Abs

.

1 Partea generală

2 Partea specială

2.1 Introducere

2.1.1 Obiective

2.2 Material și metode

2.3 Rezultate

Table 1: .

Variable	Details	yes	no	Total	Statistics
TIPS		104 (18.7%)	452 (81.3%)	556
Column1	M (min:max)
	μ ±SD
Obs		4 (3.8%)	7 (1.5%)	11 (2.0%)	OR=2.54 [0.73, 8.85] (p=0.132)
months till dg	M (min:max)	19 (14:25)	7 (2:37)	13.5 (2:37)	T-test: p=0.666
	μ ±SD	19.33 ±5.51	15.14 ±15.3	16.40 ±13.0
HCC 1 an		0	4 (0.9%)	4 (0.7%)	OR=0.48 [0.03, 8.93] (p>0.999)
HCC 2 ani		2 (1.9%)	5 (1.1%)	7 (1.3%)	OR=1.75 [0.34, 9.16] (p=0.620)
HCC 3 ani		3 (2.9%)	6 (1.3%)	9 (1.6%)	OR=2.21 [0.54, 8.98] (p=0.380)
Sex	F	33 (31.7%)	205 (45.4%)	238 (42.8%)	OR=0.56 [0.36, 0.88] (p=0.012)
	M	71 (68.3%)	247 (54.6%)	318 (57.2%)
Age (years)	M (min:max)	55 (25:73)	58 (23:87)	57 (23:87)	MW: p=0.003
	μ ±SD	53.65 ±9.46	57.16 ±10.6	56.49 ±10.5
Etiology	alcohol	59 (56.7%)	198 (43.9%)	257 (46.3%)	V=0.26 (p<0.001)
	virus B	6 (5.8%)	14 (3.1%)	20 (3.6%)
	virus C	14 (13.5%)	136 (30.2%)	150 (27.0%)
	virus mix	0	6 (1.3%)	6 (1.1%)
	alcohol+virus	11 (10.6%)	23 (5.1%)	34 (6.1%)
	autoimmune	4 (3.8%)	26 (5.8%)	30 (5.4%)
	metabolic	1 (1.0%)	25 (5.5%)	26 (4.7%)
	hepatic venous outflow obstruction	2 (1.9%)	2 (0.4%)	4 (0.7%)
	cryptogenic	0	13 (2.9%)	13 (2.3%)
	other	7 (6.7%)	8 (1.8%)	15 (2.7%)
Cirrhosis		101 (97.1%)	449 (99.3%)	550 (98.9%)	OR=0.22 [0.04, 1.13] (p=0.083)
Decompensation		104 (100%)	262 (58.0%)	366 (65.8%)	OR=151.67 [9.37, 2 456.32] (p<0.001)
Alcoholic hepatitis		0	99 (21.9%)	99 (17.8%)	OR=0.02 [0.00, 0.28] (p<0.001)
