The Central de Abastecimiento del Sistema Nacional de Servicios de Salud (Cenabast) is a public entity in Chile in charge of the procurement of medicines needed by the Ministry of Health and other public entities in the country. While they are the biggest buyer of medicines in Chile, public entities like hospitals can buy medicines directly.
One of the biggest problems in Chile is the high price of medicines. This has been reported by civil society organizations like Observatorio Fiscal, media outlets in the country and has been discussed in Congress and the Central Government.
To tackle this issue, different measures have been implemented in Chile aimed to increase Cenabast power to act as an intermediary to buy medicines at a lower price, for both the public sector and local pharmacies. The first measure took place in October 2019, and increased the number of medicines that Cenabast intermediates to 80% of the total value. This means that out of the total value procured in medicines by public entities, 80% has to be done by Cenabast and not individually. The second measure is the Ley Cenabast that came into effect on April 6, 2020, and allows local pharmacies in Chile to buy medicines directly to Cenabast. This way Cenabast can act as an intermediary for the private sector, using its market power to buy medicines at a lower price, which could then translate into big savings for the public in retail pharmacies.
The objective of this analysis is to evaluate if there has been a change in the price of medicines after the measures took place.
For this we use the following datasets:
Chile Compra OCDS dataset, that includes all open procedures from January 2018 to September 17 2020. We filter the procedures that awarded medicines, using the UNSPSC high level code 51 (Drugs and Pharmaceutical Products).
The Consumer Price index, to adjust prices by inflation.
Data cleaning considerations:
To compare a change in medicine prices it is necessary to compare the same drug forms (dosages, label, etc). While with the UNSPSC codes it is possible to classify medicines, for the same code, multiple drug forms are available. For instance UNSPSC code 51142001 refers to Acetaminophen, however as seen in Table 1, the drug forms can be very different:
| item_id | award_item_description | unit_name |
|---|---|---|
| 51142001 | paracetamol comprimido 80mg | Unidad |
| 51142001 | paracetamol infantil comprimidos 80 mg | Unidad |
| 51142001 | paracetamol gotas 100 Mg/ml (15ml) | Unidad |
| 51142001 | paracetamol cm 80-100 mg | Comprimido |
| 51142001 | paracetamol 500 mg cm/cm recubierto | Comprimido |
| 51142001 | paracetamol 80 - 100 mg/ml gotas, frasco de 15 a 25 ml | Frasco |
| 51142001 | paracetamol cm 80-100 mg | Comprimido |
| 51142001 | paracetamol 80 mg cm | Comprimido |
| 51142001 | paracetamol 100 mg/ml gotas, frasco de 15 a 25 ml | Frasco |
| 51142001 | paracetamol 80 mg cm | Comprimido |
However, medicines purchased by Cenabast include in their descripton the ZGEN code, that is different for each drug form (see table 2). Thus it is possible to compare changes in unit prices for Cenabast tenders but not for the other entities.
| item_id | award_item_description | unit_name |
|---|---|---|
| 51142001 | PARACETAMOL 10 MG/ML SOL.INY FAM 100ML (100002921) | Unidad |
| 51142001 | PARACETAMOL 10 MG/ML SOL.INY FAM/BOL 100002921 | Unidad |
| 51142001 | PARACETAMOL 1000 MG CM(100004069) | Unidad |
| 51142001 | PARACETAMOL 160 CM MASTICABLES (100002578) | Unidad |
| 51142001 | PARACETAMOL 500 MG CM/CM REC (100001143) | Unidad |
| 51142001 | PARACETAMOL 500 MG CM/CM REC (100001143) | Unidad |
| 51142001 | PARACETAMOL 500 MG CM/CM REC 100001143 | Unidad |
| 51142001 | PARACETAMOL 500 MG CM/CM REC(100001143) | Unidad |
From 2018 to September 2020, there were 1243 different open procedures in Cenabast buying medicines. While the number of procedures was similar in 2018 and 2019, the total value (constant) procured in medicines was 2.5 times higher in 2019. Up to September 17 2020, the total value awarded was 96.5% of the total 2019 value.
805 different medicines were procured with 127 unique suppliers. The number of unique tenderers for these medicines was of 159 .
The unique medicines bought is not the same each year. In 2018 32% of the medicines were only purchased that year, in 2019 35% of the items were bought only in that period an in 2020 the proportion is of 54%. As Cenabast explained, the Canasta Esencial de medicamentos (that includes the items Cenabst expects to buy in a particular period) is dinamic and can change during the year.
Regarding competition, while there was a decrease in single bid tenders in 2019, from 31.1% in 2018 to 21.1% in 2019, in 2020 the proportion increased to 47.7%.
75% of the items that received a single bid in 2020 have only been procured this year, so it is not possible to know if for these medicines there is a single supplier in the market. This could be a result of emergency purchases related to the Covid-19 emergency.
| multiple years | only 2020 | |
|---|---|---|
| 2 to 3 bids | 61.5 | 38.5 |
| 4 or more bids | 69.8 | 30.2 |
| single bid | 25.1 | 74.9 |
We segment the awards in two periods: those awarded before January 2020 and those awarded after. In total, Cenabast procured 805 between 2018 an September 2020. Out of those medicines, 168 were bought in both periods, 200 only in 2020 and only 437 before. Our analysis focuses on 387 procedures procuring 168 unique medicines bought in both periods.
Most of the medicines were bought only once in each period. As Cenabast explained, contracts for are normally for 12 months or 18 months (at the end of 2018 there was a change in the regulation).
Comparing both periods, out of the 168 medicines analysed, 58.9 % saw a decrease in the average real price in 2020 and 40.5% had a price increase (Note: This reflects price differences before and after, but not necessarily the effect of new regulations on prices).
The price decreases range from -79.1% to -0.8%, with a average price reduction of -21.8%. For the medicines that incresed the price, the average price increase was of 19.9%, and ranges from 1% to 111.9% (this purchase corresponds to a purchase of metformina).
Below there is a list of the 10 medicines with the highest price reductions:
| zgen | description | Price change | change_quantity | change_tenderers | suppliers_After 2020 | suppliers_Before 2020 |
|---|---|---|---|---|---|---|
| 100003753 | FINGOLIMOD 0,5 MG CP (100003753) | -79.1 | increase | increase | Alpha Pharma Chile | Alpha Pharma Chile | Ascend Laboratories SpA | Ascend Laboratories SpA |
| 100003428 | BORTEZOMIB 3,5 MG POLVO LIOF. FAM 100003428 | -78.9 | increase | decrease | LKM Chile SpA | LKM Chile | NOVARTIS CHILE S A | NOVARTIS CHILE S A - Recben | Recben Xenerics Farmaceutica |
| 100004700 | ABIRATERONA 250 MG CM/CM REC(100004700) | -64.1 | increase | no change | Alpha Pharma Chile | Alpha Pharma Chile | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA |
| 100003230 | DONEPEZILO 10 MG CM REC/CM DISPERSABLE (100003230) | -62.6 | increase | decrease | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | Alpha Pharma Chile | Alpha Pharma Chile |
| 100002048 | LINEZOLID 600 MG CM REC(100002048) | -62 | decrease | decrease | Ascend Laboratories SpA | Ascend Laboratories SpA | WINPHARM SPA | WINPHARM - Edison Alejandro | Edison Alejandro - NOVARTIS CHILE S A | NOVARTIS CHILE S A |
| 100003895 | MUPIROCINA 2% UNG. DERMICO TUBO/POMO(100003895) | -48.2 | increase | decrease | SOCOFAR S A | Socofar Division Munnich | Laboratorios Lafi | Market Access |
| 100002921 | PARACETAMOL 10 MG/ML SOL.INY FAM/BOL 100002921 | -47.6 | increase | increase | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | Fresenius Kabi Chile Ltda. | Fresenius Kabi Chile Ltda. |
| 100002075 | MILRINONA 1MG/ML SOL INYECTABLE AM/FAM(100002075) | -46.3 | increase | increase | BPH S.A | BPH S.A | Libra Chile S.A. | Libra Chile S.A. |
| 100001431 | TENOFOVIR DISOPROXIL 300 MG CM REC 100001431 | -44.2 | decrease | decrease | Gador Limitada | GADOR LIMITADA | Seven Pharma Chile | Seven Pharma Chile - Ascend Laboratories SpA | Ascend Laboratories SpA |
| 100002255 | ONDANSETRON 4 MG CM/CM REC/CM DISPER (100002255) | -43.9 | increase | increase | REUTTER S.A | REUTTER DIVISION MEDICA | NOVARTIS CHILE S A | NOVARTIS CHILE S A - Laboratorio Pasteur SA | Laboratorio Pasteur SA |
Regarding the quantity, the volume of the purchases increased for 87.5% of the medicines. On average, the quantity increased 173.1% or (2.7 times). This increase in the volume, could be a result of a change in the regulations after 2018, to buy for an 18 month period instead of a 12 month period.
The plot below illustrates that a higher quantity did not necessarily translate into lower prices, since 80.9% of medicines that increased their price, also increased their quantity.
| Change in quantity | Total |
|---|---|
| decrease | 12.5 |
| increase | 87.5 |
In terms of the number of tenderers and the suppliers, 31% of the medicines increased the number of tenderers. For the medicines with a price decrease, 40.4% increased the number of tenderers.
Regarding the suppliers, 56.5% of the medicines had at least two suppliers and 11.9% had 3 or 4, meaning they changed suppliers during the period. Only 23% of the medicines with a price decrease has a single supplier, in comparisson to 43% of those that incresed their price.
