When analyzing health data, it is very important to define control groups. The definition of control groups can be quite challenging and often times a limitation for large-scale data mining projects.
Let’s say that we want to analyze a set of observations for patients with end stage kidney disease with the goal of establishing an early diagnosis.
We may want to know what type of observations are more often found in this population. In order to do this analysis, we need a good control group, preferable composed of precursors or populations that may be at a high risk for developing the disease of interest.
The purpose of this project is to build a database of diseases and other related diseases by scraping a well-known clinical-literature search engine such as PubMed.
The assumption is that if a publication contains references to conditions A and B, there may be a relationship between these two. If the above it is true for a large number of publications, it may suggest that the disease combination could be a good candidate for further analysis.
We will use disease terms found in ICD9 classification data.
The goal is to obtain frequency counts of: * Individual disease terms: Diabetes, Cancer, HIV, etc. * All disease terms combinations: Diabetes AND Cancer, Diabetes AND HIV, etc.
library(RCurl)
library(XML)
library(rvest)
library(knitr)
library(plyr)
library(stringr)
library(rmongodb)
library(rjson)
library(tm)The Healthcare Utilization Project (HCUP) has an ICD9 classification data available in their website.
There is one file in particular that contains diagnosis category names. This list is great as the disease labels are in plain english.
A CSV version of this file is available in the Single-Level Diagnosis CCS Categories. This is the data that we will use as our list of diseases.
# get files diagnosis category label from CSV in github
dxref <- "https://raw.githubusercontent.com/rmalarc/is607/master/final_project/Single_Level_CCS_2015/dxlabel%202013.csv"
dxref_data_csv <- getURL(dxref)
dxref_data <- read.csv(text=dxref_data_csv,head=TRUE,sep=",",as.is=TRUE)
#clean up column names and turn to lower_case
colnames(dxref_data)<-tolower(gsub("\\.","_",colnames(dxref_data)))
kable(summary(dxref_data))| ccs_diagnosis_categories | ccs_diagnosis_categories_labels | |
|---|---|---|
| Length:288 | Length:288 | |
| Class :character | Class :character | |
| Mode :character | Mode :character |
kable(head(dxref_data,n=25))| ccs_diagnosis_categories | ccs_diagnosis_categories_labels |
|---|---|
| .Z | Overall |
| . | No diagnosis |
| .A | Invalid diagnosis |
| 1 | Tuberculosis |
| 2 | Septicemia (except in labor) |
| 3 | Bacterial infection; unspecified site |
| 4 | Mycoses |
| 5 | HIV infection |
| 6 | Hepatitis |
| 7 | Viral infection |
| 8 | Other infections; including parasitic |
| 9 | Sexually transmitted infections (not HIV or hepatitis) |
| 10 | Immunizations and screening for infectious disease |
| 11 | Cancer of head and neck |
| 12 | Cancer of esophagus |
| 13 | Cancer of stomach |
| 14 | Cancer of colon |
| 15 | Cancer of rectum and anus |
| 16 | Cancer of liver and intrahepatic bile duct |
| 17 | Cancer of pancreas |
| 18 | Cancer of other GI organs; peritoneum |
| 19 | Cancer of bronchus; lung |
| 20 | Cancer; other respiratory and intrathoracic |
| 21 | Cancer of bone and connective tissue |
| 22 | Melanomas of skin |
In order to use the disease terms we need to:
# flag those terms that appear to be invalid
dxref_data$is_valid <- TRUE
dxref_data[dxref_data$ccs_diagnosis_categories %in%
c(".Z ",". ",".A ","254","255","256","257","258","259"),"is_valid"] <-FALSE
dxref_data[grep("E Codes: ",dxref_data$ccs_diagnosis_categories_labels),"is_valid"] <-FALSE
# gsub helper function
toString <- content_transformer(function(x, from, to) gsub(from, to, x))
#load data into corpus
dxref_data_corpus <- Corpus(VectorSource(dxref_data[2]))
#remove numbers
dxref_data_corpus <- tm_map(dxref_data_corpus, removeNumbers)
# to lowercase
dxref_data_corpus <- tm_map(dxref_data_corpus, content_transformer(tolower))
# Hyphens to spaces
dxref_data_corpus <- tm_map(dxref_data_corpus, toString, "-", " ")
# remove the stuff in parentesis
dxref_data_corpus <- tm_map(dxref_data_corpus, toString, "\\(.+\\)", "")
# replace / or - for whitespace
dxref_data_corpus <- tm_map(dxref_data_corpus, toString, "(/|-)", " ")
#remove punctuation
dxref_data_corpus <- tm_map(dxref_data_corpus, removePunctuation)
# remove english stop words
dxref_data_corpus <- tm_map(dxref_data_corpus, removeWords, stopwords("english"))
# strip double white spaces
dxref_data_corpus <- tm_map(dxref_data_corpus, toString, "^\\s+|\\s+$", "")
dxref_data_corpus <- tm_map(dxref_data_corpus, toString, " ", " ")
dxref_data_corpus <- tm_map(dxref_data_corpus, stripWhitespace)
# merge with dataframe
dxref_data$disease_phrase <- dxref_data_corpus[["1"]][["content"]]
dxref_data$disease_phrase <- gsub(" "," AND ",dxref_data$disease_phrase)
dxref_data$url_params <- sapply(dxref_data$disease_phrase,URLencode)In order to facilitate scraping more than one page, we will use the following functions:
####################################################################################
# pubmed_entries_for(URLParams)
#
# This function scrapes pubmed by searching for the specified URL encoded keyword.
# The function returns the number of entries in pubmed for the keyword.
####################################################################################
pubmed_entries_for <-function(URLParams) {
Sys.sleep(0.5)
baseURL <- "http://www.ncbi.nlm.nih.gov/pubmed?term="
theURL <- paste(baseURL,URLParams,sep="")
page_data <- html(theURL)
pubmed_results<- page_data %>%
html_nodes(xpath='//h2[contains(@class,"result_count")]')
pubmed_results<- sapply(pubmed_results,xmlValue)
if(length(pubmed_results) > 0){
pubmed_results<-as.integer(str_extract(pubmed_results[1],"[0-9]+$"))
} else {
pubmed_results <- 0
}
return(pubmed_results)
}
####################################################################################
# scrape_pubmed_entries(ref_data, entry_type)
#
# This function accepts a dataframe containing the entries to process as well as an entry_type.
# The DF must contain a column called url_params, which are the URL parameters passed to
# pubmed_entries_for.
#
# The processed output is saved to MongoDB and returned as a dataframe
####################################################################################
scrape_pubmed_entries <- function(ref_data,entry_type) {
#ref_data<-dxref_data_x_join
#entry_type<-"intersect_count"
coll<-paste(ns,entry_type,sep=".")
# get previously exported records
entries_processed <- NULL
cursor<-mongo.find(m
,coll
,query = mongo.bson.empty()
,fields=list(url_params=1L)
)
entries_processed <- mongo.cursor.to.data.frame(cursor)
mongo.cursor.destroy(cursor)
# process records not already processed
entries_to_process <- ref_data[!(ref_data$url_params %in% entries_processed$url_params),]
if(nrow(entries_to_process)>0){
for (i in 1:nrow(entries_to_process)){
entry<-entries_to_process[i,]
# get the number of hits for entry in pubmed
hits<-pubmed_entries_for(entry$url_params)
# resulting DF
results<-entry
results$entry_type <- entry_type
results$hits<-hits
# export to mongo
mongo.insert(m, coll,mongo.bson.from.JSON(toJSON(results)))
}
}
# get all processed entries
cursor <- mongo.find(m
,coll
,query = mongo.bson.empty()
)
entries_processed <- mongo.cursor.to.data.frame(cursor)
mongo.cursor.destroy(cursor)
return(entries_processed)
}# connect to monogo so we can export the results of the scrape a row at a time
m <- mongo.create()
ns <- "scrape_pubmed"
# yes, it's a loop. The apply functions are faster. However, the function gets delayed by a sec
# each time. The loop allows me to restart where I left off
entries_processed <- NULL
# If you want to restart the whole process from scratch, set restart to TRUE
restart <- FALSE
if (restart){
#delete all previously processed entries by purging the contents of the MongoDB
mongo.remove(m, ns)
}
absolute_count_entries_processed <- scrape_pubmed_entries(dxref_data[dxref_data$is_valid,],"absolute_count")## Warning in mongo.cursor.to.data.frame(cursor): This fails for most NoSQL
## data structures. I am working on a new solution## Warning in mongo.cursor.to.data.frame(cursor): This fails for most NoSQL
## data structures. I am working on a new solution# show a sample of the output
#kable(head(absolute_count_entries_processed,n=25))# x-join all the VALID terms
dxref_data_x_join <- merge(x = absolute_count_entries_processed[absolute_count_entries_processed$is_valid&(absolute_count_entries_processed$hits>0),]
, y = absolute_count_entries_processed[absolute_count_entries_processed$is_valid&(absolute_count_entries_processed$hits>0),]
, by = NULL)
dxref_data_x_join$ccs_diagnosis_categories.x<-as.character(dxref_data_x_join$ccs_diagnosis_categories.x)
dxref_data_x_join$ccs_diagnosis_categories.y<-as.character(dxref_data_x_join$ccs_diagnosis_categories.y)
#Remove permutations, we just want combinations
dxref_data_x_join <- dxref_data_x_join[dxref_data_x_join$ccs_diagnosis_categories.x
>dxref_data_x_join$ccs_diagnosis_categories.y,]
# generate combined URL parameters
dxref_data_x_join$url_params <- sprintf("(%s)AND(%s)",dxref_data_x_join$url_params.x,dxref_data_x_join$url_params.y)
#scrape pubmed
intersect_count_entries_processed <- scrape_pubmed_entries(dxref_data_x_join,"intersect_count")## Warning in mongo.cursor.to.data.frame(cursor): This fails for most NoSQL
## data structures. I am working on a new solution## Warning in mongo.cursor.to.data.frame(cursor): This fails for most NoSQL
## data structures. I am working on a new solution#show a sample of the output
#kable(head(intersect_count_entries_processed,n=25))# Estimate the total number of UNIQUE documents
total_number_of_documents<-sum(absolute_count_entries_processed[absolute_count_entries_processed$is_valid,"hits"])*0.5
absolute_count_entries_processed$p_hit <- absolute_count_entries_processed$hits/total_number_of_documents
