PK_05142021
Bill Chen
5/14/2021
Loading data
library(readr)
study_MS038_1_Sheet1 <- read_csv("C:/Users/billc/Downloads/study_MS038 (1) - Sheet1.csv")##
## -- Column specification --------------------------------------------------------
## cols(
## `Group ID` = col_character(),
## `Animal ID` = col_double()
## )study_MS038_1_Sheet1 <- study_MS038_1_Sheet1[order(study_MS038_1_Sheet1$`Animal ID`),]
head(study_MS038_1_Sheet1)## # A tibble: 6 x 2
## `Group ID` `Animal ID`
## <chr> <dbl>
## 1 Aged 1
## 2 Aged 2
## 3 Aged 3
## 4 Aged 4
## 5 Aged 5
## 6 Aged+NaB 6temp_df <- read_csv("C:/Users/billc/Downloads/20210513 AAM-BLG-1 SA25 Service Report.xlsx - Data Normalization.csv", col_names = TRUE)##
## -- Column specification --------------------------------------------------------
## cols(
## .default = col_number(),
## Normalization = col_character()
## )
## i Use `spec()` for the full column specifications.colnames(temp_df) <- c('Normalization', paste(study_MS038_1_Sheet1$`Group ID`, study_MS038_1_Sheet1$`Animal ID`))
row_names <- temp_df$Normalization
temp_df <- temp_df[-1]
temp_df<- data.frame(temp_df)
row.names(temp_df) <- row_names
colnames(temp_df) <- paste(study_MS038_1_Sheet1$`Group ID`, study_MS038_1_Sheet1$`Animal ID`)
head(temp_df)## Aged 1 Aged 2 Aged 3 Aged 4 Aged 5 Aged+NaB 6 Aged+NaB 7
## POS-Ave 120414 120414 120414 120414 120414 120414 120414
## Neg-Ave 0 0 0 0 0 0 0
## 6Ckine 0 0 0 0 0 0 0
## Activin AÂ 517 0 0 0 57 93426 7081
## Activin C 0 0 0 0 0 0 0
## Activin RIB / ALK-4 0 0 0 0 0 0 0
## Aged+NaB 8 Aged+NaB 9 Aged+NaB 10 Aged+Combo 11
## POS-Ave 120414 120414 120414 120414
## Neg-Ave 0 0 0 0
## 6Ckine 0 0 728 2003
## Activin AÂ 0 1908 9512 4679
## Activin C 0 0 0 0
## Activin RIB / ALK-4 130 4388 1 0
## Aged+Combo 12 Aged+Combo 13 Aged+Combo 14 Aged+Combo 15
## POS-Ave 120414 120414 120414 120414
## Neg-Ave 0 0 0 0
## 6Ckine 1 0 0 0
## Activin AÂ 1883 1 10503 2543
## Activin C 0 0 0 0
## Activin RIB / ALK-4 0 0 704 1
## Aged+IGF2 16 Aged+IGF2 17 Aged+IGF2 18 Aged+IGF2 19
## POS-Ave 120414 120414 120414 120414
## Neg-Ave 0 0 0 0
## 6Ckine 0 1 0 1
## Activin AÂ 0 2873 1112 809
## Activin C 0 0 0 0
## Activin RIB / ALK-4 7093 0 0 0
## Aged+IGF2 20 Young 21 Young 22 Young 23 Young 24 Young 25
## POS-Ave 120414 120414 120414 120414 120414 120414
## Neg-Ave 0 0 0 0 0 0
## 6Ckine 345 720 0 1 0 0
## Activin AÂ 1175 4451 1926 4281 1724 2312
## Activin C 0 0 0 0 0 0
## Activin RIB / ALK-4 0 1666 2871 3258 1791 0# temp_anaysis_df <-
df <- scale(temp_df)
heatmap(df, scale = "row" )
library("pheatmap")## Warning: package 'pheatmap' was built under R version 4.0.5pheatmap(df, cutree_col = 4, labels_row=FALSE, scale='row')
# install.packages("gplots")
library("gplots")## Warning: package 'gplots' was built under R version 4.0.5##
## Attaching package: 'gplots'## The following object is masked from 'package:stats':
##
## lowessheatmap.2(df, scale = "none", col = bluered(100),
trace = "none", density.info = "none")
# install.packages('d3heatmap')
library("d3heatmap")
d3heatmap(scale(df), colors = "RdYlBu",
k_row = 4, # Number of groups in rows
k_col = 2 # Number of groups in columns
)for(dd_m in c("euclidean", "maximum", "manhattan", "canberra", "binary", "minkowski")){
for (hc_m in c("ward.D", "ward.D2", "single", "complete", "average", "mcquitty", "median", "centroid")){
dd <- dist(t(df), method = dd_m)
hc <- hclust(dd, method = hc_m)
plot(hc, labels = NULL, hang = 0.1,
main = paste("Biomarker", dd_m, hc_m), sub = NULL,
xlab = NULL, ylab = NULL)
}
}
Young vs Old
temp_df <- read_csv("C:/Users/billc/Downloads/20210513 AAM-BLG-1 SA25 Service Report.xlsx - Data Normalization.csv", col_names = TRUE)##
## -- Column specification --------------------------------------------------------
## cols(
## .default = col_number(),
## Normalization = col_character()
## )
## i Use `spec()` for the full column specifications.# colnames(temp_df) <- c('Normalization', paste(study_MS038_1_Sheet1$`Group ID`, study_MS038_1_Sheet1$`Animal ID`))
row_names <- temp_df$Normalization
temp_df <- temp_df[-1]
temp_df<- data.frame(temp_df)
row.names(temp_df) <- row_names
colnames(temp_df) <- paste(study_MS038_1_Sheet1$`Group ID`, study_MS038_1_Sheet1$`Animal ID`)
# temp_df
temp_df_y_o <- temp_df[c(1:5, 21:25)]
head(temp_df_y_o)## Aged 1 Aged 2 Aged 3 Aged 4 Aged 5 Young 21 Young 22
## POS-Ave 120414 120414 120414 120414 120414 120414 120414
## Neg-Ave 0 0 0 0 0 0 0
## 6Ckine 0 0 0 0 0 720 0
## Activin AÂ 517 0 0 0 57 4451 1926
## Activin C 0 0 0 0 0 0 0
## Activin RIB / ALK-4 0 0 0 0 0 1666 2871
## Young 23 Young 24 Young 25
## POS-Ave 120414 120414 120414
## Neg-Ave 0 0 0
## 6Ckine 1 0 0
## Activin AÂ 4281 1724 2312
## Activin C 0 0 0
## Activin RIB / ALK-4 3258 1791 0for(dd_m in c("euclidean", "maximum", "manhattan", "canberra", "binary", "minkowski")){
for (hc_m in c("ward.D", "ward.D2", "single", "complete", "average", "mcquitty", "median", "centroid")){
dd <- dist(t(temp_df_y_o), method = dd_m)
hc <- hclust(dd, method = hc_m)
plot(hc, labels = NULL, hang = 0.1,
main = paste("Biomarker", dd_m, hc_m), sub = NULL,
xlab = NULL, ylab = NULL)
}
}
Using mean instead of all data
temp_df <- read_csv("C:/Users/billc/Downloads/20210513 AAM-BLG-1 SA25 Service Report.xlsx - Data Normalization.csv", col_names = TRUE)##
## -- Column specification --------------------------------------------------------
## cols(
## .default = col_number(),
## Normalization = col_character()
## )
## i Use `spec()` for the full column specifications.# colnames(temp_df) <- c('Normalization', paste(study_MS038_1_Sheet1$`Group ID`, study_MS038_1_Sheet1$`Animal ID`))
row_names <- temp_df$Normalization
temp_df <- temp_df[-1]
temp_df<- data.frame(temp_df)
row.names(temp_df) <- row_names
colnames(temp_df) <- paste(study_MS038_1_Sheet1$`Group ID`)
temp_df## Aged Aged Aged Aged Aged
## POS-Ave 120414 120414 120414 120414 120414
## Neg-Ave 0 0 0 0 0
## 6Ckine 0 0 0 0 0
## Activin AÂ 517 0 0 0 57
## Activin C 0 0 0 0 0
## Activin RIB / ALK-4 0 0 0 0 0
## Adiponectin / Acrp30 634 0 0 1 0
## AgRP 1006 1 10447 0 2420
## ALCAM 0 0 0 0 0
## Angiopoietin-like 2 3132 11030 8425 1 6464
## Angiopoietin-like 3 1 2243 0 4209 2626
## AR (Amphiregulin) 198 17107 0 0 1
## Artemin 3574 12511 8301 3558 7136
## Axl 3939 7849 3707 0 3217
## b FGF 11451 10837 19665 3577 12836
## B7-1/CD80 6287 15048 2875 27793 4474
## BAFF R / TNFRSF13C 5335 9853 6160 12202 8661
## BCMA / TNFRSF17 82 0 589 0 0
## beta-Catenin 1 0 0 0 0
## BLC 1656 1365 0 0 1492
## BTC (Betacellulin) 4912 21513 813 2269 4777
## Cardiotrophin-1 8647 7456 9674 13767 14116
## IL-1ra 9836 17008 19596 25104 13008
## CCL28 14780 20114 23334 2907 35588
## CCL4 / MIP-1 beta 5564 15148 27519 1659 9932
## CCL7 / MCP-3 / MARC 0 4923 1089 1 552
## CCL8 / MCP-2 6707 25800 2812 1 4232
## CCR10 0 0 0 0 0
## CCR3 1 5330 1738 4200 132
## CCR4 7209 8110 10732 8381 6139
## CCR6 64787 6952 8127 2916 8167
## CCR7 694 3468 1413 404 3287
## CCR9 6102 7949 6249 5899 3469
## CD11b 1 1629 3270 5351 3781
## CD14 1 2153 1 2033 73
## CRP 22904 22094 20097 26664 16040
## CD27 / TNFRSF7 0 0 0 0 0
## CD27 Ligand / TNFSF7 1227 3414 4949 3921 3391
## CD30 0 1965 2227 1027 2840
## CD30 L 0 0 0 803 892
## CD40 1 1973 5815 0 862
## CD40 Ligand / TNFSF5 9235 32134 4533 16603 15745
## Cerberus 1 0 0 0 0 0
## Chordin-Like 2 0 0 0 0 0
## Coagulation Factor III / Tissue Factor 8146 13631 3719 5454 15842
## Common gamma Chain / IL-2 R gamma 8788 13158 28404 3752 13186
## CRG-2 2189 6439 16407 3134 4522
## Cripto 1 2092 1021 4357 926
## Crossveinless-2 7463 15199 6352 10540 10477
## Cryptic 0 4287 0 9776 3092
## Csk 2015 1712 8087 3503 6555
## CTACKÂ 89851 19499 21123 21952 22147
## CTLA-4 / CD152 2423 10525 7923 1 9988
## CXCL14 / BRAK 4327 15371 19882 2393 4784
## CXCL16 34475 15840 21752 19516 8575
## CXCR2 / IL-8 RB 3704 12910 7692 20806 3718
## CXCR3 1 6235 2589 10595 4158
## CXCR4 0 1 0 0 0
## CXCR6 258 11629 8579 1 11723
## EGF 1548 5007 0 1 2789
## Decorin 253433 11588 4153 16708 10040
## DKK-1 0 0 3 0 2076
## Dkk-3 3712 17788 2008 14517 5721
## Dkk-4 457 5043 1 0 1
## DPPIV / CD26 12211 17923 8822 14748 13412
## DR3 / TNFRSF25 122 1958 1 0 431
## Dtk 414233 1 38457 16429 57879
## EDAR 2909 9378 3489 1208 3929
## EGF R 1713 4091 7319 0 3250
## EG-VEGF / PK1 9017 12499 25271 2757 16734
## Endocan 2637 4004 23509 0 10421
## Endoglin / CD105 4533 12154 4428 400 3476
## Endostatin 15497 12295 79072 1414 24358
## Eotaxin 0 1 0 0 0
## Eotaxin-2 8115 13793 10920 10927 13173
## Epigen 962 4367 445 212 4137
## Epiregulin 12303 10043 5193 760 10975
## Erythropoietin (EPO) 2561 8360 2775 767 6289
## E-Selectin 2784 1 8073 3058 1
## FADD 11294 7012 9202 3576 7759
## FAM3B 0 193 6043 941 3134
## Fas / TNFRSF6 838607 1067975 949398 1303967 1132670
## Fas Ligand 1409 1023 1029 0 1921
## FCrRIIB / CD32b 11270 6777 3041 0 1832
## FGF R3 127862 1305 1007 1663 7003
## FGF R4 0 0 0 0 0
## FGF R5 beta 436 4469 1 0 450
## FGF-21 741 0 1 0 0
## Fit-3 Ligand 0 0 0 0 0
## FLRG (Follistatin) 4555 3107 1 0 891
## Follistatin-like 1 34079 16001 22754 6886 7732
## Fractalkine 465 6702 350 1 2346
## Frizzled-1 1 1557 1110 3110 4565
## Frizzled-6 14221 32872 36984 6371 22031
## Frizzled-7 5573 7603 2932 0 4622
## Galectin-3 3839 7077 5438 3681 6490
## G-CSF 1504 3414 4582 0 3993
## GDF-1 6653 4799 9731 6718 9191
## GDF-3 3640 12597 11029 0 3245
## GDF-5 14992 34804 24127 5968 16074
## GDF-8 13354 17818 47060 2725 18535
## GDF-9 0 0 0 0 0
## GFR alpha-2 / GDNF R alpha-2 0 440 1 1 0
## GFR alpha-3 / GDNF R alpha-3 0 0 1 0 1
## GFR alpha-4 / GDNF R alpha-4 47937 17568 10363 4930 8609
## GITR 1 14 1864 207 1881
## GITR Ligand / TNFSF18 1 3587 1 1260 4941
## Glut2 33102 32083 24275 1269 31247
## GM-CSF 4068 9382 4245 2738 5296
## Granzyme B 1767 6670 6034 7233 7260
## Granzyme D 0 1 116 0 1
## Granzyme G 235 1 715 0 1
## Gremlin 0 0 0 0 0
## Growth Hormone R 0 0 0 0 0
## HGF R 486 3890 1 1457 3594
## HGFÂ 0 0 0 0 0
## HVEM / TNFRSF14 2965 3821 15120 3488 8818
## ICAM-1 39426 80007 167512 16618 55889
## ICAM-2 / CD102 0 0 0 0 0
## ICAM-5 1 1043 0 0 1832
## ICK 3489 4499 900 5107 23600
## IFN-alpha / beta R1 0 0 0 908 0
## IFN-alpha / beta R2 1867 4959 711 2025 2828
## IFN-beta 0 0 1524 4669 73
## IFN-gamma 179 10985 2933 5151 1718
## IFN-gamma R1 5385 9796 27582 28735 12563
## IGFBP-1 4669 11188 42242 578 16243
## IGFBP-2 19448 8525 29495 2060 8626
## IGFBP-3 7224 21927 55401 1858 14234
## IGFBP-5 4190 6232 3133 4983 5278
## IGFBP-6 0 0 0 0 0
## IGFBP-L1 0 0 0 0 0
## IGF-I 5371 10301 8790 8273 13978
## IGF-II 3079 12821 14547 1 10171
## IL-1 alpha 110978 67312 45429 2175 18438
## IL-1 beta 0 0 1 0 319
## IL-1 R4 / ST2 62036 184243 61485 65276 64470
## IL-1 R6 / IL-1 R rp2 0 1 2941 665 1708
## IL-1 R9 0 0 1 0 0
## IL-1 RI 5237 19470 47672 1 14978
## IL-1 RII 9392 16586 11385 30899 14236
## IL-2 0 0 0 0 0
## IL-2 R alpha 4912 5687 2256 0 3092
## IL-2 