Tabla descriptiva 4 grupos: profx, tto, up, down.
Comparativa segun dosis HBPM primeras 48h UCI y su evolucion
|
n
|
269
|
462
|
40
|
11
|
|
|
DD (median [IQR])
|
2185.50 [800.00, 5932.50]
|
2029.00 [933.25, 7629.00]
|
7679.00 [1345.00, 14560.00]
|
6069.50 [1533.75, 17146.50]
|
0.392
|
|
age (median [IQR])
|
63.00 [56.00, 71.00]
|
63.50 [56.00, 71.00]
|
66.00 [58.00, 72.00]
|
66.00 [64.00, 71.00]
|
0.235
|
|
sex = mujer (%)
|
92 (34.3)
|
149 (32.4)
|
10 (25.0)
|
2 ( 18.2)
|
0.214
|
|
diasdesint_hosp (median [IQR])
|
7.00 [5.00, 9.00]
|
7.00 [5.00, 9.00]
|
7.00 [4.00, 9.00]
|
7.00 [5.25, 8.75]
|
0.069
|
|
diasdesint_uci (median [IQR])
|
9.00 [7.00, 13.00]
|
10.00 [7.00, 13.00]
|
9.50 [7.00, 12.25]
|
9.00 [8.50, 10.00]
|
0.181
|
|
apache (mean (SD))
|
19.09 (29.19)
|
18.33 (29.98)
|
21.47 (37.11)
|
18.57 (10.08)
|
0.055
|
|
sofa (mean (SD))
|
6.98 (3.11)
|
7.14 (3.36)
|
6.59 (2.86)
|
7.50 (2.20)
|
0.173
|
|
curb (mean (SD))
|
1.92 (1.10)
|
2.13 (1.22)
|
1.91 (0.97)
|
2.57 (1.51)
|
0.287
|
|
pafi3 (%)
|
|
|
|
|
0.497
|
|
(41,100]
|
26 (10.5)
|
71 (15.9)
|
8 (20.5)
|
0 ( 0.0)
|
|
|
(100,200]
|
146 (58.9)
|
227 (50.8)
|
25 (64.1)
|
5 ( 62.5)
|
|
|
(200,486]
|
76 (30.6)
|
149 (33.3)
|
6 (15.4)
|
3 ( 37.5)
|
|
|
ferritina (median [IQR])
|
1519.00 [794.00, 3714.00]
|
1613.00 [907.00, 3654.50]
|
3601.00 [1210.00, 9764.00]
|
1694.00 [1118.50, 2033.00]
|
0.223
|
|
pcr (median [IQR])
|
19.87 [10.02, 56.50]
|
44.75 [16.22, 196.00]
|
21.75 [12.09, 35.08]
|
23.05 [10.74, 30.74]
|
0.353
|
|
linfocito (mean (SD))
|
0.88 (0.78)
|
1.02 (1.15)
|
0.82 (0.43)
|
1.19 (0.92)
|
0.254
|
|
ratio_pcrlinf (median [IQR])
|
31.10 [13.30, 80.81]
|
66.67 [17.56, 254.75]
|
28.29 [13.11, 86.23]
|
24.02 [10.86, 42.73]
|
0.334
|
|
ilk6 (median [IQR])
|
866.00 [133.50, 1847.00]
|
448.00 [167.00, 1725.00]
|
347.00 [173.50, 441.50]
|
NA [NA, NA]
|
NA
|
|
plaq (mean (SD))
|
566.03 (853.28)
|
1223.34 (11123.26)
|
746.19 (1290.38)
|
620.82 (833.32)
|
0.094
|
|
ventm = si (%)
|
212 (78.8)
|
423 (91.6)
|
35 (87.5)
|
11 (100.0)
|
0.405
|
|
hf_1intencion = si (%)
|
14 ( 5.2)
|
15 ( 3.2)
|
2 ( 5.0)
|