kable(
absolute_count_entries_processed[
order(-absolute_count_entries_processed$p_hit)
,c("ccs_diagnosis_categories_labels"
,"hits"
,"p_hit"
)
]
)| ccs_diagnosis_categories_labels | hits | p_hit | |
|---|---|---|---|
| 101 | Secondary malignancies | 325763 | 0.0790043 |
| 83 | Cancer of breast | 299830 | 0.0727150 |
| 208 | Other liver diseases | 281580 | 0.0682890 |
| 98 | Leukemias | 267744 | 0.0649335 |
| 66 | Viral infection | 224547 | 0.0544573 |
| 60 | Tuberculosis | 218038 | 0.0528788 |
| 236 | Other complications of pregnancy | 208181 | 0.0504882 |
| 65 | Hepatitis | 204240 | 0.0495325 |
| 7 | Shock | 193997 | 0.0470483 |
| 2 | Other fractures | 186569 | 0.0452469 |
| 112 | Disorders of lipid metabolism | 154206 | 0.0373982 |
| 14 | Asthma | 149683 | 0.0363012 |
| 166 | Cardiac dysrhythmias | 148992 | 0.0361337 |
| 255 | Other skin disorders | 145285 | 0.0352346 |
| 61 | Septicemia (except in labor) | 144864 | 0.0351325 |
| 131 | Mood disorders | 138547 | 0.0336005 |
| 155 | Other nervous system disorders | 127493 | 0.0309197 |
| 181 | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 121027 | 0.0293516 |
| 64 | HIV infection | 120652 | 0.0292606 |
| 31 | Other congenital anomalies | 114634 | 0.0278011 |
| 88 | Cancer of prostate | 111998 | 0.0271618 |
| 63 | Mycoses | 106738 | 0.0258862 |
| 132 | Personality disorders | 103325 | 0.0250585 |
| 11 | Other eye disorders | 97891 | 0.0237406 |
| 72 | Cancer of stomach | 97866 | 0.0237345 |
| 116 | Immunity disorders | 96838 | 0.0234852 |
| 109 | Diabetes mellitus with complications | 95897 | 0.0232570 |
| 145 | Paralysis | 94899 | 0.0230150 |
| 135 | Substance-related disorders | 89479 | 0.0217005 |
| 73 | Cancer of colon | 89012 | 0.0215873 |
| 212 | Other gastrointestinal disorders | 86766 | 0.0210426 |
| 125 | Anxiety disorders | 84296 | 0.0204435 |
| 13 | Influenza | 82401 | 0.0199840 |
| 70 | Cancer of head and neck | 79464 | 0.0192717 |
| 3 | Burns | 79321 | 0.0192370 |
| 124 | Adjustment disorders | 76870 | 0.0186426 |
| 110 | Other endocrine disorders | 76097 | 0.0184551 |
| 160 | Acute myocardial infarction | 75580 | 0.0183297 |
| 146 | Epilepsy; convulsions | 74235 | 0.0180035 |
| 8 | Abdominal pain | 73058 | 0.0177181 |
| 177 | Other circulatory disease | 68297 | 0.0165634 |
| 215 | Chronic kidney disease | 67379 | 0.0163408 |
| 91 | Cancer of bladder | 67232 | 0.0163052 |
| 20 | Osteoporosis | 66792 | 0.0161984 |
| 143 | Multiple sclerosis | 64345 | 0.0156050 |
| 139 | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | 64255 | 0.0155832 |
| 128 | Developmental disorders | 63644 | 0.0154350 |
| 95 | Cancer of thyroid | 61217 | 0.0148464 |
| 17 | Osteoarthritis | 60180 | 0.0145949 |
| 9 | Cataract | 59265 | 0.0143730 |
| 142 | Parkinson`s disease | 58753 | 0.0142488 |
| 163 | Pulmonary heart disease | 57407 | 0.0139224 |
| 140 | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | 56978 | 0.0138184 |
| 209 | Pancreatic disorders (not diabetes) | 56567 | 0.0137187 |
| 10 | Glaucoma | 55934 | 0.0135652 |
| 40 | Spinal cord injury | 54963 | 0.0133297 |
| 216 | Urinary tract infections | 50975 | 0.0123625 |
| 192 | Intestinal infection | 49620 | 0.0120339 |
| 229 | Female infertility | 48658 | 0.0118006 |
| 107 | Thyroid disorders | 46563 | 0.0112925 |
| 134 | Alcohol-related disorders | 44263 | 0.0107347 |
| 210 | Gastrointestinal hemorrhage | 42753 | 0.0103685 |
| 115 | Cystic fibrosis | 41838 | 0.0101466 |
| 96 | Hodgkin`s disease | 41421 | 0.0100455 |
| 99 | Multiple myeloma | 39536 | 0.0095883 |
| 76 | Cancer of pancreas | 39050 | 0.0094704 |
| 86 | Cancer of ovary | 38879 | 0.0094290 |
| 81 | Melanomas of skin | 37949 | 0.0092034 |
| 85 | Cancer of cervix | 35741 | 0.0086679 |
| 156 | Heart valve disorders | 35141 | 0.0085224 |
| 35 | Respiratory distress syndrome | 35068 | 0.0085047 |
| 84 | Cancer of uterus | 35012 | 0.0084911 |
| 68 | Sexually transmitted infections (not HIV or hepatitis) | 34651 | 0.0084036 |
| 57 | Nausea and vomiting | 32254 | 0.0078223 |
| 195 | Esophageal disorders | 30891 | 0.0074917 |
| 71 | Cancer of esophagus | 30396 | 0.0073717 |
| 118 | Deficiency and other anemia | 29922 | 0.0072567 |
| 158 | Essential hypertension | 28583 | 0.0069320 |
| 233 | Induced abortion | 28317 | 0.0068675 |
| 21 | Pathological fracture | 25290 | 0.0061334 |
| 23 | Other acquired deformities | 22528 | 0.0054635 |
| 50 | Complications of surgical procedures or medical care | 22096 | 0.0053587 |
| 165 | Conduction disorders | 21708 | 0.0052646 |
| 15 | Endometriosis | 21526 | 0.0052205 |
| 59 | Allergic reactions | 20598 | 0.0049954 |
| 120 | Sickle cell anemia | 20104 | 0.0048756 |
| 232 | Spontaneous abortion | 19546 | 0.0047403 |
| 97 | Non-Hodgkin`s lymphoma | 19134 | 0.0046404 |
| 45 | Intracranial injury | 18736 | 0.0045439 |
| 228 | Menopausal disorders | 18449 | 0.0044743 |
| 190 | Other lower respiratory disease | 17467 | 0.0042361 |
| 94 | Cancer of brain and nervous system | 17424 | 0.0042257 |
| 25 | Other connective tissue disease | 17077 | 0.0041415 |
| 4 | Syncope | 16672 | 0.0040433 |
| 161 | Coronary atherosclerosis and other heart disease | 16308 | 0.0039550 |
| 89 | Cancer of testis | 16100 | 0.0039046 |
| 221 | Hyperplasia of prostate | 16097 | 0.0039039 |
| 133 | Schizophrenia and other psychotic disorders | 15867 | 0.0038481 |
| 44 | Sprains and strains | 15255 | 0.0036997 |
| 16 | Ovarian cyst | 15249 | 0.0036982 |
| 235 | Ectopic pregnancy | 15019 | 0.0036424 |
| 230 | Other female genital disorders | 14107 | 0.0034212 |
| 200 | Abdominal hernia | 14062 | 0.0034103 |
| 6 | Gangrene | 13925 | 0.0033771 |
| 253 | Other inflammatory condition of skin | 13804 | 0.0033478 |
| 5 | Lymphadenitis | 13792 | 0.0033448 |
| 172 | Transient cerebral ischemia | 13531 | 0.0032815 |
| 251 | Normal pregnancy and/or delivery | 12867 | 0.0031205 |
| 227 | Menstrual disorders | 12599 | 0.0030555 |
| 184 | Other upper respiratory infections | 12420 | 0.0030121 |
| 29 | Genitourinary congenital anomalies | 11812 | 0.0028647 |
| 240 | Prolonged pregnancy | 11626 | 0.0028195 |
| 1 | Birth trauma | 11058 | 0.0026818 |
| 122 | Diseases of white blood cells | 10273 | 0.0024914 |
| 191 | Other upper respiratory disease | 9213 | 0.0022343 |
| 28 | Digestive congenital anomalies | 9122 | 0.0022123 |
| 78 | Cancer of bronchus; lung | 8894 | 0.0021570 |
| 53 | Poisoning by other medications and drugs | 8775 | 0.0021281 |
| 159 | Hypertension with complications and secondary hypertension | 8747 | 0.0021213 |
| 127 | Delirium, dementia, and amnestic and other cognitive disorders | 8506 | 0.0020629 |
| 67 | Other infections; including parasitic | 8309 | 0.0020151 |
| 52 | Poisoning by psychotropic agents | 8256 | 0.0020023 |
| 223 | Other male genital disorders | 7911 | 0.0019186 |
| 206 | Biliary tract disease | 7246 | 0.0017573 |
| 169 | Acute cerebrovascular disease | 6958 | 0.0016875 |
| 167 | Cardiac arrest and ventricular fibrillation | 6736 | 0.0016336 |
| 39 | Fracture of neck of femur (hip) | 6386 | 0.0015487 |
| 183 | Acute bronchitis | 6384 | 0.0015483 |
| 196 | Gastroduodenal ulcer (except hemorrhage) | 6022 | 0.0014605 |
| 123 | Other hematologic conditions | 5703 | 0.0013831 |
| 12 | Hemorrhoids | 5684 | 0.0013785 |
| 75 | Cancer of liver and intrahepatic bile duct | 5622 | 0.0013635 |
| 56 | Fever of unknown origin | 5497 | 0.0013331 |
| 217 | Calculus of urinary tract | 5393 | 0.0013079 |
| 257 | Rheumatoid arthritis and related disease | 5312 | 0.0012883 |
| 114 | Fluid and electrolyte disorders | 5132 | 0.0012446 |
| 111 | Nutritional deficiencies | 4692 | 0.0011379 |
| 218 | Other diseases of kidney and ureters | 4008 | 0.0009720 |
| 151 | Inflammation; infection of eye (except that caused by tuberculosis or sexually transmitteddisease) | 3967 | 0.0009621 |
| 43 | Fracture of lower limb | 3668 | 0.0008896 |
| 121 | Coagulation and hemorrhagic disorders | 3557 | 0.0008626 |
| 30 | Nervous system congenital anomalies | 3429 | 0.0008316 |
| 37 | Other perinatal conditions | 3236 | 0.0007848 |
| 254 | Chronic ulcer of skin | 3217 | 0.0007802 |
| 193 | Disorders of teeth and jaw | 3003 | 0.0007283 |
| 93 | Cancer of other urinary organs | 3000 | 0.0007276 |
| 249 | Forceps delivery | 2983 | 0.0007234 |
| 219 | Other diseases of bladder and urethra | 2866 | 0.0006951 |
| 138 | Miscellaneous disorders | 2839 | 0.0006885 |
| 92 | Cancer of kidney and renal pelvis | 2820 | 0.0006839 |
| 198 | Other disorders of stomach and duodenum | 2807 | 0.0006808 |
| 207 | Liver disease; alcohol-related | 2734 | 0.0006631 |
| 74 | Cancer of rectum and anus | 2656 | 0.0006441 |
| 22 | Acquired foot deformities | 2544 | 0.0006170 |
| 126 | Attention-deficit, conduct, and disruptive behavior disorders | 2486 | 0.0006029 |
| 24 | Systemic lupus erythematosus and connective tissue disorders | 2479 | 0.0006012 |
| 178 | Phlebitis; thrombophlebitis and thromboembolism | 2411 | 0.0005847 |
| 82 | Other non-epithelial cancer of skin | 2392 | 0.0005801 |
| 105 | Benign neoplasm of uterus | 2194 | 0.0005321 |
| 203 | Diverticulosis and diverticulitis | 2037 | 0.0004940 |
| 48 | Open wounds of extremities | 2028 | 0.0004918 |
| 32 | Liveborn | 1955 | 0.0004741 |
| 42 | Fracture of upper limb | 1860 | 0.0004511 |
| 179 | Varicose veins of lower extremity | 1750 | 0.0004244 |
| 252 | Skin and subcutaneous tissue infections | 1665 | 0.0004038 |
| 27 | Cardiac and circulatory congenital anomalies | 1490 | 0.0003614 |
| 244 | Previous C-section | 1475 | 0.0003577 |
| 69 | Immunizations and screening for infectious disease | 1465 | 0.0003553 |
| 150 | Blindness and vision defects | 1465 | 0.0003553 |
| 234 | Postabortion complications | 1445 | 0.0003504 |
| 80 | Cancer of bone and connective tissue | 1402 | 0.0003400 |
| 147 | Headache; including migraine | 1394 | 0.0003381 |
| 41 | Skull and face fractures | 1340 | 0.0003250 |
| 104 | Maintenance chemotherapy; radiotherapy | 1315 | 0.0003189 |
| 180 | Other diseases of veins and lymphatics | 1254 | 0.0003041 |
