Mòduls correlacionats significativament

Fenotip MotherGen

IdISBa-Unitat Bioinformàtica

2020-07-02

Mòduls significatius

Es selecciones els mòduls correlacionats amb la variable motherGen de manera significativa

Mòduls significatius MotherGen
mòdul correlació longitud
green.txt 0.539 608
magenta.txt 0.550 203
tan.txt 0.478 65
salmon.txt 0.447 64
darkred.txt 0.441 25
grey60.txt 0.457 50
cyan.txt 0.562 48
brown.txt 0.994 6139
turquoise.txt 0.835 14785
midnightblue.txt 0.348 35
greenyellow.txt 0.344 104

Separació Possitius i negatius

Es separen els mòduls en correlacionats de manera postiv ai negativa

Postius

Es selecciona un cutof per al p valor de 0.05. El p valor està ajustat per fdr

KEGG

Dotplot

Visualitza la puntuació de l’enrequiment amb el p-valor i el reconte de gens

Xarxa de gens

Xarxa conectant els gens entre diferents procesos biologics (GO o KEGG)

Description Description_1
mmu04120 Ubiquitin mediated proteolysis
mmu05012 Parkinson disease
mmu05016 Huntington disease
mmu03040 Spliceosome
mmu03013 RNA transport
mmu05216 Thyroid cancer
mmu04260 Cardiac muscle contraction
mmu05410 Hypertrophic cardiomyopathy (HCM)
mmu05414 Dilated cardiomyopathy (DCM)
mmu04261 Adrenergic signaling in cardiomyocytes
mmu03013 RNA transport
mmu04710 Circadian rhythm
mmu04713 Circadian entrainment
mmu04120 Ubiquitin mediated proteolysis
mmu04141 Protein processing in endoplasmic reticulum
mmu04061 Viral protein interaction with cytokine and cytokine receptor
mmu04064 NF-kappa B signaling pathway
mmu04062 Chemokine signaling pathway
mmu04060 Cytokine-cytokine receptor interaction
mmu04910 Insulin signaling pathway
mmu04080 Neuroactive ligand-receptor interaction
mmu04726 Serotonergic synapse
mmu05033 Nicotine addiction
mmu04971 Gastric acid secretion
mmu04024 cAMP signaling pathway

Description Description_1
R-MMU-196071 Metabolism of steroid hormones
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72649 Translation initiation complex formation
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-MMU-72766 Translation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-8951664 Neddylation
R-MMU-72613 Eukaryotic Translation Initiation
R-MMU-72737 Cap-dependent Translation Initiation
R-MMU-8852135 Protein ubiquitination
R-MMU-983169 Class I MHC mediated antigen processing & presentation
R-MMU-8873719 RAB geranylgeranylation
R-MMU-429947 Deadenylation of mRNA
R-MMU-1169408 ISG15 antiviral mechanism
R-MMU-445355 Smooth Muscle Contraction
R-MMU-1169410 Antiviral mechanism by IFN-stimulated genes
R-MMU-390522 Striated Muscle Contraction
R-MMU-429914 Deadenylation-dependent mRNA decay
R-MMU-72649 Translation initiation complex formation
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-MMU-913531 Interferon Signaling
R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-72613 Eukaryotic Translation Initiation
R-MMU-72737 Cap-dependent Translation Initiation
R-MMU-397014 Muscle contraction
R-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1480926 O2/CO2 exchange in erythrocytes
R-MMU-3299685 Detoxification of Reactive Oxygen Species
R-MMU-2980736 Peptide hormone metabolism
R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-373076 Class A/1 (Rhodopsin-like receptors)
R-MMU-418594 G alpha (i) signalling events
R-MMU-500792 GPCR ligand binding
R-MMU-112316 Neuronal System

Heatmap

Simplifica la xarxa de gens/processos biològics.

