Predicción de la Hepatitis C
Máster Big Data y Business Analytics

Introducción

La infección por el virus de la hepatitis C (HCV por sus siglas en inglés) es un problema de salud que afecta a más de 100 millones de personas en el mundo. No obstante, y a pesar de la elevada cifra de afectados, sólo una parte de ellos presentará problemas graves derivados de la persistencia del virus.

La infección aguda por el HCV es habitualmente asintomática y, por tanto, difícil de reconocer.

La prueba del virus de la hepatitis C es un análisis de sangre que detecta material genético del virus que causa la hepatitis o las proteínas que produce el cuerpo contra el HCV. Se utiliza la reacción en cadena de la polimerasa (PCR).

La prueba de la hepatitis C se realiza cuando hay sospecha de infección (bebés nacidos de una madre con hepatitis C, personas en contacto con sangre o agujas infectadas en el trabajo, personas que han tenido más de una pareja sexual en los últimos 6 meses o tienen antecedentes de una enfermedad transmitida sexualmente…)

El objetivo de este trabajo es obtener un modelo para predecir la infección de hepatitis C a partir de los parámetros de un análisis hepático de sangre y, en su caso, el grado de afección.

Descripción de los datos

#Se cargan las librerías iniciales
library(ggplot2)
library(data.table)
library(scatterplot3d)
library(tidyverse)
library(MLmetrics)

La descarga de datos se hace desde la url de UCI

download.file("http://archive.ics.uci.edu/ml/machine-learning-databases/00571/hcvdat0.csv",destfile = "./data/hcvdat.csv")
hcvdat <- read.csv("./data/hcvdat.csv")

Se dispone de un dataset con 615 observaciones procedentes de donantes de sangre y pacientes en las diferentes fases de la enfermedad.

