set-up

Dimensional reduction

Proportion KO-WT

In order to visualise the proportions from KO and WT for each cluster, we do not take in consideration the microglia, as these cells are only present in the control. We then normalise per number of cells per cluster.

##    Genotype         cluster Proportion
## 1        KO     Gran & Mono      91.16
## 2        KO     Lymphocytes      80.84
## 3        KO  ChP_epithelial      75.51
## 4        KO             DCs      73.82
## 5        KO     fEndothelia      68.13
## 6        KO         Oligo_1      66.57
## 7        KO         Oligo_2      65.33
## 8        KO        mNeurons      64.60
## 9        KO   Ependymocytes      61.57
## 10       KO     Endothelial      53.21
## 11       KO             OEG      52.75
## 12       KO iNeurons & NRPs      52.06
## 13       KO      OligoAstro      51.36
## 14       KO            OPCs      50.36
## 15       KO     Astrocyte_1      42.71
## 16       KO     Mural_cells      41.57
## 17       KO     Astrocyte_3      36.28
## 18       KO     Astrocyte_2      32.74
## 19       KO            BAMs      31.54

visualise in a plot