## [1] "Sample" "GM.CFS" "IFNg" "IL17A" "IL1b" "IL23" "IL6" "TNFa"Table 1. All Matrices Summary Table
| C (n=9) |
E (n=25) |
L (n=9) |
L2 (n=4) |
Sep (n=9) |
Ser (n=16) |
Overall (n=72) |
|
|---|---|---|---|---|---|---|---|
| IL17A | |||||||
| Mean (SD) | 9.03 (12.3) | 7.97 (7.73) | 9.02 (14.1) | 7.65 (11.4) | 7.13 (8.70) | 9.58 (11.0) | 8.47 (10.0) |
| Median [Min, Max] | 4.53 [1.70, 41.2] | 5.52 [1.31, 29.7] | 5.36 [0.135, 45.8] | 2.17 [1.45, 24.8] | 3.11 [0.135, 29.1] | 5.50 [1.55, 38.4] | 5.16 [0.135, 45.8] |
| IL23 | |||||||
| Mean (SD) | 1110 (1560) | 657 (1080) | 1020 (1650) | 1510 (2510) | 764 (1130) | 1060 (1820) | 909 (1460) |
| Median [Min, Max] | 544 [212, 5190] | 327 [150, 5260] | 503 [3.45, 5340] | 298 [175, 5280] | 371 [3.45, 3700] | 501 [76.9, 7360] | 377 [3.45, 7360] |
| Missing | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (6.2%) | 1 (1.4%) |
| IL6 | |||||||
| Mean (SD) | 8.57 (8.96) | 11.4 (15.1) | 8.37 (8.47) | 7.39 (7.70) | 5.59 (5.57) | 10.4 (13.6) | 9.50 (12.0) |
| Median [Min, Max] | 3.62 [0.520, 26.5] | 4.00 [0.540, 55.6] | 6.23 [0.0350, 26.0] | 7.07 [0.0350, 15.4] | 2.28 [1.13, 17.7] | 4.70 [0.200, 54.6] | 3.86 [0.0350, 55.6] |
| TNFa | |||||||
| Mean (SD) | 8.56 (6.91) | 4.79 (4.54) | 8.05 (7.62) | 10.8 (9.69) | 6.80 (6.23) | 7.14 (7.12) | 6.78 (6.39) |
| Median [Min, Max] | 6.73 [2.18, 26.4] | 3.77 [2.15, 25.7] | 6.54 [1.48, 27.3] | 6.82 [4.39, 25.2] | 5.46 [0.610, 21.7] | 4.96 [2.40, 32.1] | 4.96 [0.610, 32.1] |
| GM.CFS | |||||||
| Mean (SD) | 56.0 (31.8) | 34.2 (23.4) | 47.8 (41.7) | 60.5 (31.3) | 41.1 (27.0) | 39.9 (30.3) | 42.2 (29.7) |
| Median [Min, Max] | 45.0 [15.6, 105] | 26.0 [9.37, 101] | 35.8 [2.82, 115] | 53.4 [31.1, 104] | 42.5 [0.570, 95.2] | 30.8 [12.0, 104] | 33.5 [0.570, 115] |
| IFNg | |||||||
| Mean (SD) | 19.6 (23.7) | 33.6 (32.0) | 18.1 (24.5) | 26.7 (35.2) | 15.4 (14.9) | 31.8 (34.2) | 26.6 (29.1) |
| Median [Min, Max] | 11.0 [5.31, 80.9] | 24.6 [6.35, 150] | 10.1 [0.0900, 80.0] | 12.2 [3.21, 79.0] | 13.3 [0.0900, 52.2] | 21.9 [6.58, 134] | 18.8 [0.0900, 150] |
| Missing | 0 (0%) | 2 (8.0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (6.2%) | 3 (4.2%) |
| IL1b | |||||||
| Mean (SD) | 3.93 (3.91) | 2.20 (2.39) | 3.35 (3.88) | 4.51 (3.24) | 2.87 (2.77) | 2.89 (2.93) | 2.93 (2.99) |