0 ( 0.0)
|
0.185
|
|
man_reclutamiento = si (%)
|
133 (49.4)
|
297 (64.3)
|
25 (62.5)
|
4 ( 36.4)
|
0.333
|
|
prono = si (%)
|
170 (63.2)
|
355 (76.8)
|
32 (80.0)
|
9 ( 81.8)
|
0.226
|
|
ttoreljmusc = si (%)
|
169 (62.8)
|
347 (75.1)
|
32 (80.0)
|
10 ( 90.9)
|
0.370
|
|
ecmo = si (%)
|
3 ( 1.1)
|
7 ( 1.5)
|
1 ( 2.5)
|
0 ( 0.0)
|
0.127
|
|
elim_extraco2r = si (%)
|
5 ( 1.9)
|
9 ( 1.9)
|
1 ( 2.5)
|
0 ( 0.0)
|
0.118
|
|
rempl_renal = si (%)
|
26 ( 9.7)
|
61 (13.2)
|
6 (15.0)
|
1 ( 9.1)
|
0.110
|
|
aclara_creatinina (median [IQR])
|
90.00 [41.29, 90.00]
|
49.50 [1.35, 90.00]
|
1.05 [0.98, 1.23]
|
60.10 [60.10, 60.10]
|
NA
|
|
lap_ritonavir = si (%)
|
155 (57.6)
|
278 (60.2)
|
19 (47.5)
|
7 ( 63.6)
|
0.173
|
|
cloroquina = si (%)
|
232 (86.2)
|
415 (89.8)
|
37 (92.5)
|
10 ( 90.9)
|
0.108
|
|
rendesivir = si (%)
|
7 ( 2.6)
|
14 ( 3.0)
|
1 ( 2.5)
|
0 ( 0.0)
|
0.129
|
|
interf = si (%)
|
53 (19.7)
|
119 (25.8)
|
8 (20.0)
|
0 ( 0.0)
|
0.422
|
|
tozi = si (%)
|
112 (41.6)
|
227 (49.1)
|
21 (52.5)
|
4 ( 36.4)
|
0.189
|
|
azitro = si (%)
|
204 (75.8)
|
341 (73.8)
|
31 (77.5)
|
8 ( 72.7)
|
0.063
|
|
corticoides = si (%)
|
210 (78.1)
|
375 (81.2)
|
36 (90.0)
|
8 ( 72.7)
|
0.240
|
|
ttovascular = si (%)
|
261 (97.0)
|
453 (98.1)
|
39 (97.5)
|
11 (100.0)
|
0.134
|
|
ttoneo = si (%)
|
33 (12.3)
|
39 ( 8.4)
|
4 (10.0)
|
1 ( 9.1)
|
0.068
|
|
ttoacoag = si (%)
|
18 ( 6.7)
|
27 ( 5.8)
|
3 ( 7.5)
|
0 ( 0.0)
|
0.211
|
|
complica_hemo = TRUE (%)
|
29 (10.8)
|
49 (10.6)
|
6 (15.0)
|
2 ( 18.2)
|
0.130
|
|
complica_trombe = TRUE (%)
|
22 ( 8.2)
|
49 (10.6)
|
7 (17.5)
|
0 ( 0.0)
|
0.354
|
|
muere = si (%)
|
70 (26.0)
|
162 (35.1)
|
13 (32.5)
|
5 ( 45.5)
|
0.215
|
Mortalidad, tto vs profilaxis:
Mortalidad, Odds Ratio (sexo, edad, log(DD), 2 grupos dosis)
|
Variable
|
Units
|
OddsRatio
|
CI.95
|
p-value
|
|
sex
|
hombre
|
Ref
|
|
|
|
|
mujer
|
1.52
|
[1.03;2.22]
|
0.0332482
|
|
age
|
|
1.04
|
[1.02;1.05]
|
0.0001748
|
|
log(DD)
|
|
1.38
|
[1.19;1.61]
|
< 1e-04
|
|
grupo
|
profilaxis
|
Ref
|
|
|
|
|
tto
|
1.71
|
[1.15;2.53]
|
0.0074758
|
Mortalidad, Odds Ratio (sexo, edad, log(DD), sofa, 2 grupos dosis, sofa)
