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0                              
## 20  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0                           
## 21  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0                        
## 22  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0                     
## 23  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0                  
## 24  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0               
## 25  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0            
## 26  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0         
## 27  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0      
## 28  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0   
## 29  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 30  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 31  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 32  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 33  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 34  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 35  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 36  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 37  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 38  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 39  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 40  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 41  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 42  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 43  0 0 0 0 0 0 0 0 0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0
## 44  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 45  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 46  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 47  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 48  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 49  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 50  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 51  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 52  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 53  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 54  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 55  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 56  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 57  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 58  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 59  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 60  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 61  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 62  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 63  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 64  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 65  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 66  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 67  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 68  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 69  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 70  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 71  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 72  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 73  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 74  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 75  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 76  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 77  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 78  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 79  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 80  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 81  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 82  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 83  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 84  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 85  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 86  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 87  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 88  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 89  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 90  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 91  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 92  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 93  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 94  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 95  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 96  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 97  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 98  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 99  1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 100 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 101 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 102 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 103 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 104 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 105 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 106 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 107 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 108 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 109 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 110 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 111 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 112 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 113 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 114 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 115 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 116 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 117 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 118 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 119 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 120 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 121 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 122 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 123 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 124 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 125 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 126 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 127 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 128 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 129 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 130 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 131 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 132 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 133 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 134 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 135 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 136 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 137 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 138 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 139 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 140 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 141 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 142 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 143 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 144 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 145 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 146 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 147 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 148 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 149 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 150 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 151 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 152 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 153 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 154 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 155 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 156 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 157 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 158 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 159 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 160 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 161 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 162 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 163 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 164 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 165 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 166 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 167 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 168 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 169 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 170 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 171 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 172 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 173 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 174 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 175 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 176 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 177 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 178 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 179 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 180 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 181 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 182 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 183 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 184 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 185 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 186 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 187 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 188 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 189 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 190 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 191 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 192 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 193 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 194 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 195 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 196 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 197 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 198 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 199 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 200 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 201 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 202 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 203 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 204 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 205 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 206 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 207 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 208 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 209 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 210 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 211 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 212 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 213 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 214 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 215 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 216 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 217 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 218 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 219 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 220 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 221 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 222 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 223 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 224 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 225 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 226 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 227 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 228 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 229 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 230 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 231 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 232 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 233 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 234 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 235 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 236 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 237 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 238 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 239 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 240 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 241 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 242 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 243 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 244 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 245 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 246 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 247 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 248 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 249 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 250 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 251 1 1 1 1 1 1 1 1 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
##     29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53
## 2                                                                             
## 3                                                                             
## 4                                                                             
## 5                                                                             
## 6                                                                             
## 7                                                                             
## 8                                                                             
## 9                                                                             
## 10                                                                            
## 11                                                                            
## 12                                                                            
## 13                                                                            
## 14                                                                            
## 15                                                                            
## 16                                                                            
## 17                                                                            
## 18                                                                            
## 19                                                                            
## 20                                                                            
## 21                                                                            
## 22                                                                            
## 23                                                                            
## 24                                                                            
## 25                                                                            
## 26                                                                            
## 27                                                                            
## 28                                                                            
## 29                                                                            
## 30   0                                                                        
## 31   0  0                                                                     
## 32   0  0  0                                                                  
## 33   0  0  0  0                                                               
## 34   0  0  0  0  0                                                            
## 35   0  0  0  0  0  0                                                         
## 36   0  0  0  0  0  0  0                                                      
## 37   0  0  0  0  0  0  0  0                                                   
## 38   0  0  0  0  0  0  0  0  0                                                
## 39   0  0  0  0  0  0  0  0  0  0                                             
## 40   0  0  0  0  0  0  0  0  0  0  0                                          
## 41   0  0  0  0  0  0  0  0  0  0  0  0                                       
## 42   0  0  0  0  0  0  0  0  0  0  0  0  0                                    
## 43   0  0  0  0  0  0  0  0  0  0  0  0  0  0                                 
## 44   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1                              
## 45   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0                           
## 46   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0                        
## 47   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0                     
## 48   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1                  
## 49   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0               
## 50   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0            
## 51   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0         
## 52   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0      
## 53   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0   
## 54   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 55   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 56   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 57   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 58   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 59   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 60   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 61   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 62   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 63   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 64   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 65   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 66   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 67   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 68   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 69   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0  0  0
## 70   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 71   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 72   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 73   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 74   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 75   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 76   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 77   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 78   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 79   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 80   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 81   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 82   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 83   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 84   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 85   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 86   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 87   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 88   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 89   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 90   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 91   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 92   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 93   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 94   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 95   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 96   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 97   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 98   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 99   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 100  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 101  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 102  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 103  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 104  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 105  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 106  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 107  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 108  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 109  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 110  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 111  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 112  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 113  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 114  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 115  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 116  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 117  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 118  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 119  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 120  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 121  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 122  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 123  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 124  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 125  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 126  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 127  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 128  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 129  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 130  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 131  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 132  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 133  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 134  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 135  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 136  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 137  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 138  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 139  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 140  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 141  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 142  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 143  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 144  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 145  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 146  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 147  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 148  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
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## 189  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