print(hcvdat)
##       X               Category Age Sex  ALB   ALP   ALT   AST   BIL   CHE CHOL   CREA   GGT PROT
## 1     1          0=Blood Donor  32   m 38.5  52.5   7.7  22.1   7.5  6.93 3.23  106.0  12.1 69.0
## 2     2          0=Blood Donor  32   m 38.5  70.3  18.0  24.7   3.9 11.17 4.80   74.0  15.6 76.5
## 3     3          0=Blood Donor  32   m 46.9  74.7  36.2  52.6   6.1  8.84 5.20   86.0  33.2 79.3
## 4     4          0=Blood Donor  32   m 43.2  52.0  30.6  22.6  18.9  7.33 4.74   80.0  33.8 75.7
## 5     5          0=Blood Donor  32   m 39.2  74.1  32.6  24.8   9.6  9.15 4.32   76.0  29.9 68.7
## 6     6          0=Blood Donor  32   m 41.6  43.3  18.5  19.7  12.3  9.92 6.05  111.0  91.0 74.0
## 7     7          0=Blood Donor  32   m 46.3  41.3  17.5  17.8   8.5  7.01 4.79   70.0  16.9 74.5
## 8     8          0=Blood Donor  32   m 42.2  41.9  35.8  31.1  16.1  5.82 4.60  109.0  21.5 67.1
## 9     9          0=Blood Donor  32   m 50.9  65.5  23.2  21.2   6.9  8.69 4.10   83.0  13.7 71.3
## 10   10          0=Blood Donor  32   m 42.4  86.3  20.3  20.0  35.2  5.46 4.45   81.0  15.9 69.9
## 11   11          0=Blood Donor  32   m 44.3  52.3  21.7  22.4  17.2  4.15 3.57   78.0  24.1 75.4
## 12   12          0=Blood Donor  33   m 46.4  68.2  10.3  20.0   5.7  7.36 4.30   79.0  18.7 68.6
## 13   13          0=Blood Donor  33   m 36.3  78.6  23.6  22.0   7.0  8.56 5.38   78.0  19.4 68.7
## 14   14          0=Blood Donor  33   m 39.0  51.7  15.9  24.0   6.8  6.46 3.38   65.0   7.0 70.4
## 15   15          0=Blood Donor  33   m 38.7  39.8  22.5  23.0   4.1  4.63 4.97   63.0  15.2 71.9
## 16   16          0=Blood Donor  33   m 41.8  65.0  33.1  38.0   6.6  8.83 4.43   71.0  24.0 72.7
## 17   17          0=Blood Donor  33   m 40.9  73.0  17.2  22.9  10.0  6.98 5.22   90.0  14.7 72.4
## 18   18          0=Blood Donor  33   m 45.2  88.3  32.4  31.2  10.1  9.78 5.51  102.0  48.5 76.5
## 19   19          0=Blood Donor  33   m 36.6  57.1  38.9  40.3  24.9  9.62 5.50  112.0  27.6 69.3
## 20   20          0=Blood Donor  33   m 42.0  63.1  32.6  34.9  11.2  7.01 4.05  105.0  19.1 68.1
## 21   21          0=Blood Donor  33   m 44.3  49.8  32.1  21.6  13.1  7.44 5.59  103.0  30.2 74.0
## 22   22          0=Blood Donor  33   m 46.7  88.3  23.4  23.9   7.8  9.42 4.62   78.0  29.5 74.3
## 23   23          0=Blood Donor  34   m 42.7  65.3  46.7  30.3  23.4 10.95 5.06   75.0  99.6 69.1
## 24   24          0=Blood Donor  34   m 43.4  46.1  97.8  46.2  11.3  7.99 3.62   71.0  35.3 69.6
## 25   25          0=Blood Donor  34   m 40.5  32.4  29.6  27.1   5.8 10.50 4.56   91.0  26.6 72.0
## 26   26          0=Blood Donor  34   m 44.8  77.7  36.9  31.0  19.5 10.51 5.59   80.0  23.7 78.9
## 27   27          0=Blood Donor  34   m 42.6  27.0  21.4  21.7   7.2  8.15 6.79   85.0  13.9 67.7
## 28   28          0=Blood Donor  34   m 29.0  41.6  29.1  16.1   4.8  6.82 4.03   62.0  14.5 53.2
## 29   29          0=Blood Donor  34   m 44.6  84.1  19.6  29.8   5.8  7.60 5.07   95.0   9.9 71.9
## 30   30          0=Blood Donor  34   m 46.8  61.7  24.5  24.2  23.1 10.99 4.60   83.0  23.8 73.1
## 31   31          0=Blood Donor  34   m 41.8  75.8  30.9  35.5   6.1  9.97 5.94   89.0  48.5 71.3
## 32   32          0=Blood Donor  34   m 46.1  70.6  35.8  30.0   7.6  7.70 4.20   93.0  14.3 78.7
## 33   33          0=Blood Donor  34   m 43.6  58.9  47.1  31.1  18.5  9.14 4.99   95.0  22.2 69.3
## 34   34          0=Blood Donor  35   m 37.5  69.8  37.1  25.0   7.8 11.66 5.73   84.0  27.3 71.0
## 35   35          0=Blood Donor  35   m 42.1  68.3  37.2  56.2  11.1  9.30 4.63   99.0  16.8 73.6
## 36   36          0=Blood Donor  35   m 44.7  79.3  53.5  30.8   9.7 11.39 7.04   88.0  77.3 77.1
## 37   37          0=Blood Donor  35   m 41.5 115.1  24.1  30.4   5.7  9.41 4.33   81.0  22.2 71.3
## 38   38          0=Blood Donor  35   m 48.7  72.7  24.1  31.0  45.1  9.40 3.80   90.0  20.0 75.8
## 39   39          0=Blood Donor  35   m 47.3  92.2  30.7  25.7   6.6 11.58 5.90   82.0  36.9 77.8
## 40   40          0=Blood Donor  35   m 44.5  70.3  26.2  25.1   5.1 10.12 4.69   82.0  20.7 67.2
## 41   41          0=Blood Donor  35   m 47.4  54.5  18.6  21.6  10.3  8.10 6.23   66.0  28.1 74.0
## 42   42          0=Blood Donor  35   m 51.0  82.7  29.3  26.8   8.7 12.32 5.44   89.0  25.0 77.3
## 43   43          0=Blood Donor  35   m 27.8  99.0  30.7  27.8   9.4  6.80 4.27   65.0  40.5 80.7
## 44   44          0=Blood Donor  36   m 46.1  58.5  26.8  25.3   6.0  6.61 5.07   71.0  10.5 79.6
## 45   45          0=Blood Donor  36   m 45.5  57.6  22.5  19.5   7.5  5.28 4.06   88.0  62.5 71.6
## 46   46          0=Blood Donor  36   m 41.7  77.2 103.6  46.9  10.4 12.21 5.63   88.0  20.9 69.3
## 47   47          0=Blood Donor  36   m 45.9  58.8  29.7  27.7  11.7  5.60 4.89   93.0  23.1 70.8
## 48   48          0=Blood Donor  36   m 48.7  65.0  11.5  18.0   7.4  8.02 7.35   69.0  14.2 73.4
## 49   49          0=Blood Donor  36   m 53.0  66.4  40.8  23.2   7.5  8.73 5.81   75.0  36.1 77.3
## 50   50          0=Blood Donor  36   m 47.8  89.0  48.5  38.4   8.6  8.26 5.62   96.0  21.9 76.2
## 51   51          0=Blood Donor  36   m 42.6  65.3  35.8  27.1  15.7 10.66 4.38   96.0  34.7 71.0
## 52   52          0=Blood Donor  36   m 42.4  47.3  23.0  25.5   6.1  9.46 5.29   79.0  17.5 73.8
## 53   53          0=Blood Donor  36   m 48.9  82.8  16.9  24.4   8.9  8.91 5.10   97.0  14.8 79.9
## 54   54          0=Blood Donor  37   m 31.4 106.0  16.6  17.0   2.4  5.95 5.30   68.0  22.9 72.3
## 55   55          0=Blood Donor  37   m 42.9  70.7  16.3  24.1  15.7  9.03 6.80   93.0  70.1 73.4
## 56   56          0=Blood Donor  37   m 44.0  57.4  26.1  24.6   9.7 10.41 6.17   83.0  38.9 76.5
## 57   57          0=Blood Donor  37   m 41.5  64.6  23.7  29.9   9.3  5.49 3.97  100.0  10.4 69.3
## 58   58          0=Blood Donor  37   m 47.9  68.8  40.3  46.9   6.0  9.76 6.42   81.0  22.7 80.6
## 59   59          0=Blood Donor  37   m 44.8  94.3  32.2  36.7   6.3  9.76 4.12  113.0  23.8 72.5
## 60   60          0=Blood Donor  37   m 38.6  61.2  24.6  31.9   7.9  6.02 4.63   72.0  10.3 56.3
## 61   61          0=Blood Donor  37   m 51.2  84.5  18.8  24.7   9.9  8.62 6.59   94.0  25.3 76.3
## 62   62          0=Blood Donor  37   m 41.9  77.5  24.9  25.8   4.1  8.70 4.36   84.0  16.0 71.5
## 63   63          0=Blood Donor  37   m 46.1  44.3  42.7  26.5   6.4 10.86 5.05   74.0  22.2 73.1
## 64   64          0=Blood Donor  37   m 50.4  48.5  19.4  27.5  11.6  5.78 4.93   90.0  27.8 75.0
## 65   65          0=Blood Donor  37   m 33.9  64.0  91.7  44.7   9.1  8.35 5.40   95.0  30.3 74.7
## 66   66          0=Blood Donor  37   m 42.9  61.8  96.1  44.1   9.6  7.82 5.10   82.0  32.3 69.3
## 67   67          0=Blood Donor  37   m 40.8 118.9  17.2  19.2   3.2  9.17 4.26   88.0  13.5 72.0
## 68   68          0=Blood Donor  37   m 43.6  72.8  51.4  43.7  13.8  8.16 4.88   70.0  94.5 75.2
## 69   69          0=Blood Donor  37   m 46.4  53.3  20.2  24.9   8.7  8.63 5.90   86.0  23.3 78.9
## 70   70          0=Blood Donor  37   m 48.7  62.3  21.0  21.1  41.9  9.71 4.02   84.0  16.0 75.1
## 71   71          0=Blood Donor  38   m 48.1  63.2  11.7  14.7   5.1  8.83 3.87   85.0   9.5 73.1
## 72   72          0=Blood Donor  38   m 39.9  62.9  71.7  43.9  10.4 10.90 7.01   99.0  88.3 73.1
## 73   73          0=Blood Donor  38   m 45.5  50.2  16.3  22.8  10.9  8.73 5.88  103.0  13.8 76.1
## 74   74          0=Blood Donor  38   m 43.4  58.9  45.7  45.7   9.2 10.86 5.74   90.0  30.0 73.9
## 75   75          0=Blood Donor  38   m 41.2  43.8  19.9  20.5  10.1  5.95 3.91   63.0  70.8 67.4
## 76   76          0=Blood Donor  38   m 44.7  69.4  47.4  35.1  16.7  6.90 4.14   67.0  17.3 70.1
## 77   77          0=Blood Donor  38   m 42.0  42.7  34.8  42.2   3.3  6.10 4.74   96.0  14.6 66.7
## 78   78          0=Blood Donor  38   m 48.4  44.9  23.4  22.1   7.9 10.53 7.51   87.0  43.2 82.6
## 79   79          0=Blood Donor  38   m 38.3  81.5  65.9  35.3  14.0 11.00 5.46   80.0  45.2 68.1
## 80   80          0=Blood Donor  38   m 40.5  61.7  18.6  24.7   6.7  8.47 6.05   89.0  19.6 75.6
## 81   81          0=Blood Donor  39   m 45.1  63.9  26.0  21.3   9.3  8.57 5.24   79.0  29.4 71.2
## 82   82          0=Blood Donor  39   m 38.8  52.5  54.3  31.3  10.1 10.68 6.26   81.0  31.5 77.2
## 83   83          0=Blood Donor  39   m 47.0  66.5  24.8  29.1  10.5 10.04 6.26   73.0  49.8 78.4
## 84   84          0=Blood Donor  39   m 36.6  71.3  28.9  25.9   6.1  5.70 4.66   77.0  22.6 66.3
## 85   85          0=Blood Donor  39   m 43.9  90.1  87.9  60.6   8.6  9.94 4.64   98.0  99.3 66.2
## 86   86          0=Blood Donor  39   m 43.4  48.6  33.4  35.0  23.4  9.68 5.55   73.0  22.1 75.2
## 87   87          0=Blood Donor  39   m 36.0  36.5  21.5  25.7   3.3  8.43 4.85   93.0  23.1 70.5
## 88   88          0=Blood Donor  39   m 45.7  73.4  45.5  33.8   5.0  9.07 4.41   82.0  20.6 78.9
## 89   89          0=Blood Donor  39   m 37.5  80.2  32.6  25.3   2.7  9.30 6.85   72.0  27.5 73.1
## 90   90          0=Blood Donor  39   m 46.4 102.9  44.4  26.2   4.1  9.29 8.89  103.0  64.0 72.2
## 91   91          0=Blood Donor  39   m 45.8  62.5  20.7  22.8  45.5  8.61 4.78   77.0  15.9 75.5
## 92   92          0=Blood Donor  39   m 46.1  77.1  34.9  37.6   4.1 13.86 8.11   94.0  76.9 71.1
## 93   93          0=Blood Donor  40   m 47.8  68.0  17.5  22.3   7.7  9.94 6.09   88.0  23.3 73.9
## 94   94          0=Blood Donor  40   m 44.5  45.7  25.9  27.6   9.2  8.93 4.49   87.0  17.0 71.2
## 95   95          0=Blood Donor  40   m 41.4  67.5  59.8  36.8   7.3  4.18 6.02   76.0  92.7 72.5
## 96   96          0=Blood Donor  40   m 45.0  74.2  20.9  29.1  12.0  9.10 6.29   92.0  24.1 74.1
## 97   97          0=Blood Donor  40   m 39.1  66.5  33.3  32.9  14.8  7.87 4.91   88.0  18.5 68.8
## 98   98          0=Blood Donor  40   m 45.1  63.4  39.6  31.4  19.7 11.31 4.74   91.0  18.2 81.1
## 99   99          0=Blood Donor  40   m 45.4  52.9  41.3  26.2  10.6 10.27 6.85   82.0  40.2 76.6
## 100 100          0=Blood Donor  40   m 46.9  61.8  27.4  43.0   7.0  7.26 5.09   98.0  14.2 75.3
## 101 101          0=Blood Donor  41   m 45.1  86.8  24.0  23.9  10.6  7.84 6.23   72.0  35.3 75.1
## 102 102          0=Blood Donor  41   m 38.5  63.9  34.3  43.4   9.6  6.80 4.13   90.0  11.4 64.1
## 103 103          0=Blood Donor  41   m 42.3  55.9  19.6  18.9  10.9  7.15 3.29   86.0  24.5 76.1
## 104 104          0=Blood Donor  41   m 46.9  69.0  19.7  27.3   6.1  6.39 4.55   72.0  21.6 71.3
## 105 105          0=Blood Donor  41   m 40.2  48.2  37.0  34.9   9.2 11.35 5.56   78.0  26.6 73.3
## 106 106          0=Blood Donor  41   m 53.3  79.0  29.5  28.5  14.1  7.96 5.90   87.0  33.8 83.4
## 107 107          0=Blood Donor  41   m 44.7  74.9  25.2  20.2   6.3 10.34 4.23   74.0  23.7 72.1
## 108 108          0=Blood Donor  41   m 37.4  75.1  28.0  25.7   4.1 10.62 5.57   83.0  18.6 71.9
## 109 109          0=Blood Donor  42   m 45.3  55.3  31.0  50.0  18.5 15.43 5.88   83.0  15.4 72.4
## 110 110          0=Blood Donor  42   m 44.1  46.8  23.8  19.4   7.0 10.83 6.28   95.0  19.7 73.0
## 111 111          0=Blood Donor  42   m 37.8  78.6  51.4  31.8  10.1  9.66 6.15   85.0  15.1 70.8
## 112 112          0=Blood Donor  42   m 46.3  71.4  30.3  22.5  26.9  7.95 7.30   88.0  21.8 71.8
## 113 113          0=Blood Donor  42   m 46.4  43.7  18.7  24.3   6.3  6.59 4.78   93.0  10.1 73.1
## 114 114          0=Blood Donor  42   m 38.1  88.7  46.7  37.0  12.5  7.26 6.76   54.0  18.4 72.1
## 115 115          0=Blood Donor  42   m 46.9  68.7 118.1  49.3  20.2  7.93 5.62   86.0  74.9 73.8
## 116 116          0=Blood Donor  42   m 37.8  83.7  25.3  20.0  18.6  7.52 5.07  108.0  17.4 64.1
## 117 117          0=Blood Donor  42   m 46.2  57.7  35.6  22.9  14.8 11.01 8.60   80.0  70.1 77.5
## 118 118          0=Blood Donor  43   m 37.0  82.0  25.3  26.2   5.4  8.42 4.96   79.0  15.9 68.4
## 119 119          0=Blood Donor  43   m 39.7 126.0  21.9  28.9  16.2  8.48 5.30  114.0  21.4 80.3
## 120 120          0=Blood Donor  43   m 54.4  99.3  40.2  29.5   6.1  8.84 5.92   95.0  22.3 79.3
## 121 121          0=Blood Donor  43   m 36.3  67.3  28.7  27.9   5.5  8.55 5.27   97.0  17.1 74.2
## 122 122          0=Blood Donor  43   m 48.6  45.0  10.5  40.5   5.3  7.09   NA   63.0  25.1 70.0
## 123 123          0=Blood Donor  43   m 42.9  50.7  26.4  22.0   6.4 10.20 4.72   81.0  15.2 71.8
## 124 124          0=Blood Donor  43   m 39.4  61.8  55.0  32.5   7.1 11.94 7.84   64.0 153.5 75.6
## 125 125          0=Blood Donor  43   m 41.5  75.6  15.3  21.2   5.2  7.36 4.71   84.0  12.9 72.2
## 126 126          0=Blood Donor  43   m 42.8  76.9  57.7  33.0  11.3  9.63 9.43   72.0  23.3 72.9
## 127 127          0=Blood Donor  43   m 43.9  40.7  35.8 188.7   8.7  7.70 5.41   90.0  21.6 75.4
## 128 128          0=Blood Donor  43   m 41.2  59.4  34.3  24.2   4.1  9.64 4.93   84.0  20.8 74.5
## 129 129          0=Blood Donor  44   m 44.4  84.9  28.0  26.1  33.9 10.28 4.68   84.0  14.1 76.9
## 130 130          0=Blood Donor  44   m 38.4 110.8  17.2  30.7   4.6  9.51 5.12   74.0  25.2 73.6
## 131 131          0=Blood Donor  44   m 44.5  93.6  27.5  25.5   5.4  7.79 4.59  108.0  16.7 76.8
## 132 132          0=Blood Donor  44   m 37.4 105.7  16.2  21.3   5.2  8.69 6.02   67.0  14.0 70.9
## 133 133          0=Blood Donor  44   m 35.5  81.7  27.5  29.5   6.4  8.81 6.65   83.0  24.1 68.0
## 134 134          0=Blood Donor  44   m 44.0  84.3  47.4  31.3   4.1 10.28 5.42  105.0  34.2 75.3
## 135 135          0=Blood Donor  44   m 48.6  73.5  49.6  32.5  22.6 11.24 6.68   95.0  32.2 74.0
## 136 136          0=Blood Donor  44   m 40.8  71.6  17.2  21.0   3.5  7.38 4.46   88.0  11.4 63.4
## 137 137          0=Blood Donor  44   m 47.3  43.9  16.2  19.3   4.7 10.02 5.85  100.0  14.9 71.2
## 138 138          0=Blood Donor  44   m 44.6  53.9  28.4  23.8   8.8  9.47 4.87   94.0  21.3 69.2
## 139 139          0=Blood Donor  45   m 41.4  63.2  41.4  31.6   5.8 12.28 7.29   82.0  56.0 70.6
## 140 140          0=Blood Donor  45   m 46.5  77.8  52.9  34.0  12.1  9.82 5.58  101.0  34.9 76.2
## 141 141          0=Blood Donor  45   m 36.2 102.6  70.8  40.3  14.5  8.69 5.98   94.0  80.6 66.6
## 142 142          0=Blood Donor  45   m 41.7  73.2  43.6  29.4   6.4  8.89 5.31   71.0  67.4 70.3
## 143 143          0=Blood Donor  45   m 43.2  68.2  27.8  42.3   6.6 10.93 6.61  105.0  27.2 74.5
## 144 144          0=Blood Donor  45   m 40.3  64.4  18.8  27.2   5.2  6.71 4.25   74.0  19.7 67.2
## 145 145          0=Blood Donor  45   m 46.4  77.0  60.3  32.9   8.8  9.38 6.27   85.0  81.1 75.5
## 146 146          0=Blood Donor  45   m 44.3  71.5  15.9  16.3   7.3  8.00 5.35   83.0  19.8 71.3
## 147 147          0=Blood Donor  45   m 45.7  75.4  41.4  28.6   7.7 10.88 6.25   99.0  85.4 78.8
## 148 148          0=Blood Donor  46   m 42.6  61.6  18.6  21.4  10.2  7.00 6.13   89.0  19.9 73.7
## 149 149          0=Blood Donor  46   m 35.7  49.2  22.7  23.0  17.4  8.51 5.85   87.0  13.4 62.1
## 150 150          0=Blood Donor  46   m 39.7  40.3  14.6  22.3   5.3  6.30 4.66   71.0  11.7 67.2
## 151 151          0=Blood Donor  46   m 37.9  79.9  17.7  20.1  12.7 10.10 5.38   72.0  12.7 67.7
## 152 152          0=Blood Donor  46   m 41.8  65.6  30.5  28.2   6.1 10.68 4.72   82.0  24.8 65.0
## 153 153          0=Blood Donor  46   m 47.7  51.6  19.7  21.8   6.3  7.25 5.19   84.0  20.9 75.2
## 154 154          0=Blood Donor  46   m 44.8  98.0  41.0  30.6   4.0 10.92 7.42   91.0  28.8 79.8
## 155 155          0=Blood Donor  46   m 49.1  60.0  19.5  20.5   3.1  7.81 5.02  102.0  20.8 70.2
## 156 156          0=Blood Donor  46   m 43.0  41.0  15.1  20.7   5.1  7.87 5.35   84.0  15.4 73.2
## 157 157          0=Blood Donor  46   m 45.9  80.1  67.5  36.7   2.9  8.73 4.68  113.0  50.1 68.8
## 158 158          0=Blood Donor  46   m 49.7  48.2  11.5  17.6  11.2  6.74 3.71  106.0  10.6 75.2
## 159 159          0=Blood Donor  46   m 37.3  91.6  33.4  35.9   2.6  9.74 6.73   78.0  64.2 69.9
## 160 160          0=Blood Donor  46   m 47.4  55.9  35.2  33.5  10.2 10.61 4.95   96.0  41.7 76.3
## 161 161          0=Blood Donor  46   m 51.8  82.6  37.3  29.1  13.4  9.97 7.40   90.0  30.1 80.3
## 162 162          0=Blood Donor  47   m 44.7  59.3  27.8  30.5   6.9  7.37 5.10  101.0  21.1 77.2
## 163 163          0=Blood Donor  47   m 41.6  61.0  31.5  25.6   7.3  8.59 5.66   69.0  39.1 72.9
## 164 164          0=Blood Donor  47   m 49.5  75.2  29.6  29.0   7.3 10.67 5.96   75.0  34.9 72.4
## 165 165          0=Blood Donor  47   m 40.8  42.8  39.0  31.7  23.5  6.44 4.86   96.0  27.8 66.4
## 166 166          0=Blood Donor  47   m 48.0  66.5  17.5  23.2   9.9  7.09 5.06   81.0  14.9 68.1
## 167 167          0=Blood Donor  47   m 42.1  81.6  26.4  26.4   5.5 10.50 5.95   97.0  35.3 77.5
## 168 168          0=Blood Donor  47   m 42.2  52.9  20.7  27.1  13.9 10.15 5.15   79.0  28.8 69.5
## 169 169          0=Blood Donor  47   m 48.3  59.3  49.9  31.7   7.1 11.09 5.56   88.0  91.5 73.0
## 170 170          0=Blood Donor  47   m 46.2  63.0   7.0  17.4   6.5  7.06 5.23   60.0  26.6 75.4
## 171 171          0=Blood Donor  47   m 45.3  51.6  18.4  16.9   7.1  8.96 4.29   74.0  15.7 69.1
## 172 172          0=Blood Donor  47   m 36.7  44.8  29.3  23.5   6.9  7.38 4.44   87.0  24.4 68.3
## 173 173          0=Blood Donor  47   m 48.0  56.4  23.0  25.7   6.5  8.32 6.30   89.0  23.3 78.0
## 174 174          0=Blood Donor  47   m 55.4  61.2  25.4  32.9  28.3  8.39 5.25   96.0  10.3 82.1
## 175 175          0=Blood Donor  48   m 42.5  69.2  44.6  28.3  15.8 11.92 6.76   86.0  42.9 81.5
## 176 176          0=Blood Donor  48   m 46.2  59.9  14.6  25.7   5.3  6.93 6.29   66.0  23.4 75.8
## 177 177          0=Blood Donor  48   m 38.2  94.9  32.0  29.4  21.5  7.93 5.36   98.0  53.0 71.8
## 178 178          0=Blood Donor  48   m 43.1  83.9  20.8  27.4  18.3  9.82 6.14   90.0  16.4 74.9
## 179 179          0=Blood Donor  48   m 44.7  56.4  20.9  24.2  17.5  5.49 5.65   74.0  28.5 75.0
## 180 180          0=Blood Donor  48   m 38.8  94.7  28.6  33.4   5.1  7.93 4.27   87.0  14.7 66.8
## 181 181          0=Blood Donor  48   m 43.4  41.2  18.4  21.2   9.8  7.19 6.37   80.0  15.8 68.9
## 182 182          0=Blood Donor  48   m 46.0  58.1  21.4  29.3   6.9  9.36 5.70   83.0  32.3 74.1
## 183 183          0=Blood Donor  48   m 45.7  88.5  59.1  34.0   6.5 10.81 6.25   87.0  38.3 74.1
## 184 184          0=Blood Donor  48   m 42.6  69.1  17.6  28.3   7.7 15.40 5.07   81.0  29.9 77.8
## 185 185          0=Blood Donor  48   m 46.4  64.1  29.3  27.6  13.2 10.07 8.28   98.0  28.9 83.3
## 186 186          0=Blood Donor  48   m 50.4  34.6  37.2  28.0  17.3 10.87 6.97  114.0  45.2 72.9
## 187 187          0=Blood Donor  49   m 39.1  62.1  23.8  19.6   3.5  9.19 4.82   85.0  19.4 69.8
## 188 188          0=Blood Donor  49   m 39.7  77.3  20.2  19.0   8.8  7.26 4.98   84.0  74.5 65.4
## 189 189          0=Blood Donor  49   m 41.2  96.0  25.0  27.7  15.6  7.12 5.61   92.0  37.8 68.7
## 190 190          0=Blood Donor  49   m 44.7  60.2  34.6  28.5   7.1 10.14 5.68   98.0  87.0 69.8
## 191 191          0=Blood Donor  49   m 44.4  63.3  13.5  16.4   7.3 11.19 4.49   73.0  13.6 72.3
## 192 192          0=Blood Donor  49   m 40.2  73.8  17.9  23.6   7.6  7.99 5.31  106.0  15.9 71.4
## 193 193          0=Blood Donor  49   m 44.3  84.1  29.0  29.0  16.2  8.18 4.65   87.0  21.9 70.8
## 194 194          0=Blood Donor  49   m 47.8  67.9  44.2  29.9   6.9  8.76 6.23   99.0  26.9 79.5
## 195 195          0=Blood Donor  50   m 40.0  87.8  87.5  52.6   4.8  8.70 6.46   76.0 152.5 71.0
## 196 196          0=Blood Donor  50   m 46.6  66.3  19.5  23.7  18.5  8.27 5.73   92.0  12.1 76.7
## 197 197          0=Blood Donor  50   m 44.3  82.5  38.6  32.9   7.3  8.57 5.95   83.0  23.4 66.6
## 198 198          0=Blood Donor  50   m 45.7  62.6  55.9  24.3  12.8 10.79 6.42   89.0  55.2 74.2
## 199 199          0=Blood Donor  50   m 43.5  76.2  13.1  18.8   5.6  8.11 4.55   57.0  16.5 67.0
## 200 200          0=Blood Donor  50   m 36.0  51.0  26.1  29.0   6.5  7.50 5.75   67.0  64.0 70.5
## 201 201          0=Blood Donor  50   m 35.5  59.4  43.9  35.8   7.6 11.23 6.56  106.0  24.9 73.2
## 202 202          0=Blood Donor  50   m 40.3  70.5  46.4  32.3   6.8  8.11 4.06   77.0  16.9 69.2
## 203 203          0=Blood Donor  50   m 43.8  56.9  29.5  32.8   4.1  7.77 5.80   72.0  53.6 72.5
## 204 204          0=Blood Donor  50   m 43.1  73.7  19.0  21.8   2.9  9.45 6.06   91.0  33.3 68.9
## 205 205          0=Blood Donor  50   m 39.7  96.5  54.8  30.8   3.3  8.98 5.66   82.0  52.4 65.8
## 206 206          0=Blood Donor  50   m 42.2 145.0  27.5  37.9   4.5 13.71 8.80  103.0 239.0 73.1
## 207 207          0=Blood Donor  51   m 38.0  54.8  23.8  28.6  13.5  6.33 4.65   99.0  18.3 66.4
## 208 208          0=Blood Donor  51   m 36.8  98.5  25.5  27.7   5.0  9.49 6.08   89.0  18.2 64.9
## 209 209          0=Blood Donor  51   m 47.2  78.1  27.4  23.9   8.4 10.14 6.54   86.0  35.3 71.6
## 210 210          0=Blood Donor  51   m 42.6  69.1  17.6  28.3   7.7 15.40 5.07   81.0  29.9 77.8
## 211 211          0=Blood Donor  51   m 42.0  84.3  14.7  19.2   3.2  8.19 4.68   81.0  20.9 77.1
## 212 212          0=Blood Donor  51   m 45.9  66.7  31.8  28.1   9.0 10.08 5.61   85.0  36.2 73.0
## 213 213          0=Blood Donor  51   m 50.8  56.0  33.2  32.9   6.3 11.33 5.93   93.0  22.4 80.3
## 214 214          0=Blood Donor  51   m 46.3  69.4  20.1  26.8   4.5  9.99 4.14   81.0  12.3 73.9
## 215 215          0=Blood Donor  52   m 42.3  72.6  47.4  23.8   6.0  8.62 7.20   86.0  36.1 77.6
## 216 216          0=Blood Donor  52   m 42.2  72.2  47.9  23.7   8.6 11.91 6.29   96.0  62.5 72.9
## 217 217          0=Blood Donor  52   m 82.2  82.2  37.0  23.7   7.8  8.90 6.09   77.0  87.8 67.4
## 218 218          0=Blood Donor  52   m 39.3  63.6  20.7  25.3   4.4  8.26 5.35   84.0  18.9 64.4
## 219 219          0=Blood Donor  52   m 46.8  85.5  15.2  31.9  10.3  9.09 6.56   89.0  21.8 73.3
## 220 220          0=Blood Donor  52   m 44.7  43.5  40.9  47.2  10.4 10.08 5.00   74.0  26.5 75.4
## 221 221          0=Blood Donor  52   m 37.2  73.6  28.9  29.8   6.6  6.80 4.94    8.0  24.1 64.2
## 222 222          0=Blood Donor  52   m 40.7  78.6  43.3  27.1  13.4 10.95 5.22   73.0  30.0 80.9
## 223 223          0=Blood Donor  52   m 41.2  67.4  20.4  18.8   4.3  8.51 4.97   82.0  40.4 68.5
## 224 224          0=Blood Donor  52   m 46.6  72.2  35.0  41.1   4.6  7.70 6.92   80.0  21.5 79.6
## 225 225          0=Blood Donor  52   m 41.0  61.4  28.7  34.8   5.4  9.36 6.66  100.0  26.8 73.6
## 226 226          0=Blood Donor  52   m 41.6  59.1  26.3  25.6   3.0  9.55 4.50   94.0  33.0 71.1
## 227 227          0=Blood Donor  53   m 45.3  53.0  39.6  31.3   9.6  9.96 7.22   73.0  42.9 78.6
## 228 228          0=Blood Donor  53   m 38.7 104.0  66.9  34.3   7.8  8.07 4.60  106.0  73.7 73.2
## 229 229          0=Blood Donor  53   m 44.5  61.2  14.4  18.1   8.0  6.95 5.00   70.0  18.3 72.0
## 230 230          0=Blood Donor  53   m 49.0  86.0  28.9  23.9  11.8  6.09 4.00   74.0  33.6 75.8
## 231 231          0=Blood Donor  53   m 37.8  98.1  30.5  21.1   4.0  5.02 4.42   94.0  23.2 65.2
## 232 232          0=Blood Donor  53   m 44.8 119.7  29.2  20.7   6.0 13.80 8.78   64.0  49.3 75.4
## 233 233          0=Blood Donor  53   m 40.5  76.1  27.8  22.0   6.3 11.14 6.96   90.0  53.1 71.3
## 234 234          0=Blood Donor  53   m 41.7  45.3  23.2  25.1  10.8  5.68 5.78  119.0 114.9 67.9
## 235 235          0=Blood Donor  53   m 38.1  82.5   8.0  17.5   2.4  9.13 6.28  103.0  35.8 69.9
## 236 236          0=Blood Donor  53   m 49.2  71.8  42.8  29.4   6.8 15.10 6.24  107.0  48.3 77.8
## 237 237          0=Blood Donor  54   m 46.9  74.7  36.2  52.6   6.1  8.84 5.20   86.0  33.2 79.3
## 238 238          0=Blood Donor  54   m 46.0  70.2  18.6  24.7  24.1  7.83 6.24   76.0  24.3 76.8
## 239 239          0=Blood Donor  54   m 43.0  67.0  36.1  26.1   5.0 10.20 5.98  105.0  45.4 75.9
## 240 240          0=Blood Donor  54   m 46.4  75.1  54.1  39.6  10.6  6.59 7.43   85.0  73.2 75.2
## 241 241          0=Blood Donor  54   m 40.8  72.0  25.9  29.2   8.5  7.10 5.79   89.0  15.6 67.9
## 242 242          0=Blood Donor  54   m 41.6 100.4  51.8  35.7   4.3 10.37 7.29   92.0  82.6 72.4
## 243 243          0=Blood Donor  55   m 44.1  60.0  26.3  25.9   5.1  7.23 7.30   88.0  41.6 77.7
## 244 244          0=Blood Donor  55   m 39.0  45.8  23.5  21.2   2.4  8.41 7.73   73.0  36.3 73.0
## 245 245          0=Blood Donor  55   m 42.9  92.6  21.6  26.1   7.4 12.86 5.73   94.0  42.9 70.1
## 246 246          0=Blood Donor  55   m 40.0  44.9  10.2  14.1   2.6  5.98 4.55   71.0   8.8 66.3
## 247 247          0=Blood Donor  55   m 46.2  87.1  36.9  21.0   4.5  7.55 6.33   80.0  30.2 72.2
## 248 248          0=Blood Donor  55   m 47.6  71.9  25.8  24.5   5.8  9.24 4.63   83.0  29.1 76.7
## 249 249          0=Blood Donor  55   m 28.1  65.5  16.6  17.5   2.8  5.58 4.39   65.0  26.2 62.4
## 250 250          0=Blood Donor  55   m 44.7  71.6  22.9  22.1   5.5  6.82 4.61  105.0  59.2 72.7
## 251 251          0=Blood Donor  55   m 41.5  59.5  15.4  16.2   6.8  6.35 5.22   80.0  12.4 69.9
## 252 252          0=Blood Donor  56   m 39.9  62.9  27.2  22.8   7.7  5.74 6.75   86.0  30.7 72.5
## 253 253          0=Blood Donor  56   m 39.4  97.9  28.2  24.7   5.9 10.40 6.61   82.0  17.8 74.1
## 254 254          0=Blood Donor  56   m 42.9  50.0  20.4  22.1   5.4  7.28 5.37   90.0  34.6 76.0
## 255 255          0=Blood Donor  56   m 37.9  49.2  16.6  15.7   3.7  9.90 5.30   95.0  20.8 67.1
## 256 256          0=Blood Donor  56   m 42.1  45.6  30.0  26.7   6.1  8.90 6.40   71.0  37.6 70.1
## 257 257          0=Blood Donor  56   m 40.2  37.1  30.1  25.1  10.2  9.69 4.93  103.0  20.7 71.9
## 258 258          0=Blood Donor  56   m 49.5  56.3  22.1  24.9  11.5  8.56 4.69   91.0  14.7 69.6
## 259 259          0=Blood Donor  56   m 45.7  45.3  19.5  27.0   9.3 10.62 6.04   94.0  17.4 74.5
## 260 260          0=Blood Donor  57   m 59.7  64.5  17.3  21.2  18.9 12.07 3.97  106.0  15.1 77.6
## 261 261          0=Blood Donor  57   m 43.5  56.2  60.4  37.3   7.3  6.79 5.99  110.0 185.2 71.8
## 262 262          0=Blood Donor  57   m 43.3  86.8  21.2  22.2   6.8  7.87 4.91   65.0  19.2 71.3
## 263 263          0=Blood Donor  57   m 46.4  80.1  20.2  23.9  19.2  8.02 5.31   74.0  17.1 77.5
## 264 264          0=Blood Donor  58   m 44.0  56.0  30.6  33.0   4.8 12.37 6.33   74.0  58.7 75.8
## 265 265          0=Blood Donor  58   m 46.8  79.3  38.0  24.1   4.7  9.51 5.07   99.0  22.9 72.4
## 266 266          0=Blood Donor  58   m 41.3  58.9  12.8  23.4   5.4  8.17 5.70   60.0  10.8 70.1
## 267 267          0=Blood Donor  58   m 40.9  55.8  17.5  23.0   5.3  8.52 6.41   93.0  18.5 70.9
## 268 268          0=Blood Donor  59   m 45.7 115.4  16.4  23.8   3.7  8.20 4.46   70.0  14.3 78.5
## 269 269          0=Blood Donor  59   m 45.3 106.5  13.5  19.2   6.9  7.97 4.86   67.0  15.7 74.6
## 270 270          0=Blood Donor  59   m 41.9  72.4  19.3  25.5  29.8  5.60 3.09   78.0  27.2 69.0
## 271 271          0=Blood Donor  59   m 39.8  49.4  25.4  21.4  24.7  7.50 3.69   86.0  18.7 71.9
## 272 272          0=Blood Donor  59   m 38.4  61.2  15.9  27.2   3.0  6.88 6.89   91.0  14.0 64.5
## 273 273          0=Blood Donor  59   m 48.9  50.3  23.7  28.1  15.8  8.97 4.33   75.0  19.0 77.6
## 274 274          0=Blood Donor  59   m 43.8  46.6  28.3  27.4   6.1 10.56 5.47   83.0  20.3 78.5
## 275 275          0=Blood Donor  59   m 37.8  83.7  25.3  20.0  18.6  7.52 5.07  108.0  17.4 64.1
## 276 276          0=Blood Donor  60   m 42.2  48.8  41.0  34.8   3.6  9.60 5.60   98.0  71.4 71.6
## 277 277          0=Blood Donor  60   m 46.3  59.7  24.4  30.4  18.0  7.05 6.20   91.0  13.8 66.9
## 278 278          0=Blood Donor  60   m 40.4  46.8  17.7  25.7  13.5  5.79 5.42   92.0  19.2 70.0
## 279 279          0=Blood Donor  60   m 43.4  71.5  10.2  17.4   7.5  8.11 5.31   74.0  13.3 71.5
## 280 280          0=Blood Donor  60   m 41.1  67.2  49.0  34.4  16.4 10.14 4.65  107.0  25.5 71.9
## 281 281          0=Blood Donor  60   m 45.2  89.4  38.6  27.2   8.6  5.19 6.01   75.0  76.9 74.4
## 282 282          0=Blood Donor  61   m 45.9  73.3  17.1  24.3   4.8 10.01 4.95   88.0  23.5 70.8
## 283 283          0=Blood Donor  61   m 43.4  70.1  19.9  24.0   3.6  6.89 4.58   64.0  24.9 74.2
## 284 284          0=Blood Donor  61   m 34.3  60.5  35.4  26.6  15.2  9.03 7.62   74.0  51.4 76.0
## 285 285          0=Blood Donor  61   m 44.8 104.9  15.0  18.8   6.5  9.38 5.42   69.0  26.2 79.6
## 286 286          0=Blood Donor  61   m 38.9  59.5  22.8  30.9   6.3  9.45 5.23   95.0  20.3 71.4
## 287 287          0=Blood Donor  62   m 42.1  51.4  11.8  21.8   2.7  5.70 5.25   80.0  12.9 72.0
## 288 288          0=Blood Donor  62   m 46.6  98.0  36.7  29.4   7.0  7.56 5.52   70.0  23.1 86.5
## 289 289          0=Blood Donor  62   m 39.6  42.7  31.3  30.9  13.5  7.17 3.81   89.0  16.3 64.8
## 290 290          0=Blood Donor  62   m 44.7  76.5  43.7  27.5   6.9  9.94 5.74   83.0  59.3 77.8
## 291 291          0=Blood Donor  63   m 39.5  59.6  26.2  25.4  12.4  6.78 6.18   78.0  22.6 72.7
## 292 292          0=Blood Donor  63   m 45.3  71.3  16.6  24.1   5.7  8.92 4.69   81.0  19.8 73.7
## 293 293          0=Blood Donor  63   m 40.8  74.3  25.0  27.5   5.5  7.74 6.35  107.0  50.4 69.3
## 294 294          0=Blood Donor  64   m 46.0  75.9  34.8  30.6  10.8  9.43 6.69   81.0  53.7 70.7
## 295 295          0=Blood Donor  64   m 40.1  66.7  18.3  22.5   5.7  9.65 6.37   73.0  19.1 66.0
## 296 296          0=Blood Donor  64   m 35.1  72.5  27.2  30.5  20.8  7.99 6.47   91.0  36.2 68.7
## 297 297          0=Blood Donor  64   m 44.5  87.8  15.1  23.2  12.3  9.49 7.70   78.0  20.0 74.3
## 298 298          0=Blood Donor  65   m 41.0  81.8  27.9  23.6   9.1  7.46 5.84   78.0  21.2 68.2
## 299 299          0=Blood Donor  65   m 43.1  64.8  43.1  35.6   9.5  9.60 4.03   78.0  21.9 71.5
## 300 300          0=Blood Donor  65   m 34.8  66.2  51.9  37.5   6.6  8.39 5.91   72.0 112.8 77.0
## 301 301          0=Blood Donor  65   m 44.7  99.4  31.9  30.5  12.2  7.15 6.31   82.0  38.5 75.7
## 302 302          0=Blood Donor  65   m 39.1  45.8  23.1  27.5   6.4  7.00 6.23   73.0  27.1 64.3
## 303 303          0=Blood Donor  65   m 43.6 104.0  32.3  34.2   7.7  8.23 4.69   89.0  20.8 75.5
## 304 304          0=Blood Donor  66   m 48.4  76.0  31.9  29.6  13.8  8.81 4.17  111.0  26.2 76.7
## 305 305          0=Blood Donor  66   m 40.6  79.6  27.0  28.0  10.1 10.88 5.48   76.0  29.8 71.8
## 306 306          0=Blood Donor  66   m 32.6  58.3  20.3  27.3   9.4  9.40 6.80   88.0  24.6 73.1
## 307 307          0=Blood Donor  66   m 41.0  61.4  28.7  34.8   5.4  9.36 6.66  100.0  26.8 73.6
## 308 308          0=Blood Donor  67   m 44.8  72.8  39.4  28.4  23.3  7.84 7.02   97.0  78.3 67.5
## 309 309          0=Blood Donor  67   m 44.4  86.5  25.2  27.3   9.1  8.85 6.43   88.0  77.2 74.8
## 310 310          0=Blood Donor  67   m 38.7  83.8  19.4  25.8   8.7  7.95 5.53  100.0  16.6 70.4
## 311 311          0=Blood Donor  68   m 42.9  71.1  15.0  34.8   9.3  8.39 6.64   89.0  14.5 75.5
## 312 312          0=Blood Donor  68   m 39.3  76.7  19.7  24.6   6.3 10.51 4.15   74.0  28.1 74.2
## 313 313          0=Blood Donor  70   m 27.8  85.7  25.4  38.9   4.2  6.06 3.96   63.0  46.0 56.9
## 314 314          0=Blood Donor  70   m 41.0  63.5  16.9  21.6   5.9  6.03 4.74   83.0  13.5 73.7
## 315 315          0=Blood Donor  71   m 39.0  87.9  26.1  32.1  12.2 10.30 6.31   90.0  99.7 69.8
## 316 316          0=Blood Donor  76   m 29.2  48.9  25.2  27.2   8.3  4.52 2.79  127.0  18.3 58.1
## 317 317          0=Blood Donor  76   m 38.0  97.1  28.6  33.1  14.1  4.83 5.56   90.0 117.6 73.8
## 318 