87 suppliers were awarded contracts in both periods. 17 of the 60 suppliers awarded in 2020, hadn’t won a contract for those medicines previously.
How did the distribution of the contracts by suppliers changed?
Roche Chile Ltda. Roche Pharma concentrated most of the value awarded with 8.1% of the total value. In 2020, its share of the market decreased to 3.9%, procuring the same medicine for a lower real price (the nominal price remained the same).OPKO CHILE S.A. concentrated 14.3% of the total value awarded, selling 7 different medicines. Before the company concentrated 0.2% of the value, for the analyzed medicines.The full tables of medicines analyzed with their changes in prices, quantities and suppliers can be found below:
| zgen | description | change_price | Price change % | change_quantity | change_tenderers | suppliers_After 2020 | suppliers_Before 2020 | unique_suppliers | change_quantity_percentage | change_tenderers_number |
|---|---|---|---|---|---|---|---|---|---|---|
| 100000013 | ACICLOVIR 400 MG CM (100000013) | increase | 22 | increase | no change | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Alpha Pharma Chile | Alpha Pharma Chile | 2 | 118.7 | 0 |
| 100000030 | ACIDO URSODEOXICOLICO 250MG CP/CM/CM REC(100000030) | decrease | -7.2 | decrease | decrease | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | FARMA STORAGE | FARMA STORAGE - Grunenthal Chilena | Grunenthal Chilena - Casa Matriz - Laboratorios Lafi | Market Access | 3 | -97.5 | -1 |
| 100000033 | ACIDO VALPROICO 250 MG CP/CM REC. 100000033 | increase | 5.4 | increase | decrease | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. | 2 | 134.7 | -2 |
| 100000045 | AGUA ESTERIL P/INYECTABLES 5 ML AM (100000045) | increase | 1.9 | increase | increase | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | IMPROFAR | IMPROFAR | 2 | 70.3 | 1 |
| 100000100 | ALOPURINOL 100 MG CM 100000100 | decrease | -35.4 | increase | no change | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | 1 | 104.5 | 0 |
| 100000104 | ALPROSTADIL 500 MCG/1 ML SOL.INY. AM/FAM(100000104) | decrease | -33.7 | increase | increase | Diprovet SPA | Diprovet | LABORATORIOS WYETH LLC | LABORATORIOS WYETH LLC - LABORATORIOS WYETH LLC | LABORATORIOS WYETH LLC | 2 | 224.7 | 2 |
| 100000114 | AMINOACIDOS ESENCIAL 10%SOL IV FAM 500ML (100000114) | decrease | -4.6 | increase | increase | Fresenius Kabi Chile Ltda. | Fresenius Kabi Chile Ltda. | Fresenius Kabi Chile Ltda. | Fresenius Kabi Chile Ltda. | 1 | 29.4 | 1 |
| 100000118 | AMIODARONA 150 MG/3 ML SOL. INY. AM/FAM(100000118) | decrease | -1.1 | increase | no change | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | 1 | 77.1 | 0 |
| 100000169 | ATRACURIO BESIL 25MG/2,5ML SOL.INYAM/FAM(100000169) | increase | 14.9 | increase | decrease | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. - LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 2 | 79.6 | -1 |
| 100000171 | ATROPINA 1% SOL. OFTALM. FRA 5 A 10 ML(100000171) | increase | 4.1 | increase | no change | BPH S.A | BPH S.A | BPH S.A | BPH S.A | 1 | 179.2 | 0 |
| 100000176 | AZITROMICINA 500 MG CP/CM/CM REC. 100000176 | increase | 37.8 | increase | decrease | Ascend Laboratories SpA | Ascend Laboratories SpA | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables - Pharma Network SpA | Pharma Network SpA | 3 | 52.1 | -1 |
| 100000177 | BACLOFENO 10 MG CM (100000177) | decrease | -30.7 | increase | increase | PHARMAMERICA LTDA. | PHARMAMERICA LTDA. | PHARMAMERICA LTDA. | PHARMAMERICA LTDA. - INVERSIONES PHARMAVISAN S.A | INVERSIONES PHARMAVISAN S.A. | 2 | 216.2 | 1 |
| 100000236 | BROMHEXINA 4 MG/5ML JARAB FRA 100A120 ML(100000236) | decrease | -3.5 | increase | increase | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | OPKO CHILE S.A. | OPKO CHILE S.A. - GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | 3 | 14.5 | 1 |
| 100000275 | CALCIO CARBONATO 1250 MG CM/CM REC/MAST(100000275) | decrease | -8.9 | increase | no change | ZERICUM | ZERICUM | HOSPIFARMA CHILE LIMITADA | HOSPIFARMA | 2 | 194.9 | 0 |
| 100000358 | CEFTRIAXONA 1G POLVO SOL.INY I.M/I.V.FAM (100000358) | increase | 4.9 | increase | no change | MEDBIOTEC | MEDBIOTEC | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | 2 | 100.9 | 0 |
| 100000366 | CETIRIZINA 10 MG CP/CM/CM REC.(100000366) | decrease | -30.4 | increase | decrease | Ascend Laboratories SpA | Ascend Laboratories SpA | MEDIPHARM S.A. | MEDIPHARM S.A. | 2 | 98.9 | -2 |
| 100000379 | CIPROFLOXACIN 200MG/100ML SOL INY FAM/BO (100000379) | increase | 12.9 | increase | increase | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | 1 | 105.2 | 1 |
| 100000388 | CLINDAMICINA 600 MG/4 ML SOL.INY. AM/FAM(100000388) | increase | 19.2 | increase | decrease | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | Labvitalis | Labvitalis | 2 | 66.5 | -1 |
| 100000391 | CLOMIPRAMINA 75 MG CM REC. LIB. PROLONG.(100000391) | decrease | -30.3 | increase | increase | PHARMATRADE S.A | 966706406 | NOVARTIS CHILE S A | NOVARTIS CHILE S A | 2 | 148.2 | 1 |
| 100000486 | DANTROLENO 20 MG POLV/LIOF SOL INYEC.FAM(100000486) | increase | 15.1 | decrease | no change | DROGUERIA FARMOQUIMICA DEL PACIFICO LTDA | DROGUERIA FARMOQUIMICA DEL PACIFICO LTDA | DROGUERIA FARMOQUIMICA DEL PACIFICO LTDA | DROGUERIA FARMOQUIMICA DEL PACIFICO LTDA | 1 | -9.4 | 0 |
| 100000506 | DICLOFENACO SODICO 50MG CM REC.ENTERICO(100000506) | increase | 6.3 | increase | decrease | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | 1 | 6.0 | -1 |
| 100000528 | DOXAZOSINA 4 MG CM/CM REC (100000528) | decrease | -21.5 | increase | increase | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | PHARMATRADE S.A | 966706406 | 2 | 48.4 | 1 |
| 100000547 | ENALAPRIL 10 MG CM/CM REC(100000547) | decrease | -9.1 | increase | increase | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables - LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. | 3 | 18.1 | 1 |
| 100000593 | ESTREPTOQUINASA 1.500.000 U.I. LIOF FAM 100000593 | increase | 31 | increase | increase | Luxypharm SpA | Luxypharm | Luxypharm SpA | Luxypharm | 1 | 70.3 | 2 |
| 100000600 | ETOMIDATO 2MG/ML SOL. INY. AM/FAM 10 ML(100000600) | increase | 14.9 | increase | no change | Pisa Farmaceutica de Chile SpA | Pisa Farmaceutica de Chile SpA | Pisa Farmaceutica de Chile SpA | Pisa Farmaceutica de Chile SpA - Pisa Farmaceutica de Chile SpA | Pisa Farmaceutica de Chile SpA | 1 | 42.6 | 0 |
| 100000623 | FENOBARBITAL 15 MG CM(100000623) | increase | 9.1 | increase | no change | BPH S.A | BPH S.A | BPH S.A | BPH S.A | 1 | 7.8 | 0 |
| 100000629 | FENTANILO 0,5 MG/10 ML SOL. INY. AM/FAM 100000629 | decrease | -8.3 | increase | increase | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. - LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 1 | 67.7 | 2 |