## Warning: Removed 1596 rows containing missing values (geom_tile).

Mapa de funcions

Mostra les funcions organitzades en una xarxa conectades pels gens comuns,

UpSet Plot

Visualització de la associació entre gens i conjunts de gens i resalta el solapaments que hi ha.

Vias KEGG

Visualització de les vies KEGG resaltant els gens que hi participen

GO

Dotplot

Visualitza la puntuació de l’enrequiment amb el p-valor i el reconte de gens

Xarxa de gens

Xarxa conectant els gens entre diferents procesos biologics (GO o KEGG)

Heatmap

Simplifica la xarxa de gens/processos biològics.

## Warning: Removed 3842 rows containing missing values (geom_tile).

Mapa de funcions

Mostra les funcions organitzades en una xarxa conectades pels gens comuns,

UpSet Plot

Visualització de la associació entre gens i conjunts de gens i resalta el solapaments que hi ha.

Molecular function

Description Description_1
GO:0001228 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001227 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0004879 GO:0004879 nuclear receptor activity
GO:0030374 GO:0030374 nuclear receptor transcription coactivator activity
GO:0004129 GO:0004129 cytochrome-c oxidase activity
GO:0004174 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity
GO:0008121 GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0045155 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
GO:0008391 GO:0008391 arachidonic acid monooxygenase activity
GO:0008395 GO:0008395 steroid hydroxylase activity
GO:0008401 GO:0008401 retinoic acid 4-hydroxylase activity
GO:0008403 GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity
GO:0016709 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0016713 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
GO:0016714 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0016715 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0016716 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0019135 GO:0019135 deoxyhypusine monooxygenase activity
GO:0071614 GO:0071614 linoleic acid epoxygenase activity
GO:0003954 GO:0003954 NADH dehydrogenase activity

Description Description_1
GO:0044020 GO:0044020 histone methyltransferase activity (H4-R3 specific)
GO:0031151 GO:0031151 histone methyltransferase activity (H3-K79 specific)
GO:0042800 GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0046974 GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0046975 GO:0046975 histone methyltransferase activity (H3-K36 specific)
GO:0046976 GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0004671 GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0030697 GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
GO:0052905 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity
GO:0052909 GO:0052909 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
GO:1990189 GO:1990189 peptide-serine-N-acetyltransferase activity
GO:1990190 GO:1990190 peptide-glutamate-N-acetyltransferase activity
GO:0004402 GO:0004402 histone acetyltransferase activity
GO:0019799 GO:0019799 tubulin N-acetyltransferase activity
GO:0005025 GO:0005025 transforming growth factor beta receptor activity, type I
GO:0070123 GO:0070123 transforming growth factor beta receptor activity, type III
GO:0016361 GO:0016361 activin receptor activity, type I
GO:0004705 GO:0004705 JUN kinase activity
GO:0005004 GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 GO:0005005 transmembrane-ephrin receptor activity

Description Description_1
GO:0044020 GO:0044020 histone methyltransferase activity (H4-R3 specific)
GO:0031151 GO:0031151 histone methyltransferase activity (H3-K79 specific)
GO:0042800 GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0046974 GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0046975 GO:0046975 histone methyltransferase activity (H3-K36 specific)
GO:0046976 GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0004671 GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0030697 GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
GO:0052905 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity
GO:0052909 GO:0052909 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
GO:1990189 GO:1990189 peptide-serine-N-acetyltransferase activity
GO:1990190 GO:1990190 peptide-glutamate-N-acetyltransferase activity
GO:0004402 GO:0004402 histone acetyltransferase activity
GO:0019799 GO:0019799 tubulin N-acetyltransferase activity
GO:0005025 GO:0005025 transforming growth factor beta receptor activity, type I
GO:0070123 GO:0070123 transforming growth factor beta receptor activity, type III
GO:0016361 GO:0016361 activin receptor activity, type I
GO:0004705 GO:0004705 JUN kinase activity
GO:0005004 GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 GO:0005005 transmembrane-ephrin receptor activity