318          0=Blood Donor  77   m 52.2  52.2  12.0  23.5  10.9  5.51 4.41  103.0  25.8 67.2
## 319 319          0=Blood Donor  32   f 39.9  35.2  22.0  29.8   6.3  8.16 4.37   60.0   4.5 72.5
## 320 320          0=Blood Donor  32   f 47.4  52.5  19.1  17.1   4.6 10.19   NA   63.0  23.0 72.2
## 321 321          0=Blood Donor  32   f 41.1  42.8  10.1  14.1  23.2  6.08 3.75   53.0   9.3 68.9
## 322 322          0=Blood Donor  32   f 43.5  66.2   9.2  17.8   5.7  7.14 4.38   71.0  44.6 76.1
## 323 323          0=Blood Donor  33   f 36.0  77.5  14.8  22.0   4.4  8.61 5.26   66.0  13.1 66.1
## 324 324          0=Blood Donor  33   f 36.9  51.7  17.4  22.0   8.3  7.00 5.02   52.0  19.1 72.0
## 325 325          0=Blood Donor  33   f 44.3  74.0  49.7  52.3   8.5  6.49 3.34   73.0  44.7 73.8
## 326 326          0=Blood Donor  33   f 38.1  35.2  11.9  18.3   3.0  6.09 5.22   76.0  15.4 72.0
## 327 327          0=Blood Donor  33   f 41.0  61.1  27.0  28.0   6.0  8.36 4.93   70.0  24.7 70.5
## 328 328          0=Blood Donor  33   f 38.2  54.4  17.3  21.2   7.1  8.67 5.69   68.0  32.1 66.9
## 329 329          0=Blood Donor  33   f 47.6  95.5  18.8  22.2   2.4  7.84 5.57   71.0  16.9 75.0
## 330 330          0=Blood Donor  33   f 42.4 137.2  14.2  13.1   3.4  8.23   NA   48.0  25.7 74.4
## 331 331          0=Blood Donor  33   f 45.9  72.0  37.8  33.5  17.7  7.32 4.25   81.0  21.5 78.3
## 332 332          0=Blood Donor  33   f 35.4  53.5   9.8  17.6   3.8  6.00 4.48   78.0   8.0 71.5
## 333 333          0=Blood Donor  33   f 38.5  82.2  11.9  17.0   7.3  7.23 3.92   50.0   7.0 73.3
## 334 334          0=Blood Donor  33   f 41.2  73.1  14.3  20.8  11.1  7.40 3.22   56.0  11.4 69.9
## 335 335          0=Blood Donor  33   f 40.6  73.7  12.6  16.3   3.1  7.75 6.36   67.0  19.5 71.4
## 336 336          0=Blood Donor  34   f 37.3  36.3  19.9  28.7   3.8  3.90 4.94   86.0   4.9 70.7
## 337 337          0=Blood Donor  34   f 41.9  47.4  20.8  28.5   8.0  7.66 4.61   97.0  11.2 71.9
## 338 338          0=Blood Donor  34   f 36.3  63.2  21.4  20.4   4.6  7.41 5.17   75.0  18.7 64.2
## 339 339          0=Blood Donor  34   f 36.2  70.9  14.3  21.6   3.7  9.82 5.59   65.0  27.4 74.3
## 340 340          0=Blood Donor  34   f 46.5  52.3  30.5  32.3   5.7  9.05 6.28   90.0  18.5 80.6
## 341 341          0=Blood Donor  34   f 45.5  76.9  17.4  18.6   3.2  8.45 5.10   53.0  25.8 79.7
## 342 342          0=Blood Donor  34   f 39.7  39.3  11.2  16.4   8.4  5.27 4.68   61.0  24.3 71.5
## 343 343          0=Blood Donor  35   f 41.0  62.6  27.9  12.0  12.8 10.34 5.90   78.0  22.8 76.1
## 344 344          0=Blood Donor  35   f 40.5  72.4  14.5  17.9   5.8  9.38 4.13   75.0  17.8 69.9
## 345 345          0=Blood Donor  35   f 43.4  62.6  19.2  22.0   3.0 10.03 5.07   64.0  12.4 72.8
## 346 346          0=Blood Donor  35   f 45.6  38.2  22.0  21.9   3.0  6.94 4.69   64.0  17.4 70.4
## 347 347          0=Blood Donor  35   f 62.9  51.2  20.7  23.0   2.9  6.33 4.62   67.0  15.2 71.9
## 348 348          0=Blood Donor  35   f 42.0  69.0  19.9  16.6  10.8  7.85 4.43   67.0  15.1 64.1
## 349 349          0=Blood Donor  35   f 38.0  51.3  18.3  15.3   3.9  8.63 4.91   61.0  16.2 71.8
## 350 350          0=Blood Donor  35   f 46.9  50.8  35.4  22.1  13.1  8.27 5.70   95.0  37.3 80.7
## 351 351          0=Blood Donor  35   f 46.1  88.7  23.1  20.0   7.7  8.41 4.79   74.0  28.1 79.3
## 352 352          0=Blood Donor  35   f 44.7  83.2  25.3  22.6   3.9  8.02 5.73   68.0  10.8 76.4
## 353 353          0=Blood Donor  36   f 46.4  69.1  17.7  24.3   6.6  6.50 5.62   67.0  18.5 75.5
## 354 354          0=Blood Donor  36   f 39.7  52.0  39.9  33.5   2.9  9.00 4.18   77.0  27.0 78.5
## 355 355          0=Blood Donor  36   f 39.9  59.0  11.3  20.4   9.4  7.60 5.51   69.0  16.0 81.0
## 356 356          0=Blood Donor  36   f 42.7  55.1  12.4  16.0   6.8  6.63 5.05   75.0  10.4 72.8
## 357 357          0=Blood Donor  37   f 39.2  58.1  12.0  21.0   5.3  5.96 5.80   72.0  15.6 70.7
## 358 358          0=Blood Donor  37   f 42.1  47.5  18.3  21.7   2.8  8.29 4.36   83.0  28.9 73.4
## 359 359          0=Blood Donor  37   f 40.5  47.3  15.3  19.4   4.9  5.40 3.95   76.0   7.1 69.0
## 360 360          0=Blood Donor  38   f 40.0  73.5  16.6  19.2   8.3  5.23 5.52   54.0  24.0 71.0
## 361 361          0=Blood Donor  38   f 48.5  56.2  36.0  27.9  15.3 11.07 6.06   69.0  23.5 77.3
## 362 362          0=Blood Donor  38   f 50.3  92.1  40.1  30.9   4.2 10.02 3.97  100.0  30.5 77.3
## 363 363          0=Blood Donor  38   f 41.2  61.9  19.4  22.9  10.5  7.86 3.61   85.0  19.5 66.6
## 364 364          0=Blood Donor  38   f 40.3  87.2  21.4  23.9   5.5  7.52 5.73   69.0  20.1 74.0
## 365 365          0=Blood Donor  38   f 40.0  79.3  11.9  22.0   6.5  8.33 4.58   60.0  13.7 68.1
## 366 366          0=Blood Donor  39   f 31.4 106.0  16.6  17.0   2.4  5.95 5.30   68.0  22.9 72.3
## 367 367          0=Blood Donor  39   f 46.4  59.2  14.1  18.9   4.5  7.90 4.55   61.0  14.5 77.3
## 368 368          0=Blood Donor  40   f 41.7  55.3  12.4  23.5   8.2  4.80 5.32   75.0  10.6 73.5
## 369 369          0=Blood Donor  40   f 41.6  60.4  14.7  16.3   5.7  7.61 4.57   72.0   9.8 73.1
## 370 370          0=Blood Donor  40   f 43.2  42.4  15.7  23.6   9.7  7.56 6.74   88.0  11.5 73.2
## 371 371          0=Blood Donor  40   f 42.9  54.7  46.2  32.8  11.8  8.29 5.25  105.0  27.9 73.9
## 372 372          0=Blood Donor  40   f 39.9  50.2  14.9  20.4   5.1  6.49 4.92   68.0  24.1 72.8
## 373 373          0=Blood Donor  41   f 40.4  75.7  24.3  25.2   6.0  8.95 6.01   64.0  15.8 73.0
## 374 374          0=Blood Donor  41   f 42.4  51.3  16.3  18.3   4.0  6.68 4.24   65.0  17.1 71.9
## 375 375          0=Blood Donor  41   f 39.3  67.9  17.6  23.4   3.7  6.57 4.33   71.0  61.0 77.1
## 376 376          0=Blood Donor  41   f 46.2  48.3  15.8  16.6   4.3  4.55 5.18   67.0  13.0 73.7
## 377 377          0=Blood Donor  41   f 39.8  67.9  19.4  19.5  12.2  7.41 5.02   64.0  27.3 65.5
## 378 378          0=Blood Donor  42   f 43.4  54.0  11.3  21.3   1.8  6.43 4.43   54.0  18.6 82.3
## 379 379          0=Blood Donor  42   f 38.7  64.1  35.9  27.8   6.0  8.18 4.87   64.0  15.2 72.1
## 380 380          0=Blood Donor  43   f 37.6  77.1   8.3  15.9  12.5  8.37 4.49   73.0  68.9 67.1
## 381 381          0=Blood Donor  43   f 44.1  41.4  17.6  19.8   7.4  7.52 6.05   69.0  21.3 73.2
## 382 382          0=Blood Donor  43   f 41.2  38.2  18.6  20.5   9.3  6.15 5.44   64.0   9.7 70.9
## 383 383          0=Blood Donor  43   f 39.0  83.1  21.3  18.8   3.5 12.80 9.03   58.0  22.7 73.1
## 384 384          0=Blood Donor  43   f 39.0  63.0   7.3  17.5   6.4  7.01 4.94   73.0  14.6 74.4
## 385 385          0=Blood Donor  43   f 34.7  80.7  27.0  27.9   3.7  7.18 5.55   68.0   9.2 68.2
## 386 386          0=Blood Donor  43   f 44.8  58.8  23.0  30.1   6.6  8.70 6.08   70.0  10.4 72.8
## 387 387          0=Blood Donor  43   f 33.7  57.5  15.1  24.8   6.9  7.91 5.37   71.0  46.0 68.4
## 388 388          0=Blood Donor  43   f 47.8  40.9  12.9  17.2   5.5  4.31 3.96   76.0  10.4 70.7
## 389 389          0=Blood Donor  44   f 37.4  28.9  16.8  25.8   3.1  6.70 4.45   50.0   9.2 66.3
## 390 390          0=Blood Donor  44   f 45.6  57.6  21.0  19.1   3.7 10.36 6.68   74.0  20.8 74.4
## 391 391          0=Blood Donor  44   f 35.5  60.0  13.7  15.0   9.1  6.71 5.29   64.0   7.4 65.2
## 392 392          0=Blood Donor  44   f 44.0  86.1  15.6  26.1   7.6  6.23 4.72   69.0  11.8 70.5
## 393 393          0=Blood Donor  44   f 48.3 103.3  37.2  41.5   7.0  7.49 5.04   62.0  17.8 77.5
## 394 394          0=Blood Donor  44   f 35.8  65.7  21.2  19.2   4.3 10.19 6.13   61.0  19.6 69.4
## 395 395          0=Blood Donor  44   f 43.0  86.5  18.3  25.0   2.2  8.45 5.90   63.0  13.6 72.7
## 396 396          0=Blood Donor  44   f 36.3  76.4  17.1  20.8   4.6  6.80 4.27   74.0  14.3 68.0
## 397 397          0=Blood Donor  44   f 35.5  71.0  15.8  30.0   3.7  7.56 4.43   53.0  17.8 67.7
## 398 398          0=Blood Donor  45   f 36.7  54.9  25.5  25.3   5.7  6.91 5.42   72.0  13.7 67.5
## 399 399          0=Blood Donor  45   f 39.5  92.2  18.7  19.4   3.5  8.32 5.38   85.0  15.8 72.2
## 400 400          0=Blood Donor  45   f 38.6  56.0  20.6  21.5  14.1  6.92 5.48   69.0  14.9 69.9
## 401 401          0=Blood Donor  45   f 41.7  62.4  15.9  16.8   3.7  4.38 5.05   90.0  10.0 70.5
## 402 402          0=Blood Donor  45   f 41.8  87.5  37.1  25.6  10.3 10.25 4.56   86.0  92.3 68.4
## 403 403          0=Blood Donor  45   f 46.4  49.1  14.9  25.5  11.0  8.77 2.86   94.0  12.0 77.1
## 404 404          0=Blood Donor  45   f 37.5  54.3  12.9  14.8   5.9  6.95 5.29   66.0  49.4 70.1
## 405 405          0=Blood Donor  45   f 37.0  78.2  19.9  19.1   4.3  6.60 4.73   64.0  31.8 69.6
## 406 406          0=Blood Donor  45   f 59.8  59.8  13.2  17.4   6.9  5.62 6.42   70.0  12.3 66.6
## 407 407          0=Blood Donor  46   f 48.8  66.3  19.7  23.6   4.3 10.57 5.88   78.0  24.2 72.4
## 408 408          0=Blood Donor  46   f 36.7  62.3  10.8  17.4   3.7  6.17 4.07   67.0  15.1 69.0
## 409 409          0=Blood Donor  46   f 35.8  50.8  18.6  25.2   3.8  8.50 5.85   54.0  10.1 71.5
## 410 410          0=Blood Donor  46   f 39.9  71.3  15.4  29.5   4.6  5.95 6.94   72.0  13.4 69.5
## 411 411          0=Blood Donor  46   f 32.4  56.5  23.8  24.8   6.4  8.22 5.19   64.0  11.0 72.0
## 412 412          0=Blood Donor  46   f 40.1  70.1  15.7  23.8   6.0  8.41 6.03   86.0  11.0 76.4
## 413 413          0=Blood Donor  46   f 39.9  73.9  14.0  17.2  16.3  6.93 5.11   71.0  12.7 64.7
## 414 414          0=Blood Donor  46   f 42.9  55.1  15.2  29.8   3.6  8.37   NA   61.0  29.0 71.9
## 415 415          0=Blood Donor  46   f 41.1  47.5  21.0  17.7   7.1  7.55 4.42   62.0  11.9 69.8
## 416 416          0=Blood Donor  46   f 42.3  61.9  20.0  21.8   9.7  8.80 7.09   67.0  35.0 75.2
## 417 417          0=Blood Donor  46   f 37.9  59.5  33.0  25.0   3.7  6.06 5.30   92.0  43.9 70.0
## 418 418          0=Blood Donor  46   f 36.8 113.2  31.2  24.8   3.8  9.60 4.83   78.0  19.9 72.7
## 419 419          0=Blood Donor  46   f 51.3  84.1  40.6  43.6   9.2  7.10 5.62   62.0  74.9 77.1
## 420 420          0=Blood Donor  47   f 35.6  37.5  17.6  18.0   4.7  4.32 5.59   75.0  13.0 66.0
## 421 421          0=Blood Donor  47   f 38.7  43.4  12.1  19.4   3.0  5.35 4.60   56.0  15.7 67.8
## 422 422          0=Blood Donor  47   f 36.4  42.0  11.1  18.3   7.2  4.97 5.47   74.0   7.9 67.0
## 423 423          0=Blood Donor  47   f 34.6  54.1  10.2  15.3   8.4  6.50 5.10   76.0  10.6 67.7
## 424 424          0=Blood Donor  47   f 40.3  65.0  13.5  15.2   6.4  7.16 4.55   70.0  16.5 66.2
## 425 425          0=Blood Donor  48   f 45.6 107.2  24.4  39.0  13.8  9.77   NA   88.0  38.0 75.1
## 426 426          0=Blood Donor  48   f 35.2  45.4  23.4  27.1   4.9  6.83 4.35   70.0  11.8 72.1
## 427 427          0=Blood Donor  48   f 39.2  51.0  15.3  18.4   7.6  9.17 6.66   70.0  16.2 71.7
## 428 428          0=Blood Donor  48   f 32.0  66.3  14.2  21.3   5.5  4.72 5.23   41.0  17.2 65.6
## 429 429          0=Blood Donor  48   f 46.3  71.8  23.0  25.2  11.1  9.41 5.84   85.0  19.1 77.4
## 430 430          0=Blood Donor  48   f 45.3  40.6  18.5  27.7   5.7  7.48 4.64   66.0  19.6 70.6
## 431 431          0=Blood Donor  48   f 37.5  88.3  14.7  19.6   5.4  9.28 4.68   61.0  12.3 67.9
## 432 432          0=Blood Donor  48   f 39.6  65.9  64.3  39.5   2.8  8.80 6.14   77.0  24.1 75.8
## 433 433          0=Blood Donor  48   f 43.7  50.1  17.3  26.3   8.1  8.15 5.38   64.0  13.4 73.1
## 434 434          0=Blood Donor  48   f 46.8  93.3  10.0  23.2   4.3 12.41   NA   52.0  23.9 72.4
## 435 435          0=Blood Donor  48   f 42.5  62.2  12.1  20.1  23.1  4.01 5.58   67.0  13.0 74.2
## 436 436          0=Blood Donor  48   f 44.4  52.5  16.4  23.4   4.5  9.06 6.78   74.0  10.3 73.1
## 437 437          0=Blood Donor  48   f 44.4  64.5  17.2  21.1  17.3  4.93 4.05   67.0  12.1 71.2
## 438 438          0=Blood Donor  48   f 38.8  43.9  12.8  13.3   8.6  5.63 5.31   66.0  21.4 63.2
## 439 439          0=Blood Donor  49   f 38.8 120.2  25.2  21.5  12.0  8.29 7.11   52.0  18.6 70.7
## 440 440          0=Blood Donor  49   f 40.9  58.4  20.1  26.5   2.6  9.77 5.99   53.0  12.7 73.9
## 441 441          0=Blood Donor  49   f 39.1  89.4  15.4  24.1   4.1 10.03 8.36   74.0  12.0 68.1
## 442 442          0=Blood Donor  49   f 39.3  59.4  18.3  15.0   4.8  8.03 4.58   83.0  12.5 74.3
## 443 443          0=Blood Donor  49   f 40.5  31.3  16.2  19.4  11.2  4.95 5.10   75.0  14.9 73.2
## 444 444          0=Blood Donor  49   f 34.9  37.9  15.3  19.4   7.1  5.30 5.88   83.0   7.9 62.5
## 445 445          0=Blood Donor  49   f 45.4  45.9  14.3  15.9   5.8  9.05 6.81   69.0  14.5 78.2
## 446 446          0=Blood Donor  49   f 43.3  71.5  28.4  26.0   6.2  7.68 5.91   77.0  19.1 76.9
## 447 447          0=Blood Donor  50   f 36.9  50.6  15.5  21.7   2.1  9.97 7.01   68.0  17.6 68.4
## 448 448          0=Blood Donor  50   f 47.6  77.2  24.0  17.5   4.8  9.27 6.41   77.0  21.3 73.5
## 449 449          0=Blood Donor  50   f 42.5  74.0  10.9  23.0   4.6  9.42 6.33   76.0   9.0 68.8
## 450 450          0=Blood Donor  50   f 39.9  80.5  24.2  22.8   5.2  9.25 7.41   84.0  19.4 71.2
## 451 451          0=Blood Donor  50   f 41.2  45.6  25.0  25.1   4.1  7.16 6.54   64.0  15.4 68.2
## 452 452          0=Blood Donor  50   f 34.6  63.0  24.7  31.0  12.8  6.55 5.95   70.0  25.4 70.2
## 453 453          0=Blood Donor  51   f 46.3  70.5  75.2  69.2   6.1  7.68 4.73   69.0  52.2 78.3
## 454 454          0=Blood Donor  51   f 37.8  80.7  32.9  27.3   6.2  7.29 5.26   68.0  27.1 70.6
## 455 455          0=Blood Donor  51   f 38.3  52.9  12.4  16.5   3.8  7.22 5.43   55.0  12.7 70.2
## 456 456          0=Blood Donor  51   f 39.6  63.5  17.0  25.9   7.3  7.00 6.97   72.0  10.4 71.9
## 457 457          0=Blood Donor  51   f 38.3  67.7  17.4  19.9   5.4  7.50 4.94   72.0   7.9 69.0
## 458 458          0=Blood Donor  51   f 43.1  52.2  18.5  24.1   8.1  7.52 6.76   60.0  17.4 71.9
## 459 459          0=Blood Donor  51   f 41.4 136.9  33.2  20.0   5.0 10.27 6.24   77.0 106.7 72.2
## 460 460          0=Blood Donor  51   f 41.0  81.2  35.1  33.3   5.2  8.90 6.56   70.0  21.7 72.4
## 461 461          0=Blood Donor  51   f 46.0  71.0  18.1  23.8  59.1  5.99 3.25   82.0  11.4 73.3
## 462 462          0=Blood Donor  51   f 39.6  43.0  16.3  19.6   7.5  5.57 4.96   83.0  62.1 72.9
## 463 463          0=Blood Donor  51   f 47.4 117.3  62.1  30.4   3.8 10.43 6.59   86.0  69.3 71.0
## 464 464          0=Blood Donor  51   f 43.7  61.3  18.0  23.3   4.3  9.57 6.04   70.0  18.6 75.2
## 465 465          0=Blood Donor  52   f 45.5  78.2  25.2  27.7   4.7  8.65 6.04   65.0  28.3 70.5
## 466 466          0=Blood Donor  52   f 43.8  52.0  15.5  23.9   6.0  7.93 5.41   69.0  11.9 72.4
## 467 467          0=Blood Donor  52   f 36.0  47.2  19.6  22.5   5.9  7.85 5.69   85.0  30.4 69.2
## 468 468          0=Blood Donor  52   f 41.7  58.3  22.9  26.7  11.4  9.17 4.33   75.0  14.5 77.1
## 469 469          0=Blood Donor  52   f 40.2  89.7  26.8  19.1   6.9  9.10 7.04   75.0  41.6 67.4
## 470 470          0=Blood Donor  52   f 51.5  81.8  26.3  20.6   7.8  6.74 5.90   88.0  16.3 82.2
## 471 471          0=Blood Donor  52   f 36.7  87.6  34.3  30.8  17.7 10.12 6.98   72.0  24.2 66.3
## 472 472          0=Blood Donor  52   f 41.3  77.4  16.6  22.2   5.0  7.57 7.80   66.0  10.8 70.0
## 473 473          0=Blood Donor  52   f 38.2  70.3  19.5  17.5   2.7 10.02 6.17   65.0  35.5 71.1
## 474 474          0=Blood Donor  53   f 42.4  55.0  20.9  42.4   7.7  6.60 4.26   67.0  14.2 70.9
## 475 475          0=Blood Donor  53   f 39.0  76.0  25.9  20.7   2.8 11.11 6.38   66.0  50.1 70.8
## 476 476          0=Blood Donor  53   f 40.1  84.6  23.0  22.1   7.1  8.40 5.16   70.0  82.6 74.6
## 477 477          0=Blood Donor  53   f 43.7  84.3  18.8  18.6   8.5 10.22 6.65   56.0  16.5 76.9
## 478 478          0=Blood Donor  53   f 43.5  61.7  16.9  20.3   7.0  7.19 6.97   74.0  12.3 69.2
## 479 479          0=Blood Donor  53   f 41.1  91.7  13.8  19.6   3.4  7.87 5.48   72.0  77.3 77.3
## 480 480          0=Blood Donor  53   f 38.0  84.7  23.5  19.8  10.8  7.30 4.82   62.0  11.4 68.5
## 481 481          0=Blood Donor  53   f 47.4  66.9  24.3  32.6  14.9 10.51 6.03   81.0  25.2 75.0
## 482 482          0=Blood Donor  53   f 51.3  84.1  40.6  43.6   9.2  7.10 5.62   62.0  74.9 77.1
## 483 483          0=Blood Donor  54   f 39.9  30.7  17.0  19.3   6.3  6.99 4.95   68.0  13.3 70.7
## 484 484          0=Blood Donor  54   f 26.2  72.9  28.5  28.8   5.5  7.49 4.91   58.0  27.6 57.0
## 485 485          0=Blood Donor  54   f 44.5  53.4  13.4  17.5   5.4  7.74 5.55   66.0  15.4 71.9
## 486 486          0=Blood Donor  54   f 39.9  61.2  23.3  24.5   4.5  9.22 5.47   69.0  58.2 65.8
## 487 487          0=Blood Donor  54   f 43.3  76.5  19.9  22.4   7.0  8.04 6.77   67.0  17.7 73.3
## 488 488          0=Blood Donor  55   f 41.9  86.1  19.3  22.3   7.0  8.21 5.05   71.0  32.5 75.2
## 489 489          0=Blood Donor  55   f 36.2 101.3  19.2  21.9   4.9  6.50 5.86   66.0  12.3 70.3
## 490 490          0=Blood Donor  55   f 35.2  69.6  23.6  26.0   3.8  4.97 4.43   69.0  29.4 60.5
## 491 491          0=Blood Donor  55   f 39.9  83.6  18.4  27.4   8.0  8.43 7.67   73.0  13.6 73.3
## 492 492          0=Blood Donor  56   f 39.7  66.0  14.2  20.8   3.5  7.48 5.88   66.0   7.2 67.2
## 493 493          0=Blood Donor  56   f 39.5  86.9  22.5  22.2   4.7  9.40 6.02   66.0  13.0 72.6
## 494 494          0=Blood Donor  56   f 34.7  90.3  22.7  21.6   3.5  8.07 5.45   67.0   9.0 69.4
## 495 495          0=Blood Donor  56   f 36.6 102.3  13.5  14.9   8.4  6.94 5.50   65.0  16.2 71.0
## 496 496          0=Blood Donor  56   f 33.2  54.3  15.5  22.8   8.0  5.61 3.87   55.0  19.1 63.1
## 497 497          0=Blood Donor  56   f 45.1  79.1  39.0  30.5   5.2  6.47 5.10   64.0 145.3 66.7
## 498 498          0=Blood Donor  56   f 39.9  83.8  19.1  23.6   4.3  7.61 6.06   72.0  16.4 67.1
## 499 499          0=Blood Donor  57   f 48.4  94.4   2.5  39.6   2.3  8.84   NA   82.0   6.4 76.8
## 500 500          0=Blood Donor  57   f 41.2  83.5  32.6  39.3   4.0 10.67 8.46   69.0  22.4 75.7
## 501 501          0=Blood Donor  57   f 42.6  57.1  15.0  18.9   5.3  8.90 5.93   61.0  21.3 74.8
## 502 502          0=Blood Donor  57   f 38.6  80.9  33.1  26.7   6.5  6.45 5.10   59.0  11.3 70.9
## 503 503          0=Blood Donor  57   f 27.3  85.1  18.4  25.4   2.2  8.96 6.66   68.0  10.2 62.5
## 504 504          0=Blood Donor  57   f 37.9  50.3  12.2  18.1   3.5  6.72 5.06   71.0  10.0 69.3
## 505 505          0=Blood Donor  57   f 38.7  62.8  21.8  29.2   9.2  6.55 7.08   68.0  13.0 70.7
## 506 506          0=Blood Donor  57   f 48.0  56.9   8.6  20.1   4.4  8.14 6.90   63.0  14.8 73.1
## 507 507          0=Blood Donor  57   f 44.7  60.6  16.5  24.3   4.2 10.47 4.90   68.0  15.9 68.5
## 508 508          0=Blood Donor  57   f 42.7  62.9  11.2  16.6  11.6 12.70 6.25   62.0   8.1 71.9
## 509 509          0=Blood Donor  58   f 35.3  91.4  14.7  21.0  18.0  6.58 5.51   60.0  10.2 70.4
## 510 510          0=Blood Donor  58   f 26.3  52.5  39.5  77.2   5.8  5.15 3.53   40.0  31.2 51.0
## 511 511          0=Blood Donor  58   f 47.0  74.8  36.1  28.9   5.3  9.82 6.71   70.0  32.0 76.6
## 512 512          0=Blood Donor  59   f 43.0  82.4  33.1  30.0   7.5  9.20 7.43   61.0  30.7 75.4
## 513 513          0=Blood Donor  59   f 45.1  78.0  26.0  32.4   9.0  9.85 7.32   70.0  12.9 70.9
## 514 514          0=Blood Donor  59   f 40.0  68.4  13.2  20.3   8.2  9.10 6.38   63.0  16.3 71.9
## 515 515          0=Blood Donor  60   f 40.5  86.0  26.0  27.6   5.7  8.60 4.90   58.0  20.1 71.7
## 516 516          0=Blood Donor  60   f 35.8  75.5  28.7  21.5   2.0  9.05 4.56   70.0  24.0 71.8
## 517 517          0=Blood Donor  60   f 52.4  88.2  50.2  31.7   8.8  8.49 5.00   77.0  47.0 77.0
## 518 518          0=Blood Donor  60   f 40.1  80.7  34.6  31.2  11.9  9.32 6.94   68.0  27.4 76.6
## 519 519          0=Blood Donor  60   f 45.4  51.4  16.4  19.0   6.8 10.78 6.79   78.0  12.5 72.8
## 520 520          0=Blood Donor  60   f 41.4  85.1  15.6  18.6  10.0  8.31 5.34  103.0  13.0 71.5
## 521 521          0=Blood Donor  61   f 38.1  66.4  11.8  22.7   6.8  6.35 6.55   65.0  14.5 78.9
## 522 522          0=Blood Donor  61   f 43.4  47.5  12.8  17.3   5.6  7.52 5.81   71.0  11.8 69.9
## 523 523          0=Blood Donor  62   f 36.6  82.5  18.2  24.3  10.6  9.82 7.12   54.0  15.6 67.8
## 524 524          0=Blood Donor  62   f 35.4  59.7  21.2  24.7   3.3  9.00 7.45   59.0  17.7 65.4
## 525 525          0=Blood Donor  62   f 44.0  46.6  24.8  25.5   7.6  6.75 4.59   91.0  39.5 74.3
## 526 526          0=Blood Donor  63   f 47.6  59.9  21.1  27.8   8.4  9.24 6.08   62.0  18.3 74.5
## 527 527          0=Blood Donor  63   f 36.1  67.6  13.8  12.2   5.8  9.44 6.88   66.0  22.4 65.0
## 528 528          0=Blood Donor  63   f 27.8  85.7  25.4  38.9   4.2  6.06 3.96   63.0  46.0 56.9
## 529 529          0=Blood Donor  64   f 39.8  68.1  20.5  24.8   5.8  7.53 7.58   56.0  14.2 65.8
## 530 530          0=Blood Donor  64   f 43.0  52.7  31.6  29.2   5.5 11.69 6.00   63.0  61.9 73.4
## 531 531          0=Blood Donor  65   f 33.0  74.3  13.2  16.8   4.1  7.46 5.76   52.0   9.1 64.2
## 532 532          0=Blood Donor  68   f 41.4 102.3  38.4  26.4   6.8  8.50 6.79   59.0  23.8 68.9
## 533 533          0=Blood Donor  70   f 40.0  97.9  15.1  15.9   6.8 11.46 5.08   62.0  19.2 65.3
## 534 534 0s=suspect Blood Donor  47   m 22.5 124.0  79.5  46.7   2.3  6.83 4.30  170.0 345.6 58.6
## 535 535 0s=suspect Blood Donor  48   m 24.9 116.9  49.2  24.3   4.9  3.44 5.25   29.0  83.0 47.8
## 536 536 0s=suspect Blood Donor  49   m 21.6  42.2   9.5  10.6   2.4  3.75 3.01   64.0  38.9 44.8
## 537 537 0s=suspect Blood Donor  55   m 47.3 106.0 208.8 130.6   0.8 14.80 8.08   76.0  71.6 78.3
## 538 538 0s=suspect Blood Donor  71   m 14.9  69.8  19.7  95.2   9.8 13.30 2.61    9.0   7.6 47.0
## 539 539 0s=suspect Blood Donor  74   m 20.3  84.0  22.8  43.0   5.7  4.91 3.19   52.0 218.3 47.8
## 540 540 0s=suspect Blood Donor  59   f 19.3 208.2 325.3 146.6   6.9  5.33 4.72   32.0 295.6 53.1
## 541 541            1=Hepatitis  38   m 45.0  56.3    NA  33.1   7.0  9.58 6.00   77.9  18.9 63.0
## 542 542            1=Hepatitis  19   m 41.0    NA  87.0  67.0  12.0  7.55 3.90   62.0  65.0 75.0
## 543 543            1=Hepatitis  23   m 47.0  19.1  38.9 164.2  17.0  7.09 3.20   79.3  90.4 70.1
## 544 544            1=Hepatitis  25   m 42.0  38.2  63.3 187.7  14.0  6.00 4.28   66.9  40.2 70.5
## 545 545            1=Hepatitis  27   m 45.0  27.5  10.5  37.8  10.0  8.77 3.20   55.2  35.9 74.5
## 546 546            1=Hepatitis  29   m 49.0    NA  53.0  39.0  15.0  8.79 3.60   79.0  37.0 90.0
## 547 547            1=Hepatitis  30   m 45.0    NA  66.0  45.0  14.0 12.16 6.10   86.0  43.0 77.0
## 548 548            1=Hepatitis  32   m 45.0  34.6  44.3  96.2  16.0 10.11 6.28   81.2  48.1 82.1
## 549 549            1=Hepatitis  32   m 41.0  34.4  12.1  60.9   6.0 13.80 5.48   45.4  33.1 71.1
## 550 550            1=Hepatitis  34   m 46.0  36.7   7.4  31.6   9.0  9.71 5.37   82.3  34.4 71.6
## 551 551            1=Hepatitis  35   m 47.0  37.9  13.3  48.4   8.0 10.30 4.14   69.2  68.2 76.0
## 552 552            1=Hepatitis  36   m 44.0  32.9   9.4  32.0  14.0 11.42 5.73   68.6  40.6 70.9
## 553 553            1=Hepatitis  38   m 41.0  20.6  15.2  53.5  24.0 10.23 4.89   81.8  57.9 71.1
## 554 554            1=Hepatitis  41   m 42.0  39.6  26.5  77.6  42.0  9.67 9.67   57.7 143.4 75.8
## 555 555            1=Hepatitis  44   m 49.0  27.3  40.2  31.1  13.0  8.91 4.07   81.5  27.6 72.8
## 556 556            1=Hepatitis  46   m 48.0  59.5  11.6  39.0   7.0 16.41 4.65   66.4 158.2 72.7
## 557 557            1=Hepatitis  50   m 42.0  41.6  10.2  38.1  17.0  9.54 7.04   75.3  92.1 72.3
## 558 558            1=Hepatitis  51   m 43.0  37.2  21.4 132.8   5.0 10.12 5.23   76.2  76.4 76.7
## 559 559            1=Hepatitis  56   m 37.0 114.0  27.8 324.0  67.0  5.75 3.09   97.7 392.2 77.3
## 560 560            1=Hepatitis  58   m 43.0  99.1  12.2  63.2  13.0  5.95 6.15  147.3 491.0 65.6
## 561 561            1=Hepatitis  33   f 43.0  29.6   3.8  16.7   6.0  6.88 5.72   58.8  11.5 78.2
## 562 562            1=Hepatitis  41   f 37.0  31.2   8.2  38.3   7.0  7.08 5.30   60.8  24.7 82.4
## 563 563            1=Hepatitis  50   f 40.0  32.7   9.0  46.0  10.0  7.51 4.67   56.6  22.3 70.1
## 564 564            1=Hepatitis  61   f 50.0  34.4  27.4 114.4  22.0  9.48 4.62   61.9 169.8 86.0
## 565 565             2=Fibrosis  29   m 41.0  43.1   2.4  83.5   6.0 11.49 5.42   55.2 130.0 66.5
## 566 566             2=Fibrosis  40   m 39.0  43.1  23.8 114.7  11.0  9.64 4.20   70.9 127.3 81.3
## 567 567             2=Fibrosis  46   m 45.0  26.9  23.1 125.0  17.0  6.97 4.01   60.5  72.2 73.0
## 568 568             2=Fibrosis  48   m 49.0  45.2  19.3  69.1  30.0  7.76 4.22   76.7  28.4 72.3
## 569 569             2=Fibrosis  49   m 39.0    NA 118.0  62.0  10.0  7.28 3.50   72.0  74.0 81.0
## 570 570             2=Fibrosis  49   m 46.0    NA 114.0  75.0  16.0 10.43 5.20   72.0  59.0 82.0
## 571 571             2=Fibrosis  50   m 42.0    NA 258.0 106.0  15.0  8.74 4.70   77.0  80.0 84.0
## 572 572             2=Fibrosis  53   m 46.0    NA  34.0  43.0  14.0  8.77 4.00  112.0 203.0 76.0
## 573 573             2=Fibrosis  54   m 41.0  41.8  41.5 187.9  21.0  8.59 5.85   91.0 104.9 79.1
## 574 574             2=Fibrosis  57   m 47.0  29.7  10.2  55.9  12.0  6.60 4.64   70.9  69.6 80.9
## 575 575             2=Fibrosis  59   m 44.0  34.5   8.9  74.5   6.0  9.45 4.45   65.0  95.3 69.7
## 576 576             2=Fibrosis  64   m 38.0  35.7   7.1  41.3  13.0  7.10 4.52   70.0  53.0 66.8
## 577 577             2=Fibrosis  71   m 37.0    NA 130.0  90.0  15.0  9.92 4.70   79.0  77.0 76.0
## 578 578             2=Fibrosis  36   f 46.0  39.3  67.1 161.9  13.0  9.24 4.81   65.3  60.0 73.9
## 579 579             2=Fibrosis  38   f 40.0  39.8  14.9  68.9  11.0  8.55 4.31   60.5  40.1 76.5
## 580 580             2=Fibrosis  57   f 43.0  52.1   8.3  35.8  18.0  8.61 6.19   71.4  27.9 82.0
## 581 581             2=Fibrosis  68   f 43.0  22.9   5.0  42.1  12.0  7.29 4.89   80.9  11.9 76.1
## 582 582             2=Fibrosis  49   f 39.0    NA  46.0  39.0   9.0 10.21 3.10   89.0  53.0 79.0
## 583 583             2=Fibrosis  51   f 37.0    NA 164.0  70.0   9.0  3.99 4.20   67.0  43.0 72.0
## 584 584             2=Fibrosis  56   f 39.0    NA  42.0  34.0  10.0  7.75 5.00   80.0  84.0 78.0
## 585 585             2=Fibrosis  75   f 36.0    NA 114.0 125.0  14.0  6.65   NA   57.0 177.0 72.0
## 586 586            3=Cirrhosis  38   m 44.0    NA  94.0  60.0  12.0  4.37 3.20   61.0  99.0 77.0
## 587 587            3=Cirrhosis  39   m 34.0 137.8   4.8  35.6   9.0  3.65 4.82  519.0 133.4 57.5
## 588 588            3=Cirrhosis  41   m 31.0  85.3   4.8  60.2 200.0  1.80 5.34  106.4 151.0 71.8
## 589 589            3=Cirrhosis  42   m 36.0  69.6  14.9 263.1  40.0  3.61 3.93   49.6  61.0 68.6
## 590 590            3=Cirrhosis  45   m 29.0  11.3   7.1 101.9  31.0  1.73 3.71   76.7  65.6 70.0
## 591 591            3=Cirrhosis  46   m 20.0    NA  62.0 113.0 254.0  1.48   NA  114.0 138.0   NA
## 592 592            3=Cirrhosis  46   m 35.0 109.6   2.3  19.2  11.0  7.10 4.10 1079.1 105.6 69.1
## 593 593            3=Cirrhosis  47   m 42.0    NA 159.0 102.0  11.0  6.29 5.50   58.0 201.0 79.0
## 594 594            3=Cirrhosis  51   m 39.0  66.0  29.6 185.0  19.0  2.00 3.60   58.3 399.5 79.4
## 595 595            3=Cirrhosis  51   m 33.0  29.6   4.5  66.6  91.0  4.02 4.08   75.9  28.5 62.3
## 596 596            3=Cirrhosis  56   m 27.0  81.1  17.0 319.8  37.0  1.42 3.54   66.9  93.7 65.3
## 597 597            3=Cirrhosis  56   m 23.0 105.6   5.1 123.0  43.0  1.80 2.40   62.7  35.9 62.8
## 598 598            3=Cirrhosis  56   m 30.0  40.4   0.9  80.3 119.0  1.88 1.43   79.3  17.6 54.2
## 599 599            3=Cirrhosis  58   m 31.0 143.1   7.0 181.8  58.0  3.29 3.92   66.4 273.7 78.1
## 600 600            3=Cirrhosis  59   m 36.0  49.7   5.2 110.1  37.0  2.29 3.68  118.2  56.9 74.8
## 601 601            3=Cirrhosis  59   m 27.0  73.8   4.0  65.2 209.0  2.47 3.61   71.7  28.5 60.6
## 602 602            3=Cirrhosis  59   m 31.0  86.3   5.4  95.4 117.0  1.57 3.51   60.5  53.6 68.5
## 603 603            3=Cirrhosis  61   m 39.0 102.9  27.3 143.2  15.0  5.38 4.88   72.3 400.3 73.4
## 604 604            3=Cirrhosis  65   m   NA    NA  40.0  54.0  13.0  7.50   NA   70.0 107.0 79.0
## 605 605            3=Cirrhosis  74   m 23.0  34.1   2.1  90.4  22.0  2.50 3.29   51.0  46.8 57.1
## 606 606            3=Cirrhosis  42   f 33.0  79.0   3.7  55.7 200.0  1.72 5.16   89.1 146.3 69.9
## 607 607            3=Cirrhosis  49   f 33.0 190.7   1.2  36.3   7.0  6.92 3.82  485.9 112.0 58.5
## 608 608            3=Cirrhosis  52   f 39.0  37.0   1.3  30.4  21.0  6.33 3.78  158.2 142.5 82.7
## 609 609            3=Cirrhosis  58   f 34.0  46.4  15.0 150.0   8.0  6.26 3.98   56.0  49.7 80.6
## 610 610            3=Cirrhosis  59   f 39.0  51.3  19.6 285.8  40.0  5.77 4.51  136.1 101.1 70.5
## 611 611            3=Cirrhosis  62   f 32.0 416.6   5.9 110.3  50.0  5.57 6.30   55.7 650.9 68.5
## 612 612            3=Cirrhosis  64   f 24.0 102.8   2.9  44.4  20.0  1.54 3.02   63.0  35.9 71.3
## 613 613            3=Cirrhosis  64   f 29.0  87.3   3.5  99.0  48.0  1.66 3.63   66.7  64.2 82.0
## 614 614            3=Cirrhosis  46   f 33.0    NA  39.0  62.0  20.0  3.56 4.20   52.0  50.0 71.0
## 615 615            3=Cirrhosis  59   f 36.0    NA 100.0  80.0  12.0  9.07 5.30   67.0  34.0 68.0
summary(hcvdat)
##        X           Category              Age            Sex           
##  Min.   :  1.0   Length:615         Min.   :19.00   Length:615        
##  1st Qu.:154.5   Class :character   1st Qu.:39.00   Class :character  
##  Median :308.0   Mode  :character   Median :47.00   Mode  :character  
##  Mean   :308.0                      Mean   :47.41                     
##  3rd Qu.:461.5                      3rd Qu.:54.00                     
##  Max.   :615.0                      Max.   :77.00                     
##                                                                       
##       ALB             ALP              ALT              AST        
##  Min.   :14.90   Min.   : 11.30   Min.   :  0.90   Min.   : 10.60  
##  1st Qu.:38.80   1st Qu.: 52.50   1st Qu.: 16.40   1st Qu.: 21.60  
##  Median :41.95   Median : 66.20   Median : 23.00   Median : 25.90  
##  Mean   :41.62   Mean   : 68.28   Mean   : 28.45   Mean   : 34.79  
##  3rd Qu.:45.20   3rd Qu.: 80.10   3rd Qu.: 33.08   3rd Qu.: 32.90  
##  Max.   :82.20   Max.   :416.60   Max.   :325.30   Max.   :324.00  
##  NA's   :1       NA's   :18       NA's   :1                        
##       BIL             CHE              CHOL            CREA        
##  Min.   :  0.8   Min.   : 1.420   Min.   :1.430   Min.   :   8.00  
##  1st Qu.:  5.3   1st Qu.: 6.935   1st Qu.:4.610   1st Qu.:  67.00  
##  Median :  7.3   Median : 8.260   Median :5.300   Median :  77.00  
##  Mean   : 11.4   Mean   : 8.197   Mean   :5.368   Mean   :  81.29  
##  3rd Qu.: 11.2   3rd Qu.: 9.590   3rd Qu.:6.060   3rd Qu.:  88.00  
##  Max.   :254.0   Max.   :16.410   Max.   :9.670   Max.   :1079.10  
##                                   NA's   :10                       
##       GGT              PROT      
##  Min.   :  4.50   Min.   :44.80  
##  1st Qu.: 15.70   1st Qu.:69.30  
##  Median : 23.30   Median :72.20  
##  Mean   : 39.53   Mean   :72.04  
##  3rd Qu.: 40.20   3rd Qu.:75.40  
##  Max.   :650.90   Max.   :90.00  
##                   NA's   :1

