ANOVA results

Predictor df_num df_den Epsilon F p ges Method 1.98 196.02 0.99 11.66 .000 .01

Note. df_num indicates degrees of freedom numerator. df_den indicates degrees of freedom denominator. Epsilon indicates Greenhouse-Geisser multiplier for degrees of freedom, p-values and degrees of freedom in the table incorporate this correction. ges indicates generalized eta-squared.

Friedman rank sum test

data: LVEF and Method and id Friedman chi-squared = 23, df = 2, p-value = 0.00001

Subset	N	Mean ±SD	Med (min:max)
LVEF (%) (Shapiro-Wilk normality test: p=0.017)
(total)	300 (100.0%)	45.447 ±10.82	46.00 (17.00:70.0)
Method (Kruskal-Wallis rank sum test: p=0.189)
Classic	100 (33.3%)	46.090 ±9.99	46.00 (20.00:70.0)
Strain-2D	100 (33.3%)	43.630 ±10.92	46.00 (17.00:69.0)
Strain-3D	100 (33.3%)	46.620 ±11.38	47.50 (17.00:70.0)

Paired t-test

data: baza_de_date\(`FEVS (%)` and baza_de_date\)auto-EF t = 4, df = 99, p-value = 0.0002 alternative hypothesis: true difference in means is not equal to 0 95 percent confidence interval: 1.21 3.71 sample estimates: mean of the differences 2.46

Paired t-test

data: baza_de_date\(`FEVS (%)` and baza_de_date\)3d-EF t = -0.8, df = 99, p-value = 0.4 alternative hypothesis: true difference in means is not equal to 0 95 percent confidence interval: -1.894 0.834 sample estimates: mean of the differences -0.53

Paired t-test

data: baza_de_date\(`auto-EF` and baza_de_date\)3d-EF t = -5, df = 99, p-value = 0.00002 alternative hypothesis: true difference in means is not equal to 0 95 percent confidence interval: -4.31 -1.67 sample estimates: mean of the differences -2.99

1 Results

1.1 Classic parameters

Table 1: .

Variable	Details	Total
N=		100
TD diamieter (mm)	M (min:max)	48 (36:66)
	μ ±SD	48.74 ±6.42
TS diamieter (mm)	M (min:max)	34 (16:55)
	μ ±SD	34.63 ±6.56
Kinetics	SIV ant	15 (16.9%)
	SIV inf	7 (7.9%)
	PA	8 (9.0%)
	PL	15 (16.9%)
	PI	31 (34.8%)
	apex	13 (14.6%)
LVEF (%)	M (min:max)	46 (20:70)
	μ ±SD	46.09 ±9.99
Thrombus LV		4 (4.0%)
LA diamieter	M (min:max)	39 (27:53)
	μ ±SD	38.88 ±5.04
E	M (min:max)	0.6 (0.12:1.3)
	μ ±SD	0.657 ±0.188
E/A (grade)	1	75 (75.8%)
	2	16 (16.2%)
	3	8 (8.1%)
e's	M (min:max)	6.5 (2:13)
	μ ±SD	6.21 ±2.09
e'l	M (min:max)	7.5 (3:15)
	μ ±SD	7.58 ±2.58
e'med	M (min:max)	7.5 (2.5:14)
	μ ±SD	6.89 ±2.24
E/e'	M (min:max)	9.23 (1.33:36)
	μ ±SD	10.91 ±5.79
v max IT	M (min:max)	2.2 (1.2:8)
	μ ±SD	2.44 ±0.878
vol AS	M (min:max)	55 (28:135)
	μ ±SD	56.65 ±14.5
vol ASi	M (min:max)	29.13 (16.88:56.71)
	μ ±SD	29.38 ±7.06
PSAP	M (min:max)	24.36 (10.76:261)
	μ ±SD	31.77 ±26.9
TaccP	M (min:max)	109.5 (59:156)
	μ ±SD	111.62 ±22.9
PAPm	M (min:max)	19 (12:89)
	μ ±SD	20.89 ±9.35
VD (mm)	M (min:max)	34 (26:47)
	μ ±SD	35.25 ±4.34
TAPSE (mm)	M (min:max)	20 (10:27)
	μ ±SD	19.84 ±2.55
IMi	no	2 (2.0%)
	gr1	69 (69.0%)
	gr2	29 (29.0%)
	gr3	0
SMi	no	98 (98.0%)
	gr1	0
	gr2	2 (2.0%)
	gr3	0
IAo	no	79 (79.0%)
	gr1	10 (10.0%)
	gr2	11 (11.0%)
	gr3	0
Sao	no	93 (93.0%)
	gr1	3 (3.0%)
	gr2	4 (4.0%)
	gr3	0
ITi	no	0
	gr1	79 (79.0%)
	gr2	21 (21.0%)
	gr3	0
IP	no	0
	gr1	92 (92.0%)
	gr2	8 (8.0%)
	gr3	0
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

