Article

Article

https://rpubs.com/alex_istrate/611591

0.1 Methods

0.1.1 Statisitcal analysis of the data

To describe the quantitative variables, we used histograms and we calculated the arithmetic means ±standard deviation (SD) [with 95% confidence interval (CI)], as well as the extreme and median values. For the qualitative variables, we used pie or bar charts and calculated the absolute and percentual frequencies of the formed categories.

To study the relationships between quantitative and qualitative variables, we used the T or Mann-Whitney (MW) tests if they were binary, respectively ANOVA or Kruskal-Wallis (KW) if they had more categories. We presented the p values generated by these tests as well as the means ±SD of the groups and the difference of the means with associated 95% CI. We graphically presented the results in the form of box plots. To study the relationships between the quantitative variables we used the Spearman correlation coefficient (R), with the associated p-value and graphically presented the relations as scatter plots, on which we added the regression line. To describe the relationships between the qualitative variables we used the Chi² or Fisher test and the Cramer phi or V and Odds-Ratio (OR) / Relative Risk (RR) indicators with 95% CI. We graphically presented the results in the form of pie or bar charts.

We used WPS Office 2019 for database management. For all statistical analyzes and subsequent graphs we used R 4.0.0 [1]. We considered p <0.05 to be statistically significant and p <0.10 to show only a tendency towards statistical significance.

0.2 Results

0.2.1 Demographics

Table 1: Demographic parameters of the sample.

Variable	Details	Total
N=		45
Group	HD	21 (46.7%)
	PD	24 (53.3%)
Age (years)	μ ±SD	12.80 ±4.51
	M (min:max)	14 (2:17)
Sex	F	9 (60.0%)
	M	6 (40.0%)
County	AB	1 (6.7%)
	BH	2 (13.3%)
	BV	1 (6.7%)
	CJ	1 (6.7%)
	HD	2 (13.3%)
	MM	1 (6.7%)
	MS	1 (6.7%)
	SB	2 (13.3%)
	SM	1 (6.7%)
	SV	1 (6.7%)
	VL	2 (13.3%)
Environment	rural	9 (60.0%)
	urban	6 (40.0%)
Etiology	acquired	5 (33.3%)
	congenital	6 (40.0%)
	genetic	4 (26.7%)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

Figure 1: Sex distribution.

Figure 2: Etiology.

Figure 3: Age distribution, at first examination, colored by sex. (| mean, ¦ median).

0.2.2 Laboratory values

Table 2: Laboratory parameters of the sample.

Variable	Details	1	2	3	Total	Statistics
Sample ID		15 (33.3%)	15 (33.3%)	15 (33.3%)	45
RBC (x10*6/μl)	μ ±SD	3.79 ±0.676	4.17 ±0.681	3.82 ±0.697	3.93 ±0.691	Friedman test: p=0.002
	M (min:max)	3.87 (2.4:5.43)	3.96 (3.23:5.47)	3.72 (2.76:5.38)	3.9 (2.4:5.47)
Hemoglobin (g/dl)	μ ±SD	10.79 ±1.56	12.21 ±1.54	10.19 ±3.0	11.11 ±2.21	Friedman test: p=0.020
	M (min:max)	11.3 (6.8:13.3)	12 (8.7:15.3)	10.9 (1.41:14)	11.4 (1.41:15.3)
Eosinophiles (%)	μ ±SD	5.13 ±4.11	5.37 ±4.04	4.35 ±4.33	4.98 ±4.08	Friedman test: p=0.199
	M (min:max)	3.9 (0.2:15.6)	4 (1.7:14.7)	2.9 (0.9:17.3)	3.8 (0.2:17.3)
WBC (x10*3/μl)	μ ±SD	7.59 ±2.07	7.90 ±2.84	8.84 ±1.92	8.08 ±2.33	Friedman test: p=0.735
	M (min:max)	7.65 (3.56:10.88)	8.4 (2.77:13.98)	8.33 (6.84:14.03)	8.26 (2.77:14.03)
Platelets (x10*3/μl)	μ ±SD	251.47 ±89.7	265.73 ±84.0	276.92 ±82.1	264.14 ±84.1	Friedman test: p=0.735
	M (min:max)	236 (111:467)	253 (155:440)	296 (140:412)	253 (111:467)
Blood iron (mg/dl)	μ ±SD	92.69 ±46.4	78.74 ±47.4	76.91 ±37.7	83.47 ±43.7	Friedman test: p=0.761
	M (min:max)	92.95 (29.3:214.1)	79.15 (11.4:186.9)	74.3 (20.4:128)	88 (11.4:214.1)
Ferritin (ng/ml)	μ ±SD	574.75 ±964.9	585.47 ±464.6	425.24 ±293.1	525.89 ±648.1	Friedman test: p=0.565
	M (min:max)	143.5 (7.52:3200.1)	377.6 (49.2:1425.2)	474 (24.3:766.8)	370.85 (7.52:3200.1)
Transferrin (mg/dl)	μ ±SD	223.03 ±59.7	220.14 ±63.1	208.07 ±59.9	217.66 ±59.3	Friedman test: p=0.368
	M (min:max)	225.9 (161.8:380.8)	191.1 (155:317.5)	180.3 (150.6:315)	191.55 (150.6:380.8)
Total Ca (mg/dl)	μ ±SD	8.70 ±0.976	8.95 ±1.48	8.49 ±1.24	8.72 ±1.24	Friedman test: p=0.584
	M (min:max)	8.71 (6.66:9.99)	8.87 (6.12:12.8)	8.82 (5.78:9.83)	8.82 (5.78:12.8)
Ionized Ca (mmoli/l)	μ ±SD	1.05 ±0.119	1.14 ±0.25	1.04 ±0.129	1.08 ±0.18	Friedman test: p=0.451
	M (min:max)	1.04 (0.9:1.32)	1.15 (0.78:1.78)	1.06 (0.79:1.22)	1.06 (0.78:1.78)
Mg (mg/dl)	μ ±SD	3.01 ±0.441	3.00 ±0.461	3.13 ±0.537	3.04 ±0.471	Friedman test: p=0.368
	M (min:max)	3.08 (2.12:3.68)	3.1 (2.1:3.89)	3.15 (2.14:4.14)	3.09 (2.1:4.14)
P ( mg/dl)	μ ±SD	5.11 ±1.37	5.37 ±1.1	4.90 ±1.1	5.14 ±1.19	Friedman test: p=0.484
	M (min:max)	5.5 (2.34:7.34)	5.2 (3.74:7.18)	4.65 (3.37:6.87)	5.2 (2.34:7.34)
PTH (pg/ml)	μ ±SD	736.24 ±669.1	796.86 ±519.9	694.24 ±605.7	740.77 ±592.9	Friedman test: p=0.862
	M (min:max)	610.6 (3.8:2411)	689.25 (20.3:1946.5)	558.6 (21.6:2000)	599.9 (3.8:2411)
ALP (IU/L)	μ ±SD	427.00 ±284.3	523.86 ±333.4	502.62 ±279.0	482.69 ±295.8	Friedman test: p=0.146
	M (min:max)	363 (56:965)	441 (66:1301)	487 (78:1102)	429 (56:1301)
Vitamine D (ng/ml)	μ ±SD	12.50 ±NA	17.00 ±NA	15.59 ±9.42	15.40 ±8.24	1-way ANOVA: p=0.939
	M (min:max)	12.5 (12.5:12.5)	17 (17:17)	14.4 (2.1:29.2)	14.4 (2.1:29.2)
Urea (mg/dl)	μ ±SD	100.27 ±27.1	109.07 ±28.6	122.92 ±34.9	110.19 ±30.8	Friedman test: p=0.037
	M (min:max)	92 (60:156)	100 (73:169)	113 (85:189)	100 (60:189)
Creatinine (mg/dl)	μ ±SD	7.27 ±3.23	8.30 ±4.22	7.77 ±3.96	7.78 ±3.75	Friedman test: p=0.232
	M (min:max)	7.2 (1.49:13.25)	7 (1.78:16.01)	7.66 (1.67:15.54)	7.2 (1.49:16.01)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test; Welch = Welch T-Test (not assuming equal variances); OR/RR = odds-ratio / risk-ratio [95% CI] and p value from Fisher test); V = Cramér V (p value from Chi² test);

Table 2: Laboratory parameters of the sample.