Las variables disponibles son:

  • Category: Distingue donantes sanos de personas afectadas y los grados de afectación. Categórica. 5 valores diferentes.
  • Age: Edad del paciente. Numérica.
  • Sex: Sexo del paciente. Categórica. 2 valores diferentes.
  • ALB: Nivel de albúmina en sangre. Numérica.
  • ALP: Nivel de fosfatasa alcalina en sangre. Numérica.
  • ALT: Nivel de transaminasa alcalina en sangre. Numérica.
  • AST: Nivel de aspartato de aminotransferasa en sangre. Numérica.
  • BIL: Nivel de bilirrubina en sangre. Numérica.
  • CHE: Nivel de colinesterasa en sangre. Numérica.
  • CHOL: Nivel de colesterol en sangre. Numérica.
  • CREA: Nivel de creatinina en sangre. Numérica.
  • GGT: Nivel de gamma glutamil transferasa en sangre. Numérica.
  • PROT: Nivel de proteína en sangre. Numérica.

Limpieza de datos

Se transforman las variables categóricas en factores

hcvdat$Sex <- as.factor(hcvdat$Sex)
hcvdat$Category <- as.factor(hcvdat$Category)

La variable Category del dataset original puede tener los valores:

levels(hcvdat$Category)
## [1] "0=Blood Donor"          "0s=suspect Blood Donor" "1=Hepatitis"           
## [4] "2=Fibrosis"             "3=Cirrhosis"

Dado que las categorías “0=Blood Donor” y “0s=suspect Blood Donor” se refieren a personas no infectadas por HCV se cambian esas categorías por “Donor”, el resto de categorías se renombran como “Hepatitis”, “Fibrosis”, “Cirrhosis”

levels(hcvdat$Category) <- c("Donor", "Donor", "Hepatitis", "Fibrosis", "Cirrhosis")
hcvdat <- as.data.table(hcvdat)

Análisis

Vemos cómo es la distribución de la enfermedad por edad.

p <- ggplot(data = hcvdat[Category!="Donor"], aes(x = Age)) +
     geom_histogram( aes(fill = Category)) +
     scale_fill_brewer(palette="Dark2") +
     theme(plot.title = element_text(face = "bold"))
q <- p + facet_grid(cols=vars(Category))
cowplot::plot_grid(p, q, ncol = 1)

Veamos los gráficos de dispersión de los parámetros sanguíneos:

plot(select(hcvdat, ALB:PROT))

En los gráficos de dispersión se ven los puntos muy concentrados, no se aprecia linealidad entre ninguna variable.

Veamos cómo es cada parámetro sanguíneo por categoría:

geomBoxplotGraph <- function(data, x, y, title){
  g <- ggplot(data, aes(x, y, colour = x)) +
    geom_boxplot() +
    labs(title = title) +
    scale_fill_brewer(palette="Dark2") +
    theme(axis.text.x = element_text(angle = 30))
  return(g)
}

g.ALB <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$ALB, "Albúmina (ALB)")
g.ALP <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$ALP, "Fosfatasa Alcalina (ALP)")
g.ALT <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$ALT, "Transaminasa Alcalina (ALT)")
g.AST <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$AST, "Aspartato de Aminotransferasa (AST)")
g.BIL <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$BIL, "Bilirrubina (BIL)")
g.CHE <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$CHE, "Colinesterasa (CHE)")
g.CHOL <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$ALB, "Colesterol (CHOL)")
g.CREA <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$ALB, "Creatinina (CREA)")
g.GGT <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$ALB, "Gamma Glutamil Transferasa (GGT)")
g.PROT <- geomBoxplotGraph(hcvdat, hcvdat$Category, hcvdat$ALB, "Proteína (PROT)")
cowplot::plot_grid(g.ALB, g.ALP , g.ALT, g.AST, g.BIL, g.CHE, g.CHOL, g.CREA, g.GGT, g.PROT, ncol=2)

Observando las proyecciones de las cajas sobre el eje y, puede parecer que en algunos casos se puede aislar alguna categoría de las otras en función de los valores de la variable. Vamos a ver la nube de puntos para comprobar si eso es posible o no.

# Se crea un data table alargando hcvdat de manera que la columna _Value_ contiene los valores de cada parámetro sanguíneo y los nombres de éstas columnas pasan a ser categorías.
hcvdat_pt <- select(hcvdat, X, ALB:PROT) %>% gather(Parameter, Value, -X)
hcvdat_pt <- merge.data.table(hcvdat_pt, hcvdat[,.(X , Category)], by = "X")

f <- ggplot(hcvdat_pt, aes(Parameter, Value) ) +
  geom_point(aes(colour = Category, shape = Category)) +
  labs(title = "Parámetros sanguíneos") +
  scale_fill_brewer(palette="Dark2") +
  theme(axis.text.x = element_text(angle = 30))
f

Vemos que se solapan los rangos de los valores que toma cada categoría en cada variable y, por tanto, no es posible aislar los puntos en cada caso en varios tramos. Además, en dimensiones superiores es muy posible que no se puedan aislar con hiperplanos y los puntos estarán lo suficientemente mezclados en el espacio como para no tener éxito al aplicar un modelo de clasificación por cercanía.

Veamos alguna nube de puntos en dimensión 2 y 3 para comprobarlo.

geomPointGraph <- function(data, x, y, cat, title){
  g <- ggplot(data, aes(x, y) ) +
    geom_point(aes(colour = cat)) +
    labs(title = title) +
    scale_fill_brewer(palette="Dark2")
  return(g)
}

f.ALP <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$ALP, hcvdat$Category, "ALB - ALP")
f.ALT <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$ALT, hcvdat$Category, "ALB -ALT")
f.AST <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$AST, hcvdat$Category, "ALB - AST")
f.BIL <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$BIL, hcvdat$Category, "ALB - BIL")
f.CHE <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$CHE, hcvdat$Category, "ALB - CHE")
f.CHOL <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$CHOL, hcvdat$Category, "ALB - CHOL")
f.CREA <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$CREA, hcvdat$Category, "ALB - CREA")
f.GGT <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$GGT, hcvdat$Category, "ALB - GGT")
f.PROT <- geomPointGraph(hcvdat, hcvdat$ALB, hcvdat$PROT, hcvdat$Category, "ALB - PROT")
cowplot::plot_grid(f.ALP , f.ALT, f.AST, f.BIL, f.CHE, f.CHOL, f.CREA, f.GGT, f.PROT, ncol=3)

with(hcvdat,scatterplot3d(AST, ALP, CHOL, color=as.numeric(Category), pch = 19))

with(hcvdat,scatterplot3d(ALB, ALT, BIL, color=as.numeric(Category), pch = 19))

with(hcvdat,scatterplot3d(CHE, CREA, GGT, color=as.numeric(Category), pch = 19))

Elección del modelo

En el análisis descartábamos usar un modelo de clasificación por cercanía, por tanto, no aplicaremos el modelo KNN.

Hemos visto gráficamente que no hay linealidad entre las variables, así que, podríamos usar un modelo de Máquinas de Vectores Soporte (SVM) con un kernel no lineal.

Reforzaremos el estudio con un modelo Ranger Forest y compararemos.

Transformaciones de los datos

Para aplicar el modelo SVM se usarán únicamente variables numéricas. Eliminaremos la variable categórica Sex sin perder la información que ésta aporta transformando cada variable numérica en dos variables distribuyendo los valores por sexo.

Sustituiremos los valores NA por 0 para evitar errores de programación.

#' Separa cada variable numérica en dos distribuyendo los valores por sexo
#' Transforma NA en 0
featureEngine <- function(data){
  dum_sex <- fastDummies::dummy_cols(data,select_columns = c("Sex"), remove_selected_columns    = TRUE)
  data_fe <- dum_sex %>% 
    transmute(Category, 
              Age_m = Age*Sex_m, Age_f = Age*Sex_f,
              ALB_m = ALB*Sex_m, ALB_f = ALB*Sex_f,
              ALP_m = ALP*Sex_m, ALP_f = ALP*Sex_f,
              ALT_m = ALT*Sex_m, ALT_f = ALT*Sex_f,
              AST_m = AST*Sex_m, AST_f = AST*Sex_f,
              BIL_m = BIL*Sex_m, BIL_f = BIL*Sex_f,
              CHE_m = CHE*Sex_m, CHE_f = CHE*Sex_f,
              CHOL_m = CHOL*Sex_m, CHOL_f = CHOL*Sex_f,
              CREA_m = CREA*Sex_m, CREA_f = CREA*Sex_f,
              GGT_m = GGT*Sex_m, GGT_f = GGT*Sex_f,
              PROT_m = PROT*Sex_m, PROT_f = PROT*Sex_f)
  data_fe[is.na(data_fe)] <- 0
  