| 100000721 | GLUCOSA 5% ENV. SEMIRIGIDO 250 ML(100000721) | increase | 7.7 | increase | increase | B.BRAUN MEDICAL SpA2 | B.BRAUN MEDICAL SpA | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 2 | 138.0 | 1 |
| 100000725 | GLUCOSA 5% ENV. SEMIRIGIDO 1 L(100000725) | increase | 16.4 | increase | increase | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. - LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. - LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 1 | 144.8 | 1 |
| 100000726 | GLUCOSA 5% BOLSA 1 L (100000726) | increase | 10.5 | increase | decrease | BAXTER CHILE LTDA. | BAXTER CHILE LTDA. | BAXTER CHILE LTDA. | BAXTER CHILE LTDA. | 1 | 98.2 | -2 |
| 100000764 | HALOPERIDOL 1 MG CM (100000764) | increase | 1 | decrease | increase | WINPHARM SPA | WINPHARM | WINPHARM SPA | WINPHARM | 1 | -13.0 | 1 |
| 100000766 | HEPARINA SODICA 25.000 U.I./5 ML FAM/JRP(100000766 ) | increase | 83 | increase | decrease | Ascend Laboratories SpA | Ascend Laboratories SpA | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 2 | 107.9 | -2 |
| 100000768 | HIDROCLOROTIAZ./TRIAMTERENO 25/50 MG CM(100000768) | increase | 10.3 | decrease | no change | ITF Farma Chile | ITF Labomed Farmaceutica Limitada | ITF Farma Chile | ITF Labomed Farmaceutica Limitada | 1 | -31.7 | 0 |
| 100000772 | HIDROCORTISONA 100MG LIOF. P/SOL INY FAM(100000772) | increase | 10 | increase | decrease | OPKO CHILE S.A. | OPKO CHILE S.A. | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | 2 | 132.6 | -2 |
| 100000803 | IBUPROFENO 200 MG/5 ML FRA 100 A 120ML(100000803) | increase | 6.3 | increase | decrease | LABOFAR | LABOFAR | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA - HOSPIFARMA CHILE LIMITADA | HOSPIFARMA | 3 | 73.5 | -1 |
| 100000811 | IMIPRAMINA 25MG CM/CM REC/GG/CP(100000811) | decrease | -18.5 | increase | increase | BPH S.A | BPH S.A | BPH S.A | BPH S.A | 1 | 24.4 | 2 |
| 100000812 | INDOMETACINA 25 MG CM/CP (100000812) | increase | 40.2 | increase | decrease | Instituto Sanitas S.A. | Instituto Sanitas S.A. | Instituto Sanitas S.A. | Instituto Sanitas S.A. | 1 | 7.6 | -2 |
| 100000836 | ISOSORBIDE DINITRATO 10 MG CM/CM REC (100000836) | decrease | -33.1 | increase | no change | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | SOCOFAR S A | Socofar Division Munnich - FARMA STORAGE | FARMA STORAGE | 3 | 37.7 | 0 |
| 100000900 | LAMOTRIGINA 50 MG CM/CM REC/MAST/DISPE 100000900 | decrease | -17.7 | increase | decrease | INTERPHARMA | INTERPHARMA | FARMA STORAGE | FARMA STORAGE | 2 | 252.7 | -2 |
| 100000903 | LEVODOPA/BENSERAZIDA 200/50 MG CM(100000903) | decrease | -3.5 | increase | no change | Roche Chile Ltda. Roche Pharma | Roche Chile Ltda. Roche Pharma | Roche Chile Ltda. Roche Pharma | Roche Chile Ltda. Roche Pharma - Roche Chile Ltda. Roche Pharma | Roche Chile Ltda. Roche Pharma | 1 | 15.5 | 0 |
| 100000910 | LEVODOPA CARBIDOPA 250/25MG CM (100000910) | increase | 16 | increase | increase | PHARMATRADE S.A | 966706406 | LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. | 2 | 77.1 | 2 |
| 100000921 | LIDOCAINA 2% C/EPINEF. 1:100000 SOL.INY(100000921) | decrease | -7.5 | increase | no change | BUHOS S.C.I. LTDA. | BUHOS S.C.I. LTDA. | INMED DROGUERIA LTDA. | INMED DROGUERIA LTDA. | 2 | 51.2 | 0 |
| 100000963 | LEVOTIROXINA 25 MCG CM(100000963) | decrease | -4.6 | increase | no change | Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos | Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos | 1 | 76.1 | 0 |
| 100000964 | LEVOTIROXINA 100 MCG COMPRIMIDO RANURADO ENVASADO EN BLISTER. ENVASE RESISTENTE CON SELLO QUE ASEGURE LA INVIOLABILIDAD DEL CONTENIDO.COTIZAR POR COMPRIMIDO.100000964 | decrease | -0.9 | increase | no change | Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos | Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos - Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos | 1 | 60.3 | 0 |
| 100001014 | MERCAPTOPURINA 50 MG CM 100001014 | decrease | -27.8 | decrease | no change | BPH S.A | BPH S.A | BPH S.A | BPH S.A - Luxypharm SpA | Luxypharm | 2 | -7.0 | 0 |
| 100001018 | METADONA 10 MG/2ML SOL.INY. IV-SC AM/FAM(100001018) | decrease | -13 | increase | decrease | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. - Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | 2 | 113.5 | -1 |
| 100001026 | METILPREDNISOLONA ACETATO FAM 40 MG/ML 100001026 | decrease | -3.2 | increase | no change | LABORATORIOS WYETH LLC | LABORATORIOS WYETH LLC | PFIZER CHILE S.A. | PFIZER CHILE S.A. - PFIZER CHILE S.A. | PFIZER CHILE S.A. | 2 | 204.9 | 0 |
| 100001030 | METILPREDNISOLONA 40MG LIOF IV-IM FAM(100001030) | increase | 3.7 | increase | no change | LABORATORIOS WYETH LLC | LABORATORIOS WYETH LLC | PFIZER CHILE S.A. | PFIZER CHILE S.A. | 2 | 90.8 | 0 |
| 100001033 | METOCLOPRAMIDA 10 MG/2 ML SOL. INY. AM(100001033) | decrease | -23 | increase | increase | BPH S.A | BPH S.A | Luxypharm SpA | Luxypharm | 2 | 81.6 | 1 |
| 100001034 | METOCLOPRAMIDA 10 MG CM/CP(100001034) | decrease | -4.3 | increase | decrease | PHARMATRADE S.A | 966706406 | WINPHARM SPA | WINPHARM | 2 | 2.1 | -1 |
| 100001053 | MORFINA 20MG/ML SOL. INY. AM(100001053) | increase | 4.9 | increase | increase | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. - Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | 2 | 50.9 | 1 |
| 100001055 | MORFINA 30 MG CP/CM REC LIB PROLONGADA (100001055) | increase | 4.4 | increase | no change | QUALITEC FARMACÉUTICA LTDA. | Qualytec medicamentos | BPH S.A | BPH S.A | 2 | 91.5 | 0 |
| 100001079 | NISTATINA 100.000 UI/ML FRA 20 A 30 ML (100001079) | increase | 4.7 | increase | no change | BPH S.A | BPH S.A | BPH S.A | BPH S.A | 1 | 101.0 | 0 |
| 100001091 | NOREPINEFRINA 4MG/4 ML AM O FAM(100001091) | increase | 42.8 | decrease | no change | BPH S.A | BPH S.A | BPH S.A | BPH S.A | 1 | -13.6 | 0 |
| 100001104 | ONDANSETRON 8 MG CM/CM REC/CM DISPER (100001104) | decrease | -17.2 | increase | decrease | GALENICUM CHILE | GALENICUM CHILE | NOVARTIS CHILE S A | NOVARTIS CHILE S A | 2 | 174.6 | -1 |
| 100001107 | OSELTAMIVIR 12 MG/ML FRA 70 A 75 ML (100001107) | increase | 1.6 | increase | no change | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | FARMA STORAGE | FARMA STORAGE | 2 | 81.0 | 0 |
| 100001138 | PARAC/PSEUDOEF/CLORF 125/30/2MG/5 ML FRA(100001138) | decrease | -4.6 | increase | increase | Chemopharma S.A. | Chemopharma S.A. | Chemopharma S.A. | Chemopharma S.A. | 1 | 5.1 | 1 |
| 100001139 | PARACET/PSEUDOEF/CLORF 500/60/4 MG CM (100001139) | increase | 13.6 | increase | no change | Instituto Sanitas S.A. | Instituto Sanitas S.A. | Chemopharma S.A. | Chemopharma S.A. | 2 | 4.0 | 0 |
| 100001143 | PARACETAMOL 500 MG CM/CM REC(100001143) | decrease | -1.8 | increase | decrease | OPKO CHILE S.A. | OPKO CHILE S.A. | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables - LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. | 3 | 177.7 | -1 |
