Mòduls significatius
Es selecciones els mòduls correlacionats amb la variable motherGen de manera significativa
| mòdul | correlació | longitud |
|---|---|---|
| black.txt | -0.329 | 303 |
| red.txt | -0.521 | 499 |
| yellow.txt | -0.958 | 4275 |
Separació Possitius i negatius
Es separen els mòduls en correlacionats de manera postiv ai negativa
Negatius
Es selecciona un cutof per al p valor de . El p valor està ajustat per fdr
KEGG
Dotplot
Visualitza la puntuació de l’enrequiment amb el p-valor i el reconte de gens
Xarxa de gens
Xarxa conectant els gens entre diferents procesos biologics (GO o KEGG)
| Description | Description_1 | GeneRatio | |
|---|---|---|---|
| 4 | mmu00020 | Citrate cycle (TCA cycle) | 0.0295858 |
| 1 | mmu00500 | Starch and sucrose metabolism | 0.0414201 |
| 2 | mmu04146 | Peroxisome | 0.0473373 |
| 5 | mmu04714 | Thermogenesis | 0.0769231 |
| 3 | mmu05012 | Parkinson disease | 0.0828402 |
| Description | Description_1 | GeneRatio |
|---|---|---|
| R-MMU-71403 | Citric acid cycle (TCA cycle) | 0.0252525 |
| R-MMU-8982491 | Glycogen metabolism | 0.0252525 |
| R-MMU-1428517 | The citric acid (TCA) cycle and respiratory electron transport | 0.0555556 |
Heatmap
Simplifica la xarxa de gens/processos biològics.
## Warning: Removed 37 rows containing missing values (geom_tile).
Mapa de funcions
Mostra les funcions organitzades en una xarxa conectades pels gens comuns,
UpSet Plot
Visualització de la associació entre gens i conjunts de gens i resalta el solapaments que hi ha.
Vias KEGG
Visualització de les vies KEGG resaltant els gens que hi participen
GO
Dotplot
Visualitza la puntuació de l’enrequiment amb el p-valor i el reconte de gens
Xarxa de gens
Xarxa conectant els gens entre diferents procesos biologics (GO o KEGG)
Heatmap
Simplifica la xarxa de gens/processos biològics.
## Warning: Removed 650 rows containing missing values (geom_tile).
Mapa de funcions
Mostra les funcions organitzades en una xarxa conectades pels gens comuns,
UpSet Plot
Visualització de la associació entre gens i conjunts de gens i resalta el solapaments que hi ha.
Molecular function
| Description | Description_1 | |
|---|---|---|
| GO:0001228 | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0001227 | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0004879 | GO:0004879 | nuclear receptor activity |
| GO:0030374 | GO:0030374 | nuclear receptor transcription coactivator activity |
| GO:0008121 | GO:0008121 | ubiquinol-cytochrome-c reductase activity |
| GO:0008391 | GO:0008391 | arachidonic acid monooxygenase activity |
| GO:0008395 | GO:0008395 | steroid hydroxylase activity |
| GO:0016712 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| GO:0016713 | GO:0016713 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
| GO:0016714 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| GO:0016715 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen |
| GO:0003954 | GO:0003954 | NADH dehydrogenase activity |
| GO:0016652 | GO:0016652 | oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor |
| GO:0016655 | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0016668 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| GO:0033764 | GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0004457 | GO:0004457 | lactate dehydrogenase activity |
| GO:0016616 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016620 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| GO:0016623 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor |
| GO:0016624 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| Description | Description_1 | |
|---|---|---|
| GO:0035642 | GO:0035642 | histone methyltransferase activity (H3-R17 specific) |
| GO:0044020 | GO:0044020 | histone methyltransferase activity (H4-R3 specific) |
| GO:0070611 | GO:0070611 | histone methyltransferase activity (H3-R2 specific) |
| GO:0070612 | GO:0070612 | histone methyltransferase activity (H2A-R3 specific) |
| GO:0042800 | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| GO:0046974 | GO:0046974 | histone methyltransferase activity (H3-K9 specific) |
| GO:0046976 | GO:0046976 | histone methyltransferase activity (H3-K27 specific) |
| GO:0004402 | GO:0004402 | histone acetyltransferase activity |
| GO:0106078 | GO:0106078 | histone succinyltransferase activity |
| GO:0005025 | GO:0005025 | transforming growth factor beta receptor activity, type I |
| GO:0016361 | GO:0016361 | activin receptor activity, type I |