  return(as.data.table(data_fe))
}

hcvdat_fe <- featureEngine(hcvdat)
print(as.data.frame(hcvdat_fe))
##      Category Age_m Age_f ALB_m ALB_f ALP_m ALP_f ALT_m ALT_f AST_m AST_f BIL_m BIL_f CHE_m CHE_f CHOL_m CHOL_f CREA_m CREA_f GGT_m GGT_f PROT_m PROT_f
## 1       Donor    32     0  38.5   0.0  52.5   0.0   7.7   0.0  22.1   0.0   7.5   0.0  6.93  0.00   3.23   0.00  106.0    0.0  12.1   0.0   69.0    0.0
## 2       Donor    32     0  38.5   0.0  70.3   0.0  18.0   0.0  24.7   0.0   3.9   0.0 11.17  0.00   4.80   0.00   74.0    0.0  15.6   0.0   76.5    0.0
## 3       Donor    32     0  46.9   0.0  74.7   0.0  36.2   0.0  52.6   0.0   6.1   0.0  8.84  0.00   5.20   0.00   86.0    0.0  33.2   0.0   79.3    0.0
## 4       Donor    32     0  43.2   0.0  52.0   0.0  30.6   0.0  22.6   0.0  18.9   0.0  7.33  0.00   4.74   0.00   80.0    0.0  33.8   0.0   75.7    0.0
## 5       Donor    32     0  39.2   0.0  74.1   0.0  32.6   0.0  24.8   0.0   9.6   0.0  9.15  0.00   4.32   0.00   76.0    0.0  29.9   0.0   68.7    0.0
## 6       Donor    32     0  41.6   0.0  43.3   0.0  18.5   0.0  19.7   0.0  12.3   0.0  9.92  0.00   6.05   0.00  111.0    0.0  91.0   0.0   74.0    0.0
## 7       Donor    32     0  46.3   0.0  41.3   0.0  17.5   0.0  17.8   0.0   8.5   0.0  7.01  0.00   4.79   0.00   70.0    0.0  16.9   0.0   74.5    0.0
## 8       Donor    32     0  42.2   0.0  41.9   0.0  35.8   0.0  31.1   0.0  16.1   0.0  5.82  0.00   4.60   0.00  109.0    0.0  21.5   0.0   67.1    0.0
## 9       Donor    32     0  50.9   0.0  65.5   0.0  23.2   0.0  21.2   0.0   6.9   0.0  8.69  0.00   4.10   0.00   83.0    0.0  13.7   0.0   71.3    0.0
## 10      Donor    32     0  42.4   0.0  86.3   0.0  20.3   0.0  20.0   0.0  35.2   0.0  5.46  0.00   4.45   0.00   81.0    0.0  15.9   0.0   69.9    0.0
## 11      Donor    32     0  44.3   0.0  52.3   0.0  21.7   0.0  22.4   0.0  17.2   0.0  4.15  0.00   3.57   0.00   78.0    0.0  24.1   0.0   75.4    0.0
## 12      Donor    33     0  46.4   0.0  68.2   0.0  10.3   0.0  20.0   0.0   5.7   0.0  7.36  0.00   4.30   0.00   79.0    0.0  18.7   0.0   68.6    0.0
## 13      Donor    33     0  36.3   0.0  78.6   0.0  23.6   0.0  22.0   0.0   7.0   0.0  8.56  0.00   5.38   0.00   78.0    0.0  19.4   0.0   68.7    0.0
## 14      Donor    33     0  39.0   0.0  51.7   0.0  15.9   0.0  24.0   0.0   6.8   0.0  6.46  0.00   3.38   0.00   65.0    0.0   7.0   0.0   70.4    0.0
## 15      Donor    33     0  38.7   0.0  39.8   0.0  22.5   0.0  23.0   0.0   4.1   0.0  4.63  0.00   4.97   0.00   63.0    0.0  15.2   0.0   71.9    0.0
## 16      Donor    33     0  41.8   0.0  65.0   0.0  33.1   0.0  38.0   0.0   6.6   0.0  8.83  0.00   4.43   0.00   71.0    0.0  24.0   0.0   72.7    0.0
## 17      Donor    33     0  40.9   0.0  73.0   0.0  17.2   0.0  22.9   0.0  10.0   0.0  6.98  0.00   5.22   0.00   90.0    0.0  14.7   0.0   72.4    0.0
## 18      Donor    33     0  45.2   0.0  88.3   0.0  32.4   0.0  31.2   0.0  10.1   0.0  9.78  0.00   5.51   0.00  102.0    0.0  48.5   0.0   76.5    0.0
## 19      Donor    33     0  36.6   0.0  57.1   0.0  38.9   0.0  40.3   0.0  24.9   0.0  9.62  0.00   5.50   0.00  112.0    0.0  27.6   0.0   69.3    0.0
## 20      Donor    33     0  42.0   0.0  63.1   0.0  32.6   0.0  34.9   0.0  11.2   0.0  7.01  0.00   4.05   0.00  105.0    0.0  19.1   0.0   68.1    0.0
## 21      Donor    33     0  44.3   0.0  49.8   0.0  32.1   0.0  21.6   0.0  13.1   0.0  7.44  0.00   5.59   0.00  103.0    0.0  30.2   0.0   74.0    0.0
## 22      Donor    33     0  46.7   0.0  88.3   0.0  23.4   0.0  23.9   0.0   7.8   0.0  9.42  0.00   4.62   0.00   78.0    0.0  29.5   0.0   74.3    0.0
## 23      Donor    34     0  42.7   0.0  65.3   0.0  46.7   0.0  30.3   0.0  23.4   0.0 10.95  0.00   5.06   0.00   75.0    0.0  99.6   0.0   69.1    0.0
## 24      Donor    34     0  43.4   0.0  46.1   0.0  97.8   0.0  46.2   0.0  11.3   0.0  7.99  0.00   3.62   0.00   71.0    0.0  35.3   0.0   69.6    0.0
## 25      Donor    34     0  40.5   0.0  32.4   0.0  29.6   0.0  27.1   0.0   5.8   0.0 10.50  0.00   4.56   0.00   91.0    0.0  26.6   0.0   72.0    0.0
## 26      Donor    34     0  44.8   0.0  77.7   0.0  36.9   0.0  31.0   0.0  19.5   0.0 10.51  0.00   5.59   0.00   80.0    0.0  23.7   0.0   78.9    0.0
## 27      Donor    34     0  42.6   0.0  27.0   0.0  21.4   0.0  21.7   0.0   7.2   0.0  8.15  0.00   6.79   0.00   85.0    0.0  13.9   0.0   67.7    0.0
## 28      Donor    34     0  29.0   0.0  41.6   0.0  29.1   0.0  16.1   0.0   4.8   0.0  6.82  0.00   4.03   0.00   62.0    0.0  14.5   0.0   53.2    0.0
## 29      Donor    34     0  44.6   0.0  84.1   0.0  19.6   0.0  29.8   0.0   5.8   0.0  7.60  0.00   5.07   0.00   95.0    0.0   9.9   0.0   71.9    0.0
## 30      Donor    34     0  46.8   0.0  61.7   0.0  24.5   0.0  24.2   0.0  23.1   0.0 10.99  0.00   4.60   0.00   83.0    0.0  23.8   0.0   73.1    0.0
## 31      Donor    34     0  41.8   0.0  75.8   0.0  30.9   0.0  35.5   0.0   6.1   0.0  9.97  0.00   5.94   0.00   89.0    0.0  48.5   0.0   71.3    0.0
## 32      Donor    34     0  46.1   0.0  70.6   0.0  35.8   0.0  30.0   0.0   7.6   0.0  7.70  0.00   4.20   0.00   93.0    0.0  14.3   0.0   78.7    0.0
## 33      Donor    34     0  43.6   0.0  58.9   0.0  47.1   0.0  31.1   0.0  18.5   0.0  9.14  0.00   4.99   0.00   95.0    0.0  22.2   0.0   69.3    0.0
## 34      Donor    35     0  37.5   0.0  69.8   0.0  37.1   0.0  25.0   0.0   7.8   0.0 11.66  0.00   5.73   0.00   84.0    0.0  27.3   0.0   71.0    0.0
## 35      Donor    35     0  42.1   0.0  68.3   0.0  37.2   0.0  56.2   0.0  11.1   0.0  9.30  0.00   4.63   0.00   99.0    0.0  16.8   0.0   73.6    0.0
## 36      Donor    35     0  44.7   0.0  79.3   0.0  53.5   0.0  30.8   0.0   9.7   0.0 11.39  0.00   7.04   0.00   88.0    0.0  77.3   0.0   77.1    0.0
## 37      Donor    35     0  41.5   0.0 115.1   0.0  24.1   0.0  30.4   0.0   5.7   0.0  9.41  0.00   4.33   0.00   81.0    0.0  22.2   0.0   71.3    0.0
## 38      Donor    35     0  48.7   0.0  72.7   0.0  24.1   0.0  31.0   0.0  45.1   0.0  9.40  0.00   3.80   0.00   90.0    0.0  20.0   0.0   75.8    0.0
## 39      Donor    35     0  47.3   0.0  92.2   0.0  30.7   0.0  25.7   0.0   6.6   0.0 11.58  0.00   5.90   0.00   82.0    0.0  36.9   0.0   77.8    0.0
## 40      Donor    35     0  44.5   0.0  70.3   0.0  26.2   0.0  25.1   0.0   5.1   0.0 10.12  0.00   4.69   0.00   82.0    0.0  20.7   0.0   67.2    0.0
## 41      Donor    35     0  47.4   0.0  54.5   0.0  18.6   0.0  21.6   0.0  10.3   0.0  8.10  0.00   6.23   0.00   66.0    0.0  28.1   0.0   74.0    0.0
## 42      Donor    35     0  51.0   0.0  82.7   0.0  29.3   0.0  26.8   0.0   8.7   0.0 12.32  0.00   5.44   0.00   89.0    0.0  25.0   0.0   77.3    0.0
## 43      Donor    35     0  27.8   0.0  99.0   0.0  30.7   0.0  27.8   0.0   9.4   0.0  6.80  0.00   4.27   0.00   65.0    0.0  40.5   0.0   80.7    0.0
## 44      Donor    36     0  46.1   0.0  58.5   0.0  26.8   0.0  25.3   0.0   6.0   0.0  6.61  0.00   5.07   0.00   71.0    0.0  10.5   0.0   79.6    0.0
## 45      Donor    36     0  45.5   0.0  57.6   0.0  22.5   0.0  19.5   0.0   7.5   0.0  5.28  0.00   4.06   0.00   88.0    0.0  62.5   0.0   71.6    0.0
## 46      Donor    36     0  41.7   0.0  77.2   0.0 103.6   0.0  46.9   0.0  10.4   0.0 12.21  0.00   5.63   0.00   88.0    0.0  20.9   0.0   69.3    0.0
## 47      Donor    36     0  45.9   0.0  58.8   0.0  29.7   0.0  27.7   0.0  11.7   0.0  5.60  0.00   4.89   0.00   93.0    0.0  23.1   0.0   70.8    0.0
## 48      Donor    36     0  48.7   0.0  65.0   0.0  11.5   0.0  18.0   0.0   7.4   0.0  8.02  0.00   7.35   0.00   69.0    0.0  14.2   0.0   73.4    0.0
## 49      Donor    36     0  53.0   0.0  66.4   0.0  40.8   0.0  23.2   0.0   7.5   0.0  8.73  0.00   5.81   0.00   75.0    0.0  36.1   0.0   77.3    0.0
## 50      Donor    36     0  47.8   0.0  89.0   0.0  48.5   0.0  38.4   0.0   8.6   0.0  8.26  0.00   5.62   0.00   96.0    0.0  21.9   0.0   76.2    0.0
## 51      Donor    36     0  42.6   0.0  65.3   0.0  35.8   0.0  27.1   0.0  15.7   0.0 10.66  0.00   4.38   0.00   96.0    0.0  34.7   0.0   71.0    0.0
## 52      Donor    36     0  42.4   0.0  47.3   0.0  23.0   0.0  25.5   0.0   6.1   0.0  9.46  0.00   5.29   0.00   79.0    0.0  17.5   0.0   73.8    0.0
## 53      Donor    36     0  48.9   0.0  82.8   0.0  16.9   0.0  24.4   0.0   8.9   0.0  8.91  0.00   5.10   0.00   97.0    0.0  14.8   0.0   79.9    0.0
## 54      Donor    37     0  31.4   0.0 106.0   0.0  16.6   0.0  17.0   0.0   2.4   0.0  5.95  0.00   5.30   0.00   68.0    0.0  22.9   0.0   72.3    0.0
## 55      Donor    37     0  42.9   0.0  70.7   0.0  16.3   0.0  24.1   0.0  15.7   0.0  9.03  0.00   6.80   0.00   93.0    0.0  70.1   0.0   73.4    0.0
## 56      Donor    37     0  44.0   0.0  57.4   0.0  26.1   0.0  24.6   0.0   9.7   0.0 10.41  0.00   6.17   0.00   83.0    0.0  38.9   0.0   76.5    0.0
## 57      Donor    37     0  41.5   0.0  64.6   0.0  23.7   0.0  29.9   0.0   9.3   0.0  5.49  0.00   3.97   0.00  100.0    0.0  10.4   0.0   69.3    0.0
## 58      Donor    37     0  47.9   0.0  68.8   0.0  40.3   0.0  46.9   0.0   6.0   0.0  9.76  0.00   6.42   0.00   81.0    0.0  22.7   0.0   80.6    0.0
## 59      Donor    37     0  44.8   0.0  94.3   0.0  32.2   0.0  36.7   0.0   6.3   0.0  9.76  0.00   4.12   0.00  113.0    0.0  23.8   0.0   72.5    0.0
## 60      Donor    37     0  38.6   0.0  61.2   0.0  24.6   0.0  31.9   0.0   7.9   0.0  6.02  0.00   4.63   0.00   72.0    0.0  10.3   0.0   56.3    0.0
## 61      Donor    37     0  51.2   0.0  84.5   0.0  18.8   0.0  24.7   0.0   9.9   0.0  8.62  0.00   6.59   0.00   94.0    0.0  25.3   0.0   76.3    0.0
## 62      Donor    37     0  41.9   0.0  77.5   0.0  24.9   0.0  25.8   0.0   4.1   0.0  8.70  0.00   4.36   0.00   84.0    0.0  16.0   0.0   71.5    0.0
## 63      Donor    37     0  46.1   0.0  44.3   0.0  42.7   0.0  26.5   0.0   6.4   0.0 10.86  0.00   5.05   0.00   74.0    0.0  22.2   0.0   73.1    0.0
## 64      Donor    37     0  50.4   0.0  48.5   0.0  19.4   0.0  27.5   0.0  11.6   0.0  5.78  0.00   4.93   0.00   90.0    0.0  27.8   0.0   75.0    0.0
## 65      Donor    37     0  33.9   0.0  64.0   0.0  91.7   0.0  44.7   0.0   9.1   0.0  8.35  0.00   5.40   0.00   95.0    0.0  30.3   0.0   74.7    0.0
## 66      Donor    37     0  42.9   0.0  61.8   0.0  96.1   0.0  44.1   0.0   9.6   0.0  7.82  0.00   5.10   0.00   82.0    0.0  32.3   0.0   69.3    0.0
## 67      Donor    37     0  40.8   0.0 118.9   0.0  17.2   0.0  19.2   0.0   3.2   0.0  9.17  0.00   4.26   0.00   88.0    0.0  13.5   0.0   72.0    0.0
## 68      Donor    37     0  43.6   0.0  72.8   0.0  51.4   0.0  43.7   0.0  13.8   0.0  8.16  0.00   4.88   0.00   70.0    0.0  94.5   0.0   75.2    0.0
## 69      Donor    37     0  46.4   0.0  53.3   0.0  20.2   0.0  24.9   0.0   8.7   0.0  8.63  0.00   5.90   0.00   86.0    0.0  23.3   0.0   78.9    0.0
## 70      Donor    37     0  48.7   0.0  62.3   0.0  21.0   0.0  21.1   0.0  41.9   0.0  9.71  0.00   4.02   0.00   84.0    0.0  16.0   0.0   75.1    0.0
## 71      Donor    38     0  48.1   0.0  63.2   0.0  11.7   0.0  14.7   0.0   5.1   0.0  8.83  0.00   3.87   0.00   85.0    0.0   9.5   0.0   73.1    0.0
## 72      Donor    38     0  39.9   0.0  62.9   0.0  71.7   0.0  43.9   0.0  10.4   0.0 10.90  0.00   7.01   0.00   99.0    0.0  88.3   0.0   73.1    0.0
## 73      Donor    38     0  45.5   0.0  50.2   0.0  16.3   0.0  22.8   0.0  10.9   0.0  8.73  0.00   5.88   0.00  103.0    0.0  13.8   0.0   76.1    0.0
## 74      Donor    38     0  43.4   0.0  58.9   0.0  45.7   0.0  45.7   0.0   9.2   0.0 10.86  0.00   5.74   0.00   90.0    0.0  30.0   0.0   73.9    0.0
## 75      Donor    38     0  41.2   0.0  43.8   0.0  19.9   0.0  20.5   0.0  10.1   0.0  5.95  0.00   3.91   0.00   63.0    0.0  70.8   0.0   67.4    0.0
## 76      Donor    38     0  44.7   0.0  69.4   0.0  47.4   0.0  35.1   0.0  16.7   0.0  6.90  0.00   4.14   0.00   67.0    0.0  17.3   0.0   70.1    0.0
## 77      Donor    38     0  42.0   0.0  42.7   0.0  34.8   0.0  42.2   0.0   3.3   0.0  6.10  0.00   4.74   0.00   96.0    0.0  14.6   0.0   66.7    0.0
## 78      Donor    38     0  48.4   0.0  44.9   0.0  23.4   0.0  22.1   0.0   7.9   0.0 10.53  0.00   7.51   0.00   87.0    0.0  43.2   0.0   82.6    0.0
## 79      Donor    38     0  38.3   0.0  81.5   0.0  65.9   0.0  35.3   0.0  14.0   0.0 11.00  0.00   5.46   0.00   80.0    0.0  45.2   0.0   68.1    0.0
## 80      Donor    38     0  40.5   0.0  61.7   0.0  18.6   0.0  24.7   0.0   6.7   0.0  8.47  0.00   6.05   0.00   89.0    0.0  19.6   0.0   75.6    0.0
## 81      Donor    39     0  45.1   0.0  63.9   0.0  26.0   0.0  21.3   0.0   9.3   0.0  8.57  0.00   5.24   0.00   79.0    0.0  29.4   0.0   71.2    0.0
## 82      Donor    39     0  38.8   0.0  52.5   0.0  54.3   0.0  31.3   0.0  10.1   0.0 10.68  0.00   6.26   0.00   81.0    0.0  31.5   0.0   77.2    0.0
## 83      Donor    39     0  47.0   0.0  66.5   0.0  24.8   0.0  29.1   0.0  10.5   0.0 10.04  0.00   6.26   0.00   73.0    0.0  49.8   0.0   78.4    0.0
## 84      Donor    39     0  36.6   0.0  71.3   0.0  28.9   0.0  25.9   0.0   6.1   0.0  5.70  0.00   4.66   0.00   77.0    0.0  22.6   0.0   66.3    0.0
## 85      Donor    39     0  43.9   0.0  90.1   0.0  87.9   0.0  60.6   0.0   8.6   0.0  9.94  0.00   4.64   0.00   98.0    0.0  99.3   0.0   66.2    0.0
## 86      Donor    39     0  43.4   0.0  48.6   0.0  33.4   0.0  35.0   0.0  23.4   0.0  9.68  0.00   5.55   0.00   73.0    0.0  22.1   0.0   75.2    0.0
## 87      Donor    39     0  36.0   0.0  36.5   0.0  21.5   0.0  25.7   0.0   3.3   0.0  8.43  0.00   4.85   0.00   93.0    0.0  23.1   0.0   70.5    0.0
## 88      Donor    39     0  45.7   0.0  73.4   0.0  45.5   0.0  33.8   0.0   5.0   0.0  9.07  0.00   4.41   0.00   82.0    0.0  20.6   0.0   78.9    0.0
## 89      Donor    39     0  37.5   0.0  80.2   0.0  32.6   0.0  25.3   0.0   2.7   0.0  9.30  0.00   6.85   0.00   72.0    0.0  27.5   0.0   73.1    0.0
## 90      Donor    39     0  46.4   0.0 102.9   0.0  44.4   0.0  26.2   0.0   4.1   0.0  9.29  0.00   8.89   0.00  103.0    0.0  64.0   0.0   72.2    0.0
## 91      Donor    39     0  45.8   0.0  62.5   0.0  20.7   0.0  22.8   0.0  45.5   0.0  8.61  0.00   4.78   0.00   77.0    0.0  15.9   0.0   75.5    0.0
## 92      Donor    39     0  46.1   0.0  77.1   0.0  34.9   0.0  37.6   0.0   4.1   0.0 13.86  0.00   8.11   0.00   94.0    0.0  76.9   0.0   71.1    0.0
## 93      Donor    40     0  47.8   0.0  68.0   0.0  17.5   0.0  22.3   0.0   7.7   0.0  9.94  0.00   6.09   0.00   88.0    0.0  23.3   0.0   73.9    0.0
## 94      Donor    40     0  44.5   0.0  45.7   0.0  25.9   0.0  27.6   0.0   9.2   0.0  8.93  0.00   4.49   0.00   87.0    0.0  17.0   0.0   71.2    0.0
## 95      Donor    40     0  41.4   0.0  67.5   0.0  59.8   0.0  36.8   0.0   7.3   0.0  4.18  0.00   6.02   0.00   76.0    0.0  92.7   0.0   72.5    0.0
## 96      Donor    40     0  45.0   0.0  74.2   0.0  20.9   0.0  29.1   0.0  12.0   0.0  9.10  0.00   6.29   0.00   92.0    0.0  24.1   0.0   74.1    0.0
## 97      Donor    40     0  39.1   0.0  66.5   0.0  33.3   0.0  32.9   0.0  14.8   0.0  7.87  0.00   4.91   0.00   88.0    0.0  18.5   0.0   68.8    0.0
## 98      Donor    40     0  45.1   0.0  63.4   0.0  39.6   0.0  31.4   0.0  19.7   0.0 11.31  0.00   4.74   0.00   91.0    0.0  18.2   0.0   81.1    0.0
## 99      Donor    40     0  45.4   0.0  52.9   0.0  41.3   0.0  26.2   0.0  10.6   0.0 10.27  0.00   6.85   0.00   82.0    0.0  40.2   0.0   76.6    0.0
## 100     Donor    40     0  46.9   0.0  61.8   0.0  27.4   0.0  43.0   0.0   7.0   0.0  7.26  0.00   5.09   0.00   98.0    0.0  14.2   0.0   75.3    0.0
## 101     Donor    41     0  45.1   0.0  86.8   0.0  24.0   0.0  23.9   0.0  10.6   0.0  7.84  0.00   6.23   0.00   72.0    0.0  35.3   0.0   75.1    0.0
## 102     Donor    41     0  38.5   0.0  63.9   0.0  34.3   0.0  43.4   0.0   9.6   0.0  6.80  0.00   4.13   0.00   90.0    0.0  11.4   0.0   64.1    0.0
## 103     Donor    41     0  42.3   0.0  55.9   0.0  19.6   0.0  18.9   0.0  10.9   0.0  7.15  0.00   3.29   0.00   86.0    0.0  24.5   0.0   76.1    0.0
## 104     Donor    41     0  46.9   0.0  69.0   0.0  19.7   0.0  27.3   0.0   6.1   0.0  6.39  0.00   4.55   0.00   72.0    0.0  21.6   0.0   71.3    0.0
## 105     Donor    41     0  40.2   0.0  48.2   0.0  37.0   0.0  34.9   0.0   9.2   0.0 11.35  0.00   5.56   0.00   78.0    0.0  26.6   0.0   73.3    0.0
## 106     Donor    41     0  53.3   0.0  79.0   0.0  29.5   0.0  28.5   0.0  14.1   0.0  7.96  0.00   5.90   0.00   87.0    0.0  33.8   0.0   83.4    0.0
## 107     Donor    41     0  44.7   0.0  74.9   0.0  25.2   0.0  20.2   0.0   6.3   0.0 10.34  0.00   4.23   0.00   74.0    0.0  23.7   0.0   72.1    0.0
## 108     Donor    41     0  37.4   0.0  75.1   0.0  28.0   0.0  25.7   0.0   4.1   0.0 10.62  0.00   5.57   0.00   83.0    0.0  18.6   0.0   71.9    0.0
## 109     Donor    42     0  45.3   0.0  55.3   0.0  31.0   0.0  50.0   0.0  18.5   0.0 15.43  0.00   5.88   0.00   83.0    0.0  15.4   0.0   72.4    0.0
## 110     Donor    42     0  44.1   0.0  46.8   0.0  23.8   0.0  19.4   0.0   7.0   0.0 10.83  0.00   6.28   0.00   95.0    0.0  19.7   0.0   73.0    0.0
## 111     Donor    42     0  37.8   0.0  78.6   0.0  51.4   0.0  31.8   0.0  10.1   0.0  9.66  0.00   6.15   0.00   85.0    0.0  15.1   0.0   70.8    0.0
## 112     Donor    42     0  46.3   0.0  71.4   0.0  30.3   0.0  22.5   0.0  26.9   0.0  7.95  0.00   7.30   0.00   88.0    0.0  21.8   0.0   71.8    0.0
## 113     Donor    42     0  46.4   0.0  43.7   0.0  18.7   0.0  24.3   0.0   6.3   0.0  6.59  0.00   4.78   0.00   93.0    0.0  10.1   0.0   73.1    0.0
## 114     Donor    42     0  38.1   0.0  88.7   0.0  46.7   0.0  37.0   0.0  12.5   0.0  7.26  0.00   6.76   0.00   54.0    0.0  18.4   0.0   72.1    0.0
## 115     Donor    42     0  46.9   0.0  68.7   0.0 118.1   0.0  49.3   0.0  20.2   0.0  7.93  0.00   5.62   0.00   86.0    0.0  74.9   0.0   73.8    0.0
## 116     Donor    42     0  37.8   0.0  83.7   0.0  25.3   0.0  20.0   0.0  18.6   0.0  7.52  0.00   5.07   0.00  108.0    0.0  17.4   0.0   64.1    0.0
## 117     Donor    42     0  46.2   0.0  57.7   0.0  35.6   0.0  22.9   0.0  14.8   0.0 11.01  0.00   8.60   0.00   80.0    0.0  70.1   0.0   77.5    0.0
## 118     Donor    43     0  37.0   0.0  82.0   0.0  25.3   0.0  26.2   0.0   5.4   0.0  8.42  0.00   4.96   0.00   79.0    0.0  15.9   0.0   68.4    0.0
## 119     Donor    43     0  39.7   0.0 126.0   0.0  21.9   0.0  28.9   0.0  16.2   0.0  8.48  0.00   5.30   0.00  114.0    0.0  21.4   0.0   80.3    0.0
## 120     Donor    43     0  54.4   0.0  99.3   0.0  40.2   0.0  29.5   0.0   6.1   0.0  8.84  0.00   5.92   0.00   95.0    0.0  22.3   0.0   79.3    0.0
## 121     Donor    43     0  36.3   0.0  67.3   0.0  28.7   0.0  27.9   0.0   5.5   0.0  8.55  0.00   5.27   0.00   97.0    0.0  17.1   0.0   74.2    0.0
## 122     Donor    43     0  48.6   0.0  45.0   0.0  10.5   0.0  40.5   0.0   5.3   0.0  7.09  0.00   0.00   0.00   63.0    0.0  25.1   0.0   70.0    0.0
## 123     Donor    43     0  42.9   0.0  50.7   0.0  26.4   0.0  22.0   0.0   6.4   0.0 10.20  0.00   4.72   0.00   81.0    0.0  15.2   0.0   71.8    0.0
## 124     Donor    43     0  39.4   0.0  61.8   0.0  55.0   0.0  32.5   0.0   7.1   0.0 11.94  0.00   7.84   0.00   64.0    0.0 153.5   0.0   75.6    0.0
## 125     Donor    43     0  41.5   0.0  75.6   0.0  15.3   0.0  21.2   0.0   5.2   0.0  7.36  0.00   4.71   0.00   84.0    0.0  12.9   0.0   72.2    0.0
## 126     Donor    43     0  42.8   0.0  76.9   0.0  57.7   0.0  33.0   0.0  11.3   0.0  9.63  0.00   9.43   0.00   72.0    0.0  23.3   0.0   72.9    0.0
## 127     Donor    43     0  43.9   0.0  40.7   0.0  35.8   0.0 188.7   0.0   8.7   0.0  7.70  0.00   5.41   0.00   90.0    0.0  21.6   0.0   75.4    0.0
## 128     Donor    43     0  41.2   0.0  59.4   0.0  34.3   0.0  24.2   0.0   4.1   0.0  9.64  0.00   4.93   0.00   84.0    0.0  20.8   0.0   74.5    0.0
## 129     Donor    44     0  44.4   0.0  84.9   0.0  28.0   0.0  26.1   0.0  33.9   0.0 10.28  0.00   4.68   0.00   84.0    0.0  14.1   0.0   76.9    0.0
## 130     Donor    44     0  38.4   0.0 110.8   0.0  17.2   0.0  30.7   0.0   4.6   0.0  9.51  0.00   5.12   0.00   74.0    0.0  25.2   0.0   73.6    0.0
## 131     Donor    44     0  44.5   0.0  93.6   0.0  27.5   0.0  25.5   0.0   5.4   0.0  7.79  0.00   4.59   0.00  108.0    0.0  16.7   0.0   76.8    0.0
## 132     Donor    44     0  37.4   0.0 105.7   0.0  16.2   0.0  21.3   0.0   5.2   0.0  8.69  0.00   6.02   0.00   67.0    0.0  14.0   0.0   70.9    0.0
## 133     Donor    44     0  35.5   0.0  81.7   0.0  27.5   0.0  29.5   0.0   6.4   0.0  8.81  0.00   6.65   0.00   83.0    0.0  24.1   0.0   68.0    0.0
## 134     Donor    44     0  44.0   0.0  84.3   0.0  47.4   0.0  31.3   0.0   4.1   0.0 10.28  0.00   5.42   0.00  105.0    0.0  34.2   0.0   75.3    0.0
## 135     Donor    44     0  48.6   0.0  73.5   0.0  49.6   0.0  32.5   0.0  22.6   0.0 11.24  0.00   6.68   0.00   95.0    0.0  32.2   0.0   74.0    0.0
## 136     Donor    44     0  40.8   0.0  71.6   0.0  17.2   0.0  21.0   0.0   3.5   0.0  7.38  0.00   4.46   0.00   88.0    0.0  11.4   0.0   63.4    0.0
## 137     Donor    44     0  47.3   0.0  43.9   0.0  16.2   0.0  19.3   0.0   4.7   0.0 10.02  0.00   5.85   0.00  100.0    0.0  14.9   0.0   71.2    0.0
## 138     Donor    44     0  44.6   0.0  53.9   0.0  28.4   0.0  23.8   0.0   8.8   0.0  9.47  0.00   4.87   0.00   94.0    0.0  21.3   0.0   69.2    0.0
## 139     Donor    45     0  41.4   0.0  63.2   0.0  41.4   0.0  31.6   0.0   5.8   0.0 12.28  0.00   7.29   0.00   82.0    0.0  56.0   0.0   70.6    0.0
## 140     Donor    45     0  46.5   0.0  77.8   0.0  52.9   0.0  34.0   0.0  12.1   0.0  9.82  0.00   5.58   0.00  101.0    0.0  34.9   0.0   76.2    0.0
## 141     Donor    45     0  36.2   0.0 102.6   0.0  70.8   0.0  40.3   0.0  14.5   0.0  8.69  0.00   5.98   0.00   94.0    0.0  80.6   0.0   66.6    0.0
## 142     Donor    45     0  41.7   0.0  73.2   0.0  43.6   0.0  29.4   0.0   6.4   0.0  8.89  0.00   5.31   0.00   71.0    0.0  67.4   0.0   70.3    0.0
## 143     Donor    45     0  43.2   0.0  68.2   0.0  27.8   0.0  42.3   0.0   6.6   0.0 10.93  0.00   6.61   0.00  105.0    0.0  27.2   0.0   74.5    0.0
## 144     Donor    45     0  40.3   0.0  64.4   0.0  18.8   0.0  27.2   0.0   5.2   0.0  6.71  0.00   4.25   0.00   74.0    0.0  19.7   0.0   67.2    0.0
## 145     Donor    45     0  46.4   0.0  77.0   0.0  60.3   0.0  32.9   0.0   8.8   0.0  9.38  0.00   6.27   0.00   85.0    0.0  81.1   0.0   75.5    0.0
## 146     Donor    45     0  44.3   0.0  71.5   0.0  15.9   0.0  16.3   0.0   7.3   0.0  8.00  0.00   5.35   0.00   83.0    0.0  19.8   0.0   71.3    0.0
## 147     Donor    45     0  45.7   0.0  75.4   0.0  41.4   0.0  28.6   0.0   7.7   0.0 10.88  0.00   6.25   0.00   99.0    0.0  85.4   0.0   78.8    0.0
## 148     Donor    46     0  42.6   0.0  61.6   0.0  18.6   0.0  21.4   0.0  10.2   0.0  7.00  0.00   6.13   0.00   89.0    0.0  19.9   0.0   73.7    0.0
## 149     Donor    46     0  35.7   0.0  49.2   0.0  22.7   0.0  23.0   0.0  17.4   0.0  8.51  0.00   5.85   0.00   87.0    0.0  13.4   0.0   62.1    0.0
## 150     Donor    46     0  39.7   0.0  40.3   0.0  14.6   0.0  22.3   0.0   5.3   0.0  6.30  0.00   4.66   0.00   71.0    0.0  11.7   0.0   67.2    0.0
## 151     Donor    46     0  37.9   0.0  79.9   0.0  17.7   0.0  20.1   0.0  12.7   0.0 10.10  0.00   5.38   0.00   72.0    0.0  12.7   0.0   67.7    0.0
## 152     Donor    46     0  41.8   0.0  65.6   0.0  30.5   0.0  28.2   0.0   6.1   0.0 10.68  0.00   4.72   0.00   82.0    0.0  24.8   0.0   65.0    0.0
## 153     Donor    46     0  47.7   0.0  51.6   0.0  19.7   0.0  21.8   0.0   6.3   0.0  7.25  0.00   5.19   0.00   84.0    0.0  20.9   0.0   75.2    0.0
## 154     Donor    46     0  44.8   0.0  98.0   0.0  41.0   0.0  30.6   0.0   4.0   0.0 10.92  0.00   7.42   0.00   91.0    0.0  28.8   0.0   79.8    0.0
## 155     Donor    46     0  49.1   0.0  60.0   0.0  19.5   0.0  20.5   0.0   3.1   0.0  7.81  0.00   5.02   0.00  102.0    0.0  20.8   0.0   70.2    0.0
## 156     Donor    46     0  43.0   0.0  41.0   0.0  15.1   0.0  20.7   0.0   5.1   0.0  7.87  0.00   5.35   0.00   84.0    0.0  15.4   0.0   73.2    0.0
## 157     Donor    46     0  45.9   0.0  80.1   0.0  67.5   0.0  36.7   0.0   2.9   0.0  8.73  0.00   4.68   0.00  113.0    0.0  50.1   0.0   68.8    0.0
## 158     Donor    46     0  49.7   0.0  48.2   0.0  11.5   0.0  17.6   0.0  11.2   0.0  6.74  0.00   3.71   0.00  106.0    0.0  10.6   0.0   75.2    0.0
## 159     Donor    46     0  37.3   0.0  91.6   0.0  33.4   0.0  35.9   0.0   2.6   0.0  9.74  0.00   6.73   0.00   78.0    0.0  64.2   0.0   69.9    0.0
## 160     Donor    46     0  47.4   0.0  55.9   0.0  35.2   0.0  33.5   0.0  10.2   0.0 10.61  0.00   4.95   0.00   96.0    0.0  41.7   0.0   76.3    0.0
## 161     Donor    46     0  51.8   0.0  82.6   0.0  37.3   0.0  29.1   0.0  13.4   0.0  9.97  0.00   7.40   0.00   90.0    0.0  30.1   0.0   80.3    0.0
## 162     Donor    47     0  44.7   0.0  59.3   0.0  27.8   0.0  30.5   0.0   6.9   0.0  7.37  0.00   5.10   0.00  101.0    0.0  21.1   0.0   77.2    0.0
## 163     Donor    47     0  41.6   0.0  61.0   0.0  31.5   0.0  25.6   0.0   7.3   0.0  8.59  0.00   5.66   0.00   69.0    0.0  39.1   0.0   72.9    0.0
## 164     Donor    47     0  49.5   0.0  75.2   0.0  29.6   0.0  29.0   0.0   7.3   0.0 10.67  0.00   5.96   0.00   75.0    0.0  34.9   0.0   72.4    0.0
## 165     Donor    47     0  40.8   0.0  42.8   0.0  39.0   0.0  31.7   0.0  23.5   0.0  6.44  0.00   4.86   0.00   96.0    0.0  27.8   0.0   66.4    0.0
## 166     Donor    47     0  48.0   0.0  66.5   0.0  17.5   0.0  23.2   0.0   9.9   0.0  7.09  0.00   5.06   0.00   81.0    0.0  14.9   0.0   68.1    0.0
## 167     Donor    47     0  42.1   0.0  81.6   0.0  26.4   0.0  26.4   0.0   5.5   0.0 10.50  0.00   5.95   0.00   97.0    0.0  35.3   0.0   77.5    0.0
## 168     Donor    47     0  42.2   0.0  52.9   0.0  20.7   0.0  27.1   0.0  13.9   0.0 10.15  0.00   5.15   0.00   79.0    0.0  28.8   0.0   69.5    0.0
## 169     Donor    47     0  48.3   0.0  59.3   0.0  49.9   0.0  31.7   0.0   7.1   0.0 11.09  0.00   5.56   0.00   88.0    0.0  91.5   0.0   73.0    0.0
## 170     Donor    47     0  46.2   0.0  63.0   0.0   7.0   0.0  17.4   0.0   6.5   0.0  7.06  0.00   5.23   0.00   60.0    0.0  26.6   0.0   75.4    0.0
## 171     Donor    47     0  45.3   0.0  51.6   0.0  18.4   0.0  16.9   0.0   7.1   0.0  8.96  0.00   4.29   0.00   74.0    0.0  15.7   0.0   69.1    0.0
## 172     Donor    47     0  36.7   0.0  44.8   0.0  29.3   0.0  23.5   0.0   6.9   0.0  7.38  0.00   4.44   0.00   87.0    0.0  24.4   0.0   68.3    0.0
## 173     Donor    47     0  48.0   0.0  56.4   0.0  23.0   0.0  25.7   0.0   6.5   0.0  8.32  0.00   6.30   0.00   89.0    0.0  23.3   0.0   78.0    0.0
## 174     Donor    47     0  55.4   0.0  61.2   0.0  25.4   0.0  32.9   0.0  28.3   0.0  8.39  0.00   5.25   0.00   96.0    0.0  10.3   0.0   82.1    0.0
## 175     Donor    48     0  42.5   0.0  69.2   0.0  44.6   0.0  28.3   0.0  15.8   0.0 11.92  0.00   6.76   0.00   86.0    0.0  42.9   0.0   81.5    0.0
## 176     Donor    48     0  46.2   0.0  59.9   0.0  14.6   0.0  25.7   0.0   5.3   0.0  6.93  0.00   6.29   0.00   66.0    0.0  23.4   0.0   75.8    0.0
## 177     Donor    48     0  38.2   0.0  94.9   0.0  32.0   0.0  29.4   0.0  21.5   0.0  7.93  0.00   5.36   0.00   98.0    0.0  53.0   0.0   71.8    0.0
## 178     Donor    48     0  43.1   0.0  83.9   0.0  20.8   0.0  27.4   0.0  18.3   0.0  9.82  0.00   6.14   0.00   90.0    0.0  16.4   0.0   74.9    0.0
## 179     Donor    48     0  44.7   0.0  56.4   0.0  20.9   0.0  24.2   0.0  17.5   0.0  5.49  0.00   5.65   0.00   74.0    0.0  28.5   0.0   75.0    0.0
## 180     Donor    48     0  38.8   0.0  94.7   0.0  28.6   0.0  33.4   0.0   5.1   0.0  7.93  0.00   4.27   0.00   87.0    0.0  14.7   0.0   66.8    0.0
## 181     Donor    48     0  43.4   0.0  41.2   0.0  18.4   0.0  21.2   0.0   9.8   0.0  7.19  0.00   6.37   0.00   80.0    0.0  15.8   0.0   68.9    0.0
## 182     Donor    48     0  46.0   0.0  58.1   0.0  21.4   0.0  29.3   0.0   6.9   0.0  9.36  0.00   5.70   0.00   83.0    0.0  32.3   0.0   74.1    0.0
## 183     Donor    48     0  45.7   0.0  88.5   0.0  59.1   0.0  34.0   0.0   6.5   0.0 10.81  0.00   6.25   0.00   87.0    0.0  38.3   0.0   74.1    0.0
## 184     Donor    48     0  42.6   0.0  69.1   0.0  17.6   0.0  28.3   0.0   7.7   0.0 15.40  0.00   5.07   0.00   81.0    0.0  29.9   0.0   77.8    0.0
## 185     Donor    48     0  46.4   0.0  64.1   0.0  29.3   0.0  27.6   0.0  13.2   0.0 10.07  0.00   8.28   0.00   98.0    0.0  28.9   0.0   83.3    0.0
## 186     Donor    48     0  50.4   0.0  34.6   0.0  37.2   0.0  28.0   0.0  17.3   0.0 10.87  0.00   6.97   0.00  114.0    0.0  45.2   0.0   72.9    0.0
## 187     Donor    49     0  39.1   0.0  62.1   0.0  23.8   0.0  19.6   0.0   3.5   0.0  9.19  0.00   4.82   0.00   85.0    0.0  19.4   0.0   69.8    0.0
## 188     Donor    49     0  39.7   0.0  77.3   0.0  20.2   0.0  19.0   0.0   8.8   0.0  7.26  0.00   4.98   0.00   84.0    0.0  74.5   0.0   65.4    0.0
## 189     Donor    49     0  41.2   0.0  96.0   0.0  25.0   0.0  27.7   0.0  15.6   0.0  7.12  0.00   5.61   0.00   92.0    0.0  37.8   0.0   68.7    0.0
## 190     Donor    49     0  44.7   0.0  60.2   0.0  34.6   0.0  28.5   0.0   7.1   0.0 10.14  0.00   5.68   0.00   98.0    0.0  87.0   0.0   69.8    0.0
## 191     Donor    49     0  44.4   0.0  63.3   0.0  13.5   0.0  16.4   0.0   7.3   0.0 11.19  0.00   4.49   0.00   73.0    0.0  13.6   0.0   72.3    0.0
## 192     Donor    49     0  40.2   0.0  73.8   0.0  17.9   0.0  23.6   0.0   7.6   0.0  7.99  0.00   5.31   0.00  106.0    0.0  15.9   0.0   71.4    0.0
## 193     Donor    49     0  44.3   0.0  84.1   0.0  29.0   0.0  29.0   0.0  16.2   0.0  8.18  0.00   4.65   0.00   87.0    0.0  21.9   0.0   70.8    0.0
## 194     Donor    49     0  47.8   0.0  67.9   0.0  44.2   0.0  29.9   0.0   6.9   0.0  8.76  0.00   6.23   0.00   99.0    0.0  26.9   0.0   79.5    0.0
## 195     Donor    50     0  40.0   0.0  87.8   0.0  87.5   0.0  52.6   0.0   4.8   0.0  8.70  0.00   6.46   0.00   76.0    0.0 152.5   0.0   71.0    0.0
## 196     Donor    50     0  46.6   0.0  66.3   0.0  19.5   0.0  23.7   0.0  18.5   0.0  8.27  0.00   5.73   0.00   92.0    0.0  12.1   0.0   76.7    0.0
## 197     Donor    50     0  44.3   0.0  82.5   0.0  38.6   0.0  32.9   0.0   7.3   0.0  8.57  0.00   5.95   0.00   83.0    0.0  23.4   0.0   66.6    0.0
## 198     Donor    50     0  45.7   0.0  62.6   0.0  55.9   0.0  24.3   0.0  12.8   0.0 10.79  0.00   6.42   0.00   89.0    0.0  55.2   0.0   74.2    0.0
## 199     Donor    50     0  43.5   0.0  76.2   0.0  13.1   0.0  18.8   0.0   5.6   0.0  8.11  0.00   4.55   0.00   57.0    0.0  16.5   0.0   67.0    0.0
## 200     Donor    50     0  36.0   0.0  51.0   0.0  26.1   0.0  29.0   0.0   6.5   0.0  7.50  0.00   5.75   0.00   67.0    0.0  64.0   0.0   70.5    0.0
## 201     Donor    50     0  35.5   0.0  59.4   0.0  43.9   0.0  35.8   0.0   7.6   0.0 11.23  0.00   6.56   0.00  106.0    0.0  24.9   0.0   73.2    0.0
## 202     Donor    50     0  40.3   0.0  70.5   0.0  46.4   0.0  32.3   0.0   6.8   0.0  8.11  0.00   4.06   0.00   77.0    0.0  16.9   0.0   69.2    0.0
## 203     Donor    50     0  43.8   0.0  56.9   0.0  29.5   0.0  32.8   0.0   4.1   0.0  7.77  0.00   5.80   0.00   72.0    0.0  53.6   0.0   72.5    0.0
## 204     Donor    50     0  43.1   0.0  73.7   0.0  19.0   0.0  21.8   0.0   2.9   0.0  9.45  0.00   6.06   0.00   91.0    0.0  33.3   