| 100001183 | PIRIDOSTIGMINA 60 MG CM O GG(100001183) | increase | 12.7 | increase | no change | PHARMAMERICA LTDA. | PHARMAMERICA LTDA. | PHARMAMERICA LTDA. | PHARMAMERICA LTDA. | 1 | 115.9 | 0 |
| 100001212 | PRIMIDONA 250 MG CM 100001212 | decrease | -2.4 | increase | no change | PHARMATRADE S.A | 966706406 | PHARMATRADE S.A | 966706406 | 1 | 86.6 | 0 |
| 100001218 | PROPARACAINA 5 MG/ML SOL OFT FRA 10A15ML 100001218 | decrease | -10.1 | increase | increase | ALCON LABORATORIOS CHILE LTDA | ALCON LABORATORIOS CHILE LTDA - Alcon Chile Farmacéutico | NOVARTIS CHILE S A | NOVARTIS CHILE S A - ALCON LABORATORIOS CHILE LTDA | ALCON LABORATORIOS CHILE LTDA - Alcon Chile Farmacéutico | 2 | 52.0 | 1 |
| 100001272 | SALES REHIDRATACION ORAL 90 MEQ/L SO(100001272) | increase | 27.2 | increase | increase | OPKO CHILE S.A. | OPKO CHILE S.A. | LABORATORIO VALMA S.A | LABORATORIO VALMA S.A - LABORATORIOS RAFFO S.A | LABORATORIOS RAFFO S.A | 3 | 121.6 | 1 |
| 100001299 | SODIO BICARBONATO 8,4% AM 10 ML(100001299) | increase | 1.5 | increase | no change | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 1 | 122.2 | 0 |
| 100001308 | SODIO CLORURO 0,9% BOLSA 500 ML 100001308 | increase | 4.6 | increase | decrease | BAXTER CHILE LTDA. | BAXTER CHILE LTDA. | BAXTER CHILE LTDA. | BAXTER CHILE LTDA. | 1 | 68.6 | -2 |
| 100001313 | RINGER LACTATO ENV. SEMIRIGIDO 500 ML (100001313) | decrease | -8.6 | increase | no change | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 1 | 55.4 | 0 |
| 100001369 | SULFASALAZINA 500 MG CM RECUB ENTERICO(100001369) | increase | 86.2 | increase | decrease | BPH S.A | BPH S.A | COMERCIAL RM SPA | COMERCIAL RM SPA - BPH S.A | BPH S.A | 2 | 93.8 | -1 |
| 100001408 | TACROLIMUS 1 MG CP 100001408 | decrease | -17.4 | increase | increase | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Pharma Network SpA | Pharma Network SpA | 2 | 41.2 | 2 |
| 100001431 | TENOFOVIR DISOPROXIL 300 MG CM REC 100001431 | decrease | -44.2 | decrease | decrease | Gador Limitada | GADOR LIMITADA | Seven Pharma Chile | Seven Pharma Chile - Ascend Laboratories SpA | Ascend Laboratories SpA | 3 | -85.5 | -2 |
| 100001435 | TESTOSTERONA ENANTATO 250 MG/ML AM/FAM (100001435) | decrease | -26.1 | increase | no change | ETHON PHARMACEUTICALS SPA. | ETHON PHARMACEUTICALS SPA. | ETHON PHARMACEUTICALS SPA. | ETHON PHARMACEUTICALS SPA. | 1 | 192.0 | 0 |
| 100001445 | TIOGUANINA 40 MG CM 100001445 | increase | 4.2 | decrease | no change | PHARMATECH CHILE SOCIEDAD ANÓNIMA | PHARMATECH | PHARMATECH CHILE SOCIEDAD ANÓNIMA | PHARMATECH | 1 | -29.2 | 0 |
| 100001465 | TRAMADOL 50 MG CP/CM REC(100001465) | decrease | -5.8 | decrease | increase | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Chemopharma S.A. | Chemopharma S.A. | 2 | -33.2 | 2 |
| 100001466 | TRAMADOL 100MG CM REC/CP LIBER.PROLONG(100001466) | decrease | -35.5 | increase | decrease | BPH S.A | BPH S.A | ITF Farma Chile | ITF Labomed Farmaceutica Limitada - Luxypharm SpA | Luxypharm | 3 | 110.0 | -2 |
| 100001467 | TRAMADOL 150MG CM REC/CP LIBER. PROLONG (100001467) | decrease | -43.3 | increase | increase | BPH S.A | BPH S.A | LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. - Luxypharm SpA | Luxypharm | 3 | 182.7 | 1 |
| 100001470 | TRAZODONA 100 MG CM/CM REC (100001470) | increase | 11.3 | increase | increase | PHARMATRADE S.A | 966706406 | LABORATORIO CHILE S.A. | LABORATORIO CHILE S.A. | 2 | 56.5 | 1 |
| 100001568 | VINCRISTINA 1MG/ML SOL. INYECT I.V. FAM(100001568) | increase | 34.2 | increase | no change | BPH S.A | BPH S.A | Luxypharm SpA | Luxypharm | 2 | 65.6 | 0 |
| 100001569 | VIT.B1/B6/B12 100MG/100MG/10MG AM(100001569) | increase | 13.7 | increase | no change | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. - Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | 1 | 45.6 | 0 |
| 100001575 | ZIDOVUDINA 300 MG CM REC (100001575) | increase | 19.3 | decrease | no change | Alpha Pharma Chile | Alpha Pharma Chile | Seven Pharma Chile | Seven Pharma Chile | 2 | -86.9 | 0 |
| 100001580 | ZOPICLONA 7,5 MG CM/CM REC.(100001580) | decrease | -13.1 | increase | no change | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Chemopharma S.A. | Chemopharma S.A. - GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | 2 | 72.2 | 0 |
| 100001701 | LEVONORGESTREL 1,5MG (ó 2X0,75 MG) DOSIS (100001701) | decrease | -31.3 | increase | no change | Exeltis SpA | Exeltis SpA | NOVOFARMA SERVICE S A | NOVOFARMA - EXELTIS | 2 | 132.6 | 0 |
| 100001912 | CLOBETASOL 0,05% CREMA DERMICA X GRAMO(100001912) | decrease | -28.8 | increase | increase | Ascend Laboratories SpA | Ascend Laboratories SpA | HOSPIFARMA CHILE LIMITADA | HOSPIFARMA | 2 | 927.7 | 3 |
| 100001915 | SOMATROPINA HUM. RECOMB 15 O 16 UI x UI (100001915) | increase | 44 | decrease | no change | NOVARTIS CHILE S A | NOVARTIS CHILE S A | PFIZER CHILE S.A. | PFIZER CHILE S.A. | 2 | -48.2 | 0 |
| 100001933 | SULPIRIDA 50 MG CP(100001933) | decrease | -25.5 | increase | increase | SOCOFAR S A | SOCOFAR S A | ITF Farma Chile | ITF Labomed Farmaceutica Limitada | 2 | 103.9 | 1 |
| 100001970 | INSULINA ULTRA RAPIDA 100 UI/ML FAM/CGE(100001970) | increase | 14.8 | decrease | decrease | Novo Nordisk Farmaceutica Limitada | Novo Nordisk Farmaceutica Limitada | SANOFI AVENTIS | SANOFI AVENTIS | 2 | -15.9 | -1 |
| 100002001 | AMOXIC/CLAVUL 400/57MG/5ML FRA 50/100ML(100002001) | increase | 14.1 | increase | decrease | MEDBIOTEC | MEDBIOTEC | Pharma Network SpA | Pharma Network SpA | 2 | 102.1 | -3 |
| 100002004 | CARVEDILOL 6,25 MG CM/CM REC.(100002004) | decrease | -15.3 | decrease | decrease | PHARMATRADE S.A | 966706406 | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A - Laboratorios Lafi | Market Access | 3 | -61.0 | -4 |
| 100002007 | CLORHEXIDINA 0,12% COLUTO FRA 100-150ML (100002007) | decrease | -4.9 | increase | no change | Trema | Trema | LABORATORIOS DENTAID S A | LABORATORIOS DENTAID S A | 2 | 117.9 | 0 |
| 100002015 | MELOXICAM 15 MG CM/CM REC/CM BUCODISPERS 100002015 | decrease | -17.1 | increase | increase | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | 1 | 63.1 | 1 |
| 100002027 | CARVEDILOL 12,5 MG CM/CM REC.(100002027) | increase | 8.9 | increase | decrease | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A - Laboratorios Lafi | Market Access - DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | 2 | 103.7 | -3 |
| 100002044 | FENTANILO 50MCG/HORA PARCHE TRANSDERMICO(100002044) | increase | 26.4 | increase | no change | Johnson & Johnson Medical | 2 Janssen-Cilag Chile | Johnson & Johnson Medical | 2 Janssen-Cilag Chile | 1 | 101.7 | 0 |
| 100002047 | IMATINIB 400 MG CP/CM REC.(100002047 ) | increase | 5.5 | decrease | decrease | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | 1 | -94.1 | -4 |
| 100002048 | LINEZOLID 600 MG CM REC(100002048) | decrease | -62 | decrease | decrease | Ascend Laboratories SpA | Ascend Laboratories SpA | WINPHARM SPA | WINPHARM - Edison Alejandro | Edison Alejandro - NOVARTIS CHILE S A | NOVARTIS CHILE S A | 4 | -63.7 | -2 |