Variable	Details	1	2	3	Total	Statistics
Sample ID		15 (33.3%)	15 (33.3%)	15 (33.3%)	45
RBC (x10*6/μl) groups	low	7 (46.7%)	4 (26.7%)	7 (53.8%)	18 (41.9%)	V=0.19 (p=0.544)
	normal	7 (46.7%)	8 (53.3%)	5 (38.5%)	20 (46.5%)
	high	1 (6.7%)	3 (20.0%)	1 (7.7%)	5 (11.6%)
Hemoglobin (g/dl) groups	low	11 (73.3%)	6 (40.0%)	10 (76.9%)	27 (62.8%)	V=0.27 (p=0.195)
	normal	4 (26.7%)	8 (53.3%)	3 (23.1%)	15 (34.9%)
	high	0	1 (6.7%)	0	1 (2.3%)
Eosinophiles (%) groups	normal	10 (66.7%)	12 (80.0%)	12 (92.3%)	34 (79.1%)	V=0.25 (p=0.249)
	high	5 (33.3%)	3 (20.0%)	1 (7.7%)	9 (20.9%)
WBC (x10*3/μl) groups	low	1 (6.7%)	2 (13.3%)	0	3 (7.0%)	V=0.19 (p=0.550)
	normal	14 (93.3%)	12 (80.0%)	12 (92.3%)	38 (88.4%)
	high	0	1 (6.7%)	1 (7.7%)	2 (4.7%)
Platelets (x10*3/μl) groups	low	1 (6.7%)	0	2 (15.4%)	3 (7.0%)	V=0.23 (p=0.348)
	normal	13 (86.7%)	15 (100%)	11 (84.6%)	39 (90.7%)
	high	1 (6.7%)	0	0	1 (2.3%)
Blood iron (mg/dl) groups	low	3 (21.4%)	2 (16.7%)	2 (18.2%)	7 (18.9%)	V=0.12 (p=0.905)
	normal	10 (71.4%)	9 (75.0%)	9 (81.8%)	28 (75.7%)
	high	1 (7.1%)	1 (8.3%)	0	2 (5.4%)
Transferrin (mg/dl) groups	low	6 (40.0%)	5 (50.0%)	7 (63.6%)	18 (50.0%)	V=0.20 (p=0.492)
	normal	9 (60.0%)	5 (50.0%)	4 (36.4%)	18 (50.0%)
	high	0	0	0	0
Total Ca (mg/dl) groups	low	6 (40.0%)	6 (40.0%)	5 (38.5%)	17 (39.5%)	V=0.22 (p=0.394)
	normal	9 (60.0%)	7 (46.7%)	8 (61.5%)	24 (55.8%)
	high	0	2 (13.3%)	0	2 (4.7%)
Ionized Ca (mmoli/l) groups	low	12 (80.0%)	8 (53.3%)	10 (76.9%)	30 (69.8%)	V=0.23 (p=0.314)
	normal	2 (13.3%)	4 (26.7%)	3 (23.1%)	9 (20.9%)
	high	1 (6.7%)	3 (20.0%)	0	4 (9.3%)
Mg (mg/dl) groups	low	0	0	0	0	V=0.02 (p=0.993)
	normal	1 (6.7%)	1 (6.7%)	1 (7.7%)	3 (7.0%)
	high	14 (93.3%)	14 (93.3%)	12 (92.3%)	40 (93.0%)
P ( mg/dl) groups	low	1 (6.7%)	0	0	1 (2.3%)	V=0.18 (p=0.590)
	normal	5 (33.3%)	7 (46.7%)	7 (53.8%)	19 (44.2%)
	high	9 (60.0%)	8 (53.3%)	6 (46.2%)	23 (53.5%)
PTH (pg/ml) groups	low	2 (13.3%)	0	0	2 (5.0%)	V=0.22 (p=0.408)
	normal	2 (13.3%)	1 (8.3%)	1 (7.7%)	4 (10.0%)
	high	11 (73.3%)	11 (91.7%)	12 (92.3%)	34 (85.0%)
ALP (IU/L) groups	very low	0	0	0	0	V=0.14 (p=0.650)
	low	0	0	0	0
	optimal	3 (20.0%)	2 (14.3%)	1 (7.7%)	6 (14.3%)
	high	0	0	0	0
	very high	12 (80.0%)	12 (85.7%)	12 (92.3%)	36 (85.7%)
Vitamine D (ng/ml) groups	very low	0	0	2 (28.6%)	2 (22.2%)	V=0.29 (p=0.693)
	low	1 (100%)	1 (100%)	5 (71.4%)	7 (77.8%)
	normal	0	0	0	0
Urea (mg/dl) groups	low	0	0	0	0	V=NA (p>0.999)
	normal	0	0	0	0
	high	15 (100%)	15 (100%)	13 (100%)	43 (100%)
Creatinine (mg/dl) groups	low	0	0	0	0	V=NA (p>0.999)
	normal	0	0	0	0
	high	15 (100%)	15 (100%)	13 (100%)	43 (100%)
Ferritin (ng/ml) groups	low	1 (10.0%)	0	0	1 (3.8%)	V=0.24 (p=0.544)
	normal	5 (50.0%)	2 (28.6%)	3 (33.3%)	10 (38.5%)
	high	4 (40.0%)	5 (71.4%)	6 (66.7%)	15 (57.7%)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test; Welch = Welch T-Test (not assuming equal variances); OR/RR = odds-ratio / risk-ratio [95% CI] and p value from Fisher test); V = Cramér V (p value from Chi² test);

0.2.3 Metals

Table 3: Metals (pre-dialysis blood).

Variable	Details	1	2	3	Total	Statistics
Sample ID		15 (33.3%)	15 (33.3%)	15 (33.3%)	45
Al (mg/kg) pre-dialysis blood	μ ±SD	1.10 ±1.09	4.09 ±11.1	0.916 ±0.344	2.04 ±6.42	Friedman test: p=0.086
	M (min:max)	0.72 (0.33:4.25)	0.93 (0.52:40.83)	0.71 (0.55:1.52)	0.8 (0.33:40.83)
Cu (mg/kg) pre-dialysis blood	μ ±SD	0.953 ±0.478	0.843 ±0.589	0.529 ±0.165	0.797 ±0.481	Friedman test: p=0.020
	M (min:max)	0.9 (0.4:2.35)	0.75 (0.33:2.64)	0.55 (0.27:0.78)	0.72 (0.27:2.64)
Fe (mg/kg) pre-dialysis blood	μ ±SD	38.58 ±61.5	116.50 ±183.3	19.69 ±37.2	59.22 ±118.8	Friedman test: p=0.013
	M (min:max)	24.21 (4:254.03)	21.95 (0.53:531.17)	7.08 (1.42:129.7)	15.8 (0.53:531.17)
Zn (mg/kg) pre-dialysis blood	μ ±SD	15.11 ±46.3	4.87 ±5.82	3.17 ±3.07	8.33 ±28.9	Friedman test: p=0.913
	M (min:max)	2.13 (0.97:182.28)	2.22 (1.2:22.08)	2.39 (1.4:12.19)	2.21 (0.97:182.28)
K (mg/kg) pre-dialysis blood	μ ±SD	164.52 ±73.4	682.24 ±1033.3	229.51 ±204.8	355.42 ±636.9	Friedman test: p=0.060
	M (min:max)	164.42 (12.41:348.03)	199.97 (147.96:3023.41)	173.87 (129.53:840.54)	179.92 (12.41:3023.41)
Na (mg/kg) pre-dialysis blood	μ ±SD	605.61 ±417.9	731.50 ±1301.6	192.23 ±392.7	534.71 ±819.6	Friedman test: p=0.032
	M (min:max)	664.2 (31.81:1334.48)	105.93 (22:4069.4)	88.47 (8.21:1302.28)	115.38 (8.21:4069.4)
Pb (mg/kg) pre-dialysis blood	μ ±SD	0.317 ±0.204	0.295 ±0.194	0.28 ±0.0896	0.295 ±0.162	Friedman test: p=0.368
	M (min:max)	0.24 (0.07:0.67)	0.27 (0.1:0.86)	0.28 (0.13:0.41)	0.27 (0.07:0.86)
Cd (mg/kg) pre-dialysis blood	μ ±SD	0.156 ±0.098	0.224 ±0.125	0.218 ±0.0701	0.205 ±0.103	Friedman test: p=0.472
	M (min:max)	0.16 (0.02:0.34)	0.22 (0.06:0.58)	0.22 (0.06:0.32)	0.21 (0.02:0.58)
Ni (mg/kg) pre-dialysis blood	μ ±SD	0.21 ±0.213	0.405 ±0.279	0.306 ±0.118	0.319 ±0.226	Friedman test: p=0.549
	M (min:max)	0.18 (0.01:0.7)	0.4 (0.08:0.98)	0.3 (0.08:0.49)	0.28 (0.01:0.98)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test;

Table 4: Metals (post-dialysis blood).

