Variable N Overall, N = 26,5391 CR-POPF vs No CR-POPF p-value2
CR-POPF, N = 4,5101 No CR-POPF, N = 22,0291
Age 26,539 65.00 (56.00, 73.00) 64.00 (55.00, 71.00) 66.00 (57.00, 73.00) <0.001
Sex 26,539 <0.001
female 13,138 (50%) 2,009 (45%) 11,129 (51%)
male 13,401 (50%) 2,501 (55%) 10,900 (49%)
Weight 26,486 169.00 (142.00, 198.00) 180.00 (152.00, 210.00) 167.00 (141.00, 196.00) <0.001
Unknown 53 16 37
Height 26,435 66.00 (63.00, 69.00) 66.00 (63.00, 69.00) 66.00 (63.00, 69.00) <0.001
Unknown 104 27 77
BMI 26,539 26.92 (23.56, 31.01) 28.28 (24.67, 32.61) 26.62 (23.33, 30.68) <0.001
Race 26,539 <0.001
Black 2,261 (8.5%) 314 (7.0%) 1,947 (8.8%)
Other 1,240 (4.7%) 218 (4.8%) 1,022 (4.6%)
Unknown 3,347 (13%) 665 (15%) 2,682 (12%)
White 19,691 (74%) 3,313 (73%) 16,378 (74%)
Smoker 26,539 4,514 (17%) 728 (16%) 3,786 (17%) 0.093
Hypertension 26,539 13,849 (52%) 2,376 (53%) 11,473 (52%) 0.47
DYSPNEA 26,539 0.20
AT REST 36 (0.1%) 7 (0.2%) 29 (0.1%)
MODERATE EXERTION 1,372 (5.2%) 257 (5.7%) 1,115 (5.1%)
No 25,131 (95%) 4,246 (94%) 20,885 (95%)
DIABETES 26,539 6,847 (26%) 961 (21%) 5,886 (27%) <0.001
Ascites 26,539 76 (0.3%) 13 (0.3%) 63 (0.3%) >0.99
Hx of CHF 30 Prior to Surgery 26,539 109 (0.4%) 21 (0.5%) 88 (0.4%) 0.61
DIALYSIS 26,539 106 (0.4%) 12 (0.3%) 94 (0.4%) 0.15
HXCOPD 26,539 1,066 (4.0%) 201 (4.5%) 865 (3.9%) 0.11
ASA Classification 26,539 0.026
5-Moribund 14 (<0.1%) 2 (<0.1%) 12 (<0.1%)
I-II 6,562 (25%) 1,171 (26%) 5,391 (24%)
III-IV 19,939 (75%) 3,329 (74%) 16,610 (75%)
None assigned 24 (<0.1%) 8 (0.2%) 16 (<0.1%)
Pancreatic Duct Diameter 26,539 <0.001
<3 mm 5,540 (21%) 1,281 (28%) 4,259 (19%)
>6 mm 2,582 (9.7%) 248 (5.5%) 2,334 (11%)
3-6 mm 7,584 (29%) 1,096 (24%) 6,488 (29%)
Unknown 10,833 (41%) 1,885 (42%) 8,948 (41%)
Pancreatic Gland Texture 26,539 <0.001
Hard 6,400 (24%) 566 (13%) 5,834 (26%)
Intermediate 1,923 (7.2%) 264 (5.9%) 1,659 (7.5%)
Soft 8,194 (31%) 1,983 (44%) 6,211 (28%)
Unknown 10,022 (38%) 1,697 (38%) 8,325 (38%)
Pancreatic Drain 26,539 <0.001
No 3,402 (13%) 280 (6.2%) 3,122 (14%)
Unknown 38 (0.1%) 4 (<0.1%) 34 (0.2%)
Yes 23,099 (87%) 4,226 (94%) 18,873 (86%)
Pancreatic Drain Placed on Suction 26,539 <0.001
No 2,165 (8.2%) 345 (7.6%) 1,820 (8.3%)
Unknown 9,196 (35%) 1,423 (32%) 7,773 (35%)
Yes 15,178 (57%) 2,742 (61%) 12,436 (56%)
Percutaneous Drain 26,539 3,279 (12%) 1,842 (41%) 1,437 (6.5%) <0.001
Delayed Gastric Emptying 26,539 <0.001
No 23,166 (87%) 3,287 (73%) 19,879 (90%)
Unknown 88 (0.3%) 30 (0.7%) 58 (0.3%)
Yes-no oral intake by POD 14 358 (1.3%) 165 (3.7%) 193 (0.9%)
Yes-tube to external drainage/NG tube present/reinserted 2,927 (11%) 1,028 (23%) 1,899 (8.6%)
PAN_MALIG_HISTOLOGIC 26,539
Ampullary carcinoma 1,252 (4.7%) 311 (6.9%) 941 (4.3%)
Cystadenocarcinoma 20 (<0.1%) 3 (<0.1%) 17 (<0.1%)
Distal cholangiocarcinoma 476 (1.8%) 134 (3.0%) 342 (1.6%)
Duodenal carcinoma 522 (2.0%) 136 (3.0%) 386 (1.8%)
IPMN-invasive 553 (2.1%) 70 (1.6%) 483 (2.2%)
N/A 7,058 (27%) 1,316 (29%) 5,742 (26%)
Neuroendocrine-functioning 667 (2.5%) 160 (3.5%) 507 (2.3%)
Neuroendocrine-nonfunctioning 2,317 (8.7%) 525 (12%) 1,792 (8.1%)
Other type 1,657 (6.2%) 341 (7.6%) 1,316 (6.0%)
Pancreatic adenocarcinoma 11,875 (45%) 1,487 (33%) 10,388 (47%)
Unknown 142 (0.5%) 27 (0.6%) 115 (0.5%)
Unplanned Reoperation 26,539 1,283 (4.8%) 467 (10%) 816 (3.7%) <0.001