| 100002049 | LINEZOLID 600MG/300ML SOLUC. INY. IV(100002049) | decrease | -14.7 | increase | increase | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | Recben | Recben Xenerics Farmaceutica | 2 | 274.5 | 1 |
| 100002053 | MICOFENOLATO 180 MG CM REC. ENTERICO (100002053) | decrease | -39.6 | increase | increase | QUALITEC FARMACÉUTICA LTDA. | Qualytec medicamentos | NOVARTIS CHILE S A | NOVARTIS CHILE S A - NOVARTIS CHILE S A | NOVARTIS CHILE S A | 2 | 49.3 | 1 |
| 100002054 | MICOFENOLATO 360 MG CM REC. ENTERICO(100002054) | decrease | -40.3 | increase | increase | QUALITEC FARMACÉUTICA LTDA. | Qualytec medicamentos | NOVARTIS CHILE S A | NOVARTIS CHILE S A | 2 | 79.1 | 1 |
| 100002070 | LEVETIRACETAM 1000 MG CM REC 100002070 | no change | 0 | increase | decrease | Alpha Pharma Chile | Alpha Pharma Chile | Seven Pharma Chile | Seven Pharma Chile | 2 | 93.8 | -2 |
| 100002074 | ATORVASTATINA 40 MG CM REC.(100002074) | decrease | -19.2 | increase | no change | PHARMATRADE S.A | 966706406 | Pharma Network SpA | Pharma Network SpA | 2 | 127.7 | 0 |
| 100002075 | MILRINONA 1MG/ML SOL INYECTABLE AM/FAM(100002075) | decrease | -46.3 | increase | increase | BPH S.A | BPH S.A | Libra Chile S.A. | Libra Chile S.A. | 2 | 206.3 | 3 |
| 100002100 | ENTECAVIR 0,5 MG CM REC(100002100) | decrease | -27.3 | increase | no change | Geamed S.A. | Geamed S.A. | Seven Pharma Chile | Seven Pharma Chile - Seven Pharma Chile | Seven Pharma Chile | 2 | 12.1 | 0 |
| 100002224 | ENTECAVIR 1 MG CM REC (100002224) | increase | 29.5 | decrease | decrease | Alpha Pharma Chile | Alpha Pharma Chile | Seven Pharma Chile | Seven Pharma Chile | 2 | -3.2 | -2 |
| 100002255 | ONDANSETRON 4 MG CM/CM REC/CM DISPER (100002255) | decrease | -43.9 | increase | increase | REUTTER S.A | REUTTER DIVISION MEDICA | NOVARTIS CHILE S A | NOVARTIS CHILE S A - Laboratorio Pasteur SA | Laboratorio Pasteur SA | 3 | 104.3 | 2 |
| 100002261 | PREGABALINA 150 MG CM/CP 100002261 | decrease | -38 | increase | increase | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | NOVARTIS CHILE S A | NOVARTIS CHILE S A - NOVARTIS CHILE S A | NOVARTIS CHILE S A | 2 | 238.6 | 3 |
| 100002264 | SERTRALINA 100 MG CM/CM REC/CP(100002264) | decrease | -7.1 | increase | no change | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Laboratorios Lafi | Market Access | 2 | 38.8 | 0 |
| 100002268 | TACROLIMUS 5 MG CP BLISTER(100002268) | increase | 8.4 | decrease | no change | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Pharma Network SpA | Pharma Network SpA | 2 | -14.0 | 0 |
| 100002314 | SALBUTAMOL 5MG/ML SOL.NEBU FRA 20ML(100002314) | increase | 8.7 | increase | decrease | ETHON PHARMACEUTICALS SPA. | ETHON PHARMACEUTICALS SPA. | ETHON PHARMACEUTICALS SPA. | ETHON PHARMACEUTICALS SPA. | 1 | 142.4 | -1 |
| 100002341 | LEUPRORELINA 11,25MG POLV P/SUSP INYECT (100002341) | decrease | -1.7 | increase | no change | ABBVIE PRODUCTOS FARMACEUTICOS LIMITADA | ABBVIE PRODUCTOS FARMACEUTICOS LIMITADA | ABBVIE PRODUCTOS FARMACEUTICOS LIMITADA | ABBVIE PRODUCTOS FARMACEUTICOS LIMITADA | 1 | 105.3 | 0 |
| 100002344 | MEDROXIPROGESTERONA 104MG/0,65ML JRP/DIS(100002344) | decrease | -1.7 | decrease | no change | LABORATORIOS WYETH LLC | LABORATORIOS WYETH LLC | PFIZER CHILE S.A. | PFIZER CHILE S.A. | 2 | -95.1 | 0 |
| 100002472 | SOMATROPINA HUM. RECOMB 24-30-36UI x UI 100002472 | increase | 44 | increase | decrease | NOVARTIS CHILE S A | NOVARTIS CHILE S A | PFIZER CHILE S.A. | PFIZER CHILE S.A. | 2 | 546.9 | -1 |
| 100002551 | MORFINA 20 MG/ML SOL ORAL HASTA 60ML XML(100002551) | increase | 8.2 | increase | no change | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. | 2 | 95.9 | 0 |
| 100002567 | VENLAFAXINA 75 MG CM/CM REC/CP LIB PROL (100002567) | decrease | -16.2 | increase | increase | Exeltis SpA | Exeltis SpA | Exeltis SpA | Exeltis SpA | 1 | 69.0 | 5 |
| 100002568 | VENLAFAXINA 150 MG CM REC/CP LIB PROL(100002568) | decrease | -22 | increase | increase | Exeltis SpA | Exeltis SpA | Exeltis SpA | Exeltis SpA | 1 | 152.4 | 2 |
| 100002573 | LEVETIRACETAM 100MG/ML SOL.ORAL 300 ML(100002573) | increase | 42.1 | increase | decrease | Alpha Pharma Chile | Alpha Pharma Chile | Laboratorios Lafi | Market Access | 2 | 134.6 | -3 |
| 100002577 | DIVALPROATO AC.500MG CP/CM REC LIB PROL.(100002577) | increase | 39.9 | increase | no change | Abbott Laboratories de Chile Ltda. | Abbott Laboratories de Chile Ltda. - LABORATORIOS RECALCINE S.A | LABORATORIOS RECALCINE S.A | Abbott Laboratories de Chile Ltda. | Abbott Laboratories de Chile Ltda. - Recben | Recben Xenerics Farmaceutica | 3 | 20.9 | 0 |
| 100002634 | ALCOHOL GEL 70° FRA 300 A 500 ML X ML(100002634) | increase | 30.6 | increase | no change | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | 1 | 5215.5 | 0 |
| 100002901 | AMLODIPINO 10 MG CM/CM REC. (100002901) | increase | 25.3 | increase | no change | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA - Pharma Network SpA | Pharma Network SpA | 3 | 94.6 | 0 |
| 100002921 | PARACETAMOL 10 MG/ML SOL.INY FAM/BOL 100002921 | decrease | -47.6 | increase | increase | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | Fresenius Kabi Chile Ltda. | Fresenius Kabi Chile Ltda. | 2 | 435.2 | 2 |
| 100003205 | CILOSTAZOL 100 MG CM (100003205) | decrease | -7.7 | increase | decrease | GALENICUM CHILE | GALENICUM CHILE | GALENICUM CHILE | GALENICUM CHILE | 1 | 133.9 | -2 |
| 100003207 | TRIMEBUTINA 200 MG CM/CM REC/CP 100003207 | decrease | -2.4 | increase | no change | Laboratorio Pasteur SA | Laboratorio Pasteur SA | Laboratorio Pasteur SA | Laboratorio Pasteur SA | 1 | 4.3 | 0 |
| 100003214 | TOPIRAMATO 100 MG CM REC.(100003214) | decrease | -25.7 | increase | increase | WINPHARM SPA | WINPHARM | Tecnofarma S.A. | Tecnofarma S.A. | 2 | 148.6 | 2 |
| 100003217 | MONTELUKAST 5 MG CM MASTIC(100003217) | decrease | -38.1 | increase | decrease | Alpha Pharma Chile | Alpha Pharma Chile | Seven Pharma Chile | Seven Pharma Chile | 2 | 133.4 | -2 |
| 100003221 | LEVOCETIRIZINA 5 MG CM REC/CM BUCODISP (100003221) | decrease | -25.4 | increase | increase | PHARMATRADE S.A | 966706406 | Seven Pharma Chile | Seven Pharma Chile | 2 | 359.1 | 1 |
| 100003230 | DONEPEZILO 10 MG CM REC/CM DISPERSABLE (100003230) | decrease | -62.6 | increase | decrease | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | Alpha Pharma Chile | Alpha Pharma Chile | 2 | 218.5 | -3 |
| 100003231 | MIRTAZAPINA 30 MG CM REC(100003231) | increase | 3.4 | increase | increase | LABORATORIOS RECALCINE S.A | LABORATORIOS RECALCINE S.A | Recben | Recben Xenerics Farmaceutica | 2 | 57.1 | 1 |
| 100003239 | AMLODIPINO 5 MG CM/CM REC.(100003239) | decrease | -21.4 | increase | increase | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables - Alpha Pharma Chile | Alpha Pharma Chile | 2 | 177.0 | 1 |