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## 191  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
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## 193  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 194  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 195  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 196  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 197  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 198  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 199  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 200  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 201  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 202  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 203  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 204  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 205  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 206  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 207  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
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## 231  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
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## 233  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 234  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 235  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 236  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
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## 240  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 241  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 242  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 243  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 244  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 245  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 246  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 247  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 248  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 249  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 250  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 251  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
##     54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78
## 2                                                                             
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## 53                                                                            
## 54                                                                            
## 55   0                                                                        
## 56   0  0                                                                     
## 57   0  0  0                                                                  
## 58   0  0  0  0                                                               
## 59   0  0  0  0  0                                                            
## 60   0  0  0  0  0  0                                                         
## 61   0  0  0  0  0  0  0                                                      
## 62   0  0  0  0  0  0  0  0                                                   
## 63   0  0  0  0  0  0  0  0  0                                                
## 64   0  0  0  0  0  0  0  0  0  0                                             
## 65   0  0  0  0  0  0  0  0  0  0  0                                          
## 66   0  0  0  0  0  0  0  0  0  0  0  0                                       
## 67   0  0  0  0  0  0  0  0  0  0  0  0  0                                    
## 68   0  0  0  0  0  0  0  0  0  0  0  0  0  0                                 
## 69   0  0  0  0  0  0  0  0  0  0  0  0  0  0  0                              
## 70   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1                           
## 71   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0                        
## 72   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0                     
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## 96   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 97   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 98   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 99   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 100  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 101  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 102  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 103  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 104  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 105  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 106  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 107  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 108  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 109  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 110  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 111  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 112  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 113  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 114  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 115  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 116  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 117  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 118  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 119  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 120  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 121  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 122  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 123  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 124  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 125  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 126  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 127  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 128  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 129  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 130  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 131  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 132  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 133  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 134  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 135  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 136  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 137  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 138  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 139  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 140  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 141  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 142  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 143  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 144  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 145  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 146  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 147  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 148  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 149  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 150  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 151  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 152  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 153  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 154  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 155  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 156  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 157  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 158  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 159  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 160  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 161  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 162  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 163  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 164  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 165  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 166  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 167  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 168  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 169  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 170  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 171  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 172  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 173  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 174  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 175  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 176  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 177  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 178  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 179  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 180  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 181  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 182  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 183  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 184  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 185  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 186  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 187  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 188  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 189  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 190  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 191  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 192  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 193  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 194  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 195  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 196  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 197  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 198  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 199  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 200  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 201  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 202  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 203  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 204  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 205  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 206  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 207  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 208  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 209  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 210  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 211  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 212  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 213  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 214  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 215  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 216  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 217  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 218  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 219  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 220  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 221  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 222  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 223  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 224  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 225  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 226  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 227  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 228  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 229  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 230  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 231  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 232  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 233  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 234  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 235  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 236  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 237  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 238  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 239  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 240  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 241  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 242  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 243  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 244  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 245  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 246  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 247  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 248  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 249  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 250  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
## 251  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1
##     79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102
## 2                                                                             
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## 77                                                                            
## 78                                                                            
## 79                                                                            
## 80   0                                                                        
## 81   0  0                                                                     
## 82   0  0  0                                                                  
## 83   0  0  0  0                                                               
## 84   0  0  0  0  0                                                            
## 85   0  0  0  0  0  0                                                         
## 86   0  0  0  0  0  0  0                                                      
## 87   0  0  0  0  0  0  0  0                                                   
## 88   0  0  0  0  0  0  0  0  0                                                
## 89   0  0  0  0  0  0  0  0  0  0                                             
## 90   0  0  0  0  0  0  0  0  0  0  0                                          
## 91   0  0  0  0  0  0  0  0  0  0  0  0                                       
## 92   0  0  0  0  0  0  0  0  0  0  0  0  0                                    
## 93   0  0  0  0  0  0  0  0  0  0  0  0  0  0                                 
## 94   0  0  0  0  0  0  0  0  0  0  0  0  0  0  0                              
## 95   0  0  0  0  0  0  0  0  0  0  0  0  0  0  0  0                           
## 96   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1                        
## 97   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0                     
## 98   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0                  
## 99   1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0               
## 100  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0            
## 101  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0        
## 102  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0   0    
## 103  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0   0   0
## 104  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0   0   0
## 105  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0   0   0
## 106  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0   0   0
## 107  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0   0   0
## 108  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  0  0  0  0   0   0   0
## 109  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 110  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 111  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 112  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 113  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 114  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 115  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 116  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 117  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 118  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 119  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 120  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 121  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 122  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 123  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 124  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 125  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 126  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 127  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 128  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 129  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 130  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 131  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 132  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 133  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 134  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 135  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 136  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 137  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 138  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 139  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 140  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 141  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 142  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 143  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 