샘플을 불러오자
Loading required package: SNPassoc
Loading required package: haplo.stats
Loading required package: survival
Loading required package: mvtnorm
Loading required package: parallel
Registered S3 method overwritten by 'SNPassoc':
method from
summary.haplo.glm haplo.stats
group sex age smoke
Control :2042 Male :2679 Min. :49.00 Never :3892
MedDiet + Nuts:2100 Female:3645 1st Qu.:62.00 Current: 858
MedDiet + VOO :2182 Median :67.00 Former :1574
Mean :67.01
3rd Qu.:72.00
Max. :87.00
bmi waist wth htn diab
Min. :19.64 Min. : 50.0 Min. :0.3012 No :1089 No :3322
1st Qu.:27.23 1st Qu.: 93.0 1st Qu.:0.5839 Yes:5235 Yes:3002
Median :29.76 Median :100.0 Median :0.6258
Mean :29.97 Mean :100.4 Mean :0.6283
3rd Qu.:32.46 3rd Qu.:107.0 3rd Qu.:0.6687
Max. :51.94 Max. :177.0 Max. :1.0000
hyperchol famhist hormo p14 toevent
No :1746 No :4895 No :5564 Min. : 0.000 Min. :0.01643
Yes:4578 Yes:1429 Yes : 97 1st Qu.: 7.000 1st Qu.:2.85832
NA's: 663 Median : 9.000 Median :4.78850
Mean : 8.678 Mean :4.35517
3rd Qu.:10.000 3rd Qu.:5.79056
Max. :14.000 Max. :6.99795
event
No :6072
Yes: 252
데이터 핸들링
--------Summary descriptives table by 'Intervention group'---------
____________________________________________________________________________________
Control MedDiet + Nuts MedDiet + VOO p.overall
N=2042 N=2100 N=2182
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
Sex: <0.001
Male 812 (39.8%) 968 (46.1%) 899 (41.2%)
Female 1230 (60.2%) 1132 (53.9%) 1283 (58.8%)
Age 67.3 (6.28) 66.7 (6.02) 67.0 (6.21) 0.003
Smoking: 0.444
Never 1282 (62.8%) 1259 (60.0%) 1351 (61.9%)
Current 270 (13.2%) 296 (14.1%) 292 (13.4%)
Former 490 (24.0%) 545 (26.0%) 539 (24.7%)
Body mass index 30.3 (3.96) 29.7 (3.77) 29.9 (3.71) <0.001
Waist circumference 101 (10.8) 100 (10.6) 100 (10.4) 0.045
Waist-to-height ratio 0.63 (0.07) 0.62 (0.06) 0.63 (0.06) <0.001
Hypertension: 0.249
No 331 (16.2%) 362 (17.2%) 396 (18.1%)
Yes 1711 (83.8%) 1738 (82.8%) 1786 (81.9%)
Type-2 diabetes: 0.017
No 1072 (52.5%) 1150 (54.8%) 1100 (50.4%)
Yes 970 (47.5%) 950 (45.2%) 1082 (49.6%)
Dyslipidemia: 0.423
No 563 (27.6%) 561 (26.7%) 622 (28.5%)
Yes 1479 (72.4%) 1539 (73.3%) 1560 (71.5%)
Family history of premature CHD: 0.581
No 1580 (77.4%) 1640 (78.1%) 1675 (76.8%)
Yes 462 (22.6%) 460 (21.9%) 507 (23.2%)
Hormone-replacement therapy: 0.850
No 1811 (98.3%) 1835 (98.4%) 1918 (98.2%)
Yes 31 (1.68%) 30 (1.61%) 36 (1.84%)
MeDiet Adherence score 8.44 (1.94) 8.81 (1.90) 8.77 (1.97) <0.001
follow-up to main event (years) 4.09 (1.74) 4.31 (1.70) 4.64 (1.60) <0.001
AMI, stroke, or CV Death: 0.064
No 1945 (95.2%) 2030 (96.7%) 2097 (96.1%)
Yes 97 (4.75%) 70 (3.33%) 85 (3.90%)
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
그룹별로 나누어서 알아보자
--------Summary descriptives table ---------
_____________________________________________________________________________________________________________________________________________________________________________________________
ALL FEMALE MALE