R beta 1 2460 432 1 1076
## IL-3 371 128 1684 4360 851
## IL-3 R alpha 511 4062 18385 1 9975
## IL-3 R beta 612 5500 9027 1623 7645
## IL-4 0 0 2268 1 5107
## IL-4 R 0 1 1892 0 1786
## IL-5 1268 2270 4492 10634 4101
## IL-5 R alpha 0 439 0 1869 345
## IL-6 0 1 455 3917 1
## IL-6 R 0 0 0 0 1
## IL-7 0 0 0 0 0
## IL-7 R alpha 345 0 1 0 59
## IL-9 656694 13725 105056 26353 81202
## IL-9 R 15738 37591 21956 10554 32814
## IL-10 1174 951 4247 7375 2879
## IL-10 R alpha 20248 0 0 0 0
## IL-11 25608 88389 55256 5763 42784
## IL-12 p40/p70 1 1618 2032 6886 2670
## IL-12 p70 1750 5667 5225 7067 3947
## IL-12 R beta 1 0 0 1 0 0
## IL-13 2713 9929 1 0 4747
## IL-13 R alpha 2 4580 9779 1 0 4680
## IL-15 4429 11713 0 0 5651
## IL-15 R alpha 2059 11052 16500 1 14955
## IL-16 6329 39305 55740 6124 71172
## IL-17 2140 4591 5095 5880 4272
## IL-17BR 28966 5060 5067 0 7747
## IL-17C 0 0 0 0 0
## IL-17D 0 0 0 0 1
## IL-17E 2065 12100 0 1 9389
## IL-17F 0 0 1 0 0
## IL-17R 9862 45533 22165 1 21200
## IL-17RC 1 1922 3521 1950 3561
## IL-17RD 40855 6019 3432 174 5764
## IL-18 R alpha/IL-1 R5 6614 5939 3431 0 4757
## IL-20 3310 9603 4930 1 7537
## IL-20 R alpha 1211 0 2263 464 1108
## IL-21 0 0 1 0 0
## IL-21 R 127 1 1509 0 4181
## IL-22 63867 8540 3592 1 7184
## IL-22BP 0 0 0 0 0
## IL-23 0 0 0 0 0
## IL-23 R 29044 120822 56041 419 92103
## IL-24 0 0 1 0 2069
## IL-27 17091 83254 47984 3500 35541
## IL-28 / IFN-lambda 6908 79443 45835 2842 36698
## IL-31 0 19261 6321 0 3332
## IL-31 RA 0 0 1 0 0
## Insulin 218 1353 32 0 3048
## Integrin beta 2 / CD18 3230 6268 1541 0 4289
## I-TAC 0 0 1 0 0
## KC 3785 8155 3241 1 7421
## Kremen-1 0 4530 591 0 5323
## Kremen-2 0 0 362 1487 0
## Lefty-1 2035 9075 4363 1 4961
## Leptin R 0 3354 0 0 7526
## LEPTIN(OB) 0 0 0 0 0
## LIF 9052 6582 7177 1 11145
## LIGHT / TNFSF14 0 0 0 0 306
## LIX 1138 55777 30025 1 21816
## LRP-6 0 6860 8092 1 3165
## L-Selectin 33401 11625 10975 4407 12715
## Lungkine 3452 3710 11123 0 1080
## Lymphotactin 1 3383 1 1 1403
## Lymphotoxin beta R / TNFRSF3 5037 69033 110430 1396 88204
## MAdCAM-1 1228 1651 4883 0 1536
## MCP-1 1 0 0 551 0
## MCP-5 1 5875 2856 16368 12786
## M-CSF 2553 38063 31267 0 44323
## MDC 19776 35376 24953 32114 28092
## MFG-E8 2674 8823 0 0 5431
## MFRP 7330 1 6790 10304 20613
## MIG 0 0 1200 0 1
## MIP-1 alpha 0 3046 0 0 623
## MIP-1 gamma 4890 1642 1674 1 2658
## MIP-2 191334 7088 14935 1373 6792
## MIP-3 alpha 1526 1 90 1 1
## MIP-3 beta 1617 7105 1456 0 3470
## MMP-2 3575 2686 4373 3478 5155
## MMP-3 2332 16464 7905 1 9035
## MMP-9 812 1 1 1 1
## MMP-12 0 0 0 0 0
## MMP-14 / LEM-2 0 0 0 0 0
## MMP-24 / MT5-MMP 1 2443 1499 0 4586
## Neuregulin-3 / NRG3 0 0 1 0 168
## Neurturin 1 0 1 0 362
## NGF R / TNFRSF16 0 0 1031 0 1311
## NOV / CCN3 1862 10161 3897 3251 2549
## Osteoactivin / GPNMB 234 10927 9406 413 4873
## Osteopontin 10391 9850 13317 12243 15580
## Osteoporotegerin 13338 20910 8327 1996 11690
## OX40 Ligand / TNFSF4 1376 8105 2149 17059 3711
## PDGF C 4274 1406 5703 0 2678
## PDGF R alpha 1 5334 1 1 2789
## PDGF R beta 2073 6836 4832 0 3807
## Pentraxin3 / TSG-14 3890 15862 29600 0 27916
## PF-4 12506 6997 21837 0 26450
## PlGF-2 3848 19114 2869 11474 10752
## Progranulin 18530 20175 18436 19321 24406
## Prolactin 5394 33460 39430 4058 39417
## P-Selectin 1 27 7968 0 5964
## RAGE 6809 18417 3501 3199 7575
## RANTES 4550 6792 9368 6323 6198
## RELM beta 75299 19907 34976 29751 212614
## Resistin 0 1 694 2102 248
## S100A10 0 1 0 1254 1
## SCF 0 1 576 0 0
## SCF R / c-kit 35413 9588 5804 3573 6274
## SDF-1 1 1 5467 0 2464
## Serum Amyloid A1 0 1 0 1 3604
## Shh-N 7222 25657 9079 2588 10766
## SIGIRR 1647 1178 3404 1 5924
## SLPI 4796 1 0 0 160
## Soggy-1 4203 19633 27949 1192 29222
## SPARC 7021 63519 52920 3209 39701
## Spinesin Ectodomain 0 3110 6910 1 187
## TACI / TNFRSF13B 397 8169 3837 5786 3368
## TARC 8604 31593 4258 439 8067
## TCA-3 6795 28883 19032 63894 13624
## TCCR / WSX-1 2600 13531 23681 167 24114
## TECK 1070 7152 0 2695 5112
## TFPI 453 1 0 1 1259
## TGF-beta 1 392 3929 6856 1303 1768
## TGF-beta 2 0 0 0 0 0
## TGF-beta 3 0 3952 16748 5623 8807
## TGF-beta RI / ALK-5 0 3330 0 0 1632
## TGF-beta RII 13998 45308 115193 5398 99028
## Thrombospondin 2665 0 1 0 0
## Thymus Chemokine-1 87690 16396 3940 1692 4854
## Tie-2 0 0 1681 1 1479
## TIMP-1Â 1 1371 2302 2355 3024
## TIMP-2 6862 36016 45432 8393 13997
## TIMP-4 136 856 11653 0 260
## TL1A / TNFSF15 104 32 274 0 1845
## TLR1 0 0 0 0 1
## TLR2 4355 53608 110977 352 88573
## TLR3 0 684 0 0 1
## TLR4 1472 6735 4667 5365 4466
## TMEFF1 / Tomoregulin-1 0 0 1 0 0
## TNF RI / TNFRSF1A 805 0 0 400 0
## TNF RII 0 0 0 1128 1925
## TNF-alpha 0 0 0 0 1
## TNF-beta / TNFSF1B 762 15151 16217 2855 26388
## TPO 290 5990 4177 2312 3486
## TRAIL / TNFSF10 259819 5486 24694 11238 30979
## TRAIL R2 / TNFRSF10B 4544 12694 2353 1826 2409
## TRANCE / TNFSF11 7019 9113 3682 0 4585
## TREM-1 0 0 1201 0 1
## TROY 0 0 84 0 0
## TSLP 3524 8776 8106 0 11624
## TSLP R 2211 9318 17755 0 40934
## TWEAK / TNFSF12 2462 8537 4024 2307 10647
## TWEAK R / TNFRSF12 1 6161 22471 0 1
## Ubiqultin 0 0 0 1 0
## uPAR 1052 5565 2189 1 6047
## Urokinase 0 13676 23014 0 18633
## VCAM-1 9180 9730 10531 11103 17482
## VE-Cadherin 202306 9391 8209 54 14003
## VEGF 0 0 982 866 975
## VEGF R1 0 0 0 0 0
## VEGF R2 5786 15211 5193 11727 4281
## VEGF R3 1 5059 465 1 5444
## VEGF-B 4029 27340 23672 1 17503
## VEGFC 5852 55003 56691 556 64126
## VEGF-D 6796 1 1 0 3186
## WIF-1 0 1 0 0 3050
## WISP-1 / CCN4 14118 8359 15669 0 68375
## Aged+NaB Aged+NaB Aged+NaB Aged+NaB
## POS-Ave 120414 120414 120414 120414
## Neg-Ave 0 0 0 0
## 6Ckine 0 0 0 0
## Activin AÂ 93426 7081 0 1908
## Activin C 0 0 0 0
## Activin RIB / ALK-4 0 0 130 4388
## Adiponectin / Acrp30 0 3672 1 2415
## AgRP 26962 0 0 86
## ALCAM 0 0 0 0
## Angiopoietin-like 2 18451 5991 0 8829
## Angiopoietin-like 3 5821 1 204 6247
## AR (Amphiregulin) 0 818 0 0
## Artemin 145448 22327 11344 17816
## Axl 290974 33088 11385 23371
## b FGF 82655 4748 4417 10303
## B7-1/CD80 69235 21824 3642 19543
## BAFF R / TNFRSF13C 6744 11161 10144 16123
## BCMA / TNFRSF17 1 1282 1 2777
## beta-Catenin 0 1 0 2540
## BLC 5356 2183 0 24245
## BTC (Betacellulin) 36699 18245 1901 15176
## Cardiotrophin-1 161044 33298 11566 28580
## IL-1ra 122602 36864 11863 15678
## CCL28 145389 5186 3818 19956
## CCL4 / MIP-1 beta 60356 18466 5035 21312
## CCL7 / MCP-3 / MARC 0 308 1 7072
## CCL8 / MCP-2 133539 22421 1171 18669
## CCR10 0 399 0 0
## CCR3 7821 17410 0 5083
## CCR4 1 8703 9713 5864
## CCR6 20246 15222 7475 9646
## CCR7 1 2290 1756 5062
## CCR9 24045 7351 5192 14150
## CD11b 3595 690 1323 2405
## CD14 0 1287 0 4679
## CRP 162787 4709 3780 13712
## CD27 / TNFRSF7 0 0 0 0
## CD27 Ligand / TNFSF7 53864 12998 8511 6033
## CD30 0 3718 8625 13556
## CD30 L 1 964 1 84
## CD40 50482 7062 1131 2217
## CD40 Ligand / TNFSF5 16603 40361 6270 13665
## Cerberus 1 0 0 0 0
## Chordin-Like 2 0 0 0 1
## Coagulation Factor III / Tissue Factor 3008 23974 3165 10972
## Common gamma Chain / IL-2 R gamma 96471 7204 4868 9291
## CRG-2 7345 4953 1965 8854
## Cripto 1 3213 5199 7917
## Crossveinless-2 6191 19472 6040 9728
## Cryptic 8871 2628 1 5121
## Csk 31530 14681 2104 6113
## CTACKÂ 359993 23738 10436 22322
## CTLA-4 / CD152 14665 4594 2522 6930
## CXCL14 / BRAK 102131 31577 2668 32059
## CXCL16 43743 14350 4164 17586
## CXCR2 / IL-8 RB 12666 3511 894 15460
## CXCR3 10973 3839 135 6965
## CXCR4 734 0 0 0
## CXCR6 112866 3770 1997 7990
## EGF 4341 5037 1453 6356
## Decorin 123194 64435 9609 9369
## DKK-1 6678 6546 0 9038
## Dkk-3 54937 20447 2072 18038
## Dkk-4 0 1811 1298 1846
## DPPIV / CD26 28524 14382 18398 37365
## DR3 / TNFRSF25 0 2058 1 186
## Dtk 243736 228695 69209 52308
## EDAR 30689 8178 1876 12392
## EGF R 119166 13532 1641 5181
## EG-VEGF / PK1 3082 9216 1978 9446
## Endocan 128329 2104 1 5515
## Endoglin / CD105 24060 11056 2198 14062
## Endostatin 156135 9017 6187 10858
## Eotaxin 0 0 0 1330
## Eotaxin-2 67060 25495 6935 12121
## Epigen 3958 1886 1 6029
## Epiregulin 31017 15112 5243 21956
## Erythropoietin (EPO) 40788 1 1 10386
## E-Selectin 87137 26269 6913 10224
## FADD 90645 16979 3871 5215
## FAM3B 0 2501 1723 9269
## Fas / TNFRSF6 520805 993852 1304559 1270493
## Fas Ligand 196764 21337 1581 1785
## FCrRIIB / CD32b 10635 5344 2755 16325
## FGF R3 15753 13549 1824 2334
## FGF R4 0 1006 0 567
## FGF R5 beta 19972 4387 0 9621
## FGF-21 55095 4125 0 1372
## Fit-3 Ligand 0 0 0 1016
## FLRG (Follistatin) 11363 3055 1 6473
## Follistatin-like 1 156666 5214 3118 13220
## Fractalkine 11378 12800 0 18949
## Frizzled-1 75124 18165 2430 5276
## Frizzled-6 63047 6125 3334 9131
## Frizzled-7 255946 37674 10887 15495
## Galectin-3 12344 9965 7862 11935
## G-CSF 119439 16608 3178 5462
## GDF-1 4906 5259 7714 9276
## GDF-3 24660 7296 142 13433
## GDF-5 103202 29593 2185 28713
## GDF-8 152600 6148 4861 19302
## GDF-9 0 0 0 534
## GFR alpha-2 / GDNF R alpha-2 0 1150 0 4644
## GFR alpha-3 / GDNF R alpha-3 0 841 1 4705
## GFR alpha-4 / GDNF R alpha-4 59782 16265 1208 19533
## GITR 68217 10284 1089 6542
## GITR Ligand / TNFSF18 0 8370 2122 6309
## Glut2 96126 4009 7147 9664
## GM-CSF 27517 7424 8940 13136
## Granzyme B 8379 8873 5164 6033
## Granzyme D 75778 8286 0 3335
## Granzyme G 0 1 0 3268
## Gremlin 0 0 0 2
## Growth Hormone R 0 0 0 2222
## HGF R 7553 4427 154 11287
## HGFÂ 0 0 0 1030
## HVEM / TNFRSF14 5088 6682 8212 13144
## ICAM-1 264390 28055 13431 21390
## ICAM-2 / CD102 0 838 0 4588
## ICAM-5 0 3705 1 3708
## ICK 0 1352 5461 2918
## IFN-alpha / beta R1 1 872 0 1341
## IFN-alpha / beta R2 9701 6292 1 8680
## IFN-beta 2124 187 0 333
## IFN-gamma 12 47 1 2447
## IFN-gamma R1 117979 6300 4648 7220
## IGFBP-1 105222 3553 226 6078
## IGFBP-2 72830 5416 3235 7336
## IGFBP-3 92723 5922 4157 7360
## IGFBP-5 0 10242 10665 13707
## IGFBP-6 0 0 0 0
## IGFBP-L1 0 1 0 854
## IGF-I 41889 13797 13868 13860
## IGF-II 0 8366 2350 10042
## IL-1 alpha 256470 9996 4494 26271
## IL-1 beta 78580 11088 178 1058
## IL-1 R4 / ST2 0 133724 48791 50860
## IL-1 R6 / IL-1 R rp2 1371 3507 1628 9957
## IL-1 R9 0 0 0 736
## IL-1 RI 70007 20 2628 4657
## IL-1 RII 43182 16341 8233 30784
## IL-2 0 1 0 5370
## IL-2 R alpha 3882 2963 2740 4711
## IL-2 R beta 2030 3618 1 8836
## IL-3 1 29 1 806
## IL-3 R alpha 74055 4699 2223 1537
## IL-3 R beta 8743 4779 1771 9153
## IL-4 97045 13557 0 432
## IL-4 R 1561 2737 1799 7063
## IL-5 8872 2714 4034 4051
## IL-5 R alpha 773 1115 1 3078
## IL-6 2787 1 0 409
## IL-6 R 0 1 0 2616
## IL-7 0 0 998 1
## IL-7 R alpha 0 4492 1 4396
## IL-9 234179 323218 215335 115421
## IL-9 R 71317 30118 9408 34713
## IL-10 6798 2252 1283 2260
## IL-10 R alpha 18745 0 0 1090
## IL-11 182955 8145 6327 22908
## IL-12 p40/p70 3757 1704 356 2188
## IL-12 p70 11764 3783 3430 4144
## IL-12 R beta 1 0 1 0 4425
## IL-13 74601 4003 1978 10997
## IL-13 R alpha 2 9939 4698 1 