Alc Hep responder		0	15 (3.3%)	15 (2.7%)	OR=0.14 [0.01, 2.28] (p=0.086)
HVPG value	M (min:max)	17 (10:26)	17 (10:40)	17 (10:40)	MW: p=0.679
	μ ±SD	17.03 ±3.62	17.53 ±5.11	17.44 ±4.87
PPG_aftertips	M (min:max)	7 (2:15)		7 (2:15)
	μ ±SD	7.32 ±2.62		7.32 ±2.62
Child-Pugh	1	19 (18.8%)	143 (38.0%)	162 (34.0%)	V=0.21 (p<0.001)
	2	51 (50.5%)	107 (28.5%)	158 (33.1%)
	3	31 (30.7%)	126 (33.5%)	157 (32.9%)
Platelets	M (min:max)	100 (27:547)	105.5 (21:636)	105 (21:636)	MW: p=0.176
	μ ±SD	121.01 ±83.5	128.69 ±82.4	127.25 ±82.6
HCC status		4 (3.8%)	7 (1.5%)	11 (2.0%)	OR=2.54 [0.73, 8.85] (p=0.132)
Total bilirubin	M (min:max)		2.2 (0.3:43.1)	2.2 (0.3:43.1)
	μ ±SD		6.19 ±8.47	6.19 ±8.47
Albumin	M (min:max)		3.1 (1:6.6)	3.1 (1:6.6)
	μ ±SD		3.26 ±0.743	3.26 ±0.743
INR	M (min:max)		1.47 (0.88:6.12)	1.47 (0.88:6.12)
	μ ±SD		1.64 ±0.584	1.64 ±0.584
Ascitis		0	201 (44.5%)	201 (36.2%)	OR=0.01 [0.00, 0.10] (p<0.001)
Other decompensation types	variceal bleeding	0 (NA)	24 (37.5%)	24 (37.5%)	V=NA (p>0.999)
	hepatic encephalopathy	0 (NA)	5 (7.8%)	5 (7.8%)
	jaundice	0 (NA)	33 (51.6%)	33 (51.6%)
	HCC	0 (NA)	1 (1.6%)	1 (1.6%)
	other	0 (NA)	1 (1.6%)	1 (1.6%)
ID	M (min:max)	289 (4:563)	282.5 (1:567)	285 (1:567)	MW: p=0.928
	μ ±SD	284.47 ±167.4	286.26 ±161.1	285.93 ±162.2
Column2	M (min:max)	11 (0:88)	6 (0:53)	7 (0:88)	MW: p=0.016
	μ ±SD	16.11 ±18.9	10.84 ±12.3	11.84 ±14.0
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test; OR = odds-ratio [95% CI] and p value from Fisher test); V = Cramér V (p value from Chi² test);