| GO:0004705 | GO:0004705 | JUN kinase activity |
| GO:0005004 | GO:0005004 | GPI-linked ephrin receptor activity |
| GO:0005005 | GO:0005005 | transmembrane-ephrin receptor activity |
| GO:0008310 | GO:0008310 | single-stranded DNA 3’-5’ exodeoxyribonuclease activity |
| GO:0008311 | GO:0008311 | double-stranded DNA 3’-5’ exodeoxyribonuclease activity |
| GO:0004535 | GO:0004535 | poly(A)-specific ribonuclease activity |
| GO:0048101 | GO:0048101 | calcium- and calmodulin-regulated 3’,5’-cyclic-GMP phosphodiesterase activity |
| GO:0033192 | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| GO:0052629 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity |
| Description | Description_1 | |
|---|---|---|
| GO:0035642 | GO:0035642 | histone methyltransferase activity (H3-R17 specific) |
| GO:0044020 | GO:0044020 | histone methyltransferase activity (H4-R3 specific) |
| GO:0070611 | GO:0070611 | histone methyltransferase activity (H3-R2 specific) |
| GO:0070612 | GO:0070612 | histone methyltransferase activity (H2A-R3 specific) |
| GO:0042800 | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| GO:0046974 | GO:0046974 | histone methyltransferase activity (H3-K9 specific) |
| GO:0046976 | GO:0046976 | histone methyltransferase activity (H3-K27 specific) |
| GO:0004402 | GO:0004402 | histone acetyltransferase activity |
| GO:0106078 | GO:0106078 | histone succinyltransferase activity |
| GO:0005025 | GO:0005025 | transforming growth factor beta receptor activity, type I |
| GO:0016361 | GO:0016361 | activin receptor activity, type I |
| GO:0004705 | GO:0004705 | JUN kinase activity |
| GO:0005004 | GO:0005004 | GPI-linked ephrin receptor activity |
| GO:0005005 | GO:0005005 | transmembrane-ephrin receptor activity |
| GO:0008310 | GO:0008310 | single-stranded DNA 3’-5’ exodeoxyribonuclease activity |
| GO:0008311 | GO:0008311 | double-stranded DNA 3’-5’ exodeoxyribonuclease activity |
| GO:0004535 | GO:0004535 | poly(A)-specific ribonuclease activity |
| GO:0048101 | GO:0048101 | calcium- and calmodulin-regulated 3’,5’-cyclic-GMP phosphodiesterase activity |
| GO:0033192 | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| GO:0052629 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity |
| Description | Description_1 | |
|---|---|---|
| GO:0005391 | GO:0005391 | sodium:potassium-exchanging ATPase activity |
| GO:0046961 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism |
| GO:0008553 | GO:0008553 | proton-exporting ATPase activity, phosphorylative mechanism |
Biological proces
| Term_1 | name |
|---|---|
| proteolysis | GO:0006508 |
| ubiquitin-dependent protein catabolic process | GO:0006511 |
| protein metabolic process | GO:0019538 |
| modification-dependent protein catabolic process | GO:0019941 |
| regulation of proteolysis | GO:0030162 |
| regulation of cellular catabolic process | GO:0031329 |
| regulation of protein ubiquitination | GO:0031396 |
| regulation of cellular protein metabolic process | GO:0032268 |
| regulation of protein catabolic process | GO:0042176 |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | GO:0042787 |
| modification-dependent macromolecule catabolic process | GO:0043632 |
| cellular protein catabolic process | GO:0044257 |
| cellular macromolecule catabolic process | GO:0044265 |
| regulation of protein metabolic process | GO:0051246 |
| proteolysis involved in cellular protein catabolic process | GO:0051603 |
| regulation of proteolysis involved in cellular protein catabolic process | GO:1903050 |
| regulation of cellular protein catabolic process | GO:1903362 |
| regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | GO:2000058 |
| Description | Description_1 | |
|---|---|---|
| GO:0007281 | GO:0007281 | germ cell development |
| GO:0007292 | GO:0007292 | female gamete generation |
| GO:0008354 | GO:0008354 | germ cell migration |
| GO:0036093 | GO:0036093 | germ cell proliferation |
| GO:0048232 | GO:0048232 | male gamete generation |
| GO:0007617 | GO:0007617 | mating behavior |
| GO:0007620 | GO:0007620 | copulation |
| GO:0007338 | GO:0007338 | single fertilization |
| GO:0060467 | GO:0060467 | negative regulation of fertilization |
| GO:0080154 | GO:0080154 | regulation of fertilization |
| GO:1905516 | GO:1905516 | positive regulation of fertilization |
| GO:0001555 | GO:0001555 | oocyte growth |
| GO:0001556 | GO:0001556 | oocyte maturation |