0.0   68.9    0.0
## 205     Donor    50     0  39.7   0.0  96.5   0.0  54.8   0.0  30.8   0.0   3.3   0.0  8.98  0.00   5.66   0.00   82.0    0.0  52.4   0.0   65.8    0.0
## 206     Donor    50     0  42.2   0.0 145.0   0.0  27.5   0.0  37.9   0.0   4.5   0.0 13.71  0.00   8.80   0.00  103.0    0.0 239.0   0.0   73.1    0.0
## 207     Donor    51     0  38.0   0.0  54.8   0.0  23.8   0.0  28.6   0.0  13.5   0.0  6.33  0.00   4.65   0.00   99.0    0.0  18.3   0.0   66.4    0.0
## 208     Donor    51     0  36.8   0.0  98.5   0.0  25.5   0.0  27.7   0.0   5.0   0.0  9.49  0.00   6.08   0.00   89.0    0.0  18.2   0.0   64.9    0.0
## 209     Donor    51     0  47.2   0.0  78.1   0.0  27.4   0.0  23.9   0.0   8.4   0.0 10.14  0.00   6.54   0.00   86.0    0.0  35.3   0.0   71.6    0.0
## 210     Donor    51     0  42.6   0.0  69.1   0.0  17.6   0.0  28.3   0.0   7.7   0.0 15.40  0.00   5.07   0.00   81.0    0.0  29.9   0.0   77.8    0.0
## 211     Donor    51     0  42.0   0.0  84.3   0.0  14.7   0.0  19.2   0.0   3.2   0.0  8.19  0.00   4.68   0.00   81.0    0.0  20.9   0.0   77.1    0.0
## 212     Donor    51     0  45.9   0.0  66.7   0.0  31.8   0.0  28.1   0.0   9.0   0.0 10.08  0.00   5.61   0.00   85.0    0.0  36.2   0.0   73.0    0.0
## 213     Donor    51     0  50.8   0.0  56.0   0.0  33.2   0.0  32.9   0.0   6.3   0.0 11.33  0.00   5.93   0.00   93.0    0.0  22.4   0.0   80.3    0.0
## 214     Donor    51     0  46.3   0.0  69.4   0.0  20.1   0.0  26.8   0.0   4.5   0.0  9.99  0.00   4.14   0.00   81.0    0.0  12.3   0.0   73.9    0.0
## 215     Donor    52     0  42.3   0.0  72.6   0.0  47.4   0.0  23.8   0.0   6.0   0.0  8.62  0.00   7.20   0.00   86.0    0.0  36.1   0.0   77.6    0.0
## 216     Donor    52     0  42.2   0.0  72.2   0.0  47.9   0.0  23.7   0.0   8.6   0.0 11.91  0.00   6.29   0.00   96.0    0.0  62.5   0.0   72.9    0.0
## 217     Donor    52     0  82.2   0.0  82.2   0.0  37.0   0.0  23.7   0.0   7.8   0.0  8.90  0.00   6.09   0.00   77.0    0.0  87.8   0.0   67.4    0.0
## 218     Donor    52     0  39.3   0.0  63.6   0.0  20.7   0.0  25.3   0.0   4.4   0.0  8.26  0.00   5.35   0.00   84.0    0.0  18.9   0.0   64.4    0.0
## 219     Donor    52     0  46.8   0.0  85.5   0.0  15.2   0.0  31.9   0.0  10.3   0.0  9.09  0.00   6.56   0.00   89.0    0.0  21.8   0.0   73.3    0.0
## 220     Donor    52     0  44.7   0.0  43.5   0.0  40.9   0.0  47.2   0.0  10.4   0.0 10.08  0.00   5.00   0.00   74.0    0.0  26.5   0.0   75.4    0.0
## 221     Donor    52     0  37.2   0.0  73.6   0.0  28.9   0.0  29.8   0.0   6.6   0.0  6.80  0.00   4.94   0.00    8.0    0.0  24.1   0.0   64.2    0.0
## 222     Donor    52     0  40.7   0.0  78.6   0.0  43.3   0.0  27.1   0.0  13.4   0.0 10.95  0.00   5.22   0.00   73.0    0.0  30.0   0.0   80.9    0.0
## 223     Donor    52     0  41.2   0.0  67.4   0.0  20.4   0.0  18.8   0.0   4.3   0.0  8.51  0.00   4.97   0.00   82.0    0.0  40.4   0.0   68.5    0.0
## 224     Donor    52     0  46.6   0.0  72.2   0.0  35.0   0.0  41.1   0.0   4.6   0.0  7.70  0.00   6.92   0.00   80.0    0.0  21.5   0.0   79.6    0.0
## 225     Donor    52     0  41.0   0.0  61.4   0.0  28.7   0.0  34.8   0.0   5.4   0.0  9.36  0.00   6.66   0.00  100.0    0.0  26.8   0.0   73.6    0.0
## 226     Donor    52     0  41.6   0.0  59.1   0.0  26.3   0.0  25.6   0.0   3.0   0.0  9.55  0.00   4.50   0.00   94.0    0.0  33.0   0.0   71.1    0.0
## 227     Donor    53     0  45.3   0.0  53.0   0.0  39.6   0.0  31.3   0.0   9.6   0.0  9.96  0.00   7.22   0.00   73.0    0.0  42.9   0.0   78.6    0.0
## 228     Donor    53     0  38.7   0.0 104.0   0.0  66.9   0.0  34.3   0.0   7.8   0.0  8.07  0.00   4.60   0.00  106.0    0.0  73.7   0.0   73.2    0.0
## 229     Donor    53     0  44.5   0.0  61.2   0.0  14.4   0.0  18.1   0.0   8.0   0.0  6.95  0.00   5.00   0.00   70.0    0.0  18.3   0.0   72.0    0.0
## 230     Donor    53     0  49.0   0.0  86.0   0.0  28.9   0.0  23.9   0.0  11.8   0.0  6.09  0.00   4.00   0.00   74.0    0.0  33.6   0.0   75.8    0.0
## 231     Donor    53     0  37.8   0.0  98.1   0.0  30.5   0.0  21.1   0.0   4.0   0.0  5.02  0.00   4.42   0.00   94.0    0.0  23.2   0.0   65.2    0.0
## 232     Donor    53     0  44.8   0.0 119.7   0.0  29.2   0.0  20.7   0.0   6.0   0.0 13.80  0.00   8.78   0.00   64.0    0.0  49.3   0.0   75.4    0.0
## 233     Donor    53     0  40.5   0.0  76.1   0.0  27.8   0.0  22.0   0.0   6.3   0.0 11.14  0.00   6.96   0.00   90.0    0.0  53.1   0.0   71.3    0.0
## 234     Donor    53     0  41.7   0.0  45.3   0.0  23.2   0.0  25.1   0.0  10.8   0.0  5.68  0.00   5.78   0.00  119.0    0.0 114.9   0.0   67.9    0.0
## 235     Donor    53     0  38.1   0.0  82.5   0.0   8.0   0.0  17.5   0.0   2.4   0.0  9.13  0.00   6.28   0.00  103.0    0.0  35.8   0.0   69.9    0.0
## 236     Donor    53     0  49.2   0.0  71.8   0.0  42.8   0.0  29.4   0.0   6.8   0.0 15.10  0.00   6.24   0.00  107.0    0.0  48.3   0.0   77.8    0.0
## 237     Donor    54     0  46.9   0.0  74.7   0.0  36.2   0.0  52.6   0.0   6.1   0.0  8.84  0.00   5.20   0.00   86.0    0.0  33.2   0.0   79.3    0.0
## 238     Donor    54     0  46.0   0.0  70.2   0.0  18.6   0.0  24.7   0.0  24.1   0.0  7.83  0.00   6.24   0.00   76.0    0.0  24.3   0.0   76.8    0.0
## 239     Donor    54     0  43.0   0.0  67.0   0.0  36.1   0.0  26.1   0.0   5.0   0.0 10.20  0.00   5.98   0.00  105.0    0.0  45.4   0.0   75.9    0.0
## 240     Donor    54     0  46.4   0.0  75.1   0.0  54.1   0.0  39.6   0.0  10.6   0.0  6.59  0.00   7.43   0.00   85.0    0.0  73.2   0.0   75.2    0.0
## 241     Donor    54     0  40.8   0.0  72.0   0.0  25.9   0.0  29.2   0.0   8.5   0.0  7.10  0.00   5.79   0.00   89.0    0.0  15.6   0.0   67.9    0.0
## 242     Donor    54     0  41.6   0.0 100.4   0.0  51.8   0.0  35.7   0.0   4.3   0.0 10.37  0.00   7.29   0.00   92.0    0.0  82.6   0.0   72.4    0.0
## 243     Donor    55     0  44.1   0.0  60.0   0.0  26.3   0.0  25.9   0.0   5.1   0.0  7.23  0.00   7.30   0.00   88.0    0.0  41.6   0.0   77.7    0.0
## 244     Donor    55     0  39.0   0.0  45.8   0.0  23.5   0.0  21.2   0.0   2.4   0.0  8.41  0.00   7.73   0.00   73.0    0.0  36.3   0.0   73.0    0.0
## 245     Donor    55     0  42.9   0.0  92.6   0.0  21.6   0.0  26.1   0.0   7.4   0.0 12.86  0.00   5.73   0.00   94.0    0.0  42.9   0.0   70.1    0.0
## 246     Donor    55     0  40.0   0.0  44.9   0.0  10.2   0.0  14.1   0.0   2.6   0.0  5.98  0.00   4.55   0.00   71.0    0.0   8.8   0.0   66.3    0.0
## 247     Donor    55     0  46.2   0.0  87.1   0.0  36.9   0.0  21.0   0.0   4.5   0.0  7.55  0.00   6.33   0.00   80.0    0.0  30.2   0.0   72.2    0.0
## 248     Donor    55     0  47.6   0.0  71.9   0.0  25.8   0.0  24.5   0.0   5.8   0.0  9.24  0.00   4.63   0.00   83.0    0.0  29.1   0.0   76.7    0.0
## 249     Donor    55     0  28.1   0.0  65.5   0.0  16.6   0.0  17.5   0.0   2.8   0.0  5.58  0.00   4.39   0.00   65.0    0.0  26.2   0.0   62.4    0.0
## 250     Donor    55     0  44.7   0.0  71.6   0.0  22.9   0.0  22.1   0.0   5.5   0.0  6.82  0.00   4.61   0.00  105.0    0.0  59.2   0.0   72.7    0.0
## 251     Donor    55     0  41.5   0.0  59.5   0.0  15.4   0.0  16.2   0.0   6.8   0.0  6.35  0.00   5.22   0.00   80.0    0.0  12.4   0.0   69.9    0.0
## 252     Donor    56     0  39.9   0.0  62.9   0.0  27.2   0.0  22.8   0.0   7.7   0.0  5.74  0.00   6.75   0.00   86.0    0.0  30.7   0.0   72.5    0.0
## 253     Donor    56     0  39.4   0.0  97.9   0.0  28.2   0.0  24.7   0.0   5.9   0.0 10.40  0.00   6.61   0.00   82.0    0.0  17.8   0.0   74.1    0.0
## 254     Donor    56     0  42.9   0.0  50.0   0.0  20.4   0.0  22.1   0.0   5.4   0.0  7.28  0.00   5.37   0.00   90.0    0.0  34.6   0.0   76.0    0.0
## 255     Donor    56     0  37.9   0.0  49.2   0.0  16.6   0.0  15.7   0.0   3.7   0.0  9.90  0.00   5.30   0.00   95.0    0.0  20.8   0.0   67.1    0.0
## 256     Donor    56     0  42.1   0.0  45.6   0.0  30.0   0.0  26.7   0.0   6.1   0.0  8.90  0.00   6.40   0.00   71.0    0.0  37.6   0.0   70.1    0.0
## 257     Donor    56     0  40.2   0.0  37.1   0.0  30.1   0.0  25.1   0.0  10.2   0.0  9.69  0.00   4.93   0.00  103.0    0.0  20.7   0.0   71.9    0.0
## 258     Donor    56     0  49.5   0.0  56.3   0.0  22.1   0.0  24.9   0.0  11.5   0.0  8.56  0.00   4.69   0.00   91.0    0.0  14.7   0.0   69.6    0.0
## 259     Donor    56     0  45.7   0.0  45.3   0.0  19.5   0.0  27.0   0.0   9.3   0.0 10.62  0.00   6.04   0.00   94.0    0.0  17.4   0.0   74.5    0.0
## 260     Donor    57     0  59.7   0.0  64.5   0.0  17.3   0.0  21.2   0.0  18.9   0.0 12.07  0.00   3.97   0.00  106.0    0.0  15.1   0.0   77.6    0.0
## 261     Donor    57     0  43.5   0.0  56.2   0.0  60.4   0.0  37.3   0.0   7.3   0.0  6.79  0.00   5.99   0.00  110.0    0.0 185.2   0.0   71.8    0.0
## 262     Donor    57     0  43.3   0.0  86.8   0.0  21.2   0.0  22.2   0.0   6.8   0.0  7.87  0.00   4.91   0.00   65.0    0.0  19.2   0.0   71.3    0.0
## 263     Donor    57     0  46.4   0.0  80.1   0.0  20.2   0.0  23.9   0.0  19.2   0.0  8.02  0.00   5.31   0.00   74.0    0.0  17.1   0.0   77.5    0.0
## 264     Donor    58     0  44.0   0.0  56.0   0.0  30.6   0.0  33.0   0.0   4.8   0.0 12.37  0.00   6.33   0.00   74.0    0.0  58.7   0.0   75.8    0.0
## 265     Donor    58     0  46.8   0.0  79.3   0.0  38.0   0.0  24.1   0.0   4.7   0.0  9.51  0.00   5.07   0.00   99.0    0.0  22.9   0.0   72.4    0.0
## 266     Donor    58     0  41.3   0.0  58.9   0.0  12.8   0.0  23.4   0.0   5.4   0.0  8.17  0.00   5.70   0.00   60.0    0.0  10.8   0.0   70.1    0.0
## 267     Donor    58     0  40.9   0.0  55.8   0.0  17.5   0.0  23.0   0.0   5.3   0.0  8.52  0.00   6.41   0.00   93.0    0.0  18.5   0.0   70.9    0.0
## 268     Donor    59     0  45.7   0.0 115.4   0.0  16.4   0.0  23.8   0.0   3.7   0.0  8.20  0.00   4.46   0.00   70.0    0.0  14.3   0.0   78.5    0.0
## 269     Donor    59     0  45.3   0.0 106.5   0.0  13.5   0.0  19.2   0.0   6.9   0.0  7.97  0.00   4.86   0.00   67.0    0.0  15.7   0.0   74.6    0.0
## 270     Donor    59     0  41.9   0.0  72.4   0.0  19.3   0.0  25.5   0.0  29.8   0.0  5.60  0.00   3.09   0.00   78.0    0.0  27.2   0.0   69.0    0.0
## 271     Donor    59     0  39.8   0.0  49.4   0.0  25.4   0.0  21.4   0.0  24.7   0.0  7.50  0.00   3.69   0.00   86.0    0.0  18.7   0.0   71.9    0.0
## 272     Donor    59     0  38.4   0.0  61.2   0.0  15.9   0.0  27.2   0.0   3.0   0.0  6.88  0.00   6.89   0.00   91.0    0.0  14.0   0.0   64.5    0.0
## 273     Donor    59     0  48.9   0.0  50.3   0.0  23.7   0.0  28.1   0.0  15.8   0.0  8.97  0.00   4.33   0.00   75.0    0.0  19.0   0.0   77.6    0.0
## 274     Donor    59     0  43.8   0.0  46.6   0.0  28.3   0.0  27.4   0.0   6.1   0.0 10.56  0.00   5.47   0.00   83.0    0.0  20.3   0.0   78.5    0.0
## 275     Donor    59     0  37.8   0.0  83.7   0.0  25.3   0.0  20.0   0.0  18.6   0.0  7.52  0.00   5.07   0.00  108.0    0.0  17.4   0.0   64.1    0.0
## 276     Donor    60     0  42.2   0.0  48.8   0.0  41.0   0.0  34.8   0.0   3.6   0.0  9.60  0.00   5.60   0.00   98.0    0.0  71.4   0.0   71.6    0.0
## 277     Donor    60     0  46.3   0.0  59.7   0.0  24.4   0.0  30.4   0.0  18.0   0.0  7.05  0.00   6.20   0.00   91.0    0.0  13.8   0.0   66.9    0.0
## 278     Donor    60     0  40.4   0.0  46.8   0.0  17.7   0.0  25.7   0.0  13.5   0.0  5.79  0.00   5.42   0.00   92.0    0.0  19.2   0.0   70.0    0.0
## 279     Donor    60     0  43.4   0.0  71.5   0.0  10.2   0.0  17.4   0.0   7.5   0.0  8.11  0.00   5.31   0.00   74.0    0.0  13.3   0.0   71.5    0.0
## 280     Donor    60     0  41.1   0.0  67.2   0.0  49.0   0.0  34.4   0.0  16.4   0.0 10.14  0.00   4.65   0.00  107.0    0.0  25.5   0.0   71.9    0.0
## 281     Donor    60     0  45.2   0.0  89.4   0.0  38.6   0.0  27.2   0.0   8.6   0.0  5.19  0.00   6.01   0.00   75.0    0.0  76.9   0.0   74.4    0.0
## 282     Donor    61     0  45.9   0.0  73.3   0.0  17.1   0.0  24.3   0.0   4.8   0.0 10.01  0.00   4.95   0.00   88.0    0.0  23.5   0.0   70.8    0.0
## 283     Donor    61     0  43.4   0.0  70.1   0.0  19.9   0.0  24.0   0.0   3.6   0.0  6.89  0.00   4.58   0.00   64.0    0.0  24.9   0.0   74.2    0.0
## 284     Donor    61     0  34.3   0.0  60.5   0.0  35.4   0.0  26.6   0.0  15.2   0.0  9.03  0.00   7.62   0.00   74.0    0.0  51.4   0.0   76.0    0.0
## 285     Donor    61     0  44.8   0.0 104.9   0.0  15.0   0.0  18.8   0.0   6.5   0.0  9.38  0.00   5.42   0.00   69.0    0.0  26.2   0.0   79.6    0.0
## 286     Donor    61     0  38.9   0.0  59.5   0.0  22.8   0.0  30.9   0.0   6.3   0.0  9.45  0.00   5.23   0.00   95.0    0.0  20.3   0.0   71.4    0.0
## 287     Donor    62     0  42.1   0.0  51.4   0.0  11.8   0.0  21.8   0.0   2.7   0.0  5.70  0.00   5.25   0.00   80.0    0.0  12.9   0.0   72.0    0.0
## 288     Donor    62     0  46.6   0.0  98.0   0.0  36.7   0.0  29.4   0.0   7.0   0.0  7.56  0.00   5.52   0.00   70.0    0.0  23.1   0.0   86.5    0.0
## 289     Donor    62     0  39.6   0.0  42.7   0.0  31.3   0.0  30.9   0.0  13.5   0.0  7.17  0.00   3.81   0.00   89.0    0.0  16.3   0.0   64.8    0.0
## 290     Donor    62     0  44.7   0.0  76.5   0.0  43.7   0.0  27.5   0.0   6.9   0.0  9.94  0.00   5.74   0.00   83.0    0.0  59.3   0.0   77.8    0.0
## 291     Donor    63     0  39.5   0.0  59.6   0.0  26.2   0.0  25.4   0.0  12.4   0.0  6.78  0.00   6.18   0.00   78.0    0.0  22.6   0.0   72.7    0.0
## 292     Donor    63     0  45.3   0.0  71.3   0.0  16.6   0.0  24.1   0.0   5.7   0.0  8.92  0.00   4.69   0.00   81.0    0.0  19.8   0.0   73.7    0.0
## 293     Donor    63     0  40.8   0.0  74.3   0.0  25.0   0.0  27.5   0.0   5.5   0.0  7.74  0.00   6.35   0.00  107.0    0.0  50.4   0.0   69.3    0.0
## 294     Donor    64     0  46.0   0.0  75.9   0.0  34.8   0.0  30.6   0.0  10.8   0.0  9.43  0.00   6.69   0.00   81.0    0.0  53.7   0.0   70.7    0.0
## 295     Donor    64     0  40.1   0.0  66.7   0.0  18.3   0.0  22.5   0.0   5.7   0.0  9.65  0.00   6.37   0.00   73.0    0.0  19.1   0.0   66.0    0.0
## 296     Donor    64     0  35.1   0.0  72.5   0.0  27.2   0.0  30.5   0.0  20.8   0.0  7.99  0.00   6.47   0.00   91.0    0.0  36.2   0.0   68.7    0.0
## 297     Donor    64     0  44.5   0.0  87.8   0.0  15.1   0.0  23.2   0.0  12.3   0.0  9.49  0.00   7.70   0.00   78.0    0.0  20.0   0.0   74.3    0.0
## 298     Donor    65     0  41.0   0.0  81.8   0.0  27.9   0.0  23.6   0.0   9.1   0.0  7.46  0.00   5.84   0.00   78.0    0.0  21.2   0.0   68.2    0.0
## 299     Donor    65     0  43.1   0.0  64.8   0.0  43.1   0.0  35.6   0.0   9.5   0.0  9.60  0.00   4.03   0.00   78.0    0.0  21.9   0.0   71.5    0.0
## 300     Donor    65     0  34.8   0.0  66.2   0.0  51.9   0.0  37.5   0.0   6.6   0.0  8.39  0.00   5.91   0.00   72.0    0.0 112.8   0.0   77.0    0.0
## 301     Donor    65     0  44.7   0.0  99.4   0.0  31.9   0.0  30.5   0.0  12.2   0.0  7.15  0.00   6.31   0.00   82.0    0.0  38.5   0.0   75.7    0.0
## 302     Donor    65     0  39.1   0.0  45.8   0.0  23.1   0.0  27.5   0.0   6.4   0.0  7.00  0.00   6.23   0.00   73.0    0.0  27.1   0.0   64.3    0.0
## 303     Donor    65     0  43.6   0.0 104.0   0.0  32.3   0.0  34.2   0.0   7.7   0.0  8.23  0.00   4.69   0.00   89.0    0.0  20.8   0.0   75.5    0.0
## 304     Donor    66     0  48.4   0.0  76.0   0.0  31.9   0.0  29.6   0.0  13.8   0.0  8.81  0.00   4.17   0.00  111.0    0.0  26.2   0.0   76.7    0.0
## 305     Donor    66     0  40.6   0.0  79.6   0.0  27.0   0.0  28.0   0.0  10.1   0.0 10.88  0.00   5.48   0.00   76.0    0.0  29.8   0.0   71.8    0.0
## 306     Donor    66     0  32.6   0.0  58.3   0.0  20.3   0.0  27.3   0.0   9.4   0.0  9.40  0.00   6.80   0.00   88.0    0.0  24.6   0.0   73.1    0.0
## 307     Donor    66     0  41.0   0.0  61.4   0.0  28.7   0.0  34.8   0.0   5.4   0.0  9.36  0.00   6.66   0.00  100.0    0.0  26.8   0.0   73.6    0.0
## 308     Donor    67     0  44.8   0.0  72.8   0.0  39.4   0.0  28.4   0.0  23.3   0.0  7.84  0.00   7.02   0.00   97.0    0.0  78.3   0.0   67.5    0.0
## 309     Donor    67     0  44.4   0.0  86.5   0.0  25.2   0.0  27.3   0.0   9.1   0.0  8.85  0.00   6.43   0.00   88.0    0.0  77.2   0.0   74.8    0.0
## 310     Donor    67     0  38.7   0.0  83.8   0.0  19.4   0.0  25.8   0.0   8.7   0.0  7.95  0.00   5.53   0.00  100.0    0.0  16.6   0.0   70.4    0.0
## 311     Donor    68     0  42.9   0.0  71.1   0.0  15.0   0.0  34.8   0.0   9.3   0.0  8.39  0.00   6.64   0.00   89.0    0.0  14.5   0.0   75.5    0.0
## 312     Donor    68     0  39.3   0.0  76.7   0.0  19.7   0.0  24.6   0.0   6.3   0.0 10.51  0.00   4.15   0.00   74.0    0.0  28.1   0.0   74.2    0.0
## 313     Donor    70     0  27.8   0.0  85.7   0.0  25.4   0.0  38.9   0.0   4.2   0.0  6.06  0.00   3.96   0.00   63.0    0.0  46.0   0.0   56.9    0.0
## 314     Donor    70     0  41.0   0.0  63.5   0.0  16.9   0.0  21.6   0.0   5.9   0.0  6.03  0.00   4.74   0.00   83.0    0.0  13.5   0.0   73.7    0.0
## 315     Donor    71     0  39.0   0.0  87.9   0.0  26.1   0.0  32.1   0.0  12.2   0.0 10.30  0.00   6.31   0.00   90.0    0.0  99.7   0.0   69.8    0.0
## 316     Donor    76     0  29.2   0.0  48.9   0.0  25.2   0.0  27.2   0.0   8.3   0.0  4.52  0.00   2.79   0.00  127.0    0.0  18.3   0.0   58.1    0.0
## 317     Donor    76     0  38.0   0.0  97.1   0.0  28.6   0.0  33.1   0.0  14.1   0.0  4.83  0.00   5.56   0.00   90.0    0.0 117.6   0.0   73.8    0.0
## 318     Donor    77     0  52.2   0.0  52.2   0.0  12.0   0.0  23.5   0.0  10.9   0.0  5.51  0.00   4.41   0.00  103.0    0.0  25.8   0.0   67.2    0.0
## 319     Donor     0    32   0.0  39.9   0.0  35.2   0.0  22.0   0.0  29.8   0.0   6.3  0.00  8.16   0.00   4.37    0.0   60.0   0.0   4.5    0.0   72.5
## 320     Donor     0    32   0.0  47.4   0.0  52.5   0.0  19.1   0.0  17.1   0.0   4.6  0.00 10.19   0.00   0.00    0.0   63.0   0.0  23.0    0.0   72.2
## 321     Donor     0    32   0.0  41.1   0.0  42.8   0.0  10.1   0.0  14.1   0.0  23.2  0.00  6.08   0.00   3.75    0.0   53.0   0.0   9.3    0.0   68.9
## 322     Donor     0    32   0.0  43.5   0.0  66.2   0.0   9.2   0.0  17.8   0.0   5.7  0.00  7.14   0.00   4.38    0.0   71.0   0.0  44.6    0.0   76.1
## 323     Donor     0    33   0.0  36.0   0.0  77.5   0.0  14.8   0.0  22.0   0.0   4.4  0.00  8.61   0.00   5.26    0.0   66.0   0.0  13.1    0.0   66.1
## 324     Donor     0    33   0.0  36.9   0.0  51.7   0.0  17.4   0.0  22.0   0.0   8.3  0.00  7.00   0.00   5.02    0.0   52.0   0.0  19.1    0.0   72.0
## 325     Donor     0    33   0.0  44.3   0.0  74.0   0.0  49.7   0.0  52.3   0.0   8.5  0.00  6.49   0.00   3.34    0.0   73.0   0.0  44.7    0.0   73.8
## 326     Donor     0    33   0.0  38.1   0.0  35.2   0.0  11.9   0.0  18.3   0.0   3.0  0.00  6.09   0.00   5.22    0.0   76.0   0.0  15.4    0.0   72.0
## 327     Donor     0    33   0.0  41.0   0.0  61.1   0.0  27.0   0.0  28.0   0.0   6.0  0.00  8.36   0.00   4.93    0.0   70.0   0.0  24.7    0.0   70.5
## 328     Donor     0    33   0.0  38.2   0.0  54.4   0.0  17.3   0.0  21.2   0.0   7.1  0.00  8.67   0.00   5.69    0.0   68.0   0.0  32.1    0.0   66.9
## 329     Donor     0    33   0.0  47.6   0.0  95.5   0.0  18.8   0.0  22.2   0.0   2.4  0.00  7.84   0.00   5.57    0.0   71.0   0.0  16.9    0.0   75.0
## 330     Donor     0    33   0.0  42.4   0.0 137.2   0.0  14.2   0.0  13.1   0.0   3.4  0.00  8.23   0.00   0.00    0.0   48.0   0.0  25.7    0.0   74.4
## 331     Donor     0    33   0.0  45.9   0.0  72.0   0.0  37.8   0.0  33.5   0.0  17.7  0.00  7.32   0.00   4.25    0.0   81.0   0.0  21.5    0.0   78.3
## 332     Donor     0    33   0.0  35.4   0.0  53.5   0.0   9.8   0.0  17.6   0.0   3.8  0.00  6.00   0.00   4.48    0.0   78.0   0.0   8.0    0.0   71.5
## 333     Donor     0    33   0.0  38.5   0.0  82.2   0.0  11.9   0.0  17.0   0.0   7.3  0.00  7.23   0.00   3.92    0.0   50.0   0.0   7.0    0.0   73.3
## 334     Donor     0    33   0.0  41.2   0.0  73.1   0.0  14.3   0.0  20.8   0.0  11.1  0.00  7.40   0.00   3.22    0.0   56.0   0.0  11.4    0.0   69.9
## 335     Donor     0    33   0.0  40.6   0.0  73.7   0.0  12.6   0.0  16.3   0.0   3.1  0.00  7.75   0.00   6.36    0.0   67.0   0.0  19.5    0.0   71.4
## 336     Donor     0    34   0.0  37.3   0.0  36.3   0.0  19.9   0.0  28.7   0.0   3.8  0.00  3.90   0.00   4.94    0.0   86.0   0.0   4.9    0.0   70.7
## 337     Donor     0    34   0.0  41.9   0.0  47.4   0.0  20.8   0.0  28.5   0.0   8.0  0.00  7.66   0.00   4.61    0.0   97.0   0.0  11.2    0.0   71.9
## 338     Donor     0    34   0.0  36.3   0.0  63.2   0.0  21.4   0.0  20.4   0.0   4.6  0.00  7.41   0.00   5.17    0.0   75.0   0.0  18.7    0.0   64.2
## 339     Donor     0    34   0.0  36.2   0.0  70.9   0.0  14.3   0.0  21.6   0.0   3.7  0.00  9.82   0.00   5.59    0.0   65.0   0.0  27.4    0.0   74.3
## 340     Donor     0    34   0.0  46.5   0.0  52.3   0.0  30.5   0.0  32.3   0.0   5.7  0.00  9.05   0.00   6.28    0.0   90.0   0.0  18.5    0.0   80.6
## 341     Donor     0    34   0.0  45.5   0.0  76.9   0.0  17.4   0.0  18.6   0.0   3.2  0.00  8.45   0.00   5.10    0.0   53.0   0.0  25.8    0.0   79.7
## 342     Donor     0    34   0.0  39.7   0.0  39.3   0.0  11.2   0.0  16.4   0.0   8.4  0.00  5.27   0.00   4.68    0.0   61.0   0.0  24.3    0.0   71.5
## 343     Donor     0    35   0.0  41.0   0.0  62.6   0.0  27.9   0.0  12.0   0.0  12.8  0.00 10.34   0.00   5.90    0.0   78.0   0.0  22.8    0.0   76.1
## 344     Donor     0    35   0.0  40.5   0.0  72.4   0.0  14.5   0.0  17.9   0.0   5.8  0.00  9.38   0.00   4.13    0.0   75.0   0.0  17.8    0.0   69.9
## 345     Donor     0    35   0.0  43.4   0.0  62.6   0.0  19.2   0.0  22.0   0.0   3.0  0.00 10.03   0.00   5.07    0.0   64.0   0.0  12.4    0.0   72.8
## 346     Donor     0    35   0.0  45.6   0.0  38.2   0.0  22.0   0.0  21.9   0.0   3.0  0.00  6.94   0.00   4.69    0.0   64.0   0.0  17.4    0.0   70.4
## 347     Donor     0    35   0.0  62.9   0.0  51.2   0.0  20.7   0.0  23.0   0.0   2.9  0.00  6.33   0.00   4.62    0.0   67.0   0.0  15.2    0.0   71.9
## 348     Donor     0    35   0.0  42.0   0.0  69.0   0.0  19.9   0.0  16.6   0.0  10.8  0.00  7.85   0.00   4.43    0.0   67.0   0.0  15.1    0.0   64.1
## 349     Donor     0    35   0.0  38.0   0.0  51.3   0.0  18.3   0.0  15.3   0.0   3.9  0.00  8.63   0.00   4.91    0.0   61.0   0.0  16.2    0.0   71.8
## 350     Donor     0    35   0.0  46.9   0.0  50.8   0.0  35.4   0.0  22.1   0.0  13.1  0.00  8.27   0.00   5.70    0.0   95.0   0.0  37.3    0.0   80.7
## 351     Donor     0    35   0.0  46.1   0.0  88.7   0.0  23.1   0.0  20.0   0.0   7.7  0.00  8.41   0.00   4.79    0.0   74.0   0.0  28.1    0.0   79.3
## 352     Donor     0    35   0.0  44.7   0.0  83.2   0.0  25.3   0.0  22.6   0.0   3.9  0.00  8.02   0.00   5.73    0.0   68.0   0.0  10.8    0.0   76.4
## 353     Donor     0    36   0.0  46.4   0.0  69.1   0.0  17.7   0.0  24.3   0.0   6.6  0.00  6.50   0.00   5.62    0.0   67.0   0.0  18.5    0.0   75.5
## 354     Donor     0    36   0.0  39.7   0.0  52.0   0.0  39.9   0.0  33.5   0.0   2.9  0.00  9.00   0.00   4.18    0.0   77.0   0.0  27.0    0.0   78.5
## 355     Donor     0    36   0.0  39.9   0.0  59.0   0.0  11.3   0.0  20.4   0.0   9.4  0.00  7.60   0.00   5.51    0.0   69.0   0.0  16.0    0.0   81.0
## 356     Donor     0    36   0.0  42.7   0.0  55.1   0.0  12.4   0.0  16.0   0.0   6.8  0.00  6.63   0.00   5.05    0.0   75.0   0.0  10.4    0.0   72.8
## 357     Donor     0    37   0.0  39.2   0.0  58.1   0.0  12.0   0.0  21.0   0.0   5.3  0.00  5.96   0.00   5.80    0.0   72.0   0.0  15.6    0.0   70.7
## 358     Donor     0    37   0.0  42.1   0.0  47.5   0.0  18.3   0.0  21.7   0.0   2.8  0.00  8.29   0.00   4.36    0.0   83.0   0.0  28.9    0.0   73.4
## 359     Donor     0    37   0.0  40.5   0.0  47.3   0.0  15.3   0.0  19.4   0.0   4.9  0.00  5.40   0.00   3.95    0.0   76.0   0.0   7.1    0.0   69.0
## 360     Donor     0    38   0.0  40.0   0.0  73.5   0.0  16.6   0.0  19.2   0.0   8.3  0.00  5.23   0.00   5.52    0.0   54.0   0.0  24.0    0.0   71.0
## 361     Donor     0    38   0.0  48.5   0.0  56.2   0.0  36.0   0.0  27.9   0.0  15.3  0.00 11.07   0.00   6.06    0.0   69.0   0.0  23.5    0.0   77.3
## 362     Donor     0    38   0.0  50.3   0.0  92.1   0.0  40.1   0.0  30.9   0.0   4.2  0.00 10.02   0.00   3.97    0.0  100.0   0.0  30.5    0.0   77.3
## 363     Donor     0    38   0.0  41.2   0.0  61.9   0.0  19.4   0.0  22.9   0.0  10.5  0.00  7.86   0.00   3.61    0.0   85.0   0.0  19.5    0.0   66.6
## 364     Donor     0    38   0.0  40.3   0.0  87.2   0.0  21.4   0.0  23.9   0.0   5.5  0.00  7.52   0.00   5.73    0.0   69.0   0.0  20.1    0.0   74.0
## 365     Donor     0    38   0.0  40.0   0.0  79.3   0.0  11.9   0.0  22.0   0.0   6.5  0.00  8.33   0.00   4.58    0.0   60.0   0.0  13.7    0.0   68.1
## 366     Donor     0    39   0.0  31.4   0.0 106.0   0.0  16.6   0.0  17.0   0.0   2.4  0.00  5.95   0.00   5.30    0.0   68.0   0.0  22.9    0.0   72.3
## 367     Donor     0    39   0.0  46.4   0.0  59.2   0.0  14.1   0.0  18.9   0.0   4.5  0.00  7.90   0.00   4.55    0.0   61.0   0.0  14.5    0.0   77.3
## 368     Donor     0    40   0.0  41.7   0.0  55.3   0.0  12.4   0.0  23.5   0.0   8.2  0.00  4.80   0.00   5.32    0.0   75.0   0.0  10.6    0.0   73.5
## 369     Donor     0    40   0.0  41.6   0.0  60.4   0.0  14.7   0.0  16.3   0.0   5.7  0.00  7.61   0.00   4.57    0.0   72.0   0.0   9.8    0.0   73.1
## 370     Donor     0    40   0.0  43.2   0.0  42.4   0.0  15.7   0.0  23.6   0.0   9.7  0.00  7.56   0.00   6.74    0.0   88.0   0.0  11.5    0.0   73.2
## 371     Donor     0    40   0.0  42.9   0.0  54.7   0.0  46.2   0.0  32.8   0.0  11.8  0.00  8.29   0.00   5.25    0.0  105.0   0.0  27.9    0.0   73.9
## 372     Donor     0    40   0.0  39.9   0.0  50.2   0.0  14.9   0.0  20.4   0.0   5.1  0.00  6.49   0.00   4.92    0.0   68.0   0.0  24.1    0.0   72.8
## 373     Donor     0    41   0.0  40.4   0.0  75.7   0.0  24.3   0.0  25.2   0.0   6.0  0.00  8.95   0.00   6.01    0.0   64.0   0.0  15.8    0.0   73.0
## 374     Donor     0    41   0.0  42.4   0.0  51.3   0.0  16.3   0.0  18.3   0.0   4.0  0.00  6.68   0.00   4.24    0.0   65.0   0.0  17.1    0.0   71.9
## 375     Donor     0    41   0.0  39.3   0.0  67.9   0.0  17.6   0.0  23.4   0.0   3.7  0.00  6.57   0.00   4.33    0.0   71.0   0.0  61.0    0.0   77.1
## 376     Donor     0    41   0.0  46.2   0.0  48.3   0.0  15.8   0.0  16.6   0.0   4.3  0.00  4.55   0.00   5.18    0.0   67.0   0.0  13.0    0.0   73.7
## 377     Donor     0    41   0.0  39.8   0.0  67.9   0.0  19.4   0.0  19.5   0.0  12.2  0.00  7.41   0.00   5.02    0.0   64.0   0.0  27.3    0.0   65.5
## 378     Donor     0    42   0.0  43.4   0.0  54.0   0.0  11.3   0.0  21.3   0.0   1.8  0.00  6.43   0.00   4.43    0.0   54.0   0.0  18.6    0.0   82.3
## 379     Donor     0    42   0.0  38.7   0.0  64.1   0.0  35.9   0.0  27.8   0.0   6.0  0.00  8.18   0.00   4.87    0.0   64.0   0.0  15.2    0.0   72.1
## 380     Donor     0    43   0.0  37.6   0.0  77.1   0.0   8.3   0.0  15.9   0.0  12.5  0.00  8.37   0.00   4.49    0.0   73.0   0.0  68.9    0.0   67.1
## 381     Donor     0    43   0.0  44.1   0.0  41.4   0.0  17.6   0.0  19.8   0.0   7.4  0.00  7.52   0.00   6.05    0.0   69.0   0.0  21.3    0.0   73.2
## 382     Donor     0    43   0.0  41.2   0.0  38.2   0.0  18.6   0.0  20.5   0.0   9.3  0.00  6.15   0.00   5.44    0.0   64.0   0.0   9.7    0.0   70.9
## 383     Donor     0    43   0.0  39.0   0.0  83.1   0.0  21.3   0.0  18.8   0.0   3.5  0.00 12.80   0.00   9.03    0.0   58.0   0.0  22.7    0.0   73.1
## 384     Donor     0    43   0.0  39.0   0.0  63.0   0.0   7.3   0.0  17.5   0.0   6.4  0.00  7.01   0.00   4.94    0.0   73.0   0.0  14.6    0.0   74.4
## 385     Donor     0    43   0.0  34.7   0.0  80.7   0.0  27.0   0.0  27.9   0.0   3.7  0.00  7.18   0.00   5.55    0.0   68.0   0.0   9.2    0.0   68.2
## 386     Donor     0    43   0.0  44.8   0.0  58.8   0.0  23.0   0.0  30.1   0.0   6.6  0.00  8.70   0.00   6.08    0.0   70.0   0.0  10.4    0.0   72.8
## 387     Donor     0    43   0.0  33.7   0.0  57.5   0.0  15.1   0.0  24.8   0.0   6.9  0.00  7.91   0.00   5.37    0.0   71.0   0.0  46.0    0.0   68.4
## 388     Donor     0    43   0.0  47.8   0.0  40.9   0.0  12.9   0.0  17.2   0.0   5.5  0.00  4.31   0.00   3.96    0.0   76.0   0.0  10.4    0.0   70.7
## 389     Donor     0    44   0.0  37.4   0.0  28.9   0.0  16.8   0.0  25.8   0.0   3.1  0.00  6.70   0.00   4.45    0.0   50.0   0.0   9.2    0.0   66.3
## 390     Donor     0    44   0.0  45.6   0.0  57.6   0.0  21.0   0.0  19.1   0.0   3.7  0.00 10.36   0.00   6.68    0.0   74.0   0.0  20.8    0.0   74.4
## 391     Donor     0    44   0.0  35.5   0.0  60.0   0.0  13.7   0.0  15.0   0.0   9.1  0.00  6.71   0.00   5.29    0.0   64.0   0.0   7.4    0.0   65.2
## 392     Donor     0    44   0.0  44.0   0.0  86.1   0.0  15.6   0.0  26.1   0.0   7.6  0.00  6.23   0.00   4.72    0.0   69.0   0.0  11.8    0.0   70.5
## 393     Donor     0    44   0.0  48.3   0.0 103.3   0.0  37.2   0.0  41.5   0.0   7.0  0.00  7.49   0.00   5.04    0.0   62.0   0.0  17.8    0.0   77.5
## 394     Donor     0    44   0.0  35.8   0.0  65.7   0.0  21.2   0.0  19.2   0.0   4.3  0.00 10.19   0.00   6.13    0.0   61.0   0.0  19.6    0.0   69.4
## 395     Donor     0    44   0.0  43.0   0.0  86.5   0.0  18.3   0.0  25.0   0.0   2.2  0.00  8.45   0.00   5.90    0.0   63.0   0.0  13.6    0.0   72.7
## 396     Donor     0    44   0.0  36.3   0.0  76.4   0.0  17.1   0.0  20.8   0.0   4.6  0.00  6.80   0.00   4.27    0.0   74.0   0.0  14.3    0.0   68.0
## 397     Donor     0    44   0.0  35.5   0.0  71.0   0.0  15.8   0.0  30.0   0.0   3.7  0.00  7.56   0.00   4.43    0.0   53.0   0.0  17.8    0.0   67.7
## 398     Donor     0    45   0.0  36.7   0.0  54.9   0.0  25.5   0.0  25.3   0.0   5.7  0.00  6.91   0.00   5.42    0.0   72.0   0.0  13.7    0.0   67.5
## 399     Donor     0    45   0.0  39.5   0.0  92.2   0.0  18.7   0.0  19.4   0.0   3.5  0.00  8.32   0.00   5.38    0.0   85.0   0.0  15.8    0.0   72.2
## 400     Donor     0    45   0.0  38.6   0.0  56.0   0.0  20.6   0.0  21.5   0.0  14.1  0.00  6.92   0.00   5.48    0.0   69.0   0.0  14.9    0.0   69.9
## 401     Donor     0    45   0.0  41.7   0.0  62.4   0.0  15.9   0.0  16.8   0.0   3.7  0.00  4.38   0.00   5.05    0.0   90.0   0.0  10.0    0.0   70.5
## 402     Donor     0    45   0.0  41.8   0.0  87.5   0.0  37.1   0.0  25.6   0.0  10.3  0.00 10.25   0.00   4.56    0.0   86.0   0.0  92.3    0.0   68.4
## 403     Donor     0    45   0.0  46.4   0.0  49.1   0.0  14.9   0.0  25.5   0.0  11.0  0.00  8.77   0.00   2.86    0.0   94.0   0.0  12.0    0.0   77.1
## 404     Donor     0    45   0.0  37.5   0.0  54.3   0.0  12.9   0.0  14.8   0.0   5.9  0.00  6.95   0.00   5.29    0.0   66.0   0.0  49.4    0.0   70.1
## 405     Donor     0    45   0.0  37.0   0.0  78.2   0.0  19.9   0.0  19.1   0.0   4.3  0.00  6.60   0.00   4.73    0.0   64.0   0.0  31.8    0.0   69.6
## 406     Donor     0    45   0.0  59.8   0.0  59.8   0.0  13.2   0.0  17.4   0.0   6.9  0.00  5.62   0.00   6.42    0.0   70.0   0.0  12.3    0.0   66.6
## 407     Donor     0    46   0.0  48.8   0.0  66.3   0.0  19.7   0.0  23.6   0.0   4.3  0.00 10.57   0.00   5.88    0.0   78.0   0.0  24.2    0.0   72.4
## 408     Donor     0    46   0.0  36.7   0.0  62.3   0.0  10.8   0.0  17.4   0.0   3.7  0.00  6.17   0.00   4.07    0.0   67.0   0.0  15.1    0.0   69.0
## 409     Donor     0    46   0.0  35.8   0.0  50.8   0.0  18.6   0.0  25.2   0.0   3.8  0.00  8.50   0.00   5.85    0.0   54.0   0.0  10.1    0.0   71.5
## 410     Donor     0    46   0.0  39.9   0.0  71.3   0.0  15.4   0.0  