Variable	Details	1	2	3	Total	Statistics
Sample ID		15 (33.3%)	15 (33.3%)	15 (33.3%)	45
Al (mg/kg) post-dialysis blood	μ ±SD	0.692 ±0.378	1.88 ±2.16	1.01 ±0.484	1.21 ±1.4	Friedman test: p=0.247
	M (min:max)	0.5 (0.36:1.27)	0.91 (0.53:6.58)	0.94 (0.52:1.74)	0.76 (0.36:6.58)
Cu (mg/kg) post-dialysis blood	μ ±SD	0.33 ±0.148	0.561 ±0.187	0.529 ±0.0934	0.467 ±0.181	Friedman test: p=0.247
	M (min:max)	0.33 (0.11:0.49)	0.48 (0.4:0.92)	0.52 (0.43:0.62)	0.46 (0.11:0.92)
Fe (mg/kg) post-dialysis blood	μ ±SD	81.17 ±59.4	5.41 ±2.62	3.16 ±1.43	32.73 ±51.2	Friedman test: p=0.022
	M (min:max)	66.89 (7.06:161.71)	4.53 (2.1:9.33)	2.7 (2.08:5.67)	6.4 (2.08:161.71)
Zn (mg/kg) post-dialysis blood	μ ±SD	2.99 ±2.33	4.77 ±3.34	5.25 ±2.79	4.24 ±2.87	Friedman test: p=0.247
	M (min:max)	2.28 (1.38:8.11)	3.97 (0.96:11.83)	5.74 (1.18:8.42)	3.94 (0.96:11.83)
K (mg/kg) post-dialysis blood	μ ±SD	141.10 ±31.5	160.41 ±25.2	164.22 ±13.4	154.30 ±26.3	Friedman test: p=0.549
	M (min:max)	138.19 (85.27:186.26)	152.36 (131.32:203.74)	159.61 (152.3:187.26)	152.36 (85.27:203.74)
Na (mg/kg) post-dialysis blood	μ ±SD	435.88 ±211.0	78.05 ±24.5	85.75 ±21.5	211.91 ±214.6	Friedman test: p=0.022
	M (min:max)	451.02 (52.42:697.21)	73.57 (48.28:116.51)	78.16 (70.52:122.24)	86.92 (48.28:697.21)
Pb (mg/kg) post-dialysis blood	μ ±SD	0.318 ±NA	0.328 ±0.041	0.338 ±0.0385	0.331 ±0.0371	1-way ANOVA: p=0.851
	M (min:max)	0.32 (0.32:0.32)	0.32 (0.29:0.4)	0.34 (0.29:0.39)	0.32 (0.29:0.4)
Cd (mg/kg) post-dialysis blood	μ ±SD	0.205 ±NA	0.238 ±0.0374	0.249 ±0.0238	0.239 ±0.032	KW: p=0.220
	M (min:max)	0.2 (0.2:0.2)	0.22 (0.21:0.31)	0.24 (0.22:0.29)	0.24 (0.2:0.31)
Ni (mg/kg) post-dialysis blood	μ ±SD	0.393 ±NA	0.369 ±0.104	0.321 ±0.0406	0.352 ±0.0814	1-way ANOVA: p=0.572
	M (min:max)	0.39 (0.39:0.39)	0.34 (0.26:0.52)	0.31 (0.29:0.39)	0.32 (0.26:0.52)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test;

Table 5: Metals (urine).

Variable	Details	1	2	3	Total	Statistics
Sample ID		15 (33.3%)	15 (33.3%)	15 (33.3%)	45
Al (mg/kg) urine	μ ±SD	22.63 ±24.2			22.63 ±24.2
	M (min:max)	23.42 (0.17:64.23)			23.42 (0.17:64.23)
Cu (mg/kg) urine	μ ±SD	4.39 ±4.84			4.39 ±4.84
	M (min:max)	1.83 (0.23:11.28)			1.83 (0.23:11.28)
Fe (mg/kg) urine	μ ±SD	22.74 ±23.5			22.74 ±23.5
	M (min:max)	20.28 (0.17:58.05)			20.28 (0.17:58.05)
Zn (mg/kg) urine	μ ±SD	17.04 ±19.6			17.04 ±19.6
	M (min:max)	15.28 (0.53:52.13)			15.28 (0.53:52.13)
K (mg/kg) urine	μ ±SD	7946.63 ±12313.7			7946.63 ±12313.7
	M (min:max)	2989.2 (49.87:34675.93)			2989.2 (49.87:34675.93)
Na (mg/kg) urine	μ ±SD	27426.73 ±38107.7			27426.73 ±38107.7
	M (min:max)	13018.29 (68.03:94259.26)			13018.29 (68.03:94259.26)
Ni (mg/kg) urine	μ ±SD	0.334 ±0.431			0.334 ±0.431
	M (min:max)	0.21 (0:0.91)			0.21 (0:0.91)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test;

Table 6: Al (mg/kg) pre-dialysis blood: RM-ANOVA model sohwing differences between groups, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	0.82		0..388	0..03
group	9.26		0..014	0..23
sample	1.91	0.55	0..198	0..13
group x sample	1.08	0.55	0..331	0..08

Table 7: Al (mg/kg): RM-ANOVA model sohwing differences between pre- and post-dialysis blood, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	11.13		0..029	0..31
material	23.34		0..008	0..24
sample	7.14	0.91	0..021	0..39
sample x material	0.58	0.75	0..545	0..06

Table 8: Cu (mg/kg) pre-dialysis blood: RM-ANOVA model sohwing differences between groups, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	28.73		0..000	0..48
group	0.70		0..424	0..02
sample	6.22	0.66	0..022	0..33
group x sample	2.10	0.66	0..172	0..14

Table 9: Cu (mg/kg): RM-ANOVA model sohwing differences between pre- and post-dialysis blood, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	145.66		0..000	0..76
material	10.77		0..030	0..42
sample	0.53	0.55	0..521	0..04
sample x material	10.70	0.96	0..006	0..49

Table 10: Fe (mg/kg) pre-dialysis blood: RM-ANOVA model sohwing differences between groups, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	108.68		0..000	0..83
group	0.02		0..886	0..00
sample	3.44	0.72	0..075	0..19
group x sample	2.42	0.72	0..137	0..14

Table 11: Fe (mg/kg): RM-ANOVA model sohwing differences between pre- and post-dialysis blood, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	534.73		0..000	0..94
material	6.99		0..057	0..17
sample	27.65	0.55	0..004	0..74
sample x material	5.79	0.86	0..036	0..33

Table 12: Zn (mg/kg) pre-dialysis blood: RM-ANOVA model sohwing differences between groups, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	165.49		0..000	0..78
group	17.38		0..002	0..27
sample	0.63	0.88	0..527	0..05
group x sample	4.46	0.88	0..033	0..29

Table 13: Zn (mg/kg): RM-ANOVA model sohwing differences between pre- and post-dialysis blood, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	100.91		0..001	0..78
material	7.78		0..049	0..25
sample	0.25	0.64	0..693	0..02
sample x material	2.94	0.67	0..142	0..18

Table 14: K (mg/kg) pre-dialysis blood: RM-ANOVA model sohwing differences between groups, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	1050.38		0..000	0..98
group	1.06		0..329	0..05
sample	6.47	0.74	0..016	0..27
group x sample	5.76	0.74	0..022	0..25

Table 15: K (mg/kg): RM-ANOVA model sohwing differences between pre- and post-dialysis blood, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	23096.43		0..000	0.1.00
material	5.38		0..081	0..16
sample	3.66	0.58	0..118	0..12
sample x material	0.34	0.52	0..600	0..04

Table 16: Na (mg/kg) pre-dialysis blood: RM-ANOVA model sohwing differences between groups, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	627.07		0..000	0..97
group	1.98		0..202	0..09
sample	11.26	0.59	0..008	0..51
group x sample	9.43	0.59	0..013	0..47

Table 17: Na (mg/kg): RM-ANOVA model sohwing differences between pre- and post-dialysis blood, adjusted by sample.