| 100003250 | DESLORATA 2,5MG/5ML JBE/SOL FRA100-120ML (100003250) | increase | 24.9 | increase | decrease | PHARMATRADE S.A | 966706406 | Laboratorios Lafi | Market Access - LABORATORIO CHILE S.A. | LABORATORIO CHILE S.A. | 3 | 51.5 | -1 |
| 100003251 | MONTELUKAST 4 MG GRANULADO ORAL SOBRE (100003251) | decrease | -42 | increase | increase | PHARMATRADE S.A | 966706406 | LABORATORIOS SANFER DE CHILE S.A. | LABORATORIOS SANFER DE CHILE S.A. | 2 | 128.1 | 1 |
| 100003255 | METFORMINA 500 MG CM RECUBIERTO(100003255) | increase | 111.9 | increase | decrease | Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos | MEDIPHARM S.A. | MEDIPHARM S.A. | 2 | 100.5 | -2 |
| 100003257 | ROSUVASTATINA 10 MG CM REC. BLISTER (100003257) | decrease | -14.7 | increase | decrease | Alpha Pharma Chile | Alpha Pharma Chile | NOVARTIS CHILE S A | NOVARTIS CHILE S A - Alpha Pharma Chile | Alpha Pharma Chile | 2 | 124.0 | -1 |
| 100003265 | BISOPROLOL 1,25 MG CM REC.(100003265) | decrease | -26 | increase | increase | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos - Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos | 2 | 122.7 | 2 |
| 100003414 | ELTROMBOPAG 25MG CM REC 100003414 | decrease | -1.7 | increase | no change | NOVARTIS CHILE S A | NOVARTIS CHILE S A | NOVARTIS CHILE S A | NOVARTIS CHILE S A | 1 | 1863.0 | 0 |
| 100003415 | LATANOP/TIMOLOL 50MCG/5MG/ML FRA2,5 A5ML 100003415 | decrease | -33.2 | increase | increase | Edison Alejandro | Edison Alejandro | Edison Alejandro | Edison Alejandro | 1 | 165.1 | 1 |
| 100003428 | BORTEZOMIB 3,5 MG POLVO LIOF. FAM 100003428 | decrease | -78.9 | increase | decrease | LKM Chile SpA | LKM Chile | NOVARTIS CHILE S A | NOVARTIS CHILE S A - Recben | Recben Xenerics Farmaceutica | 3 | 679.7 | -1 |
| 100003434 | ATORVASTATINA 80MG CM REC(100003434) | decrease | -31.7 | increase | no change | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | LABORATORIO CHILE S.A. | LABORATORIO CHILE S.A. | 2 | 72.1 | 0 |
| 100003443 | SEVELAMER 800 MG CM REC.(100003443) | decrease | -17.6 | increase | increase | SANOFI AVENTIS | SANOFI AVENTIS | PHARMA INVESTI DE CHILE S.A. | PHARMA INVESTI DE CHILE S A | 2 | 71.4 | 1 |
| 100003446 | EVEROLIMUS 10 MG CM(100003446) | decrease | -27.5 | increase | no change | WINPHARM SPA | WINPHARM - WINPHARM SPA | WINPHARM | SYNTHON CHILE LTDA | SYNTHON CHILE LTDA. | 2 | 300.0 | 0 |
| 100003449 | BRIMONIDINA 0,2% SOL OFTALMICA FRA 5 ML(100003449) | decrease | -9.3 | increase | decrease | NOVOFARMA SERVICE S A | NOVOFARMA-SOPHIA | Laboratorios SMB Farma S.A. | Laboratorios SMB Farma S.A. | 2 | 57.1 | -2 |
| 100003462 | TOLTERODINA 2 MG CM O CM REC(100003462) | decrease | -9.3 | increase | decrease | INVERSIONES PHARMAVISAN S.A | INVERSIONES PHARMAVISAN S.A. | Alpha Pharma Chile | Alpha Pharma Chile | 2 | 32.6 | -1 |
| 100003464 | METFORMINA 1000 MG CM REC](100003464) | increase | 13.6 | increase | decrease | PHARMATRADE S.A | 966706406 | SOCOFAR S A | Socofar Division Munnich | 2 | 177.8 | -1 |
| 100003475 | AMANTADINA 100 MG CP/CM(100003475) | decrease | -4.6 | increase | no change | Instituto Sanitas S.A. | Instituto Sanitas S.A. | Instituto Sanitas S.A. | Instituto Sanitas S.A. | 1 | 404.2 | 0 |
| 100003741 | ESTRADIOL 0,5MG GELTRANSDER FRA/SCH X DO 100003741 | increase | 64.8 | decrease | no change | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. | 2 | -99.4 | 0 |
| 100003742 | PROGESTERONA MICRONIZADA 200 MG CP(100003742) | increase | 8.3 | increase | increase | BPH S.A | BPH S.A | LABORATORIOS RECALCINE S.A | LABORATORIOS RECALCINE S.A | 2 | 93.9 | 2 |
| 100003753 | FINGOLIMOD 0,5 MG CP (100003753) | decrease | -79.1 | increase | increase | Alpha Pharma Chile | Alpha Pharma Chile | Ascend Laboratories SpA | Ascend Laboratories SpA | 2 | 116.1 | 5 |
| 100003840 | OLANZAPINA 5 MG CM/CM REC(100003840) | decrease | -19.6 | increase | increase | GALENICUM CHILE | GALENICUM CHILE | Instituto Sanitas S.A. | Instituto Sanitas S.A. | 2 | 216.5 | 2 |
| 100003853 | ISOTRETINOINA 10 MG CP(100003853) | decrease | -36 | increase | increase | PHARMATRADE S.A | 966706406 | Deutsche Pharma S.A. | Deutsche Pharma - PHARMA INVESTI DE CHILE S.A. | PHARMA INVESTI DE CHILE S A | 3 | 304.8 | 2 |
| 100003873 | METFORMINA 1000MG CM/CM REC LIB. PROLONG(100003873) | decrease | -31.7 | increase | increase | OPKO CHILE S.A. | OPKO CHILE S.A. | Laboratorio Pasteur SA | Laboratorio Pasteur SA | 2 | 318.6 | 1 |
| 100003883 | TACROLIMUS 3 MG CP LIB. PROLONG. BLISTER(100003883) | increase | 33 | decrease | decrease | Gador Limitada | GADOR LIMITADA | LABORATORIO CHILE S.A. | LABORATORIO CHILE S.A. | 2 | -66.7 | -2 |
| 100003895 | MUPIROCINA 2% UNG. DERMICO TUBO/POMO(100003895) | decrease | -48.2 | increase | decrease | SOCOFAR S A | Socofar Division Munnich | Laboratorios Lafi | Market Access | 2 | 282.2 | -1 |
| 100003899 | AMFOTERICINA B LIPOSOMAL 50 MG FAM (100003899) | increase | 8.7 | increase | decrease | Gador Limitada | GADOR LIMITADA | Gador Limitada | GADOR LIMITADA | 1 | 25.7 | -2 |
| 100003900 | DUTASTER/TAMSULOS 0,5/0,4 MG CP LIB SOST(100003900) | decrease | -11 | increase | decrease | OPKO CHILE S.A. | OPKO CHILE S.A. | Etex Farmaceútica Limitada | Etex Farmaceútica Limitada - GLAXOSMITHKLINE CHILE FARMACEUTICA LIMITADA | GLAXOSMITHKLINE CHILE FARMACEUTICA LIMITADA | 3 | 104.3 | -1 |
| 100003901 | TRAVOPROST 0,004% SOL.OFT FRA 2,5 ML (100003901) | decrease | -43.7 | increase | no change | NOVARTIS CHILE S A | NOVARTIS CHILE S A | NOVARTIS CHILE S A | NOVARTIS CHILE S A | 1 | 130.1 | 0 |
| 100003903 | PAZOPANIB 400 MG CM REC (100003903) | decrease | -7.4 | increase | no change | Tecnofarma S.A. | Tecnofarma S.A. | Tecnofarma S.A. | Tecnofarma S.A. | 1 | 15.4 | 0 |
| 100003904 | SUGAMMADEX 200 MG/ 2ML SOL.INYECT FAM 100003904 | increase | 1.6 | increase | no change | MERCK SHARP & DOHME (I. A.) LLC Agencia en Chile | MERCK SHARP & DOHME (I. A.) LLC Agencia en Chile | MERCK SHARP & DOHME (I. A.) LLC Agencia en Chile | MERCK SHARP & DOHME (I. A.) LLC Agencia en Chile | 1 | 499.2 | 0 |
| 100003907 | AZACITIDINA 100MG POLV/LIOF SUSP/INY FAM(100003907) | decrease | -21.5 | increase | increase | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | 1 | 10.1 | 1 |
| 100003910 | METOTREXATO 20 MG SOL. INYECT. JRP(100003910) | decrease | -22.1 | increase | no change | LABORATORIO KAMPAR | LABORATORIO KAMPAR | Recben | Recben Xenerics Farmaceutica | 2 | 98.3 | 0 |
| 100003923 | GLUCOSAMIN/CONDROITIN 1500/1200 MG SOBR (100003923) | increase | 23.6 | increase | no change | Tecnofarma S.A. | Tecnofarma S.A. | Tecnofarma S.A. | Tecnofarma S.A. | 1 | 55.2 | 0 |
| 100003926 | DORZOLAMIDA 2% SOL. OFTALMICA FRA 5 ML(100003926) | decrease | -9.8 | increase | decrease | Ascend Laboratories SpA | Ascend Laboratories SpA | Pharma Network SpA | Pharma Network SpA | 2 | 40.7 | -1 |