7219
## IL-15 19638 6711 1 12567
## IL-15 R alpha 78606 6152 83 4402
## IL-16 369592 5659 4523 11000
## IL-17 35510 4631 1050 4068
## IL-17BR 15598 8345 11596 12137
## IL-17C 0 0 0 1
## IL-17D 0 1 1 6390
## IL-17E 18219 8424 1891 10744
## IL-17F 0 888 1 1975
## IL-17R 116015 2590 2827 5937
## IL-17RC 1686 4853 4035 6857
## IL-17RD 9707 5578 10743 12627
## IL-18 R alpha/IL-1 R5 209627 44738 8663 13801
## IL-20 50525 5649 982 9086
## IL-20 R alpha 189221 15166 5488 3324
## IL-21 0 1564 1 1488
## IL-21 R 124810 15770 678 6136
## IL-22 32467 1 1213 11827
## IL-22BP 0 1 0 6464
## IL-23 0 0 0 1
## IL-23 R 271223 4259 2703 11824
## IL-24 0 1217 1 5202
## IL-27 210026 10623 16456 24910
## IL-28 / IFN-lambda 174509 5659 3309 8229
## IL-31 59328 1791 1 2557
## IL-31 RA 0 1 1 7165
## Insulin 1 1 1 3738
## Integrin beta 2 / CD18 55165 3543 1 7540
## I-TAC 0 0 0 3936
## KC 15215 7963 59 10195
## Kremen-1 6840 3345 1 5585
## Kremen-2 0 1138 275 4096
## Lefty-1 25950 9932 1440 31338
## Leptin R 4044 2024 1693 2750
## LEPTIN(OB) 0 1834 0 2911
## LIF 80830 6957 3637 5855
## LIGHT / TNFSF14 12228 1118 0 1478
## LIX 183659 1560 1682 3155
## LRP-6 75563 2778 989 3244
## L-Selectin 160255 39752 14759 34245
## Lungkine 28401 0 0 2339
## Lymphotactin 1 50302 0 5351
## Lymphotoxin beta R / TNFRSF3 222935 19908 6180 10775
## MAdCAM-1 112585 17100 3846 4836
## MCP-1 0 0 0 2212
## MCP-5 912 23721 7977 8210
## M-CSF 185723 1 36 6205
## MDC 53816 33186 9079 37787
## MFG-E8 15969 4623 0 4070
## MFRP 6445 21471 5562 7869
## MIG 0 0 0 2108
## MIP-1 alpha 10533 1623 0 2115
## MIP-1 gamma 217161 31933 4567 2156
## MIP-2 126261 5481 5952 8692
## MIP-3 alpha 119522 17112 2612 3395
## MIP-3 beta 14045 4624 1065 7309
## MMP-2 487 10920 11544 16949
## MMP-3 24568 8389 1412 14565
## MMP-9 0 919 2085 3575
## MMP-12 0 1 618 5228
## MMP-14 / LEM-2 1443 1 1 1
## MMP-24 / MT5-MMP 11062 2940 1 4283
## Neuregulin-3 / NRG3 0 961 0 3544
## Neurturin 0 2065 7 4964
## NGF R / TNFRSF16 0 1819 1 4316
## NOV / CCN3 11754 6037 1 9765
## Osteoactivin / GPNMB 52456 4519 514 3707
## Osteopontin 8830 39384 28469 41667
## Osteoporotegerin 72074 20814 4078 34380
## OX40 Ligand / TNFSF4 8494 282298 1 6304
## PDGF C 141882 24953 2793 21336
## PDGF R alpha 10105 2137 0 5637
## PDGF R beta 95676 18218 2604 6302
## Pentraxin3 / TSG-14 113361 1704 1029 6305
## PF-4 132551 3772 3593 4664
## PlGF-2 33524 17155 2068 22039
## Progranulin 19878 47099 43920 59769
## Prolactin 129635 9417 7806 17335
## P-Selectin 184174 5712 2781 6610
## RAGE 69358 29203 2154 26587
## RANTES 252160 35446 6794 9627
## RELM beta 40824 102732 183888 28015
## Resistin 22967 4586 1 2661
## S100A10 1 1 0 4196
## SCF 0 1 1 4284
## SCF R / c-kit 14786 6214 4935 14964
## SDF-1 45641 1119 1496 1228
## Serum Amyloid A1 30 16099 4275 20696
## Shh-N 57824 21104 3169 24949
## SIGIRR 95043 19420 3300 6229
## SLPI 1 1996 1 6461
## Soggy-1 145522 4689 1653 8583
## SPARC 128464 7818 3535 16486
## Spinesin Ectodomain 4956 2766 1 3243
## TACI / TNFRSF13B 13249 5441 2356 9130
## TARC 60148 21354 1599 25332
## TCA-3 221575 24215 17335 7775
## TCCR / WSX-1 124203 3504 2901 4703
## TECK 4420 4638 718 7555
## TFPI 0 2228 2143 5341
## TGF-beta 1 1 369 868 4699
## TGF-beta 2 0 0 0 0
## TGF-beta 3 1 8113 6898 7591
## TGF-beta RI / ALK-5 7170 1460 1 7074
## TGF-beta RII 146665 10371 7094 19644
## Thrombospondin 0 3663 4210 13
## Thymus Chemokine-1 69338 22999 5299 21890
## Tie-2 1 3070 413 10455
## TIMP-1Â 12467 4825 5124 5470
## TIMP-2 217751 9772 8556 11948
## TIMP-4 0 0 0 1
## TL1A / TNFSF15 50174 11123 3248 4241
## TLR1 0 1 0 1486
## TLR2 158457 5375 2514 13352
## TLR3 1 7235 1 3475
## TLR4 12712 3836 1992 8572
## TMEFF1 / Tomoregulin-1 0 1047 223 10984
## TNF RI / TNFRSF1A 92250 16106 1727 5353
## TNF RII 59440 2234 1925 6705
## TNF-alpha 9527 579 0 799
## TNF-beta / TNFSF1B 79104 2978 1988 6296
## TPO 12234 4374 1627 8794
## TRAIL / TNFSF10 101752 150278 28420 26297
## TRAIL R2 / TNFRSF10B 26771 9998 9278 11284
## TRANCE / TNFSF11 9780 8147 275 11422
## TREM-1 24091 1 0 7138
## TROY 0 1983 1609 3774
## TSLP 17663 6835 6221 14854
## TSLP R 54459 4320 3895 8125
## TWEAK / TNFSF12 21035 5879 2237 13843
## TWEAK R / TNFRSF12 83793 734 11 6088
## Ubiqultin 13681 0 0 2460
## uPAR 9129 5052 2814 12062
## Urokinase 16077 1 0 3337
## VCAM-1 16911 15716 18181 21994
## VE-Cadherin 145665 19278 3786 4068
## VEGF 863 1640 875 5359
## VEGF R1 0 1 0 3949
## VEGF R2 46430 9361 1 1
## VEGF R3 6744 8551 1 4491
## VEGF-B 88712 5019 2654 11530
## VEGFC 29124 7519 2848 10006
## VEGF-D 139 3355 2016 4654
## WIF-1 1 1 0 4020
## WISP-1 / CCN4 115138 0 63355 4376
## Aged+NaB Aged+Combo Aged+Combo
## POS-Ave 120414 120414 120414
## Neg-Ave 0 0 0
## 6Ckine 728 2003 1
## Activin AÂ 9512 4679 1883
## Activin C 0 0 0
## Activin RIB / ALK-4 1 0 0
## Adiponectin / Acrp30 2768 5124 2468
## AgRP 13615 21584 13838
## ALCAM 260 0 0
## Angiopoietin-like 2 27364 6618 5158
## Angiopoietin-like 3 5312 8733 1
## AR (Amphiregulin) 0 0 277
## Artemin 14756 22388 9703
## Axl 13220 23418 3824
## b FGF 82922 44419 13097
## B7-1/CD80 22100 7551 5254
## BAFF R / TNFRSF13C 19789 9565 9367
## BCMA / TNFRSF17 11482 2727 1
## beta-Catenin 900 246 275
## BLC 8711 25143 7705
## BTC (Betacellulin) 20818 8360 6640
## Cardiotrophin-1 29205 49578 12149
## IL-1ra 63114 66872 17477
## CCL28 48358 90782 25672
## CCL4 / MIP-1 beta 54248 26781 20304
## CCL7 / MCP-3 / MARC 1 1 1721
## CCL8 / MCP-2 18995 11730 2912
## CCR10 0 244 0
## CCR3 11505 3462 1808
## CCR4 13151 16532 7816
## CCR6 31510 40270 18761
## CCR7 6705 4079 2207
## CCR9 8163 5220 13786
## CD11b 8116 4758 3755
## CD14 5141 4107 3571
## CRP 38635 25992 75213
## CD27 / TNFRSF7 0 277 0
## CD27 Ligand / TNFSF7 5218 12564 5716
## CD30 5243 38176 2786
## CD30 L 1 208 4370
## CD40 2548 3552 2051
## CD40 Ligand / TNFSF5 10837 4840 6301
## Cerberus 1 0 0 0
## Chordin-Like 2 487 973 0
## Coagulation Factor III / Tissue Factor 2549 3781 18145
## Common gamma Chain / IL-2 R gamma 28546 54215 14031
## CRG-2 11064 6476 6972
## Cripto 8276 20962 3985
## Crossveinless-2 5539 7167 27183
## Cryptic 6677 3106 2250
## Csk 5312 5585 9862
## CTACKÂ 46765 68917 116682
## CTLA-4 / CD152 15672 6051 7574
## CXCL14 / BRAK 11946 9751 12513
## CXCL16 19520 33761 18184
## CXCR2 / IL-8 RB 11974 4958 4277
## CXCR3 11308 5294 5189
## CXCR4 1865 1022 0
## CXCR6 18405 9889 8168
## EGF 6126 5481 6346
## Decorin 26472 156466 91679
## DKK-1 2115 2996 2899
## Dkk-3 14462 6524 6313
## Dkk-4 69 1431 1
## DPPIV / CD26 21028 56586 13339
## DR3 / TNFRSF25 1 1241 1102
## Dtk 80607 319097 203794
## EDAR 11267 7523 6240
## EGF R 8822 5448 5371
## EG-VEGF / PK1 29400 62119 9056
## Endocan 23965 10097 6675
## Endoglin / CD105 14359 6870 5129
## Endostatin 76635 34320 13137
## Eotaxin 1332 769 2
## Eotaxin-2 18413 12905 11878
## Epigen 5152 4072 3953
## Epiregulin 14499 9682 17722
## Erythropoietin (EPO) 6849 4635 4531
## E-Selectin 6238 8634 12230
## FADD 9259 9027 8237
## FAM3B 2879 4097 3932
## Fas / TNFRSF6 669672 521386 968128
## Fas Ligand 2168 3191 7107
## FCrRIIB / CD32b 9128 20351 6539
## FGF R3 9750 54665 22720
## FGF R4 1104 1001 1
## FGF R5 beta 10054 5165 3965
## FGF-21 1943 1499 991
## Fit-3 Ligand 0 280 1
## FLRG (Follistatin) 15128 13610 2986
## Follistatin-like 1 81389 146689 24716
## Fractalkine 5169 3409 2809
## Frizzled-1 1 3787 7930
## Frizzled-6 13405 23874 19344
## Frizzled-7 6653 7018 7267
## Galectin-3 11987 9187 10103
## G-CSF 8964 5695 3939
## GDF-1 5621 7213 8459
## GDF-3 13418 5675 4306
## GDF-5 35252 13252 12457
## GDF-8 62816 23818 11463
## GDF-9 319 840 1
## GFR alpha-2 / GDNF R alpha-2 2177 3246 2709
## GFR alpha-3 / GDNF R alpha-3 2274 2726 2039
## GFR alpha-4 / GDNF R alpha-4 65766 118069 28215
## GITR 3679 5147 5526
## GITR Ligand / TNFSF18 1813 3149 6210
## Glut2 21850 23361 21427
## GM-CSF 10337 6173 7125
## Granzyme B 9220 8148 4981
## Granzyme D 2582 4489 2571
## Granzyme G 2205 1901 98
## Gremlin 0 280 0
## Growth Hormone R 831 1088 1
## HGF R 9204 8739 5500
## HGFÂ 1117 1250 1349
## HVEM / TNFRSF14 9401 8419 8865
## ICAM-1 43991 126323 45100
## ICAM-2 / CD102 1071 2088 1952
## ICAM-5 3362 3776 3435
## ICK 1032 7707 1
## IFN-alpha / beta R1 0 1863 809
## IFN-alpha / beta R2 9484 11517 3340
## IFN-beta 13 849 764
## IFN-gamma 5312 3770 2112
## IFN-gamma R1 47630 23159 6640
## IGFBP-1 35135 18366 8866
## IGFBP-2 23855 35463 10448
## IGFBP-3 35550 29653 11916
## IGFBP-5 6735 8260 6746
## IGFBP-6 0 0 1
## IGFBP-L1 1 1127 883
## IGF-I 9828 15609 15149
## IGF-II 10922 11511 9188
## IL-1 alpha 28080 228360 115653
## IL-1 beta 1 4141 4892
## IL-1 R4 / ST2 75831 86499 73955
## IL-1 R6 / IL-1 R rp2 1840 2706 2478
## IL-1 R9 143 651 1
## IL-1 RI 77618 21300 6362
## IL-1 RII 24537 12514 9488
## IL-2 1472 2055 0
## IL-2 R alpha 9937 3620 1936
## IL-2 R beta 5042 4958 2904
## IL-3 3816 1730 2658
## IL-3 R alpha 7597 11871 7248
## IL-3 R beta 9810 14700 8459
## IL-4 598 2875 2482
## IL-4 R 3429 3765 3841
## IL-5 7095 3738 3754
## IL-5 R alpha 1516 2509 1759
## IL-6 117 684 574
## IL-6 R 1321 1413 1
## IL-7 0 735 1
## IL-7 R alpha 1096 2485 1644
## IL-9 302480 521284 514190
## IL-9 R 83868 26830 19657
## IL-10 3991 3866 4288
## IL-10 R alpha 0 41903 3249
## IL-11 66048 60757 41712
## IL-12 p40/p70 4217 2956 3584
## IL-12 p70 8053 5264 3300
## IL-12 R beta 1 835 1804 345
## IL-13 12962 2185 6603
## IL-13 R alpha 2 8987 4056 2951
## IL-15 10664 3343 2423
## IL-15 R alpha 20482 18944 5177
## IL-16 30392 63443 18144
## IL-17 11155 7913 4969
## IL-17BR 8595 116056 29240
## IL-17C 0 55 1
## IL-17D 2510 2670 1876
## IL-17E 8057 5131 5361
## IL-17F 0 965 739
## IL-17R 31931 26070 20197
## IL-17RC 1914 2479 3666
## IL-17RD 12313 136835 18410
## IL-18 R alpha/IL-1 R5 8842 5164 5014
## IL-20 15340 4333 9065
## IL-20 R alpha 6187 4686 5018
## IL-21 27 1538 1
## IL-21 R 4582 6282 4179
## IL-22 11569 111206 42832
## IL-22BP 2583 1836 1639
## IL-23 0 310 162
## IL-23 R 55979 45884 42991
## IL-24 1884 2243 934
## IL-27 54568 50716 41586
## IL-28 / IFN-lambda 53478 33170 28377
## IL-31 11923 9146 6423
## IL-31 RA 2035 1514 485
## Insulin 5154 2514 1
## Integrin beta 2 / CD18 6842 3536 2553
## I-TAC 650 619 108
## KC 9891 3674 7126
## Kremen-1 5497 4356 260
## Kremen-2 1708 2542 2141
## Lefty-1 12091 6235 4798
## Leptin R 4532 2791 1208
## LEPTIN(OB) 159 881 349
## LIF 7521 64158 21466
## LIGHT / TNFSF14 1237 270 1
## LIX 32911 21326 18799
## LRP-6 7785 6250 4040
## L-Selectin 16139 23196 6728
## Lungkine 21798 8244 2642
## Lymphotactin 5934 4216 1002
## Lymphotoxin beta R / TNFRSF3 101663 47502 20597
## MAdCAM-1 5307 18507 7545
## MCP-1 769 1288 565
## MCP-5 11973 12606 6601
## M-CSF 17219 17725 4368
## MDC 13549 10005 12508
## MFG-E8 8869 3488 1991
## MFRP 5333 7584 21232
## MIG 183 952 1
## MIP-1 alpha 4414 2660 841
## MIP-1 gamma 2907 4352 2358
## MIP-2 17926 7683 2151
## MIP-3 alpha 2091 3356 565