Description Description_1
GO:1905056 GO:1905056 calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1905059 GO:1905059 calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:0005391 GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0008900 GO:0008900 potassium:proton exchanging ATPase activity
GO:0046961 GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0008553 GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism

Biological proces

Term_1 name
reproduction GO:0000003
developmental process involved in reproduction GO:0003006
multicellular organism development GO:0007275
biological_process GO:0008150
metabolic process GO:0008152
reproductive process GO:0022414
multicellular organismal process GO:0032501
developmental process GO:0032502
single-multicellular organism process GO:0044707
single-organism developmental process GO:0044767
reproductive structure development GO:0048608
system development GO:0048731
anatomical structure development GO:0048856
reproductive system development GO:0061458
organic substance metabolic process GO:0071704
organic hydroxy compound metabolic process GO:1901615

Description Description_1
GO:0007281 GO:0007281 germ cell development
GO:0007292 GO:0007292 female gamete generation
GO:0008354 GO:0008354 germ cell migration
GO:0036093 GO:0036093 germ cell proliferation
GO:0043046 GO:0043046 DNA methylation involved in gamete generation
GO:0048232 GO:0048232 male gamete generation
GO:0007617 GO:0007617 mating behavior
GO:0007620 GO:0007620 copulation
GO:0007338 GO:0007338 single fertilization
GO:0060467 GO:0060467 negative regulation of fertilization
GO:0080154 GO:0080154 regulation of fertilization
GO:1905516 GO:1905516 positive regulation of fertilization
GO:0001547 GO:0001547 antral ovarian follicle growth
GO:0001552 GO:0001552 ovarian follicle atresia
GO:0001555 GO:0001555 oocyte growth
GO:0001556 GO:0001556 oocyte maturation
GO:0001675 GO:0001675 acrosome assembly
GO:0001880 GO:0001880 Mullerian duct regression
GO:0001892 GO:0001892 embryonic placenta development
GO:0001893 GO:0001893 maternal placenta development

Description Description_1
GO:1900193 GO:1900193 regulation of oocyte maturation
GO:1900194 GO:1900194 negative regulation of oocyte maturation
GO:1900195 GO:1900195 positive regulation of oocyte maturation
GO:1903537 GO:1903537 meiotic cell cycle process involved in oocyte maturation
GO:0007309 GO:0007309 oocyte axis specification
GO:0060282 GO:0060282 positive regulation of oocyte development
GO:0060283 GO:0060283 negative regulation of oocyte development
GO:1903538 GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation
GO:0007315 GO:0007315 pole plasm assembly
GO:0007290 GO:0007290 spermatid nucleus elongation
GO:0035092 GO:0035092 sperm chromatin condensation
GO:0060474 GO:0060474 positive regulation of flagellated sperm motility involved in capacitation
GO:1902490 GO:1902490 regulation of sperm capacitation
GO:1902491 GO:1902491 negative regulation of sperm capacitation
GO:0060009 GO:0060009 Sertoli cell development
GO:1904444 GO:1904444 regulation of establishment of Sertoli cell barrier
GO:2000019 GO:2000019 negative regulation of male gonad development
GO:2000020 GO:2000020 positive regulation of male gonad development
GO:1904445 GO:1904445 negative regulation of establishment of Sertoli cell barrier
GO:1904446 GO:1904446 positive regulation of establishment of Sertoli cell barrier

Description Description_1
GO:0030719 GO:0030719 P granule organization
GO:0061188 GO:0061188 negative regulation of chromatin silencing at rDNA
GO:0090309 GO:0090309 positive regulation of methylation-dependent chromatin silencing
GO:0090310 GO:0090310 negative regulation of methylation-dependent chromatin silencing
GO:0031940 GO:0031940 positive regulation of chromatin silencing at telomere
GO:0035582 GO:0035582 sequestering of BMP in extracellular matrix
GO:0038098 GO:0038098 sequestering of BMP from receptor via BMP binding
GO:2001165 GO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
GO:1900175 GO:1900175 regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900176 GO:1900176 negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900146 GO:1900146 negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
GO:0072363 GO:0072363 regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0061621 GO:0061621 canonical glycolysis
GO:0061622 GO:0061622 glycolytic process through glucose-1-phosphate
GO:0061623 GO:0061623 glycolytic process from galactose
GO:0093001 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate
GO:1902958 GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:0045820 GO:0045820 negative regulation of glycolytic process
GO:0045821 GO:0045821 positive regulation of glycolytic process
GO:0072361 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter

