1 Methods

2 Results

2.1 Univariate analysis of selected variables by Year (2021 vs 2020)

Table 1: Univariate analysis of some variables by year (2021 vs 2020, full descriptive table).

2.2 Univariate analysis of selected variables by COVID death

Table 2: Univariate analysis of some variables by COVID death (full descriptive table).

Table 3: Univariate analysis of some variables by COVID death (full descriptive table).

2.3 Univariate analysis of all variables by COVID death

Table 4: Univariate analysis of all variables by COVID death (full descriptive table).

Main

Admission

Day 0

Day 1

Day 3

Day 7

2.4 Univariate analysis of all variables by ICU admission

2.5 Univariate analysis of all variables by year (2021 vs 2020)

Table 5: Univariate analysis of all variables by year (2021 vs 2020, full descriptive table).

Main

Admission

Day 0

Day 1

Day 3

Day 7

2.6 Univariate analysis of all variables by Remdesivir administration

2.7 KM plot

2.8 CRP box-plot

2.9 IL6 box-plot

2.10 IL6 vio-plot

2.11 Logistic Regression 1

  Deceased
Predictors Odds Ratios CI p
(Intercept) 0.00 0.00 – 0.03 <0.001
Day 3: CRP >7.5 mg/dL: da 16.60 3.07 – 108.96 0.002
log2: Admission IL6
(pg/mL) 		1.23 0.85 – 1.85 0.285
Lung damage >40%: yes 11.68 2.05 – 224.98 0.024
TCZ >3 days after
admission: yes 		3.76 1.06 – 15.14 0.047
Cardiovascular
comorbidities (>2): yes 		3.65 1.06 – 12.53 0.037
Observations 154
R2 Tjur 0.245

2.12 Logistic Regression 2

  Deceased
Predictors Odds Ratios CI p
(Intercept) 0.00 0.00 – 0.02 <0.001
Age (years) 1.25 0.81 – 1.97 0.318
log2: Admission IL6
(pg/mL) 		1.27 0.93 – 1.79 0.139
Lung damage >40%: yes 15.64 2.94 – 292.81 0.010
TCZ >3 days after
admission: yes 		3.51 1.22 – 10.89 0.023
Cardiovascular
comorbidities (>2): yes 		3.64 1.21 – 11.14 0.021
Observations 190
R2 Tjur 0.164

2.13 Logistic Regression 3

  ICU admission
Predictors Odds Ratios CI p
(Intercept) 0.29 0.02 – 3.76 0.346
Age (years) 0.67 0.48 – 0.92 0.016
log2: Admission IL6
(pg/mL) 		1.11 0.89 – 1.40 0.346
Lung damage >40%: yes 10.93 4.08 – 38.27 <0.001
TCZ >3 days after
admission: yes 		1.37 0.64 – 2.97 0.422
Cardiovascular
comorbidities (>2): yes 		3.40 1.38 – 8.75 0.009
Observations 190
R2 Tjur 0.197

2.14 Logistic Regression 4

  Deceased
Predictors Odds Ratios CI p
(Intercept) 0.00 0.00 – 0.00 <0.001
log2: IL6 (pg/mL) 1.84 1.18 – 3.03 0.010
Age (years) 1.07 1.02 – 1.12 0.004
Lung damage >40%: yes 7.01 1.20 – 134.06 0.074
Sepsis/Pneumonia: yes 19.59 3.79 – 131.34 0.001
ICU admission: yes 3.61 1.19 – 11.56 0.025
TCZ >3 days after
admission: yes 		2.34 0.81 – 7.14 0.121
Observations 221
R2 Tjur 0.354

2.15 Logistic Regression 5

  Deceased
Predictors Odds Ratios CI p
(Intercept) 0.00 0.00 – 0.00 <0.001
Day 3: CRP >7.5 mg/dL: da 13.11 2.25 – 89.52 0.005
log2: Day 0 IL6 (pg/mL) 1.77 1.10 – 3.05 0.026
Lung damage >40%: yes 11.61 2.03 – 223.76 0.025
TCZ >3 days after
admission: yes 		3.14 1.03 – 10.78 0.052
Cardiovascular
comorbidities (>2): yes 		3.81 1.14 – 12.82 0.028
Observations 177
R2 Tjur 0.283

3 Extra box-plots

3.0.1 IL6 (pg/mL)

3.0.2 WBC (*1000/uL)

3.0.3 PMN (*1000/uL)

3.0.4 Lymphocytes (*1000/uL)

3.0.5 Platelets (*1000/uL)

3.0.6 Hemoglobin (g/dL)

3.0.7 Fibrinogen (mg/dL)

3.0.8 D-dimer (mg/L)

3.0.9 CRP (mg/dL)

3.0.10 PCT (ng/mL)

3.0.11 Ferritin (ng/mL)

3.0.12 ALT (U/L)

3.0.13 AST (U/L)

3.0.14 LDH (U/L)

3.0.15 All together

.