Description

summary(Limouse)
##     patients  étio.emphysème Lobe.A.choisi lobe_B_choisi nbre_.valve_1  
##  Min.   :1   Def A1AT:1      LID  :2       LID  :3       Min.   :4.000  
##  1st Qu.:3   Tabac   :8      LIG  :3       LIG  :2       1st Qu.:5.000  
##  Median :5                   LSD  :2       LSDLM:1       Median :6.000  
##  Mean   :5                   LSDLM:1       LSG  :3       Mean   :6.222  
##  3rd Qu.:7                   LSG  :1                     3rd Qu.:7.000  
##  Max.   :9                                               Max.   :9.000  
##                                                                         
##   nbre_valve_2   volume_lobe_T._0A volume_lobe.T_.2A d_volume_Lobe_A
##  Min.   :4.000   Min.   : 954      Min.   :   0.0    Min.   :-2213  
##  1st Qu.:5.000   1st Qu.:1209      1st Qu.:   0.0    1st Qu.:-1532  
##  Median :6.000   Median :1544      Median : 804.0    Median : -930  
##  Mean   :5.889   Mean   :1685      Mean   : 620.3    Mean   :-1065  
##  3rd Qu.:6.000   3rd Qu.:1910      3rd Qu.: 850.0    3rd Qu.: -405  
##  Max.   :8.000   Max.   :3075      Max.   :1543.0    Max.   : -261  
##                                                                     
##  volume._lobe_T._0B volum_.lobe_T._.2B d_volume_Lobe_B P_perf_lobe_T_A 
##  Min.   : 924       Min.   :  0.0      Min.   :-1987   Min.   : 0.200  
##  1st Qu.:1222       1st Qu.: 50.0      1st Qu.:-1590   1st Qu.: 6.000  
##  Median :1350       Median :200.0      Median :-1152   Median : 9.000  
##  Mean   :1476       Mean   :318.3      Mean   :-1158   Mean   : 8.022  
##  3rd Qu.:1640       3rd Qu.:585.0      3rd Qu.: -704   3rd Qu.:10.000  
##  Max.   :2187       Max.   :799.0      Max.   : -339   Max.   :15.000  
##                                                                        
##  P_perf_lobe_T_B      MMRC_0          MMRC_1          MMRC_2     d1_MMRC  
##  Min.   : 0.400   Min.   :3.000   Min.   :2.000   Min.   :1   Min.   :-2  
##  1st Qu.: 5.500   1st Qu.:3.000   1st Qu.:2.000   1st Qu.:2   1st Qu.:-1  
##  Median : 8.100   Median :3.000   Median :2.000   Median :2   Median :-1  
##  Mean   : 7.357   Mean   :3.222   Mean   :2.222   Mean   :2   Mean   :-1  
##  3rd Qu.:10.500   3rd Qu.:3.000   3rd Qu.:2.000   3rd Qu.:2   3rd Qu.:-1  
##  Max.   :11.000   Max.   :4.000   Max.   :3.000   Max.   :3   Max.   : 0  
##  NA's   :2                                                                
##     d2_MMRC           d3_MMRC           BODE_0      BODE_1          BODE_2     
##  Min.   :-1.0000   Min.   :-2.000   Min.   :3   Min.   :2.000   Min.   :2.000  
##  1st Qu.:-1.0000   1st Qu.:-2.000   1st Qu.:4   1st Qu.:4.000   1st Qu.:2.000  
##  Median : 0.0000   Median :-1.000   Median :7   Median :4.000   Median :2.000  
##  Mean   :-0.2222   Mean   :-1.222   Mean   :6   Mean   :4.333   Mean   :2.889  
##  3rd Qu.: 0.0000   3rd Qu.:-1.000   3rd Qu.:7   3rd Qu.:5.000   3rd Qu.:4.000  
##  Max.   : 1.0000   Max.   : 0.000   Max.   :9   Max.   :7.000   Max.   :5.000  
##                                                                                
##     d1_BODE          d2_BODE          d3_BODE         VEMS_ml_0     
##  Min.   :-5.000   Min.   :-3.000   Min.   :-7.000   Min.   : 460.0  
##  1st Qu.:-2.000   1st Qu.:-2.000   1st Qu.:-5.000   1st Qu.: 650.0  
##  Median :-1.000   Median :-2.000   Median :-3.000   Median : 860.0  
##  Mean   :-1.667   Mean   :-1.444   Mean   :-3.111   Mean   : 918.9  
##  3rd Qu.:-1.000   3rd Qu.:-1.000   3rd Qu.:-1.000   3rd Qu.:1000.0  
##  Max.   : 0.000   Max.   : 0.000   Max.   :-1.000   Max.   :1620.0  
##                                                                     
##    VEMS_ml_1      VEMS_ml_2      d1_VEMS_ml      d2_VEMS_ml       d3_VEMS_ml   
##  Min.   : 630   Min.   : 850   Min.   : 90.0   Min.   :-160.0   Min.   :200.0  
##  1st Qu.: 800   1st Qu.:1400   1st Qu.:110.0   1st Qu.: 110.0   1st Qu.:370.0  
##  Median :1070   Median :1500   Median :230.0   Median : 250.0   Median :500.0  
##  Mean   :1204   Mean   :1448   Mean   :285.6   Mean   : 243.3   Mean   :528.9  
##  3rd Qu.:1590   3rd Qu.:1550   3rd Qu.:340.0   3rd Qu.: 400.0   3rd Qu.:600.0  
##  Max.   :2000   Max.   :2070   Max.   :690.0   Max.   : 600.0   Max.   :940.0  
##                                                                                
##    VEMS._._0       VEMS_.._1       VEMS_.._2    d1_VEMS_.       d2_VEMS_.    
##  Min.   :17.00   Min.   :29.00   Min.   :40   Min.   : 4.00   Min.   :-5.00  
##  1st Qu.:30.00   1st Qu.:34.00   1st Qu.:48   1st Qu.: 6.00   1st Qu.: 7.00  
##  Median :30.00   Median :47.00   Median :59   Median :10.00   Median :13.00  
##  Mean   :34.98   Mean   :45.33   Mean   :57   Mean   :10.36   Mean   :11.67  
##  3rd Qu.:42.00   3rd Qu.:53.00   3rd Qu.:60   3rd Qu.:12.00   3rd Qu.:19.00  
##  Max.   :58.00   Max.   :66.00   Max.   :75   Max.   :22.00   Max.   :21.00  
##                                                                              
##    d3_VEMS_.        VR_ml_0        VR_ml._1       VR_ml_2        d1_VR_ml    
##  Min.   :10.00   Min.   :4300   Min.   :3780   Min.   :3000   Min.   :-3120  
##  1st Qu.:15.00   1st Qu.:4740   1st Qu.:4028   1st Qu.:3330   1st Qu.:-1300  
##  Median :21.00   Median :5140   Median :4470   Median :3730   Median : -580  
##  Mean   :22.02   Mean   :5511   Mean   :4490   Mean   :3831   Mean   :-1021  
##  3rd Qu.:30.00   3rd Qu.:5300   3rd Qu.:4550   3rd Qu.:4083   3rd Qu.: -520  
##  Max.   :33.00   Max.   :7840   Max.   :6310   Max.   :4840   Max.   : -100  
##                                                                              
##     d2_VR_ml          d3_VR_ml         VR_._0         VR_.._1     
##  Min.   :-1470.0   Min.   :-3740   Min.   :194.0   Min.   :167.0  
##  1st Qu.:-1000.0   1st Qu.:-2300   1st Qu.:219.0   1st Qu.:180.0  
##  Median : -740.0   Median :-1270   Median :231.0   Median :193.0  
##  Mean   : -658.9   Mean   :-1680   Mean   :248.1   Mean   :204.8  
##  3rd Qu.: -527.0   3rd Qu.:-1077   3rd Qu.:255.0   3rd Qu.:235.0  
##  Max.   :  642.0   Max.   : -470   Max.   :342.0   Max.   :275.0  
##                                                                   
##     VR_.._2         d1_._VR           d2_._VR          d3_._VR       
##  Min.   :130.0   Min.   :-128.00   Min.   :-86.00   Min.   :-155.00  
##  1st Qu.:155.0   1st Qu.: -52.00   1st Qu.:-41.00   1st Qu.: -89.00  
##  Median :169.0   Median : -29.00   Median :-37.00   Median : -68.00  
##  Mean   :170.7   Mean   : -43.33   Mean   :-34.11   Mean   : -77.44  
##  3rd Qu.:189.0   3rd Qu.: -20.00   3rd Qu.:-20.00   3rd Qu.: -40.00  
##  Max.   :208.0   Max.   : -10.00   Max.   : 15.00   Max.   : -23.00  
##                                                                      
##     TLCO._0          TLCO_2         d_TLCO      dist_parc_0     dist_parc_1   
##  Min.   :19.00   Min.   :19.0   Min.   :-1.0   Min.   :105.0   Min.   :220.0  
##  1st Qu.:21.50   1st Qu.:29.0   1st Qu.: 0.0   1st Qu.:225.0   1st Qu.:298.8  
##  Median :31.50   Median :32.0   Median : 4.0   Median :300.0   Median :395.0  
##  Mean   :32.12   Mean   :36.2   Mean   : 5.2   Mean   :338.3   Mean   :401.6  
##  3rd Qu.:42.00   3rd Qu.:40.0   3rd Qu.: 9.0   3rd Qu.:425.0   3rd Qu.:466.5  
##  Max.   :47.00   Max.   :61.0   Max.   :14.0   Max.   :568.0   Max.   :612.0  
##  NA's   :1       NA's   :4      NA's   :4                      NA's   :1      
##   dist_parc_2     d1_dist_parc      d2_dist_parc     d3_dist_parc  
##  Min.   :255.0   Min.   :-115.00   Min.   :-53.00   Min.   : -8.0  
##  1st Qu.:367.0   1st Qu.:   7.25   1st Qu.:  9.50   1st Qu.: 50.0  
##  Median :470.0   Median :  60.50   Median : 27.50   Median : 85.0  
##  Mean   :465.8   Mean   :  43.88   Mean   : 44.25   Mean   :127.4  
##  3rd Qu.:560.0   3rd Qu.:  81.25   3rd Qu.: 63.75   3rd Qu.:150.0  
##  Max.   :630.0   Max.   : 147.00   Max.   :165.00   Max.   :442.0  
##                  NA's   :1         NA's   :1                       
##  age_1ere.intervention delais_interventions_mois delais_interventions_jours
##  Min.   :49.26         Min.   : 0.630            Min.   : 19.0             
##  1st Qu.:63.01         1st Qu.: 6.330            1st Qu.:190.0             
##  Median :64.49         Median : 6.630            Median :199.0             
##  Mean   :65.52         Mean   : 7.761            Mean   :232.9             
##  3rd Qu.:73.42         3rd Qu.: 8.600            3rd Qu.:258.0             
##  Max.   :75.14         Max.   :16.530            Max.   :496.0             
## 