msigdbr

  • H: hallmark gene sets

  • C1: positional gene sets

  • C2: curated gene sets

  • C3: motif gene sets

  • C4: computational gene sets

  • C5: GO gene sets

  • C6: oncogenic signatures

  • C7: immunologic signatures

Categoria H

Categoria C1

Categoria C2

## 
## 
##                                               ID                                            Description                                   GeneRatio   BgRatio        pvalue    p.adjust      qvalue  geneID                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Count
## --------------------------------------------  --------------------------------------------  --------------------------------------------  ----------  ----------  ---------  ----------  ----------  -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------
## MEISSNER_BRAIN_HCP_WITH_H3K27ME3              MEISSNER_BRAIN_HCP_WITH_H3K27ME3              MEISSNER_BRAIN_HCP_WITH_H3K27ME3              184/9027    268/17218    0.00e+00   0.0001808   0.0001808  11568/56847/216285/11694/93835/75305/11830/53313/14422/54422/104382/12022/140489/12173/12311/80794/109332/12590/12614/12647/110834/12739/224912/13081/13082/320997/13172/13363/107585/13386/140477/74129/50796/242523/70433/13599/17075/13984/69627/107221/14175/14179/14186/64290/14240/17301/15221/110805/30923/14241/116810/14419/14463/14472/14581/14587/14683/14711/14765/170483/14836/14843/234219/15206/15364/15371/15373/21410/15395/15396/15398/15401/15413/15414/15415/15417/109663/15421/15422/15424/15429/15430/15431/15432/15433/16002/140488/75426/22780/16162/23920/54139/16372/50916/333088/69073/16668/16814/16815/329252/16869/16871/16873/16875/17357/215723/27217/17390/17927/217214/230822/18014/11925/21869/18091/12020/18096/18131/18142/109648/78405/94222/246086/21906/18420/18426/18503/100102/18609/11859/18740/18741/18772/66857/213522/18997/232941/230025/383491/107751/19213/217212/19434/76572/56315/228770/99377/224024/20277/20464/20465/20472/20476/214084/20508/230810/67473/20538/66722/50525/20732/57765/277353/58865/210510/21420/332937/21908/27140/380863/66260/21928/81877/22062/63873/22286/12677/269633/22410/22414/22415/22416/22422/20834                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       184
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN   GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN   GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN   209/9027    315/17218    3.00e-07   0.0007109   0.0007109  27403/27406/56215/11603/109674/68423/69596/213498/16800/76813/108888/73242/13498/233871/22385/223770/12323/50817/219158/104445/57912/11444/71722/53609/74157/216846/26895/269061/27373/12388/66515/78309/231871/70248/98193/227525/229541/277854/216877/13401/208266/66811/112403/110147/27979/13854/14050/68952/14087/231863/233902/230903/243867/55935/54601/18550/23879/234366/230101/106039/223752/243547/54645/14885/76478/15161/170787/56233/29816/11991/26386/15983/234836/16068/16201/68510/69707/16529/233877/230674/16549/118445/381022/214669/224640/232798/16886/16897/627607/16995/26396/19094/30957/13728/17192/244049/100019/17261/27008/28010/50932/64658/229524/56717/59310/17925/380969/216860/18038/70930/72181/328250/18515/192285/68479/68961/75454/18693/18720/14208/232807/71474/226169/53761/56361/60507/81000/71810/19387/380711/19647/381626/66932/433809/235315/19899/20166/12399/224902/216161/240667/57743/20359/233904/72895/84505/231769/20389/105835/20401/24055/79566/83704/54338/106947/83797/229512/71997/227644/56632/100689/73218/75956/83701/20869/234373/77053/72195/68188/230676/70439/381085/21423/77832/21678/70381/331401/230917/216157/51789/212999/320938/67976/22030/72026/100683/52588/234875/74569/68736/22185/70450/103149/382038/30941/22321/72322/230119/20286/80902/54201/140482/66056/68992/213753/18139/233905/103836/52915                                                                                                                                                                                                                                                                                                                                                                                             209