Table 2: .

Variable	Details	yes	no	Total	Statistics
TIPS		4 (36.4%)	7 (63.6%)	11
Column1	M (min:max)
	μ ±SD
Obs		4 (100%)	7 (100%)	11 (100%)	OR=0.60 [0.01, 35.86] (p>0.999)
months till dg	M (min:max)	19 (14:25)	7 (2:37)	13.5 (2:37)	T-test: p=0.666
	μ ±SD	19.33 ±5.51	15.14 ±15.3	16.40 ±13.0
HCC 1 an		0	4 (57.1%)	4 (36.4%)	OR=0.09 [0.00, 2.20] (p=0.194)
HCC 2 ani		2 (50.0%)	5 (71.4%)	7 (63.6%)	OR=0.40 [0.03, 5.15] (p=0.576)
HCC 3 ani		3 (75.0%)	6 (85.7%)	9 (81.8%)	OR=0.50 [0.02, 11.09] (p>0.999)
Sex	F	1 (25.0%)	2 (28.6%)	3 (27.3%)	OR=0.83 [0.05, 13.63] (p>0.999)
	M	3 (75.0%)	5 (71.4%)	8 (72.7%)
Age (years)	M (min:max)	58.5 (58:64)	57 (48:74)	58 (48:74)	T-test: p=0.606
	μ ±SD	59.75 ±2.87	57.00 ±9.85	58.00 ±7.91
Etiology	alcohol	2 (50.0%)	4 (57.1%)	6 (54.5%)	V=0.53 (p=0.380)
	virus B	1 (25.0%)	0	1 (9.1%)
	virus C	0	2 (28.6%)	2 (18.2%)
	virus mix	0	0	0
	alcohol+virus	1 (25.0%)	1 (14.3%)	2 (18.2%)
	autoimmune	0	0	0
	metabolic	0	0	0
	hepatic venous outflow obstruction	0	0	0
	cryptogenic	0	0	0
	other	0	0	0
Cirrhosis		4 (100%)	7 (100%)	11 (100%)	OR=0.60 [0.01, 35.86] (p>0.999)
Decompensation		4 (100%)	5 (71.4%)	9 (81.8%)	OR=4.09 [0.15, 108.94] (p=0.491)
Alcoholic hepatitis		0	2 (28.6%)	2 (18.2%)	OR=0.24 [0.01, 6.51] (p=0.491)
Alc Hep responder		0	2 (28.6%)	2 (18.2%)	OR=0.24 [0.01, 6.51] (p=0.491)
HVPG value	M (min:max)	18 (14:25)	19 (11:27)	19 (11:27)	T-test: p=0.944
	μ ±SD	18.75 ±5.62	19.00 ±5.51	18.91 ±5.26
PPG_aftertips	M (min:max)	7 (4:13)		7 (4:13)
	μ ±SD	7.75 ±3.86		7.75 ±3.86
Child-Pugh	1	0	2 (28.6%)	2 (18.2%)	V=0.48 (p=0.276)
	2	1 (25.0%)	3 (42.9%)	4 (36.4%)
	3	3 (75.0%)	2 (28.6%)	5 (45.5%)
Platelets	M (min:max)	51 (33:85)	55 (38:203)	52 (33:203)	MW: p=0.570
	μ ±SD	55.00 ±21.7	77.00 ±57.1	69.00 ±47.2
HCC status		4 (100%)	7 (100%)	11 (100%)	OR=0.60 [0.01, 35.86] (p>0.999)
Total bilirubin	M (min:max)		2.2 (1:25.5)	2.2 (1:25.5)
	μ ±SD		8.93 ±11.1	8.93 ±11.1
Albumin	M (min:max)		2.8 (2.6:3.4)	2.8 (2.6:3.4)
	μ ±SD		2.93 ±0.416	2.93 ±0.416
INR	M (min:max)		1.44 (1.19:1.96)	1.44 (1.19:1.96)
	μ ±SD		1.52 ±0.334	1.52 ±0.334
Ascitis		0	3 (42.9%)	3 (27.3%)	OR=0.14 [0.01, 3.64] (p=0.236)
Other decompensation types	variceal bleeding	0 (NA)	1 (50.0%)	1 (50.0%)	V=NA (p>0.999)
	hepatic encephalopathy	0 (NA)	0	0
	jaundice	0 (NA)	1 (50.0%)	1 (50.0%)
	HCC	0 (NA)	0	0
	other	0 (NA)	0	0
ID	M (min:max)	458.5 (377:559)	297 (27:471)	316 (27:559)	T-test: p=0.028
	μ ±SD	463.25 ±92.7	227.14 ±164.5	313.00 ±181.7
Column2	M (min:max)	37 (18:86)	13 (8:36)	18 (8:86)	MW: p=0.072
	μ ±SD	44.50 ±31.9	18.00 ±12.2	27.64 ±23.9
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test; OR = odds-ratio [95% CI] and p value from Fisher test); V = Cramér V (p value from Chi² test);

Welch Two Sample t-test

data: HVPG_1_luna_tips\(PPG_aftertips and HVPG_no_TIPS\)HVPG value t = -29, df = 309, p-value <0.0000000000000002 alternative hypothesis: true difference in means is not equal to 0 95 percent confidence interval: -10.90 -9.52 sample estimates: mean of x mean of y 7.32 17.53

Wilcoxon rank sum test with continuity correction

data: HVPG_1_luna_tips\(PPG_aftertips and HVPG_no_TIPS\)HVPG value W = 1064, p-value <0.0000000000000002 alternative hypothesis: true location shift is not equal to 0

Table 3: .

