Variable N Overall, N = 1,7021 Treatment Groups p-value2
Neoadjuvant Multiagent, N = 8341 Neoadjuvant Multiagent Chemotherapy xrt, N = 8681
Age 1,702 62.6193 (9.7819) 62.7530 (9.9763) 62.4908 (9.5954) 0.40
Sex 1,702 0.35
Female 837 (49%) 400 (48%) 437 (50%)
Male 865 (51%) 434 (52%) 431 (50%)
Race 1,702 0.45
Black 120 (7.1%) 65 (7.8%) 55 (6.3%)
Other 76 (4.5%) 39 (4.7%) 37 (4.3%)
White 1,506 (88%) 730 (88%) 776 (89%)
Type of Insurance 1,702 0.63
Medicaid 79 (4.6%) 38 (4.6%) 41 (4.7%)
Medicare 697 (41%) 352 (42%) 345 (40%)
Not Insured 17 (1.0%) 6 (0.7%) 11 (1.3%)
Private Insurance/Managed Care/Goverment 885 (52%) 428 (51%) 457 (53%)
Unknown 24 (1.4%) 10 (1.2%) 14 (1.6%)
Regions 1,702 <0.001
Midwest 456 (27%) 208 (25%) 248 (29%)
Northeast 433 (25%) 220 (26%) 213 (25%)
South 499 (29%) 216 (26%) 283 (33%)
Unknown 24 (1.4%) 14 (1.7%) 10 (1.2%)
West 290 (17%) 176 (21%) 114 (13%)
Income 1,702 0.24
< $38,000 196 (12%) 96 (12%) 100 (12%)
>=$63,000 662 (39%) 321 (38%) 341 (39%)
$38,000-$47,999 362 (21%) 184 (22%) 178 (21%)
$48,000-$62,999 474 (28%) 226 (27%) 248 (29%)
Unknown 8 (0.5%) 7 (0.8%) 1 (0.1%)
No High School Degree 1,702 0.33
<7.0% 541 (32%) 269 (32%) 272 (31%)
>=21.0% 166 (9.8%) 85 (10%) 81 (9.3%)
13.0-20.9% 351 (21%) 171 (21%) 180 (21%)
7.0-12.9% 637 (37%) 303 (36%) 334 (38%)
Unknown 7 (0.4%) 6 (0.7%) 1 (0.1%)
Population Density 1,702 0.56
Metro 1,381 (81%) 677 (81%) 704 (81%)
Rural 33 (1.9%) 14 (1.7%) 19 (2.2%)
Unknown 43 (2.5%) 25 (3.0%) 18 (2.1%)
Urban 245 (14%) 118 (14%) 127 (15%)
Charlson-Deyo Score 1,702 0.085
>=3 34 (2.0%) 10 (1.2%) 24 (2.8%)
0 1,191 (70%) 595 (71%) 596 (69%)
1 397 (23%) 187 (22%) 210 (24%)
2 80 (4.7%) 42 (5.0%) 38 (4.4%)
TNM Clinical T 1,702
c0 1 (<0.1%) 1 (0.1%) 0 (0%)
c1 9 (0.5%) 6 (0.7%) 3 (0.3%)
c2 86 (5.1%) 57 (6.8%) 29 (3.3%)
c3 1,000 (59%) 509 (61%) 491 (57%)
c4 564 (33%) 234 (28%) 330 (38%)
cX 40 (2.4%) 27 (3.2%) 13 (1.5%)
Unknown 2 (0.1%) 0 (0%) 2 (0.2%)
TNM Clinical N 1,702 0.20
c0 1,086 (64%) 532 (64%) 554 (64%)
c1 544 (32%) 261 (31%) 283 (33%)
cX 70 (4.1%) 41 (4.9%) 29 (3.3%)
Unknown 2 (0.1%) 0 (0%) 2 (0.2%)
Clinical Downstaging 1,702 <0.001
No 667 (39%) 405 (49%) 262 (30%)
Unknown 356 (21%) 144 (17%) 212 (24%)
Yes 679 (40%) 285 (34%) 394 (45%)
Surgery Type 1,702 0.47
Pancreatectomy, NOS 16 (0.9%) 9 (1.1%) 7 (0.8%)
Partial pancreatectomy, distal 219 (13%) 97 (12%) 122 (14%)
Total 214 (13%) 112 (13%) 102 (12%)
Unknown 82 (4.8%) 38 (4.6%) 44 (5.1%)
Whipple 1,171 (69%) 578 (69%) 593 (68%)
Surgical Margins 1,702 <0.001
R0 1,264 (74%) 571 (68%) 693 (80%)
R1 197 (12%) 130 (16%) 67 (7.7%)
R2 13 (0.8%) 7 (0.8%) 6 (0.7%)
Unknown 228 (13%) 126 (15%) 102 (12%)
Tumor Grade 1,702 0.043
Moderately differentiated 443 (26%) 242 (29%) 201 (23%)
Poorly differentiated 304 (18%) 147 (18%) 157 (18%)
Unknown 834 (49%) 386 (46%) 448 (52%)
Well differentiated, differentiated 121 (7.1%) 59 (7.1%) 62 (7.1%)

1 Statistics presented: Mean (SD); n (%)

2 Statistical tests performed: Wilcoxon rank-sum test; chi-square test of independence; Fisher's exact test