| 197 | Gastritis and duodenitis | 1162 | 0.0002818 |
| 87 | Cancer of other female genital organs | 998 | 0.0002420 |
| 205 | Peritonitis and intestinal abscess | 771 | 0.0001870 |
| 58 | Malaise and fatigue | 682 | 0.0001654 |
| 185 | Chronic obstructive pulmonary disease and bronchiectasis | 668 | 0.0001620 |
| 113 | Gout and other crystal arthropathies | 625 | 0.0001516 |
| 18 | Other non-traumatic joint disorders | 542 | 0.0001314 |
| 162 | Nonspecific chest pain | 447 | 0.0001084 |
| 117 | Other nutritional; endocrine; and metabolic disorders | 446 | 0.0001082 |
| 90 | Cancer of other male genital organs | 386 | 0.0000936 |
| 26 | Other bone disease and musculoskeletal deformities | 338 | 0.0000820 |
| 182 | Acute and chronic tonsillitis | 322 | 0.0000781 |
| 79 | Cancer; other respiratory and intrathoracic | 317 | 0.0000769 |
| 204 | Anal and rectal conditions | 314 | 0.0000762 |
| 173 | Late effects of cerebrovascular disease | 312 | 0.0000757 |
| 247 | Umbilical cord complication | 300 | 0.0000728 |
| 188 | Respiratory failure; insufficiency; arrest (adult) | 293 | 0.0000711 |
| 164 | Other and ill-defined heart disease | 285 | 0.0000691 |
| 38 | Joint disorders and dislocations; trauma-related | 278 | 0.0000674 |
| 225 | Inflammatory diseases of female pelvic organs | 222 | 0.0000538 |
| 49 | Complication of device; implant or graft | 211 | 0.0000512 |
| 100 | Cancer; other and unspecified primary | 208 | 0.0000504 |
| 213 | Nephritis; nephrosis; renal sclerosis | 203 | 0.0000492 |
| 201 | Regional enteritis and ulcerative colitis | 188 | 0.0000456 |
| 239 | Early or threatened labor | 172 | 0.0000417 |
| 237 | Hemorrhage during pregnancy; abruptio placenta; placenta previa | 143 | 0.0000347 |
| 154 | Other ear and sense organ disorders | 140 | 0.0000340 |
| 176 | Aortic and peripheral arterial embolism or thrombosis | 138 | 0.0000335 |
| 51 | Superficial injury; contusion | 124 | 0.0000301 |
| 152 | Otitis media and related conditions | 119 | 0.0000289 |
| 33 | Short gestation; low birth weight; and fetal growth retardation | 103 | 0.0000250 |
| 141 | Other CNS infection and poliomyelitis | 103 | 0.0000250 |
| 129 | Disorders usually diagnosed in infancy, childhood, or adolescence | 98 | 0.0000238 |
| 153 | Conditions associated with dizziness or vertigo | 95 | 0.0000230 |
| 211 | Noninfectious gastroenteritis | 92 | 0.0000223 |
| 34 | Intrauterine hypoxia and birth asphyxia | 82 | 0.0000199 |
| 174 | Peripheral and visceral atherosclerosis | 81 | 0.0000196 |
| 106 | Other and unspecified benign neoplasm | 80 | 0.0000194 |
| 224 | Nonmalignant breast conditions | 78 | 0.0000189 |
| 256 | Infective arthritis and osteomyelitis (except that caused by tuberculosis or sexually transmitted disease) | 78 | 0.0000189 |
| 175 | Aortic; peripheral; and visceral artery aneurysms | 68 | 0.0000165 |
| 242 | Malposition; malpresentation | 67 | 0.0000162 |
| 171 | Other and ill-defined cerebrovascular disease | 66 | 0.0000160 |
| 199 | Appendicitis and other appendiceal conditions | 59 | 0.0000143 |
| 226 | Prolapse of female genital organs | 50 | 0.0000121 |
| 194 | Diseases of mouth; excluding dental | 48 | 0.0000116 |
| 46 | Crushing injury or internal injury | 43 | 0.0000104 |
| 119 | Acute posthemorrhagic anemia | 31 | 0.0000075 |
| 47 | Open wounds of head; neck; and trunk | 30 | 0.0000073 |
| 136 | Suicide and intentional self-inflicted injury | 23 | 0.0000056 |
| 220 | Genitourinary symptoms and ill-defined conditions | 19 | 0.0000046 |
| 36 | Hemolytic jaundice and perinatal jaundice | 18 | 0.0000044 |
| 214 | Acute and unspecified renal failure | 16 | 0.0000039 |
| 144 | Other hereditary and degenerative nervous system conditions | 13 | 0.0000032 |
| 148 | Coma; stupor; and brain damage | 13 | 0.0000032 |
| 19 | Spondylosis; intervertebral disc disorders; other back problems | 10 | 0.0000024 |
| 77 | Cancer of other GI organs; peritoneum | 8 | 0.0000019 |
| 187 | Pleurisy; pneumothorax; pulmonary collapse | 6 | 0.0000015 |
| 231 | Contraceptive and procreative management | 6 | 0.0000015 |
| 168 | Congestive heart failure; nonhypertensive | 5 | 0.0000012 |
| 170 | Occlusion or stenosis of precerebral arteries | 5 | 0.0000012 |
| 149 | Retinal detachments; defects; vascular occlusion; and retinopathy | 4 | 0.0000010 |
| 222 | Inflammatory conditions of male genital organs | 3 | 0.0000007 |
| 62 | Bacterial infection; unspecified site | 2 | 0.0000005 |
| 186 | Aspiration pneumonitis; food/vomitus | 2 | 0.0000005 |
| 250 | Other complications of birth; puerperium affecting management of mother | 2 | 0.0000005 |
| 54 | Poisoning by nonmedicinal substances | 0 | 0.0000000 |
| 55 | Other injuries and conditions due to external causes | 0 | 0.0000000 |
| 102 | Malignant neoplasm without specification of site | 0 | 0.0000000 |
| 103 | Neoplasms of unspecified nature or uncertain behavior | 0 | 0.0000000 |
| 108 | Diabetes mellitus without complication | 0 | 0.0000000 |
| 130 | Impulse control disorders, NEC | 0 | 0.0000000 |
| 137 | Screening and history of mental health and substance abuse codes | 0 | 0.0000000 |
| 157 | Peri-; endo-; and myocarditis; cardiomyopathy (except that caused by tuberculosis or sexually transmitted disease) | 0 | 0.0000000 |
| 189 | Lung disease due to external agents | 0 | 0.0000000 |
| 202 | Intestinal obstruction without hernia | 0 | 0.0000000 |
| 238 | Hypertension complicating pregnancy; childbirth and the puerperium | 0 | 0.0000000 |
| 241 | Diabetes or abnormal glucose tolerance complicating pregnancy; childbirth; or the puerperium | 0 | 0.0000000 |
| 243 | Fetopelvic disproportion; obstruction | 0 | 0.0000000 |
| 245 | Fetal distress and abnormal forces of labor | 0 | 0.0000000 |
| 246 | Polyhydramnios and other problems of amniotic cavity | 0 | 0.0000000 |
| 248 | OB-related trauma to perineum and vulva | 0 | 0.0000000 |
summary<-intersect_count_entries_processed[c("ccs_diagnosis_categories_labels.x"
,"ccs_diagnosis_categories_labels.y"
,"url_params"
,"hits.x"
,"hits.y"
,"hits")]
summary$p_intersect_given_xy<-summary$hits/(summary$hits.x+summary$hits.y)
summary$p_intersect<-summary$hits/total_number_of_documents
kable(
head(
summary[
order(-summary$p_intersect)
,c("ccs_diagnosis_categories_labels.x"
,"ccs_diagnosis_categories_labels.y"
,"hits.x"
,"hits.y"
,"hits"
,"p_intersect_given_xy"
,"p_intersect"
)
]
,n=500
)
)| ccs_diagnosis_categories_labels.x | ccs_diagnosis_categories_labels.y | hits.x | hits.y | hits | p_intersect_given_xy | p_intersect | |
|---|---|---|---|---|---|---|---|
| 16413 | Hepatitis | Other liver diseases | 204207 | 281545 | 51249 | 0.1055045 | 0.0124289 |
| 3084 | Secondary malignancies | Cancer of breast | 325699 | 299768 | 49843 | 0.0796893 | 0.0120880 |
| 519 | Viral infection | HIV infection | 224492 | 120631 | 46126 | 0.1336509 | 0.0111865 |
| 573 | Viral infection | Hepatitis | 224492 | 204207 | 39672 | 0.0925405 | 0.0096213 |
| 376 | Shock | Septicemia (except in labor) | 193946 | 144834 | 30269 | 0.0893471 | 0.0073409 |
| 5648 | Substance-related disorders | Alcohol-related disorders | 89475 | 44257 | 23367 | 0.1747301 | 0.0056670 |
| 24243 | Other fractures | Osteoporosis | 186529 | 66779 | 20930 | 0.0826267 | 0.0050760 |
| 24371 | Other fractures | Pathological fracture | 186529 | 25288 | 19753 | 0.0932550 | 0.0047905 |
| 4037 | Non-Hodgkin`s lymphoma | Hodgkin`s disease | 19130 | 41418 | 18830 | 0.3109929 | 0.0045667 |
| 16451 | Disorders of lipid metabolism | Other liver diseases | 154188 | 281545 | 17292 | 0.0396849 | 0.0041937 |
| 16443 | Secondary malignancies | Other liver diseases | 325699 | 281545 | 16657 | 0.0274305 | 0.0040397 |
| 1392 | Secondary malignancies | Cancer of stomach | 325699 | 97846 | 16543 | 0.0390584 | 0.0040120 |
| 5385 | Personality disorders | Anxiety disorders | 103317 | 84284 | 16371 | 0.0872650 | 0.0039703 |
| 3979 | Thyroid disorders | Cancer of thyroid | 46553 | 61207 | 16135 | 0.1497309 | 0.0039131 |
| 5384 | Mood disorders | Anxiety disorders | 138517 | 84284 | 15666 | 0.0703139 | 0.0037993 |
| 4589 | Other endocrine disorders | Thyroid disorders | 76089 | 46553 | 15400 | 0.1255687 | 0.0037348 |
| 11237 | Viral infection | Influenza | 224492 | 82385 | 15237 | 0.0496518 | 0.0036953 |
| 3485 | Secondary malignancies | Cancer of prostate | 325699 | 111972 | 14644 | 0.0334589 | 0.0035515 |
| 16414 | Viral infection | Other liver diseases | 224492 | 281545 | 14350 | 0.0283576 | 0.0034802 |
| 5348 | Personality disorders | Adjustment disorders | 103317 | 76856 | 13870 | 0.0769816 | 0.0033638 |
| 3071 | Cancer of prostate | Cancer of breast | 111972 | 299768 | 13751 | 0.0333973 | 0.0033349 |
| 949 | Secondary malignancies | Cancer of head and neck | 325699 | 79442 | 13506 | 0.0333365 | 0.0032755 |
| 23150 | Other skin disorders | Other inflammatory condition of skin | 145255 | 13801 | 13104 | 0.0823861 | 0.0031780 |
| 3159 | Cancer of cervix | Cancer of uterus | 35740 | 35011 | 12206 | 0.1725205 | 0.0029602 |
| 1597 | Secondary malignancies | Cancer of colon | 325699 | 88995 | 11852 | 0.0285801 | 0.0028744 |
| 25339 | Other congenital anomalies | Genitourinary congenital anomalies | 114619 | 11812 | 11812 | 0.0934265 | 0.0028647 |
| 5555 | Personality disorders | Mood disorders | 103317 | 138517 | 11371 | 0.0470199 | 0.0027577 |
| 521 | Sexually transmitted infections (not HIV or hepatitis) | HIV infection | 34644 | 120631 | 11323 | 0.0729222 | 0.0027461 |
| 518 | Hepatitis | HIV infection | 204207 | 120631 | 11252 | 0.0346388 | 0.0027288 |
| 3975 | Secondary malignancies | Cancer of thyroid | 325699 | 61207 | 10987 | 0.0283971 | 0.0026646 |
| 16867 | Other gastrointestinal disorders | Gastrointestinal hemorrhage | 86745 | 42743 | 10898 | 0.0841622 | 0.0026430 |
| 11020 | Mycoses | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 106711 | 121004 | 10542 | 0.0462947 | 0.0025567 |
| 5589 | Substance-related disorders | Personality disorders | 89475 | 103317 | 10485 | 0.0543850 | 0.0025428 |