## MIP-3 beta 7745 3421 792
## MMP-2 7424 6499 7114
## MMP-3 16282 6923 3602
## MMP-9 1703 2793 1
## MMP-12 1942 1979 1342
## MMP-14 / LEM-2 1 1318 0
## MMP-24 / MT5-MMP 4640 3607 3538
## Neuregulin-3 / NRG3 1095 1890 1485
## Neurturin 1862 2820 1421
## NGF R / TNFRSF16 1868 1908 1767
## NOV / CCN3 8439 4106 3186
## Osteoactivin / GPNMB 18086 24612 11439
## Osteopontin 25457 17575 29324
## Osteoporotegerin 29642 7441 4571
## OX40 Ligand / TNFSF4 10797 4784 2425
## PDGF C 8001 5735 1859
## PDGF R alpha 8135 3519 1421
## PDGF R beta 11832 6623 5646
## Pentraxin3 / TSG-14 17751 18930 5048
## PF-4 1 37818 7775
## PlGF-2 17939 5963 3128
## Progranulin 41244 21569 23837
## Prolactin 49239 45827 28190
## P-Selectin 11481 22181 6135
## RAGE 9988 8734 3404
## RANTES 9802 10823 7558
## RELM beta 54409 111990 53849
## Resistin 2730 3568 3373
## S100A10 4361 2408 0
## SCF 1 1293 406
## SCF R / c-kit 13503 41283 9347
## SDF-1 4375 5620 9372
## Serum Amyloid A1 5570 7651 12303
## Shh-N 23590 9914 6713
## SIGIRR 5120 8367 4082
## SLPI 0 8274 1337
## Soggy-1 38480 33145 16499
## SPARC 72057 47787 32847
## Spinesin Ectodomain 3891 2745 446
## TACI / TNFRSF13B 9680 4949 4160
## TARC 25671 7060 2985
## TCA-3 43454 34613 8643
## TCCR / WSX-1 26106 18937 3711
## TECK 9431 4860 3733
## TFPI 3302 2377 1
## TGF-beta 1 5568 4641 2657
## TGF-beta 2 0 0 0
## TGF-beta 3 10240 7759 912
## TGF-beta RI / ALK-5 4992 1692 220
## TGF-beta RII 68910 62272 42595
## Thrombospondin 0 2460 1
## Thymus Chemokine-1 20861 330492 80859
## Tie-2 2030 2045 1561
## TIMP-1Â 3034 3641 3995
## TIMP-2 34495 1 9756
## TIMP-4 7955 23 1437
## TL1A / TNFSF15 3982 14130 1
## TLR1 1863 1188 247
## TLR2 133587 34116 22148
## TLR3 4224 2020 1
## TLR4 9926 4574 3278
## TMEFF1 / Tomoregulin-1 2289 2988 1532
## TNF RI / TNFRSF1A 786 4268 543
## TNF RII 4258 5719 3405
## TNF-alpha 552 1694 1
## TNF-beta / TNFSF1B 29346 20595 26059
## TPO 9811 4532 2798
## TRAIL / TNFSF10 69657 278978 115151
## TRAIL R2 / TNFRSF10B 13667 4834 508
## TRANCE / TNFSF11 10129 8658 1585
## TREM-1 1944 2255 1
## TROY 126 1771 729
## TSLP 8107 3256 2768
## TSLP R 14698 12858 5264
## TWEAK / TNFSF12 14118 8173 4909
## TWEAK R / TNFRSF12 16936 13489 4416
## Ubiqultin 948 2175 1
## uPAR 7705 12974 2527
## Urokinase 29421 25869 17256
## VCAM-1 15205 24558 12100
## VE-Cadherin 31358 248050 115941
## VEGF 1206 1447 1180
## VEGF R1 562 650 0
## VEGF R2 12905 4674 0
## VEGF R3 7651 2933 193
## VEGF-B 27157 28568 6550
## VEGFC 50219 46527 14248
## VEGF-D 2538 13239 5685
## WIF-1 2202 5985 744
## WISP-1 / CCN4 11103 70449 10492
## Aged+Combo Aged+Combo Aged+Combo
## POS-Ave 120414 120414 120414
## Neg-Ave 0 0 0
## 6Ckine 0 0 0
## Activin AÂ 1 10503 2543
## Activin C 0 0 0
## Activin RIB / ALK-4 0 704 1
## Adiponectin / Acrp30 0 598 1
## AgRP 0 5971 4247
## ALCAM 0 0 0
## Angiopoietin-like 2 0 2582 3602
## Angiopoietin-like 3 0 73 3474
## AR (Amphiregulin) 0 0 0
## Artemin 2797 7116 6066
## Axl 4239 7743 5253
## b FGF 10485 19799 33025
## B7-1/CD80 3352 5383 10202
## BAFF R / TNFRSF13C 5591 5187 6118
## BCMA / TNFRSF17 60 2444 3073
## beta-Catenin 2473 327 1
## BLC 3597 33670 2553
## BTC (Betacellulin) 8257 14506 5951
## Cardiotrophin-1 7422 45610 10585
## IL-1ra 9453 68995 8948
## CCL28 10837 52595 10329
## CCL4 / MIP-1 beta 3610 17362 11388
## CCL7 / MCP-3 / MARC 0 1162 1
## CCL8 / MCP-2 1222 8859 23531
## CCR10 0 0 0
## CCR3 0 1992 2579
## CCR4 5677 12249 13333
## CCR6 32053 25539 7560
## CCR7 1666 5152 3386
## CCR9 5513 8117 2213
## CD11b 0 524 1
## CD14 0 635 101
## CRP 8172 61652 10255
## CD27 / TNFRSF7 0 0 0
## CD27 Ligand / TNFSF7 611 4345 3603
## CD30 0 1764 2971
## CD30 L 0 80 1
## CD40 1 2216 1948
## CD40 Ligand / TNFSF5 10053 4706 5191
## Cerberus 1 0 0 0
## Chordin-Like 2 0 0 433
## Coagulation Factor III / Tissue Factor 18769 2331 10782
## Common gamma Chain / IL-2 R gamma 7858 19738 17928
## CRG-2 889 7968 5383
## Cripto 1 1909 1399
## Crossveinless-2 12897 4130 5041
## Cryptic 0 1807 315
## Csk 795 5343 4665
## CTACKÂ 61721 100821 31918
## CTLA-4 / CD152 5200 5690 6732
## CXCL14 / BRAK 2919 7085 5807
## CXCL16 6319 31170 11631
## CXCR2 / IL-8 RB 3245 3636 3354
## CXCR3 1798 3753 3562
## CXCR4 706 706 0
## CXCR6 3155 11222 8027
## EGF 1347 5928 7241
## Decorin 37904 306314 120148
## DKK-1 0 9438 650
## Dkk-3 2630 15303 9981
## Dkk-4 0 0 0
## DPPIV / CD26 6058 10396 8632
## DR3 / TNFRSF25 1 0 0
## Dtk 362303 483059 408002
## EDAR 1451 3661 5710
## EGF R 1391 5253 3808
## EG-VEGF / PK1 7098 25964 21348
## Endocan 1 31237 7647
## Endoglin / CD105 2439 5325 5885
## Endostatin 11310 31842 27268
## Eotaxin 0 575 1
## Eotaxin-2 3478 12985 11295
## Epigen 0 2286 897
## Epiregulin 3044 10448 16406
## Erythropoietin (EPO) 0 2960 3386
## E-Selectin 1 4771 10051
## FADD 4259 23804 4559
## FAM3B 1 645 1831
## Fas / TNFRSF6 1059150 521094 652228
## Fas Ligand 1 3419 1950
## FCrRIIB / CD32b 1846 15643 9301
## FGF R3 6145 13778 10172
## FGF R4 0 1233 1
## FGF R5 beta 359 3802 3860
## FGF-21 0 2430 583
## Fit-3 Ligand 0 0 0
## FLRG (Follistatin) 1 9246 7402
## Follistatin-like 1 52964 155884 129641
## Fractalkine 0 3321 4125
## Frizzled-1 0 9079 4282
## Frizzled-6 12186 85861 35321
## Frizzled-7 16678 90399 3971
## Galectin-3 815 5109 5329
## G-CSF 1 4846 3644
## GDF-1 1 1617 1888
## GDF-3 970 5773 6406
## GDF-5 4965 23152 19256
## GDF-8 1737 22557 10384
## GDF-9 0 1 0
## GFR alpha-2 / GDNF R alpha-2 0 1884 1
## GFR alpha-3 / GDNF R alpha-3 0 794 1
## GFR alpha-4 / GDNF R alpha-4 21882 74226 90720
## GITR 1 4029 3162
## GITR Ligand / TNFSF18 0 1 1
## Glut2 38715 116234 13490
## GM-CSF 1 2572 3494
## Granzyme B 1171 3418 4536
## Granzyme D 1067 3755 4819
## Granzyme G 0 265 692
## Gremlin 0 0 0
## Growth Hormone R 0 540 1278
## HGF R 1 3130 3266
## HGFÂ 0 710 0
## HVEM / TNFRSF14 2122 6803 6672
## ICAM-1 30691 118819 126233
## ICAM-2 / CD102 0 73 0
## ICAM-5 0 983 0
## ICK 0 2072 7739
## IFN-alpha / beta R1 0 0 0
## IFN-alpha / beta R2 0 336 328
## IFN-beta 0 0 0
## IFN-gamma 0 1 1
## IFN-gamma R1 7543 101406 60552
## IGFBP-1 4567 27875 6611
## IGFBP-2 5411 18141 6241
## IGFBP-3 6952 36363 21407
## IGFBP-5 1265 5348 8603
## IGFBP-6 0 0 0
## IGFBP-L1 0 0 0
## IGF-I 12166 14423 14090
## IGF-II 1875 11494 19327
## IL-1 alpha 37793 276888 194687
## IL-1 beta 0 1 1
## IL-1 R4 / ST2 154011 167509 69766
## IL-1 R6 / IL-1 R rp2 0 1645 1346
## IL-1 R9 0 0 1
## IL-1 RI 2286 14981 21521
## IL-1 RII 1229 9662 7081
## IL-2 0 1 1
## IL-2 R alpha 0 1741 7199
## IL-2 R beta 0 1939 1303
## IL-3 0 731 0
## IL-3 R alpha 5556 92242 12834
## IL-3 R beta 0 1945 614
## IL-4 0 9531 1644
## IL-4 R 0 2292 2410
## IL-5 0 1 189
## IL-5 R alpha 0 1 1
## IL-6 0 0 0
## IL-6 R 0 723 334
## IL-7 0 1 88
## IL-7 R alpha 0 1752 463
## IL-9 604921 421595 397006
## IL-9 R 14735 65680 25992
## IL-10 0 1 414
## IL-10 R alpha 0 52123 4025
## IL-11 6207 124719 15572
## IL-12 p40/p70 0 1 0
## IL-12 p70 582 6100 1
## IL-12 R beta 1 0 973 1327
## IL-13 1 4007 10169
## IL-13 R alpha 2 0 3888 7591
## IL-15 0 4345 3693
## IL-15 R alpha 3322 18086 7748
## IL-16 9990 45792 18214
## IL-17 0 2504 376
## IL-17BR 17284 22436 14800
## IL-17C 0 0 0
## IL-17D 0 1758 1
## IL-17E 0 5589 2626
## IL-17F 0 0 0
## IL-17R 8397 42916 4011
## IL-17RC 2746 2089 2112
## IL-17RD 34816 12020 18749
## IL-18 R alpha/IL-1 R5 45 6665 5420
## IL-20 0 11336 5195
## IL-20 R alpha 0 11164 3752
## IL-21 0 1 995
## IL-21 R 0 8019 3322
## IL-22 8780 97486 15717
## IL-22BP 0 1224 84
## IL-23 0 1 0
## IL-23 R 32339 111266 29592
## IL-24 0 4118 0
## IL-27 8746 20385 13511
## IL-28 / IFN-lambda 13444 17004 19565
## IL-31 286 4662 7075
## IL-31 RA 0 894 778
## Insulin 0 1496 2047
## Integrin beta 2 / CD18 0 2335 3163
## I-TAC 0 19 1
## KC 0 2683 4679
## Kremen-1 0 3378 3193
## Kremen-2 0 2061 1369
## Lefty-1 1 3674 5700
## Leptin R 0 1109 1412
## LEPTIN(OB) 0 0 0
## LIF 12912 90783 22392
## LIGHT / TNFSF14 0 124 1
## LIX 16765 19649 18164
## LRP-6 0 1 2949
## L-Selectin 8360 36902 15762
## Lungkine 0 6336 3419
## Lymphotactin 0 2300 3815
## Lymphotoxin beta R / TNFRSF3 25060 45614 53517
## MAdCAM-1 1058 5681 3785
## MCP-1 0 1 1
## MCP-5 3319 6318 7967
## M-CSF 17217 13893 12377
## MDC 28532 23406 19531
## MFG-E8 0 374 4365
## MFRP 1 2039 7726
## MIG 0 1 0
## MIP-1 alpha 0 1062 1
## MIP-1 gamma 739 3676 2148
## MIP-2 28570 21451 13621
## MIP-3 alpha 1 3604 1312
## MIP-3 beta 0 5447 4981
## MMP-2 3671 8623 11258
## MMP-3 466 7464 14321
## MMP-9 1 1455 183
## MMP-12 0 1680 549
## MMP-14 / LEM-2 1 1 0
## MMP-24 / MT5-MMP 0 1490 1694
## Neuregulin-3 / NRG3 0 502 1613
## Neurturin 0 932 758
## NGF R / TNFRSF16 0 941 154
## NOV / CCN3 1 2148 2302
## Osteoactivin / GPNMB 1842 5423 2866
## Osteopontin 23338 21854 40019
## Osteoporotegerin 2818 11122 13376
## OX40 Ligand / TNFSF4 0 3603 3513
## PDGF C 1 9828 3500
## PDGF R alpha 0 1981 1968
## PDGF R beta 1568 7449 6833
## Pentraxin3 / TSG-14 5087 16293 14142
## PF-4 3328 32232 14711
## PlGF-2 123 4273 8441
## Progranulin 32089 29506 39285
## Prolactin 34637 18537 36284
## P-Selectin 0 12979 4836
## RAGE 147 4787 6047
## RANTES 4037 9717 6047
## RELM beta 22749 11902 29438
## Resistin 0 4934 3776
## S100A10 0 1840 485
## SCF 0 888 1
## SCF R / c-kit 2297 42997 20147
## SDF-1 0 6629 3311
## Serum Amyloid A1 6416 10814 11965
## Shh-N 1580 7882 10974
## SIGIRR 1251 6833 4478
## SLPI 1 10446 63370
## Soggy-1 2205 12408 22370
## SPARC 8671 20118 35517
## Spinesin Ectodomain 1 18 1
## TACI / TNFRSF13B 1 3814 7254
## TARC 2317 6850 11379
## TCA-3 5490 31550 38357
## TCCR / WSX-1 3017 17946 50341
## TECK 0 3174 4230
## TFPI 0 3 43
## TGF-beta 1 0 2792 3792
## TGF-beta 2 0 0 0
## TGF-beta 3 1 5098 2808
## TGF-beta RI / ALK-5 0 473 904
## TGF-beta RII 7709 35141 35350
## Thrombospondin 0 895 1
## Thymus Chemokine-1 55278 322404 240764
## Tie-2 0 1038 624
## TIMP-1Â 1345 2872 2325
## TIMP-2 8705 22737 16773
## TIMP-4 1 4729 2629
## TL1A / TNFSF15 397 3631 2837
## TLR1 0 883 1
## TLR2 23094 84305 63141
## TLR3 0 405 1
## TLR4 1 4065 3795
## TMEFF1 / Tomoregulin-1 0 2199 1374
## TNF RI / TNFRSF1A 0 3020 57
## TNF RII 0 4228 2765
## TNF-alpha 0 0 0
## TNF-beta / TNFSF1B 3292 17475 15248
## TPO 260 1958 2894
## TRAIL / TNFSF10 332311 317331 197936
## TRAIL R2 / TNFRSF10B 2134 4407 5822
## TRANCE / TNFSF11 920 10394 6665
## TREM-1 0 2202 907
## TROY 0 1376 2486
## TSLP 0 3917 6734
## TSLP R 4388 15747 18163
## TWEAK / TNFSF12 0 5268 5866
## TWEAK R / TNFRSF12 1971 11520 11521
## Ubiqultin 1 180 1
## uPAR 0 3547 2898
## Urokinase 646 10208 6967
## VCAM-1 6821 10951 22256
## VE-Cadherin 159303 270398 168156
## VEGF 0 173 1112
## VEGF R1 0 765 575
## VEGF R2 1259 4188 7379
## VEGF R3 0 2429 2773
## VEGF-B 9733 45686 37496
## VEGFC 19881 64577 54896
## VEGF-D 5538 30013 8007
## WIF-1 0 1074 2213
## WISP-1 / CCN4 23641 62923 32291
## Aged+IGF2 Aged+IGF2 Aged+IGF2 Aged+IGF2
## POS-Ave 120414 120414 120414 120414