144  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 145  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 146  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 147  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 148  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 149  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 150  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 151  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 152  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 153  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 154  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 155  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 156  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 157  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 158  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 159  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 160  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 161  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 162  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 163  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 164  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 165  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 166  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 167  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 168  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 169  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 170  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 171  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 172  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 173  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 174  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 175  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 176  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 177  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 178  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 179  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 180  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 181  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 182  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 183  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 184  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 185  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 186  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 187  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 188  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 189  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 190  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 191  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 192  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 193  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 194  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 195  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 196  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 197  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 198  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 199  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 200  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 201  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 202  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 203  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 204  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 205  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 206  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 207  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 208  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 209  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 210  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 211  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 212  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 213  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 214  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 215  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 216  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 217  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 218  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 219  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 220  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 221  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 222  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 223  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 224  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 225  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 226  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 227  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 228  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 229  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 230  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 231  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 232  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 233  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 234  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 235  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 236  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 237  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 238  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 239  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 240  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 241  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 242  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 243  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 244  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 245  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 246  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 247  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 248  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 249  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 250  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
## 251  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   1   1   1
##     103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121
## 2                                                                              
## 3                                                                              
## 4                                                                              
## 5                                                                              
## 6                                                                              
## 7                                                                              
## 8                                                                              
## 9                                                                              
## 10                                                                             
## 11                                                                             
## 12                                                                             
## 13                                                                             
## 14                                                                             
## 15                                                                             
## 16                                                                             
## 17                                                                             
## 18                                                                             
## 19                                                                             
## 20                                                                             
## 21                                                                             
## 22                                                                             
## 23                                                                             
## 24                                                                             
## 25                                                                             
## 26                                                                             
## 27                                                                             
## 28                                                                             
## 29                                                                             
## 30                                                                             
## 31                                                                             
## 32                                                                             
## 33                                                                             
## 34                                                                             
## 35                                                                             
## 36                                                                             
## 37                                                                             
## 38                                                                             
## 39                                                                             
## 40                                                                             
## 41                                                                             
## 42                                                                             
## 43                                                                             
## 44                                                                             
## 45                                                                             
## 46                                                                             
## 47                                                                             
## 48                                                                             
## 49                                                                             
## 50                                                                             
## 51                                                                             
## 52                                                                             
## 53                                                                             
## 54                                                                             
## 55                                                                             
## 56                                                                             
## 57                                                                             
## 58                                                                             
## 59                                                                             
## 60                                                                             
## 61                                                                             
## 62                                                                             
## 63                                                                             
## 64                                                                             
## 65                                                                             
## 66                                                                             
## 67                                                                             
## 68                                                                             
## 69                                                                             
## 70                                                                             
## 71                                                                             
## 72                                                                             
## 73                                                                             
## 74                                                                             
## 75                                                                             
## 76                                                                             
## 77                                                                             
## 78                                                                             
## 79                                                                             
## 80                                                                             
## 81                                                                             
## 82                                                                             
## 83                                                                             
## 84                                                                             
## 85                                                                             
## 86                                                                             
## 87                                                                             
## 88                                                                             
## 89                                                                             
## 90                                                                             
## 91                                                                             
## 92                                                                             
## 93                                                                             
## 94                                                                             
## 95                                                                             
## 96                                                                             
## 97                                                                             
## 98                                                                             
## 99                                                                             
## 100                                                                            
## 101                                                                            
## 102                                                                            
## 103                                                                            
## 104   0                                                                        
## 105   0   0                                                                    
## 106   0   0   0                                                                
## 107   0   0   0   0                                                            
## 108   0   0   0   0   0                                                        
## 109   1   1   1   1   1   1                                                    
## 110   1   1   1   1   1   1   0                                                
## 111   1   1   1   1   1   1   0   0                                            
## 112   1   1   1   1   1   1   0   0   0                                        
## 113   1   1   1   1   1   1   0   0   0   0                                    
## 114   1   1   1   1   1   1   0   0   0   0   0                                
## 115   1   1   1   1   1   1   0   0   0   0   0   0                            
## 116   1   1   1   1   1   1   0   0   0   0   0   0   0                        
## 117   1   1   1   1   1   1   0   0   0   0   0   0   0   0                    
## 118   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0                
## 119   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0            
## 120   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0        
## 121   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0    
## 122   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 123   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 124   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 125   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 126   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 127   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 128   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 129   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 130   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 131   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 132   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 133   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 134   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 135   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 136   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 137   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 138   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 139   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 140   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 141   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 142   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 143   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 144   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 145   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 146   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 147   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 148   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 149   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 150   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 151   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 152   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 153   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 154   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 155   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 156   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 157   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 158   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 159   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 160   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 161   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 162   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 163   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 164   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 165   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 166   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 167   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 168   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 169   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 170   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 171   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 172   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 173   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 174   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 175   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 176   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 177   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 178   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 179   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 180   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 181   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 182   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 183   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 184   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 185   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 186   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 187   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 188   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 189   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 190   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 191   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 192   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 193   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 194   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 195   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 196   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 197   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 198   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 