| 1579 | Cancer of breast | Cancer of colon | 299768 | 88995 | 10418 | 0.0267978 | 0.0025266 |
| 4997 | Viral infection | Immunity disorders | 224492 | 96804 | 10179 | 0.0316811 | 0.0024686 |
| 2309 | Secondary malignancies | Melanomas of skin | 325699 | 37939 | 9791 | 0.0269251 | 0.0023745 |
| 16502 | Other gastrointestinal disorders | Other liver diseases | 86745 | 281545 | 9648 | 0.0261967 | 0.0023398 |
| 4170 | Secondary malignancies | Leukemias | 325699 | 267725 | 9618 | 0.0162076 | 0.0023326 |
| 16602 | Cancer of pancreas | Pancreatic disorders (not diabetes) | 39043 | 56562 | 9599 | 0.1004027 | 0.0023280 |
| 4 | HIV infection | Tuberculosis | 120631 | 218021 | 9596 | 0.0283359 | 0.0023272 |
| 5972 | Other eye disorders | Glaucoma | 97876 | 55921 | 9368 | 0.0609115 | 0.0022719 |
| 23347 | Melanomas of skin | Other skin disorders | 37939 | 145255 | 9363 | 0.0511098 | 0.0022707 |
| 5757 | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | 56967 | 64243 | 9320 | 0.0768913 | 0.0022603 |
| 11018 | Septicemia (except in labor) | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 144834 | 121004 | 9297 | 0.0349724 | 0.0022547 |
| 25220 | Other congenital anomalies | Digestive congenital anomalies | 114619 | 9122 | 9122 | 0.0737185 | 0.0022123 |
| 620 | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | Viral infection | 56967 | 224492 | 8970 | 0.0318697 | 0.0021754 |
| 16499 | Pancreatic disorders (not diabetes) | Other liver diseases | 56562 | 281545 | 8950 | 0.0264709 | 0.0021706 |
| 16633 | Other endocrine disorders | Pancreatic disorders (not diabetes) | 76089 | 56562 | 8759 | 0.0660304 | 0.0021242 |
| 1147 | Cancer of stomach | Cancer of esophagus | 97846 | 30389 | 8693 | 0.0677896 | 0.0021082 |
| 21466 | Viral infection | Other complications of pregnancy | 224492 | 208159 | 8399 | 0.0194129 | 0.0020369 |
| 5410 | Other nervous system disorders | Anxiety disorders | 127472 | 84284 | 8211 | 0.0387758 | 0.0019913 |
| 5860 | Other nervous system disorders | Multiple sclerosis | 127472 | 64331 | 8161 | 0.0425489 | 0.0019792 |
| 21577 | Other congenital anomalies | Other complications of pregnancy | 114619 | 208159 | 8114 | 0.0251380 | 0.0019678 |
| 21464 | HIV infection | Other complications of pregnancy | 120631 | 208159 | 8035 | 0.0244381 | 0.0019487 |
| 5342 | Anxiety disorders | Adjustment disorders | 84284 | 76856 | 7968 | 0.0494477 | 0.0019324 |
| 5946 | Glaucoma | Cataract | 55921 | 59259 | 7946 | 0.0689877 | 0.0019271 |
| 26674 | Paralysis | Spinal cord injury | 94889 | 54947 | 7916 | 0.0528311 | 0.0019198 |
| 3701 | Secondary malignancies | Cancer of bladder | 325699 | 67224 | 7756 | 0.0197392 | 0.0018810 |
| 3475 | Cancer of bladder | Cancer of prostate | 67224 | 111972 | 7739 | 0.0431873 | 0.0018769 |
| 76 | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | Tuberculosis | 64243 | 218021 | 7680 | 0.0272086 | 0.0018626 |
| 18739 | Cancer of prostate | Hyperplasia of prostate | 111972 | 16096 | 7653 | 0.0597573 | 0.0018560 |
| 6829 | Heart valve disorders | Pulmonary heart disease | 35137 | 57401 | 7560 | 0.0816962 | 0.0018335 |
| 20066 | Cancer of ovary | Ovarian cyst | 38879 | 15248 | 7369 | 0.1361428 | 0.0017871 |
| 7301 | Cardiac dysrhythmias | Conduction disorders | 148978 | 21704 | 7212 | 0.0422540 | 0.0017491 |
| 5580 | Other nervous system disorders | Mood disorders | 127472 | 138517 | 7203 | 0.0270801 | 0.0017469 |
| 11023 | Viral infection | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 224492 | 121004 | 7136 | 0.0206544 | 0.0017306 |
| 23368 | Secondary malignancies | Other skin disorders | 325699 | 145255 | 7094 | 0.0150630 | 0.0017204 |
| 20935 | Other complications of pregnancy | Spontaneous abortion | 208159 | 19545 | 6990 | 0.0306977 | 0.0016952 |
| 16541 | Other skin disorders | Other liver diseases | 145255 | 281545 | 6875 | 0.0161082 | 0.0016673 |
| 20464 | Other complications of pregnancy | Female infertility | 208159 | 48656 | 6856 | 0.0266963 | 0.0016627 |
| 4038 | Leukemias | Hodgkin`s disease | 267725 | 41418 | 6660 | 0.0215434 | 0.0016152 |
| 5949 | Other eye disorders | Cataract | 97876 | 59259 | 6579 | 0.0418685 | 0.0015955 |
| 4819 | Mood disorders | Disorders of lipid metabolism | 138517 | 154188 | 6473 | 0.0221144 | 0.0015698 |
| 3081 | Leukemias | Cancer of breast | 267725 | 299768 | 6456 | 0.0113764 | 0.0015657 |
| 6126 | Cardiac dysrhythmias | Acute myocardial infarction | 148978 | 75566 | 6380 | 0.0284131 | 0.0015473 |
| 14217 | Other gastrointestinal disorders | Esophageal disorders | 86745 | 30886 | 6320 | 0.0537273 | 0.0015327 |
| 306 | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | Septicemia (except in labor) | 64243 | 144834 | 6261 | 0.0299459 | 0.0015184 |
| 4165 | Viral infection | Leukemias | 224492 | 267725 | 6207 | 0.0126103 | 0.0015053 |
| 16409 | Septicemia (except in labor) | Other liver diseases | 144834 | 281545 | 6196 | 0.0145317 | 0.0015027 |
| 3960 | Other nervous system disorders | Cancer of brain and nervous system | 127472 | 17423 | 6157 | 0.0424928 | 0.0014932 |
| 1364 | Cancer of colon | Cancer of stomach | 88995 | 97846 | 6133 | 0.0328247 | 0.0014874 |
| 4168 | Multiple myeloma | Leukemias | 39523 | 267725 | 6035 | 0.0196421 | 0.0014636 |
| 5347 | Mood disorders | Adjustment disorders | 138517 | 76856 | 5970 | 0.0277194 | 0.0014478 |
| 1249 | Esophageal disorders | Cancer of esophagus | 30886 | 30389 | 5940 | 0.0969400 | 0.0014406 |
| 248 | Viral infection | Septicemia (except in labor) | 224492 | 144834 | 5916 | 0.0160184 | 0.0014348 |
| 23380 | Immunity disorders | Other skin disorders | 96804 | 145255 | 5777 | 0.0238661 | 0.0014010 |
| 1374 | Cancer of breast | Cancer of stomach | 299768 | 97846 | 5722 | 0.0143908 | 0.0013877 |
| 455 | HIV infection | Mycoses | 120631 | 106711 | 5718 | 0.0251515 | 0.0013867 |
| 26588 | Other fractures | Fracture of neck of femur (hip) | 186529 | 6386 | 5556 | 0.0288002 | 0.0013474 |
| 237 | Lymphadenitis | Tuberculosis | 13791 | 218021 | 5551 | 0.0239461 | 0.0013462 |
| 11111 | Influenza | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 82385 | 121004 | 5543 | 0.0272532 | 0.0013443 |
| 5388 | Substance-related disorders | Anxiety disorders | 89475 | 84284 | 5518 | 0.0317566 | 0.0013382 |
| 245 | Mycoses | Septicemia (except in labor) | 106711 | 144834 | 5510 | 0.0219046 | 0.0013363 |
| 6845 | Other circulatory disease | Pulmonary heart disease | 68286 | 57401 | 5470 | 0.0435208 | 0.0013266 |
| 23420 | Other nervous system disorders | Other skin disorders | 127472 | 145255 | 5439 | 0.0199430 | 0.0013191 |
| 13510 | Septicemia (except in labor) | Intestinal infection | 144834 | 49613 | 5407 | 0.0278071 | 0.0013113 |
| 21497 | Diabetes mellitus with complications | Other complications of pregnancy | 95877 | 208159 | 5269 | 0.0173302 | 0.0012778 |
| 20224 | Cancer of breast | Menopausal disorders | 299768 | 18447 | 5266 | 0.0165486 | 0.0012771 |
| 21090 | Other complications of pregnancy | Induced abortion | 208159 | 28314 | 5235 | 0.0221378 | 0.0012696 |
| 4645 | Disorders of lipid metabolism | Diabetes mellitus with complications | 154188 | 95877 | 5230 | 0.0209146 | 0.0012684 |
| 7662 | Syncope | Cardiac dysrhythmias | 16671 | 148978 | 5168 | 0.0311985 | 0.0012533 |
| 21556 | Normal pregnancy and/or delivery | Other complications of pregnancy | 12864 | 208159 | 5117 | 0.0231514 | 0.0012410 |
| 2151 | Secondary malignancies | Cancer of pancreas | 325699 | 39043 | 5081 | 0.0139304 | 0.0012322 |
| 3078 | Cancer of thyroid | Cancer of breast | 61207 | 299768 | 5077 | 0.0140647 | 0.0012313 |
| 16455 | Immunity disorders | Other liver diseases | 96804 | 281545 | 5022 | 0.0132735 | 0.0012179 |
| 11965 | Other upper respiratory disease | Other upper respiratory infections | 9212 | 12419 | 5014 | 0.2317970 | 0.0012160 |
| 618 | Sexually transmitted infections (not HIV or hepatitis) | Viral infection | 34644 | 224492 | 4978 | 0.0192100 | 0.0012073 |
| 19155 | Other female genital disorders | Other male genital disorders | 14107 | 7911 | 4973 | 0.2258607 | 0.0012061 |
| 16505 | Chronic kidney disease | Other liver diseases | 67359 | 281545 | 4931 | 0.0141328 | 0.0011959 |
| 7534 | Cardiac arrest and ventricular fibrillation | Cardiac dysrhythmias | 6736 | 148978 | 4848 | 0.0311340 | 0.0011757 |
| 6311 | Disorders of lipid metabolism | Coronary atherosclerosis and other heart disease | 154188 | 16305 | 4814 | 0.0282358 | 0.0011675 |
| 5588 | Alcohol-related disorders | Personality disorders | 44257 | 103317 | 4807 | 0.0325735 | 0.0011658 |
| 121 | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | Tuberculosis | 121004 | 218021 | 4795 | 0.0141435 | 0.0011629 |
| 16685 | Other gastrointestinal disorders | Pancreatic disorders (not diabetes) | 86745 | 56562 | 4770 | 0.0332852 | 0.0011568 |
| 6259 | Shock | Acute myocardial infarction | 193946 | 75566 | 4766 | 0.0176838 | 0.0011559 |
| 3981 | Other endocrine disorders | Cancer of thyroid | 76089 | 61207 | 4748 | 0.0345822 | 0.0011515 |
| 5558 | Substance-related disorders | Mood disorders | 89475 | 138517 | 4738 | 0.0207814 | 0.0011491 |
| 5515 | Other nervous system disorders | Developmental disorders | 127472 | 63628 | 4701 | 0.0245997 | 0.0011401 |
| 16469 | Mood disorders | Other liver diseases | 138517 | 281545 | 4700 | 0.0111888 | 0.0011398 |
| 17316 | Abdominal pain | Other gastrointestinal disorders | 73039 | 86745 | 4649 | 0.0290955 | 0.0011275 |
| 4742 | Other nervous system disorders | Other endocrine disorders | 127472 | 76089 | 4618 | 0.0226861 | 0.0011200 |
| 5798 | Other nervous system disorders | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | 127472 | 56967 | 4606 | 0.0249730 | 0.0011171 |
| 17267 | Other skin disorders | Other gastrointestinal disorders | 145255 | 86745 | 4597 | 0.0198147 | 0.0011149 |
| 1584 | Cancer of prostate | Cancer of colon | 111972 | 88995 | 4567 | 0.0227251 | 0.0011076 |
| 3069 | Cancer of ovary | Cancer of breast | 38879 | 299768 | 4500 | 0.0132882 | 0.0010913 |