Données

describe(Limouse,num.desc=c("mean","median","sd","valid.n"),xname=NA,horizontal=FALSE)
## Description of Limouse
## 
##  Numeric 
##                                mean   median      sd valid.n
## patients                       5.00     5.00    2.74       9
## nbre_.valve_1                  6.22     6.00    1.86       9
## nbre_valve_2                   5.89     6.00    1.17       9
## volume_lobe_T._0A           1685.22  1544.00  658.42       9
## volume_lobe.T_.2A            620.33   804.00  531.09       9
## d_volume_Lobe_A            -1064.89  -930.00  669.04       9
## volume._lobe_T._0B          1476.11  1350.00  403.26       9
## volum_.lobe_T._.2B           318.33   200.00  300.48       9
## d_volume_Lobe_B            -1157.78 -1152.00  593.71       9
## P_perf_lobe_T_A                8.02     9.00    4.31       9
## P_perf_lobe_T_B                7.36     8.10    3.96       7
## MMRC_0                         3.22     3.00    0.44       9
## MMRC_1                         2.22     2.00    0.44       9
## MMRC_2                         2.00     2.00    0.71       9
## d1_MMRC                       -1.00    -1.00    0.50       9
## d2_MMRC                       -0.22     0.00    0.83       9
## d3_MMRC                       -1.22    -1.00    0.67       9
## BODE_0                         6.00     7.00    2.18       9
## BODE_1                         4.33     4.00    1.66       9
## BODE_2                         2.89     2.00    1.17       9
## d1_BODE                       -1.67    -1.00    1.50       9
## d2_BODE                       -1.44    -2.00    1.01       9
## d3_BODE                       -3.11    -3.00    2.15       9
## VEMS_ml_0                    918.89   860.00  397.54       9
## VEMS_ml_1                   1204.44  1070.00  494.65       9
## VEMS_ml_2                   1447.78  1500.00  393.53       9
## d1_VEMS_ml                   285.56   230.00  206.22       9
## d2_VEMS_ml                   243.33   250.00  254.61       9
## d3_VEMS_ml                   528.89   500.00  223.35       9
## VEMS._._0                     34.98    30.00   11.86       9
## VEMS_.._1                     45.33    47.00   12.17       9
## VEMS_.._2                     57.00    59.00   11.74       9
## d1_VEMS_.                     10.36    10.00    5.77       9
## d2_VEMS_.                     11.67    13.00    8.56       9
## d3_VEMS_.                     22.02    21.00    8.96       9
## VR_ml_0                     5511.11  5140.00 1309.52       9
## VR_ml._1                    4489.78  4470.00  741.40       9
## VR_ml_2                     3830.89  3730.00  621.89       9
## d1_VR_ml                   -1021.33  -580.00  913.61       9
## d2_VR_ml                    -658.89  -740.00  616.34       9
## d3_VR_ml                   -1680.22 -1270.00 1101.73       9
## VR_._0                       248.11   231.00   49.70       9
## VR_.._1                      204.78   193.00   35.71       9
## VR_.._2                      170.67   169.00   23.92       9
## d1_._VR                      -43.33   -29.00   36.32       9
## d2_._VR                      -34.11   -37.00   28.75       9
## d3_._VR                      -77.44   -68.00   47.61       9
## TLCO._0                       32.12    31.50   11.42       8
## TLCO_2                        36.20    32.00   15.77       5
## d_TLCO                         5.20     4.00    6.30       5
## dist_parc_0                  338.33   300.00  160.94       9
## dist_parc_1                  401.62   395.00  138.32       8
## dist_parc_2                  465.78   470.00  133.57       9
## d1_dist_parc                  43.88    60.50   80.20       8
## d2_dist_parc                  44.25    27.50   75.78       8
## d3_dist_parc                 127.44    85.00  135.40       9
## age_1ere.intervention         65.52    64.49    8.49       9
## delais_interventions_mois      7.76     6.63    4.81       9
## delais_interventions_jours   232.89   199.00  144.22       9
## 
##  Factor 
##               
## étio.emphysème Tabac Def A1AT
##        Count    8.00     1.00
##        Percent 88.89    11.11
## Mode Tabac 
##              
## Lobe.A.choisi   LIG   LID   LSD LSDLM   LSG
##       Count    3.00  2.00  2.00  1.00  1.00
##       Percent 33.33 22.22 22.22 11.11 11.11
## Mode LIG 
##              
## lobe_B_choisi   LID   LSG   LIG LSDLM
##       Count    3.00  3.00  2.00  1.00
##       Percent 33.33 33.33 22.22 11.11
## Mode >1 mode

Comparaison des médianes

La comparaison a été faite avec la méthode de Wilcoxon rank avec correction continue

Volume Lobe traité 1

wilcox.test(Limouse$volume_lobe.T_.2A,Limouse$volume_lobe_T._0A, paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$volume_lobe.T_.2A and Limouse$volume_lobe_T._0A
## V = 0, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

il y ’a une difference significative entre le volume avant et apres traitement la p-value<0.05.

pour valider que le volume du lobe traité après traitement est significativement inferieur à celui d’apres traitement

wilcox.test(Limouse$volume_lobe.T_.2A,Limouse$volume_lobe_T._0A, paired = TRUE,alternative = "less")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$volume_lobe.T_.2A and Limouse$volume_lobe_T._0A
## V = 0, p-value = 0.001953
## alternative hypothesis: true location shift is less than 0

dans ce cas la p-value est aussi < 0.05 validant le sens de la difference :diminution du volume

Volume Lobe traité 2

wilcox.test(Limouse$volume._lobe_T._0B,Limouse$volum_.lobe_T._.2B,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$volume._lobe_T._0B and Limouse$volum_.lobe_T._.2B
## V = 45, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

il y ’a une difference significative entre le volume avant et apres traitement la p-value<0.05.