|
Variable
|
Units
|
OddsRatio
|
CI.95
|
p-value
|
|
sex
|
hombre
|
Ref
|
|
|
|
|
mujer
|
1.65
|
[1.06;2.57]
|
0.0269995
|
|
age
|
|
1.04
|
[1.02;1.06]
|
0.0004493
|
|
log(DD)
|
|
1.40
|
[1.17;1.69]
|
0.0003255
|
|
grupo
|
profilaxis
|
Ref
|
|
|
|
|
tto
|
1.40
|
[0.89;2.19]
|
0.1453912
|
|
sofa
|
|
1.10
|
[1.04;1.18]
|
0.0025395
|
Mortalidad, Odds Ratio (sexo, edad, log(DD), sofa, prono, 2 grupos dosis)
|
Variable
|
Units
|
OddsRatio
|
CI.95
|
p-value
|
|
sex
|
hombre
|
Ref
|
|
|
|
|
mujer
|
1.68
|
[1.07;2.64]
|
0.0243013
|
|
age
|
|
1.04
|
[1.02;1.07]
|
0.0001694
|
|
log(DD)
|
|
1.37
|
[1.14;1.65]
|
0.0008897
|
|
sofa
|
|
1.11
|
[1.04;1.19]
|
0.0016308
|
|
prono
|
no
|
Ref
|
|
|
|
|
si
|
2.97
|
[1.71;5.15]
|
0.0001138
|
|
grupo
|
profilaxis
|
Ref
|
|
|
|
|
tto
|
1.16
|
[0.73;1.85]
|
0.5291130
|
Mortalidad, Odds Ratio (sexo, edad, log(DD),sofa, prono, corticoides, 2 grupos dosis)
|
Variable
|
Units
|
OddsRatio
|
CI.95
|
p-value
|
|
sex
|
hombre
|
Ref
|
|
|
|
|
mujer
|
1.68
|
[1.08;2.62]
|
0.0226995
|
|
age
|
|
1.04
|
[1.02;1.06]
|
0.0007524
|
|
log(DD)
|
|
1.39
|
[1.16;1.67]
|
0.0004836
|
|
sofa
|
|
1.11
|
[1.04;1.19]
|
0.0013531
|
|
corticoides
|
no
|
Ref
|
|
|
|
|
si
|
1.87
|
[0.93;3.75]
|
0.0794030
|
|
grupo
|
profilaxis
|
Ref
|
|
|
|
|
tto
|
1.34
|
[0.85;2.11]
|
0.2016193
|
Complicaciones tromboticas:
Complicaciones trombotica, Odds Ratio (sexo, edad, log(DD), 2 grupos dosis)
|
Variable
|
Units
|
OddsRatio
|
CI.95
|
p-value
|
|
sex
|
hombre
|
Ref
|
|
|
|
|
mujer
|
0.32
|
[0.15;0.70]
|
0.004306
|
|
age
|
|
1.00
|
[0.97;1.03]
|
0.963658
|
|
log(DD)
|
|
1.44
|
[1.14;1.81]
|
0.002047
|
|
grupo
|
profilaxis
|
Ref
|
|
|
|
|
tto
|
1.14
|
[0.63;2.07]
|
0.669254
|
Complicaciones hemorragicas:
Complicaciones hemorragicas, Odds Ratio (sexo, edad, log(DD), 2 grupos dosis)
|
Variable
|
Units
|
OddsRatio
|
CI.95
|
p-value
|
|
sex
|
hombre
|
Ref
|
|
|
|
|
mujer
|
0.79
|
[0.45;1.40]
|
0.41735
|
|
age
|
|
1.03
|
[1.00;1.06]
|
0.02676
|
|
log(DD)
|
|
1.25
|
[1.01;1.55]
|
0.03814
|
|
grupo
|
profilaxis
|
Ref
|
|
|
|
|
tto
|
1.07
|
[0.62;1.86]
|
0.79569
|