| 9975 | Disorders of lipid metabolism | Other circulatory disease | 154188 | 68286 | 4500 | 0.0202271 | 0.0010913 |
| 4845 | Other nervous system disorders | Disorders of lipid metabolism | 127472 | 154188 | 4457 | 0.0158240 | 0.0010809 |
| 23416 | Other eye disorders | Other skin disorders | 97876 | 145255 | 4449 | 0.0182988 | 0.0010790 |
| 5490 | Personality disorders | Developmental disorders | 103317 | 63628 | 4438 | 0.0265836 | 0.0010763 |
| 943 | Cancer of thyroid | Cancer of head and neck | 61207 | 79442 | 4350 | 0.0309281 | 0.0010550 |
| 4805 | Immunity disorders | Disorders of lipid metabolism | 96804 | 154188 | 4340 | 0.0172914 | 0.0010525 |
| 10054 | Other liver diseases | Other circulatory disease | 281545 | 68286 | 4339 | 0.0124031 | 0.0010523 |
| 16528 | Other complications of pregnancy | Other liver diseases | 208159 | 281545 | 4272 | 0.0087236 | 0.0010360 |
| 7666 | Shock | Cardiac dysrhythmias | 193946 | 148978 | 4240 | 0.0123643 | 0.0010283 |
| 21396 | Other complications of pregnancy | Ectopic pregnancy | 208159 | 15016 | 4176 | 0.0187118 | 0.0010128 |
| 17853 | Septicemia (except in labor) | Urinary tract infections | 144834 | 50967 | 4155 | 0.0212205 | 0.0010077 |
| 11021 | HIV infection | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 120631 | 121004 | 4143 | 0.0171457 | 0.0010048 |
| 17225 | Other nervous system disorders | Other gastrointestinal disorders | 127472 | 86745 | 4075 | 0.0190228 | 0.0009883 |
| 1367 | Cancer of pancreas | Cancer of stomach | 39043 | 97846 | 4072 | 0.0297467 | 0.0009875 |
| 20932 | Induced abortion | Spontaneous abortion | 28314 | 19545 | 4046 | 0.0845400 | 0.0009812 |
| 16588 | Shock | Other liver diseases | 193946 | 281545 | 4020 | 0.0084544 | 0.0009749 |
| 21465 | Hepatitis | Other complications of pregnancy | 204207 | 208159 | 4016 | 0.0097389 | 0.0009740 |
| 638 | Other nervous system disorders | Viral infection | 127472 | 224492 | 3995 | 0.0113506 | 0.0009689 |
| 21461 | Septicemia (except in labor) | Other complications of pregnancy | 144834 | 208159 | 3965 | 0.0112325 | 0.0009616 |
| 4103 | Leukemias | Non-Hodgkin`s lymphoma | 267725 | 19130 | 3937 | 0.0137247 | 0.0009548 |
| 3090 | Other endocrine disorders | Cancer of breast | 76089 | 299768 | 3933 | 0.0104641 | 0.0009538 |
| 1471 | Other gastrointestinal disorders | Cancer of stomach | 86745 | 97846 | 3903 | 0.0211440 | 0.0009466 |
| 19652 | Female infertility | Endometriosis | 48656 | 21524 | 3897 | 0.0555286 | 0.0009451 |
| 5698 | Other nervous system disorders | Substance-related disorders | 127472 | 89475 | 3891 | 0.0179353 | 0.0009436 |
| 16495 | Other nervous system disorders | Other liver diseases | 127472 | 281545 | 3881 | 0.0094886 | 0.0009412 |
| 16440 | Leukemias | Other liver diseases | 267725 | 281545 | 3874 | 0.0070530 | 0.0009395 |
| 495 | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | Mycoses | 64243 | 106711 | 3866 | 0.0226143 | 0.0009376 |
| 17718 | Disorders of lipid metabolism | Chronic kidney disease | 154188 | 67359 | 3865 | 0.0174455 | 0.0009373 |
| 11116 | Asthma | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 149660 | 121004 | 3853 | 0.0142354 | 0.0009344 |
| 4162 | Mycoses | Leukemias | 106711 | 267725 | 3834 | 0.0102394 | 0.0009298 |
| 5489 | Mood disorders | Developmental disorders | 138517 | 63628 | 3830 | 0.0189468 | 0.0009289 |
| 16627 | Secondary malignancies | Pancreatic disorders (not diabetes) | 325699 | 56562 | 3814 | 0.0099775 | 0.0009250 |
| 28678 | Abdominal pain | Nausea and vomiting | 73039 | 32250 | 3793 | 0.0360247 | 0.0009199 |
| 1176 | Secondary malignancies | Cancer of esophagus | 325699 | 30389 | 3755 | 0.0105451 | 0.0009107 |
| 16590 | Abdominal pain | Other liver diseases | 73039 | 281545 | 3746 | 0.0105645 | 0.0009085 |
| 17173 | Secondary malignancies | Other gastrointestinal disorders | 325699 | 86745 | 3736 | 0.0090582 | 0.0009061 |
| 350 | Respiratory distress syndrome | Septicemia (except in labor) | 35066 | 144834 | 3717 | 0.0206615 | 0.0009014 |
| 3074 | Cancer of bladder | Cancer of breast | 67224 | 299768 | 3717 | 0.0101283 | 0.0009014 |
| 3257 | Secondary malignancies | Cancer of cervix | 325699 | 35740 | 3703 | 0.0102452 | 0.0008981 |
| 16425 | Cancer of breast | Other liver diseases | 299768 | 281545 | 3703 | 0.0063701 | 0.0008981 |
| 5841 | Other nervous system disorders | Parkinson`s disease | 127472 | 58740 | 3679 | 0.0197571 | 0.0008922 |
| 6001 | Other nervous system disorders | Other eye disorders | 127472 | 97876 | 3679 | 0.0163259 | 0.0008922 |
| 16449 | Other endocrine disorders | Other liver diseases | 76089 | 281545 | 3671 | 0.0102647 | 0.0008903 |
| 21550 | Prolonged pregnancy | Other complications of pregnancy | 11626 | 208159 | 3667 | 0.0166845 | 0.0008893 |
| 23376 | Disorders of lipid metabolism | Other skin disorders | 154188 | 145255 | 3665 | 0.0122394 | 0.0008888 |
| 12438 | Other skin disorders | Asthma | 145255 | 149660 | 3663 | 0.0124205 | 0.0008884 |
| 27985 | Shock | Burns | 193946 | 79311 | 3659 | 0.0133903 | 0.0008874 |
| 11088 | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 64243 | 121004 | 3601 | 0.0194389 | 0.0008733 |
| 931 | Cancer of breast | Cancer of head and neck | 299768 | 79442 | 3595 | 0.0094802 | 0.0008719 |
| 6877 | Other liver diseases | Pulmonary heart disease | 281545 | 57401 | 3577 | 0.0105533 | 0.0008675 |
| 23394 | Mood disorders | Other skin disorders | 138517 | 145255 | 3558 | 0.0125382 | 0.0008629 |
| 7531 | Heart valve disorders | Cardiac dysrhythmias | 35137 | 148978 | 3505 | 0.0190370 | 0.0008500 |
| 3334 | Secondary malignancies | Cancer of ovary | 325699 | 38879 | 3500 | 0.0096001 | 0.0008488 |
| 529 | Immunity disorders | HIV infection | 96804 | 120631 | 3498 | 0.0160876 | 0.0008483 |
| 4716 | Mood disorders | Other endocrine disorders | 138517 | 76089 | 3490 | 0.0162624 | 0.0008464 |
| 12488 | Allergic reactions | Asthma | 20593 | 149660 | 3486 | 0.0204754 | 0.0008454 |
| 25543 | Developmental disorders | Other congenital anomalies | 63628 | 114619 | 3478 | 0.0195122 | 0.0008435 |
| 6834 | Cardiac dysrhythmias | Pulmonary heart disease | 148978 | 57401 | 3475 | 0.0168380 | 0.0008428 |
| 13515 | Viral infection | Intestinal infection | 224492 | 49613 | 3448 | 0.0125791 | 0.0008362 |
| 4996 | Hepatitis | Immunity disorders | 204207 | 96804 | 3432 | 0.0114016 | 0.0008323 |
| 25457 | Other congenital anomalies | Nervous system congenital anomalies | 114619 | 3429 | 3429 | 0.0290475 | 0.0008316 |
| 26694 | Other fractures | Spinal cord injury | 186529 | 54947 | 3417 | 0.0141505 | 0.0008287 |
| 4041 | Secondary malignancies | Hodgkin`s disease | 325699 | 41418 | 3400 | 0.0092614 | 0.0008246 |
| 4698 | Disorders of lipid metabolism | Other endocrine disorders | 154188 | 76089 | 3386 | 0.0147040 | 0.0008212 |
| 247 | Hepatitis | Septicemia (except in labor) | 204207 | 144834 | 3379 | 0.0096808 | 0.0008195 |
| 192 | Other skin disorders | Tuberculosis | 145255 | 218021 | 3365 | 0.0092629 | 0.0008161 |
| 4357 | Thyroid disorders | Secondary malignancies | 46553 | 325699 | 3312 | 0.0088972 | 0.0008032 |
| 23853 | Other fractures | Osteoarthritis | 186529 | 60167 | 3251 | 0.0131782 | 0.0007884 |
| 24219 | Pathological fracture | Osteoporosis | 25288 | 66779 | 3243 | 0.0352243 | 0.0007865 |
| 23350 | Cancer of breast | Other skin disorders | 299768 | 145255 | 3235 | 0.0072693 | 0.0007846 |
| 1587 | Cancer of bladder | Cancer of colon | 67224 | 88995 | 3233 | 0.0206953 | 0.0007841 |
| 11145 | Urinary tract infections | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 50967 | 121004 | 3226 | 0.0187590 | 0.0007824 |
| 5775 | Other nervous system disorders | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | 127472 | 64243 | 3222 | 0.0168062 | 0.0007814 |
| 270 | Leukemias | Septicemia (except in labor) | 267725 | 144834 | 3221 | 0.0078074 | 0.0007812 |
| 369 | Burns | Septicemia (except in labor) | 79311 | 144834 | 3212 | 0.0143300 | 0.0007790 |
| 619 | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | Viral infection | 64243 | 224492 | 3212 | 0.0111244 | 0.0007790 |
| 16129 | Other liver diseases | Biliary tract disease | 281545 | 7246 | 3209 | 0.0111118 | 0.0007782 |
| 3067 | Cancer of uterus | Cancer of breast | 35011 | 299768 | 3204 | 0.0095705 | 0.0007770 |
| 11201 | Respiratory distress syndrome | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 35066 | 121004 | 3203 | 0.0205228 | 0.0007768 |
| 16412 | HIV infection | Other liver diseases | 120631 | 281545 | 3179 | 0.0079045 | 0.0007710 |
| 5013 | Mood disorders | Immunity disorders | 138517 | 96804 | 3165 | 0.0134497 | 0.0007676 |
| 4359 | Other endocrine disorders | Secondary malignancies | 76089 | 325699 | 3161 | 0.0078673 | 0.0007666 |
| 24610 | Other congenital anomalies | Other acquired deformities | 114619 | 22527 | 3111 | 0.0226839 | 0.0007545 |
| 5351 | Substance-related disorders | Adjustment disorders | 89475 | 76856 | 3096 | 0.0186135 | 0.0007508 |
| 3 | Mycoses | Tuberculosis | 106711 | 218021 | 3073 | 0.0094632 | 0.0007453 |
| 26059 | Shock | Respiratory distress syndrome | 193946 | 35066 | 3061 | 0.0133661 | 0.0007424 |
| 5557 | Alcohol-related disorders | Mood disorders | 44257 | 138517 | 3037 | 0.0166161 | 0.0007365 |
| 1467 | Other liver diseases | Cancer of stomach | 281545 | 97846 | 3036 | 0.0080023 | 0.0007363 |
| 23365 | Leukemias | Other skin disorders | 267725 | 145255 | 3025 | 0.0073248 | 0.0007336 |
| 20387 | Cancer of ovary | Female infertility | 38879 | 48656 | 3023 | 0.0345348 | 0.0007331 |
| 5387 | Alcohol-related disorders | Anxiety disorders | 44257 | 84284 | 3016 | 0.0234633 | 0.0007314 |
| 17715 | Diabetes mellitus with complications | Chronic kidney disease | 95877 | 67359 | 2988 | 0.0183048 | 0.0007247 |
| 16448 | Diabetes mellitus with complications | Other liver diseases | 95877 | 281545 | 2965 | 0.0078559 | 0.0007191 |
| 23341 | Mycoses | Other skin disorders | 106711 | 145255 | 2961 | 0.0117516 | 0.0007181 |
| 7297 | Other nervous system disorders | Conduction disorders | 127472 | 21704 | 2951 | 0.0197820 | 0.0007157 |