## Neg-Ave 0 0 0 0
## 6Ckine 0 1 0 1
## Activin AÂ 0 2873 1112 809
## Activin C 0 0 0 0
## Activin RIB / ALK-4 7093 0 0 0
## Adiponectin / Acrp30 0 2377 598 0
## AgRP 0 5954 9855 7787
## ALCAM 0 0 0 0
## Angiopoietin-like 2 0 10625 7342 5814
## Angiopoietin-like 3 0 4833 2436 1075
## AR (Amphiregulin) 0 0 1 1
## Artemin 0 11716 7905 7327
## Axl 0 11631 7406 13276
## b FGF 0 26586 32317 24221
## B7-1/CD80 0 13286 5956 7431
## BAFF R / TNFRSF13C 0 10041 5755 8159
## BCMA / TNFRSF17 0 646 167 238
## beta-Catenin 0 1 0 0
## BLC 0 2930 4150 5648
## BTC (Betacellulin) 66559 12804 19416 7912
## Cardiotrophin-1 1 19955 16879 14180
## IL-1ra 1 21916 34701 27478
## CCL28 3641 92900 123105 71115
## CCL4 / MIP-1 beta 81 19359 14921 14433
## CCL7 / MCP-3 / MARC 1 162 7017 3513
## CCL8 / MCP-2 0 14027 6457 7973
## CCR10 0 1 0 0
## CCR3 0 6373 1827 5103
## CCR4 18706 16410 10175 10268
## CCR6 0 14171 15361 8088
## CCR7 0 4129 2502 2399
## CCR9 0 9291 5872 8507
## CD11b 0 8099 5843 6839
## CD14 0 2732 1454 117
## CRP 1 122142 111314 45872
## CD27 / TNFRSF7 5252 0 0 0
## CD27 Ligand / TNFSF7 102 9187 6114 4795
## CD30 0 6605 2640 7599
## CD30 L 0 1098 41 716
## CD40 0 4254 2731 2407
## CD40 Ligand / TNFSF5 6256 7979 7486 12189
## Cerberus 1 0 0 0 1
## Chordin-Like 2 0 296 0 540
## Coagulation Factor III / Tissue Factor 0 13541 14085 16771
## Common gamma Chain / IL-2 R gamma 0 39273 87874 92697
## CRG-2 0 10181 5985 5422
## Cripto 0 5413 3798 4266
## Crossveinless-2 17574 9836 10636 12199
## Cryptic 0 3871 835 117
## Csk 16947 11334 4657 7624
## CTACKÂ 11557 73333 61306 63876
## CTLA-4 / CD152 874 15122 16934 7990
## CXCL14 / BRAK 1 14372 28311 8670
## CXCL16 0 12472 5835 10576
## CXCR2 / IL-8 RB 0 7482 4753 5273
## CXCR3 0 7919 5988 4934
## CXCR4 0 1679 1 0
## CXCR6 0 16884 26064 12717
## EGF 0 9232 5662 4829
## Decorin 1 7978 4530 5182
## DKK-1 0 5933 3644 2578
## Dkk-3 0 16324 7313 9119
## Dkk-4 1 1 133 2
## DPPIV / CD26 1930 21055 8755 22594
## DR3 / TNFRSF25 237 606 28 799
## Dtk 246372 19916 12878 5644
## EDAR 1 9410 5489 5581
## EGF R 0 7975 6088 5397
## EG-VEGF / PK1 1079 16139 29100 10426
## Endocan 0 8941 24477 6345
## Endoglin / CD105 0 12583 6229 5759
## Endostatin 7717 34108 73120 38116
## Eotaxin 0 2427 1862 1751
## Eotaxin-2 0 23343 17388 13481
## Epigen 0 4510 3032 2724
## Epiregulin 17194 15281 5276 28133
## Erythropoietin (EPO) 0 10895 4263 4110
## E-Selectin 0 17265 7734 5168
## FADD 0 18009 8357 23482
## FAM3B 0 5530 3758 2668
## Fas / TNFRSF6 718673 687825 609045 785048
## Fas Ligand 0 4733 2230 2304
## FCrRIIB / CD32b 0 7444 3473 5357
## FGF R3 0 4256 1349 3137
## FGF R4 0 1717 0 0
## FGF R5 beta 0 13377 2505 4270
## FGF-21 0 3812 1746 3082
## Fit-3 Ligand 0 649 515 1334
## FLRG (Follistatin) 0 7515 2678 3060
## Follistatin-like 1 1 13936 22047 16273
## Fractalkine 0 6340 3691 15244
## Frizzled-1 0 7945 4622 3160
## Frizzled-6 2498 50510 40846 41067
## Frizzled-7 0 12100 8538 11062
## Galectin-3 1 9955 5416 16366
## G-CSF 0 7090 3489 4477
## GDF-1 0 4949 3305 11361
## GDF-3 0 10895 4284 7245
## GDF-5 0 28465 21060 18879
## GDF-8 1 23900 48837 49465
## GDF-9 0 412 1 0
## GFR alpha-2 / GDNF R alpha-2 0 4326 3053 1713
## GFR alpha-3 / GDNF R alpha-3 0 3328 2443 192
## GFR alpha-4 / GDNF R alpha-4 0 20275 11618 12701
## GITR 0 8005 4643 3314
## GITR Ligand / TNFSF18 0 6247 5572 7542
## Glut2 16996 46871 57452 82534
## GM-CSF 0 9173 5299 5714
## Granzyme B 0 8841 7102 7472
## Granzyme D 0 5231 2071 2053
## Granzyme G 0 2226 340 1493
## Gremlin 0 737 0 0
## Growth Hormone R 0 3396 0 1
## HGF R 0 11641 2199 8248
## HGFÂ 0 1310 1 643
## HVEM / TNFRSF14 0 13634 9754 10130
## ICAM-1 35874 57306 114627 132019
## ICAM-2 / CD102 0 2130 2013 1678
## ICAM-5 0 4931 2202 2264
## ICK 6749 9795 7028 0
## IFN-alpha / beta R1 0 1925 631 217
## IFN-alpha / beta R2 0 10729 3327 5847
## IFN-beta 0 1104 2138 9232
## IFN-gamma 0 6602 4118 5234
## IFN-gamma R1 0 26741 42986 8051
## IGFBP-1 0 19130 115157 10247
## IGFBP-2 0 18302 45205 11346
## IGFBP-3 1808 20662 59509 27426
## IGFBP-5 0 11576 7365 4273
## IGFBP-6 0 0 0 0
## IGFBP-L1 0 1 0 1
## IGF-I 7256 18563 29492 105624
## IGF-II 0 16499 7531 9677
## IL-1 alpha 7493 71420 77512 81733
## IL-1 beta 0 5387 3697 3635
## IL-1 R4 / ST2 34533 79493 135618 101133
## IL-1 R6 / IL-1 R rp2 0 3699 2799 3131
## IL-1 R9 0 902 1 1065
## IL-1 RI 0 13608 107099 6295
## IL-1 RII 0 16781 11048 11231
## IL-2 0 4645 783 1
## IL-2 R alpha 0 5397 2285 2434
## IL-2 R beta 0 6125 2103 3648
## IL-3 0 5144 3827 2868
## IL-3 R alpha 0 13454 7155 8347
## IL-3 R beta 0 9213 4980 5660
## IL-4 0 6342 2698 6238
## IL-4 R 0 5005 3165 9276
## IL-5 0 10693 7082 7030
## IL-5 R alpha 0 2040 4147 1733
## IL-6 0 1523 1618 972
## IL-6 R 0 2208 938 2279
## IL-7 0 2032 0 310
## IL-7 R alpha 0 3135 1541 1254
## IL-9 306366 54636 17908 15342
## IL-9 R 1591 42286 20079 23909
## IL-10 0 6407 6179 4440
## IL-10 R alpha 0 0 4952 73514
## IL-11 9534 101964 117174 97555
## IL-12 p40/p70 0 5871 5507 3421
## IL-12 p70 0 6343 8220 6033
## IL-12 R beta 1 0 2880 1440 2971
## IL-13 0 6172 4712 12781
## IL-13 R alpha 2 0 7517 3014 6922
## IL-15 0 7492 5190 7753
## IL-15 R alpha 0 15598 29276 15611
## IL-16 27150 15808 95983 84261
## IL-17 0 15046 9482 4228
## IL-17BR 0 16936 4373 12191
## IL-17C 0 0 0 0
## IL-17D 0 4711 2002 3834
## IL-17E 0 10434 3701 5800
## IL-17F 0 4204 0 1543
## IL-17R 0 23546 53604 43032
## IL-17RC 0 5543 2280 4518
## IL-17RD 0 17131 3391 14761
## IL-18 R alpha/IL-1 R5 0 10178 6970 10349
## IL-20 0 13057 2870 9228
## IL-20 R alpha 0 7218 7343 4200
## IL-21 0 2978 1343 1002
## IL-21 R 0 7200 4798 5636
## IL-22 0 8889 4103 5569
## IL-22BP 0 3906 1427 1931
## IL-23 0 894 0 1
## IL-23 R 14211 51735 93838 158739
## IL-24 0 6081 3143 2690
## IL-27 9704 95083 90261 71732
## IL-28 / IFN-lambda 3300 57613 92712 82695
## IL-31 0 10178 34189 20522
## IL-31 RA 0 6490 1146 3404
## Insulin 0 4532 1637 5222
## Integrin beta 2 / CD18 0 7504 6344 6087
## I-TAC 0 2526 370 1082
## KC 0 6006 2713 9143
## Kremen-1 0 4740 2422 4601
## Kremen-2 0 4260 1702 3421
## Lefty-1 0 11950 4264 7538
## Leptin R 0 7455 508 3638
## LEPTIN(OB) 0 631 159 1144
## LIF 0 15430 7636 8134
## LIGHT / TNFSF14 0 3022 1097 2731
## LIX 1 24279 56101 44779
## LRP-6 0 7014 1 6775
## L-Selectin 2088 20228 15675 13970
## Lungkine 0 7473 19839 8131
## Lymphotactin 0 5211 1693 4245
## Lymphotoxin beta R / TNFRSF3 19179 67037 211154 49505
## MAdCAM-1 0 8450 5045 5810
## MCP-1 0 2591 1441 27968
## MCP-5 0 7202 5656 5493
## M-CSF 4904 7252 18483 34165
## MDC 1059 21635 9698 28066
## MFG-E8 0 6608 1795 5260
## MFRP 0 24881 21644 24905
## MIG 0 2713 519 1437
## MIP-1 alpha 0 5049 1467 3657
## MIP-1 gamma 0 11955 5401 6091
## MIP-2 0 8921 16308 8186
## MIP-3 alpha 0 5792 2362 8270
## MIP-3 beta 0 7695 3280 4783
## MMP-2 0 10779 9526 4589
## MMP-3 0 11779 7886 12149
## MMP-9 0 3093 2678 4803
## MMP-12 0 2695 1088 4223
## MMP-14 / LEM-2 0 2021 1351 1
## MMP-24 / MT5-MMP 0 4648 2032 5756
## Neuregulin-3 / NRG3 0 3164 1838 2784
## Neurturin 0 4691 1217 3484
## NGF R / TNFRSF16 0 3190 1890 1200
## NOV / CCN3 0 8047 3963 5870
## Osteoactivin / GPNMB 0 12988 67529 8529
## Osteopontin 3574 16485 14007 18691
## Osteoporotegerin 629 16879 10495 18001
## OX40 Ligand / TNFSF4 0 6839 3528 6815
## PDGF C 0 7591 6512 7549
## PDGF R alpha 0 7025 2499 5813
## PDGF R beta 0 10187 6358 6243
## Pentraxin3 / TSG-14 0 12215 26050 17716
## PF-4 2362 9363 13527 15030
## PlGF-2 0 8893 7331 14666
## Progranulin 13952 26040 23734 23610
## Prolactin 21840 33901 31116 31162
## P-Selectin 0 10435 15913 8800
## RAGE 0 14419 8251 7658
## RANTES 9264 12025 17749 9238
## RELM beta 46197 176992 51095 80738
## Resistin 0 5439 2511 5766
## S100A10 0 5236 1729 3067
## SCF 0 1380 2269 2892
## SCF R / c-kit 0 8447 4850 21082
## SDF-1 0 5343 4299 9185
## Serum Amyloid A1 0 3839 3363 8290
## Shh-N 0 8411 7659 15252
## SIGIRR 0 8508 6205 4920
## SLPI 3127 6122 3557 4016
## Soggy-1 0 17897 19904 25058
## SPARC 5472 27425 53958 49581
## Spinesin Ectodomain 0 3556 497 2267
## TACI / TNFRSF13B 0 8838 3451 4205
## TARC 0 70216 4925 11794
## TCA-3 11477 21245 74408 22755
## TCCR / WSX-1 0 12672 60304 21931
## TECK 0 10014 4309 4868
## TFPI 1 4728 4572 3598
## TGF-beta 1 0 13358 7374 9807
## TGF-beta 2 0 1 0 1241
## TGF-beta 3 17943 1 6879 13903
## TGF-beta RI / ALK-5 0 4437 1642 4415
## TGF-beta RII 4888 80141 108750 112626
## Thrombospondin 8169 1 0 4814
## Thymus Chemokine-1 21533 12934 24427 6242
## Tie-2 0 3373 1336 1952
## TIMP-1Â 0 5095 4720 4620
## TIMP-2 10288 28125 51251 29000
## TIMP-4 0 1432 18197 16523
## TL1A / TNFSF15 0 12265 3960 15560
## TLR1 0 2693 694 2627
## TLR2 28 20823 142649 41435
## TLR3 0 3260 1 2023
## TLR4 0 9699 4389 8340
## TMEFF1 / Tomoregulin-1 0 4423 2013 3986
## TNF RI / TNFRSF1A 0 2085 4456 5923
## TNF RII 0 4316 13847 147054
## TNF-alpha 0 3525 987 45
## TNF-beta / TNFSF1B 1 17006 15669 14725
## TPO 0 10799 2394 3818
## TRAIL / TNFSF10 113205 14383 7120 6334
## TRAIL R2 / TNFRSF10B 0 11622 5130 7748
## TRANCE / TNFSF11 0 9069 3475 8723
## TREM-1 0 4454 1403 3683
## TROY 0 3291 1056 4154
## TSLP 3077 8904 3702 13852
## TSLP R 0 13184 18139 20125
## TWEAK / TNFSF12 0 10314 5285 8078
## TWEAK R / TNFRSF12 0 12684 31578 1
## Ubiqultin 0 2295 1199 1308
## uPAR 0 7360 4180 6889
## Urokinase 0 12938 12639 10468
## VCAM-1 5687 11231 15703 28560
## VE-Cadherin 24608 7030 17207 6080
## VEGF 0 3166 1333 2028
## VEGF R1 0 1264 586 1368
## VEGF R2 0 12941 4388 9039
## VEGF R3 0 6912 3234 5100
## VEGF-B 9435 19673 74977 26327
## VEGFC 3799 48660 80449 39539
## VEGF-D 0 4549 1 3896
## WIF-1 0 1838 1 2739
## WISP-1 / CCN4 0 8544 55965 16806
## Aged+IGF2 Young Young Young Young
## POS-Ave 120414 120414 120414 120414 120414
## Neg-Ave 0 0 0 0 0
## 6Ckine 345 720 0 1 0
## Activin AÂ 1175 4451 1926 4281 1724
## Activin C 0 0 0 0 0
## Activin RIB / ALK-4 0 1666 2871 3258 1791
## Adiponectin / Acrp30 2474 3707 4281 6556 597
## AgRP 2584 2534 1 8324 19460
## ALCAM 0 0 0 0 19
## Angiopoietin-like 2 4631 5332 5154 9326 3659
## Angiopoietin-like 3 6000 6589 8219 8288 540
## AR (Amphiregulin) 1 0 0 525 0
## Artemin 11279 12978 13579 14359 17451
## Axl 10628 9848 4752 8092 4034
## b FGF 6661 27333 11648 41751 18381
## B7-1/CD80 6967 9318 11237 9159 4969
## BAFF R / TNFRSF13C 10683 10702 12904 12297 10063
## BCMA / TNFRSF17 1776 6725 7471 8382 4515
## beta-Catenin 777 359 2972 1726 1550
## BLC 2096 2593 2703 3971 1708
## BTC (Betacellulin) 8832 6899 7912 8785 7809
## Cardiotrophin-1 11257 13677 13397 15842 9470
## IL-1ra 13032 16366 13841 29677 9929
## CCL28 23058 54796 14246 56804 29970
## CCL4 / MIP-1 beta 10905 14603 14151 16568 8251
## CCL7 / MCP-3 / MARC 2839 3352 2727 2689 0
## CCL8 / MCP-2 7366 10818 6680 8258 2274
## CCR10 364 1100 67 761 0
## CCR3 2849 5559 6687 6366 2303
## CCR4 18637 25519 23404 20371 5017
## CCR6 6651 25950 37458 38642 5966
## CCR7 