Mutated genes in cancer - an interactive Shiny app

Cancer & genome sequencing

The majority of cancers are caused by somatic genetic alterations

The advent of second-generation DNA sequencing technologies permit high-throughput identificiation of the mutation spectrum in tumor samples

Knowledge of the mutation spectrum in each tumor would pave the way for more personalized treatment strategies

Genome sequencing in cancer forms the foundation of precision medicine - a new era in modern medicine

What is the current status of cancer genome sequencing results - in terms of druggability and known cancer associations?

Mutation data has been downloaded from The Cancer Genome Atlas
(R expression): Across 14 TCGA sample cohorts, the median number of samples per cohort was 262 (max: 955, min: 159)
Data on genes with known cancer association were downloaded from the Wellcome Trust Sanger Institute
Data on genes/proteins being targeted by antineoplastic drugs were downloaded from the Gene Drug Interaction Database
A Shiny app was developed that allows the user to explore frequently mutated genes (for different tumor types) in context of druggability and known cancer association
Available through https://sigven78.shinyapps.io/mutated_cancer_genes/

viewed in context of druggability and known cancer associations