___________________________________________________ ___________________________________________________ __________________________________________________
Control MedDiet + Nuts MedDiet + VOO p.overall Control MedDiet + Nuts MedDiet + VOO p.overall Control MedDiet + Nuts MedDiet + VOO p.overall
N=2042 N=2100 N=2182 N=1230 N=1132 N=1283 N=812 N=968 N=899
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
Age 67.3 (6.28) 66.7 (6.02) 67.0 (6.21) 0.003 68.0 (5.96) 67.4 (5.57) 67.7 (5.84) 0.056 66.4 (6.62) 65.8 (6.40) 66.1 (6.61) 0.215
Smoking: 0.444 0.907 0.851
Never 1282 (62.8%) 1259 (60.0%) 1351 (61.9%) 1077 (87.6%) 993 (87.7%) 1115 (86.9%) 205 (25.2%) 266 (27.5%) 236 (26.3%)
Current 270 (13.2%) 296 (14.1%) 292 (13.4%) 66 (5.37%) 54 (4.77%) 71 (5.53%) 204 (25.1%) 242 (25.0%) 221 (24.6%)
Former 490 (24.0%) 545 (26.0%) 539 (24.7%) 87 (7.07%) 85 (7.51%) 97 (7.56%) 403 (49.6%) 460 (47.5%) 442 (49.2%)
Body mass index 30.3 (3.96) 29.7 (3.77) 29.9 (3.71) <0.001 30.8 (4.20) 30.2 (4.08) 30.4 (3.91) 0.002 29.6 (3.45) 29.1 (3.28) 29.2 (3.28) 0.018
Waist circumference 101 (10.8) 100 (10.6) 100 (10.4) 0.045 99.0 (11.0) 97.8 (11.0) 98.0 (10.5) 0.016 104 (9.82) 103 (9.36) 103 (9.65) 0.289
Waist-to-height ratio 0.63 (0.07) 0.62 (0.06) 0.63 (0.06) <0.001 0.64 (0.07) 0.63 (0.07) 0.63 (0.07) 0.002 0.62 (0.06) 0.62 (0.06) 0.62 (0.06) 0.191
Hypertension: 0.249 0.780 0.130
No 331 (16.2%) 362 (17.2%) 396 (18.1%) 168 (13.7%) 147 (13.0%) 179 (14.0%) 163 (20.1%) 215 (22.2%) 217 (24.1%)
Yes 1711 (83.8%) 1738 (82.8%) 1786 (81.9%) 1062 (86.3%) 985 (87.0%) 1104 (86.0%) 649 (79.9%) 753 (77.8%) 682 (75.9%)
Type-2 diabetes: 0.017 0.007 0.468
No 1072 (52.5%) 1150 (54.8%) 1100 (50.4%) 690 (56.1%) 678 (59.9%) 687 (53.5%) 382 (47.0%) 472 (48.8%) 413 (45.9%)
Yes 970 (47.5%) 950 (45.2%) 1082 (49.6%) 540 (43.9%) 454 (40.1%) 596 (46.5%) 430 (53.0%) 496 (51.2%) 486 (54.1%)
Dyslipidemia: 0.423 0.319 0.575
No 563 (27.6%) 561 (26.7%) 622 (28.5%) 282 (22.9%) 246 (21.7%) 312 (24.3%) 281 (34.6%) 315 (32.5%) 310 (34.5%)
Yes 1479 (72.4%) 1539 (73.3%) 1560 (71.5%) 948 (77.1%) 886 (78.3%) 971 (75.7%) 531 (65.4%) 653 (67.5%) 589 (65.5%)
Family history of premature CHD: 0.581 0.596 0.841
No 1580 (77.4%) 1640 (78.1%) 1675 (76.8%) 903 (73.4%) 843 (74.5%) 932 (72.6%) 677 (83.4%) 797 (82.3%) 743 (82.6%)
Yes 462 (22.6%) 460 (21.9%) 507 (23.2%) 327 (26.6%) 289 (25.5%) 351 (27.4%) 135 (16.6%) 171 (17.7%) 156 (17.4%)
MeDiet Adherence score 8.44 (1.94) 8.81 (1.90) 8.77 (1.97) <0.001 8.36 (1.94) 8.77 (1.86) 8.68 (1.92) <0.001 8.57 (1.94) 8.86 (1.96) 8.91 (2.02) 0.001
follow-up to main event (years) 4.09 (1.74) 4.31 (1.70) 4.64 (1.60) <0.001 4.12 (1.71) 4.26 (1.67) 4.72 (1.56) <0.001 4.05 (1.78) 4.38 (1.74) 4.53 (1.64) <0.001
AMI, stroke, or CV Death: 0.064 0.576 0.029
No 1945 (95.2%) 2030 (96.7%) 2097 (96.1%) 1191 (96.8%) 1103 (97.4%) 1250 (97.4%) 754 (92.9%) 927 (95.8%) 847 (94.2%)
Yes 97 (4.75%) 70 (3.33%) 85 (3.90%) 39 (3.17%) 29 (2.56%) 33 (2.57%) 58 (7.14%) 41 (4.24%) 52 (5.78%)
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