29.5   0.0   4.6  0.00  5.95   0.00   6.94    0.0   72.0   0.0  13.4    0.0   69.5
## 411     Donor     0    46   0.0  32.4   0.0  56.5   0.0  23.8   0.0  24.8   0.0   6.4  0.00  8.22   0.00   5.19    0.0   64.0   0.0  11.0    0.0   72.0
## 412     Donor     0    46   0.0  40.1   0.0  70.1   0.0  15.7   0.0  23.8   0.0   6.0  0.00  8.41   0.00   6.03    0.0   86.0   0.0  11.0    0.0   76.4
## 413     Donor     0    46   0.0  39.9   0.0  73.9   0.0  14.0   0.0  17.2   0.0  16.3  0.00  6.93   0.00   5.11    0.0   71.0   0.0  12.7    0.0   64.7
## 414     Donor     0    46   0.0  42.9   0.0  55.1   0.0  15.2   0.0  29.8   0.0   3.6  0.00  8.37   0.00   0.00    0.0   61.0   0.0  29.0    0.0   71.9
## 415     Donor     0    46   0.0  41.1   0.0  47.5   0.0  21.0   0.0  17.7   0.0   7.1  0.00  7.55   0.00   4.42    0.0   62.0   0.0  11.9    0.0   69.8
## 416     Donor     0    46   0.0  42.3   0.0  61.9   0.0  20.0   0.0  21.8   0.0   9.7  0.00  8.80   0.00   7.09    0.0   67.0   0.0  35.0    0.0   75.2
## 417     Donor     0    46   0.0  37.9   0.0  59.5   0.0  33.0   0.0  25.0   0.0   3.7  0.00  6.06   0.00   5.30    0.0   92.0   0.0  43.9    0.0   70.0
## 418     Donor     0    46   0.0  36.8   0.0 113.2   0.0  31.2   0.0  24.8   0.0   3.8  0.00  9.60   0.00   4.83    0.0   78.0   0.0  19.9    0.0   72.7
## 419     Donor     0    46   0.0  51.3   0.0  84.1   0.0  40.6   0.0  43.6   0.0   9.2  0.00  7.10   0.00   5.62    0.0   62.0   0.0  74.9    0.0   77.1
## 420     Donor     0    47   0.0  35.6   0.0  37.5   0.0  17.6   0.0  18.0   0.0   4.7  0.00  4.32   0.00   5.59    0.0   75.0   0.0  13.0    0.0   66.0
## 421     Donor     0    47   0.0  38.7   0.0  43.4   0.0  12.1   0.0  19.4   0.0   3.0  0.00  5.35   0.00   4.60    0.0   56.0   0.0  15.7    0.0   67.8
## 422     Donor     0    47   0.0  36.4   0.0  42.0   0.0  11.1   0.0  18.3   0.0   7.2  0.00  4.97   0.00   5.47    0.0   74.0   0.0   7.9    0.0   67.0
## 423     Donor     0    47   0.0  34.6   0.0  54.1   0.0  10.2   0.0  15.3   0.0   8.4  0.00  6.50   0.00   5.10    0.0   76.0   0.0  10.6    0.0   67.7
## 424     Donor     0    47   0.0  40.3   0.0  65.0   0.0  13.5   0.0  15.2   0.0   6.4  0.00  7.16   0.00   4.55    0.0   70.0   0.0  16.5    0.0   66.2
## 425     Donor     0    48   0.0  45.6   0.0 107.2   0.0  24.4   0.0  39.0   0.0  13.8  0.00  9.77   0.00   0.00    0.0   88.0   0.0  38.0    0.0   75.1
## 426     Donor     0    48   0.0  35.2   0.0  45.4   0.0  23.4   0.0  27.1   0.0   4.9  0.00  6.83   0.00   4.35    0.0   70.0   0.0  11.8    0.0   72.1
## 427     Donor     0    48   0.0  39.2   0.0  51.0   0.0  15.3   0.0  18.4   0.0   7.6  0.00  9.17   0.00   6.66    0.0   70.0   0.0  16.2    0.0   71.7
## 428     Donor     0    48   0.0  32.0   0.0  66.3   0.0  14.2   0.0  21.3   0.0   5.5  0.00  4.72   0.00   5.23    0.0   41.0   0.0  17.2    0.0   65.6
## 429     Donor     0    48   0.0  46.3   0.0  71.8   0.0  23.0   0.0  25.2   0.0  11.1  0.00  9.41   0.00   5.84    0.0   85.0   0.0  19.1    0.0   77.4
## 430     Donor     0    48   0.0  45.3   0.0  40.6   0.0  18.5   0.0  27.7   0.0   5.7  0.00  7.48   0.00   4.64    0.0   66.0   0.0  19.6    0.0   70.6
## 431     Donor     0    48   0.0  37.5   0.0  88.3   0.0  14.7   0.0  19.6   0.0   5.4  0.00  9.28   0.00   4.68    0.0   61.0   0.0  12.3    0.0   67.9
## 432     Donor     0    48   0.0  39.6   0.0  65.9   0.0  64.3   0.0  39.5   0.0   2.8  0.00  8.80   0.00   6.14    0.0   77.0   0.0  24.1    0.0   75.8
## 433     Donor     0    48   0.0  43.7   0.0  50.1   0.0  17.3   0.0  26.3   0.0   8.1  0.00  8.15   0.00   5.38    0.0   64.0   0.0  13.4    0.0   73.1
## 434     Donor     0    48   0.0  46.8   0.0  93.3   0.0  10.0   0.0  23.2   0.0   4.3  0.00 12.41   0.00   0.00    0.0   52.0   0.0  23.9    0.0   72.4
## 435     Donor     0    48   0.0  42.5   0.0  62.2   0.0  12.1   0.0  20.1   0.0  23.1  0.00  4.01   0.00   5.58    0.0   67.0   0.0  13.0    0.0   74.2
## 436     Donor     0    48   0.0  44.4   0.0  52.5   0.0  16.4   0.0  23.4   0.0   4.5  0.00  9.06   0.00   6.78    0.0   74.0   0.0  10.3    0.0   73.1
## 437     Donor     0    48   0.0  44.4   0.0  64.5   0.0  17.2   0.0  21.1   0.0  17.3  0.00  4.93   0.00   4.05    0.0   67.0   0.0  12.1    0.0   71.2
## 438     Donor     0    48   0.0  38.8   0.0  43.9   0.0  12.8   0.0  13.3   0.0   8.6  0.00  5.63   0.00   5.31    0.0   66.0   0.0  21.4    0.0   63.2
## 439     Donor     0    49   0.0  38.8   0.0 120.2   0.0  25.2   0.0  21.5   0.0  12.0  0.00  8.29   0.00   7.11    0.0   52.0   0.0  18.6    0.0   70.7
## 440     Donor     0    49   0.0  40.9   0.0  58.4   0.0  20.1   0.0  26.5   0.0   2.6  0.00  9.77   0.00   5.99    0.0   53.0   0.0  12.7    0.0   73.9
## 441     Donor     0    49   0.0  39.1   0.0  89.4   0.0  15.4   0.0  24.1   0.0   4.1  0.00 10.03   0.00   8.36    0.0   74.0   0.0  12.0    0.0   68.1
## 442     Donor     0    49   0.0  39.3   0.0  59.4   0.0  18.3   0.0  15.0   0.0   4.8  0.00  8.03   0.00   4.58    0.0   83.0   0.0  12.5    0.0   74.3
## 443     Donor     0    49   0.0  40.5   0.0  31.3   0.0  16.2   0.0  19.4   0.0  11.2  0.00  4.95   0.00   5.10    0.0   75.0   0.0  14.9    0.0   73.2
## 444     Donor     0    49   0.0  34.9   0.0  37.9   0.0  15.3   0.0  19.4   0.0   7.1  0.00  5.30   0.00   5.88    0.0   83.0   0.0   7.9    0.0   62.5
## 445     Donor     0    49   0.0  45.4   0.0  45.9   0.0  14.3   0.0  15.9   0.0   5.8  0.00  9.05   0.00   6.81    0.0   69.0   0.0  14.5    0.0   78.2
## 446     Donor     0    49   0.0  43.3   0.0  71.5   0.0  28.4   0.0  26.0   0.0   6.2  0.00  7.68   0.00   5.91    0.0   77.0   0.0  19.1    0.0   76.9
## 447     Donor     0    50   0.0  36.9   0.0  50.6   0.0  15.5   0.0  21.7   0.0   2.1  0.00  9.97   0.00   7.01    0.0   68.0   0.0  17.6    0.0   68.4
## 448     Donor     0    50   0.0  47.6   0.0  77.2   0.0  24.0   0.0  17.5   0.0   4.8  0.00  9.27   0.00   6.41    0.0   77.0   0.0  21.3    0.0   73.5
## 449     Donor     0    50   0.0  42.5   0.0  74.0   0.0  10.9   0.0  23.0   0.0   4.6  0.00  9.42   0.00   6.33    0.0   76.0   0.0   9.0    0.0   68.8
## 450     Donor     0    50   0.0  39.9   0.0  80.5   0.0  24.2   0.0  22.8   0.0   5.2  0.00  9.25   0.00   7.41    0.0   84.0   0.0  19.4    0.0   71.2
## 451     Donor     0    50   0.0  41.2   0.0  45.6   0.0  25.0   0.0  25.1   0.0   4.1  0.00  7.16   0.00   6.54    0.0   64.0   0.0  15.4    0.0   68.2
## 452     Donor     0    50   0.0  34.6   0.0  63.0   0.0  24.7   0.0  31.0   0.0  12.8  0.00  6.55   0.00   5.95    0.0   70.0   0.0  25.4    0.0   70.2
## 453     Donor     0    51   0.0  46.3   0.0  70.5   0.0  75.2   0.0  69.2   0.0   6.1  0.00  7.68   0.00   4.73    0.0   69.0   0.0  52.2    0.0   78.3
## 454     Donor     0    51   0.0  37.8   0.0  80.7   0.0  32.9   0.0  27.3   0.0   6.2  0.00  7.29   0.00   5.26    0.0   68.0   0.0  27.1    0.0   70.6
## 455     Donor     0    51   0.0  38.3   0.0  52.9   0.0  12.4   0.0  16.5   0.0   3.8  0.00  7.22   0.00   5.43    0.0   55.0   0.0  12.7    0.0   70.2
## 456     Donor     0    51   0.0  39.6   0.0  63.5   0.0  17.0   0.0  25.9   0.0   7.3  0.00  7.00   0.00   6.97    0.0   72.0   0.0  10.4    0.0   71.9
## 457     Donor     0    51   0.0  38.3   0.0  67.7   0.0  17.4   0.0  19.9   0.0   5.4  0.00  7.50   0.00   4.94    0.0   72.0   0.0   7.9    0.0   69.0
## 458     Donor     0    51   0.0  43.1   0.0  52.2   0.0  18.5   0.0  24.1   0.0   8.1  0.00  7.52   0.00   6.76    0.0   60.0   0.0  17.4    0.0   71.9
## 459     Donor     0    51   0.0  41.4   0.0 136.9   0.0  33.2   0.0  20.0   0.0   5.0  0.00 10.27   0.00   6.24    0.0   77.0   0.0 106.7    0.0   72.2
## 460     Donor     0    51   0.0  41.0   0.0  81.2   0.0  35.1   0.0  33.3   0.0   5.2  0.00  8.90   0.00   6.56    0.0   70.0   0.0  21.7    0.0   72.4
## 461     Donor     0    51   0.0  46.0   0.0  71.0   0.0  18.1   0.0  23.8   0.0  59.1  0.00  5.99   0.00   3.25    0.0   82.0   0.0  11.4    0.0   73.3
## 462     Donor     0    51   0.0  39.6   0.0  43.0   0.0  16.3   0.0  19.6   0.0   7.5  0.00  5.57   0.00   4.96    0.0   83.0   0.0  62.1    0.0   72.9
## 463     Donor     0    51   0.0  47.4   0.0 117.3   0.0  62.1   0.0  30.4   0.0   3.8  0.00 10.43   0.00   6.59    0.0   86.0   0.0  69.3    0.0   71.0
## 464     Donor     0    51   0.0  43.7   0.0  61.3   0.0  18.0   0.0  23.3   0.0   4.3  0.00  9.57   0.00   6.04    0.0   70.0   0.0  18.6    0.0   75.2
## 465     Donor     0    52   0.0  45.5   0.0  78.2   0.0  25.2   0.0  27.7   0.0   4.7  0.00  8.65   0.00   6.04    0.0   65.0   0.0  28.3    0.0   70.5
## 466     Donor     0    52   0.0  43.8   0.0  52.0   0.0  15.5   0.0  23.9   0.0   6.0  0.00  7.93   0.00   5.41    0.0   69.0   0.0  11.9    0.0   72.4
## 467     Donor     0    52   0.0  36.0   0.0  47.2   0.0  19.6   0.0  22.5   0.0   5.9  0.00  7.85   0.00   5.69    0.0   85.0   0.0  30.4    0.0   69.2
## 468     Donor     0    52   0.0  41.7   0.0  58.3   0.0  22.9   0.0  26.7   0.0  11.4  0.00  9.17   0.00   4.33    0.0   75.0   0.0  14.5    0.0   77.1
## 469     Donor     0    52   0.0  40.2   0.0  89.7   0.0  26.8   0.0  19.1   0.0   6.9  0.00  9.10   0.00   7.04    0.0   75.0   0.0  41.6    0.0   67.4
## 470     Donor     0    52   0.0  51.5   0.0  81.8   0.0  26.3   0.0  20.6   0.0   7.8  0.00  6.74   0.00   5.90    0.0   88.0   0.0  16.3    0.0   82.2
## 471     Donor     0    52   0.0  36.7   0.0  87.6   0.0  34.3   0.0  30.8   0.0  17.7  0.00 10.12   0.00   6.98    0.0   72.0   0.0  24.2    0.0   66.3
## 472     Donor     0    52   0.0  41.3   0.0  77.4   0.0  16.6   0.0  22.2   0.0   5.0  0.00  7.57   0.00   7.80    0.0   66.0   0.0  10.8    0.0   70.0
## 473     Donor     0    52   0.0  38.2   0.0  70.3   0.0  19.5   0.0  17.5   0.0   2.7  0.00 10.02   0.00   6.17    0.0   65.0   0.0  35.5    0.0   71.1
## 474     Donor     0    53   0.0  42.4   0.0  55.0   0.0  20.9   0.0  42.4   0.0   7.7  0.00  6.60   0.00   4.26    0.0   67.0   0.0  14.2    0.0   70.9
## 475     Donor     0    53   0.0  39.0   0.0  76.0   0.0  25.9   0.0  20.7   0.0   2.8  0.00 11.11   0.00   6.38    0.0   66.0   0.0  50.1    0.0   70.8
## 476     Donor     0    53   0.0  40.1   0.0  84.6   0.0  23.0   0.0  22.1   0.0   7.1  0.00  8.40   0.00   5.16    0.0   70.0   0.0  82.6    0.0   74.6
## 477     Donor     0    53   0.0  43.7   0.0  84.3   0.0  18.8   0.0  18.6   0.0   8.5  0.00 10.22   0.00   6.65    0.0   56.0   0.0  16.5    0.0   76.9
## 478     Donor     0    53   0.0  43.5   0.0  61.7   0.0  16.9   0.0  20.3   0.0   7.0  0.00  7.19   0.00   6.97    0.0   74.0   0.0  12.3    0.0   69.2
## 479     Donor     0    53   0.0  41.1   0.0  91.7   0.0  13.8   0.0  19.6   0.0   3.4  0.00  7.87   0.00   5.48    0.0   72.0   0.0  77.3    0.0   77.3
## 480     Donor     0    53   0.0  38.0   0.0  84.7   0.0  23.5   0.0  19.8   0.0  10.8  0.00  7.30   0.00   4.82    0.0   62.0   0.0  11.4    0.0   68.5
## 481     Donor     0    53   0.0  47.4   0.0  66.9   0.0  24.3   0.0  32.6   0.0  14.9  0.00 10.51   0.00   6.03    0.0   81.0   0.0  25.2    0.0   75.0
## 482     Donor     0    53   0.0  51.3   0.0  84.1   0.0  40.6   0.0  43.6   0.0   9.2  0.00  7.10   0.00   5.62    0.0   62.0   0.0  74.9    0.0   77.1
## 483     Donor     0    54   0.0  39.9   0.0  30.7   0.0  17.0   0.0  19.3   0.0   6.3  0.00  6.99   0.00   4.95    0.0   68.0   0.0  13.3    0.0   70.7
## 484     Donor     0    54   0.0  26.2   0.0  72.9   0.0  28.5   0.0  28.8   0.0   5.5  0.00  7.49   0.00   4.91    0.0   58.0   0.0  27.6    0.0   57.0
## 485     Donor     0    54   0.0  44.5   0.0  53.4   0.0  13.4   0.0  17.5   0.0   5.4  0.00  7.74   0.00   5.55    0.0   66.0   0.0  15.4    0.0   71.9
## 486     Donor     0    54   0.0  39.9   0.0  61.2   0.0  23.3   0.0  24.5   0.0   4.5  0.00  9.22   0.00   5.47    0.0   69.0   0.0  58.2    0.0   65.8
## 487     Donor     0    54   0.0  43.3   0.0  76.5   0.0  19.9   0.0  22.4   0.0   7.0  0.00  8.04   0.00   6.77    0.0   67.0   0.0  17.7    0.0   73.3
## 488     Donor     0    55   0.0  41.9   0.0  86.1   0.0  19.3   0.0  22.3   0.0   7.0  0.00  8.21   0.00   5.05    0.0   71.0   0.0  32.5    0.0   75.2
## 489     Donor     0    55   0.0  36.2   0.0 101.3   0.0  19.2   0.0  21.9   0.0   4.9  0.00  6.50   0.00   5.86    0.0   66.0   0.0  12.3    0.0   70.3
## 490     Donor     0    55   0.0  35.2   0.0  69.6   0.0  23.6   0.0  26.0   0.0   3.8  0.00  4.97   0.00   4.43    0.0   69.0   0.0  29.4    0.0   60.5
## 491     Donor     0    55   0.0  39.9   0.0  83.6   0.0  18.4   0.0  27.4   0.0   8.0  0.00  8.43   0.00   7.67    0.0   73.0   0.0  13.6    0.0   73.3
## 492     Donor     0    56   0.0  39.7   0.0  66.0   0.0  14.2   0.0  20.8   0.0   3.5  0.00  7.48   0.00   5.88    0.0   66.0   0.0   7.2    0.0   67.2
## 493     Donor     0    56   0.0  39.5   0.0  86.9   0.0  22.5   0.0  22.2   0.0   4.7  0.00  9.40   0.00   6.02    0.0   66.0   0.0  13.0    0.0   72.6
## 494     Donor     0    56   0.0  34.7   0.0  90.3   0.0  22.7   0.0  21.6   0.0   3.5  0.00  8.07   0.00   5.45    0.0   67.0   0.0   9.0    0.0   69.4
## 495     Donor     0    56   0.0  36.6   0.0 102.3   0.0  13.5   0.0  14.9   0.0   8.4  0.00  6.94   0.00   5.50    0.0   65.0   0.0  16.2    0.0   71.0
## 496     Donor     0    56   0.0  33.2   0.0  54.3   0.0  15.5   0.0  22.8   0.0   8.0  0.00  5.61   0.00   3.87    0.0   55.0   0.0  19.1    0.0   63.1
## 497     Donor     0    56   0.0  45.1   0.0  79.1   0.0  39.0   0.0  30.5   0.0   5.2  0.00  6.47   0.00   5.10    0.0   64.0   0.0 145.3    0.0   66.7
## 498     Donor     0    56   0.0  39.9   0.0  83.8   0.0  19.1   0.0  23.6   0.0   4.3  0.00  7.61   0.00   6.06    0.0   72.0   0.0  16.4    0.0   67.1
## 499     Donor     0    57   0.0  48.4   0.0  94.4   0.0   2.5   0.0  39.6   0.0   2.3  0.00  8.84   0.00   0.00    0.0   82.0   0.0   6.4    0.0   76.8
## 500     Donor     0    57   0.0  41.2   0.0  83.5   0.0  32.6   0.0  39.3   0.0   4.0  0.00 10.67   0.00   8.46    0.0   69.0   0.0  22.4    0.0   75.7
## 501     Donor     0    57   0.0  42.6   0.0  57.1   0.0  15.0   0.0  18.9   0.0   5.3  0.00  8.90   0.00   5.93    0.0   61.0   0.0  21.3    0.0   74.8
## 502     Donor     0    57   0.0  38.6   0.0  80.9   0.0  33.1   0.0  26.7   0.0   6.5  0.00  6.45   0.00   5.10    0.0   59.0   0.0  11.3    0.0   70.9
## 503     Donor     0    57   0.0  27.3   0.0  85.1   0.0  18.4   0.0  25.4   0.0   2.2  0.00  8.96   0.00   6.66    0.0   68.0   0.0  10.2    0.0   62.5
## 504     Donor     0    57   0.0  37.9   0.0  50.3   0.0  12.2   0.0  18.1   0.0   3.5  0.00  6.72   0.00   5.06    0.0   71.0   0.0  10.0    0.0   69.3
## 505     Donor     0    57   0.0  38.7   0.0  62.8   0.0  21.8   0.0  29.2   0.0   9.2  0.00  6.55   0.00   7.08    0.0   68.0   0.0  13.0    0.0   70.7
## 506     Donor     0    57   0.0  48.0   0.0  56.9   0.0   8.6   0.0  20.1   0.0   4.4  0.00  8.14   0.00   6.90    0.0   63.0   0.0  14.8    0.0   73.1
## 507     Donor     0    57   0.0  44.7   0.0  60.6   0.0  16.5   0.0  24.3   0.0   4.2  0.00 10.47   0.00   4.90    0.0   68.0   0.0  15.9    0.0   68.5
## 508     Donor     0    57   0.0  42.7   0.0  62.9   0.0  11.2   0.0  16.6   0.0  11.6  0.00 12.70   0.00   6.25    0.0   62.0   0.0   8.1    0.0   71.9
## 509     Donor     0    58   0.0  35.3   0.0  91.4   0.0  14.7   0.0  21.0   0.0  18.0  0.00  6.58   0.00   5.51    0.0   60.0   0.0  10.2    0.0   70.4
## 510     Donor     0    58   0.0  26.3   0.0  52.5   0.0  39.5   0.0  77.2   0.0   5.8  0.00  5.15   0.00   3.53    0.0   40.0   0.0  31.2    0.0   51.0
## 511     Donor     0    58   0.0  47.0   0.0  74.8   0.0  36.1   0.0  28.9   0.0   5.3  0.00  9.82   0.00   6.71    0.0   70.0   0.0  32.0    0.0   76.6
## 512     Donor     0    59   0.0  43.0   0.0  82.4   0.0  33.1   0.0  30.0   0.0   7.5  0.00  9.20   0.00   7.43    0.0   61.0   0.0  30.7    0.0   75.4
## 513     Donor     0    59   0.0  45.1   0.0  78.0   0.0  26.0   0.0  32.4   0.0   9.0  0.00  9.85   0.00   7.32    0.0   70.0   0.0  12.9    0.0   70.9
## 514     Donor     0    59   0.0  40.0   0.0  68.4   0.0  13.2   0.0  20.3   0.0   8.2  0.00  9.10   0.00   6.38    0.0   63.0   0.0  16.3    0.0   71.9
## 515     Donor     0    60   0.0  40.5   0.0  86.0   0.0  26.0   0.0  27.6   0.0   5.7  0.00  8.60   0.00   4.90    0.0   58.0   0.0  20.1    0.0   71.7
## 516     Donor     0    60   0.0  35.8   0.0  75.5   0.0  28.7   0.0  21.5   0.0   2.0  0.00  9.05   0.00   4.56    0.0   70.0   0.0  24.0    0.0   71.8
## 517     Donor     0    60   0.0  52.4   0.0  88.2   0.0  50.2   0.0  31.7   0.0   8.8  0.00  8.49   0.00   5.00    0.0   77.0   0.0  47.0    0.0   77.0
## 518     Donor     0    60   0.0  40.1   0.0  80.7   0.0  34.6   0.0  31.2   0.0  11.9  0.00  9.32   0.00   6.94    0.0   68.0   0.0  27.4    0.0   76.6
## 519     Donor     0    60   0.0  45.4   0.0  51.4   0.0  16.4   0.0  19.0   0.0   6.8  0.00 10.78   0.00   6.79    0.0   78.0   0.0  12.5    0.0   72.8
## 520     Donor     0    60   0.0  41.4   0.0  85.1   0.0  15.6   0.0  18.6   0.0  10.0  0.00  8.31   0.00   5.34    0.0  103.0   0.0  13.0    0.0   71.5
## 521     Donor     0    61   0.0  38.1   0.0  66.4   0.0  11.8   0.0  22.7   0.0   6.8  0.00  6.35   0.00   6.55    0.0   65.0   0.0  14.5    0.0   78.9
## 522     Donor     0    61   0.0  43.4   0.0  47.5   0.0  12.8   0.0  17.3   0.0   5.6  0.00  7.52   0.00   5.81    0.0   71.0   0.0  11.8    0.0   69.9
## 523     Donor     0    62   0.0  36.6   0.0  82.5   0.0  18.2   0.0  24.3   0.0  10.6  0.00  9.82   0.00   7.12    0.0   54.0   0.0  15.6    0.0   67.8
## 524     Donor     0    62   0.0  35.4   0.0  59.7   0.0  21.2   0.0  24.7   0.0   3.3  0.00  9.00   0.00   7.45    0.0   59.0   0.0  17.7    0.0   65.4
## 525     Donor     0    62   0.0  44.0   0.0  46.6   0.0  24.8   0.0  25.5   0.0   7.6  0.00  6.75   0.00   4.59    0.0   91.0   0.0  39.5    0.0   74.3
## 526     Donor     0    63   0.0  47.6   0.0  59.9   0.0  21.1   0.0  27.8   0.0   8.4  0.00  9.24   0.00   6.08    0.0   62.0   0.0  18.3    0.0   74.5
## 527     Donor     0    63   0.0  36.1   0.0  67.6   0.0  13.8   0.0  12.2   0.0   5.8  0.00  9.44   0.00   6.88    0.0   66.0   0.0  22.4    0.0   65.0
## 528     Donor     0    63   0.0  27.8   0.0  85.7   0.0  25.4   0.0  38.9   0.0   4.2  0.00  6.06   0.00   3.96    0.0   63.0   0.0  46.0    0.0   56.9
## 529     Donor     0    64   0.0  39.8   0.0  68.1   0.0  20.5   0.0  24.8   0.0   5.8  0.00  7.53   0.00   7.58    0.0   56.0   0.0  14.2    0.0   65.8
## 530     Donor     0    64   0.0  43.0   0.0  52.7   0.0  31.6   0.0  29.2   0.0   5.5  0.00 11.69   0.00   6.00    0.0   63.0   0.0  61.9    0.0   73.4
## 531     Donor     0    65   0.0  33.0   0.0  74.3   0.0  13.2   0.0  16.8   0.0   4.1  0.00  7.46   0.00   5.76    0.0   52.0   0.0   9.1    0.0   64.2
## 532     Donor     0    68   0.0  41.4   0.0 102.3   0.0  38.4   0.0  26.4   0.0   6.8  0.00  8.50   0.00   6.79    0.0   59.0   0.0  23.8    0.0   68.9
## 533     Donor     0    70   0.0  40.0   0.0  97.9   0.0  15.1   0.0  15.9   0.0   6.8  0.00 11.46   0.00   5.08    0.0   62.0   0.0  19.2    0.0   65.3
## 534     Donor    47     0  22.5   0.0 124.0   0.0  79.5   0.0  46.7   0.0   2.3   0.0  6.83  0.00   4.30   0.00  170.0    0.0 345.6   0.0   58.6    0.0
## 535     Donor    48     0  24.9   0.0 116.9   0.0  49.2   0.0  24.3   0.0   4.9   0.0  3.44  0.00   5.25   0.00   29.0    0.0  83.0   0.0   47.8    0.0
## 536     Donor    49     0  21.6   0.0  42.2   0.0   9.5   0.0  10.6   0.0   2.4   0.0  3.75  0.00   3.01   0.00   64.0    0.0  38.9   0.0   44.8    0.0
## 537     Donor    55     0  47.3   0.0 106.0   0.0 208.8   0.0 130.6   0.0   0.8   0.0 14.80  0.00   8.08   0.00   76.0    0.0  71.6   0.0   78.3    0.0
## 538     Donor    71     0  14.9   0.0  69.8   0.0  19.7   0.0  95.2   0.0   9.8   0.0 13.30  0.00   2.61   0.00    9.0    0.0   7.6   0.0   47.0    0.0
## 539     Donor    74     0  20.3   0.0  84.0   0.0  22.8   0.0  43.0   0.0   5.7   0.0  4.91  0.00   3.19   0.00   52.0    0.0 218.3   0.0   47.8    0.0
## 540     Donor     0    59   0.0  19.3   0.0 208.2   0.0 325.3   0.0 146.6   0.0   6.9  0.00  5.33   0.00   4.72    0.0   32.0   0.0 295.6    0.0   53.1
## 541 Hepatitis    38     0  45.0   0.0  56.3   0.0   0.0   0.0  33.1   0.0   7.0   0.0  9.58  0.00   6.00   0.00   77.9    0.0  18.9   0.0   63.0    0.0
## 542 Hepatitis    19     0  41.0   0.0   0.0   0.0  87.0   0.0  67.0   0.0  12.0   0.0  7.55  0.00   3.90   0.00   62.0    0.0  65.0   0.0   75.0    0.0
## 543 Hepatitis    23     0  47.0   0.0  19.1   0.0  38.9   0.0 164.2   0.0  17.0   0.0  7.09  0.00   3.20   0.00   79.3    0.0  90.4   0.0   70.1    0.0
## 544 Hepatitis    25     0  42.0   0.0  38.2   0.0  63.3   0.0 187.7   0.0  14.0   0.0  6.00  0.00   4.28   0.00   66.9    0.0  40.2   0.0   70.5    0.0
## 545 Hepatitis    27     0  45.0   0.0  27.5   0.0  10.5   0.0  37.8   0.0  10.0   0.0  8.77  0.00   3.20   0.00   55.2    0.0  35.9   0.0   74.5    0.0
## 546 Hepatitis    29     0  49.0   0.0   0.0   0.0  53.0   0.0  39.0   0.0  15.0   0.0  8.79  0.00   3.60   0.00   79.0    0.0  37.0   0.0   90.0    0.0
## 547 Hepatitis    30     0  45.0   0.0   0.0   0.0  66.0   0.0  45.0   0.0  14.0   0.0 12.16  0.00   6.10   0.00   86.0    0.0  43.0   0.0   77.0    0.0
## 548 Hepatitis    32     0  45.0   0.0  34.6   0.0  44.3   0.0  96.2   0.0  16.0   0.0 10.11  0.00   6.28   0.00   81.2    0.0  48.1   0.0   82.1    0.0
## 549 Hepatitis    32     0  41.0   0.0  34.4   0.0  12.1   0.0  60.9   0.0   6.0   0.0 13.80  0.00   5.48   0.00   45.4    0.0  33.1   0.0   71.1    0.0
## 550 Hepatitis    34     0  46.0   0.0  36.7   0.0   7.4   0.0  31.6   0.0   9.0   0.0  9.71  0.00   5.37   0.00   82.3    0.0  34.4   0.0   71.6    0.0
## 551 Hepatitis    35     0  47.0   0.0  37.9   0.0  13.3   0.0  48.4   0.0   8.0   0.0 10.30  0.00   4.14   0.00   69.2    0.0  68.2   0.0   76.0    0.0
## 552 Hepatitis    36     0  44.0   0.0  32.9   0.0   9.4   0.0  32.0   0.0  14.0   0.0 11.42  0.00   5.73   0.00   68.6    0.0  40.6   0.0   70.9    0.0
## 553 Hepatitis    38     0  41.0   0.0  20.6   0.0  15.2   0.0  53.5   0.0  24.0   0.0 10.23  0.00   4.89   0.00   81.8    0.0  57.9   0.0   71.1    0.0
## 554 Hepatitis    41     0  42.0   0.0  39.6   0.0  26.5   0.0  77.6   0.0  42.0   0.0  9.67  0.00   9.67   0.00   57.7    0.0 143.4   0.0   75.8    0.0
## 555 Hepatitis    44     0  49.0   0.0  27.3   0.0  40.2   0.0  31.1   0.0  13.0   0.0  8.91  0.00   4.07   0.00   81.5    0.0  27.6   0.0   72.8    0.0
## 556 Hepatitis    46     0  48.0   0.0  59.5   0.0  11.6   0.0  39.0   0.0   7.0   0.0 16.41  0.00   4.65   0.00   66.4    0.0 158.2   0.0   72.7    0.0
## 557 Hepatitis    50     0  42.0   0.0  41.6   0.0  10.2   0.0  38.1   0.0  17.0   0.0  9.54  0.00   7.04   0.00   75.3    0.0  92.1   0.0   72.3    0.0
## 558 Hepatitis    51     0  43.0   0.0  37.2   0.0  21.4   0.0 132.8   0.0   5.0   0.0 10.12  0.00   5.23   0.00   76.2    0.0  76.4   0.0   76.7    0.0
## 559 Hepatitis    56     0  37.0   0.0 114.0   0.0  27.8   0.0 324.0   0.0  67.0   0.0  5.75  0.00   3.09   0.00   97.7    0.0 392.2   0.0   77.3    0.0
## 560 Hepatitis    58     0  43.0   0.0  99.1   0.0  12.2   0.0  63.2   0.0  13.0   0.0  5.95  0.00   6.15   0.00  147.3    0.0 491.0   0.0   65.6    0.0
## 561 Hepatitis     0    33   0.0  43.0   0.0  29.6   0.0   3.8   0.0  16.7   0.0   6.0  0.00  6.88   0.00   5.72    0.0   58.8   0.0  11.5    0.0   78.2
## 562 Hepatitis     0    41   0.0  37.0   0.0  31.2   0.0   8.2   0.0  38.3   0.0   7.0  0.00  7.08   0.00   5.30    0.0   60.8   0.0  24.7    0.0   82.4
## 563 Hepatitis     0    50   0.0  40.0   0.0  32.7   0.0   9.0   0.0  46.0   0.0  10.0  0.00  7.51   0.00   4.67    0.0   56.6   0.0  22.3    0.0   70.1
## 564 Hepatitis     0    61   0.0  50.0   0.0  34.4   0.0  27.4   0.0 114.4   0.0  22.0  0.00  9.48   0.00   4.62    0.0   61.9   0.0 169.8    0.0   86.0
## 565  Fibrosis    29     0  41.0   0.0  43.1   0.0   2.4   0.0  83.5   0.0   6.0   0.0 11.49  0.00   5.42   0.00   55.2    0.0 130.0   0.0   66.5    0.0
## 566  Fibrosis    40     0  39.0   0.0  43.1   0.0  23.8   0.0 114.7   0.0  11.0   0.0  9.64  0.00   4.20   0.00   70.9    0.0 127.3   0.0   81.3    0.0
## 567  Fibrosis    46     0  45.0   0.0  26.9   0.0  23.1   0.0 125.0   0.0  17.0   0.0  6.97  0.00   4.01   0.00   60.5    0.0  72.2   0.0   73.0    0.0
## 568  Fibrosis    48     0  49.0   0.0  45.2   0.0  19.3   0.0  69.1   0.0  30.0   0.0  7.76  0.00   4.22   0.00   76.7    0.0  28.4   0.0   72.3    0.0
## 569  Fibrosis    49     0  39.0   0.0   0.0   0.0 118.0   0.0  62.0   0.0  10.0   0.0  7.28  0.00   3.50   0.00   72.0    0.0  74.0   0.0   81.0    0.0
## 570  Fibrosis    49     0  46.0   0.0   0.0   0.0 114.0   0.0  75.0   0.0  16.0   0.0 10.43  0.00   5.20   0.00   72.0    0.0  59.0   0.0   82.0    0.0
## 571  Fibrosis    50     0  42.0   0.0   0.0   0.0 258.0   0.0 106.0   0.0  15.0   0.0  8.74  0.00   4.70   0.00   77.0    0.0  80.0   0.0   84.0    0.0
## 572  Fibrosis    53     0  46.0   0.0   0.0   0.0  34.0   0.0  43.0   0.0  14.0   0.0  8.77  0.00   4.00   0.00  112.0    0.0 203.0   0.0   76.0    0.0
## 573  Fibrosis    54     0  41.0   0.0  41.8   0.0  41.5   0.0 187.9   0.0  21.0   0.0  8.59  0.00   5.85   0.00   91.0    0.0 104.9   0.0   79.1    0.0
## 574  Fibrosis    57     0  47.0   0.0  29.7   0.0  10.2   0.0  55.9   0.0  12.0   0.0  6.60  0.00   4.64   0.00   70.9    0.0  69.6   0.0   80.9    0.0
## 575  Fibrosis    59     0  44.0   0.0  34.5   0.0   8.9   0.0  74.5   0.0   6.0   0.0  9.45  0.00   4.45   0.00   65.0    0.0  95.3   0.0   69.7    0.0
## 576  Fibrosis    64     0  38.0   0.0  35.7   0.0   7.1   0.0  41.3   0.0  13.0   0.0  7.10  0.00   4.52   0.00   70.0    0.0  53.0   0.0   66.8    0.0
## 577  Fibrosis    71     0  37.0   0.0   0.0   0.0 130.0   0.0  90.0   0.0  15.0   0.0  9.92  0.00   4.70   0.00   79.0    0.0  77.0   0.0   76.0    0.0
## 578  Fibrosis     0    36   0.0  46.0   0.0  39.3   0.0  67.1   0.0 161.9   0.0  13.0  0.00  9.24   0.00   4.81    0.0   65.3   0.0  60.0    0.0   73.9
## 579  Fibrosis     0    38   0.0  40.0   0.0  39.8   0.0  14.9   0.0  68.9   0.0  11.0  0.00  8.55   0.00   4.31    0.0   60.5   0.0  40.1    0.0   76.5
## 580  Fibrosis     0    57   0.0  43.0   0.0  52.1   0.0   8.3   0.0  35.8   0.0  18.0  0.00  8.61   0.00   6.19    0.0   71.4   0.0  27.9    0.0   82.0
## 581  Fibrosis     0    68   0.0  43.0   0.0  22.9   0.0   5.0   0.0  42.1   0.0  12.0  0.00  7.29   0.00   4.89    0.0   80.9   0.0  11.9    0.0   76.1
## 582  Fibrosis     0    49   0.0  39.0   0.0   0.0   0.0  46.0   0.0  39.0   0.0   9.0  0.00 10.21   0.00   3.10    0.0   89.0   0.0  53.0    0.0   79.0
## 583  Fibrosis     0    51   0.0  37.0   0.0   0.0   0.0 164.0   0.0  70.0   0.0   9.0  0.00  3.99   0.00   4.20    0.0   67.0   0.0  43.0    0.0   72.0
## 584  Fibrosis     0    56   0.0  39.0   0.0   0.0   0.0  42.0   0.0  34.0   0.0  10.0  0.00  7.75   0.00   5.00    0.0   80.0   0.0  84.0    0.0   78.0
## 585  Fibrosis     0    75   0.0  36.0   0.0   0.0   0.0 114.0   0.0 125.0   0.0  14.0  0.00  6.65   0.00   0.00    0.0   57.0   0.0 177.0    0.0   72.0
## 586 Cirrhosis    38     0  44.0   0.0   0.0   0.0  94.0   0.0  60.0   0.0  12.0   0.0  4.37  0.00   3.20   0.00   61.0    0.0  99.0   0.0   77.0    0.0
## 587 Cirrhosis    39     0  34.0   0.0 137.8   0.0   4.8   0.0  35.6   0.0   9.0   0.0  3.65  0.00   4.82   0.00  519.0    0.0 133.4   0.0   57.5    0.0
## 588 Cirrhosis    41     0  31.0   0.0  85.3   0.0   4.8   0.0  60.2   0.0 200.0   0.0  1.80  0.00   5.34   0.00  106.4    0.0 151.0   0.0   71.8    0.0
## 589 Cirrhosis    42     0  36.0   0.0  69.6   0.0  14.9   0.0 263.1   0.0  40.0   0.0  3.61  0.00   3.93   0.00   49.6    0.0  61.0   0.0   68.6    0.0
## 590 Cirrhosis    45     0  29.0   0.0  11.3   0.0   7.1   0.0 101.9   0.0  31.0   0.0  1.73  0.00   3.71   0.00   76.7    0.0  65.6   0.0   70.0    0.0
## 591 Cirrhosis    46     0  20.0   0.0   0.0   0.0  62.0   0.0 113.0   0.0 254.0   0.0  1.48  0.00   0.00   0.00  114.0    0.0 138.0   0.0    0.0    0.0
## 592 Cirrhosis    46     0  35.0   0.0 109.6   0.0   2.3   0.0  19.2   0.0  11.0   0.0  7.10  0.00   4.10   0.00 1079.1    0.0 105.6   0.0   69.1    0.0
## 593 Cirrhosis    47     0  42.0   0.0   0.0   0.0 159.0   0.0 102.0   0.0  11.0   0.0  6.29  0.00   5.50   0.00   58.0    0.0 201.0   0.0   79.0    0.0
## 594 Cirrhosis    51     0  39.0   0.0  66.0   0.0  29.6   0.0 185.0   0.0  19.0   0.0  2.00  0.00   3.60   0.00   58.3    0.0 399.5   0.0   79.4    0.0
## 595 Cirrhosis    51     0  33.0   0.0  29.6   0.0   4.5   0.0  66.6   0.0  91.0   0.0  4.02  0.00   4.08   0.00   75.9    0.0  28.5   0.0   62.3    0.0
## 596 Cirrhosis    56     0  27.0   0.0  81.1   0.0  17.0   0.0 319.8   0.0  37.0   0.0  1.42  0.00   3.54   0.00   66.9    0.0  93.7   0.0   65.3    0.0
## 597 Cirrhosis    56     0  23.0   0.0 105.6   0.0   5.1   0.0 123.0   0.0  43.0   0.0  1.80  0.00   2.40   0.00   62.7    0.0  35.9   0.0   62.8    0.0
## 598 Cirrhosis    56     0  30.0   0.0  40.4   0.0   0.9   0.0  80.3   0.0 119.0   0.0  1.88  0.00   1.43   0.00   79.3    0.0  17.6   0.0   54.2    0.0
## 599 Cirrhosis    58     0  31.0   0.0 143.1   0.0   7.0   0.0 181.8   0.0  58.0   0.0  3.29  0.00   3.92   0.00   66.4    0.0 273.7   0.0   78.1    0.0
## 600 Cirrhosis    59     0  36.0   0.0  49.7   0.0   5.2   0.0 110.1   0.0  37.0   0.0  2.29  0.00   3.68   0.00  118.2    0.0  56.9   0.0   74.8    0.0
## 601 Cirrhosis    59     0  27.0   0.0  73.8   0.0   4.0   0.0  65.2   0.0 209.0   0.0  2.47  0.00   3.61   0.00   71.7    0.0  28.5   0.0   60.6    0.0
## 602 Cirrhosis    59     0  31.0   0.0  86.3   0.0   5.4   0.0  95.4   0.0 117.0   0.0  1.57  0.00   3.51   0.00   60.5    0.0  53.6   0.0   68.5    0.0
## 603 Cirrhosis    61     0  39.0   0.0 102.9   0.0  27.3   0.0 143.2   0.0  15.0   0.0  5.38  0.00   4.88   0.00   72.3    0.0 400.3   0.0   73.4    0.0
## 604 Cirrhosis    65     0   0.0   0.0   0.0   0.0  40.0   0.0  54.0   0.0  13.0   0.0  7.50  0.00   0.00   0.00   70.0    0.0 107.0   0.0   79.0    0.0
## 605 Cirrhosis    74     0  23.0   0.0  34.1   0.0   2.1   0.0  90.4   0.0  22.0   0.0  2.50  0.00   3.29   0.00   51.0    0.0  46.8   0.0   57.1    0.0
## 606 Cirrhosis     0    42   0.0  33.0   0.0  79.0   0.0   3.7   0.0  55.7   0.0 200.0  0.00  1.72   0.00   5.16    0.0   89.1   0.0 146.3    0.0   69.9
## 607 Cirrhosis     0    49   0.0  33.0   0.0 190.7   0.0   1.2   0.0  36.3   0.0   7.0  0.00  6.92   0.00   3.82    0.0  485.9   0.0 112.0    0.0   58.5
## 608 Cirrhosis     0    52   0.0  39.0   0.0  37.0   0.0   1.3   0.0  30.4   0.0  21.0  0.00  6.33   0.00   3.78    0.0  158.2   0.0 142.5    0.0   82.7
## 609 Cirrhosis     0    58   0.0  34.0   0.0  46.4   0.0  15.0   0.0 150.0   0.0   8.0  0.00  6.26   0.00   3.98    0.0   56.0   0.0  49.7    0.0   80.6
## 610 Cirrhosis     0    59   0.0  39.0   0.0  51.3   0.0  19.6   0.0 285.8   0.0  40.0  0.00  5.77   0.00   4.51    0.0  136.1   0.0 101.1    0.0   70.5
## 611 Cirrhosis     0    62   0.0  32.0   0.0 416.6   0.0   5.9   0.0 110.3   0.0  50.0  0.00  5.57   0.00   6.30    0.0   55.7   0.0 650.9    0.0   68.5
## 612 Cirrhosis     0    64   0.0  24.0   0.0 102.8   0.0   2.9   0.0  44.4   0.0  20.0  0.00  1.54   0.00   3.02    0.0   63.0   0.0  35.9    0.0   71.3
## 613 Cirrhosis     0    64   0.0  29.0   0.0  87.3   0.0   3.5   0.0  99.0   0.0  48.0  0.00  1.66   0.00   3.63    0.0   66.7   0.0  64.2    0.0   82.0
## 614 Cirrhosis     0    46   0.0  33.0   0.0   0.0   0.0  39.0   0.0  62.0   0.0  20.0  0.00  3.56   0.00   4.20    0.0   52.0   0.0  50.0    0.0   71.0
## 615 Cirrhosis     0    59   0.0  36.0   0.0   0.0   0.0 100.0   0.0  80.0   0.0  12.0  0.00  9.07   0.00   5.30    0.0   67.0   0.0  34.0    0.0   68.0