pour valider que le volume du lobe traité après traitement est significativement inferieur à celui d’apres traitement

wilcox.test(Limouse$volum_.lobe_T._.2B,Limouse$volume._lobe_T._0B, paired = TRUE,alternative = "less")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$volum_.lobe_T._.2B and Limouse$volume._lobe_T._0B
## V = 0, p-value = 0.001953
## alternative hypothesis: true location shift is less than 0

dans ce cas la p-value est aussi < 0.05 validant le sens de la difference : diminution du volume

MMRC

MMRC V1-V0

wilcox.test(Limouse$MMRC_1,Limouse$MMRC_0,paired = TRUE)
## Warning in wilcox.test.default(Limouse$MMRC_1, Limouse$MMRC_0, paired = TRUE):
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$MMRC_1, Limouse$MMRC_0, paired = TRUE):
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$MMRC_1 and Limouse$MMRC_0
## V = 0, p-value = 0.008334
## alternative hypothesis: true location shift is not equal to 0

la difference entre la MMRC avant traitement et apres traitement du premier lobe est significative

wilcox.test(Limouse$MMRC_1,Limouse$MMRC_0,paired = TRUE,alternative = "less")
## Warning in wilcox.test.default(Limouse$MMRC_1, Limouse$MMRC_0, paired = TRUE, :
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$MMRC_1, Limouse$MMRC_0, paired = TRUE, :
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$MMRC_1 and Limouse$MMRC_0
## V = 0, p-value = 0.004167
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution de la MMRC entre la V0 et la V1

MMRC V2-V1

wilcox.test(Limouse$MMRC_2,Limouse$MMRC_1,paired = TRUE)
## Warning in wilcox.test.default(Limouse$MMRC_2, Limouse$MMRC_1, paired = TRUE):
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$MMRC_2, Limouse$MMRC_1, paired = TRUE):
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$MMRC_2 and Limouse$MMRC_1
## V = 7, p-value = 0.484
## alternative hypothesis: true location shift is not equal to 0

la difference entre la MMRC après traitement du 1er lobe (avant ttt 2ème lobe) et apres traitement du 2ème lobe n’est pas significatif

MMRC V2-V0

wilcox.test(Limouse$MMRC_2,Limouse$MMRC_0,paired = TRUE)
## Warning in wilcox.test.default(Limouse$MMRC_2, Limouse$MMRC_0, paired = TRUE):
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$MMRC_2, Limouse$MMRC_0, paired = TRUE):
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$MMRC_2 and Limouse$MMRC_0
## V = 0, p-value = 0.01154
## alternative hypothesis: true location shift is not equal to 0

la difference entre la MMRC avant traitement et apres traitement des 2 lobes est significative

wilcox.test(Limouse$MMRC_2,Limouse$MMRC_0,paired = TRUE,alternative = "less")
## Warning in wilcox.test.default(Limouse$MMRC_2, Limouse$MMRC_0, paired = TRUE, :
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$MMRC_2, Limouse$MMRC_0, paired = TRUE, :
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$MMRC_2 and Limouse$MMRC_0
## V = 0, p-value = 0.00577
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution de la MMRC entre la V0 et la V2

BODE

BODE V1-V0

wilcox.test(Limouse$BODE_1,Limouse$BODE_0,paired = TRUE)
## Warning in wilcox.test.default(Limouse$BODE_1, Limouse$BODE_0, paired = TRUE):
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$BODE_1, Limouse$BODE_0, paired = TRUE):
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$BODE_1 and Limouse$BODE_0
## V = 0, p-value = 0.01198
## alternative hypothesis: true location shift is not equal to 0

la difference entre BODE avant traitement et apres traitement du 1er lobe est significative

wilcox.test(Limouse$BODE_1,Limouse$BODE_0,paired = TRUE,alternative = "less")
## Warning in wilcox.test.default(Limouse$BODE_1, Limouse$BODE_0, paired = TRUE, :
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$BODE_1, Limouse$BODE_0, paired = TRUE, :
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$BODE_1 and Limouse$BODE_0
## V = 0, p-value = 0.005988
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution de la BODE entre la V0 et la V1