Predictor	F	Epsilon	p	ges
(Intercept)	4176.24		0..000	0..99
material	0.46		0..534	0..03
sample	51.97	0.57	0..001	0..84
sample x material	4.90	0.77	0..059	0..21

0.2.4 Metals (pre-dialysis blood)

VS. (Spearman R)	Al (mg/kg) pre-dialysis blood	Cu (mg/kg) pre-dialysis blood	Fe (mg/kg) pre-dialysis blood	Zn (mg/kg) pre-dialysis blood	K (mg/kg) pre-dialysis blood	Na (mg/kg) pre-dialysis blood	Pb (mg/kg) pre-dialysis blood	Cd (mg/kg) pre-dialysis blood	Ni (mg/kg) pre-dialysis blood
Al (mg/kg) pre-dialysis blood	(p<0.001)	-0.086 (p=0.600)	-0.132 (p=0.421)	0.351 (p=0.029)	0.256 (p=0.116)	-0.188 (p=0.263)	0.217 (p=0.240)	0.172 (p=0.347)	0.181 (p=0.312)
Cu (mg/kg) pre-dialysis blood	-0.086 (p=0.600)	(p<0.001)	0.504 (p=0.001)	0.298 (p=0.066)	0.462 (p=0.003)	0.703 (p<0.001)	0.320 (p=0.080)	0.136 (p=0.459)	0.085 (p=0.640)
Fe (mg/kg) pre-dialysis blood	-0.132 (p=0.421)	0.504 (p=0.001)	(p<0.001)	0.181 (p=0.269)	0.536 (p<0.001)	0.578 (p<0.001)	-0.144 (p=0.441)	-0.147 (p=0.421)	0.086 (p=0.633)
Zn (mg/kg) pre-dialysis blood	0.351 (p=0.029)	0.298 (p=0.066)	0.181 (p=0.269)	(p<0.001)	0.376 (p=0.019)	0.240 (p=0.152)	-0.104 (p=0.578)	-0.049 (p=0.788)	0.010 (p=0.956)
K (mg/kg) pre-dialysis blood	0.256 (p=0.116)	0.462 (p=0.003)	0.536 (p<0.001)	0.376 (p=0.019)	(p<0.001)	0.304 (p=0.067)	0.090 (p=0.631)	0.261 (p=0.150)	0.396 (p=0.023)
Na (mg/kg) pre-dialysis blood	-0.188 (p=0.263)	0.703 (p<0.001)	0.578 (p<0.001)	0.240 (p=0.152)	0.304 (p=0.067)	(p<0.001)	-0.043 (p=0.823)	-0.313 (p=0.092)	-0.360 (p=0.048)
Pb (mg/kg) pre-dialysis blood	0.217 (p=0.240)	0.320 (p=0.080)	-0.144 (p=0.441)	-0.104 (p=0.578)	0.090 (p=0.631)	-0.043 (p=0.823)	(p<0.001)	0.712 (p<0.001)	0.605 (p<0.001)
Cd (mg/kg) pre-dialysis blood	0.172 (p=0.347)	0.136 (p=0.459)	-0.147 (p=0.421)	-0.049 (p=0.788)	0.261 (p=0.150)	-0.313 (p=0.092)	0.712 (p<0.001)	(p<0.001)	0.928 (p<0.001)
Ni (mg/kg) pre-dialysis blood	0.181 (p=0.312)	0.085 (p=0.640)	0.086 (p=0.633)	0.010 (p=0.956)	0.396 (p=0.023)	-0.360 (p=0.048)	0.605 (p<0.001)	0.928 (p<0.001)	(p<0.001)

0.2.5 Metals (post-dialysis blood)

VS. (Spearman R)	Al (mg/kg) post-dialysis blood	Cu (mg/kg) post-dialysis blood	Fe (mg/kg) post-dialysis blood	Zn (mg/kg) post-dialysis blood	K (mg/kg) post-dialysis blood	Na (mg/kg) post-dialysis blood	Pb (mg/kg) post-dialysis blood	Cd (mg/kg) post-dialysis blood	Ni (mg/kg) post-dialysis blood
Al (mg/kg) post-dialysis blood	(p<0.001)	0.603 (p=0.006)	-0.442 (p=0.060)	0.425 (p=0.071)	0.461 (p=0.048)	-0.404 (p=0.088)	0.176 (p=0.564)	0.275 (p=0.363)	0.465 (p=0.109)
Cu (mg/kg) post-dialysis blood	0.603 (p=0.006)	(p<0.001)	-0.324 (p=0.176)	0.632 (p=0.004)	0.356 (p=0.134)	-0.147 (p=0.549)	0.825 (p<0.001)	0.649 (p=0.016)	0.824 (p<0.001)
Fe (mg/kg) post-dialysis blood	-0.442 (p=0.060)	-0.324 (p=0.176)	(p<0.001)	-0.465 (p=0.047)	-0.300 (p=0.211)	0.612 (p=0.006)	0.113 (p=0.713)	-0.225 (p=0.459)	0.421 (p=0.152)
Zn (mg/kg) post-dialysis blood	0.425 (p=0.071)	0.632 (p=0.004)	-0.465 (p=0.047)	(p<0.001)	0.360 (p=0.131)	-0.211 (p=0.385)	0.658 (p=0.014)	0.297 (p=0.325)	0.627 (p=0.022)
K (mg/kg) post-dialysis blood	0.461 (p=0.048)	0.356 (p=0.134)	-0.300 (p=0.211)	0.360 (p=0.131)	(p<0.001)	0.028 (p=0.911)	0.518 (p=0.070)	0.901 (p<0.001)	0.531 (p=0.062)
Na (mg/kg) post-dialysis blood	-0.404 (p=0.088)	-0.147 (p=0.549)	0.612 (p=0.006)	-0.211 (p=0.385)	0.028 (p=0.911)	(p<0.001)	0.782 (p=0.002)	0.593 (p=0.036)	0.421 (p=0.152)
Pb (mg/kg) post-dialysis blood	0.176 (p=0.564)	0.825 (p<0.001)	0.113 (p=0.713)	0.658 (p=0.014)	0.518 (p=0.070)	0.782 (p=0.002)	(p<0.001)	0.598 (p=0.031)	0.739 (p=0.004)
Cd (mg/kg) post-dialysis blood	0.275 (p=0.363)	0.649 (p=0.016)	-0.225 (p=0.459)	0.297 (p=0.325)	0.901 (p<0.001)	0.593 (p=0.036)	0.598 (p=0.031)	(p<0.001)	0.556 (p=0.049)
Ni (mg/kg) post-dialysis blood	0.465 (p=0.109)	0.824 (p<0.001)	0.421 (p=0.152)	0.627 (p=0.022)	0.531 (p=0.062)	0.421 (p=0.152)	0.739 (p=0.004)	0.556 (p=0.049)	(p<0.001)

0.2.6 Metals (urine)

VS. (Spearman R)	Al (mg/kg) urine	Cu (mg/kg) urine	Fe (mg/kg) urine	Zn (mg/kg) urine	K (mg/kg) urine	Na (mg/kg) urine	Ni (mg/kg) urine
Al (mg/kg) urine	(p<0.001)	0.786 (p=0.048)	0.893 (p=0.012)	0.857 (p=0.024)	0.679 (p=0.110)	0.357 (p=0.444)	0.800 (p=0.333)
Cu (mg/kg) urine	0.786 (p=0.048)	(p<0.001)	0.821 (p=0.034)	0.929 (p=0.007)	0.571 (p=0.200)	0.143 (p=0.783)	0.800 (p=0.333)
Fe (mg/kg) urine	0.893 (p=0.012)	0.821 (p=0.034)	(p<0.001)	0.857 (p=0.024)	0.500 (p=0.267)	0.071 (p=0.906)	0.800 (p=0.333)
Zn (mg/kg) urine	0.857 (p=0.024)	0.929 (p=0.007)	0.857 (p=0.024)	(p<0.001)	0.571 (p=0.200)	0.071 (p=0.906)	1.000 (p=0.083)
K (mg/kg) urine	0.679 (p=0.110)	0.571 (p=0.200)	0.500 (p=0.267)	0.571 (p=0.200)	(p<0.001)	0.821 (p=0.034)	1.000 (p=0.083)
Na (mg/kg) urine	0.357 (p=0.444)	0.143 (p=0.783)	0.071 (p=0.906)	0.071 (p=0.906)	0.821 (p=0.034)	(p<0.001)	0.600 (p=0.417)
Ni (mg/kg) urine	0.800 (p=0.333)	0.800 (p=0.333)	0.800 (p=0.333)	1.000 (p=0.083)	1.000 (p=0.083)	0.600 (p=0.417)	(p<0.001)