SVM: Entrenamiento y predicción

Se divide el conjunto de datos en dos, uno para entrenar y otro para validar.

La división se hace aleatoriamente manteniendo la proporción de categorías en cada conjunto de manera que el 80% de los datos se destinará al entrenamiento y el 20% para la validación.

set.seed(7)
validationIndex <- caret::createDataPartition(hcvdat_fe$Category, p = 0.80, list = FALSE)

# 20% datos para validación
my_test  <- hcvdat_fe[-validationIndex,]
# 80% datos para entrenamiento
my_train <- hcvdat_fe[validationIndex,]

#' Transforma las categorías para distinguir entre infectados y no infectados
toHCV <- function(x){
  y <- plyr::revalue(x, c("Donor"="N", "Hepatitis"="Y", "Fibrosis"="Y", "Cirrhosis"="Y"))
  return(y)
}
hcv_test <- toHCV(my_test$Category)

Entrenamiento

library(e1071)
svm_model <- svm(formula = Category~.,
                 data = my_train,
                 kernel = "polynomial", 
                 cost = 10, 
                 scale = FALSE, 
                 type = "C-classification")

Predicción

svm_pred <- predict(svm_model, newdata = my_test)
hcv_svm <- toHCV(as.factor(svm_pred))

Validación

Por un lado, tenemos la confusión en cuanto a la detección de infección

table(hcv_test, hcv_svm)
##         hcv_svm
## hcv_test   N   Y
##        N 107   1
##        Y   3  11

Por otro lado, tenemos la matriz de confusión del avance de la enfermedad

table(my_test$Category, svm_pred)
##            svm_pred
##             Donor Hepatitis Fibrosis Cirrhosis
##   Donor       107         1        0         0
##   Hepatitis     1         3        0         0
##   Fibrosis      2         1        1         0
##   Cirrhosis     0         0        1         5

Precisión

Vamos a calcular la precisión de detección y acierto que tiene el modelo en cada categoría y el valor accuracy que es la media del porcentaje de acierto de cada categoría.

#' Retorna un data.frame donde se expone cada categoría con su porcentaje de deteción, su porcentaje de acierto y su porcenteje de cofusión (complementario al acierto)
precisionMatrix <- function(y_true, y_pred){
  rnames <- levels(as.factor(y_true))
  # Para cada categoría se calcula la relación de detección y se multiplica por 100
  detect <- mapply(function(x){return(100 * Recall(y_pred = y_pred, y_true = y_true, positive = x))}, rnames)
  # Para cada categoría se calcula la relación de acierto y se multiplica por 100
  success <- mapply(function(x){return(100 * Precision(y_pred = y_pred, y_true = y_true, positive = x))}, rnames)
  # Se calcula la confusión
  confusion <- mapply(function(x){return (100 -x)}, success)
  
  df <- cbind.data.frame(as.data.frame(detect), as.data.frame(success), as.data.frame(confusion))
  names(df) <- c("Detección", "Acierto", "Confusión")
  return (df)
}

svm_pm <- rbind(precisionMatrix(hcv_test,hcv_svm), precisionMatrix(my_test$Category, svm_pred))
svm_pm <- svm_pm[rownames(svm_pm)!="Donor",]
svm_pm
cat("Accuracy:", Accuracy(y_pred = svm_pred, y_true = my_test$Category))
## Accuracy: 0.9508197

Resultado con otros kernels

Radial basis

svm_model_rb <- svm(formula = Category~.,
                 data = my_train,
                 kernel = "radial", 
                 cost = 10, 
                 scale = FALSE, 
                 type = "C-classification")
svm_pred_rb <- predict(svm_model_rb, newdata = my_test)
cat("Accuracy:",
      MLmetrics::Accuracy(y_pred = svm_pred_rb, y_true = my_test$Category))
## Accuracy: 0.8852459

No mejora el resultado del kernel polinomial.

Sigmoid

svm_model_sig <- svm(formula = Category~.,
                 data = my_train,
                 kernel = "sigmoid", 
                 cost = 10, 
                 scale = FALSE, 
                 type = "C-classification")
svm_pred_sig <- predict(svm_model_sig, newdata = my_test)
cat("Accuracy:",
      MLmetrics::Accuracy(y_pred = svm_pred_sig, y_true = my_test$Category))
## Accuracy: 0.8852459

Tampoco mejora el resultado del kernel polinomial.

Ranger Forest: Entrenamiento y predicción

Se usarán los mismos datos de entrenamiento y validación que para el modelo SVM.

Entrenamiento

library(ranger)
ranger_model <- ranger(
              Category~.,
              data = my_train,
              num.trees = 100,
              importance = 'impurity',
              write.forest = TRUE,
              min.node.size = 1,
              splitrule = "gini",
              verbose = TRUE,
              classification = TRUE
            )

Predicción

ranger_pred <- predict(ranger_model, data = my_test)
hcv_ranger <- toHCV(as.factor(ranger_pred$predictions))

Validación

table(hcv_test, hcv_ranger)
##         hcv_ranger
## hcv_test   N   Y
##        N 107   1
##        Y   6   8
table(my_test$Category, ranger_pred$predictions)
##            
##             Donor Hepatitis Fibrosis Cirrhosis
##   Donor       107         0        0         1
##   Hepatitis     2         2        0         0
##   Fibrosis      4         0        0         0
##   Cirrhosis     0         0        1         5

Precisión

Usando la función precisionMatrix definida anteriormente, se calcula el porcentaje de detección y acierto del modelo. También se calcula el valor de accuracy.

ranger_pm <- rbind(precisionMatrix(hcv_test,hcv_ranger), precisionMatrix(my_test$Category, ranger_pred$predictions))
ranger_pm <- ranger_pm[rownames(ranger_pm)!="Donor",]
ranger_pm
cat("Accuracy:",
      MLmetrics::Accuracy(y_pred = ranger_pred$predictions, y_true = my_test$Category))
## Accuracy: 0.9344262

Conclusiones

Ambos modelos tienen una predicción muy alta de casos negativos de infección (107 de 108).

Los falsos negativos en el caso de SVM son 3 mientras que para el modelo Ranger Forest son 6. En este sentido podemos decir que predice mejor los casos negativos de HCV el modelo SVM.

Hay 14 casos de infección de los cuales el modelo SVM ha detectado 11 y se ha confundido en 1, mientras que el modelo Ranger Forest ha detectado 8 y se ha equivocado en 1. De aquí podemos deducir que el modelo SVM también es mejor para detectar los casos de infección por HCV.

Con los datos anteriores podemos considerar mejor el modelo SVM que el Ranger Forest.

Hemos visto que el modelo SVM tiene, para los casos de no infección una detección del 99% y una confusión del 2.8% y para los casos de infección una detección del 78.57% y una confusión del 8.33%.

Podemos decir que el modelo SVM es bueno para determinar la infección por el virus, aunque no lo es tanto para clasificar el grado de afección. En particular para los casos de Hepatitis (que de 5 predicciones se ha confundido en 2) y de Fibrosis (que sólo ha detectado 1 de 4).

Este modelo nunca podría ser determinante para diagnosticar, pero puede ser de gran utilidad para aquellos pacientes a los que se les realiza un análisis hepático de sangre y han tenido contacto sin saberlo con el virus HCV, así, si el modelo pronostica que el paciente tiene infección, se le deberían realizar las pruebas de detección.

Referencias

Dua, D. and Graff, C. (2019). UCI Machine Learning Repository [http://archive.ics.uci.edu/ml]. Irvine, CA: University of California, School of Information and Computer Science.

V. Aguilera y M. Berenguer (Servicio de Medicina Digestiva. Hospital Universitario La Fe. Valencia). Virus de la hepatitis C y fibrosis. Revista Española de Enfermedades Digestivas

Cigna. https://www.cigna.com/individuals-families/health-wellness/hw-en-espanol/pruebas-medicas/pruebas-del-virus-de-la-hepatitis-c-tw9921#:~:text=La%20prueba%20del%20virus%20de%20la%20hepatitis%20C%20(HCV)%20es,el%20cuerpo%20contra%20el%20HCV

María Blanco Arranz