Variable	Details	yes	no	Total	Statistics
HCC status		11 (2.0%)	545 (98.0%)	556
Column1	M (min:max)
	μ ±SD
Obs		11 (100%)	0	11 (2.0%)	OR=10 000.00 [476.82, 10 000.00] (p<0.001)
TIPS		4 (36.4%)	100 (18.3%)	104 (18.7%)	OR=2.54 [0.73, 8.85] (p=0.132)
months till dg	M (min:max)	13.5 (2:37)		13.5 (2:37)
	μ ±SD	16.40 ±13.0		16.40 ±13.0
HCC 1 an		4 (36.4%)	0	4 (0.7%)	OR=654.60 [32.29, 10 000.00] (p<0.001)
HCC 2 ani		7 (63.6%)	0	7 (1.3%)	OR=1 818.33 [89.69, 10 000.00] (p<0.001)
HCC 3 ani		9 (81.8%)	0	9 (1.6%)	OR=4 145.80 [186.14, 10 000.00] (p<0.001)
Sex	F	3 (27.3%)	235 (43.1%)	238 (42.8%)	OR=0.49 [0.13, 1.88] (p=0.367)
	M	8 (72.7%)	310 (56.9%)	318 (57.2%)
Age (years)	M (min:max)	58 (48:74)	57 (23:87)	57 (23:87)	MW: p=0.697
	μ ±SD	58.00 ±7.91	56.46 ±10.6	56.49 ±10.5
Etiology	alcohol	6 (54.5%)	251 (46.1%)	257 (46.3%)	V=0.10 (p=0.741)
	virus B	1 (9.1%)	19 (3.5%)	20 (3.6%)
	virus C	2 (18.2%)	148 (27.2%)	150 (27.0%)
	virus mix	0	6 (1.1%)	6 (1.1%)
	alcohol+virus	2 (18.2%)	32 (5.9%)	34 (6.1%)
	autoimmune	0	30 (5.5%)	30 (5.4%)
	metabolic	0	26 (4.8%)	26 (4.7%)
	hepatic venous outflow obstruction	0	4 (0.7%)	4 (0.7%)
	cryptogenic	0	13 (2.4%)	13 (2.3%)
	other	0	15 (2.8%)	15 (2.7%)
Cirrhosis		11 (100%)	539 (98.9%)	550 (98.9%)	OR=0.28 [0.01, 5.22] (p>0.999)
Decompensation		9 (81.8%)	357 (65.5%)	366 (65.8%)	OR=2.37 [0.51, 11.08] (p=0.347)
Alcoholic hepatitis		2 (18.2%)	97 (17.8%)	99 (17.8%)	OR=1.03 [0.22, 4.83] (p>0.999)
Alc Hep responder		2 (18.2%)	13 (2.4%)	15 (2.7%)	OR=9.09 [1.79, 46.32] (p=0.032)
HVPG value	M (min:max)	19 (11:27)	17 (10:40)	17 (10:40)	MW: p=0.296
	μ ±SD	18.91 ±5.26	17.41 ±4.86	17.44 ±4.87
PPG_aftertips	M (min:max)	7 (4:13)	7 (2:15)	7 (2:15)	MW: p=0.980
	μ ±SD	7.75 ±3.86	7.30 ±2.58	7.32 ±2.62
Child-Pugh	1	2 (18.2%)	160 (34.3%)	162 (34.0%)	V=0.05 (p=0.497)
	2	4 (36.4%)	154 (33.0%)	158 (33.1%)
	3	5 (45.5%)	152 (32.6%)	157 (32.9%)
Platelets	M (min:max)	52 (33:203)	107 (21:636)	105 (21:636)	MW: p<0.001
	μ ±SD	69.00 ±47.2	128.45 ±82.8	127.25 ±82.6
Total bilirubin	M (min:max)	2.2 (1:25.5)	2.2 (0.3:43.1)	2.2 (0.3:43.1)	MW: p=0.431
	μ ±SD	8.93 ±11.1	6.15 ±8.44	6.19 ±8.47
Albumin	M (min:max)	2.8 (2.6:3.4)	3.1 (1:6.6)	3.1 (1:6.6)	MW: p=0.384
	μ ±SD	2.93 ±0.416	3.26 ±0.745	3.26 ±0.743
INR	M (min:max)	1.44 (1.19:1.96)	1.48 (0.88:6.12)	1.47 (0.88:6.12)	MW: p=0.899