199   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 200   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 201   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 202   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 203   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 204   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 205   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 206   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 207   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 208   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 209   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 210   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 211   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 212   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 213   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 214   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 215   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 216   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 217   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 218   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 219   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 220   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 221   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 222   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 223   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 224   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 225   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 226   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 227   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 228   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 229   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 230   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 231   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 232   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 233   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 234   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 235   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 236   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 237   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 238   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 239   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 240   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 241   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 242   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 243   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 244   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 245   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 246   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 247   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 248   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 249   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 250   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 251   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
##     122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140
## 2                                                                              
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## 47                                                                             
## 48                                                                             
## 49                                                                             
## 50                                                                             
## 51                                                                             
## 52                                                                             
## 53                                                                             
## 54                                                                             
## 55                                                                             
## 56                                                                             
## 57                                                                             
## 58                                                                             
## 59                                                                             
## 60                                                                             
## 61                                                                             
## 62                                                                             
## 63                                                                             
## 64                                                                             
## 65                                                                             
## 66                                                                             
## 67                                                                             
## 68                                                                             
## 69                                                                             
## 70                                                                             
## 71                                                                             
## 72                                                                             
## 73                                                                             
## 74                                                                             
## 75                                                                             
## 76                                                                             
## 77                                                                             
## 78                                                                             
## 79                                                                             
## 80                                                                             
## 81                                                                             
## 82                                                                             
## 83                                                                             
## 84                                                                             
## 85                                                                             
## 86                                                                             
## 87                                                                             
## 88                                                                             
## 89                                                                             
## 90                                                                             
## 91                                                                             
## 92                                                                             
## 93                                                                             
## 94                                                                             
## 95                                                                             
## 96                                                                             
## 97                                                                             
## 98                                                                             
## 99                                                                             
## 100                                                                            
## 101                                                                            
## 102                                                                            
## 103                                                                            
## 104                                                                            
## 105                                                                            
## 106                                                                            
## 107                                                                            
## 108                                                                            
## 109                                                                            
## 110                                                                            
## 111                                                                            
## 112                                                                            
## 113                                                                            
## 114                                                                            
## 115                                                                            
## 116                                                                            
## 117                                                                            
## 118                                                                            
## 119                                                                            
## 120                                                                            
## 121                                                                            
## 122                                                                            
## 123   0                                                                        
## 124   0   0                                                                    
## 125   0   0   0                                                                
## 126   0   0   0   0                                                            
## 127   0   0   0   0   0                                                        
## 128   0   0   0   0   0   0                                                    
## 129   0   0   0   0   0   0   0                                                
## 130   0   0   0   0   0   0   0   0                                            
## 131   0   0   0   0   0   0   0   0   0                                        
## 132   0   0   0   0   0   0   0   0   0   0                                    
## 133   1   1   1   1   1   1   1   1   1   1   1                                
## 134   1   1   1   1   1   1   1   1   1   1   1   0                            
## 135   1   1   1   1   1   1   1   1   1   1   1   0   0                        
## 136   1   1   1   1   1   1   1   1   1   1   1   0   0   0                    
## 137   1   1   1   1   1   1   1   1   1   1   1   0   0   0   0                
## 138   1   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0            
## 139   1   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0        
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## 159   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
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## 161   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 162   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 163   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 164   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 165   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 166   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 167   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 168   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 169   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 170   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 171   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 172   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 173   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 174   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 175   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 176   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 177   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 178   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 179   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 180   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 181   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 182   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 183   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 184   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 185   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 186   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 187   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 188   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 189   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 190   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 191   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 192   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 193   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 194   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 195   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 196   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 197   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 198   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 199   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 200   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 201   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 202   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 203   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 204   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 205   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 206   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 207   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 208   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 209   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 210   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 211   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 212   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 213   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 214   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 215   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 216   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 217   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 218   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 219   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 220   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 221   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 222   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 223   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 224   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 225   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 226   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 227   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 228   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 229   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 230   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 231   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 232   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 233   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 234   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 235   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 236   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 237   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 238   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 239   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 240   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 241   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 242   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 243   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 244   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 245   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 246   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 247   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 248   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 249   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 250   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 251   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
##     141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159
## 2                                                                              
## 3                                                                              
## 4                                                                              
## 5                                                                              
## 6                                                                              
## 7                                                                              
## 8                                                                              
## 9                                                                              
## 10                                                                             
## 11                                                                             
## 12                                                                             
## 13                                                                             
## 14                                                                             
## 15                                                                             
## 16                                                                             
## 17                                                                             
## 18                                                                             
## 19                                                                             
## 20                                                                             
## 21                                                                             
## 22                                                                             
## 23                                                                             
## 24                                                                             
## 25                                                                             
## 26                                                                             
## 27                                                                             
## 28                                                                             
## 29                                                                             
## 30                                                                             
## 31                                                                             
## 32                                                                             
## 33                                                                             
## 34                                                                             
## 35                                                                             
## 36                                                                             
## 37                                                                             
## 38                                                                             
## 39                                                                             
## 40                                                                             
## 41                                                                             
## 42                                                                             
## 43                                                                             
## 44                                                                             
## 45                                                                             
## 46                                                                             
## 47                                                                             
## 48                                                                             
## 49                                                                             
## 50                                                                             
## 51                                                                             
## 