Background

Description

Prevelance

Research

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

  • Determined 143 Risk Variants
  • 139 common / 4 rare

Development of a Predictive Model for Type 2 Diabetes Mellitus Using Genetic and Clinical Data

  • Identified of 499 SNPS from 87 T2D related genes
  • Classification Algorithms
    • Logistic Regression
    • K-nearest neighbor

Methods

Proposition

Approach

Results (Preliminary)

Develop a Patient Cohort

Load Genotype Data

  • Only Processed about 30 individual’s genomic data
Genomic Data for Type 2 Diabetes Patient
rsID Chromosome Position Genotype
rs4477212 1 72017 AA
rs3094315 1 742429 AG
rs3131972 1 742584 AG
rs12124819 1 766409 AA
rs11240777 1 788822 AA

Tabulate Data

  • Frequency of Various SNP mutations
.outcome AA AC AG AT
no 55397 4385 29355 2
yes 88046 16231 72008 294
no 88710 16477 71883 312
no 89002 15283 65806 441
no 89467 16773 73171 300

Random Forest

mtry ROC Sens Spec
2 0.70 0.55 0.75
15 0.68 0.55 0.75
29 0.68 0.60 0.70

K-Nearest Neighbors

k ROC Sens Spec
5 0.60 0.50 0.65
7 0.68 0.65 0.70
9 0.75 0.60 0.75

Next Steps