0.2.7 Metals (pre-dialysis blood) ~ Metals (post-dialysis blood)

VS. (Spearman R)	Al (mg/kg) post-dialysis blood	Cu (mg/kg) post-dialysis blood	Fe (mg/kg) post-dialysis blood	Zn (mg/kg) post-dialysis blood	K (mg/kg) post-dialysis blood	Na (mg/kg) post-dialysis blood	Pb (mg/kg) post-dialysis blood	Cd (mg/kg) post-dialysis blood	Ni (mg/kg) post-dialysis blood
Al (mg/kg) pre-dialysis blood	0.119 (p=0.626)	-0.031 (p=0.901)	-0.482 (p=0.038)	0.046 (p=0.854)	-0.033 (p=0.894)	-0.533 (p=0.020)	-0.562 (p=0.046)	-0.385 (p=0.196)	-0.691 (p=0.009)
Cu (mg/kg) pre-dialysis blood	-0.375 (p=0.114)	-0.454 (p=0.051)	0.563 (p=0.013)	-0.379 (p=0.110)	-0.186 (p=0.444)	0.433 (p=0.065)	-0.350 (p=0.241)	-0.033 (p=0.921)	-0.264 (p=0.383)
Fe (mg/kg) pre-dialysis blood	-0.418 (p=0.077)	-0.424 (p=0.071)	0.509 (p=0.028)	-0.284 (p=0.237)	-0.260 (p=0.282)	0.402 (p=0.089)	-0.006 (p=0.986)	-0.159 (p=0.604)	0.201 (p=0.511)
Zn (mg/kg) pre-dialysis blood	-0.442 (p=0.060)	-0.727 (p<0.001)	0.188 (p=0.440)	-0.211 (p=0.385)	-0.172 (p=0.480)	0.247 (p=0.306)	-0.496 (p=0.085)	-0.500 (p=0.085)	-0.509 (p=0.076)
K (mg/kg) pre-dialysis blood	-0.005 (p=0.986)	-0.261 (p=0.281)	-0.096 (p=0.694)	0.149 (p=0.541)	0.089 (p=0.716)	-0.449 (p=0.055)	-0.455 (p=0.119)	-0.247 (p=0.415)	-0.173 (p=0.571)
Na (mg/kg) pre-dialysis blood	-0.389 (p=0.100)	-0.427 (p=0.068)	0.602 (p=0.008)	-0.189 (p=0.436)	-0.260 (p=0.282)	0.607 (p=0.007)	0.113 (p=0.713)	0.099 (p=0.751)	0.358 (p=0.230)
Pb (mg/kg) pre-dialysis blood	-0.269 (p=0.373)	-0.572 (p=0.041)	-0.533 (p=0.064)	-0.341 (p=0.255)	-0.148 (p=0.630)	-0.060 (p=0.849)	-0.311 (p=0.301)	-0.159 (p=0.604)	-0.718 (p=0.006)
Cd (mg/kg) pre-dialysis blood	-0.058 (p=0.851)	-0.371 (p=0.213)	-0.638 (p=0.019)	-0.171 (p=0.577)	0.165 (p=0.590)	-0.187 (p=0.541)	-0.390 (p=0.187)	0.110 (p=0.720)	-0.581 (p=0.037)
Ni (mg/kg) pre-dialysis blood	-0.126 (p=0.683)	-0.534 (p=0.060)	-0.165 (p=0.591)	-0.407 (p=0.170)	-0.176 (p=0.566)	-0.484 (p=0.097)	-0.705 (p=0.007)	-0.269 (p=0.373)	-0.597 (p=0.031)

0.2.8 Metals (pre-dialysis blood) ~ Metals (urine)

VS. (Spearman R)	Al (mg/kg) urine	Cu (mg/kg) urine	Fe (mg/kg) urine	Zn (mg/kg) urine	K (mg/kg) urine	Na (mg/kg) urine	Ni (mg/kg) urine
Al (mg/kg) pre-dialysis blood	-0.464 (p=0.302)	-0.393 (p=0.396)	-0.607 (p=0.167)	-0.393 (p=0.396)	-0.393 (p=0.396)	-0.250 (p=0.595)	-0.600 (p=0.417)
Cu (mg/kg) pre-dialysis blood	0.464 (p=0.302)	0.286 (p=0.556)	0.607 (p=0.167)	0.571 (p=0.200)	0.071 (p=0.906)	-0.393 (p=0.396)	0.400 (p=0.750)
Fe (mg/kg) pre-dialysis blood	0.179 (p=0.713)	0.143 (p=0.783)	0.464 (p=0.302)	0.179 (p=0.713)	0.286 (p=0.556)	0.000 (p>0.999)	-0.400 (p=0.750)
Zn (mg/kg) pre-dialysis blood	-0.286 (p=0.556)	-0.464 (p=0.302)	-0.071 (p=0.906)	-0.286 (p=0.556)	-0.429 (p=0.354)	-0.536 (p=0.236)	-0.800 (p=0.333)
K (mg/kg) pre-dialysis blood	-0.214 (p=0.662)	-0.393 (p=0.396)	0.000 (p>0.999)	-0.143 (p=0.783)	-0.214 (p=0.662)	-0.393 (p=0.396)	-0.400 (p=0.750)
Na (mg/kg) pre-dialysis blood	0.643 (p=0.139)	0.357 (p=0.444)	0.750 (p=0.066)	0.357 (p=0.444)	0.500 (p=0.267)	0.357 (p=0.444)	0.000 (p>0.999)
Pb (mg/kg) pre-dialysis blood	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA
Cd (mg/kg) pre-dialysis blood	-1.000 (p>0.999)	-1.000 (p>0.999)	-1.000 (p>0.999)	1.000 (p>0.999)	1.000 (p>0.999)	-1.000 (p>0.999)	1.000 (p>0.999)
Ni (mg/kg) pre-dialysis blood	-1.000 (p=0.333)	-1.000 (p=0.333)	-1.000 (p=0.333)	-0.500 (p>0.999)	-0.500 (p>0.999)	-1.000 (p=0.333)	-0.500 (p>0.999)

0.2.9 Metals (post-dialysis blood) ~ Metals (urine)

VS. (Spearman R)	Al (mg/kg) urine	Cu (mg/kg) urine	Fe (mg/kg) urine	Zn (mg/kg) urine	K (mg/kg) urine	Na (mg/kg) urine	Ni (mg/kg) urine
Al (mg/kg) post-dialysis blood	0.800 (p=0.333)	0.000 (p>0.999)	0.600 (p=0.417)	0.600 (p=0.417)	-0.400 (p=0.750)	-0.400 (p=0.750)	NA (NA
Cu (mg/kg) post-dialysis blood	-1.000 (p=0.083)	-0.400 (p=0.750)	-0.800 (p=0.333)	-0.800 (p=0.333)	0.000 (p>0.999)	0.000 (p>0.999)	NA (NA
Fe (mg/kg) post-dialysis blood	-0.400 (p=0.750)	0.400 (p=0.750)	0.200 (p=0.917)	0.200 (p=0.917)	-0.800 (p=0.333)	-0.800 (p=0.333)	NA (NA
Zn (mg/kg) post-dialysis blood	-0.400 (p=0.750)	0.400 (p=0.750)	0.200 (p=0.917)	0.200 (p=0.917)	-0.800 (p=0.333)	-0.800 (p=0.333)	NA (NA
K (mg/kg) post-dialysis blood	0.600 (p=0.417)	0.400 (p=0.750)	0.800 (p=0.333)	0.800 (p=0.333)	-0.800 (p=0.333)	-0.800 (p=0.333)	NA (NA
Na (mg/kg) post-dialysis blood	0.000 (p>0.999)	0.200 (p=0.917)	0.400 (p=0.750)	0.400 (p=0.750)	-1.000 (p=0.083)	-1.000 (p=0.083)	NA (NA
Pb (mg/kg) post-dialysis blood	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA
Cd (mg/kg) post-dialysis blood	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA
Ni (mg/kg) post-dialysis blood	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA

0.2.10 Laboratory

VS. (Spearman R)	RBC (x10*6/μl)	Hemoglobin (g/dl)	Eosinophiles (%)	WBC (x10*3/μl)	Platelets (x10*3/μl)	Blood iron (mg/dl)	Ferritin (ng/ml)	Transferrin (mg/dl)	Total Ca (mg/dl)	Ionized Ca (mmoli/l)	Mg (mg/dl)	P ( mg/dl)	PTH (pg/ml)	ALP (IU/L)	Vitamine D (ng/ml)	Urea (mg/dl)	Creatinine (mg/dl)
RBC (x10*6/μl)	(p<0.001)	0.636 (p<0.001)	-0.162 (p=0.298)	-0.036 (p=0.821)	0.292 (p=0.057)	-0.176 (p=0.297)	-0.449 (p=0.021)	0.292 (p=0.084)	0.192 (p=0.218)	0.243 (p=0.117)	-0.060 (p=0.702)	0.185 (p=0.235)	0.055 (p=0.738)	-0.248 (p=0.114)	0.617 (p=0.086)	-0.302 (p=0.049)	-0.146 (p=0.349)
Hemoglobin (g/dl)	0.636 (p<0.001)	(p<0.001)	0.014 (p=0.930)	-0.124 (p=0.428)	-0.025 (p=0.872)	-0.022 (p=0.896)	-0.085 (p=0.679)	0.065 (p=0.705)	0.258 (p=0.094)	0.392 (p=0.009)	-0.037 (p=0.813)	0.092 (p=0.559)	0.184 (p=0.256)	-0.070 (p=0.661)	0.500 (p=0.178)	-0.175 (p=0.261)	-0.010 (p=0.950)
Eosinophiles (%)	-0.162 (p=0.298)	0.014 (p=0.930)	(p<0.001)	-0.115 (p=0.463)	-0.124 (p=0.429)	0.123 (p=0.470)	0.182 (p=0.373)	-0.132 (p=0.442)	-0.238 (p=0.124)	-0.283 (p=0.066)	0.247 (p=0.111)	0.127 (p=0.418)	0.388 (p=0.013)	0.562 (p<0.001)	0.533 (p=0.148)	-0.001 (p=0.993)	0.215 (p=0.165)
WBC (x10*3/μl)	-0.036 (p=0.821)	-0.124 (p=0.428)	-0.115 (p=0.463)	(p<0.001)	0.416 (p=0.006)	-0.136 (p=0.422)	0.059 (p=0.774)	0.318 (p=0.058)	-0.071 (p=0.652)	-0.074 (p=0.639)	-0.293 (p=0.057)	-0.132 (p=0.400)	-0.045 (p=0.783)	0.004 (p=0.979)	-0.300 (p=0.437)	0.160 (p=0.306)	-0.200 (p=0.199)
Platelets (x10*3/μl)	0.292 (p=0.057)	-0.025 (p=0.872)	-0.124 (p=0.429)	0.416 (p=0.006)	(p<0.001)	-0.236 (p=0.159)	-0.552 (p=0.004)	0.607 (p<0.001)	0.153 (p=0.329)	0.078 (p=0.621)	-0.407 (p=0.007)	0.101 (p=0.518)	-0.101 (p=0.536)	-0.384 (p=0.012)	0.483 (p=0.194)	-0.105 (p=0.503)	-0.077 (p=0.621)
Blood iron (mg/dl)	-0.176 (p=0.297)	-0.022 (p=0.896)	0.123 (p=0.470)	-0.136 (p=0.422)	-0.236 (p=0.159)	(p<0.001)	0.358 (p=0.080)	-0.414 (p=0.013)	0.224 (p=0.182)	0.187 (p=0.267)	0.231 (p=0.168)	-0.029 (p=0.866)	-0.062 (p=0.718)	0.053 (p=0.756)	0.300 (p=0.437)	0.151 (p=0.371)	-0.239 (p=0.155)
Ferritin (ng/ml)	-0.449 (p=0.021)	-0.085 (p=0.679)	0.182 (p=0.373)	0.059 (p=0.774)	-0.552 (p=0.004)	0.358 (p=0.080)	(p<0.001)	-0.615 (p=0.001)	-0.577 (p=0.002)	-0.574 (p=0.002)	0.262 (p=0.196)	0.006 (p=0.978)	0.279 (p=0.168)	0.452 (p=0.022)	-0.143 (p=0.752)	0.264 (p=0.192)	0.378 (p=0.057)
Transferrin (mg/dl)	0.292 (p=0.084)	0.065 (p=0.705)	-0.132 (p=0.442)	0.318 (p=0.058)	0.607 (p<0.001)	-0.414 (p=0.013)	-0.615 (p=0.001)	(p<0.001)	0.276 (p=0.103)	0.425 (p=0.010)	-0.733 (p<0.001)	0.453 (p=0.006)	-0.083 (p=0.638)	-0.219 (p=0.198)	-0.476 (p=0.243)	0.148 (p=0.390)	0.039 (p=0.820)
Total Ca (mg/dl)	0.192 (p=0.218)	0.258 (p=0.094)	-0.238 (p=0.124)	-0.071 (p=0.652)	0.153 (p=0.329)	0.224 (p=0.182)	-0.577 (p=0.002)	0.276 (p=0.103)	(p<0.001)	0.821 (p<0.001)	-0.130 (p=0.405)	0.073 (p=0.643)	-0.319 (p=0.045)	-0.286 (p=0.066)	0.350 (p=0.359)	0.190 (p=0.222)	-0.005 (p=0.977)
Ionized Ca (mmoli/l)	0.243 (p=0.117)	0.392 (p=0.009)	-0.283 (p=0.066)	-0.074 (p=0.639)	0.078 (p=0.621)	0.187 (p=0.267)	-0.574 (p=0.002)	0.425 (p=0.010)	0.821 (p<0.001)	(p<0.001)	-0.244 (p=0.114)	0.147 (p=0.348)	-0.265 (p=0.098)	-0.192 (p=0.222)	0.109 (p=0.781)	0.264 (p=0.087)	0.091 (p=0.561)
Mg (mg/dl)	-0.060 (p=0.702)	-0.037 (p=0.813)	0.247 (p=0.111)	-0.293 (p=0.057)	-0.407 (p=0.007)	0.231 (p=0.168)	0.262 (p=0.196)	-0.733 (p<0.001)	-0.130 (p=0.405)	-0.244 (p=0.114)	(p<0.001)	-0.280 (p=0.069)	-0.016 (p=0.923)	0.289 (p=0.064)	0.561 (p=0.116)	-0.228 (p=0.141)	-0.179 (p=0.252)
P ( mg/dl)	0.185 (p=0.235)	0.092 (p=0.559)	0.127 (p=0.418)	-0.132 (p=0.400)	0.101 (p=0.518)	-0.029 (p=0.866)	0.006 (p=0.978)	0.453 (p=0.006)	0.073 (p=0.643)	0.147 (p=0.348)	-0.280 (p=0.069)	(p<0.001)	0.072 (p=0.658)	-0.085 (p=0.592)	-0.217 (p=0.581)	0.462 (p=0.002)	0.245 (p=0.114)
PTH (pg/ml)	0.055 (p=0.738)	0.184 (p=0.256)	0.388 (p=0.013)	-0.045 (p=0.783)	-0.101 (p=0.536)	-0.062 (p=0.718)	0.279 (p=0.168)	-0.083 (p=0.638)	-0.319 (p=0.045)	-0.265 (p=0.098)	-0.016 (p=0.923)	0.072 (p=0.658)	(p<0.001)	0.511 (p<0.001)	-0.250 (p=0.521)	0.105 (p=0.521)	-0.048 (p=0.767)
ALP (IU/L)	-0.248 (p=0.114)	-0.070 (p=0.661)	0.562 (p<0.001)	0.004 (p=0.979)	-0.384 (p=0.012)	0.053 (p=0.756)	0.452 (p=0.022)	-0.219 (p=0.198)	-0.286 (p=0.066)	-0.192 (p=0.222)	0.289 (p=0.064)	-0.085 (p=0.592)	0.511 (p<0.001)	(p<0.001)	-0.283 (p=0.463)	0.270 (p=0.084)	0.039 (p=0.808)
Vitamine D (ng/ml)	0.617 (p=0.086)	0.500 (p=0.178)	0.533 (p=0.148)	-0.300 (p=0.437)	0.483 (p=0.194)	0.300 (p=0.437)	-0.143 (p=0.752)	-0.476 (p=0.243)	0.350 (p=0.359)	0.109 (p=0.781)	0.561 (p=0.116)	-0.217 (p=0.581)	-0.250 (p=0.521)	-0.283 (p=0.463)	(p<0.001)	-0.600 (p=0.097)	-0.017 (p=0.982)
Urea (mg/dl)	-0.302 (p=0.049)	-0.175 (p=0.261)	-0.001 (p=0.993)	0.160 (p=0.306)	-0.105 (p=0.503)	0.151 (p=0.371)	0.264 (p=0.192)	0.148 (p=0.390)	0.190 (p=0.222)	0.264 (p=0.087)	-0.228 (p=0.141)	0.462 (p=0.002)	0.105 (p=0.521)	0.270 (p=0.084)	-0.600 (p=0.097)	(p<0.001)	0.099 (p=0.528)
Creatinine (mg/dl)	-0.146 (p=0.349)	-0.010 (p=0.950)	0.215 (p=0.165)	-0.200 (p=0.199)	-0.077 (p=0.621)	-0.239 (p=0.155)	0.378 (p=0.057)	0.039 (p=0.820)	-0.005 (p=0.977)	0.091 (p=0.561)	-0.179 (p=0.252)	0.245 (p=0.114)	-0.048 (p=0.767)	0.039 (p=0.808)	-0.017 (p=0.982)	0.099 (p=0.528)	(p<0.001)