| 100003930 | EZETIMIBE/ SIMVASTATINA 10/20MG CM(100003930) | decrease | -0.8 | increase | decrease | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | Pharma Network SpA | Pharma Network SpA | 2 | 42.5 | -1 |
| 100003942 | LACOSAMIDA 100 MG CM REC 100003942 | decrease | -31.1 | increase | decrease | Alpha Pharma Chile | Alpha Pharma Chile | Alpha Pharma Chile | Alpha Pharma Chile - Seven Pharma Chile | Seven Pharma Chile | 2 | 133.2 | -1 |
| 100003970 | ESOMEPRAZOL 40 MG CM/CP MICR. REC.ENT (100003970) | decrease | -34.1 | increase | decrease | OPKO CHILE S.A. | OPKO CHILE S.A. | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | 2 | 145.4 | -2 |
| 100004005 | DULOXETINA 30 MG CM REC O CP (100004005) | decrease | -6.1 | increase | increase | Ascend Laboratories SpA | Ascend Laboratories SpA | Alpha Pharma Chile | Alpha Pharma Chile | 2 | 80.0 | 1 |
| 100004064 | LANSOPRAZOL 30MG CP C/MICR.C/REC/ENT 100004064 | decrease | -2.6 | increase | no change | OPKO CHILE S.A. | OPKO CHILE S.A. | LABORATORIO CHILE S.A. | LABORATORIO CHILE S.A. | 2 | 78.8 | 0 |
| 100004081 | CLORHEXIDINA 2% JABON LIQ.FRA 50 ML 100004081 | increase | 1.5 | increase | no change | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A - DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | 1 | 551.8 | 0 |
| 100004371 | RIFAXIMINA 200 MG CM REC(100004371) | decrease | -2.5 | increase | no change | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | 1 | 62.7 | 0 |
| 100004480 | TOXINA BOTULIN A DIST/BLEFA/ESPAS X U (100004480) | decrease | -31.1 | decrease | decrease | LABORATORIOS BIOPAS S.A. | LABORATORIOS BIOPAS S.A. | Allergan Laboratorios Ltda. | Allergan Laboratorios Ltda. | 2 | -78.2 | -2 |
| 100004642 | GEFITINIB 250 MG CM REC.100004642 | decrease | -3.5 | increase | no change | LKM Chile SpA | LKM Chile | Alpha Pharma Chile | Alpha Pharma Chile | 2 | 49.6 | 0 |
| 100004647 | ERLOTINIB 150 MG CM REC.(100004647) | increase | 17.1 | increase | decrease | Alpha Pharma Chile | Alpha Pharma Chile | Alpha Pharma Chile | Alpha Pharma Chile | 1 | 57.4 | -1 |
| 100004671 | PLERIXAFOR 20 MG/ML SOL. INY FAM(100004671) | decrease | -14.2 | increase | no change | Alpha Pharma Chile | Alpha Pharma Chile | Gador Limitada | GADOR LIMITADA | 2 | 86.8 | 0 |
| 100004700 | ABIRATERONA 250 MG CM/CM REC(100004700) | decrease | -64.1 | increase | no change | Alpha Pharma Chile | Alpha Pharma Chile | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | 2 | 136.7 | 0 |
| sup_id | sup_name | proportion_After_2020 | proportion_Before_2020 | unique_medicines_After 2020 | unique_medicines_Before 2020 | change_market | change_market_des |
|---|---|---|---|---|---|---|---|
| CL-MP-1004031 | DR REDDY’S LABORATORIES CHILE SpA | DR REDDY’S LABORATORIES CHILE SpA | 0.3 | 0.7 | 3 | 3 | -0.4 | decreased |
| CL-MP-101513 | PHARMATRADE S.A | 966706406 | 5.2 | 0.5 | 12 | 2 | 4.7 | increased |
| CL-MP-1017374 | Pharma Network SpA | Pharma Network SpA | NA | 2.8 | NA | 8 | NA | NA |
| CL-MP-1022843 | COMERCIAL RM SPA | COMERCIAL RM SPA | NA | 0.7 | NA | 1 | NA | NA |
| CL-MP-106395 | LABORATORIO CHILE S.A. | LABORATORIO CHILE S.A. | NA | 2.1 | NA | 5 | NA | NA |
| CL-MP-120433 | DROGUERIA FARMOQUIMICA DEL PACIFICO LTDA | DROGUERIA FARMOQUIMICA DEL PACIFICO LTDA | 0.3 | 0.3 | 1 | 1 | 0.0 | no change |
| CL-MP-134368 | Johnson & Johnson Medical | 2 Janssen-Cilag Chile | 1.2 | 0.6 | 1 | 1 | 0.6 | increased |
| CL-MP-13784 | MERCK SHARP & DOHME (I. A.) LLC Agencia en Chile | MERCK SHARP & DOHME (I. A.) LLC Agencia en Chile | 2.7 | 0.5 | 1 | 1 | 2.2 | increased |
| CL-MP-138364 | LABORATORIO KAMPAR | LABORATORIO KAMPAR | 1.1 | NA | 1 | NA | NA | NA |
| CL-MP-155496 | INTERPHARMA | INTERPHARMA | 0.3 | NA | 1 | NA | NA | NA |
| CL-MP-19419 | Etex Farmaceútica Limitada | Etex Farmaceútica Limitada | NA | 1.9 | NA | 1 | NA | NA |
| CL-MP-218556 | GUILLERMO HARDING Y CIA LTDA | Munnich Desechables | 6.6 | 6.0 | 15 | 9 | 0.6 | increased |
| CL-MP-224028 | Merck S.A. Productos Químicos | Merck S.A. Productos Farmacéuticos | 4.6 | 6.3 | 3 | 3 | -1.7 | decreased |
| CL-MP-237561 | OPKO CHILE S.A. | OPKO CHILE S.A. | 14.3 | 0.2 | 7 | 1 | 14.1 | increased |
| CL-MP-23890 | Abbott Laboratories de Chile Ltda. | Abbott Laboratories de Chile Ltda. | 2.8 | 1.1 | 1 | 1 | 1.7 | increased |
| CL-MP-24098 | LABORATORIOS WYETH LLC | LABORATORIOS WYETH LLC | 0.7 | 0.4 | 3 | 1 | 0.3 | increased |
| CL-MP-24150 | Roche Chile Ltda. Roche Pharma | Roche Chile Ltda. Roche Pharma | 3.9 | 8.1 | 1 | 1 | -4.2 | decreased |
| CL-MP-24160 | NOVARTIS CHILE S A | NOVARTIS CHILE S A | 2.6 | 6.4 | 4 | 12 | -3.8 | decreased |
| CL-MP-245247 | Novo Nordisk Farmaceutica Limitada | Novo Nordisk Farmaceutica Limitada | 0.3 | NA | 1 | NA | NA | NA |
| CL-MP-24559 | GLAXOSMITHKLINE CHILE FARMACEUTICA LIMITADA | GLAXOSMITHKLINE CHILE FARMACEUTICA LIMITADA | NA | 1.2 | NA | 1 | NA | NA |
| CL-MP-24656 | BUHOS S.C.I. LTDA. | BUHOS S.C.I. LTDA. | 1.2 | NA | 1 | NA | NA | NA |
| CL-MP-24821 | ALCON LABORATORIOS CHILE LTDA | ALCON LABORATORIOS CHILE LTDA - Alcon Chile Farmacéutico | 0.3 | 0.3 | 1 | 1 | 0.0 | no change |
| CL-MP-24938 | Laboratorio Pasteur SA | Laboratorio Pasteur SA | 0.3 | 1.1 | 1 | 3 | -0.8 | decreased |
| CL-MP-25105 | Laboratorio Biosano S.A. | Laboratorio Biosano S.A. | 1.7 | 2.1 | 4 | 5 | -0.4 | decreased |
| CL-MP-26509 | Instituto Sanitas S.A. | Instituto Sanitas S.A. | 0.4 | 0.2 | 3 | 3 | 0.2 | increased |
| CL-MP-26577 | LABORATORIO SANDERSON S.A. | LABORATORIO SANDERSON S.A. | 4.4 | 3.8 | 8 | 8 | 0.6 | increased |
| CL-MP-26578 | SOCOFAR S A | SOCOFAR S A | 0.0 | NA | 1 | NA | NA | NA |
| CL-MP-26581 | LABORATORIOS RECALCINE S.A | LABORATORIOS RECALCINE S.A | 0.6 | 0.2 | 2 | 1 | 0.4 | increased |
| CL-MP-26827 | PHARMA INVESTI DE CHILE S.A. | PHARMA INVESTI DE CHILE S A | NA | 0.3 | NA | 2 | NA | NA |
| CL-MP-26897 | Chemopharma S.A. | Chemopharma S.A. | 0.1 | 2.3 | 1 | 4 | -2.2 | decreased |
| CL-MP-27496 | LABORATORIOS DENTAID S A | LABORATORIOS DENTAID S A | NA | 0.2 | NA | 1 | NA | NA |
| CL-MP-275627 | ETHON PHARMACEUTICALS SPA. | ETHON PHARMACEUTICALS SPA. | 0.3 | 0.1 | 2 | 2 | 0.2 | increased |
| CL-MP-291355 | Labvitalis | Labvitalis | NA | 0.3 | NA | 1 | NA | NA |
| CL-MP-31762 | REUTTER S.A | REUTTER DIVISION MEDICA | 0.1 | NA | 1 | NA | NA | NA |
| CL-MP-32725 | SANOFI AVENTIS | SANOFI AVENTIS | 0.3 | 0.4 | 1 | 1 | -0.1 | decreased |
| CL-MP-35423 | PFIZER CHILE S.A. | PFIZER CHILE S.A. | NA | 4.3 | NA | 5 | NA | NA |
| CL-MP-43858 | Laboratorios SMB Farma S.A. | Laboratorios SMB Farma S.A. | NA | 0.3 | NA | 1 | NA | NA |
| CL-MP-44164 | BPH S.A | BPH S.A | 4.6 | 2.0 | 13 | 8 | 2.6 | increased |
| CL-MP-44934 | Fresenius Kabi Chile Ltda. | Fresenius Kabi Chile Ltda. | 0.1 | 0.7 | 1 | 2 | -0.6 | decreased |
| CL-MP-46106 | INMED DROGUERIA LTDA. | INMED DROGUERIA LTDA. | NA | 1.0 | NA | 1 | NA | NA |
| CL-MP-46982 | Grunenthal Chilena | Grunenthal Chilena - Casa Matriz | 5.0 | 2.1 | 8 | 2 | 2.9 | increased |
