Demographics

Characteristic N = 7841
Sex
Male 407 (52%)
Female 377 (48%)
Age 38 (30, 48)
Education
más de 5to grado 582 (74%)
desconocido 187 (24%)
menos de 5to grado 15 (1.9%)

1 n (%); Median (IQR)

Symptoms by frequency.

Characteristic N = 7841
anosmia/ageusia 519 (66%)
ACV 13 (1.7%)
Sindrom_meningeo 556 (71%)
Encefalopatia 25 (3.2%)
Perifericos 72 (9.2%)
Sind_doloroso 430 (55%)
Empeoramiento_previo 16 (2.0%)
Trast_sueño 25 (3.2%)
neurocovid_severity
mild 493 (63%)
moderate 257 (33%)
severe 34 (4.3%)

1 n (%)

Symptoms by severity.

Characteristic mild, N = 4931 moderate, N = 2571 severe, N = 341 p-value2
anosmia/ageusia 309 (63%) 191 (74%) 19 (56%) 0.003
ACV 3 (0.6%) 7 (2.7%) 3 (8.8%) 0.002
Sindrom_meningeo 336 (68%) 197 (77%) 23 (68%) 0.047
Encefalopatia 11 (2.2%) 9 (3.5%) 5 (15%) 0.003
Perifericos 27 (5.5%) 39 (15%) 6 (18%) <0.001
Sind_doloroso 255 (52%) 160 (62%) 15 (44%) 0.010
Empeoramiento_previo 13 (2.6%) 2 (0.8%) 1 (2.9%) 0.13
Trast_sueño 9 (1.8%) 12 (4.7%) 4 (12%) 0.003
Comorbility 169 (34%) 59 (23%) 14 (41%) 0.003

1 n (%)

2 Pearson's Chi-squared test; Fisher's exact test

Comorbilities frequency

Characteristic N = 7841
Comorbility 242 (31%)
Overweigth/Obesity 48 (6.1%)
HTA 93 (12%)
Asma 9 (1.1%)
Thyroid_disorders 9 (1.1%)
Dyslipemia 23 (2.9%)
Autoinmune_disorders/Inmunesupresion 9 (1.1%)
Diabetes 29 (3.7%)
Pregnancy 7 (0.9%)
CVD 22 (2.8%)
TBQ-EPOC 63 (8.0%)
TVP-TEP 3 (0.4%)
Cancer 7 (0.9%)
HIV 7 (0.9%)
Trombofilia 2 (0.3%)
Atrial_fibrillation 3 (0.4%)
Renal_insufficiency 4 (0.5%)

1 n (%)

comorbility by severity

Characteristic mild, N = 4931 moderate, N = 2571 severe, N = 341 p-value2
Comorbility 169 (34%) 59 (23%) 14 (41%) 0.003
Overweigth/Obesity 42 (8.5%) 5 (1.9%) 1 (2.9%) <0.001
HTA 60 (12%) 29 (11%) 4 (12%) >0.9
Asma 5 (1.0%) 3 (1.2%) 1 (2.9%) 0.5
Thyroid_disorders 7 (1.4%) 1 (0.4%) 1 (2.9%) 0.2
Dyslipemia 20 (4.1%) 3 (1.2%) 0 (0%) 0.062
Autoinmune_disorders/Inmunesupresion 6 (1.2%) 2 (0.8%) 1 (2.9%) 0.4
Diabetes 23 (4.7%) 4 (1.6%) 2 (5.9%) 0.043
Pregnancy 7 (1.4%) 0 (0%) 0 (0%) 0.2
CVD 13 (2.6%) 6 (2.3%) 3 (8.8%) 0.12
TBQ-EPOC 43 (8.7%) 18 (7.0%) 2 (5.9%) 0.7
TVP-TEP 2 (0.4%) 1 (0.4%) 0 (0%) >0.9
Cancer 5 (1.0%) 1 (0.4%) 1 (2.9%) 0.3
HIV 6 (1.2%) 1 (0.4%) 0 (0%) 0.6
Trombofilia 1 (0.2%) 1 (0.4%) 0 (0%) >0.9
Atrial_fibrillation 3 (0.6%) 0 (0%) 0 (0%) 0.6
Renal_insufficiency 3 (0.6%) 1 (0.4%) 0 (0%) >0.9

1 n (%)

2 Pearson's Chi-squared test; Fisher's exact test

Valores de laboratorio (frecuencia)

