Tabla comparacion grupos tratamiento primeras 48h.
Comparativa grupos dosis HBPM
profilaxis tratamiento p test
n 258 462
dias_uci_alta (median [IQR]) 15.00 [8.00, 26.00] 16.00 [10.00, 25.75] 0.292 nonnorm
dias_sint_uci (median [IQR]) 9.00 [7.00, 12.00] 10.00 [7.00, 13.00] 0.547 nonnorm
dias_sint_hos (median [IQR]) 7.00 [5.00, 9.00] 7.00 [5.00, 9.00] 0.658 nonnorm
edad (median [IQR]) 63.00 [55.00, 70.00] 63.50 [56.00, 71.00] 0.196 nonnorm
sexo = female (%) 84 (32.7) 149 (32.4) 1.000
imc (median [IQR]) 29.00 [26.00, 32.00] 29.00 [26.00, 32.00] 0.803 nonnorm
ttoaap = TRUE (%) 30 (11.6) 39 ( 8.4) 0.207
ttaco = TRUE (%) 16 ( 6.2) 27 ( 5.8) 0.976
apache (median [IQR]) 12.00 [8.00, 16.00] 11.50 [9.00, 17.00] 0.775 nonnorm
sofa (median [IQR]) 7.00 [4.00, 8.00] 7.00 [4.00, 9.00] 0.228 nonnorm
curb (median [IQR]) 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] 0.333 nonnorm
pafi3 (%) 0.112
(41,100] 25 (10.8) 71 (15.9)
(100,200] 134 (57.8) 227 (50.8)
(200,486] 73 (31.5) 149 (33.3)
ferritina (median [IQR]) 1,474.00 [780.00, 3,732.00] 1,613.00 [907.00, 3,654.50] 0.380 nonnorm
DD (median [IQR]) 2,200.00 [800.00, 6,500.00] 2,040.00 [935.50, 7,675.00] 0.177 nonnorm
pcr (median [IQR]) 19.76 [10.41, 44.72] 44.75 [16.22, 196.00] <0.001 nonnorm
linfocito (median [IQR]) 0.70 [0.50, 1.00] 0.74 [0.50, 1.10] 0.388 nonnorm
ratio_pcrlinf (median [IQR]) 29.45 [13.39, 69.36] 66.67 [17.56, 254.75] <0.001 nonnorm
plaquetas (median [IQR]) 275.00 [208.50, 389.75] 268.50 [202.00, 433.50] 0.768 nonnorm
ldh (median [IQR]) 471.00 [371.50, 613.50] 479.00 [385.75, 602.50] 0.552 nonnorm
prcalc (median [IQR]) 0.28 [0.13, 0.67] 0.24 [0.12, 0.60] 0.304 nonnorm
aclr_creat (median [IQR]) 89.54 [63.61, 123.00] 87.01 [60.13, 116.50] 0.443 nonnorm
ventmax = yes (%) 193 (74.8) 405 (87.7) <0.001
prono = yes (%) 119 (46.1) 283 (61.3) <0.001
man_recl = yes (%) 93 (36.0) 240 (51.9) <0.001
ttoreljmus = yes (%) 136 (52.7) 294 (63.6) 0.005
ttorendesivir = yes (%) 6 ( 2.3) 6 ( 1.3) 0.466
ttointerf = yes (%) 53 (20.5) 111 (24.0) 0.329
ttotozi = yes (%) 93 (36.0) 187 (40.5) 0.276
ttocorti = yes (%) 135 (52.3) 284 (61.5) 0.021
Tabla comparacion grupos tratamiento pdurante estancia.
Comparativa grupos dosis HBPM
profilaxis tratamiento p test
n 258 462
ttnamax (median [IQR]) 0.20 [0.09, 0.40] 0.20 [0.10, 0.50] 0.432 nonnorm
ldhmax (median [IQR]) 570.50 [443.50, 979.00] 624.00 [471.00, 1,053.00] 0.047 nonnorm
prcalcmax (median [IQR]) 0.52 [0.19, 2.07] 0.62 [0.26, 3.09] 0.067 nonnorm
ecmo = yes (%) 0 (0.0) 2 (0.4) 0.749
extraco2 = yes (%) 0 (0.0) 1 (0.2) 1.000
Tabla comparacion grupos tratamiento resulados
Comparativa grupos dosis HBPM
profilaxis tratamiento p test
n 258 462
tipo_hemo (%) 0.553
no 233 (90.3) 421 (91.1)
menor 16 ( 6.2) 21 ( 4.5)
mayor 9 ( 3.5) 20 ( 4.3)
complica_trombe = TRUE (%) 20 ( 7.8) 49 (10.6) 0.265
fallece = TRUE (%) 65 (25.2) 162 (35.1) 0.008
Factores asociados a la eleccion dosis de tratamiento (primeros dos dias UCI)
  grupo
Predictors Odds Ratios CI p
edad 1.01 0.99 – 1.02 0.404
maleTRUE 0.91 0.64 – 1.29 0.603
pcr 1.00 1.00 – 1.01 <0.001
ventmax [yes] 1.94 1.17 – 3.22 0.010
man_recl 1.23 0.84 – 1.82 0.286
prono 1.46 1.03 – 2.07 0.032
ttoreljmus 0.75 0.48 – 1.14 0.182
ttotozi 1.22 0.87 – 1.71 0.259
ttocorti 1.62 1.17 – 2.26 0.004
Observations 720
R2 Tjur 0.090
Efecto del tipo de dosis sobre el fallecimiento (modelo marginal: inverse probability weighting)
  Mortality
Predictors Odds Ratios CI p
(Intercept) 0.39 0.30 – 0.51 <0.001
ET 1.30 0.94 – 1.82 0.120
Observations 720
R2 Tjur 0.006