| CL-MP-48755 | B.BRAUN MEDICAL SpA2 | B.BRAUN MEDICAL SpA | 0.1 | NA | 1 | NA | NA | NA |
| CL-MP-505933 | Deutsche Pharma S.A. | Deutsche Pharma | NA | 0.0 | NA | 1 | NA | NA |
| CL-MP-51482 | DIFEM LABORATORIOS S A | DIFEM LABORATORIOS S A | 2.5 | 3.2 | 5 | 5 | -0.7 | decreased |
| CL-MP-51922 | Tecnofarma S.A. | Tecnofarma S.A. | 1.2 | 0.9 | 2 | 3 | 0.3 | increased |
| CL-MP-549508 | INVERSIONES PHARMAVISAN S.A | INVERSIONES PHARMAVISAN S.A. | 0.2 | 0.5 | 1 | 1 | -0.3 | decreased |
| CL-MP-550506 | SOCOFAR S A | Socofar Division Munnich | 0.1 | 0.5 | 1 | 2 | -0.4 | decreased |
| CL-MP-55463 | LABORATORIOS RAFFO S.A | LABORATORIOS RAFFO S.A | NA | 0.1 | NA | 1 | NA | NA |
| CL-MP-55470 | LABORATORIO VALMA S.A | LABORATORIO VALMA S.A | NA | 0.2 | NA | 1 | NA | NA |
| CL-MP-57694 | BAXTER CHILE LTDA. | BAXTER CHILE LTDA. | 1.3 | 0.8 | 2 | 2 | 0.5 | increased |
| CL-MP-577519 | ITF Farma Chile | ITF Labomed Farmaceutica Limitada | 0.1 | 0.5 | 1 | 3 | -0.4 | decreased |
| CL-MP-581799 | Diprovet SPA | Diprovet | 0.4 | NA | 1 | NA | NA | NA |
| CL-MP-586852 | WINPHARM SPA | WINPHARM | 0.9 | 0.9 | 3 | 3 | 0.0 | no change |
| CL-MP-59070 | Allergan Laboratorios Ltda. | Allergan Laboratorios Ltda. | NA | 0.8 | NA | 1 | NA | NA |
| CL-MP-59192 | LABORATORIOS SILESIA S.A. | LABORATORIOS SILESIA S.A. | NA | 8.8 | NA | 7 | NA | NA |
| CL-MP-60314 | MEDIPHARM S.A. | MEDIPHARM S.A. | NA | 0.2 | NA | 2 | NA | NA |
| CL-MP-605031 | Gador Limitada | GADOR LIMITADA | 3.6 | 2.8 | 3 | 2 | 0.8 | increased |
| CL-MP-619868 | PHARMATECH CHILE SOCIEDAD ANÓNIMA | PHARMATECH | 0.1 | 0.2 | 1 | 1 | -0.1 | decreased |
| CL-MP-651991 | HOSPIFARMA CHILE LIMITADA | HOSPIFARMA | NA | 0.9 | NA | 3 | NA | NA |
| CL-MP-65433 | PHARMAMERICA LTDA. | PHARMAMERICA LTDA. | 1.2 | 0.5 | 2 | 2 | 0.7 | increased |
| CL-MP-663522 | IMPROFAR | IMPROFAR | NA | 0.1 | NA | 1 | NA | NA |
| CL-MP-668273 | LABORATORIOS BIOPAS S.A. | LABORATORIOS BIOPAS S.A. | 0.1 | NA | 1 | NA | NA | NA |
| CL-MP-677833 | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | ARAMA NATURAL PRODUCTS DISTRIBUIDORA LIMITADA | 0.5 | 2.7 | 2 | 5 | -2.2 | decreased |
| CL-MP-696458 | LABOFAR | LABOFAR | 1.5 | NA | 1 | NA | NA | NA |
| CL-MP-708746 | ABBVIE PRODUCTOS FARMACEUTICOS LIMITADA | ABBVIE PRODUCTOS FARMACEUTICOS LIMITADA | 0.4 | 0.2 | 1 | 1 | 0.2 | increased |
| CL-MP-745653 | Ascend Laboratories SpA | Ascend Laboratories SpA | 7.6 | 1.4 | 7 | 2 | 6.2 | increased |
| CL-MP-780650 | MEDBIOTEC | MEDBIOTEC | 1.7 | NA | 2 | NA | NA | NA |
| CL-MP-81847 | Recben | Recben Xenerics Farmaceutica | NA | 2.6 | NA | 5 | NA | NA |
| CL-MP-825391 | QUALITEC FARMACÉUTICA LTDA. | Qualytec medicamentos | 2.4 | NA | 3 | NA | NA | NA |
| CL-MP-827528 | GALENICUM CHILE | GALENICUM CHILE | 0.6 | 0.1 | 3 | 1 | 0.5 | increased |
| CL-MP-838624 | SYNTHON CHILE LTDA | SYNTHON CHILE LTDA. | NA | 0.1 | NA | 1 | NA | NA |
| CL-MP-84739 | Libra Chile S.A. | Libra Chile S.A. | NA | 0.2 | NA | 1 | NA | NA |
| CL-MP-854608 | Seven Pharma Chile | Seven Pharma Chile | NA | 2.2 | NA | 8 | NA | NA |
| CL-MP-861113 | ZERICUM | ZERICUM | 0.5 | NA | 1 | NA | NA | NA |
| CL-MP-867677 | LKM Chile SpA | LKM Chile | 0.6 | NA | 2 | NA | NA | NA |
| CL-MP-868446 | Exeltis SpA | Exeltis SpA | 0.8 | 0.4 | 3 | 2 | 0.4 | increased |
| CL-MP-875759 | Alpha Pharma Chile | Alpha Pharma Chile | 3.6 | 1.9 | 11 | 9 | 1.7 | increased |
| CL-MP-878107 | Luxypharm SpA | Luxypharm | 0.3 | 0.8 | 1 | 6 | -0.5 | decreased |
| CL-MP-889054 | NOVOFARMA SERVICE S A | NOVOFARMA-SOPHIA | 0.4 | NA | 1 | NA | NA | NA |
| CL-MP-889782 | Pisa Farmaceutica de Chile SpA | Pisa Farmaceutica de Chile SpA | 0.2 | 0.3 | 1 | 1 | -0.1 | decreased |
| CL-MP-922278 | LABORATORIOS SANFER DE CHILE S.A. | LABORATORIOS SANFER DE CHILE S.A. | NA | 0.1 | NA | 1 | NA | NA |
| CL-MP-933126 | NOVOFARMA SERVICE S A | NOVOFARMA - EXELTIS | NA | 0.2 | NA | 1 | NA | NA |
| CL-MP-937625 | Edison Alejandro | Edison Alejandro | 0.1 | 0.1 | 1 | 2 | 0.0 | no change |
| CL-MP-940558 | FARMA STORAGE | FARMA STORAGE | NA | 0.7 | NA | 4 | NA | NA |
| CL-MP-963670 | Geamed S.A. | Geamed S.A. | 0.3 | NA | 1 | NA | NA | NA |
| CL-MP-987341 | Laboratorios Lafi | Market Access | NA | 2.5 | NA | 7 | NA | NA |
| CL-MP-99621 | Trema | Trema | 0.4 | NA | 1 | NA | NA | NA |
We also estimated fixed effects models to test the effect of quantity, the number of tenderers and the period of the purchase on prices. In this case the model controls for all time-invariant differences between medicines. The model is described in the following equation: \[ log(unitprice_{it}) = \beta_{1}(log(Q_{it})+ \beta_{2}Tenderers_{it} +\delta_{i} +\lambda _{t} + \mu_{it} \]
Where:
\[ i= medicine \; (given\;by \;zgen\; code) \] \[ t= period \; of\;the\;purchase\; of\;medicine\;i\;(Before\;2020\;or\;in\;2020) \]
\[ log(unitprice_{it})= Unit \;price \;of \;a \;medicine \;i \;in \; period \;t (log \;scaled)\] \[log(Q_{it})= Quantity \;of \;a \;medicine \;i \;in \;purchase \;t (log \;scaled)\] \[Tenderers_{it}= Number \;of \;tenderers\;of \;a \;medicine \;i \;in \; purchase \;t \]
\[\delta_{i}= Individual \;characteristics \;of\;each \;medicine(fixed\;effects) \] \[\lambda _{t}= period \; of\;the\;purchase(Before\;2020\;or\;in\;2020) \] \[ \mu_{it} = error term \]
The results of the model (controlling for heteroskedasticity) are shown in the output below.An increase of 1 tenderer reduces price by 5% (at the 10% significance level) on average per medicine, and medicines purchased in 2020 show a reduction of 7% on their price on average, compared to the previous period. The estimate shows that the quantity is not statistically signficant, controlling by individual characteristics of the medicine, the number of tenderers and the period.
## Oneway (individual) effect Within Model
##
## Call:
## plm(formula = log_price ~ log_q + tenderers + y20, data = model,
## model = "within", index = c("zgen", "y20"))
##
## Balanced Panel: n = 168, T = 2, N = 336
##
## Residuals:
## Min. 1st Qu. Median
## -0.70705788796948509933 -0.08101769339409994886 -0.00000000000000011102
## 3rd Qu. Max.
## 0.08101769339410126725 0.70705788796948698671
##
## Coefficients:
## Estimate Std. Error t-value Pr(>|t|)
## log_q -0.046866 0.026144 -1.7926 0.074861 .
## tenderers -0.053598 0.017468 -3.0682 0.002518 **
## y201 -0.073823 0.027655 -2.6695 0.008356 **
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## Total Sum of Squares: 9.7061
## Residual Sum of Squares: 8.1433
## R-Squared: 0.16101
## Adj. R-Squared: -0.7034
## F-statistic: 10.5551 on 3 and 165 DF, p-value: 0.0000021825##
## t test of coefficients:
##
## Estimate Std. Error t value Pr(>|t|)
## log_q -0.046866 0.032944 -1.4226 0.156742
## tenderers -0.053598 0.025685 -2.0867 0.038454 *
## y201 -0.073823 0.027201 -2.7140 0.007353 **
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1