4050 5907 5033 5877 4525
## CCR9 8256 4188 6877 5845 9042
## CD11b 3744 8278 5354 7740 4180
## CD14 2708 3698 4109 5195 2287
## CRP 22939 32955 8887 39110 26873
## CD27 / TNFRSF7 0 0 0 1 0
## CD27 Ligand / TNFSF7 6501 10009 16689 11216 7085
## CD30 9114 4263 6257 6220 2603
## CD30 L 2071 2632 2877 4156 514
## CD40 3663 5793 5123 5636 3000
## CD40 Ligand / TNFSF5 5794 11521 0 9528 5138
## Cerberus 1 0 1 0 0 0
## Chordin-Like 2 993 2036 1 2068 1
## Coagulation Factor III / Tissue Factor 33992 1565 1483 1184 221
## Common gamma Chain / IL-2 R gamma 13378 23570 10520 25922 15793
## CRG-2 6201 11225 9633 11150 5829
## Cripto 3789 4880 6454 7858 3661
## Crossveinless-2 24589 2989 9026 4573 6484
## Cryptic 3015 4039 5674 5884 3057
## Csk 8861 7223 25830 13920 11428
## CTACKÂ 1 38488 19875 37323 28362
## CTLA-4 / CD152 5670 11886 7423 10614 8851
## CXCL14 / BRAK 6825 9672 8163 10960 7296
## CXCL16 8475 13951 10713 11080 7137
## CXCR2 / IL-8 RB 11253 6885 8531 8822 4006
## CXCR3 4006 6939 7944 8177 3774
## CXCR4 1203 2151 0 5 1584
## CXCR6 9288 11931 11386 17766 6504
## EGF 6432 7107 11144 6514 4851
## Decorin 6597 11768 8603 9720 6307
## DKK-1 4948 5483 4326 6508 3201
## Dkk-3 11531 7863 7321 12482 5637
## Dkk-4 2831 1365 2534 2992 0
## DPPIV / CD26 15509 12758 15545 13455 10880
## DR3 / TNFRSF25 4433 0 364 739 0
## Dtk 9362 35151 9286 11004 34611
## EDAR 6666 8489 11940 9910 4133
## EGF R 5019 9548 8182 9499 5548
## EG-VEGF / PK1 5473 22427 11106 24237 7545
## Endocan 4132 13099 7593 27901 5627
## Endoglin / CD105 6990 9460 10547 10222 4423
## Endostatin 11159 18123 17417 30798 10362
## Eotaxin 2408 1430 0 1610 1193
## Eotaxin-2 8513 13451 9344 14642 8812
## Epigen 4086 4765 5007 6097 2909
## Epiregulin 16430 9168 11581 13281 8204
## Erythropoietin (EPO) 7218 5903 7693 8641 3773
## E-Selectin 11169 14591 15396 15914 9541
## FADD 7303 13555 11139 13208 13857
## FAM3B 5899 6706 8698 8261 4083
## Fas / TNFRSF6 1307272 955426 1168815 951465 1305024
## Fas Ligand 4660 4963 2393 3774 2878
## FCrRIIB / CD32b 4974 7181 6717 7139 3104
## FGF R3 2458 5486 3876 4677 1744
## FGF R4 1414 2206 449 2686 575
## FGF R5 beta 4472 7425 10940 9575 2968
## FGF-21 3269 4096 4168 4348 2884
## Fit-3 Ligand 2243 906 1 1243 1
## FLRG (Follistatin) 3727 5272 3070 5305 3465
## Follistatin-like 1 8625 11370 9344 12741 8794
## Fractalkine 6307 4437 5275 11885 3043
## Frizzled-1 6278 8296 10179 8019 2520
## Frizzled-6 12388 22670 11985 32094 15952
## Frizzled-7 6313 9208 5908 10590 4536
## Galectin-3 7390 9913 12508 12471 4725
## G-CSF 6406 8938 9267 8534 5254
## GDF-1 11625 9492 11217 10609 9648
## GDF-3 5869 9203 10568 10131 4261
## GDF-5 13020 15794 13182 28350 10123
## GDF-8 14200 24413 14467 34380 10470
## GDF-9 2154 660 1 1313 0
## GFR alpha-2 / GDNF R alpha-2 3894 4559 6236 6113 2409
## GFR alpha-3 / GDNF R alpha-3 3133 3564 3850 4850 1804
## GFR alpha-4 / GDNF R alpha-4 9134 16127 7760 10886 5937
## GITR 5057 7780 9121 7279 4047
## GITR Ligand / TNFSF18 12003 3233 4340 4360 1730
## Glut2 14140 38595 8216 35496 16583
## GM-CSF 6287 9003 8611 9781 3603
## Granzyme B 4459 8196 8487 9975 3792
## Granzyme D 1511 6493 7895 8157 4241
## Granzyme G 2303 3054 4497 4223 1
## Gremlin 1108 171 407 687 0
## Growth Hormone R 2063 2122 1692 2851 1
## HGF R 5078 5957 8840 8084 1630
## HGFÂ 2202 1854 2224 2607 1
## HVEM / TNFRSF14 13256 10292 12064 11609 9542
## ICAM-1 28711 24221 11903 69383 22664
## ICAM-2 / CD102 2791 3044 3927 5400 1420
## ICAM-5 3648 5258 3880 8420 3208
## ICK 10239 25761 21498 16148 18266
## IFN-alpha / beta R1 2268 3032 4559 4807 1298
## IFN-alpha / beta R2 7622 7031 2424 9326 3668
## IFN-beta 2223 3536 3522 3565 1878
## IFN-gamma 3362 7673 5067 7479 4764
## IFN-gamma R1 14409 61346 10277 33039 9501
## IGFBP-1 7551 19450 9750 29632 7761
## IGFBP-2 6975 13411 11108 22805 5904
## IGFBP-3 11161 27410 13902 34676 13083
## IGFBP-5 7035 14505 18344 16340 7598
## IGFBP-6 978 23 1 1 0
## IGFBP-L1 1731 1189 164 2064 0
## IGF-I 14442 23134 22950 19544 14360
## IGF-II 11243 11586 13971 14718 6710
## IL-1 alpha 18867 54087 12859 42915 10001
## IL-1 beta 3626 3941 2424 3610 2911
## IL-1 R4 / ST2 80356 103297 123695 90845 68289
## IL-1 R6 / IL-1 R rp2 2916 4895 5943 5638 2181
## IL-1 R9 1241 875 502 1224 0
## IL-1 RI 5176 25658 0 26676 5603
## IL-1 RII 12205 12254 20262 14430 8205
## IL-2 2754 2385 2829 3175 1
## IL-2 R alpha 37259 3575 5796 5323 8972
## IL-2 R beta 3497 5278 5826 5715 1204
## IL-3 2834 4754 4041 4814 3432
## IL-3 R alpha 6111 6523 10641 11435 6714
## IL-3 R beta 6306 7126 9131 10826 5255
## IL-4 3343 9348 2739 6333 8194
## IL-4 R 5142 7984 7055 8785 4439
## IL-5 5483 10588 7089 8921 6349
## IL-5 R alpha 2549 3570 0 4112 3829
## IL-6 1559 2938 3127 2646 2385
## IL-6 R 2749 2884 1761 2668 154
## IL-7 2347 2078 2739 2527 0
## IL-7 R alpha 3595 4760 6820 5469 1106
## IL-9 30514 1 8599 9020 74926
## IL-9 R 19839 19450 29433 21523 18263
## IL-10 4322 8134 5573 7635 0
## IL-10 R alpha 2024 1 2197 7148 1
## IL-11 11587 148318 19032 77878 23833
## IL-12 p40/p70 3556 5525 4010 4776 1
## IL-12 p70 4143 14104 7560 9800 6376
## IL-12 R beta 1 2271 2916 4557 3938 155
## IL-13 5232 4498 4157 4099 3067
## IL-13 R alpha 2 4450 6673 11678 10612 2747
## IL-15 5689 5037 4908 6680 2018
## IL-15 R alpha 6912 13665 9356 17223 3338
## IL-16 14426 23663 12202 48925 11076
## IL-17 5163 13530 5414 9234 6268
## IL-17BR 5819 1 9343 9710 3640
## IL-17C 204 0 1 118 0
## IL-17D 2514 3730 3853 4843 2287
## IL-17E 3957 9526 8592 9586 4764
## IL-17F 1807 995 1272 1904 764
## IL-17R 5125 36580 15041 24821 7499
## IL-17RC 5048 5851 8718 6225 4473
## IL-17RD 3919 12942 7764 7972 2844
## IL-18 R alpha/IL-1 R5 7518 14342 6767 7366 5728
## IL-20 7199 14413 10848 10688 7594
## IL-20 R alpha 6850 13138 6913 11911 7496
## IL-21 3094 3313 3469 4358 1
## IL-21 R 4013 9960 6277 8806 4290
## IL-22 5204 10511 8521 8850 2575
## IL-22BP 2219 3992 4726 5157 1
## IL-23 1291 2310 464 2002 1
## IL-23 R 9263 66748 9650 52743 15196
## IL-24 2598 6431 4459 5875 4768
## IL-27 10733 104232 17465 43739 13211
## IL-28 / IFN-lambda 10892 66038 23021 33529 11672
## IL-31 5608 13679 4960 11041 5217
## IL-31 RA 2958 3486 4689 3094 1200
## Insulin 3128 4866 5566 5348 1313
## Integrin beta 2 / CD18 9493 5217 5640 5436 2887
## I-TAC 2297 1659 2649 2048 1
## KC 5130 6828 5470 7607 3504
## Kremen-1 3578 7007 7219 9188 2109
## Kremen-2 3331 4739 5805 6193 2020
## Lefty-1 6494 8024 10001 9816 4243
## Leptin R 3341 4622 4254 4689 2496
## LEPTIN(OB) 1612 1767 2044 2299 1
## LIF 4313 21951 12091 1 6939
## LIGHT / TNFSF14 1744 2610 1790 2871 1322
## LIX 5351 42592 4085 29458 8510
## LRP-6 5938 10267 5028 9699 4259
## L-Selectin 14928 20443 23370 15757 12219
## Lungkine 2694 7506 5154 7963 3179
## Lymphotactin 2759 5591 14690 5404 2406
## Lymphotoxin beta R / TNFRSF3 10298 31592 18328 47366 20024
## MAdCAM-1 4854 11951 7751 10695 4164
## MCP-1 2577 3233 3546 4339 1311
## MCP-5 6470 11296 17192 15256 4766
## M-CSF 4299 31041 5817 41406 8724
## MDC 13081 16726 21356 18741 14435
## MFG-E8 2735 4877 3789 4592 2931
## MFRP 35439 6911 8531 7045 3097
## MIG 1547 2628 1914 2485 612
## MIP-1 alpha 1513 3642 1795 3154 1691
## MIP-1 gamma 3708 7041 1740 4608 4293
## MIP-2 4091 13538 7045 10914 3839
## MIP-3 alpha 2520 5385 3809 4279 3654
## MIP-3 beta 3207 3731 4981 4149 2912
## MMP-2 8281 12851 19109 10591 9950
## MMP-3 7552 9387 19059 10330 4334
## MMP-9 3309 3583 3789 3947 3489
## MMP-12 1723 2584 2918 2793 2410
## MMP-14 / LEM-2 2094 2506 3218 3255 0
## MMP-24 / MT5-MMP 3209 3578 5622 5531 2559
## Neuregulin-3 / NRG3 2922 3698 3922 3852 1231
## Neurturin 2816 4998 4891 4471 1623
## NGF R / TNFRSF16 2943 5357 4786 4065 2053
## NOV / CCN3 4713 7780 7468 7481 4069
## Osteoactivin / GPNMB 4095 22090 8772 11992 5924
## Osteopontin 14988 15341 27538 17433 10426
## Osteoporotegerin 8603 13722 11862 13114 6436
## OX40 Ligand / TNFSF4 3314 8420 8396 9151 2641
## PDGF C 4574 14816 8570 10166 6498
## PDGF R alpha 2934 7124 6283 7098 1379
## PDGF R beta 5412 12910 15272 11516 5198
## Pentraxin3 / TSG-14 4278 21116 9887 24617 4963
## PF-4 3403 26969 23820 43940 6429
## PlGF-2 7673 8660 7711 8457 3393
## Progranulin 18128 28661 35221 23559 19314
## Prolactin 10514 33334 26813 25133 14016
## P-Selectin 3173 8842 3564 10000 4757
## RAGE 9128 13140 8792 10010 5454
## RANTES 7803 17797 7548 13263 7794
## RELM beta 34766 30028 36141 13374 9999
## Resistin 3587 6871 7638 6679 3880
## S100A10 2570 4234 5070 4768 1369
## SCF 2522 2588 4293 3681 582
## SCF R / c-kit 5914 11108 11167 10957 3113
## SDF-1 1723 5432 3630 4909 872
## Serum Amyloid A1 3553 5743 8977 6770 5051
## Shh-N 9232 13421 12274 13265 5259
## SIGIRR 4950 12832 8757 10342 5282
## SLPI 3391 15977 28740 34797 1
## Soggy-1 5630 15561 6572 10701 5964
## SPARC 11357 30355 13289 19443 13900
## Spinesin Ectodomain 2413 4399 4454 4233 656
## TACI / TNFRSF13B 8529 8147 9451 8525 3749
## TARC 6795 12827 17705 12552 4770
## TCA-3 5706 14885 11583 18625 9228
## TCCR / WSX-1 4564 10484 7069 15648 5294
## TECK 4836 8635 10184 8908 16896
## TFPI 5131 4421 5300 1995 2668
## TGF-beta 1 4993 9359 7473 8821 3445
## TGF-beta 2 609 0 3823 1 0
## TGF-beta 3 305 6434 10223 1833 0
## TGF-beta RI / ALK-5 2248 3065 2701 2718 289
## TGF-beta RII 11418 82000 22645 30584 12190
## Thrombospondin 1958 570 2341 931 0
## Thymus Chemokine-1 4358 14824 32440 23514 4339
## Tie-2 2648 4134 4764 5590 1592
## TIMP-1Â 5512 3342 5949 3953 3906
## TIMP-2 11342 41575 15138 19122 12264
## TIMP-4 1673 5996 4258 6479 1
## TL1A / TNFSF15 4314 6678 7943 7072 2633
## TLR1 1640 2876 2258 2248 237
## TLR2 7694 86148 14153 49942 11204
## TLR3 1998 3246 4517 3288 930
## TLR4 4255 9550 8531 9410 4046
## TMEFF1 / Tomoregulin-1 3727 5045 6733 6667 1241
## TNF RI / TNFRSF1A 3221 7189 3277 6135 2142
## TNF RII 2994 8815 6003 4725 3766
## TNF-alpha 2228 3510 2749 3452 704
## TNF-beta / TNFSF1B 4868 17760 8651 16182 7720
## TPO 4115 7416 9200 8394 3229
## TRAIL / TNFSF10 8888 29810 13035 9500 20018
## TRAIL R2 / TNFRSF10B 5211 7091 8478 7477 3143
## TRANCE / TNFSF11 5907 8382 8082 8994 3218
## TREM-1 2218 4334 4815 4741 1312
## TROY 3039 3672 4513 3994 1
## TSLP 4813 7615 8740 7735 2862
## TSLP R 5742 16019 8451 12450 3518
## TWEAK / TNFSF12 6116 11482 11327 11733 4757
## TWEAK R / TNFRSF12 4266 14579 6854 9137 5483
## Ubiqultin 3946 1717 6790 2850 1880
## uPAR 4470 6932 8341 7690 2558
## Urokinase 3589 12878 2230 9990 11297
## VCAM-1 15361 17481 22692 13899 11473
## VE-Cadherin 2852 17554 2117 6365 7388
## VEGF 2351 1963 3045 2943 857
## VEGF R1 1169 1942 1562 2471 1
## VEGF R2 5967 9273 8982 8006 1
## VEGF R3 3075 5347 6367 6508 1830
## VEGF-B 8111 25688 10036 30727 6438
## VEGFC 11231 66436 12079 67241 17209
## VEGF-D 3127 5169 3588 3801 1834
## WIF-1 1291 2254 1505 1609 1
## WISP-1 / CCN4 4717 18663 4697 9919 5176
## Young
## POS-Ave 120414
## Neg-Ave 0
## 