52                                                                             
## 53                                                                             
## 54                                                                             
## 55                                                                             
## 56                                                                             
## 57                                                                             
## 58                                                                             
## 59                                                                             
## 60                                                                             
## 61                                                                             
## 62                                                                             
## 63                                                                             
## 64                                                                             
## 65                                                                             
## 66                                                                             
## 67                                                                             
## 68                                                                             
## 69                                                                             
## 70                                                                             
## 71                                                                             
## 72                                                                             
## 73                                                                             
## 74                                                                             
## 75                                                                             
## 76                                                                             
## 77                                                                             
## 78                                                                             
## 79                                                                             
## 80                                                                             
## 81                                                                             
## 82                                                                             
## 83                                                                             
## 84                                                                             
## 85                                                                             
## 86                                                                             
## 87                                                                             
## 88                                                                             
## 89                                                                             
## 90                                                                             
## 91                                                                             
## 92                                                                             
## 93                                                                             
## 94                                                                             
## 95                                                                             
## 96                                                                             
## 97                                                                             
## 98                                                                             
## 99                                                                             
## 100                                                                            
## 101                                                                            
## 102                                                                            
## 103                                                                            
## 104                                                                            
## 105                                                                            
## 106                                                                            
## 107                                                                            
## 108                                                                            
## 109                                                                            
## 110                                                                            
## 111                                                                            
## 112                                                                            
## 113                                                                            
## 114                                                                            
## 115                                                                            
## 116                                                                            
## 117                                                                            
## 118                                                                            
## 119                                                                            
## 120                                                                            
## 121                                                                            
## 122                                                                            
## 123                                                                            
## 124                                                                            
## 125                                                                            
## 126                                                                            
## 127                                                                            
## 128                                                                            
## 129                                                                            
## 130                                                                            
## 131                                                                            
## 132                                                                            
## 133                                                                            
## 134                                                                            
## 135                                                                            
## 136                                                                            
## 137                                                                            
## 138                                                                            
## 139                                                                            
## 140                                                                            
## 141                                                                            
## 142   0                                                                        
## 143   0   0                                                                    
## 144   0   0   0                                                                
## 145   0   0   0   0                                                            
## 146   0   0   0   0   0                                                        
## 147   0   0   0   0   0   0                                                    
## 148   0   0   0   0   0   0   0                                                
## 149   0   0   0   0   0   0   0   0                                            
## 150   0   0   0   0   0   0   0   0   0                                        
## 151   0   0   0   0   0   0   0   0   0   0                                    
## 152   0   0   0   0   0   0   0   0   0   0   0                                
## 153   0   0   0   0   0   0   0   0   0   0   0   0                            
## 154   0   0   0   0   0   0   0   0   0   0   0   0   0                        
## 155   0   0   0   0   0   0   0   0   0   0   0   0   0   0                    
## 156   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0                
## 157   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1            
## 158   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0        
## 159   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0    
## 160   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 161   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 162   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 163   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 164   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 165   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 166   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 167   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 168   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 169   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 170   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 171   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 172   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 173   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 174   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 175   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 176   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 177   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0   0   0
## 178   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 179   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 180   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 181   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 182   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 183   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 184   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 185   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 186   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 187   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 188   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 189   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 190   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 191   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 192   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 193   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 194   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 195   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 196   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 197   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 198   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 199   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 200   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 201   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 202   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 203   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 204   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 205   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 206   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 207   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 208   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 209   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 210   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 211   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 212   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 213   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 214   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 215   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 216   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 217   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 218   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 219   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 220   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 221   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 222   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 223   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 224   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 225   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 226   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 227   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 228   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 229   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 230   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 231   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 232   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 233   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 234   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 235   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 236   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 237   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 238   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 239   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 240   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 241   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 242   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 243   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 244   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 245   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 246   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 247   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 248   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 249   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 250   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 251   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
##     160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178
## 2                                                                              
## 3                                                                              
## 4                                                                              
## 5                                                                              
## 6                                                                              
## 7                                                                              
## 8                                                                              
## 9                                                                              
## 10                                                                             
## 11                                                                             
## 12                                                                             
## 13                                                                             
## 14                                                                             
## 15                                                                             
## 16                                                                             
## 17                                                                             
## 18                                                                             
## 19                                                                             
## 20                                                                             
## 21                                                                             
## 22                                                                             
## 23                                                                             
## 24                                                                             
## 25                                                                             
## 26                                                                             
## 27                                                                             
## 28                                                                             
## 29                                                                             
## 30                                                                             
## 31                                                                             
## 32                                                                             
## 33                                                                             
## 34                                                                             
## 35                                                                             
## 36                                                                             
## 37                                                                             
## 38                                                                             
## 39                                                                             
## 40                                                                             
## 41                                                                             
## 42                                                                             
## 43                                                                             
## 44                                                                             
## 45                                                                             
## 46                                                                             
## 47                                                                             
## 48                                                                             
## 49                                                                             
## 50                                                                             
## 51                                                                             
## 52                                                                             
## 53                                                                             
## 54                                                                             
## 55                                                                             
## 56                                                                             
## 57                                                                             
## 58                                                                             
## 59                                                                             
## 60                                                                             
## 61                                                                             
## 62                                                                             
## 63                                                                             
## 64                                                                             
## 65                                                                             
## 66                                                                             
## 67                                                                             
## 68                                                                             
## 69                                                                             
## 70                                                                             
## 71                                                                             
## 72                                                                             
## 73                                                                             
## 74                                                                             
## 75                                                                             
## 76                                                                             
## 77                                                                             
## 78                                                                             
## 79                                                                             