## MIKKELSEN_NPC_HCP_WITH_H3K27ME3               MIKKELSEN_NPC_HCP_WITH_H3K27ME3               MIKKELSEN_NPC_HCP_WITH_H3K27ME3               220/9027    342/17218    4.70e-06   0.0072839   0.0072839  11307/107831/11553/224833/11682/216285/11694/383787/192113/11941/227327/14422/14025/140489/12161/12173/23829/226359/67445/94332/12311/72605/228942/12426/12564/12614/12647/64085/83674/21367/12819/140792/12889/240058/242939/224912/72832/12958/57266/13082/216393/13172/70059/140477/50796/226049/76088/269109/13489/114873/13599/66892/13842/14029/109349/219148/69627/237730/54713/107221/14169/14175/14255/14240/15221/30923/15228/14241/116810/110886/14407/271786/14581/14619/14617/14807/14810/14812/108073/14842/14843/15162/15166/230777/94253/15206/15396/15398/15413/15415/15417/209448/15422/15427/15430/15431/170638/99296/15550/15566/16002/75426/22778/22780/243621/16392/57340/16510/16527/16535/16539/243043/16763/16814/213409/16873/16875/83557/16891/79235/238205/227618/27217/380684/18013/11925/21869/18089/18096/101613/18142/18143/18232/246086/21906/18420/18426/18503/18505/18591/18609/18667/327958/18740/216166/72324/18997/232941/269643/70673/18762/50501/246313/19132/19213/19275/19281/217212/75767/268451/58222/380711/74563/52897/72388/104582/65079/94226/99377/399548/20271/20278/170729/380702/24058/20464/20465/20476/78473/207667/140919/20519/22784/69354/229706/13162/104245/241919/226999/30927/66673/78088/20672/20732/20743/56013/20451/20257/29859/20980/57765/21407/21420/226896/21908/27140/270893/231503/72160/21934/22062/22068/22286/270097/22337/22354/114889/240675/22408/22416                                                                                                                                                                                                                                                                                                                                          220
## MIKKELSEN_MCV6_HCP_WITH_H3K27ME3              MIKKELSEN_MCV6_HCP_WITH_H3K27ME3              MIKKELSEN_MCV6_HCP_WITH_H3K27ME3              270/9027    435/17218    2.53e-05   0.0295863   0.0295863  75434/20927/319713/11423/11482/107831/11540/11553/11568/106877/16764/72168/11634/56847/11686/11687/11733/383787/11830/11878/17173/11419/11418/11941/320707/93961/12022/320522/140489/12124/12161/12217/23829/226359/67445/12289/12291/239556/12294/54377/12323/12424/12426/104010/108013/12647/269610/69121/110834/11444/64085/83674/21367/12819/240058/57266/13081/13116/56320/72185/13363/107585/54427/13447/208869/623279/269109/70433/13508/26903/228598/13599/58229/13637/13823/13842/270190/14029/270028/329274/213956/69640/330450/237730/330369/54713/14167/14176/14179/384061/14240/15221/110805/30923/242425/14397/110886/14403/14419/14463/14573/14587/14623/104174/14800/14803/170935/170483/74053/14816/14843/230777/15208/214305/15371/209448/15421/15427/15431/15432/195646/15552/15565/15566/23920/15900/50916/16398/57340/16490/16504/99738/56543/16510/16511/192775/16520/16535/60613/16539/227632/69073/16591/16728/76161/16814/213469/269629/16871/16873/381983/211187/17005/69032/17183/27217/17395/105689/16918/244281/17927/380684/54003/18014/11925/18018/18072/18089/18091/18095/18096/27386/170484/53324/18183/18190/18217/18232/102644/246086/69602/18430/23969/406218/74090/18574/18584/18609/319655/230025/381813/107751/74002/19213/19259/19263/19281/217212/229214/268451/51801/74563/276952/19434/52897/19662/19699/241770/104582/228770/65079/399548/20271/20273/20277/170729/56788/237979/20361/56747/237353/214547/20465/20472/78473/207667/214084/20508/22348/76157/210027/232333/229706/20538/104245/105243/20562/233744/20743/20605/20609/57740/20262/627191/54526/238266/20980/54524/57765/21645/210510/332937/270893/210573/320500/66260/60455/69539/22062/320736/114889/12677/269633/22410/22414/22416/22422/320916/53422/22771      270