| 27005 | Other fractures | Fracture of lower limb | 186529 | 3667 | 2950 | 0.0155103 | 0.0007154 |
| 11227 | Shock | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 193946 | 121004 | 2918 | 0.0092650 | 0.0007077 |
| 1663 | Other liver diseases | Cancer of colon | 281545 | 88995 | 2900 | 0.0078264 | 0.0007033 |
| 5039 | Other nervous system disorders | Immunity disorders | 127472 | 96804 | 2897 | 0.0129171 | 0.0007026 |
| 16500 | Gastrointestinal hemorrhage | Other liver diseases | 42743 | 281545 | 2895 | 0.0089272 | 0.0007021 |
| 3160 | Cancer of ovary | Cancer of uterus | 38879 | 35011 | 2888 | 0.0390851 | 0.0007004 |
| 3340 | Other endocrine disorders | Cancer of ovary | 76089 | 38879 | 2886 | 0.0251026 | 0.0006999 |
| 23344 | Viral infection | Other skin disorders | 224492 | 145255 | 2883 | 0.0077972 | 0.0006992 |
| 16472 | Alcohol-related disorders | Other liver diseases | 44257 | 281545 | 2878 | 0.0088336 | 0.0006980 |
| 13616 | Other liver diseases | Intestinal infection | 281545 | 49613 | 2859 | 0.0086333 | 0.0006934 |
| 246 | HIV infection | Septicemia (except in labor) | 120631 | 144834 | 2857 | 0.0107622 | 0.0006929 |
| 547 | Substance-related disorders | HIV infection | 89475 | 120631 | 2856 | 0.0135931 | 0.0006926 |
| 13620 | Other gastrointestinal disorders | Intestinal infection | 86745 | 49613 | 2856 | 0.0209449 | 0.0006926 |
| 14213 | Other liver diseases | Esophageal disorders | 281545 | 30886 | 2818 | 0.0090196 | 0.0006834 |
| 4813 | Adjustment disorders | Disorders of lipid metabolism | 76856 | 154188 | 2786 | 0.0120583 | 0.0006757 |
| 148 | Other liver diseases | Tuberculosis | 281545 | 218021 | 2758 | 0.0055208 | 0.0006689 |
| 5 | Hepatitis | Tuberculosis | 204207 | 218021 | 2742 | 0.0064941 | 0.0006650 |
| 16287 | Alcohol-related disorders | Liver disease; alcohol-related | 44257 | 2733 | 2733 | 0.0581613 | 0.0006628 |
| 16314 | Other liver diseases | Liver disease; alcohol-related | 281545 | 2733 | 2733 | 0.0096138 | 0.0006628 |
| 17199 | Mood disorders | Other gastrointestinal disorders | 138517 | 86745 | 2730 | 0.0121192 | 0.0006621 |
| 5895 | Other nervous system disorders | Paralysis | 127472 | 94889 | 2719 | 0.0122279 | 0.0006594 |
| 55 | Immunity disorders | Tuberculosis | 96804 | 218021 | 2714 | 0.0086207 | 0.0006582 |
| 4182 | Immunity disorders | Leukemias | 96804 | 267725 | 2711 | 0.0074370 | 0.0006575 |
| 13197 | Other upper respiratory disease | Other lower respiratory disease | 9212 | 17462 | 2708 | 0.1015221 | 0.0006567 |
| 6 | Viral infection | Tuberculosis | 224492 | 218021 | 2696 | 0.0060925 | 0.0006538 |
| 3068 | Cancer of cervix | Cancer of breast | 35740 | 299768 | 2696 | 0.0080356 | 0.0006538 |
| 16635 | Disorders of lipid metabolism | Pancreatic disorders (not diabetes) | 154188 | 56562 | 2684 | 0.0127355 | 0.0006509 |
| 24145 | Cancer of breast | Osteoporosis | 299768 | 66779 | 2673 | 0.0072924 | 0.0006483 |
| 6937 | Other congenital anomalies | Pulmonary heart disease | 114619 | 57401 | 2657 | 0.0154459 | 0.0006444 |
| 15276 | Abdominal pain | Abdominal hernia | 73039 | 14062 | 2628 | 0.0301719 | 0.0006373 |
| 21492 | Secondary malignancies | Other complications of pregnancy | 325699 | 208159 | 2626 | 0.0049189 | 0.0006369 |
| 3175 | Secondary malignancies | Cancer of uterus | 325699 | 35011 | 2601 | 0.0072108 | 0.0006308 |
| 20324 | Osteoporosis | Menopausal disorders | 66779 | 18447 | 2601 | 0.0305189 | 0.0006308 |
| 5576 | Other eye disorders | Mood disorders | 97876 | 138517 | 2575 | 0.0108929 | 0.0006245 |
| 25567 | Other eye disorders | Other congenital anomalies | 97876 | 114619 | 2560 | 0.0120473 | 0.0006209 |
| 24476 | Other acquired deformities | Acquired foot deformities | 22527 | 2544 | 2544 | 0.1014718 | 0.0006170 |
| 11137 | Other liver diseases | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 281545 | 121004 | 2542 | 0.0063148 | 0.0006165 |
| 16418 | Cancer of pancreas | Other liver diseases | 39043 | 281545 | 2535 | 0.0079073 | 0.0006148 |
| 27090 | Paralysis | Other fractures | 94889 | 186529 | 2528 | 0.0089831 | 0.0006131 |
| 1572 | Cancer of pancreas | Cancer of colon | 39043 | 88995 | 2508 | 0.0195879 | 0.0006082 |
| 13708 | Abdominal pain | Intestinal infection | 73039 | 49613 | 2497 | 0.0203584 | 0.0006056 |
| 11871 | Viral infection | Other upper respiratory infections | 224492 | 12419 | 2491 | 0.0105145 | 0.0006041 |
| 27051 | Secondary malignancies | Other fractures | 325699 | 186529 | 2487 | 0.0048553 | 0.0006031 |
| 1594 | Leukemias | Cancer of colon | 267725 | 88995 | 2484 | 0.0069634 | 0.0006024 |
| 21522 | Substance-related disorders | Other complications of pregnancy | 89475 | 208159 | 2476 | 0.0083189 | 0.0006005 |
| 5611 | Other nervous system disorders | Personality disorders | 127472 | 103317 | 2466 | 0.0106851 | 0.0005981 |
| 21583 | Birth trauma | Other complications of pregnancy | 11058 | 208159 | 2457 | 0.0112081 | 0.0005959 |
| 17943 | Calculus of urinary tract | Urinary tract infections | 5393 | 50967 | 2454 | 0.0435415 | 0.0005951 |
| 23434 | Other connective tissue disease | Other skin disorders | 17076 | 145255 | 2450 | 0.0150926 | 0.0005942 |
| 28704 | Secondary malignancies | Abdominal pain | 325699 | 73039 | 2448 | 0.0061394 | 0.0005937 |
| 16632 | Diabetes mellitus with complications | Pancreatic disorders (not diabetes) | 95877 | 56562 | 2432 | 0.0159539 | 0.0005898 |
| 1667 | Other gastrointestinal disorders | Cancer of colon | 86745 | 88995 | 2421 | 0.0137760 | 0.0005871 |
| 5552 | Viral infection | Mood disorders | 224492 | 138517 | 2403 | 0.0066197 | 0.0005828 |
| 21609 | Abdominal pain | Other complications of pregnancy | 73039 | 208159 | 2396 | 0.0085207 | 0.0005811 |
| 5587 | Schizophrenia and other psychotic disorders | Personality disorders | 15858 | 103317 | 2392 | 0.0200713 | 0.0005801 |
| 3908 | Secondary malignancies | Cancer of brain and nervous system | 325699 | 17423 | 2389 | 0.0069625 | 0.0005794 |
| 1455 | Esophageal disorders | Cancer of stomach | 30886 | 97846 | 2348 | 0.0182394 | 0.0005694 |
| 5511 | Other eye disorders | Developmental disorders | 97876 | 63628 | 2346 | 0.0145260 | 0.0005690 |
| 4222 | Other nervous system disorders | Leukemias | 127472 | 267725 | 2345 | 0.0059337 | 0.0005687 |
| 5670 | Other nervous system disorders | Alcohol-related disorders | 127472 | 44257 | 2342 | 0.0136378 | 0.0005680 |
| 2133 | Cancer of breast | Cancer of pancreas | 299768 | 39043 | 2341 | 0.0069095 | 0.0005677 |
| 11052 | Leukemias | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 267725 | 121004 | 2326 | 0.0059836 | 0.0005641 |
| 11120 | Other lower respiratory disease | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 17462 | 121004 | 2326 | 0.0167983 | 0.0005641 |
| 285 | Immunity disorders | Septicemia (except in labor) | 96804 | 144834 | 2311 | 0.0095639 | 0.0005605 |
| 24728 | Other connective tissue disease | Systemic lupus erythematosus and connective tissue disorders | 17076 | 2479 | 2306 | 0.1179238 | 0.0005593 |
| 17730 | Adjustment disorders | Chronic kidney disease | 76856 | 67359 | 2300 | 0.0159484 | 0.0005578 |
| 3110 | Mood disorders | Cancer of breast | 138517 | 299768 | 2299 | 0.0052454 | 0.0005576 |
| 5382 | Developmental disorders | Anxiety disorders | 63628 | 84284 | 2275 | 0.0153808 | 0.0005517 |
| 5564 | Parkinson`s disease | Mood disorders | 58740 | 138517 | 2274 | 0.0115281 | 0.0005515 |
| 17964 | Other complications of pregnancy | Urinary tract infections | 208159 | 50967 | 2250 | 0.0086830 | 0.0005457 |
| 10144 | Shock | Other circulatory disease | 193946 | 68286 | 2246 | 0.0085649 | 0.0005447 |
| 5024 | Multiple sclerosis | Immunity disorders | 64331 | 96804 | 2242 | 0.0139138 | 0.0005437 |
| 4232 | Secondary malignancies | Multiple myeloma | 325699 | 39523 | 2238 | 0.0061278 | 0.0005428 |
| 17680 | Hepatitis | Chronic kidney disease | 204207 | 67359 | 2236 | 0.0082337 | 0.0005423 |
| 21607 | Shock | Other complications of pregnancy | 193946 | 208159 | 2236 | 0.0055607 | 0.0005423 |
| 16447 | Thyroid disorders | Other liver diseases | 46553 | 281545 | 2233 | 0.0068059 | 0.0005415 |
| 11281 | Immunity disorders | Influenza | 96804 | 82385 | 2218 | 0.0123780 | 0.0005379 |
| 17181 | Disorders of lipid metabolism | Other gastrointestinal disorders | 154188 | 86745 | 2216 | 0.0091976 | 0.0005374 |
| 1148 | Cancer of colon | Cancer of esophagus | 88995 | 30389 | 2208 | 0.0184949 | 0.0005355 |
| 16411 | Mycoses | Other liver diseases | 106711 | 281545 | 2202 | 0.0056715 | 0.0005340 |
| 281 | Disorders of lipid metabolism | Septicemia (except in labor) | 154188 | 144834 | 2192 | 0.0073306 | 0.0005316 |
| 3177 | Benign neoplasm of uterus | Cancer of uterus | 2194 | 35011 | 2183 | 0.0586749 | 0.0005294 |
| 28547 | Disorders of lipid metabolism | Shock | 154188 | 193946 | 2167 | 0.0062246 | 0.0005255 |
| 6856 | Asthma | Pulmonary heart disease | 149660 | 57401 | 2165 | 0.0104559 | 0.0005251 |
| 4405 | Other nervous system disorders | Secondary malignancies | 127472 | 325699 | 2163 | 0.0047730 | 0.0005246 |
| 16417 | Cancer of liver and intrahepatic bile duct | Other liver diseases | 5618 | 281545 | 2149 | 0.0074836 | 0.0005212 |
| 26687 | Other nervous system disorders | Spinal cord injury | 127472 | 54947 | 2141 | 0.0117367 | 0.0005192 |
| 12378 | Other lower respiratory disease | Asthma | 17462 | 149660 | 2137 | 0.0127871 | 0.0005183 |
| 10097 | Other skin disorders | Other circulatory disease | 145255 | 68286 | 2135 | 0.0099981 | 0.0005178 |
| 4841 | Other eye disorders | Disorders of lipid metabolism | 97876 | 154188 | 2131 | 0.0084542 | 0.0005168 |
| 10019 | Other nervous system disorders | Other circulatory disease | 127472 | 68286 | 2130 | 0.0108808 | 0.0005166 |
| 6137 | Other circulatory disease | Acute myocardial infarction | 68286 | 75566 | 2126 | 0.0147791 | 0.0005156 |
| 5911 | Other nervous system disorders | Epilepsy; convulsions | 127472 | 74226 | 2115 | 0.0104860 | 0.0005129 |
| 5345 | Developmental disorders | Adjustment disorders | 63628 | 76856 | 2111 | 0.0150266 | 0.0005120 |
