Visualization of DLQI Mixed Models Results by Agustin Calatroni

Figure

Table

Phase 3 Randomized Clinical Trial Mixed-Model Results evaluating quality of life DLQI Total Scale & Individual Subscales
Standardized Effects (95% CI) and Standardized Differences (95% CI) and p-values
LAB	Placebo		Active		Within TRT between VISIT		Overall
	Baseline	Week 16	Baseline	Week 16	Placebo	Active	Difference
Influenced Clothes You Wear DLQI104	2.19 (1.94, 2.43)	1.92 (1.68, 2.16)	2.23 (2.03, 2.42)	0.74 (0.57, 0.90)	−0.26 (−0.50, −0.03) p=0.025	−1.49 (−1.67, −1.31) p<0.001	−1.22 (−1.52, −0.93) p<0.001
How Embarrassed, Self Conscious DLQI102	2.31 (2.06, 2.55)	2.28 (2.03, 2.53)	2.36 (2.16, 2.55)	0.77 (0.62, 0.93)	−0.03 (−0.26, 0.21) p=0.83	−1.58 (−1.76, −1.40) p<0.001	−1.56 (−1.85, −1.26) p<0.001
How Itchy, Sore, Painful, Stinging DLQI101	2.84 (2.61, 3.08)	2.64 (2.41, 2.88)	2.93 (2.73, 3.13)	1.23 (1.09, 1.38)	−0.20 (−0.43, 0.03) p=0.084	−1.70 (−1.88, −1.51) p<0.001	−1.49 (−1.79, −1.20) p<0.001
How Much a Problem is Treatment DLQI110	1.21 (1.00, 1.41)	1.09 (0.89, 1.30)	1.29 (1.14, 1.44)	0.27 (0.13, 0.41)	−0.11 (−0.34, 0.12) p=0.35	−1.02 (−1.19, −0.85) p<0.001	−0.91 (−1.20, −0.62) p<0.001
DLQI Total Score DLQI_SCORE	2.32 (2.07, 2.56)	2.02 (1.78, 2.27)	2.37 (2.18, 2.57)	0.67 (0.51, 0.83)	−0.29 (−0.52, −0.06) p=0.014	−1.70 (−1.89, −1.52) p<0.001	−1.41 (−1.70, −1.12) p<0.001
Affected Social, Leisure Activity DLQI105	1.66 (1.44, 1.89)	1.15 (0.93, 1.37)	1.54 (1.37, 1.70)	0.33 (0.18, 0.48)	−0.51 (−0.74, −0.28) p<0.001	−1.20 (−1.38, −1.03) p<0.001	−0.70 (−0.98, −0.41) p<0.001
Interfered Shopping, Home, Yard DLQI103	1.13 (0.93, 1.34)	0.92 (0.71, 1.12)	1.22 (1.07, 1.38)	0.20 (0.06, 0.35)	−0.21 (−0.44, 0.02) p=0.071	−1.02 (−1.19, −0.85) p<0.001	−0.81 (−1.09, −0.52) p<0.001
Made It Difficult to Do Any Sports DLQI106	1.23 (1.01, 1.45)	1.01 (0.79, 1.23)	1.19 (1.03, 1.35)	0.26 (0.11, 0.41)	−0.22 (−0.45, 0.01) p=0.060	−0.93 (−1.10, −0.76) p<0.001	−0.71 (−0.99, −0.42) p<0.001
Caused Any Sexual Difficulties DLQI109	0.99 (0.78, 1.19)	0.79 (0.58, 1.00)	0.92 (0.77, 1.07)	0.18 (0.04, 0.33)	−0.19 (−0.42, 0.04) p=0.10	−0.73 (−0.90, −0.56) p<0.001	−0.54 (−0.83, −0.26) p<0.001
Problem Partner, Friends, Relative DLQI108	1.05 (0.84, 1.25)	0.86 (0.65, 1.07)	1.17 (1.01, 1.32)	0.27 (0.13, 0.41)	−0.19 (−0.42, 0.04) p=0.11	−0.90 (−1.07, −0.73) p<0.001	−0.71 (−0.99, −0.42) p<0.001
Prevented Working or Studying DLQI107	0.37 (0.20, 0.55)	0.28 (0.10, 0.46)	0.54 (0.42, 0.67)	0.05 (−0.08, 0.18)	−0.09 (−0.32, 0.14) p=0.44	−0.50 (−0.66, −0.33) p<0.001	−0.41 (−0.69, −0.12) p=0.005