Total Operation Time 26,534 306.00 (215.00, 405.00) 317.00 (228.00, 416.00) 304.00 (212.00, 403.00) <0.001
Unknown 5 2 3
Length of Total Hospital Stay 26,342 7.00 (5.00, 11.00) 10.00 (6.00, 17.00) 7.00 (5.00, 10.00) <0.001
Unknown 197 97 100
STILLINHOSP 26,539 569 (2.1%) 296 (6.6%) 273 (1.2%) <0.001
DPRNA 25,782 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 0.39
Unknown 757 129 628
DPRBUN 24,644 8.00 (3.00, 17.00) 8.00 (3.00, 17.00) 8.00 (3.00, 17.00) 0.57
Unknown 1,895 341 1,554
DPRCREAT 25,932 8.00 (3.00, 16.00) 8.00 (3.00, 17.00) 8.00 (3.00, 16.00) 0.86
Unknown 607 104 503
DPRALBUM 23,677 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 0.92
Unknown 2,862 578 2,284
DPRBILI 24,361 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 0.83
Unknown 2,178 404 1,774
DPRSGOT 24,026 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 0.56
Unknown 2,513 476 2,037
DPRALKPH 24,356 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 9.00 (4.00, 19.00) 0.60
Unknown 2,183 395 1,788
DPRWBC 25,924 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 0.70
Unknown 615 108 507
DPRHCT 25,963 7.00 (2.00, 16.00) 7.00 (2.00, 16.00) 7.00 (2.00, 16.00) 0.78
Unknown 576 100 476
DPRPLATE 25,917 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 0.76
Unknown 622 111 511
DPRPTT 15,300 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 8.00 (3.00, 16.00) 0.86
Unknown 11,239 1,807 9,432
DPRPT 67 8.00 (2.50, 22.50) 13.00 (8.00, 21.50) 7.00 (2.00, 22.25) 0.51
Unknown 26,472 4,503 21,969
DPRINR 20,674 8.00 (3.00, 16.00) 8.00 (3.00, 17.00) 8.00 (3.00, 16.00) 0.58
Unknown 5,865 951 4,914
Pre-operative serum sodium 25,782 139.00 (137.00, 141.00) 140.00 (138.00, 141.00) 139.00 (137.00, 141.00) <0.001
Unknown 757 129 628
Pre-operative BUN 24,644 14.00 (11.00, 18.00) 15.00 (11.48, 18.49) 14.00 (11.00, 18.00) 0.002
Unknown 1,895 341 1,554
Pre-operative Creatinine 25,931 0.81 (0.70, 1.00) 0.86 (0.71, 1.00) 0.80 (0.70, 0.99) <0.001
Unknown 608 104 504
Pre-operative Albumin 23,677 3.90 (3.50, 4.30) 4.00 (3.60, 4.30) 3.90 (3.50, 4.30) <0.001
Unknown 2,862 578 2,284
Pre-operative Bilirubin 24,043 0.50 (0.40, 1.00) 0.50 (0.40, 0.90) 0.50 (0.40, 1.00) 0.083
Unknown 2,496 454 2,042
Pre-operative SGOT 24,023 24.00 (18.00, 39.00) 23.00 (18.00, 36.00) 25.00 (18.00, 40.00) <0.001
Unknown 2,516 476 2,040
Pre-operative Alkaline Phosphatase 24,164 95.00 (70.00, 158.00) 89.00 (68.00, 133.00) 96.00 (71.00, 164.00) <0.001
Unknown 2,375 414 1,961
Pre-operative WBC 25,914 6.90 (5.52, 8.50) 7.00 (5.74, 8.60) 6.83 (5.50, 8.50) <0.001
Unknown 625 110 515
Pre-operative Hematocrit 25,960 38.70 (35.00, 41.90) 39.80 (36.10, 42.80) 38.45 (35.00, 41.60) <0.001
Unknown 579 100 479
Pre-operative Platelet Count 25,914 237.00 (190.00, 294.00) 241.00 (195.00, 296.00) 237.00 (189.00, 294.00) 0.002
Unknown 625 111 514
Pre-operative PTT 15,293 29.30 (26.90, 32.00) 29.10 (26.80, 32.00) 29.30 (26.90, 32.00) 0.30
Unknown 11,246 1,808 9,438
Pre-operative International Normalized Ratio (INR) of PT values 20,674 1.00 (1.00, 1.10) 1.00 (1.00, 1.10) 1.00 (1.00, 1.10) 0.058
Unknown 5,865 951 4,914
Pre-operative PT 67 11.00 (10.50, 12.25) 10.70 (10.30, 11.60) 11.05 (10.50, 12.33) 0.40
Unknown 26,472 4,503 21,969

1 Statistics presented: Median (IQR); n (%)

2 Statistical tests performed: Wilcoxon rank-sum test; chi-square test of independence; Fisher's exact test