6Ckine 0
## Activin AÂ 2312
## Activin C 0
## Activin RIB / ALK-4 0
## Adiponectin / Acrp30 3108
## AgRP 3035
## ALCAM 461
## Angiopoietin-like 2 7909
## Angiopoietin-like 3 9984
## AR (Amphiregulin) 0
## Artemin 12192
## Axl 6341
## b FGF 18548
## B7-1/CD80 8288
## BAFF R / TNFRSF13C 10641
## BCMA / TNFRSF17 5606
## beta-Catenin 607
## BLC 1488
## BTC (Betacellulin) 5471
## Cardiotrophin-1 12456
## IL-1ra 13309
## CCL28 20276
## CCL4 / MIP-1 beta 10952
## CCL7 / MCP-3 / MARC 1
## CCL8 / MCP-2 6047
## CCR10 191
## CCR3 4253
## CCR4 17238
## CCR6 18422
## CCR7 5133
## CCR9 7021
## CD11b 5820
## CD14 2807
## CRP 31673
## CD27 / TNFRSF7 0
## CD27 Ligand / TNFSF7 10030
## CD30 3715
## CD30 L 2353
## CD40 5039
## CD40 Ligand / TNFSF5 5832
## Cerberus 1 0
## Chordin-Like 2 707
## Coagulation Factor III / Tissue Factor 126
## Common gamma Chain / IL-2 R gamma 24608
## CRG-2 9219
## Cripto 3673
## Crossveinless-2 2378
## Cryptic 2529
## Csk 11592
## CTACKÂ 40334
## CTLA-4 / CD152 9463
## CXCL14 / BRAK 10865
## CXCL16 11698
## CXCR2 / IL-8 RB 6010
## CXCR3 6144
## CXCR4 0
## CXCR6 17434
## EGF 7352
## Decorin 24910
## DKK-1 4790
## Dkk-3 5852
## Dkk-4 1200
## DPPIV / CD26 9377
## DR3 / TNFRSF25 1
## Dtk 284212
## EDAR 8675
## EGF R 8061
## EG-VEGF / PK1 18301
## Endocan 16483
## Endoglin / CD105 8513
## Endostatin 27360
## Eotaxin 1
## Eotaxin-2 16907
## Epigen 3846
## Epiregulin 10025
## Erythropoietin (EPO) 6283
## E-Selectin 12391
## FADD 11100
## FAM3B 6073
## Fas / TNFRSF6 818428
## Fas Ligand 2759
## FCrRIIB / CD32b 6307
## FGF R3 29355
## FGF R4 369
## FGF R5 beta 8584
## FGF-21 3129
## Fit-3 Ligand 0
## FLRG (Follistatin) 6427
## Follistatin-like 1 16131
## Fractalkine 2251
## Frizzled-1 10456
## Frizzled-6 29816
## Frizzled-7 8844
## Galectin-3 8878
## G-CSF 7506
## GDF-1 5606
## GDF-3 8886
## GDF-5 18523
## GDF-8 27056
## GDF-9 1
## GFR alpha-2 / GDNF R alpha-2 3872
## GFR alpha-3 / GDNF R alpha-3 3211
## GFR alpha-4 / GDNF R alpha-4 18641
## GITR 6287
## GITR Ligand / TNFSF18 2774
## Glut2 47181
## GM-CSF 6342
## Granzyme B 6111
## Granzyme D 4227
## Granzyme G 2185
## Gremlin 0
## Growth Hormone R 1
## HGF R 5467
## HGFÂ 1080
## HVEM / TNFRSF14 9164
## ICAM-1 71381
## ICAM-2 / CD102 1072
## ICAM-5 4559
## ICK 10461
## IFN-alpha / beta R1 2277
## IFN-alpha / beta R2 6651
## IFN-beta 4368
## IFN-gamma 5776
## IFN-gamma R1 22641
## IGFBP-1 20979
## IGFBP-2 20928
## IGFBP-3 32911
## IGFBP-5 14459
## IGFBP-6 0
## IGFBP-L1 1
## IGF-I 21559
## IGF-II 16017
## IL-1 alpha 34454
## IL-1 beta 590
## IL-1 R4 / ST2 134457
## IL-1 R6 / IL-1 R rp2 3239
## IL-1 R9 1
## IL-1 RI 16615
## IL-1 RII 12675
## IL-2 1442
## IL-2 R alpha 3046
## IL-2 R beta 5121
## IL-3 4829
## IL-3 R alpha 11668
## IL-3 R beta 13324
## IL-4 12851
## IL-4 R 5621
## IL-5 6508
## IL-5 R alpha 3278
## IL-6 1863
## IL-6 R 0
## IL-7 0
## IL-7 R alpha 4294
## IL-9 133977
## IL-9 R 54541
## IL-10 7481
## IL-10 R alpha 1
## IL-11 58958
## IL-12 p40/p70 3850
## IL-12 p70 7270
## IL-12 R beta 1 2162
## IL-13 2737
## IL-13 R alpha 2 5263
## IL-15 2022
## IL-15 R alpha 12596
## IL-16 27590
## IL-17 9681
## IL-17BR 10365
## IL-17C 1
## IL-17D 3557
## IL-17E 5660
## IL-17F 1
## IL-17R 34061
## IL-17RC 4046
## IL-17RD 6717
## IL-18 R alpha/IL-1 R5 7922
## IL-20 11437
## IL-20 R alpha 7776
## IL-21 1289
## IL-21 R 6896
## IL-22 14357
## IL-22BP 3678
## IL-23 259
## IL-23 R 63035
## IL-24 4341
## IL-27 46786
## IL-28 / IFN-lambda 46705
## IL-31 14429
## IL-31 RA 408
## Insulin 1
## Integrin beta 2 / CD18 2825
## I-TAC 1
## KC 1858
## Kremen-1 1954
## Kremen-2 3287
## Lefty-1 7897
## Leptin R 4939
## LEPTIN(OB) 1
## LIF 20616
## LIGHT / TNFSF14 1
## LIX 38544
## LRP-6 12648
## L-Selectin 32993
## Lungkine 10647
## Lymphotactin 3057
## Lymphotoxin beta R / TNFRSF3 24965
## MAdCAM-1 5560
## MCP-1 1829
## MCP-5 8256
## M-CSF 23969
## MDC 17324
## MFG-E8 5451
## MFRP 4597
## MIG 0
## MIP-1 alpha 1291
## MIP-1 gamma 4644
## MIP-2 14151
## MIP-3 alpha 4049
## MIP-3 beta 3291
## MMP-2 10990
## MMP-3 3118
## MMP-9 0
## MMP-12 1085
## MMP-14 / LEM-2 175
## MMP-24 / MT5-MMP 2955
## Neuregulin-3 / NRG3 4163
## Neurturin 4197
## NGF R / TNFRSF16 3157
## NOV / CCN3 6352
## Osteoactivin / GPNMB 20342
## Osteopontin 13143
## Osteoporotegerin 10879
## OX40 Ligand / TNFSF4 5669
## PDGF C 8265
## PDGF R alpha 3331
## PDGF R beta 7407
## Pentraxin3 / TSG-14 16320
## PF-4 20251
## PlGF-2 3221
## Progranulin 22335
## Prolactin 53175
## P-Selectin 12818
## RAGE 9954
## RANTES 15119
## RELM beta 19703
## Resistin 5996
## S100A10 1454
## SCF 1
## SCF R / c-kit 5244
## SDF-1 1250
## Serum Amyloid A1 4211
## Shh-N 5972
## SIGIRR 6299
## SLPI 8579
## Soggy-1 17406
## SPARC 43802
## Spinesin Ectodomain 2705
## TACI / TNFRSF13B 7700
## TARC 11215
## TCA-3 33622
## TCCR / WSX-1 20082
## TECK 6743
## TFPI 2467
## TGF-beta 1 7620
## TGF-beta 2 0
## TGF-beta 3 1
## TGF-beta RI / ALK-5 663
## TGF-beta RII 46315
## Thrombospondin 245
## Thymus Chemokine-1 20482
## Tie-2 2586
## TIMP-1Â 2947
## TIMP-2 20467
## TIMP-4 4058
## TL1A / TNFSF15 4825
## TLR1 970
## TLR2 32826
## TLR3 259
## TLR4 5758
## TMEFF1 / Tomoregulin-1 2102
## TNF RI / TNFRSF1A 678
## TNF RII 3247
## TNF-alpha 1274
## TNF-beta / TNFSF1B 25370
## TPO 6134
## TRAIL / TNFSF10 57040
## TRAIL R2 / TNFRSF10B 5614
## TRANCE / TNFSF11 4552
## TREM-1 3532
## TROY 2223
## TSLP 3780
## TSLP R 12601
## TWEAK / TNFSF12 7992
## TWEAK R / TNFRSF12 17089
## Ubiqultin 2083
## uPAR 4615
## Urokinase 20279
## VCAM-1 7907
## VE-Cadherin 20748
## VEGF 1099
## VEGF R1 475
## VEGF R2 9829
## VEGF R3 4262
## VEGF-B 40952
## VEGFC 42711
## VEGF-D 1121
## WIF-1 1
## WISP-1 / CCN4 30919for (i in unique(colnames(temp_df))) {
temp_df[paste0(i, ' ')] <- temp_df[colnames(temp_df)==i]
}## Warning in `[<-.data.frame`(`*tmp*`, paste0(i, " "), value = structure(list(:
## provided 5 variables to replace 1 variablestemp_df_mean <- temp_df[c(26:30)]
temp_df_mean## Aged Aged+NaB Aged+Combo Aged+IGF2
## POS-Ave 120414 120414 120414 120414
## Neg-Ave 0 0 0 0
## 6Ckine 0 0 2003 0
## Activin AÂ 517 93426 4679 0
## Activin C 0 0 0 0
## Activin RIB / ALK-4 0 0 0 7093
## Adiponectin / Acrp30 634 0 5124 0
## AgRP 1006 26962 21584 0
## ALCAM 0 0 0 0
## Angiopoietin-like 2 3132 18451 6618 0
## Angiopoietin-like 3 1 5821 8733 0
## AR (Amphiregulin) 198 0 0 0
## Artemin 3574 145448 22388 0
## Axl 3939 290974 23418 0
## b FGF 11451 82655 44419 0
## B7-1/CD80 6287 69235 7551 0
## BAFF R / TNFRSF13C 5335 6744 9565 0
## BCMA / TNFRSF17 82 1 2727 0
## beta-Catenin 1 0 246 0
## BLC 1656 5356 25143 0
## BTC (Betacellulin) 4912 36699 8360 66559
## Cardiotrophin-1 8647 161044 49578 1
## IL-1ra 9836 122602 66872 1
## CCL28 14780 145389 90782 3641
## CCL4 / MIP-1 beta 5564 60356 26781 81
## CCL7 / MCP-3 / MARC 0 0 1 1
## CCL8 / MCP-2 6707 133539 11730 0
## CCR10 0 0 244 0
## CCR3 1 7821 3462 0
## CCR4 7209 1 16532 18706
## CCR6 64787 20246 40270 0
## CCR7 694 1 4079 0
## CCR9 6102 24045 5220 0
## CD11b 1 3595 4758 0
## CD14 1 0 4107 0
## CRP 22904 162787 25992 1
## CD27 / TNFRSF7 0 0 277 5252
## CD27 Ligand / TNFSF7 1227 53864 12564 102
## CD30 0 0 38176 0
## CD30 L 0 1 208 0
## CD40 1 50482 3552 0
## CD40 Ligand / TNFSF5 9235 16603 4840 6256
## Cerberus 1 0 0 0 0
## Chordin-Like 2 0 0 973 0
## Coagulation Factor III / Tissue Factor 8146 3008 3781 0
## Common gamma Chain / IL-2 R gamma 8788 96471 54215 0
## CRG-2 2189 7345 6476 0
## Cripto 1 1 20962 0
## Crossveinless-2 7463 6191 7167 17574
## Cryptic 0 8871 3106 0
## Csk 2015 31530 5585 16947
## CTACKÂ 89851 359993 68917 11557
## CTLA-4 / CD152 2423 14665 6051 874
## CXCL14 / BRAK 4327 102131 9751 1
## CXCL16 34475 43743 33761 0
## CXCR2 / IL-8 RB 3704 12666 4958 0
## CXCR3 1 10973 5294 0
## CXCR4 0 734 1022 0
## CXCR6 258 112866 9889 0
## EGF 1548 4341 5481 0
## Decorin 253433 123194 156466 1
## DKK-1 0 6678 2996 0
## Dkk-3 3712 54937 6524 0
## Dkk-4 457 0 1431 1
## DPPIV / CD26 12211 28524 56586 1930
## DR3 / TNFRSF25 122 0 1241 237
## Dtk 414233 243736 319097 246372
## EDAR 2909 30689 7523 1
## EGF R 1713 119166 5448 0
## EG-VEGF / PK1 9017 3082 62119 1079
## Endocan 2637 128329 10097 0
## Endoglin / CD105 4533 24060 6870 0
## Endostatin 15497 156135 34320 7717
## Eotaxin 0 0 769 0
## Eotaxin-2 8115 67060 12905 0
## Epigen 962 3958 4072 0
## Epiregulin 12303 31017 9682 17194
## Erythropoietin (EPO) 2561 40788 4635 0
## E-Selectin 2784 87137 8634 0
## FADD 11294 90645 9027 0
## FAM3B 0 0 4097 0
## Fas / TNFRSF6 838607 520805 521386 718673
## Fas Ligand 1409 196764 3191 0
## FCrRIIB / CD32b 11270 10635 20351 0
## FGF R3 127862 15753 54665 0
## FGF R4 0 0 1001 0
## FGF R5 beta 436 19972 5165 0
## FGF-21 741 55095 1499 0
## Fit-3 Ligand 0 0 280 0
## FLRG (Follistatin) 4555 11363 13610 0
## Follistatin-like 1 34079 156666 146689 1
## Fractalkine 465 11378 3409 0
## Frizzled-1 1 75124 3787 0
## Frizzled-6 14221 63047 23874 2498
## Frizzled-7 5573 255946 7018 0
## Galectin-3 3839 12344 9187 1
## G-CSF 1504 119439 5695 0
## GDF-1 6653 4906 7213 0
## GDF-3 3640 24660 5675 0
## GDF-5 14992 103202 13252 0
## GDF-8 13354 152600 23818 1
## GDF-9 0 0 840 0
## GFR alpha-2 / GDNF R alpha-2 0 0 3246 0
## GFR alpha-3 / GDNF R alpha-3 0 0 2726 0
## GFR alpha-4 / GDNF R alpha-4 47937 59782 118069 0
## GITR 1 68217 5147 0
## GITR Ligand / TNFSF18 1 0 3149 0
## Glut2 33102 96126 23361 16996
## GM-CSF 4068 27517 6173 0
## Granzyme B 1767 8379 8148 0
## Granzyme D 0 75778 4489 0
## Granzyme G 235 0 1901 0
## Gremlin 0 0 280 0
## Growth Hormone R 0 0 1088 0
## HGF R 486 7553 8739 0
## HGFÂ 0 0 1250 0
## HVEM / TNFRSF14 2965 5088 8419 0
## ICAM-1 39426 264390 126323 35874
## ICAM-2 / CD102 0 0 2088 0
## ICAM-5 1 0 3776 0
## ICK 3489 0 7707 6749
## IFN-alpha / beta R1 0 1 1863 0
## IFN-alpha / beta R2 1867 9701 11517 0
## IFN-beta 0 2124 849 0
## IFN-gamma 179 12 3770 0
## IFN-gamma R1 5385 117979 23159 0
## IGFBP-1 4669 105222 18366 0
## IGFBP-2 19448 72830 35463 0
## IGFBP-3 7224 92723 29653 1808
## IGFBP-5 4190 0 8260 0
## IGFBP-6 0 0 0 0
## IGFBP-L1 0 0 1127 0
## IGF-I 5371 41889 15609 7256
## IGF-II 3079 0 11511 0
## IL-1 alpha 110978 256470 228360 7493
## IL-1 beta 0 78580 4141 0
## IL-1 R4 / ST2 62036 0 86499 34533
## IL-1 R6 / IL-1 R rp2 0 1371 2706 0
## IL-1 R9 0 0 651 0
## IL-1 RI 5237 70007 21300 0
## IL-1 RII 9392 43182 12514 0
## IL-2 0 0 2055 0
## IL-2 R alpha 4912 3882 3620 0
## IL-2 R beta 1 2030 4958 0
## IL-3 371 1 1730 0
## IL-3 R alpha 511 74055 11871 0
## IL-3 R beta 612 8743 14700 0
## IL-4 0 97045 2875 0
## IL-4 R 0 1561 3765 0
## IL-5 1268 8872 3738 0
## IL-5 R alpha 0 773 2509 0
## IL-6 0 2787 684 0
## IL-6 R 0 0 1413 0
## IL-7 0 0 735 0
## IL-7 R alpha 345 0 2485 0
## IL-9 656694 234179 521284 306366
## IL-9 R 15738 71317 26830 1591
## IL-10 1174 6798 3866 0
## IL-10 R alpha 20248 18745 41903 0
## IL-11 25608 182955 60757 9534
## IL-12 p40/p70 1 3757 2956 0
## IL-12 p70 1750 11764 5264 