DrugCentral targets are curated from referenced publications and others sources. Mechanism-of-action (MoA) targets are convincingly elucidated and published as such with referenced PubMed IDs. Together with approved indications, interpretable or associated with diseases, these comprise very high confidence disease-to-target associations.
## [1] "Wed Jul 15 14:39:00 2020"## [1] "DrugCentral version: 47 (2020-05-16 16:33:06.285)\n"This SQL joins tables with bioactivities, drug structures, and indications.
| omop_concept | gene | target_name | n_drug |
|---|---|---|---|
| Allergic conjunctivitis | HRH1 | Histamine H1 receptor | 37 |
| Schizophrenia | DRD2 | D(2) dopamine receptor | 36 |
| Allergic rhinitis | HRH1 | Histamine H1 receptor | 35 |
| Atopic dermatitis | NR3C1 | Glucocorticoid receptor | 33 |
| Contact dermatitis | NR3C1 | Glucocorticoid receptor | 32 |
| Eruption of skin | NR3C1 | Glucocorticoid receptor | 29 |
| Discoid lupus erythematosus | NR3C1 | Glucocorticoid receptor | 27 |
| Lichen simplex chronicus | NR3C1 | Glucocorticoid receptor | 27 |
| Plaque psoriasis | NR3C1 | Glucocorticoid receptor | 27 |
| Granuloma annulare | NR3C1 | Glucocorticoid receptor | 26 |
| Primary cutaneous T-cell lymphoma | NR3C1 | Glucocorticoid receptor | 26 |
| Pruritus ani | NR3C1 | Glucocorticoid receptor | 26 |
| Scalp psoriasis | NR3C1 | Glucocorticoid receptor | 26 |
| Seborrheic dermatitis | NR3C1 | Glucocorticoid receptor | 26 |
| Infection of skin AND/OR subcutaneous tissue | dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA | Bacterial penicillin-binding protein | 25 |
| Osteoarthritis | PTGS2 | Prostaglandin G/H synthase 2 | 25 |
| Pruritus of genital organs | NR3C1 | Glucocorticoid receptor | 25 |
| Nasal discharge | HRH1 | Histamine H1 receptor | 24 |
| Urticaria | HRH1 | Histamine H1 receptor | 24 |
| Vasomotor rhinitis | HRH1 | Histamine H1 receptor | 24 |
| Seasonal allergic rhinitis | HRH1 | Histamine H1 receptor | 23 |
| Haemophilus influenzae pneumonia | dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA | Bacterial penicillin-binding protein | 22 |
| Rheumatoid arthritis | PTGS2 | Prostaglandin G/H synthase 2 | 22 |
| Streptococcus pyogenes infection | dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA | Bacterial penicillin-binding protein | 22 |
| Allergic rhinitis | NR3C1 | Glucocorticoid receptor | 21 |
| gene | target_name | n_drug |
|---|---|---|
| NR3C1 | Glucocorticoid receptor | 1384 |
| dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA | Bacterial penicillin-binding protein | 1002 |
| gyrA | DNA gyrase subunit A | 420 |
| mrcA | Penicillin-binding protein 1A | 333 |
| mrcB | Penicillin-binding protein 1B | 333 |
| HRH1 | Histamine H1 receptor | 333 |
| ftsI | Peptidoglycan synthase FtsI | 285 |
| gyrA|gyrB | DNA gyrase | 277 |
| parC | DNA topoisomerase 4 subunit A | 197 |
| PTGS2 | Prostaglandin G/H synthase 2 | 173 |
| parC|parE | Topoisomerase IV | 158 |
| DRD2 | D(2) dopamine receptor | 158 |
| ADRB2 | Beta-2 adrenergic receptor | 158 |
| mrdA | Penicillin-binding protein 2 | 157 |
| OPRM1 | Mu-type opioid receptor | 132 |
| PTGS1 | Prostaglandin G/H synthase 1 | 122 |
| SCN5A | Sodium channel protein type 5 subunit alpha | 119 |
| GABRA1|GABRB2|GABRG2 | GABA-A receptor alpha-1/beta-2/gamma-2 | 101 |
| SCN4A | Sodium channel protein type 4 subunit alpha | 97 |
| parC|parE | DNA topoisomerase 4 | 94 |
| ADRB1 | Beta-1 adrenergic receptor | 94 |
| HTR2A | 5-hydroxytryptamine receptor 2A | 93 |
| ERG11 | Lanosterol 14-alpha demethylase | 91 |
| ADRA1A | Alpha-1A adrenergic receptor | 90 |
| CHRM3 | Muscarinic acetylcholine receptor M3 | 90 |