Categoria C3

Categoria C4

## 
## 
##              ID           Description   GeneRatio   BgRatio        pvalue    p.adjust      qvalue  geneID                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Count
## -----------  -----------  ------------  ----------  ---------  ----------  ----------  ----------  --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------
## MODULE_215   MODULE_215   MODULE_215    15/5071     15/9546     0.0000750   0.0382453   0.0362276  108043/14395/110886/14399/14400/14401/14402/14403/14406/216643/14654/237213/110304/14658/15561                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              15
## MORF_FOSL1   MORF_FOSL1   MORF_FOSL1    243/5071    389/9546    0.0000912   0.0382453   0.0362276  76967/230757/56325/20927/100705/384806/23793/269959/11516/11549/228061/23802/11810/11830/99371/11941/11945/21871/54670/110616/12023/12043/12125/12154/224630/223770/57261/26363/260299/140904/100503659/12771/12501/12511/12525/226751/12561/12593/26365/13706/382090/60322/270166/53870/12823/12837/269132/382864/12850/56373/208922/242939/12921/13030/69888/13106/64385/277854/234130/13400/56429/13527/230857/13612/111173/13982/14063/14065/14102/14254/14283/320365/72313/14309/14394/14401/14531/14602/14622/100041146/66355/14706/14712/237943/241070/110168/14760/14805/14809/243547/107766/56541/387285/58180/21405/109663/15492/15494/15551/15561/15562/15566/16002/16157/16163/16170/16189/16196/64436/72999/226432/434232/223272/16426/16427/320404/16447/382207/16449/16469/77532/235041/80880/16493/58179/16681/71888/16672/16679/16841/16939/17085/17140/14924/26400/17175/17203/17246/29808/17354/68481/17686/17692/17701/17752/17882/17925/17932/80987/17996/54446/74164/18126/18132/18143/23957/18171/22025/13865/110784/18187/18188/18189/66566/218066/75475/76303/78826/18511/55982/18577/225600/102693/18935/17344/27276/229791/18846/19009/218030/329251/225849/19076/18750/228769/19211/19263/52118/12421/19656/51902/225998/68750/20199/107767/244891/20272/56747/20379/24052/20465/20476/56643/217316/105355/18399/22784/20536/20538/233789/56504/170460/54200/29859/109115/20975/57752/77097/83993/21812/21846/216821/327766/665113/83813/21848/223435/22115/75425/63958/29869/109637/74270/22288/22380/22414/22666/81630/80902/233410/209225/22787/432731      243
## MORF_IFNA1   MORF_IFNA1   MORF_IFNA1    126/5071    191/9546    0.0001886   0.0418842   0.0396745  384806/23793/269959/99633/11810/12915/11941/11945/54670/110616/12154/57261/12293/260299/140904/100072/12771/12564/382253/26365/382090/12727/12823/12837/269132/12850/56373/12921/13030/13106/13164/13171/13400/76829/13612/14048/14063/269514/14161/14173/399558/14283/14309/14401/14531/14622/110304/100041146/14706/241070/110168/14760/14805/14917/245650/14934/387285/15203/21405/15492/15494/16189/16196/226432/16392/223272/16426/382207/77532/16493/58179/16681/16672/16841/15450/17140/26400/26401/17203/17246/17354/17882/17996/319211/18143/18171/110784/218066/18416/78826/225600/102693/18935/229791/218030/18750/19263/19279/52118/52013/12421/245688/26564/225998/68750/20190/20199/24052/20465/20476/56643/20504/23985/20538/69726/29859/109115/83993/21892/327766/83813/21848/22115/22666/80902/432731                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     126
## MORF_DDX11   MORF_DDX11   MORF_DDX11    102/5071    151/9546    0.0001997   0.0418842   0.0396745  11490/77794/55979/23802/106585/11830/57370/228536/12043/26363/67488/12323/12366/69562/12569/68379/270166/12799/21367/54188/12909/12922/56429/225898/14068/381217/68521/60534/14149/338355/108148/64095/14809/14772/209357/15353/106894/15388/26386/15562/15566/106633/20589/235086/16363/272359/16582/67207/17005/51812/17701/17752/17827/17906/17925/80987/15531/58202/235134/18045/56409/69837/67199/55981/18739/268930/66905/67037/66053/19089/19132/54373/56294/56187/19386/225182/19891/58988/208043/231769/70661/20498/67863/22784/246787/14664/20741/20609/108903/21414/385380/70549/75604/71947/21958/70026/75425/71472/22410/80707/233410/72739                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   102