BODE V2-V1

wilcox.test(Limouse$BODE_2,Limouse$BODE_1,paired = TRUE)
## Warning in wilcox.test.default(Limouse$BODE_2, Limouse$BODE_1, paired = TRUE):
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$BODE_2, Limouse$BODE_1, paired = TRUE):
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$BODE_2 and Limouse$BODE_1
## V = 0, p-value = 0.01991
## alternative hypothesis: true location shift is not equal to 0

la difference entre BODE après ttt du 1er lobe (avant ttt 2ee lobe) et apres traitement du 2eme lobe est significative

wilcox.test(Limouse$BODE_2,Limouse$BODE_1,paired = TRUE,alternative = "less")
## Warning in wilcox.test.default(Limouse$BODE_2, Limouse$BODE_1, paired = TRUE, :
## cannot compute exact p-value with ties
## Warning in wilcox.test.default(Limouse$BODE_2, Limouse$BODE_1, paired = TRUE, :
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$BODE_2 and Limouse$BODE_1
## V = 0, p-value = 0.009953
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution

BODE V2-V0

wilcox.test(Limouse$BODE_2,Limouse$BODE_0,paired = TRUE)
## Warning in wilcox.test.default(Limouse$BODE_2, Limouse$BODE_0, paired = TRUE):
## cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$BODE_2 and Limouse$BODE_0
## V = 0, p-value = 0.008789
## alternative hypothesis: true location shift is not equal to 0

la difference entre BODE avant traitement et apres traitement des 2 lobes est significative

wilcox.test(Limouse$BODE_2,Limouse$BODE_0,paired = TRUE,alternative = "less")
## Warning in wilcox.test.default(Limouse$BODE_2, Limouse$BODE_0, paired = TRUE, :
## cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$BODE_2 and Limouse$BODE_0
## V = 0, p-value = 0.004394
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution de la BODE

VEMS en ml

VEMS (ml) V1-V0

wilcox.test(Limouse$VEMS_ml_1,Limouse$VEMS_ml_0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_ml_1 and Limouse$VEMS_ml_0
## V = 45, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

La difference entre la VEMS avant traitement et aprés traitement du 1er lobe est significative

wilcox.test(Limouse$VEMS_ml_1,Limouse$VEMS_ml_0,paired = TRUE,alternative = "greater")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_ml_1 and Limouse$VEMS_ml_0
## V = 45, p-value = 0.001953
## alternative hypothesis: true location shift is greater than 0

la difference est significative dans le sens d’une augmentation de la VEMS

VEMS (ml) V2-V1

wilcox.test(Limouse$VEMS_ml_2,Limouse$VEMS_ml_1,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_ml_2 and Limouse$VEMS_ml_1
## V = 41, p-value = 0.02734
## alternative hypothesis: true location shift is not equal to 0

la difference entre la VEMS après ttt du 1er lobe (avant ttt 2eme lobe) et apres traitement du 2eme lobe est significative

wilcox.test(Limouse$VEMS_ml_2,Limouse$VEMS_ml_1,paired = TRUE,alternative = "greater")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_ml_2 and Limouse$VEMS_ml_1
## V = 41, p-value = 0.01367
## alternative hypothesis: true location shift is greater than 0

la difference est significative dans le sens d’une augmentation

VEMS (ml) V2-V0

wilcox.test(Limouse$VEMS_ml_2,Limouse$VEMS_ml_0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_ml_2 and Limouse$VEMS_ml_0
## V = 45, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

la difference entre la VEMS avant traitement et apres traitement des 2 lobes est significative

wilcox.test(Limouse$VEMS_ml_2,Limouse$VEMS_ml_0,paired = TRUE,alternative = "greater")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_ml_2 and Limouse$VEMS_ml_0
## V = 45, p-value = 0.001953
## alternative hypothesis: true location shift is greater than 0

la difference est significative dans le sens d’une augmentation de la VEMS

VEMS en %

VEMS (%) V1-V0

wilcox.test(Limouse$VEMS_.._1,Limouse$VEMS._._0,paired = TRUE)
## Warning in wilcox.test.default(Limouse$VEMS_.._1, Limouse$VEMS._._0, paired =
## TRUE): cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$VEMS_.._1 and Limouse$VEMS._._0
## V = 45, p-value = 0.009091
## alternative hypothesis: true location shift is not equal to 0

