Variable N Overall, N = 2,3231 Treatment Groups p-value2
Neoadjuvant Multiagent Chemotherapy, N = 1,7001 Postop Multiagent Chemotherapy, N = 6231
Age 2,323 62.37 (9.94) 62.61 (9.78) 61.70 (10.35) 0.026
Sex 2,323 0.33
Female 1,126 (48%) 835 (49%) 291 (47%)
Male 1,197 (52%) 865 (51%) 332 (53%)
Race 2,323 0.22
Black 176 (7.6%) 120 (7.1%) 56 (9.0%)
Other 108 (4.6%) 76 (4.5%) 32 (5.1%)
White 2,039 (88%) 1,504 (88%) 535 (86%)
Type of Insurance 2,323 0.024
Insurance Status Unknown 33 (1.4%) 24 (1.4%) 9 (1.4%)
Medicaid 110 (4.7%) 79 (4.6%) 31 (5.0%)
Medicare 947 (41%) 696 (41%) 251 (40%)
Not Insured 36 (1.5%) 17 (1.0%) 19 (3.0%)
Other Government 34 (1.5%) 24 (1.4%) 10 (1.6%)
Private Insurance/Managed Care 1,163 (50%) 860 (51%) 303 (49%)
Regions 2,323 0.36
Midwest 637 (27%) 456 (27%) 181 (29%)
Northeast 567 (24%) 433 (25%) 134 (22%)
South 686 (30%) 499 (29%) 187 (30%)
Unknown 35 (1.5%) 24 (1.4%) 11 (1.8%)
West 398 (17%) 288 (17%) 110 (18%)
Income 2,323 0.27
< $38,000 288 (12%) 196 (12%) 92 (15%)
>=$63,000 893 (38%) 662 (39%) 231 (37%)
$38,000-$47,999 489 (21%) 360 (21%) 129 (21%)
$48,000-$62,999 644 (28%) 474 (28%) 170 (27%)
Unknown 9 (0.4%) 8 (0.5%) 1 (0.2%)
No High School Degree 2,323 0.043
<7.0% 717 (31%) 540 (32%) 177 (28%)
>=21.0% 241 (10%) 166 (9.8%) 75 (12%)
13.0-20.9% 507 (22%) 351 (21%) 156 (25%)
7.0-12.9% 850 (37%) 636 (37%) 214 (34%)
Unknown 8 (0.3%) 7 (0.4%) 1 (0.2%)
Population Density 2,323 0.55
Metro 1,895 (82%) 1,380 (81%) 515 (83%)
Rural 43 (1.9%) 33 (1.9%) 10 (1.6%)
Unknown 53 (2.3%) 43 (2.5%) 10 (1.6%)
Urban 332 (14%) 244 (14%) 88 (14%)
Charlson-Deyo Disability Score 2,323 0.46
>=3 41 (1.8%) 34 (2.0%) 7 (1.1%)
0 1,634 (70%) 1,189 (70%) 445 (71%)
1 543 (23%) 397 (23%) 146 (23%)
2 105 (4.5%) 80 (4.7%) 25 (4.0%)
TNM Clinical T 2,323
c0 2 (<0.1%) 1 (<0.1%) 1 (0.2%)
c1 35 (1.5%) 9 (0.5%) 26 (4.2%)
c2 184 (7.9%) 86 (5.1%) 98 (16%)
c3 1,227 (53%) 1,000 (59%) 227 (36%)
c4 657 (28%) 564 (33%) 93 (15%)
cX 218 (9.4%) 40 (2.4%) 178 (29%)
TNM Clinical N 2,323 <0.001
c0 1,386 (60%) 1,086 (64%) 300 (48%)
c1 694 (30%) 544 (32%) 150 (24%)
cX 241 (10%) 70 (4.1%) 171 (27%)
Unknown 2 (<0.1%) 0 (0%) 2 (0.3%)
Clinical Downstaging 2,323 <0.001
No 955 (41%) 667 (39%) 288 (46%)
Unknown 670 (29%) 354 (21%) 316 (51%)
Yes 698 (30%) 679 (40%) 19 (3.0%)
Surgery Type 2,323 0.003
Pancreatectomy, NOS 27 (1.2%) 16 (0.9%) 11 (1.8%)
Partial pancreatectomy, distal 311 (13%) 219 (13%) 92 (15%)
Total 279 (12%) 213 (13%) 66 (11%)
Unknown 134 (5.8%) 82 (4.8%) 52 (8.3%)
Whipple 1,572 (68%) 1,170 (69%) 402 (65%)
Surgical Margins 2,323 <0.001
R0 1,559 (67%) 1,262 (74%) 297 (48%)
R1 356 (15%) 197 (12%) 159 (26%)
R2 40 (1.7%) 13 (0.8%) 27 (4.3%)
Unknown 368 (16%) 228 (13%) 140 (22%)
Tumor Grade 2,323 <0.001
Moderately differentiated 679 (29%) 442 (26%) 237 (38%)
Poorly differentiated 521 (22%) 303 (18%) 218 (35%)
Unknown 945 (41%) 834 (49%) 111 (18%)
Well differentiated, differentiated 178 (7.7%) 121 (7.1%) 57 (9.1%)

1 Statistics presented: Mean (SD); n (%)

2 Statistical tests performed: Wilcoxon rank-sum test; chi-square test of independence; Fisher's exact test