## 80                                                                             
## 81                                                                             
## 82                                                                             
## 83                                                                             
## 84                                                                             
## 85                                                                             
## 86                                                                             
## 87                                                                             
## 88                                                                             
## 89                                                                             
## 90                                                                             
## 91                                                                             
## 92                                                                             
## 93                                                                             
## 94                                                                             
## 95                                                                             
## 96                                                                             
## 97                                                                             
## 98                                                                             
## 99                                                                             
## 100                                                                            
## 101                                                                            
## 102                                                                            
## 103                                                                            
## 104                                                                            
## 105                                                                            
## 106                                                                            
## 107                                                                            
## 108                                                                            
## 109                                                                            
## 110                                                                            
## 111                                                                            
## 112                                                                            
## 113                                                                            
## 114                                                                            
## 115                                                                            
## 116                                                                            
## 117                                                                            
## 118                                                                            
## 119                                                                            
## 120                                                                            
## 121                                                                            
## 122                                                                            
## 123                                                                            
## 124                                                                            
## 125                                                                            
## 126                                                                            
## 127                                                                            
## 128                                                                            
## 129                                                                            
## 130                                                                            
## 131                                                                            
## 132                                                                            
## 133                                                                            
## 134                                                                            
## 135                                                                            
## 136                                                                            
## 137                                                                            
## 138                                                                            
## 139                                                                            
## 140                                                                            
## 141                                                                            
## 142                                                                            
## 143                                                                            
## 144                                                                            
## 145                                                                            
## 146                                                                            
## 147                                                                            
## 148                                                                            
## 149                                                                            
## 150                                                                            
## 151                                                                            
## 152                                                                            
## 153                                                                            
## 154                                                                            
## 155                                                                            
## 156                                                                            
## 157                                                                            
## 158                                                                            
## 159                                                                            
## 160                                                                            
## 161   0                                                                        
## 162   0   0                                                                    
## 163   0   0   0                                                                
## 164   0   0   0   0                                                            
## 165   0   0   0   0   0                                                        
## 166   0   0   0   0   0   0                                                    
## 167   0   0   0   0   0   0   0                                                
## 168   0   0   0   0   0   0   0   0                                            
## 169   0   0   0   0   0   0   0   0   0                                        
## 170   0   0   0   0   0   0   0   0   0   0                                    
## 171   0   0   0   0   0   0   0   0   0   0   0                                
## 172   0   0   0   0   0   0   0   0   0   0   0   0                            
## 173   0   0   0   0   0   0   0   0   0   0   0   0   0                        
## 174   0   0   0   0   0   0   0   0   0   0   0   0   0   0                    
## 175   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0                
## 176   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0            
## 177   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0        
## 178   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1    
## 179   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 180   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 181   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 182   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 183   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 184   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 185   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 186   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 187   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 188   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 189   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 190   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 191   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 192   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 193   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 194   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 195   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 196   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 197   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 198   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 199   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 200   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 201   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 202   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 203   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   0
## 204   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 205   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 206   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 207   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 208   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 209   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 210   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 211   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 212   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 213   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 214   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 215   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 216   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 217   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 218   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 219   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 220   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 221   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 222   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 223   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 224   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 225   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 226   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 227   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 228   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 229   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 230   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 231   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 232   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 233   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 234   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 235   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 236   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 237   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 238   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 239   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 240   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 241   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 242   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 243   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 244   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 245   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 246   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 247   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 248   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 249   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 250   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 251   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
##     179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197
## 2                                                                              
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## 31                                                                             
## 32                                                                             
## 33                                                                             
## 34                                                                             
## 35                                                                             
## 36                                                                             
## 37                                                                             
## 38                                                                             
## 39                                                                             
## 40                                                                             
## 41                                                                             
## 42                                                                             
## 43                                                                             
## 44                                                                             
## 45                                                                             
## 46                                                                             
## 47                                                                             
## 48                                                                             
## 49                                                                             
## 50                                                                             
## 51                                                                             
## 52                                                                             
## 53                                                                             
## 54                                                                             
## 55                                                                             
## 56                                                                             
## 57                                                                             
## 58                                                                             
## 59                                                                             
## 60                                                                             
## 61                                                                             
## 62                                                                             
## 63                                                                             
## 64                                                                             
## 65                                                                             
## 66                                                                             
## 67                                                                             
## 68                                                                             
## 69                                                                             
## 70                                                                             
## 71                                                                             
## 72                                                                             
## 73                                                                             
## 74                                                                             
## 75                                                                             
## 76                                                                             
## 77                                                                             
## 78                                                                             
## 79                                                                             
## 80                                                                             
## 81                                                                             
## 82                                                                             
## 83                                                                             
## 84                                                                             
## 85                                                                             
## 86                                                                             
## 87                                                                             
## 88                                                                             
## 89                                                                             
## 90                                                                             
## 91                                                                             
## 92                                                                             
## 93                                                                             
## 94                                                                             
## 95                                                                             
## 96                                                                             
## 97                                                                             
## 98                                                                             
## 99                                                                             
## 100                                                                            
## 101                                                                            
## 102                                                                            
## 103                                                                            
## 104                                                                            
## 105                                                                            
## 106                                                                            
## 107                                                                            
## 108                                                                            
## 109                                                                            
## 110                                                                            
## 111                                                                            
## 112                                                                            
## 113                                                                            
## 114                                                                            
## 115                                                                            
## 116                                                                            
## 117                                                                            
## 118                                                                            
## 119                                                                            
## 120                                                                            
## 121                                                                            
## 122                                                                            
## 123                                                                            
## 124                                                                            
## 125                                                                            
## 126                                                                            
## 127                                                                            
## 128                                                                            
## 129                                                                            