| 4702 | Immunity disorders | Other endocrine disorders | 96804 | 76089 | 2097 | 0.0121289 | 0.0005086 |
| 3558 | Secondary malignancies | Cancer of testis | 325699 | 16094 | 2094 | 0.0061265 | 0.0005078 |
| 14146 | Secondary malignancies | Esophageal disorders | 325699 | 30886 | 2093 | 0.0058696 | 0.0005076 |
| 5783 | Multiple sclerosis | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | 64331 | 56967 | 2091 | 0.0172385 | 0.0005071 |
| 21477 | Cancer of ovary | Other complications of pregnancy | 38879 | 208159 | 2089 | 0.0084562 | 0.0005066 |
| 28622 | Secondary malignancies | Nausea and vomiting | 325699 | 32250 | 2075 | 0.0057969 | 0.0005032 |
| 1087 | Other skin disorders | Cancer of head and neck | 145255 | 79442 | 2072 | 0.0092213 | 0.0005025 |
| 23374 | Other endocrine disorders | Other skin disorders | 76089 | 145255 | 2067 | 0.0093384 | 0.0005013 |
| 17185 | Immunity disorders | Other gastrointestinal disorders | 96804 | 86745 | 2065 | 0.0112504 | 0.0005008 |
| 21474 | Cancer of breast | Other complications of pregnancy | 299768 | 208159 | 2062 | 0.0040596 | 0.0005001 |
| 329 | Other skin disorders | Septicemia (except in labor) | 145255 | 144834 | 2059 | 0.0070978 | 0.0004994 |
| 16773 | Abdominal pain | Pancreatic disorders (not diabetes) | 73039 | 56562 | 2058 | 0.0158795 | 0.0004991 |
| 575 | Sexually transmitted infections (not HIV or hepatitis) | Hepatitis | 34644 | 204207 | 2051 | 0.0085869 | 0.0004974 |
| 4643 | Other endocrine disorders | Diabetes mellitus with complications | 76089 | 95877 | 2051 | 0.0119268 | 0.0004974 |
| 457 | Viral infection | Mycoses | 224492 | 106711 | 2049 | 0.0061865 | 0.0004969 |
| 20460 | Spontaneous abortion | Female infertility | 19545 | 48656 | 2036 | 0.0298529 | 0.0004938 |
| 3482 | Leukemias | Cancer of prostate | 267725 | 111972 | 2029 | 0.0053437 | 0.0004921 |
| 5828 | Paralysis | Parkinson`s disease | 94889 | 58740 | 2025 | 0.0131811 | 0.0004911 |
| 11113 | Acute bronchitis | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 6384 | 121004 | 2022 | 0.0158728 | 0.0004904 |
| 28519 | Viral infection | Shock | 224492 | 193946 | 2019 | 0.0048251 | 0.0004896 |
| 8234 | Other circulatory disease | Acute cerebrovascular disease | 68286 | 6957 | 2016 | 0.0267932 | 0.0004889 |
| 1382 | Cancer of bladder | Cancer of stomach | 67224 | 97846 | 2012 | 0.0121888 | 0.0004880 |
| 12289 | Viral infection | Asthma | 224492 | 149660 | 2011 | 0.0053748 | 0.0004877 |
| 5350 | Alcohol-related disorders | Adjustment disorders | 44257 | 76856 | 2006 | 0.0165630 | 0.0004865 |
| 12333 | Immunity disorders | Asthma | 96804 | 149660 | 2003 | 0.0081269 | 0.0004858 |
| 21581 | Respiratory distress syndrome | Other complications of pregnancy | 35066 | 208159 | 1993 | 0.0081941 | 0.0004833 |
| 21498 | Other endocrine disorders | Other complications of pregnancy | 76089 | 208159 | 1992 | 0.0070080 | 0.0004831 |
| 1469 | Gastrointestinal hemorrhage | Cancer of stomach | 42743 | 97846 | 1986 | 0.0141263 | 0.0004816 |
| 4379 | Mood disorders | Secondary malignancies | 138517 | 325699 | 1981 | 0.0042674 | 0.0004804 |
| 16438 | Hodgkin`s disease | Other liver diseases | 41418 | 281545 | 1978 | 0.0061245 | 0.0004797 |
| 591 | Substance-related disorders | Hepatitis | 89475 | 204207 | 1966 | 0.0066943 | 0.0004768 |
| 19925 | Other endocrine disorders | Menstrual disorders | 76089 | 12598 | 1960 | 0.0221002 | 0.0004753 |
| 23288 | Other skin disorders | Chronic ulcer of skin | 145255 | 3216 | 1959 | 0.0131945 | 0.0004751 |
| 17736 | Mood disorders | Chronic kidney disease | 138517 | 67359 | 1950 | 0.0094717 | 0.0004729 |
| 21518 | Mood disorders | Other complications of pregnancy | 138517 | 208159 | 1949 | 0.0056220 | 0.0004727 |
| 17179 | Other endocrine disorders | Other gastrointestinal disorders | 76089 | 86745 | 1946 | 0.0119508 | 0.0004719 |
| 11067 | Immunity disorders | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 96804 | 121004 | 1944 | 0.0089253 | 0.0004715 |
| 4714 | Developmental disorders | Other endocrine disorders | 63628 | 76089 | 1940 | 0.0138852 | 0.0004705 |
| 3239 | Viral infection | Cancer of cervix | 224492 | 35740 | 1936 | 0.0074395 | 0.0004695 |
| 12332 | Cystic fibrosis | Asthma | 41834 | 149660 | 1921 | 0.0100316 | 0.0004659 |
| 13513 | HIV infection | Intestinal infection | 120631 | 49613 | 1921 | 0.0112838 | 0.0004659 |
| 13110 | Viral infection | Other lower respiratory disease | 224492 | 17462 | 1919 | 0.0079313 | 0.0004654 |
| 569 | Other nervous system disorders | HIV infection | 127472 | 120631 | 1914 | 0.0077145 | 0.0004642 |
| 23463 | Burns | Other skin disorders | 79311 | 145255 | 1914 | 0.0085231 | 0.0004642 |
| 20250 | Disorders of lipid metabolism | Menopausal disorders | 154188 | 18447 | 1905 | 0.0110348 | 0.0004620 |
| 4798 | Hepatitis | Disorders of lipid metabolism | 204207 | 154188 | 1898 | 0.0052958 | 0.0004603 |
| 16638 | Cystic fibrosis | Pancreatic disorders (not diabetes) | 41834 | 56562 | 1891 | 0.0192183 | 0.0004586 |
| 6850 | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | Pulmonary heart disease | 121004 | 57401 | 1881 | 0.0105434 | 0.0004562 |
| 11236 | Hepatitis | Influenza | 204207 | 82385 | 1863 | 0.0065005 | 0.0004518 |
| 20536 | Sexually transmitted infections (not HIV or hepatitis) | Other female genital disorders | 34644 | 14107 | 1857 | 0.0380915 | 0.0004504 |
| 20248 | Other endocrine disorders | Menopausal disorders | 76089 | 18447 | 1855 | 0.0196222 | 0.0004499 |
| 25572 | Heart valve disorders | Other congenital anomalies | 35137 | 114619 | 1852 | 0.0123668 | 0.0004491 |
| 21506 | Deficiency and other anemia | Other complications of pregnancy | 29917 | 208159 | 1836 | 0.0077118 | 0.0004453 |
| 2291 | Cancer of breast | Melanomas of skin | 299768 | 37939 | 1831 | 0.0054219 | 0.0004441 |
| 4631 | Other eye disorders | Thyroid disorders | 97876 | 46553 | 1830 | 0.0126706 | 0.0004438 |
| 27122 | Shock | Other fractures | 193946 | 186529 | 1828 | 0.0048045 | 0.0004433 |
| 7530 | Other nervous system disorders | Cardiac dysrhythmias | 127472 | 148978 | 1824 | 0.0065979 | 0.0004424 |
| 1379 | Cancer of prostate | Cancer of stomach | 111972 | 97846 | 1823 | 0.0086885 | 0.0004421 |
| 9993 | Mood disorders | Other circulatory disease | 138517 | 68286 | 1823 | 0.0088152 | 0.0004421 |
| 13706 | Shock | Intestinal infection | 193946 | 49613 | 1818 | 0.0074643 | 0.0004409 |
| 5891 | Other eye disorders | Paralysis | 97876 | 94889 | 1809 | 0.0093845 | 0.0004387 |
| 14215 | Gastrointestinal hemorrhage | Esophageal disorders | 42743 | 30886 | 1809 | 0.0245691 | 0.0004387 |
| 1389 | Leukemias | Cancer of stomach | 267725 | 97846 | 1805 | 0.0049375 | 0.0004378 |
| 10020 | Heart valve disorders | Other circulatory disease | 35137 | 68286 | 1795 | 0.0173559 | 0.0004353 |
| 23342 | HIV infection | Other skin disorders | 120631 | 145255 | 1788 | 0.0067247 | 0.0004336 |
| 4164 | Hepatitis | Leukemias | 204207 | 267725 | 1775 | 0.0037611 | 0.0004305 |
| 21475 | Cancer of uterus | Other complications of pregnancy | 35011 | 208159 | 1757 | 0.0072254 | 0.0004261 |
| 20138 | Female infertility | Ovarian cyst | 48656 | 15248 | 1754 | 0.0274474 | 0.0004254 |
| 12347 | Mood disorders | Asthma | 138517 | 149660 | 1751 | 0.0060761 | 0.0004247 |
| 17139 | Septicemia (except in labor) | Other gastrointestinal disorders | 144834 | 86745 | 1751 | 0.0075611 | 0.0004247 |
| 4350 | Hepatitis | Secondary malignancies | 204207 | 325699 | 1740 | 0.0032836 | 0.0004220 |
| 28596 | Abdominal pain | Shock | 73039 | 193946 | 1739 | 0.0065135 | 0.0004217 |
| 23363 | Hodgkin`s disease | Other skin disorders | 41418 | 145255 | 1738 | 0.0093104 | 0.0004215 |
| 7544 | Other circulatory disease | Cardiac dysrhythmias | 68286 | 148978 | 1736 | 0.0079903 | 0.0004210 |
| 5556 | Schizophrenia and other psychotic disorders | Mood disorders | 15858 | 138517 | 1730 | 0.0112065 | 0.0004196 |
| 20145 | Other complications of pregnancy | Ovarian cyst | 208159 | 15248 | 1728 | 0.0077348 | 0.0004191 |
| 16955 | Abdominal pain | Gastrointestinal hemorrhage | 73039 | 42743 | 1724 | 0.0148901 | 0.0004181 |
| 551 | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | HIV infection | 56967 | 120631 | 1717 | 0.0096679 | 0.0004164 |
| 21468 | Sexually transmitted infections (not HIV or hepatitis) | Other complications of pregnancy | 34644 | 208159 | 1715 | 0.0070633 | 0.0004159 |
| 21516 | Developmental disorders | Other complications of pregnancy | 63628 | 208159 | 1715 | 0.0063101 | 0.0004159 |
| 24292 | Secondary malignancies | Pathological fracture | 325699 | 25288 | 1692 | 0.0048207 | 0.0004103 |
| 550 | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | HIV infection | 64243 | 120631 | 1681 | 0.0090927 | 0.0004077 |
| 7606 | Other complications of pregnancy | Cardiac dysrhythmias | 208159 | 148978 | 1677 | 0.0046957 | 0.0004067 |
| 27108 | Intracranial injury | Other fractures | 18732 | 186529 | 1673 | 0.0081506 | 0.0004057 |
| 1582 | Cancer of ovary | Cancer of colon | 38879 | 88995 | 1670 | 0.0130597 | 0.0004050 |
| 4822 | Alcohol-related disorders | Disorders of lipid metabolism | 44257 | 154188 | 1666 | 0.0083953 | 0.0004040 |
| 3079 | Hodgkin`s disease | Cancer of breast | 41418 | 299768 | 1663 | 0.0048742 | 0.0004033 |
| 6073 | Disorders of lipid metabolism | Acute myocardial infarction | 154188 | 75566 | 1661 | 0.0072295 | 0.0004028 |
| 3247 | Cancer of bladder | Cancer of cervix | 67224 | 35740 | 1656 | 0.0160833 | 0.0004016 |
| 6123 | Pulmonary heart disease | Acute myocardial infarction | 57401 | 75566 | 1653 | 0.0124317 | 0.0004009 |
| 6784 | Disorders of lipid metabolism | Pulmonary heart disease | 154188 | 57401 | 1653 | 0.0078123 | 0.0004009 |
| 179 | Other complications of pregnancy | Tuberculosis | 208159 | 218021 | 1651 | 0.0038739 | 0.0004004 |
| 4106 | Secondary malignancies | Non-Hodgkin`s lymphoma | 325699 | 19130 | 1639 | 0.0047531 | 0.0003975 |
| 4408 | Hypertension with complications and secondary hypertension | Secondary malignancies | 8747 | 325699 | 1633 | 0.0048827 | 0.0003960 |
