1 Methods

2 Results

Table 1: Summary table of all relevant variables by sex.

2.1 Correlation Matrix

Correlations / Cirrhosis, fibrosis, Steatosis

“Fibroscan fibrosis stage” “Cirrhosis” “CAP Steatosis stage”

2.1.1 General

2.1.2 / Cirrhosis

Cirrhosis: yes

Cirrhosis: no

2.1.3 / Fibroscan fibrosis stage

Fibroscan fibrosis stage: F0-F2 (≤10)

Fibroscan fibrosis stage: F3-F4 (>10)

2.1.4 / CAP Steatosis stage

CAP Steatosis stage: No steatosis

CAP Steatosis stage: S1-S2 (260-294)

CAP Steatosis stage: S3 (≥295)

2.2 Scatter Plots

### CAP_Value

### HRI Mean

### Fibroscan_Value

### Attenuation Mean

### Elastography liver median 1

### Viscosity liver Median 1

### Elastography spleen median 1

### Viscosity spleen Median 1

## Scatter Plots 2

  Viscosity liver Median 1 Viscosity liver Median 1 Viscosity liver Median 1 Viscosity liver Median 1
Predictors Estimates CI p Estimates CI p Estimates CI p Estimates CI p
(Intercept) 0.91 0.66 – 1.16 <0.001 0.86 0.28 – 1.44 0.004 0.78 0.27 – 1.30 0.003 0.86 0.28 – 1.44 0.004
log2(Fibroscan_Value) 0.42 0.35 – 0.48 <0.001 0.43 0.36 – 0.50 <0.001 0.44 0.37 – 0.51 <0.001 0.44 0.36 – 0.52 <0.001
log2(GOT) 0.00 -0.12 – 0.12 0.981 -0.02 -0.22 – 0.18 0.822
log2(GPT) 0.01 -0.08 – 0.11 0.807 0.02 -0.13 – 0.18 0.765
Observations 191 167 168 167
R2 / R2 adjusted 0.456 / 0.453 0.489 / 0.483 0.497 / 0.491 0.490 / 0.480
  CAP_Value CAP_Value
Predictors Estimates CI p Estimates CI p
(Intercept) 215.48 180.25 – 250.70 <0.001 126.94 58.45 – 195.42 <0.001
HRI Mean 41.98 14.19 – 69.76 0.003 30.16 2.36 – 57.95 0.034
HRI Depth Liver Mean 13.32 5.62 – 21.02 0.001
HRI number measurements 1.08 -8.78 – 10.95 0.828
Observations 146 146
R2 / R2 adjusted 0.058 / 0.052 0.131 / 0.112
  CAP_Value CAP_Value
Predictors Estimates CI p Estimates CI p
(Intercept) 161.00 132.80 – 189.21 <0.001 170.42 128.24 – 212.60 <0.001
Attenuation Mean 240.30 178.02 – 302.58 <0.001 244.65 180.62 – 308.69 <0.001
Number Attenuation
measurements 		-2.34 -10.12 – 5.44 0.554
Observations 201 201
R2 / R2 adjusted 0.225 / 0.221 0.227 / 0.219

viscosity ~ fibroscan + got, gpt

“Viscosity liver Median 1” “Fibroscan_Value” “GOT” “GPT”

cap ~ hri, attenuatin + depth + nr W(masuratori)

“CAP_Value”

“HRI Mean” “HRI number measurements” “HRI Depth Liver Mean” “HRI Depth Renal Mean”

“Attenuation Mean” “Number Attenuation measurements”

2.3 AUC

2.3.1 HRI Mean ~ CAP Steatosis stage, general

2.3.2 HRI Mean ~ CAP Steatosis stage, Fibroscan fibrosis stage: F0-F2 (≤10)

2.3.3 HRI Mean ~ CAP Steatosis stage, Fibroscan fibrosis stage: F3-F4 (>10)

2.3.4 HRI Mean ~ CAP Steatosis stage, Etiology: alcohol

! S2 / S3: AUC < 50% !

2.3.5 HRI Mean ~ CAP Steatosis stage, Etiology: viral

2.3.6 HRI Mean ~ CAP Steatosis stage, Etiology: metabolic

2.3.7 Attenuation Mean ~ CAP Steatosis stage, general

2.3.8 Attenuation Mean ~ CAP Steatosis stage, Fibroscan fibrosis stage: F0-F2 (≤10)

2.3.9 Attenuation Mean ~ CAP Steatosis stage, Fibroscan fibrosis stage: F3-F4 (>10)

2.3.10 Attenuation Mean ~ CAP Steatosis stage, Etiology: alcohol

2.3.11 Attenuation Mean ~ CAP Steatosis stage, Etiology: viral

2.3.12 Attenuation Mean ~ CAP Steatosis stage, Etiology: metabolic

2.3.13 Viscosity liver ~ Fibroscan fibrosis stage, general

2.3.14 Viscosity liver ~ Fibroscan fibrosis stage, CAP Steatosis stage = No steatosis

2.3.15 Viscosity liver ~ Fibroscan fibrosis stage, CAP Steatosis stage = S1-S2 (260-294)

2.3.16 Viscosity liver ~ Fibroscan fibrosis stage, CAP Steatosis stage = S3 (≥295)

2.3.17 Viscosity liver ~ Fibroscan fibrosis stage, Etiology: alcohol

2.3.18 Viscosity liver ~ Fibroscan fibrosis stage, Etiology: viral

2.3.19 Viscosity liver ~ Fibroscan fibrosis stage, Etiology: metabolic

viscosity ~ fibroscan + got, gpt

“Viscosity liver Median 1” “Fibroscan_Value” “GOT” “GPT”

cap ~ hri, attenuatin + depth + nr W(masuratori)

“CAP_Value”

“HRI Mean” “HRI number measurements” “HRI Depth Liver Mean” “HRI Depth Renal Mean”

“Attenuation Mean” “Number Attenuation measurements”

corel / chirfosis, fibrisis, steatosis

“Fibroscan fibrosis stage” “Cirrhosis” “CAP Steatosis stage”

auc: hri, attenuatin ~ steatosis / etiology, fibrosis

auc: viscosity ~ fibrosis / etiology, steatosis

“HRI Mean” “Attenuation Mean” “Viscosity liver Median 1”

“CAP Steatosis stage” “Fibroscan fibrosis stage” “Etiology2”

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