## 130                                                                            
## 131                                                                            
## 132                                                                            
## 133                                                                            
## 134                                                                            
## 135                                                                            
## 136                                                                            
## 137                                                                            
## 138                                                                            
## 139                                                                            
## 140                                                                            
## 141                                                                            
## 142                                                                            
## 143                                                                            
## 144                                                                            
## 145                                                                            
## 146                                                                            
## 147                                                                            
## 148                                                                            
## 149                                                                            
## 150                                                                            
## 151                                                                            
## 152                                                                            
## 153                                                                            
## 154                                                                            
## 155                                                                            
## 156                                                                            
## 157                                                                            
## 158                                                                            
## 159                                                                            
## 160                                                                            
## 161                                                                            
## 162                                                                            
## 163                                                                            
## 164                                                                            
## 165                                                                            
## 166                                                                            
## 167                                                                            
## 168                                                                            
## 169                                                                            
## 170                                                                            
## 171                                                                            
## 172                                                                            
## 173                                                                            
## 174                                                                            
## 175                                                                            
## 176                                                                            
## 177                                                                            
## 178                                                                            
## 179                                                                            
## 180   0                                                                        
## 181   0   0                                                                    
## 182   0   0   0                                                                
## 183   0   0   0   0                                                            
## 184   0   0   0   0   0                                                        
## 185   0   0   0   0   0   0                                                    
## 186   0   0   0   0   0   0   0                                                
## 187   0   0   0   0   0   0   0   0                                            
## 188   0   0   0   0   0   0   0   0   0                                        
## 189   0   0   0   0   0   0   0   0   0   0                                    
## 190   0   0   0   0   0   0   0   0   0   0   0                                
## 191   0   0   0   0   0   0   0   0   0   0   0   0                            
## 192   0   0   0   0   0   0   0   0   0   0   0   0   0                        
## 193   0   0   0   0   0   0   0   0   0   0   0   0   0   0                    
## 194   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0                
## 195   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0            
## 196   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0        
## 197   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0    
## 198   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0
## 199   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0
## 200   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0
## 201   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0
## 202   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0
## 203   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0   0
## 204   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 205   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 206   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 207   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 208   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 209   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 210   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 211   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 212   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 213   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 214   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 215   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 216   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 217   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 218   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 219   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 220   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 221   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 222   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 223   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 224   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 225   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 226   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 227   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 228   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 229   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 230   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 231   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 232   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 233   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 234   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 235   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 236   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 237   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 238   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 239   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 240   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 241   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 242   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 243   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 244   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 245   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 246   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 247   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 248   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 249   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 250   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 251   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
##     198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216
## 2                                                                              
## 3                                                                              
## 4                                                                              
## 5                                                                              
## 6                                                                              
## 7                                                                              
## 8                                                                              
## 9                                                                              
## 10                                                                             
## 11                                                                             
## 12                                                                             
## 13                                                                             
## 14                                                                             
## 15                                                                             
## 16                                                                             
## 17                                                                             
## 18                                                                             
## 19                                                                             
## 20                                                                             
## 21                                                                             
## 22                                                                             
## 23                                                                             
## 24                                                                             
## 25                                                                             
## 26                                                                             
## 27                                                                             
## 28                                                                             
## 29                                                                             
## 30                                                                             
## 31                                                                             
## 32                                                                             
## 33                                                                             
## 34                                                                             
## 35                                                                             
## 36                                                                             
## 37                                                                             
## 38                                                                             
## 39                                                                             
## 40                                                                             
## 41                                                                             
## 42                                                                             
## 43                                                                             
## 44                                                                             
## 45                                                                             
## 46                                                                             
## 47                                                                             
## 48                                                                             
## 49                                                                             
## 50                                                                             
## 51                                                                             
## 52                                                                             
## 53                                                                             
## 54                                                                             
## 55                                                                             
## 56                                                                             
## 57                                                                             
## 58                                                                             
## 59                                                                             
## 60                                                                             
## 61                                                                             
## 62                                                                             
## 63                                                                             
## 64                                                                             
## 65                                                                             
## 66                                                                             
## 67                                                                             
## 68                                                                             
## 69                                                                             
## 70                                                                             
## 71                                                                             
## 72                                                                             
## 73                                                                             
## 74                                                                             
## 75                                                                             
## 76                                                                             
## 77                                                                             
## 78                                                                             
## 79                                                                             
## 80                                                                             
## 81                                                                             
## 82                                                                             
## 83                                                                             
## 84                                                                             
## 85                                                                             
## 86                                                                             
## 87                                                                             
## 88                                                                             
## 89                                                                             
## 90                                                                             
## 91                                                                             
## 92                                                                             
## 93                                                                             
## 94                                                                             
## 95                                                                             
## 96                                                                             
## 97                                                                             
## 98                                                                             
## 99                                                                             
## 100                                                                            
## 101                                                                            
## 102                                                                            
## 103                                                                            
## 104                                                                            
## 105                                                                            
## 106                                                                            
## 107                                                                            
## 108                                                                            
## 109                                                                            
## 110                                                                            
## 111                                                                            
## 112                                                                            
## 113                                                                            
## 114                                                                            
## 115                                                                            
## 116                                                                            
## 117                                                                            
## 118                                                                            
## 119                                                                            
## 120                                                                            
## 121                                                                            
## 122                                                                            
## 123                                                                            
## 124                                                                            
## 125                                                                            
## 126                                                                            
## 127                                                                            
## 128                                                                            
## 129                                                                            
## 130                                                                            
## 131                                                                            
## 132                                                                            
## 133                                                                            
## 134                                                                            
## 135                                                                            
## 136                                                                            
## 137                                                                            
## 138                                                                            
## 139                                                                            
## 140                                                                            
## 141                                                                            
## 142                                                                            
## 143                                                                            
## 144                                                                            
## 145                                                                            
## 146                                                                            