Categoria C5

Categoria C6

## 
## 
##                ID             Description    GeneRatio   BgRatio         pvalue    p.adjust      qvalue  geneID                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Count
## -------------  -------------  -------------  ----------  ----------  ----------  ----------  ----------  ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------
## ALK_DN.V1_UP   ALK_DN.V1_UP   ALK_DN.V1_UP   91/5492     130/10150    0.0001426   0.0269592   0.0269592  83766/11489/11704/11601/57875/64008/27053/54218/12167/12182/12349/12350/332579/76718/12411/24047/20297/12454/12611/12638/12642/68947/269582/12964/209294/26378/13406/18606/215446/13819/13874/14009/14079/50788/56636/14221/14261/14635/23886/14563/14816/14829/72690/16136/16178/16193/70789/83557/17001/170790/17523/17532/17768/18038/18111/257632/18211/100503041/18155/12142/107272/76938/67747/20130/20208/20209/20265/20274/75345/171286/20512/20514/14664/26570/67652/20750/20257/21372/21385/56720/21426/69876/58217/228775/244178/382018/22339/320736/22433/67778/20834       91

Categoria C7

WikiPathway

ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
WP79 WP79 Tryptophan metabolism 34/2378 44/4644 0.0003288 0.0542495 0.0522595 23923/71562/11668/11671/56752/11761/107626/12359/13075/13076/13077/72082/13106/64385/13123/13195/74754/93747/270076/107766/15107/15108/15930/21743/70789/109731/17246/15469/57751/56720/21990/22215/70790/22375 34
WP2074 WP2074 Neural Crest Differentiation 68/2378 101/4644 0.0006694 0.0552288 0.0532029 17172/12005/12162/12563/241201/13190/13388/54485/13395/140477/13544/23871/14170/14173/14179/14182/15221/14365/14472/14580/14618/433759/170787/15183/208727/15185/56233/70315/79221/15208/15214/15394/15901/16392/16869/16870/16873/17196/12587/17342/17702/17703/17863/18014/18033/18128/18129/18131/18132/50914/94222/18505/18935/18858/235472/19664/11852/20613/20665/20678/20682/21389/21413/21418/22160/22408/22416/22771 68
## wrong orderBy parameter; set to default `orderBy = "x"`