0
## IL-12 R beta 1 0 0 1804 0
## IL-13 2713 74601 2185 0
## IL-13 R alpha 2 4580 9939 4056 0
## IL-15 4429 19638 3343 0
## IL-15 R alpha 2059 78606 18944 0
## IL-16 6329 369592 63443 27150
## IL-17 2140 35510 7913 0
## IL-17BR 28966 15598 116056 0
## IL-17C 0 0 55 0
## IL-17D 0 0 2670 0
## IL-17E 2065 18219 5131 0
## IL-17F 0 0 965 0
## IL-17R 9862 116015 26070 0
## IL-17RC 1 1686 2479 0
## IL-17RD 40855 9707 136835 0
## IL-18 R alpha/IL-1 R5 6614 209627 5164 0
## IL-20 3310 50525 4333 0
## IL-20 R alpha 1211 189221 4686 0
## IL-21 0 0 1538 0
## IL-21 R 127 124810 6282 0
## IL-22 63867 32467 111206 0
## IL-22BP 0 0 1836 0
## IL-23 0 0 310 0
## IL-23 R 29044 271223 45884 14211
## IL-24 0 0 2243 0
## IL-27 17091 210026 50716 9704
## IL-28 / IFN-lambda 6908 174509 33170 3300
## IL-31 0 59328 9146 0
## IL-31 RA 0 0 1514 0
## Insulin 218 1 2514 0
## Integrin beta 2 / CD18 3230 55165 3536 0
## I-TAC 0 0 619 0
## KC 3785 15215 3674 0
## Kremen-1 0 6840 4356 0
## Kremen-2 0 0 2542 0
## Lefty-1 2035 25950 6235 0
## Leptin R 0 4044 2791 0
## LEPTIN(OB) 0 0 881 0
## LIF 9052 80830 64158 0
## LIGHT / TNFSF14 0 12228 270 0
## LIX 1138 183659 21326 1
## LRP-6 0 75563 6250 0
## L-Selectin 33401 160255 23196 2088
## Lungkine 3452 28401 8244 0
## Lymphotactin 1 1 4216 0
## Lymphotoxin beta R / TNFRSF3 5037 222935 47502 19179
## MAdCAM-1 1228 112585 18507 0
## MCP-1 1 0 1288 0
## MCP-5 1 912 12606 0
## M-CSF 2553 185723 17725 4904
## MDC 19776 53816 10005 1059
## MFG-E8 2674 15969 3488 0
## MFRP 7330 6445 7584 0
## MIG 0 0 952 0
## MIP-1 alpha 0 10533 2660 0
## MIP-1 gamma 4890 217161 4352 0
## MIP-2 191334 126261 7683 0
## MIP-3 alpha 1526 119522 3356 0
## MIP-3 beta 1617 14045 3421 0
## MMP-2 3575 487 6499 0
## MMP-3 2332 24568 6923 0
## MMP-9 812 0 2793 0
## MMP-12 0 0 1979 0
## MMP-14 / LEM-2 0 1443 1318 0
## MMP-24 / MT5-MMP 1 11062 3607 0
## Neuregulin-3 / NRG3 0 0 1890 0
## Neurturin 1 0 2820 0
## NGF R / TNFRSF16 0 0 1908 0
## NOV / CCN3 1862 11754 4106 0
## Osteoactivin / GPNMB 234 52456 24612 0
## Osteopontin 10391 8830 17575 3574
## Osteoporotegerin 13338 72074 7441 629
## OX40 Ligand / TNFSF4 1376 8494 4784 0
## PDGF C 4274 141882 5735 0
## PDGF R alpha 1 10105 3519 0
## PDGF R beta 2073 95676 6623 0
## Pentraxin3 / TSG-14 3890 113361 18930 0
## PF-4 12506 132551 37818 2362
## PlGF-2 3848 33524 5963 0
## Progranulin 18530 19878 21569 13952
## Prolactin 5394 129635 45827 21840
## P-Selectin 1 184174 22181 0
## RAGE 6809 69358 8734 0
## RANTES 4550 252160 10823 9264
## RELM beta 75299 40824 111990 46197
## Resistin 0 22967 3568 0
## S100A10 0 1 2408 0
## SCF 0 0 1293 0
## SCF R / c-kit 35413 14786 41283 0
## SDF-1 1 45641 5620 0
## Serum Amyloid A1 0 30 7651 0
## Shh-N 7222 57824 9914 0
## SIGIRR 1647 95043 8367 0
## SLPI 4796 1 8274 3127
## Soggy-1 4203 145522 33145 0
## SPARC 7021 128464 47787 5472
## Spinesin Ectodomain 0 4956 2745 0
## TACI / TNFRSF13B 397 13249 4949 0
## TARC 8604 60148 7060 0
## TCA-3 6795 221575 34613 11477
## TCCR / WSX-1 2600 124203 18937 0
## TECK 1070 4420 4860 0
## TFPI 453 0 2377 1
## TGF-beta 1 392 1 4641 0
## TGF-beta 2 0 0 0 0
## TGF-beta 3 0 1 7759 17943
## TGF-beta RI / ALK-5 0 7170 1692 0
## TGF-beta RII 13998 146665 62272 4888
## Thrombospondin 2665 0 2460 8169
## Thymus Chemokine-1 87690 69338 330492 21533
## Tie-2 0 1 2045 0
## TIMP-1Â 1 12467 3641 0
## TIMP-2 6862 217751 1 10288
## TIMP-4 136 0 23 0
## TL1A / TNFSF15 104 50174 14130 0
## TLR1 0 0 1188 0
## TLR2 4355 158457 34116 28
## TLR3 0 1 2020 0
## TLR4 1472 12712 4574 0
## TMEFF1 / Tomoregulin-1 0 0 2988 0
## TNF RI / TNFRSF1A 805 92250 4268 0
## TNF RII 0 59440 5719 0
## TNF-alpha 0 9527 1694 0
## TNF-beta / TNFSF1B 762 79104 20595 1
## TPO 290 12234 4532 0
## TRAIL / TNFSF10 259819 101752 278978 113205
## TRAIL R2 / TNFRSF10B 4544 26771 4834 0
## TRANCE / TNFSF11 7019 9780 8658 0
## TREM-1 0 24091 2255 0
## TROY 0 0 1771 0
## TSLP 3524 17663 3256 3077
## TSLP R 2211 54459 12858 0
## TWEAK / TNFSF12 2462 21035 8173 0
## TWEAK R / TNFRSF12 1 83793 13489 0
## Ubiqultin 0 13681 2175 0
## uPAR 1052 9129 12974 0
## Urokinase 0 16077 25869 0
## VCAM-1 9180 16911 24558 5687
## VE-Cadherin 202306 145665 248050 24608
## VEGF 0 863 1447 0
## VEGF R1 0 0 650 0
## VEGF R2 5786 46430 4674 0
## VEGF R3 1 6744 2933 0
## VEGF-B 4029 88712 28568 9435
## VEGFC 5852 29124 46527 3799
## VEGF-D 6796 139 13239 0
## WIF-1 0 1 5985 0
## WISP-1 / CCN4 14118 115138 70449 0
## Young
## POS-Ave 120414
## Neg-Ave 0
## 6Ckine 720
## Activin AÂ 4451
## Activin C 0
## Activin RIB / ALK-4 1666
## Adiponectin / Acrp30 3707
## AgRP 2534
## ALCAM 0
## Angiopoietin-like 2 5332
## Angiopoietin-like 3 6589
## AR (Amphiregulin) 0
## Artemin 12978
## Axl 9848
## b FGF 27333
## B7-1/CD80 9318
## BAFF R / TNFRSF13C 10702
## BCMA / TNFRSF17 6725
## beta-Catenin 359
## BLC 2593
## BTC (Betacellulin) 6899
## Cardiotrophin-1 13677
## IL-1ra 16366
## CCL28 54796
## CCL4 / MIP-1 beta 14603
## CCL7 / MCP-3 / MARC 3352
## CCL8 / MCP-2 10818
## CCR10 1100
## CCR3 5559
## CCR4 25519
## CCR6 25950
## CCR7 5907
## CCR9 4188
## CD11b 8278
## CD14 3698
## CRP 32955
## CD27 / TNFRSF7 0
## CD27 Ligand / TNFSF7 10009
## CD30 4263
## CD30 L 2632
## CD40 5793
## CD40 Ligand / TNFSF5 11521
## Cerberus 1 1
## Chordin-Like 2 2036
## Coagulation Factor III / Tissue Factor 1565
## Common gamma Chain / IL-2 R gamma 23570
## CRG-2 11225
## Cripto 4880
## Crossveinless-2 2989
## Cryptic 4039
## Csk 7223
## CTACKÂ 38488
## CTLA-4 / CD152 11886
## CXCL14 / BRAK 9672
## CXCL16 13951
## CXCR2 / IL-8 RB 6885
## CXCR3 6939
## CXCR4 2151
## CXCR6 11931
## EGF 7107
## Decorin 11768
## DKK-1 5483
## Dkk-3 7863
## Dkk-4 1365
## DPPIV / CD26 12758
## DR3 / TNFRSF25 0
## Dtk 35151
## EDAR 8489
## EGF R 9548
## EG-VEGF / PK1 22427
## Endocan 13099
## Endoglin / CD105 9460
## Endostatin 18123
## Eotaxin 1430
## Eotaxin-2 13451
## Epigen 4765
## Epiregulin 9168
## Erythropoietin (EPO) 5903
## E-Selectin 14591
## FADD 13555
## FAM3B 6706
## Fas / TNFRSF6 955426
## Fas Ligand 4963
## FCrRIIB / CD32b 7181
## FGF R3 5486
## FGF R4 2206
## FGF R5 beta 7425
## FGF-21 4096
## Fit-3 Ligand 906
## FLRG (Follistatin) 5272
## Follistatin-like 1 11370
## Fractalkine 4437
## Frizzled-1 8296
## Frizzled-6 22670
## Frizzled-7 9208
## Galectin-3 9913
## G-CSF 8938
## GDF-1 9492
## GDF-3 9203
## GDF-5 15794
## GDF-8 24413
## GDF-9 660
## GFR alpha-2 / GDNF R alpha-2 4559
## GFR alpha-3 / GDNF R alpha-3 3564
## GFR alpha-4 / GDNF R alpha-4 16127
## GITR 7780
## GITR Ligand / TNFSF18 3233
## Glut2 38595
## GM-CSF 9003
## Granzyme B 8196
## Granzyme D 6493
## Granzyme G 3054
## Gremlin 171
## Growth Hormone R 2122
## HGF R 5957
## HGFÂ 1854
## HVEM / TNFRSF14 10292
## ICAM-1 24221
## ICAM-2 / CD102 3044
## ICAM-5 5258
## ICK 25761
## IFN-alpha / beta R1 3032
## IFN-alpha / beta R2 7031
## IFN-beta 3536
## IFN-gamma 7673
## IFN-gamma R1 61346
## IGFBP-1 19450
## IGFBP-2 13411
## IGFBP-3 27410
## IGFBP-5 14505
## IGFBP-6 23
## IGFBP-L1 1189
## IGF-I 23134
## IGF-II 11586
## IL-1 alpha 54087
## IL-1 beta 3941
## IL-1 R4 / ST2 103297
## IL-1 R6 / IL-1 R rp2 4895
## IL-1 R9 875
## IL-1 RI 25658
## IL-1 RII 12254
## IL-2 2385
## IL-2 R alpha 3575
## IL-2 R beta 5278
## IL-3 4754
## IL-3 R alpha 6523
## IL-3 R beta 7126
## IL-4 9348
## IL-4 R 7984
## IL-5 10588
## IL-5 R alpha 3570
## IL-6 2938
## IL-6 R 2884
## IL-7 2078
## IL-7 R alpha 4760
## IL-9 1
## IL-9 R 19450
## IL-10 8134
## IL-10 R alpha 1
## IL-11 148318
## IL-12 p40/p70 5525
## IL-12 p70 14104
## IL-12 R beta 1 2916
## IL-13 4498
## IL-13 R alpha 2 6673
## IL-15 5037
## IL-15 R alpha 13665
## IL-16 23663
## IL-17 13530
## IL-17BR 1
## IL-17C 0
## IL-17D 3730
## IL-17E 9526
## IL-17F 995
## IL-17R 36580
## IL-17RC 5851
## IL-17RD 12942
## IL-18 R alpha/IL-1 R5 14342
## IL-20 14413
## IL-20 R alpha 13138
## IL-21 3313
## IL-21 R 9960
## IL-22 10511
## IL-22BP 3992
## IL-23 2310
## IL-23 R 66748
## IL-24 6431
## IL-27 104232
## IL-28 / IFN-lambda 66038
## IL-31 13679
## IL-31 RA 3486
## Insulin 4866
## Integrin beta 2 / CD18 5217
## I-TAC 1659
## KC 6828
## Kremen-1 7007
## Kremen-2 4739
## Lefty-1 8024
## Leptin R 4622
## LEPTIN(OB) 1767
## LIF 21951
## LIGHT / TNFSF14 2610
## LIX 42592
## LRP-6 10267
## L-Selectin 20443
## Lungkine 7506
## Lymphotactin 5591
## Lymphotoxin beta R / TNFRSF3 31592
## MAdCAM-1 11951
## MCP-1 3233
## MCP-5 11296
## M-CSF 31041
## MDC 16726
## MFG-E8 4877
## MFRP 6911
## MIG 2628
## MIP-1 alpha 3642
## MIP-1 gamma 7041
## MIP-2 13538
## MIP-3 alpha 5385
## MIP-3 beta 3731
## MMP-2 12851
## MMP-3 9387
## MMP-9 3583
## MMP-12 2584
## MMP-14 / LEM-2 2506
## MMP-24 / MT5-MMP 3578
## Neuregulin-3 / NRG3 3698
## Neurturin 4998
## NGF R / TNFRSF16 5357
## NOV / CCN3 7780
## Osteoactivin / GPNMB 22090
## Osteopontin 15341
## Osteoporotegerin 13722
## OX40 Ligand / TNFSF4 8420
## PDGF C 14816
## PDGF R alpha 7124
## PDGF R beta 12910
## Pentraxin3 / TSG-14 21116
## PF-4 26969
## PlGF-2 8660
## Progranulin 28661
## Prolactin 33334
## P-Selectin 8842
## RAGE 13140
## RANTES 17797
## RELM beta 30028
## Resistin 6871
## S100A10 4234
## SCF 2588
## SCF R / c-kit 11108
## SDF-1 5432
## Serum Amyloid A1 5743
## Shh-N 13421
## SIGIRR 12832
## SLPI 15977
## Soggy-1 15561
## SPARC 30355
## Spinesin Ectodomain 4399
## TACI / TNFRSF13B 8147
## TARC 12827
## TCA-3 14885
## TCCR / WSX-1 10484
## TECK 8635
## TFPI 4421
## TGF-beta 1 9359
## TGF-beta 2 0
## TGF-beta 3 6434
## TGF-beta RI / ALK-5 3065
## TGF-beta RII 82000
## Thrombospondin 570
## Thymus Chemokine-1 14824
## Tie-2 4134
## TIMP-1Â 3342
## TIMP-2 41575
## TIMP-4 5996
## TL1A / TNFSF15 6678
## TLR1 2876
## TLR2 86148
## TLR3 3246
## TLR4 9550
## TMEFF1 / Tomoregulin-1 5045
## TNF RI / TNFRSF1A 7189
## TNF RII 8815
## TNF-alpha 3510
## TNF-beta / TNFSF1B 17760
## TPO 7416
## TRAIL / TNFSF10 29810
## TRAIL R2 / TNFRSF10B 7091
## TRANCE / TNFSF11 8382
## TREM-1 4334
## TROY 3672
## TSLP 7615
## TSLP R 16019
## TWEAK / TNFSF12 11482
## TWEAK R / TNFRSF12 14579
## Ubiqultin 1717
## uPAR 6932
## Urokinase 12878
## VCAM-1 17481
## VE-Cadherin 17554
## VEGF 1963
## VEGF R1 1942
## VEGF R2 9273
## VEGF R3 5347
## VEGF-B 25688
## VEGFC 66436
## VEGF-D 5169
## WIF-1 2254
## WISP-1 / CCN4 18663Using the group mean to redo the analysis
for(dd_m in c("euclidean", "maximum", "manhattan", "canberra", "binary", "minkowski")){
for (hc_m in c("ward.D", "ward.D2", "single", "complete", "average", "mcquitty", "median", "centroid")){
dd <- dist(t(temp_df_mean), method = dd_m)
hc <- hclust(dd, method = hc_m)
plot(hc, labels = NULL, hang = 0.1,
main = paste("Biomarker", dd_m, hc_m), sub = NULL,
xlab = NULL, ylab = NULL)
}
}
library("gplots")
hclustfunc <- function(x) hclust(x, method="complete")
distfunc <- function(x) dist(x,method="binary")
heatmap.2(t(temp_df_mean), scale='column', dendrogram="row",trace="none", margin=c(8,9),hclust=hclustfunc,distfun=distfunc);