	μ ±SD	1.52 ±0.334	1.64 ±0.587	1.64 ±0.584
Ascitis		3 (27.3%)	198 (36.3%)	201 (36.2%)	OR=0.66 [0.17, 2.51] (p=0.754)
Other decompensation types	variceal bleeding	1 (50.0%)	23 (37.1%)	24 (37.5%)	V=0.07 (p=0.989)
	hepatic encephalopathy	0	5 (8.1%)	5 (7.8%)
	jaundice	1 (50.0%)	32 (51.6%)	33 (51.6%)
	HCC	0	1 (1.6%)	1 (1.6%)
	other	0	1 (1.6%)	1 (1.6%)
ID	M (min:max)	316 (27:559)	282.5 (1:567)	285 (1:567)	MW: p=0.574
	μ ±SD	313.00 ±181.7	285.37 ±161.9	285.93 ±162.2
Column2	M (min:max)	18 (8:86)	6 (0:88)	7 (0:88)	MW: p=0.002
	μ ±SD	27.64 ±23.9	11.50 ±13.5	11.84 ±14.0
HVPG >= 17	[17,Inf]	7 (63.6%)	289 (53.0%)	296 (53.2%)	OR=1.55 [0.45, 5.36] (p=0.554)
	[0,17)	4 (36.4%)	256 (47.0%)	260 (46.8%)
HVPG >= 18	[18,Inf]	6 (54.5%)	251 (46.1%)	257 (46.2%)	OR=1.41 [0.42, 4.66] (p=0.762)
	[0,18)	5 (45.5%)	294 (53.9%)	299 (53.8%)
Etiologie = 1	1 (alcohol)	6 (54.5%)	251 (46.1%)	257 (46.2%)	OR=1.41 [0.42, 4.66] (p=0.762)
	2-10 (others)	5 (45.5%)	294 (53.9%)	299 (53.8%)
HVPG value >= 10	[10,Inf]	11 (100%)	545 (100%)	556 (100%)	OR=0.02 [0.00, 1.11] (p>0.999)
	[0,10)	0	0	0
HVPG value >= 11	[11,Inf]	11 (100%)	508 (93.2%)	519 (93.3%)	OR=1.70 [0.10, 29.35] (p>0.999)
	[0,11)	0	37 (6.8%)	37 (6.7%)
HVPG value >= 12	[12,Inf]	10 (90.9%)	486 (89.2%)	496 (89.2%)	OR=1.21 [0.15, 9.65] (p>0.999)
	[0,12)	1 (9.1%)	59 (10.8%)	60 (10.8%)
HVPG value >= 13	[13,Inf]	10 (90.9%)	459 (84.2%)	469 (84.4%)	OR=1.87 [0.24, 14.83] (p>0.999)
	[0,13)	1 (9.1%)	86 (15.8%)	87 (15.6%)
HVPG value >= 14	[14,Inf]	10 (90.9%)	419 (76.9%)	429 (77.2%)	OR=3.01 [0.38, 23.72] (p=0.470)
	[0,14)	1 (9.1%)	126 (23.1%)	127 (22.8%)
HVPG value >= 14.5	[14.5,Inf]	7 (63.6%)	378 (69.4%)	385 (69.2%)	OR=0.77 [0.22, 2.68] (p=0.744)
	[0,14.5)	4 (36.4%)	167 (30.6%)	171 (30.8%)
HVPG value >= 15	[15,Inf]	7 (63.6%)	377 (69.2%)	384 (69.1%)	OR=0.78 [0.23, 2.70] (p=0.745)
	[0,15)	4 (36.4%)	168 (30.8%)	172 (30.9%)
HVPG value >= 16	[16,Inf]	7 (63.6%)	345 (63.3%)	352 (63.3%)	OR=1.01 [0.29, 3.51] (p>0.999)
	[0,16)	4 (36.4%)	200 (36.7%)	204 (36.7%)
HVPG value >= 17	[17,Inf]	7 (63.6%)	289 (53.0%)	296 (53.2%)	OR=1.55 [0.45, 5.36] (p=0.554)
	[0,17)	4 (36.4%)	256 (47.0%)	260 (46.8%)
HVPG value >= 18	[18,Inf]	6 (54.5%)	251 (46.1%)	257 (46.2%)	OR=1.41 [0.42, 4.66] (p=0.762)
	[0,18)	5 (45.5%)	294 (53.9%)	299 (53.8%)