0.2.11 Laboratory ~ Metals (pre-dialysis blood)

VS. (Spearman R)	Al (mg/kg) pre-dialysis blood	Cu (mg/kg) pre-dialysis blood	Fe (mg/kg) pre-dialysis blood	Zn (mg/kg) pre-dialysis blood	K (mg/kg) pre-dialysis blood	Na (mg/kg) pre-dialysis blood	Pb (mg/kg) pre-dialysis blood	Cd (mg/kg) pre-dialysis blood	Ni (mg/kg) pre-dialysis blood
RBC (x10*6/μl)	0.433 (p=0.006)	-0.075 (p=0.652)	-0.080 (p=0.627)	0.018 (p=0.914)	0.013 (p=0.938)	0.006 (p=0.973)	0.141 (p=0.449)	-0.009 (p=0.963)	-0.002 (p=0.993)
Hemoglobin (g/dl)	0.305 (p=0.059)	-0.030 (p=0.857)	0.162 (p=0.326)	0.090 (p=0.585)	0.182 (p=0.268)	-0.085 (p=0.616)	0.196 (p=0.291)	0.155 (p=0.396)	0.324 (p=0.065)
Eosinophiles (%)	0.169 (p=0.303)	0.190 (p=0.246)	0.155 (p=0.347)	0.133 (p=0.419)	0.323 (p=0.045)	0.132 (p=0.437)	-0.030 (p=0.872)	-0.126 (p=0.493)	0.040 (p=0.823)
WBC (x10*3/μl)	0.077 (p=0.643)	-0.141 (p=0.393)	-0.179 (p=0.275)	0.218 (p=0.183)	-0.035 (p=0.834)	-0.087 (p=0.608)	-0.196 (p=0.290)	0.051 (p=0.781)	0.029 (p=0.875)
Platelets (x10*3/μl)	0.256 (p=0.115)	-0.343 (p=0.033)	-0.154 (p=0.349)	0.093 (p=0.572)	-0.160 (p=0.330)	-0.111 (p=0.512)	-0.288 (p=0.116)	-0.298 (p=0.098)	-0.266 (p=0.135)
Blood iron (mg/dl)	-0.467 (p=0.004)	0.390 (p=0.019)	0.381 (p=0.023)	-0.046 (p=0.790)	0.066 (p=0.703)	0.241 (p=0.169)	0.133 (p=0.501)	0.030 (p=0.876)	0.030 (p=0.876)
Ferritin (ng/ml)	-0.352 (p=0.085)	0.130 (p=0.534)	0.133 (p=0.524)	-0.062 (p=0.770)	0.173 (p=0.406)	-0.191 (p=0.359)	0.154 (p=0.541)	0.395 (p=0.104)	0.442 (p=0.060)
Transferrin (mg/dl)	0.424 (p=0.011)	-0.061 (p=0.729)	-0.120 (p=0.491)	0.340 (p=0.046)	-0.147 (p=0.399)	0.226 (p=0.206)	-0.402 (p=0.038)	-0.487 (p=0.009)	-0.514 (p=0.004)
Total Ca (mg/dl)	-0.083 (p=0.615)	0.043 (p=0.794)	0.194 (p=0.237)	0.271 (p=0.095)	0.076 (p=0.644)	0.297 (p=0.075)	-0.219 (p=0.237)	-0.360 (p=0.043)	-0.258 (p=0.148)
Ionized Ca (mmoli/l)	0.056 (p=0.733)	0.119 (p=0.472)	0.110 (p=0.504)	0.303 (p=0.061)	0.077 (p=0.639)	0.289 (p=0.082)	-0.177 (p=0.340)	-0.321 (p=0.073)	-0.241 (p=0.177)
Mg (mg/dl)	-0.212 (p=0.195)	0.027 (p=0.870)	0.121 (p=0.462)	-0.319 (p=0.048)	0.091 (p=0.581)	-0.095 (p=0.575)	0.491 (p=0.005)	0.473 (p=0.006)	0.506 (p=0.003)
P ( mg/dl)	0.128 (p=0.438)	0.285 (p=0.079)	0.247 (p=0.130)	0.267 (p=0.100)	0.300 (p=0.063)	0.340 (p=0.040)	-0.100 (p=0.594)	-0.322 (p=0.073)	-0.327 (p=0.064)
PTH (pg/ml)	0.148 (p=0.375)	0.050 (p=0.767)	0.086 (p=0.607)	-0.305 (p=0.063)	0.230 (p=0.164)	0.097 (p=0.567)	-0.046 (p=0.810)	0.006 (p=0.974)	0.014 (p=0.939)
ALP (IU/L)	0.088 (p=0.594)	0.171 (p=0.297)	0.074 (p=0.652)	-0.075 (p=0.650)	0.260 (p=0.109)	0.120 (p=0.477)	0.039 (p=0.837)	0.063 (p=0.732)	0.107 (p=0.552)
Vitamine D (ng/ml)	0.619 (p=0.115)	0.000 (p>0.999)	0.095 (p=0.840)	0.357 (p=0.389)	0.167 (p=0.703)	-0.119 (p=0.793)	-0.500 (p=0.267)	0.054 (p=0.908)	0.357 (p=0.444)
Urea (mg/dl)	-0.035 (p=0.835)	0.237 (p=0.146)	0.093 (p=0.573)	0.208 (p=0.203)	0.293 (p=0.070)	0.198 (p=0.239)	-0.144 (p=0.439)	-0.180 (p=0.325)	-0.328 (p=0.062)
Creatinine (mg/dl)	0.136 (p=0.410)	0.037 (p=0.823)	0.087 (p=0.600)	0.360 (p=0.024)	0.191 (p=0.244)	0.023 (p=0.894)	-0.297 (p=0.105)	-0.349 (p=0.050)	-0.186 (p=0.301)