## 147                                                                            
## 148                                                                            
## 149                                                                            
## 150                                                                            
## 151                                                                            
## 152                                                                            
## 153                                                                            
## 154                                                                            
## 155                                                                            
## 156                                                                            
## 157                                                                            
## 158                                                                            
## 159                                                                            
## 160                                                                            
## 161                                                                            
## 162                                                                            
## 163                                                                            
## 164                                                                            
## 165                                                                            
## 166                                                                            
## 167                                                                            
## 168                                                                            
## 169                                                                            
## 170                                                                            
## 171                                                                            
## 172                                                                            
## 173                                                                            
## 174                                                                            
## 175                                                                            
## 176                                                                            
## 177                                                                            
## 178                                                                            
## 179                                                                            
## 180                                                                            
## 181                                                                            
## 182                                                                            
## 183                                                                            
## 184                                                                            
## 185                                                                            
## 186                                                                            
## 187                                                                            
## 188                                                                            
## 189                                                                            
## 190                                                                            
## 191                                                                            
## 192                                                                            
## 193                                                                            
## 194                                                                            
## 195                                                                            
## 196                                                                            
## 197                                                                            
## 198                                                                            
## 199   0                                                                        
## 200   0   0                                                                    
## 201   0   0   0                                                                
## 202   0   0   0   0                                                            
## 203   0   0   0   0   0                                                        
## 204   1   1   1   1   1   1                                                    
## 205   1   1   1   1   1   1   0                                                
## 206   1   1   1   1   1   1   0   0                                            
## 207   1   1   1   1   1   1   0   0   0                                        
## 208   1   1   1   1   1   1   0   0   0   0                                    
## 209   1   1   1   1   1   1   0   0   0   0   0                                
## 210   1   1   1   1   1   1   0   0   0   0   0   0                            
## 211   1   1   1   1   1   1   0   0   0   0   0   0   0                        
## 212   1   1   1   1   1   1   0   0   0   0   0   0   0   0                    
## 213   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0                
## 214   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0            
## 215   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0        
## 216   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0    
## 217   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 218   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 219   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 220   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 221   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 222   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 223   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 224   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 225   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 226   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0   0   0   0   0
## 227   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 228   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 229   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 230   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 231   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 232   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 233   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 234   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 235   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 236   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 237   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 238   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 239   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 240   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 241   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 242   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 243   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 244   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 245   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 246   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 247   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 248   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 249   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 250   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 251   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
##     217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235
## 2                                                                              
## 3                                                                              
## 4                                                                              
## 5                                                                              
## 6                                                                              
## 7                                                                              
## 8                                                                              
## 9                                                                              
## 10                                                                             
## 11                                                                             
## 12                                                                             
## 13                                                                             
## 14                                                                             
## 15                                                                             
## 16                                                                             
## 17                                                                             
## 18                                                                             
## 19                                                                             
## 20                                                                             
## 21                                                                             
## 22                                                                             
## 23                                                                             
## 24                                                                             
## 25                                                                             
## 26                                                                             
## 27                                                                             
## 28                                                                             
## 29                                                                             
## 30                                                                             
## 31                                                                             
## 32                                                                             
## 33                                                                             
## 34                                                                             
## 35                                                                             
## 36                                                                             
## 37                                                                             
## 38                                                                             
## 39                                                                             
## 40                                                                             
## 41                                                                             
## 42                                                                             
## 43                                                                             
## 44                                                                             
## 45                                                                             
## 46                                                                             
## 47                                                                             
## 48                                                                             
## 49                                                                             
## 50                                                                             
## 51                                                                             
## 52                                                                             
## 53                                                                             
## 54                                                                             
## 55                                                                             
## 56                                                                             
## 57                                                                             
## 58                                                                             
## 59                                                                             
## 60                                                                             
## 61                                                                             
## 62                                                                             
## 63                                                                             
## 64                                                                             
## 65                                                                             
## 66                                                                             
## 67                                                                             
## 68                                                                             
## 69                                                                             
## 70                                                                             
## 71                                                                             
## 72                                                                             
## 73                                                                             
## 74                                                                             
## 75                                                                             
## 76                                                                             
## 77                                                                             
## 78                                                                             
## 79                                                                             
## 80                                                                             
## 81                                                                             
## 82                                                                             
## 83                                                                             
## 84                                                                             
## 85                                                                             
## 86                                                                             
## 87                                                                             
## 88                                                                             
## 89                                                                             
## 90                                                                             
## 91                                                                             
## 92                                                                             
## 93                                                                             
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## 100                                                                            
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## 215                                                                            
## 216                                                                            
## 217                                                                            
## 218   0                                                                        
## 219   0   0                                                                    
## 220   0   0   0                                                                
## 221   0   0   0   0                                                            
## 222   0   0   0   0   0                                                        
## 223   0   0   0   0   0   0                                                    
## 224   0   0   0   0   0   0   0                                                
## 225   0   0   0   0   0   0   0   0                                            
## 226   0   0   0   0   0   0   0   0   0                                        
## 227   1   1   1   1   1   1   1   1   1   1                                    
## 228   1   1   1   1   1   1   1   1   1   1   0                                
## 229   1   1   1   1   1   1   1   1   1   1   0   0                            
## 230   1   1   1   1   1   1   1   1   1   1   0   0   0                        
## 231   1   1   1   1   1   1   1   1   1   1   0   0   0   0                    
## 232   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0                
## 233   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0            
## 234   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0        
## 235   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0    
## 236   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 237   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 238   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 239   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 240   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 241   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 242   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 243   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 244   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 245   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 246   1   1   1   1   1   1   1   1   1   1   0   0   0   0   0   0   0   0   0
## 247   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 248   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 249   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 250   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
## 251   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1   1
##     236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254
## 2                                                                              
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## 236                                                                            
## 237   0                                                                        
## 238   0   0                                                                    
## 239   0   0   0                                                                
## 240   0   0   0   0                                                            
## 241   0   0   0   0   0                                                        
## 242   0   0   0   0   0   0                                                    
## 243   0   0   0   0   0   0   0                                                
## 244   0   0   0   0   0   0   0   0                                            
## 245   0   0   0   0   0   0   0   0   0                                        
## 246   0   0   0   0   0   0   0   0   0   0                                    
## 247   1   1   1   1   1   1   1   1   1   1   1                                
## 248   1   1   1   1   1   1   1   1   1   1   1   0                            
## 249   1   1   1   1   1   1   1   1   1   1   1   0   0                        
## 250   1   1   1   1   1   1   1   1   1   1   1   0   0   0                    
## 251   1   1   1   1   1   1   1   1   1   1   1   0   0   0   0                
##     255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273
## 2                                                                              
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##     274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292
## 2                                                                              
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##  [ reached getOption("max.print") -- omitted 149 rows ]

Phylognetic Trees of Sequences

Build a phylogenetic tree from distance matrix

#build a phylogeentic tre from the distance matrix
OAS1_Tree <- nj(OAS1_Dist_Mat)

Phylogenetic Tree for All Sequences

#Plot the tree
OAS1_Plotted_Tree <- plot.phylo(OAS1_Tree, main = "Phylogenetic Tree", type = "phylogram", use.edge.length = FALSE)

#add label
mtext (text = "OAS1 family gene tree - rooted with no branch lengths" )

CB Final Portfolio

Jared Harris

12/14/2021