La difference entre le pourcentage de la VEMS avant traitement et aprés traitement du 1er lobe est significative

wilcox.test(Limouse$VEMS_.._1,Limouse$VEMS._._0,paired = TRUE,alternative = "greater")
## Warning in wilcox.test.default(Limouse$VEMS_.._1, Limouse$VEMS._._0, paired =
## TRUE, : cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$VEMS_.._1 and Limouse$VEMS._._0
## V = 45, p-value = 0.004545
## alternative hypothesis: true location shift is greater than 0

la difference est significative dans le sens d’une augmentation du pourcenatge la VEMS

VEMS (%) V2-V1

wilcox.test(Limouse$VEMS_.._2,Limouse$VEMS_.._1,paired = TRUE)
## Warning in wilcox.test.default(Limouse$VEMS_.._2, Limouse$VEMS_.._1, paired =
## TRUE): cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$VEMS_.._2 and Limouse$VEMS_.._1
## V = 44, p-value = 0.01277
## alternative hypothesis: true location shift is not equal to 0

la difference entre la VEMS après ttt du 1er lobe (avant ttt 2eme lobe) et apres traitement du 2eme lobe est significative

wilcox.test(Limouse$VEMS_.._2,Limouse$VEMS_.._1,paired = TRUE,alternative = "greater")
## Warning in wilcox.test.default(Limouse$VEMS_.._2, Limouse$VEMS_.._1, paired =
## TRUE, : cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$VEMS_.._2 and Limouse$VEMS_.._1
## V = 44, p-value = 0.006386
## alternative hypothesis: true location shift is greater than 0

la difference est significative dans le sens d’une augmentation

VEMS V2-V0

wilcox.test(Limouse$VEMS_.._2,Limouse$VEMS._._0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_.._2 and Limouse$VEMS._._0
## V = 45, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

la difference entre la VEMS avant traitement et apres traitement des 2 lobes est significative

wilcox.test(Limouse$VEMS_.._2,Limouse$VEMS._._0,paired = TRUE,alternative = "greater")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VEMS_.._2 and Limouse$VEMS._._0
## V = 45, p-value = 0.001953
## alternative hypothesis: true location shift is greater than 0

la difference est significative dans le sens d’une augmentation de la VEMS

VR en ml

VR (ml) V1-V0

wilcox.test(Limouse$VR_ml._1,Limouse$VR_ml_0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_ml._1 and Limouse$VR_ml_0
## V = 0, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

La difference entre le VR avant traitement et aprés traitement du 1er lobe est significative

wilcox.test(Limouse$VR_ml._1,Limouse$VR_ml_0,paired = TRUE,alternative = "less")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_ml._1 and Limouse$VR_ml_0
## V = 0, p-value = 0.001953
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution du VR

VR (ml) V2-V1

wilcox.test(Limouse$VR_ml_2,Limouse$VR_ml._1,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_ml_2 and Limouse$VR_ml._1
## V = 4, p-value = 0.02734
## alternative hypothesis: true location shift is not equal to 0

la difference entre le VR après ttt du 1er lobe (avant ttt 2eme lobe) et apres traitement du 2eme lobe est significative

wilcox.test(Limouse$VR_ml_2,Limouse$VR_ml._1,paired = TRUE,alternative = "less")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_ml_2 and Limouse$VR_ml._1
## V = 4, p-value = 0.01367
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution

VR (ml) V2-V0

wilcox.test(Limouse$VR_ml_2,Limouse$VR_ml_0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_ml_2 and Limouse$VR_ml_0
## V = 0, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

la difference entre le VR avant traitement et apres traitement des 2 lobes est significative

wilcox.test(Limouse$VR_ml_2,Limouse$VR_ml_0,paired = TRUE,alternative = "less")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_ml_2 and Limouse$VR_ml_0
## V = 0, p-value = 0.001953
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution

VR en %

VR (%) V1-V0

wilcox.test(Limouse$VR_.._1,Limouse$VR_._0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_.._1 and Limouse$VR_._0
## V = 0, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

La difference entre le pourcentage du VR avant traitement et aprés traitement du 1er lobe est significative

wilcox.test(Limouse$VR_.._1,Limouse$VR_._0,paired = TRUE,alternative = "less")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_.._1 and Limouse$VR_._0
## V = 0, p-value = 0.001953
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution

VR (%) V2-V1

wilcox.test(Limouse$VR_.._2,Limouse$VR_.._1,paired = TRUE)
## Warning in wilcox.test.default(Limouse$VR_.._2, Limouse$VR_.._1, paired = TRUE):
## cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$VR_.._2 and Limouse$VR_.._1
## V = 2, p-value = 0.01772
## alternative hypothesis: true location shift is not equal to 0

la difference entre le %age du VR après ttt du 1er lobe (avant ttt 2eme lobe) et apres traitement du 2eme lobe est significative

wilcox.test(Limouse$VR_.._2,Limouse$VR_.._1,paired = TRUE,alternative = "less")
## Warning in wilcox.test.default(Limouse$VR_.._2, Limouse$VR_.._1, paired =
## TRUE, : cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$VR_.._2 and Limouse$VR_.._1
## V = 2, p-value = 0.008859
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution

VR (%)V2-V0

wilcox.test(Limouse$VR_.._2,Limouse$VR_._0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_.._2 and Limouse$VR_._0
## V = 0, p-value = 0.003906
## alternative hypothesis: true location shift is not equal to 0

la difference entre le % du VR avant traitement et apres traitement des 2 lobes est significative

wilcox.test(Limouse$VR_.._2,Limouse$VR_._0,paired = TRUE,alternative = "less")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$VR_.._2 and Limouse$VR_._0
## V = 0, p-value = 0.001953
## alternative hypothesis: true location shift is less than 0

la difference est significative dans le sens d’une diminution

TLCO

wilcox.test(Limouse$TLCO_2,Limouse$TLCO._0,paired = TRUE)
## Warning in wilcox.test.default(Limouse$TLCO_2, Limouse$TLCO._0, paired = TRUE):
## cannot compute exact p-value with zeroes
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$TLCO_2 and Limouse$TLCO._0
## V = 9, p-value = 0.2012
## alternative hypothesis: true location shift is not equal to 0

p value TLCO EST non significative

distance parcourue TM6

Distance parcourue V1-V0

wilcox.test(Limouse$dist_parc_1,Limouse$dist_parc_0,paired = TRUE)
## Warning in wilcox.test.default(Limouse$dist_parc_1, Limouse$dist_parc_0, :
## cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$dist_parc_1 and Limouse$dist_parc_0
## V = 29.5, p-value = 0.123
## alternative hypothesis: true location shift is not equal to 0

la difference de distance parcourue (TM6) avant ttt et après ttt du premier lobe est non significative

wilcox.test(Limouse$dist_parc_1,Limouse$dist_parc_0,paired = TRUE,alternative = "greater")
## Warning in wilcox.test.default(Limouse$dist_parc_1, Limouse$dist_parc_0, :
## cannot compute exact p-value with ties
## 
##  Wilcoxon signed rank test with continuity correction
## 
## data:  Limouse$dist_parc_1 and Limouse$dist_parc_0
## V = 29.5, p-value = 0.06151
## alternative hypothesis: true location shift is greater than 0

la difference de distance parcourue est non significative cependant la distance de la V1 tend a etre plus grande que la V0

Distance parcourue V2-V1

wilcox.test(Limouse$dist_parc_2,Limouse$dist_parc_1,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$dist_parc_2 and Limouse$dist_parc_1
## V = 29, p-value = 0.1484
## alternative hypothesis: true location shift is not equal to 0

la difference de distance parcourue (TM6) apres ttt du 1er lobe et après ttt du 2eme lobe est non significative

wilcox.test(Limouse$dist_parc_2,Limouse$dist_parc_1,paired = TRUE,alternative = "greater")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$dist_parc_2 and Limouse$dist_parc_1
## V = 29, p-value = 0.07422
## alternative hypothesis: true location shift is greater than 0

la difference est non significative

Distance parcourue V2-V0

wilcox.test(Limouse$dist_parc_2,Limouse$dist_parc_0,paired = TRUE)
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$dist_parc_2 and Limouse$dist_parc_0
## V = 44, p-value = 0.007812
## alternative hypothesis: true location shift is not equal to 0

la difference entre la distance parcourue (TM6) avant traitement et apres traitement des 2 lobes est significative

wilcox.test(Limouse$dist_parc_2,Limouse$dist_parc_0,paired = TRUE,alternative = "greater")
## 
##  Wilcoxon signed rank exact test
## 
## data:  Limouse$dist_parc_2 and Limouse$dist_parc_0
## V = 44, p-value = 0.003906
## alternative hypothesis: true location shift is greater than 0

la difference est significative dans le sens d’une augmentation