| Median [Min, Max] | 3.04 [1.42, 13.9] | 1.25 [0.700, 9.98] | 2.76 [0.200, 13.1] | 3.06 [2.57, 9.36] | 2.08 [0.200, 9.93] | 1.77 [0.570, 11.4] | 1.98 [0.200, 13.9] |
| Missing | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (6.2%) | 1 (1.4%) |
\(~\)
Table 2. Differences Between ETDA and Serum OVer all Timepoints (baseline, day 14 and day 21 for EDTA, and baseline and day 14 for Serum)
| E (n=25) |
Ser (n=16) |
P-value | |
|---|---|---|---|
| IL17A | |||
| Mean (SD) | 7.97 (7.73) | 9.58 (11.0) | 0.614 |
| Median [Min, Max] | 5.52 [1.31, 29.7] | 5.50 [1.55, 38.4] | |
| IL23 | |||
| Mean (SD) | 657 (1080) | 1060 (1820) | 0.44 |
| Median [Min, Max] | 327 [150, 5260] | 501 [76.9, 7360] | |
| Missing | 0 (0%) | 1 (6.2%) | |
| IL6 | |||
| Mean (SD) | 11.4 (15.1) | 10.4 (13.6) | 0.828 |
| Median [Min, Max] | 4.00 [0.540, 55.6] | 4.70 [0.200, 54.6] | |
| TNFa | |||
| Mean (SD) | 4.79 (4.54) | 7.14 (7.12) | 0.253 |
| Median [Min, Max] | 3.77 [2.15, 25.7] | 4.96 [2.40, 32.1] | |
| GM.CFS | |||
| Mean (SD) | 34.2 (23.4) | 39.9 (30.3) | 0.529 |
| Median [Min, Max] | 26.0 [9.37, 101] | 30.8 [12.0, 104] | |
| IFNg | |||
| Mean (SD) | 33.6 (32.0) | 31.8 (34.2) | 0.873 |
| Median [Min, Max] | 24.6 [6.35, 150] | 21.9 [6.58, 134] | |
| Missing | 2 (8.0%) | 1 (6.2%) | |
| IL1b | |||
| Mean (SD) | 2.20 (2.39) | 2.89 (2.93) | 0.449 |
| Median [Min, Max] | 1.25 [0.700, 9.98] | 1.77 [0.570, 11.4] | |
| Missing | 0 (0%) | 1 (6.2%) |
\(~\)
Table 3. Differences Between EDTA and Serum at Baseline
| E (n=9) |
Ser (n=9) |
P-value | |
|---|---|---|---|
| IL17A | |||
| Mean (SD) | 8.05 (8.84) | 10.1 (11.4) | 0.675 |
| Median [Min, Max] | 3.89 [1.31, 29.7] | 5.66 [1.82, 38.4] | |
| IL23 | |||
| Mean (SD) | 935 (1630) | 1350 (2280) | 0.666 |
| Median [Min, Max] | 431 [150, 5260] | 605 [215, 7360] | |
| IL6 | |||
| Mean (SD) | 7.69 (7.92) | 8.74 (8.22) | 0.785 |
| Median [Min, Max] | 5.04 [0.710, 25.5] | 5.81 [0.610, 26.1] | |
| TNFa | |||
| Mean (SD) | 7.35 (7.02) | 10.1 (8.46) | 0.46 |
| Median [Min, Max] | 5.20 [2.23, 25.7] | 8.28 [3.06, 32.1] | |
| GM.CFS | |||
| Mean (SD) | 50.6 (29.8) | 54.1 (33.2) | 0.821 |
| Median [Min, Max] | 37.7 [14.9, 101] | 36.9 [14.0, 104] | |
| IFNg | |||
| Mean (SD) | 20.8 (21.4) | 23.8 (24.5) | 0.786 |
| Median [Min, Max] | 12.0 [6.35, 73.7] | 13.1 [6.58, 83.2] | |
| IL1b | |||
| Mean (SD) | 2.97 (2.73) | 3.44 (3.15) | 0.742 |
| Median [Min, Max] | 2.37 [1.13, 9.98] | 2.43 [1.03, 11.4] |