Characteristic N = 7771
Lab_anormal 243 (31%)
Anemia 3 (0.4%)
Dimero D 81 (10%)
Leucocitosis 2 (0.3%)
VSG_elevada 72 (9.3%)
LDH_elevada 74 (9.5%)
Eosinopenia 12 (1.5%)
Linfopenia 46 (5.9%)
Plaquetopenia 18 (2.3%)
CPK_elevada 8 (1.0%)
PCR_elevada 146 (19%)
Hiperprot_LCR 3 (0.4%)
Ferritina 38 (4.9%)
FR_anormal 25 (3.2%)
Ferrit 73 (9.4%)
Transaminasas 46 (5.9%)
Linfocitosis 1 (0.1%)
Fibrinogeno_elevado 3 (0.4%)
Hiperglucemia 1 (0.1%)
Hipoalbuminemia 4 (0.5%)
neurocovid_severity
mild 491 (63%)
moderate 257 (33%)
severe 29 (3.7%)

1 n (%)

Valores de laboratorio por severidad

Characteristic mild, N = 4911 moderate, N = 2571 severe, N = 291 p-value2
Lab_anormal 202 (41%) 39 (15%) 2 (6.9%) <0.001
Anemia 3 (0.6%) 0 (0%) 0 (0%) 0.6
Dimero D 67 (14%) 13 (5.1%) 1 (3.4%) <0.001
Leucocitosis 1 (0.2%) 1 (0.4%) 0 (0%) >0.9
VSG_elevada 51 (10%) 19 (7.4%) 2 (6.9%) 0.4
LDH_elevada 68 (14%) 6 (2.3%) 0 (0%) <0.001
Eosinopenia 8 (1.6%) 4 (1.6%) 0 (0%) >0.9
Linfopenia 34 (6.9%) 11 (4.3%) 1 (3.4%) 0.3
Plaquetopenia 13 (2.6%) 5 (1.9%) 0 (0%) 0.8
CPK_elevada 6 (1.2%) 2 (0.8%) 0 (0%) 0.8
PCR_elevada 125 (25%) 19 (7.4%) 2 (6.9%) <0.001
Hiperprot_LCR 2 (0.4%) 1 (0.4%) 0 (0%) >0.9
Ferritina 35 (7.1%) 3 (1.2%) 0 (0%) <0.001
FR_anormal 21 (4.3%) 4 (1.6%) 0 (0%) 0.12
Ferrit 59 (12%) 14 (5.4%) 0 (0%) 0.002
Transaminasas 39 (7.9%) 7 (2.7%) 0 (0%) 0.006
Linfocitosis 0 (0%) 1 (0.4%) 0 (0%) 0.4
Fibrinogeno_elevado 2 (0.4%) 1 (0.4%) 0 (0%) >0.9
Hiperglucemia 1 (0.2%) 0 (0%) 0 (0%) >0.9
Hipoalbuminemia 3 (0.6%) 1 (0.4%) 0 (0%) >0.9

1 n (%)

2 Pearson's Chi-squared test; Fisher's exact test

Predictores de severidad

## [1] "Model significance"
## [1] 8.227512e-16
## 
## Call:
## glm(formula = Severidad ~ Comorbility + Age2 + Sex + Lab_anormal, 
##     family = binomial, data = base2)
## 
## Deviance Residuals: 
##    Min      1Q  Median      3Q     Max  
## -1.503  -1.051  -0.570   1.215   2.143  
## 
## Coefficients:
##                  Estimate Std. Error z value Pr(>|z|)    
## (Intercept)    -0.9365890  0.2579754  -3.631 0.000283 ***
## ComorbilityYes -0.1925058  0.1932885  -0.996 0.319274    
## Age2            0.2176419  0.0641667   3.392 0.000694 ***
## SexMale         0.0004741  0.1566570   0.003 0.997585    
## Lab_anormalYes -1.6261341  0.2171813  -7.487 7.02e-14 ***
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 1022.4  on 776  degrees of freedom
## Residual deviance:  945.6  on 772  degrees of freedom
##   (7 observations deleted due to missingness)
## AIC: 955.6
## 
## Number of Fisher Scoring iterations: 3

Ajuste del modelo

## Pseudo R-squared for logistic regression model
## 
## Hosmer and Lemeshow R-squared     0.075 
## Cox and Snell R-squared           0.094 
## Nagelkerke R-squared              0.129

OR

##                       OR     2.5 %    97.5 %
## (Intercept)    0.3919625 0.2355836 0.6484882
## ComorbilityYes 0.8248896 0.5634140 1.2033474
## Age2           1.2431418 1.0966708 1.4109185
## SexMale        1.0004743 0.7359516 1.3605687
## Lab_anormalYes 0.1966885 0.1268643 0.2977315