Demographics

Characteristic	N = 784¹
Sex
Male	407 (52%)
Female	377 (48%)
Age	38 (30, 48)
Education
más de 5to grado	582 (74%)
desconocido	187 (24%)
menos de 5to grado	15 (1.9%)
¹ n (%); Median (IQR)

Symptoms by frequency.

Characteristic	N = 784¹
Anosmia	519 (66%)
Ageusia	519 (66%)
Cefalea	539 (69%)
HIP	3 (0.4%)
Stroke	10 (1.3%)
Seizures	3 (0.4%)
Alodinia	139 (18%)
Visual_impairment	4 (0.5%)
Altered_conciusness	16 (2.0%)
Prior_patology_worsening	16 (2.0%)
Mialgia	399 (51%)
Nausea	27 (3.4%)
Neuralgia	3 (0.4%)
Peripheral_neuropathy	27 (3.4%)
Piramidal_signs	2 (0.3%)
Vertigo	28 (3.6%)
Agitation	8 (1.0%)
Ataxia	2 (0.3%)
Ocular_pain	24 (3.1%)
Photofobia	19 (2.4%)
Guillain_Barre	6 (0.8%)
Insomnio	22 (2.8%)
Mielitis	1 (0.1%)
Bells_palsy	1 (0.1%)
Plexopatia	2 (0.3%)
Sincope	3 (0.4%)
Tongue_parestesias	5 (0.6%)
Disejecutive_snd	4 (0.5%)
Meningeal_signs	7 (0.9%)
Miopatia	7 (0.9%)
Astenia	47 (6.0%)
Hypoacusia	4 (0.5%)
Mioclono_grl	2 (0.3%)
Sleep_disorders_motor	3 (0.4%)
Gait_disorder	2 (0.3%)
neurocovid_severity
mild	493 (63%)
moderate	257 (33%)
severe	34 (4.3%)
¹ n (%)

Symptoms by severity.

Characteristic	mild, N = 493¹	moderate, N = 257¹	severe, N = 34¹	p-value²
Anosmia	309 (63%)	191 (74%)	19 (56%)	0.003
Ageusia	309 (63%)	191 (74%)	19 (56%)	0.003
Cefalea	327 (66%)	192 (75%)	20 (59%)	0.028
HIP	0 (0%)	1 (0.4%)	2 (5.9%)	0.002
Stroke	3 (0.6%)	6 (2.3%)	1 (2.9%)	0.066
Seizures	2 (0.4%)	0 (0%)	1 (2.9%)	0.11
Alodinia	60 (12%)	73 (28%)	6 (18%)	<0.001
Visual_impairment	2 (0.4%)	1 (0.4%)	1 (2.9%)	0.2
Altered_conciusness	6 (1.2%)	6 (2.3%)	4 (12%)	0.003
Prior_patology_worsening	13 (2.6%)	2 (0.8%)	1 (2.9%)	0.13
Mialgia	246 (50%)	140 (54%)	13 (38%)	0.2
Nausea	12 (2.4%)	12 (4.7%)	3 (8.8%)	0.056
Neuralgia	1 (0.2%)	2 (0.8%)	0 (0%)	0.4
Peripheral_neuropathy	10 (2.0%)	13 (5.1%)	4 (12%)	0.004
Piramidal_signs	1 (0.2%)	0 (0%)	1 (2.9%)	0.085
Vertigo	11 (2.2%)	16 (6.2%)	1 (2.9%)	0.018
Agitation	4 (0.8%)	3 (1.2%)	1 (2.9%)	0.3
Ataxia	0 (0%)	1 (0.4%)	1 (2.9%)	0.030
Ocular_pain	12 (2.4%)	9 (3.5%)	3 (8.8%)	0.093
Photofobia	4 (0.8%)	11 (4.3%)	4 (12%)	<0.001
Guillain_Barre	2 (0.4%)	2 (0.8%)	2 (5.9%)	0.018
Insomnio	9 (1.8%)	11 (4.3%)	2 (5.9%)	0.049
Mielitis	1 (0.2%)	0 (0%)	0 (0%)	>0.9
Bells_palsy	1 (0.2%)	0 (0%)	0 (0%)	>0.9
Plexopatia	1 (0.2%)	1 (0.4%)	0 (0%)	>0.9
Sincope	1 (0.2%)	2 (0.8%)	0 (0%)	0.4
Tongue_parestesias	1 (0.2%)	4 (1.6%)	0 (0%)	0.11
Disejecutive_snd	1 (0.2%)	2 (0.8%)	1 (2.9%)	0.063
Meningeal_signs	1 (0.2%)	3 (1.2%)	3 (8.8%)	<0.001
Miopatia	3 (0.6%)	4 (1.6%)	0 (0%)	0.4
Astenia	21 (4.3%)	25 (9.7%)	1 (2.9%)	0.011
Hypoacusia	0 (0%)	4 (1.6%)	0 (0%)	0.028
Mioclono_grl	0 (0%)	0 (0%)	2 (5.9%)	0.002
Sleep_disorders_motor	0 (0%)	1 (0.4%)	2 (5.9%)	0.002
Gait_disorder	1 (0.2%)	1 (0.4%)	0 (0%)	>0.9
Comorbility	169 (34%)	59 (23%)	14 (41%)	0.003
¹ n (%) ² Pearson's Chi-squared test; Fisher's exact test