0.2.12 Laboratory ~ Metals (post-dialysis blood)

VS. (Spearman R)	Al (mg/kg) post-dialysis blood	Cu (mg/kg) post-dialysis blood	Fe (mg/kg) post-dialysis blood	Zn (mg/kg) post-dialysis blood	K (mg/kg) post-dialysis blood	Na (mg/kg) post-dialysis blood	Pb (mg/kg) post-dialysis blood	Cd (mg/kg) post-dialysis blood	Ni (mg/kg) post-dialysis blood
RBC (x10*6/μl)	0.011 (p=0.966)	0.218 (p=0.369)	-0.331 (p=0.166)	0.011 (p=0.963)	-0.307 (p=0.202)	-0.267 (p=0.269)	-0.201 (p=0.509)	-0.245 (p=0.420)	-0.256 (p=0.398)
Hemoglobin (g/dl)	0.032 (p=0.898)	0.031 (p=0.899)	-0.266 (p=0.270)	-0.128 (p=0.600)	-0.449 (p=0.054)	-0.366 (p=0.123)	-0.377 (p=0.205)	-0.492 (p=0.087)	-0.417 (p=0.156)
Eosinophiles (%)	-0.074 (p=0.764)	-0.253 (p=0.296)	0.121 (p=0.621)	-0.130 (p=0.596)	-0.114 (p=0.641)	-0.214 (p=0.378)	-0.382 (p=0.198)	0.074 (p=0.809)	0.051 (p=0.869)
WBC (x10*3/μl)	-0.007 (p=0.980)	-0.043 (p=0.861)	-0.051 (p=0.837)	-0.032 (p=0.900)	0.119 (p=0.626)	-0.091 (p=0.710)	-0.146 (p=0.634)	0.341 (p=0.255)	-0.168 (p=0.584)
Platelets (x10*3/μl)	0.051 (p=0.837)	0.443 (p=0.057)	-0.040 (p=0.871)	0.423 (p=0.073)	0.123 (p=0.616)	0.096 (p=0.694)	0.298 (p=0.324)	0.137 (p=0.656)	0.349 (p=0.242)
Blood iron (mg/dl)	-0.339 (p=0.156)	-0.248 (p=0.305)	0.272 (p=0.259)	-0.293 (p=0.223)	-0.044 (p=0.860)	0.251 (p=0.299)	0.025 (p=0.936)	0.203 (p=0.505)	0.102 (p=0.741)
Ferritin (ng/ml)	0.146 (p=0.563)	-0.159 (p=0.529)	-0.273 (p=0.271)	-0.141 (p=0.575)	0.298 (p=0.229)	-0.073 (p=0.773)	-0.428 (p=0.165)	0.224 (p=0.485)	-0.546 (p=0.066)
Transferrin (mg/dl)	0.040 (p=0.876)	0.248 (p=0.321)	0.240 (p=0.335)	0.298 (p=0.229)	0.391 (p=0.109)	0.416 (p=0.087)	0.579 (p=0.049)	0.531 (p=0.079)	0.666 (p=0.018)
Total Ca (mg/dl)	-0.219 (p=0.365)	-0.233 (p=0.338)	0.142 (p=0.560)	0.219 (p=0.365)	-0.151 (p=0.536)	0.030 (p=0.905)	-0.143 (p=0.641)	-0.484 (p=0.097)	0.044 (p=0.886)
Ionized Ca (mmoli/l)	-0.227 (p=0.349)	-0.228 (p=0.347)	0.149 (p=0.542)	0.031 (p=0.901)	-0.115 (p=0.639)	0.138 (p=0.573)	-0.070 (p=0.819)	-0.473 (p=0.102)	-0.263 (p=0.385)
Mg (mg/dl)	-0.303 (p=0.207)	-0.195 (p=0.423)	0.035 (p=0.887)	0.180 (p=0.461)	-0.263 (p=0.276)	0.031 (p=0.901)	-0.004 (p=0.989)	-0.259 (p=0.394)	-0.018 (p=0.954)
P ( mg/dl)	-0.440 (p=0.061)	-0.252 (p=0.298)	0.181 (p=0.457)	-0.195 (p=0.423)	0.088 (p=0.721)	0.365 (p=0.125)	0.196 (p=0.522)	0.275 (p=0.363)	-0.088 (p=0.775)
PTH (pg/ml)	0.126 (p=0.605)	0.226 (p=0.353)	0.067 (p=0.787)	-0.004 (p=0.991)	-0.009 (p=0.974)	0.016 (p=0.951)	0.201 (p=0.510)	0.588 (p=0.038)	0.261 (p=0.388)
ALP (IU/L)	0.198 (p=0.414)	-0.048 (p=0.844)	0.023 (p=0.928)	-0.126 (p=0.605)	0.288 (p=0.231)	0.028 (p=0.911)	-0.080 (p=0.795)	0.335 (p=0.263)	-0.055 (p=0.858)
Vitamine D (ng/ml)	-0.179 (p=0.713)	-0.342 (p=0.452)	-0.143 (p=0.783)	-0.321 (p=0.498)	-0.643 (p=0.139)	-0.643 (p=0.139)	-0.771 (p=0.103)	-0.600 (p=0.242)	-0.429 (p=0.419)
Urea (mg/dl)	-0.025 (p=0.922)	0.027 (p=0.912)	-0.181 (p=0.457)	0.133 (p=0.585)	0.356 (p=0.135)	0.070 (p=0.776)	0.281 (p=0.352)	0.522 (p=0.071)	-0.061 (p=0.844)
Creatinine (mg/dl)	-0.118 (p=0.629)	-0.257 (p=0.288)	-0.241 (p=0.320)	-0.318 (p=0.185)	-0.290 (p=0.228)	-0.173 (p=0.479)	-0.543 (p=0.055)	-0.374 (p=0.208)	-0.780 (p=0.002)

0.2.13 Laboratory ~ Metals (urine)

VS. (Spearman R)	Al (mg/kg) urine	Cu (mg/kg) urine	Fe (mg/kg) urine	Zn (mg/kg) urine	K (mg/kg) urine	Na (mg/kg) urine	Ni (mg/kg) urine
RBC (x10*6/μl)	-0.357 (p=0.444)	-0.179 (p=0.713)	-0.607 (p=0.167)	-0.143 (p=0.783)	-0.179 (p=0.713)	-0.036 (p=0.963)	0.800 (p=0.333)
Hemoglobin (g/dl)	-0.536 (p=0.236)	-0.643 (p=0.139)	-0.679 (p=0.110)	-0.571 (p=0.200)	0.143 (p=0.783)	0.393 (p=0.396)	-0.400 (p=0.750)
Eosinophiles (%)	0.036 (p=0.963)	-0.393 (p=0.396)	-0.214 (p=0.662)	-0.393 (p=0.396)	0.357 (p=0.444)	0.679 (p=0.110)	-1.000 (p=0.083)
WBC (x10*3/μl)	0.036 (p=0.963)	0.393 (p=0.396)	0.286 (p=0.556)	0.214 (p=0.662)	-0.357 (p=0.444)	-0.571 (p=0.200)	-0.400 (p=0.750)
Platelets (x10*3/μl)	-0.214 (p=0.662)	-0.036 (p=0.963)	-0.321 (p=0.498)	-0.071 (p=0.906)	-0.536 (p=0.236)	-0.393 (p=0.396)	0.400 (p=0.750)
Blood iron (mg/dl)	0.321 (p=0.498)	0.143 (p=0.783)	0.536 (p=0.236)	0.357 (p=0.444)	0.214 (p=0.662)	-0.179 (p=0.713)	0.200 (p=0.917)
Ferritin (ng/ml)	0.200 (p=0.783)	-0.100 (p=0.950)	0.700 (p=0.233)	0.000 (p>0.999)	-0.200 (p=0.783)	-0.100 (p=0.950)	-1.000 (p>0.999)
Transferrin (mg/dl)	-0.179 (p=0.713)	0.107 (p=0.840)	-0.286 (p=0.556)	0.000 (p>0.999)	-0.286 (p=0.556)	-0.286 (p=0.556)	0.200 (p=0.917)
Total Ca (mg/dl)	0.000 (p>0.999)	0.214 (p=0.662)	0.143 (p=0.783)	0.393 (p=0.396)	0.000 (p>0.999)	-0.464 (p=0.302)	0.400 (p=0.750)
Ionized Ca (mmoli/l)	0.000 (p>0.999)	0.214 (p=0.662)	0.143 (p=0.783)	0.393 (p=0.396)	0.000 (p>0.999)	-0.464 (p=0.302)	0.400 (p=0.750)
Mg (mg/dl)	0.250 (p=0.595)	0.036 (p=0.963)	0.286 (p=0.556)	-0.036 (p=0.963)	0.607 (p=0.167)	0.679 (p=0.110)	-0.400 (p=0.750)
P ( mg/dl)	-0.429 (p=0.354)	-0.393 (p=0.396)	-0.321 (p=0.498)	-0.357 (p=0.444)	-0.893 (p=0.012)	-0.821 (p=0.034)	-0.800 (p=0.333)
PTH (pg/ml)	-0.500 (p=0.267)	-0.107 (p=0.840)	-0.571 (p=0.200)	-0.250 (p=0.595)	0.071 (p=0.906)	0.143 (p=0.783)	0.000 (p>0.999)
ALP (IU/L)	0.036 (p=0.963)	-0.357 (p=0.444)	-0.036 (p=0.963)	-0.286 (p=0.556)	0.286 (p=0.556)	0.393 (p=0.396)	-0.800 (p=0.333)
Vitamine D (ng/ml)	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA	NA (NA
Urea (mg/dl)	-0.179 (p=0.713)	-0.036 (p=0.963)	-0.036 (p=0.963)	0.107 (p=0.840)	-0.536 (p=0.236)	-0.821 (p=0.034)	0.000 (p>0.999)
Creatinine (mg/dl)	-0.607 (p=0.167)	-0.929 (p=0.007)	-0.679 (p=0.110)	-0.893 (p=0.012)	-0.536 (p=0.236)	-0.071 (p=0.906)	-1.000 (p=0.083)

1 References

1. R Core Team (2020). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.