| 20463 | Ectopic pregnancy | Female infertility | 15016 | 48656 | 1632 | 0.0256314 | 0.0003958 |
| 11167 | Other complications of pregnancy | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 208159 | 121004 | 1629 | 0.0049489 | 0.0003951 |
| 474 | Immunity disorders | Mycoses | 96804 | 106711 | 1620 | 0.0079601 | 0.0003929 |
| 925 | Melanomas of skin | Cancer of head and neck | 37939 | 79442 | 1618 | 0.0137842 | 0.0003924 |
| 3082 | Multiple myeloma | Cancer of breast | 39523 | 299768 | 1618 | 0.0047688 | 0.0003924 |
| 27033 | Cancer of breast | Other fractures | 299768 | 186529 | 1616 | 0.0033231 | 0.0003919 |
| 21544 | Other nervous system disorders | Other complications of pregnancy | 127472 | 208159 | 1612 | 0.0048029 | 0.0003909 |
| 20622 | Other complications of pregnancy | Other female genital disorders | 208159 | 14107 | 1610 | 0.0072436 | 0.0003905 |
| 23440 | Other congenital anomalies | Other skin disorders | 114619 | 145255 | 1606 | 0.0061799 | 0.0003895 |
| 543 | Mood disorders | HIV infection | 138517 | 120631 | 1604 | 0.0061895 | 0.0003890 |
| 19659 | Other complications of pregnancy | Endometriosis | 208159 | 21524 | 1604 | 0.0069835 | 0.0003890 |
| 23372 | Thyroid disorders | Other skin disorders | 46553 | 145255 | 1597 | 0.0083260 | 0.0003873 |
| 1468 | Pancreatic disorders (not diabetes) | Cancer of stomach | 56562 | 97846 | 1596 | 0.0103363 | 0.0003871 |
| 17315 | Nausea and vomiting | Other gastrointestinal disorders | 32250 | 86745 | 1593 | 0.0133871 | 0.0003863 |
| 5786 | Epilepsy; convulsions | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | 74226 | 56967 | 1582 | 0.0120586 | 0.0003837 |
| 3148 | Nausea and vomiting | Cancer of breast | 32250 | 299768 | 1577 | 0.0047497 | 0.0003825 |
| 12329 | Disorders of lipid metabolism | Asthma | 154188 | 149660 | 1573 | 0.0051769 | 0.0003815 |
| 4609 | Mood disorders | Thyroid disorders | 138517 | 46553 | 1569 | 0.0084779 | 0.0003805 |
| 16130 | Pancreatic disorders (not diabetes) | Biliary tract disease | 56562 | 7246 | 1568 | 0.0245737 | 0.0003803 |
| 7636 | Other congenital anomalies | Cardiac dysrhythmias | 114619 | 148978 | 1567 | 0.0059447 | 0.0003800 |
| 590 | Alcohol-related disorders | Hepatitis | 44257 | 204207 | 1565 | 0.0062987 | 0.0003795 |
| 19650 | Ovarian cyst | Endometriosis | 15248 | 21524 | 1560 | 0.0424236 | 0.0003783 |
| 26635 | Secondary malignancies | Spinal cord injury | 325699 | 54947 | 1559 | 0.0040957 | 0.0003781 |
| 587 | Mood disorders | Hepatitis | 138517 | 204207 | 1553 | 0.0045313 | 0.0003766 |
| 3104 | Adjustment disorders | Cancer of breast | 76856 | 299768 | 1550 | 0.0041155 | 0.0003759 |
| 28536 | Leukemias | Shock | 267725 | 193946 | 1547 | 0.0033509 | 0.0003752 |
| 127 | Asthma | Tuberculosis | 149660 | 218021 | 1546 | 0.0042047 | 0.0003749 |
| 13558 | Immunity disorders | Intestinal infection | 96804 | 49613 | 1535 | 0.0104838 | 0.0003723 |
| 11114 | Other upper respiratory infections | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 12419 | 121004 | 1529 | 0.0114598 | 0.0003708 |
| 28551 | Immunity disorders | Shock | 96804 | 193946 | 1529 | 0.0052588 | 0.0003708 |
| 21496 | Thyroid disorders | Other complications of pregnancy | 46553 | 208159 | 1527 | 0.0059950 | 0.0003703 |
| 23828 | Osteoporosis | Osteoarthritis | 66779 | 60167 | 1527 | 0.0120287 | 0.0003703 |
| 3088 | Thyroid disorders | Cancer of breast | 46553 | 299768 | 1520 | 0.0043890 | 0.0003686 |
| 25453 | Other nervous system disorders | Nervous system congenital anomalies | 127472 | 3429 | 1518 | 0.0115966 | 0.0003681 |
| 25571 | Other nervous system disorders | Other congenital anomalies | 127472 | 114619 | 1518 | 0.0062704 | 0.0003681 |
| 17143 | Hepatitis | Other gastrointestinal disorders | 204207 | 86745 | 1516 | 0.0052105 | 0.0003677 |
| 4392 | Paralysis | Secondary malignancies | 94889 | 325699 | 1509 | 0.0035878 | 0.0003660 |
| 16558 | Other congenital anomalies | Other liver diseases | 114619 | 281545 | 1508 | 0.0038065 | 0.0003657 |
| 13624 | Urinary tract infections | Intestinal infection | 50967 | 49613 | 1502 | 0.0149334 | 0.0003643 |
| 26903 | Other fractures | Fracture of upper limb | 186529 | 1860 | 1501 | 0.0079676 | 0.0003640 |
| 20408 | Other endocrine disorders | Female infertility | 76089 | 48656 | 1499 | 0.0120165 | 0.0003635 |
| 23392 | Developmental disorders | Other skin disorders | 63628 | 145255 | 1499 | 0.0071763 | 0.0003635 |
| 19976 | Menopausal disorders | Menstrual disorders | 18447 | 12598 | 1498 | 0.0482525 | 0.0003633 |
| 11180 | Other skin disorders | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 145255 | 121004 | 1496 | 0.0056186 | 0.0003628 |
| 4817 | Developmental disorders | Disorders of lipid metabolism | 63628 | 154188 | 1495 | 0.0068636 | 0.0003626 |
| 21598 | Complications of surgical procedures or medical care | Other complications of pregnancy | 22087 | 208159 | 1493 | 0.0064844 | 0.0003621 |
| 23343 | Hepatitis | Other skin disorders | 204207 | 145255 | 1491 | 0.0042666 | 0.0003616 |
| 10061 | Chronic kidney disease | Other circulatory disease | 67359 | 68286 | 1490 | 0.0109846 | 0.0003614 |
| 25100 | Other congenital anomalies | Cardiac and circulatory congenital anomalies | 114619 | 1490 | 1490 | 0.0128328 | 0.0003614 |
| 20965 | Other congenital anomalies | Spontaneous abortion | 114619 | 19545 | 1489 | 0.0110984 | 0.0003611 |
| 3693 | Cancer of other urinary organs | Cancer of bladder | 3000 | 67224 | 1479 | 0.0210612 | 0.0003587 |
| 11022 | Hepatitis | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 204207 | 121004 | 1473 | 0.0045294 | 0.0003572 |
| 16467 | Developmental disorders | Other liver diseases | 63628 | 281545 | 1473 | 0.0042674 | 0.0003572 |
| 17155 | Cancer of breast | Other gastrointestinal disorders | 299768 | 86745 | 1472 | 0.0038084 | 0.0003570 |
| 16639 | Immunity disorders | Pancreatic disorders (not diabetes) | 96804 | 56562 | 1465 | 0.0095523 | 0.0003553 |
| 1158 | Cancer of breast | Cancer of esophagus | 299768 | 30389 | 1462 | 0.0044282 | 0.0003546 |
| 6070 | Diabetes mellitus with complications | Acute myocardial infarction | 95877 | 75566 | 1459 | 0.0085101 | 0.0003538 |
| 3972 | Leukemias | Cancer of thyroid | 267725 | 61207 | 1449 | 0.0044052 | 0.0003514 |
| 2138 | Cancer of prostate | Cancer of pancreas | 111972 | 39043 | 1448 | 0.0095885 | 0.0003512 |
| 5035 | Other eye disorders | Immunity disorders | 97876 | 96804 | 1437 | 0.0073813 | 0.0003485 |
| 24238 | Fracture of neck of femur (hip) | Osteoporosis | 6386 | 66779 | 1435 | 0.0196132 | 0.0003480 |
| 19575 | Cancer of uterus | Endometriosis | 35011 | 21524 | 1429 | 0.0252764 | 0.0003466 |
| 20534 | Viral infection | Other female genital disorders | 224492 | 14107 | 1429 | 0.0059891 | 0.0003466 |
| 5785 | Paralysis | Encephalitis (except that caused by tuberculosis or sexually transmitted disease) | 94889 | 56967 | 1424 | 0.0093773 | 0.0003453 |
| 4663 | Mood disorders | Diabetes mellitus with complications | 138517 | 95877 | 1422 | 0.0060667 | 0.0003449 |
| 16609 | Cancer of breast | Pancreatic disorders (not diabetes) | 299768 | 56562 | 1417 | 0.0039767 | 0.0003437 |
| 4711 | Anxiety disorders | Other endocrine disorders | 84284 | 76089 | 1414 | 0.0088169 | 0.0003429 |
| 16491 | Other eye disorders | Other liver diseases | 97876 | 281545 | 1414 | 0.0037267 | 0.0003429 |
| 20268 | Mood disorders | Menopausal disorders | 138517 | 18447 | 1408 | 0.0089702 | 0.0003415 |
| 5373 | Other nervous system disorders | Adjustment disorders | 127472 | 76856 | 1406 | 0.0068811 | 0.0003410 |
| 17801 | Other skin disorders | Chronic kidney disease | 145255 | 67359 | 1403 | 0.0065988 | 0.0003403 |
| 2280 | Abdominal pain | Cancer of pancreas | 73039 | 39043 | 1401 | 0.0124998 | 0.0003398 |
| 4685 | Other eye disorders | Diabetes mellitus with complications | 97876 | 95877 | 1398 | 0.0072154 | 0.0003390 |
| 17144 | Viral infection | Other gastrointestinal disorders | 224492 | 86745 | 1394 | 0.0044789 | 0.0003381 |
| 4053 | Immunity disorders | Hodgkin`s disease | 96804 | 41418 | 1393 | 0.0100780 | 0.0003378 |
| 5456 | Personality disorders | Delirium, dementia, and amnestic and other cognitive disorders | 103317 | 8506 | 1390 | 0.0124304 | 0.0003371 |
| 5762 | Paralysis | Meningitis (except that caused by tuberculosis or sexually transmitted disease) | 94889 | 64243 | 1384 | 0.0086972 | 0.0003356 |
| 634 | Other eye disorders | Viral infection | 97876 | 224492 | 1383 | 0.0042901 | 0.0003354 |
| 4196 | Mood disorders | Leukemias | 138517 | 267725 | 1381 | 0.0033995 | 0.0003349 |
| 4657 | Adjustment disorders | Diabetes mellitus with complications | 76856 | 95877 | 1374 | 0.0079545 | 0.0003332 |
| 4591 | Disorders of lipid metabolism | Thyroid disorders | 154188 | 46553 | 1372 | 0.0068347 | 0.0003327 |
| 16454 | Cystic fibrosis | Other liver diseases | 41834 | 281545 | 1372 | 0.0042427 | 0.0003327 |
| 378 | Abdominal pain | Septicemia (except in labor) | 73039 | 144834 | 1368 | 0.0062789 | 0.0003318 |
| 5990 | Other eye disorders | Inflammation; infection of eye (except that caused by tuberculosis or sexually transmitteddisease) | 97876 | 3963 | 1368 | 0.0134330 | 0.0003318 |
| 1755 | Abdominal pain | Cancer of colon | 73039 | 88995 | 1363 | 0.0084118 | 0.0003306 |
| 43 | Secondary malignancies | Tuberculosis | 325699 | 218021 | 1362 | 0.0025050 | 0.0003303 |
| 4401 | Other eye disorders | Secondary malignancies | 97876 | 325699 | 1359 | 0.0032084 | 0.0003296 |
| 6967 | Shock | Pulmonary heart disease | 193946 | 57401 | 1359 | 0.0054069 | 0.0003296 |
| 1386 | Cancer of thyroid | Cancer of stomach | 61207 | 97846 | 1357 | 0.0085317 | 0.0003291 |
| 152 | Other gastrointestinal disorders | Tuberculosis | 86745 | 218021 | 1356 | 0.0044493 | 0.0003289 |
| 936 | Cancer of prostate | Cancer of head and neck | 111972 | 79442 | 1353 | 0.0070684 | 0.0003281 |
| 5565 | Multiple sclerosis | Mood disorders | 64331 | 138517 | 1352 | 0.0066651 | 0.0003279 |