Comorbilities frequency

Characteristic	N = 784¹
Comorbility	242 (31%)
Overweigth/Obesity	48 (6.1%)
HTA	93 (12%)
Asma	9 (1.1%)
Thyroid_disorders	9 (1.1%)
Dyslipemia	23 (2.9%)
Autoinmune_disorders/Inmunesupresion	9 (1.1%)
Diabetes	29 (3.7%)
Pregnancy	7 (0.9%)
CVD	22 (2.8%)
TBQ-EPOC	63 (8.0%)
TVP-TEP	3 (0.4%)
Cancer	7 (0.9%)
HIV	7 (0.9%)
Trombofilia	2 (0.3%)
Atrial_fibrillation	3 (0.4%)
Renal_insufficiency	4 (0.5%)
¹ n (%)

comorbility by severity

Characteristic	mild, N = 493¹	moderate, N = 257¹	severe, N = 34¹	p-value²
Comorbility	169 (34%)	59 (23%)	14 (41%)	0.003
Overweigth/Obesity	42 (8.5%)	5 (1.9%)	1 (2.9%)	<0.001
HTA	60 (12%)	29 (11%)	4 (12%)	>0.9
Asma	5 (1.0%)	3 (1.2%)	1 (2.9%)	0.5
Thyroid_disorders	7 (1.4%)	1 (0.4%)	1 (2.9%)	0.2
Dyslipemia	20 (4.1%)	3 (1.2%)	0 (0%)	0.062
Autoinmune_disorders/Inmunesupresion	6 (1.2%)	2 (0.8%)	1 (2.9%)	0.4
Diabetes	23 (4.7%)	4 (1.6%)	2 (5.9%)	0.043
Pregnancy	7 (1.4%)	0 (0%)	0 (0%)	0.2
CVD	13 (2.6%)	6 (2.3%)	3 (8.8%)	0.12
TBQ-EPOC	43 (8.7%)	18 (7.0%)	2 (5.9%)	0.7
TVP-TEP	2 (0.4%)	1 (0.4%)	0 (0%)	>0.9
Cancer	5 (1.0%)	1 (0.4%)	1 (2.9%)	0.3
HIV	6 (1.2%)	1 (0.4%)	0 (0%)	0.6
Trombofilia	1 (0.2%)	1 (0.4%)	0 (0%)	>0.9
Atrial_fibrillation	3 (0.6%)	0 (0%)	0 (0%)	0.6
Renal_insufficiency	3 (0.6%)	1 (0.4%)	0 (0%)	>0.9
¹ n (%) ² Pearson's Chi-squared test; Fisher's exact test