Table (Raw)

Phase 3 Randomized Clinical Trial Mixed-Model Results evaluating quality of life DLQI Total Scale & Individual Subscales
Effects (95% CI) and Differences (95% CI) and p-values
LAB	Placebo		Active		Within TRT between VISIT		Overall
	Baseline	Week 16	Baseline	Week 16	Placebo	Active	Difference
Influenced Clothes You Wear DLQI104	1.63 (1.47, 1.79)	1.44 (1.27, 1.60)	1.66 (1.55, 1.78)	0.55 (0.43, 0.67)	−0.20 (−0.37, −0.03) p=0.025	−1.11 (−1.24, −0.99) p<0.001	−0.92 (−1.13, −0.70) p<0.001
How Embarrassed, Self Conscious DLQI102	1.61 (1.46, 1.76)	1.60 (1.44, 1.75)	1.65 (1.54, 1.75)	0.54 (0.43, 0.65)	−0.02 (−0.18, 0.14) p=0.83	−1.10 (−1.22, −0.99) p<0.001	−1.09 (−1.29, −0.89) p<0.001
How Itchy, Sore, Painful, Stinging DLQI101	1.97 (1.85, 2.10)	1.83 (1.70, 1.96)	2.03 (1.94, 2.12)	0.86 (0.76, 0.95)	−0.14 (−0.30, 0.02) p=0.083	−1.18 (−1.29, −1.06) p<0.001	−1.04 (−1.23, −0.84) p<0.001
How Much a Problem is Treatment DLQI110	0.88 (0.74, 1.02)	0.80 (0.65, 0.94)	0.94 (0.84, 1.04)	0.20 (0.09, 0.30)	−0.08 (−0.25, 0.09) p=0.35	−0.75 (−0.87, −0.63) p<0.001	−0.67 (−0.87, −0.46) p<0.001
DLQI Total Score DLQI_SCORE	10.57 (9.60, 11.54)	9.24 (8.25, 10.23)	10.83 (10.14, 11.52)	3.06 (2.36, 3.77)	−1.33 (−2.38, −0.28) p=0.013	−7.77 (−8.52, −7.02) p<0.001	−6.44 (−7.73, −5.15) p<0.001
Affected Social, Leisure Activity DLQI105	1.11 (0.97, 1.24)	0.77 (0.63, 0.91)	1.02 (0.93, 1.12)	0.22 (0.12, 0.32)	−0.34 (−0.49, −0.18) p<0.001	−0.80 (−0.91, −0.69) p<0.001	−0.46 (−0.65, −0.27) p<0.001
Interfered Shopping, Home, Yard DLQI103	0.74 (0.61, 0.87)	0.60 (0.47, 0.73)	0.80 (0.71, 0.89)	0.13 (0.04, 0.23)	−0.14 (−0.29, 0.01) p=0.070	−0.67 (−0.77, −0.56) p<0.001	−0.53 (−0.71, −0.34) p<0.001
Made It Difficult to Do Any Sports DLQI106	0.82 (0.68, 0.96)	0.67 (0.53, 0.81)	0.79 (0.69, 0.89)	0.17 (0.07, 0.27)	−0.15 (−0.30, 0.01) p=0.059	−0.62 (−0.73, −0.51) p<0.001	−0.47 (−0.66, −0.28) p<0.001
Caused Any Sexual Difficulties DLQI109	0.61 (0.49, 0.74)	0.49 (0.37, 0.62)	0.57 (0.48, 0.66)	0.11 (0.02, 0.21)	−0.12 (−0.26, 0.02) p=0.10	−0.46 (−0.56, −0.35) p<0.001	−0.34 (−0.51, −0.16) p<0.001
Problem Partner, Friends, Relative DLQI108	0.64 (0.52, 0.76)	0.53 (0.40, 0.65)	0.71 (0.63, 0.80)	0.17 (0.08, 0.25)	−0.11 (−0.26, 0.03) p=0.11	−0.55 (−0.65, −0.45) p<0.001	−0.43 (−0.61, −0.26) p<0.001
Prevented Working or Studying DLQI107	0.26 (0.14, 0.38)	0.20 (0.07, 0.32)	0.38 (0.29, 0.47)	0.03 (−0.06, 0.12)	−0.06 (−0.22, 0.10) p=0.44	−0.35 (−0.46, −0.23) p<0.001	−0.28 (−0.48, −0.09) p=0.005