| GO:0001675 | GO:0001675 | acrosome assembly |
| GO:0001892 | GO:0001892 | embryonic placenta development |
| GO:0001893 | GO:0001893 | maternal placenta development |
| GO:0007530 | GO:0007530 | sex determination |
| GO:0007548 | GO:0007548 | sex differentiation |
| GO:0009994 | GO:0009994 | oocyte differentiation |
| GO:0033327 | GO:0033327 | Leydig cell differentiation |
| Description | Description_1 | |
|---|---|---|
| GO:1900193 | GO:1900193 | regulation of oocyte maturation |
| GO:1900194 | GO:1900194 | negative regulation of oocyte maturation |
| GO:1903537 | GO:1903537 | meiotic cell cycle process involved in oocyte maturation |
| GO:0060282 | GO:0060282 | positive regulation of oocyte development |
| GO:0060283 | GO:0060283 | negative regulation of oocyte development |
| GO:1903538 | GO:1903538 | regulation of meiotic cell cycle process involved in oocyte maturation |
| GO:1904145 | GO:1904145 | negative regulation of meiotic cell cycle process involved in oocyte maturation |
| GO:0060474 | GO:0060474 | positive regulation of flagellated sperm motility involved in capacitation |
| GO:0060009 | GO:0060009 | Sertoli cell development |
| GO:0042701 | GO:0042701 | progesterone secretion |
| GO:2000870 | GO:2000870 | regulation of progesterone secretion |
| GO:0097368 | GO:0097368 | establishment of Sertoli cell barrier |
| GO:0060670 | GO:0060670 | branching involved in labyrinthine layer morphogenesis |
| GO:0060710 | GO:0060710 | chorio-allantoic fusion |
| GO:0060685 | GO:0060685 | regulation of prostatic bud formation |
| GO:0060686 | GO:0060686 | negative regulation of prostatic bud formation |
| GO:0048133 | GO:0048133 | male germ-line stem cell asymmetric division |
| GO:0048599 | GO:0048599 | oocyte development |
| GO:0060281 | GO:0060281 | regulation of oocyte development |
| GO:1905880 | GO:1905880 | negative regulation of oogenesis |
| Description | Description_1 | |
|---|---|---|
| GO:0072362 | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter |
| GO:0072363 | GO:0072363 | regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter |
| GO:0045820 | GO:0045820 | negative regulation of glycolytic process |
| GO:0045821 | GO:0045821 | positive regulation of glycolytic process |
| GO:0072361 | GO:0072361 | regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter |
| GO:0006120 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| GO:0006121 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone |
| GO:0006122 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
| GO:0000395 | GO:0000395 | mRNA 5’-splice site recognition |
| GO:1990441 | GO:1990441 | negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| GO:0000432 | GO:0000432 | positive regulation of transcription from RNA polymerase II promoter by glucose |
| GO:0000435 | GO:0000435 | positive regulation of transcription from RNA polymerase II promoter by galactose |
| GO:0030513 | GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0030514 | GO:0030514 | negative regulation of BMP signaling pathway |
| GO:0010768 | GO:0010768 | negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage |
| GO:0045899 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly |
| GO:0035948 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter |
| GO:0007253 | GO:0007253 | cytoplasmic sequestering of NF-kappaB |
| GO:1901838 | GO:1901838 | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| GO:0007256 | GO:0007256 | activation of JNKK activity |
msigdbr
H: hallmark gene sets
C1: positional gene sets
C2: curated gene sets
C3: motif gene sets
C4: computational gene sets
C5: GO gene sets
C6: oncogenic signatures
C7: immunologic signatures
Categoria H
Categoria C1
Categoria C2
Categoria C3
Categoria C4
Categoria C5
Categoria C6
Categoria C7
WikiPathway
| ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | qvalue | geneID | Count | |
|---|---|---|---|---|---|---|---|---|---|
| WP571 | WP571 | FAS pathway and Stress induction of HSP regulation | 12/516 | 37/4644 | 0.0004225 | 0.0460839 | 0.0441837 | 11857/12371/13163/13368/15507/16476/16906/16907/26398/26419/17164/19645 | 12 |
| WP539 | WP539 | Wnt Signaling Pathway NetPath | 24/516 | 108/4644 | 0.0005871 | 0.0460839 | 0.0441837 | 26992/12325/12995/13000/13017/26965/208846/13385/13542/14366/14371/56637/15258/16476/16480/26417/26419/93960/18099/12393/56505/58198/17128/76281 | 24 |
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