Comorbilities between Neurocovid and non-Neurocovid groups

Characteristic	Neurocovid symptoms		p-value²
Characteristic	No, N = 32¹	Yes, N = 784¹	p-value²
Comorbility	19 (59%)	242 (31%)	<0.001
Overweigth/Obesity	1 (3.1%)	48 (6.1%)	0.7
HTA	10 (31%)	93 (12%)	0.004
Asma	0 (0%)	9 (1.1%)	>0.9
Thyroid_disorders	1 (3.1%)	9 (1.1%)	0.3
Dyslipemia	6 (19%)	23 (2.9%)	<0.001
Autoinmune_disorders/Inmunesupresion	2 (6.2%)	9 (1.1%)	0.066
Diabetes	1 (3.1%)	29 (3.7%)	>0.9
Pregnancy	0 (0%)	7 (0.9%)	>0.9
CVD	8 (25%)	22 (2.8%)	<0.001
TBQ-EPOC	8 (25%)	63 (8.0%)	0.004
TVP-TEP	0 (0%)	3 (0.4%)	>0.9
Cancer	3 (9.4%)	7 (0.9%)	0.005
HIV	0 (0%)	7 (0.9%)	>0.9
Trombofilia	0 (0%)	2 (0.3%)	>0.9
Atrial_fibrillation	0 (0%)	3 (0.4%)	>0.9
Renal_insufficiency	2 (6.2%)	4 (0.5%)	0.020
¹ n (%) ² Pearson's Chi-squared test; Fisher's exact test

Modelo predictivo sobre factores de riesgo de neurocovid

(para esto use el grupo de datos que estaba mal cargado, podemos discutir los hallazgos -tengo mi opinion al respecto-)

## [1] "Model significance"

## [1] 0.0001039261

## 
## Call:
## glm(formula = Neurocovid ~ Comorbility + `Overweigth/Obesity` + 
##     HTA + Asma + Thyroid_disorders + Dyslipemia + `Autoinmune_disorders/Inmunesupresion` + 
##     Diabetes + Pregnancy + CVD + `TBQ-EPOC` + `TVP-TEP` + Cancer + 
##     HIV + Trombofilia + Atrial_fibrillation + Renal_insufficiency, 
##     family = binomial, data = base)
## 
## Deviance Residuals: 
##     Min       1Q   Median       3Q      Max  
## -2.7401   0.2177   0.2177   0.2177   1.6100  
## 
## Coefficients:
##                                             Estimate Std. Error z value
## (Intercept)                                  3.73032    0.28066  13.291
## ComorbilityYes                               0.38686    0.76481   0.506
## `Overweigth/Obesity`Yes                      2.19014    1.28737   1.701
## HTAYes                                      -0.75742    0.62750  -1.207
## AsmaYes                                     14.17538 2116.64187   0.007
## Thyroid_disordersYes                        -1.99233    1.27131  -1.567
## DyslipemiaYes                               -1.85761    0.69920  -2.657
## `Autoinmune_disorders/Inmunesupresion`Yes   -2.63992    1.03348  -2.554
## DiabetesYes                                  1.27718    1.18400   1.079
## PregnancyYes                                14.44889 2465.32577   0.006
## CVDYes                                      -2.10810    0.68051  -3.098
## `TBQ-EPOC`Yes                               -1.12780    0.64227  -1.756
## `TVP-TEP`Yes                                14.94073 3697.55681   0.004
## CancerYes                                   -1.19929    1.03064  -1.164
## HIVYes                                      15.40246 2285.00629   0.007
## TrombofiliaYes                              14.44889 4612.20205   0.003
## Atrial_fibrillationYes                      15.20631 3765.84720   0.004
## Renal_insufficiencyYes                       0.04167    1.29153   0.032
##                                           Pr(>|z|)    
## (Intercept)                                < 2e-16 ***
## ComorbilityYes                             0.61298    
## `Overweigth/Obesity`Yes                    0.08889 .  
## HTAYes                                     0.22742    
## AsmaYes                                    0.99466    
## Thyroid_disordersYes                       0.11708    
## DyslipemiaYes                              0.00789 ** 
## `Autoinmune_disorders/Inmunesupresion`Yes  0.01064 *  
## DiabetesYes                                0.28072    
## PregnancyYes                               0.99532    
## CVDYes                                     0.00195 ** 
## `TBQ-EPOC`Yes                              0.07910 .  
## `TVP-TEP`Yes                               0.99678    
## CancerYes                                  0.24457    
## HIVYes                                     0.99462    
## TrombofiliaYes                             0.99750    
## Atrial_fibrillationYes                     0.99678    
## Renal_insufficiencyYes                     0.97426    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 270.00  on 815  degrees of freedom
## Residual deviance: 222.55  on 798  degrees of freedom
## AIC: 258.55
## 
## Number of Fisher Scoring iterations: 17

```

Neurocovid_sna

Ismael Calandri

1/2/2021

Demographics

Symptoms by frequency.

Symptoms by severity.

Comorbilities frequency

comorbility by severity

Comorbilities between Neurocovid and non-Neurocovid groups

Modelo predictivo sobre factores de riesgo de neurocovid