HVPG value >= 19	[19,Inf]	6 (54.5%)	212 (38.9%)	218 (39.2%)	OR=1.88 [0.57, 6.25] (p=0.355)
	[0,19)	5 (45.5%)	333 (61.1%)	338 (60.8%)
HVPG value >= 20	[20,Inf]	5 (45.5%)	169 (31.0%)	174 (31.3%)	OR=1.85 [0.56, 6.16] (p=0.332)
	[0,20)	6 (54.5%)	376 (69.0%)	382 (68.7%)
HVPG value >= 21	[21,Inf]	5 (45.5%)	128 (23.5%)	133 (23.9%)	OR=2.71 [0.82, 9.04] (p=0.144)
	[0,21)	6 (54.5%)	417 (76.5%)	423 (76.1%)
HVPG value >= 22	[22,Inf]	5 (45.5%)	100 (18.3%)	105 (18.9%)	OR=3.71 [1.11, 12.39] (p=0.039)
	[0,22)	6 (54.5%)	445 (81.7%)	451 (81.1%)
HVPG value >= 23	[23,Inf]	3 (27.3%)	72 (13.2%)	75 (13.5%)	OR=2.46 [0.64, 9.50] (p=0.175)
	[0,23)	8 (72.7%)	473 (86.8%)	481 (86.5%)
HVPG value >= 24	[24,Inf]	2 (18.2%)	57 (10.5%)	59 (10.6%)	OR=1.90 [0.40, 9.02] (p=0.329)
	[0,24)	9 (81.8%)	488 (89.5%)	497 (89.4%)
HVPG value >= 25	[25,Inf]	2 (18.2%)	39 (7.2%)	41 (7.4%)	OR=2.88 [0.60, 13.81] (p=0.191)
	[0,25)	9 (81.8%)	506 (92.8%)	515 (92.6%)
HVPG value >= 26	[26,Inf]	1 (9.1%)	32 (5.9%)	33 (5.9%)	OR=1.60 [0.20, 12.91] (p=0.493)
	[0,26)	10 (90.9%)	513 (94.1%)	523 (94.1%)
HVPG value >= 27	[27,Inf]	1 (9.1%)	23 (4.2%)	24 (4.3%)	OR=2.27 [0.28, 18.49] (p=0.387)
	[0,27)	10 (90.9%)	522 (95.8%)	532 (95.7%)
HVPG value >= 28	[28,Inf]	0	20 (3.7%)	20 (3.6%)	OR=1.11 [0.06, 19.57] (p>0.999)
	[0,28)	11 (100%)	525 (96.3%)	536 (96.4%)
HVPG value >= 29	[29,Inf]	0	11 (2.0%)	11 (2.0%)	OR=2.02 [0.11, 36.40] (p>0.999)
	[0,29)	11 (100%)	534 (98.0%)	545 (98.0%)
HVPG value >= 30	[30,Inf]	0	10 (1.8%)	10 (1.8%)	OR=2.22 [0.12, 40.16] (p>0.999)
	[0,30)	11 (100%)	535 (98.2%)	546 (98.2%)
HVPG value >= 31	[31,Inf]	0	8 (1.5%)	8 (1.4%)	OR=2.75 [0.15, 50.54] (p>0.999)
	[0,31)	11 (100%)	537 (98.5%)	548 (98.6%)
HVPG value >= 32	[32,Inf]	0	7 (1.3%)	7 (1.3%)	OR=3.12 [0.17, 57.98] (p>0.999)
	[0,32)	11 (100%)	538 (98.7%)	549 (98.7%)
HVPG value >= 35	[35,Inf]	0	3 (0.6%)	3 (0.5%)	OR=6.74 [0.33, 138.12] (p>0.999)
	[0,35)	11 (100%)	542 (99.4%)	553 (99.5%)
HVPG value >= 40	[40,Inf]	0	1 (0.2%)	1 (0.2%)	OR=15.78 [0.61, 408.45] (p>0.999)
	[0,40)	11 (100%)	544 (99.8%)	555 (99.8%)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test; OR = odds-ratio [95% CI] and p value from Fisher test); V = Cramér V (p value from Chi² test);

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