1.1.1 Correlograms

VS. (Spearman R)	TD diamieter (mm)	TS diamieter (mm)	LVEF (%)	LA diamieter	E	e's	e'l	e'med	E/e'	v max IT	vol AS	vol ASi	PSAP	TaccP	PAPm	VD (mm)	TAPSE (mm)
TD diamieter (mm)	(p<0.001)	0.753 (p<0.001)	-0.260 (p=0.009)	0.222 (p=0.027)	0.102 (p=0.314)	-0.113 (p=0.264)	-0.121 (p=0.229)	-0.122 (p=0.227)	0.194 (p=0.053)	0.123 (p=0.222)	0.368 (p<0.001)	0.331 (p<0.001)	0.123 (p=0.222)	-0.179 (p=0.075)	0.144 (p=0.154)	0.298 (p=0.003)	-0.201 (p=0.045)
TS diamieter (mm)	0.753 (p<0.001)	(p<0.001)	-0.427 (p<0.001)	0.234 (p=0.019)	0.010 (p=0.921)	-0.265 (p=0.008)	-0.256 (p=0.010)	-0.276 (p=0.005)	0.245 (p=0.014)	0.079 (p=0.436)	0.358 (p<0.001)	0.262 (p=0.008)	0.079 (p=0.436)	-0.192 (p=0.055)	0.083 (p=0.414)	0.253 (p=0.011)	-0.180 (p=0.072)
LVEF (%)	-0.260 (p=0.009)	-0.427 (p<0.001)	(p<0.001)	-0.228 (p=0.023)	-0.122 (p=0.228)	0.433 (p<0.001)	0.455 (p<0.001)	0.467 (p<0.001)	-0.462 (p<0.001)	-0.280 (p=0.005)	-0.271 (p=0.006)	-0.277 (p=0.005)	-0.280 (p=0.005)	0.360 (p<0.001)	-0.241 (p=0.016)	-0.092 (p=0.361)	0.133 (p=0.187)
LA diamieter	0.222 (p=0.027)	0.234 (p=0.019)	-0.228 (p=0.023)	(p<0.001)	0.244 (p=0.015)	-0.232 (p=0.020)	-0.216 (p=0.031)	-0.223 (p=0.025)	0.306 (p=0.002)	0.439 (p<0.001)	0.484 (p<0.001)	0.453 (p<0.001)	0.439 (p<0.001)	-0.485 (p<0.001)	0.432 (p<0.001)	0.303 (p=0.002)	-0.252 (p=0.011)
E	0.102 (p=0.314)	0.010 (p=0.921)	-0.122 (p=0.228)	0.244 (p=0.015)	(p<0.001)	-0.028 (p=0.784)	-0.075 (p=0.461)	-0.056 (p=0.582)	0.578 (p<0.001)	0.257 (p=0.010)	0.154 (p=0.125)	0.170 (p=0.091)	0.257 (p=0.010)	-0.188 (p=0.061)	0.275 (p=0.006)	0.074 (p=0.467)	-0.010 (p=0.920)
e's	-0.113 (p=0.264)	-0.265 (p=0.008)	0.433 (p<0.001)	-0.232 (p=0.020)	-0.028 (p=0.784)	(p<0.001)	0.845 (p<0.001)	0.940 (p<0.001)	-0.752 (p<0.001)	-0.169 (p=0.092)	-0.191 (p=0.057)	-0.238 (p=0.017)	-0.169 (p=0.092)	0.320 (p=0.001)	-0.306 (p=0.002)	0.005 (p=0.960)	0.135 (p=0.181)
e'l	-0.121 (p=0.229)	-0.256 (p=0.010)	0.455 (p<0.001)	-0.216 (p=0.031)	-0.075 (p=0.461)	0.845 (p<0.001)	(p<0.001)	0.972 (p<0.001)	-0.801 (p<0.001)	-0.176 (p=0.080)	-0.221 (p=0.027)	-0.275 (p=0.006)	-0.176 (p=0.080)	0.292 (p=0.003)	-0.310 (p=0.002)	-0.071 (p=0.484)	0.118 (p=0.241)
e'med	-0.122 (p=0.227)	-0.276 (p=0.005)	0.467 (p<0.001)	-0.223 (p=0.025)	-0.056 (p=0.582)	0.940 (p<0.001)	0.972 (p<0.001)	(p<0.001)	-0.809 (p<0.001)	-0.177 (p=0.078)	-0.206 (p=0.040)	-0.253 (p=0.011)	-0.177 (p=0.078)	0.310 (p=0.002)	-0.315 (p=0.001)	-0.050 (p=0.618)	0.133 (p=0.188)
E/e'	0.194 (p=0.053)	0.245 (p=0.014)	-0.462 (p<0.001)	0.306 (p=0.002)	0.578 (p<0.001)	-0.752 (p<0.001)	-0.801 (p<0.001)	-0.809 (p<0.001)	(p<0.001)	0.311 (p=0.002)	0.281 (p=0.005)	0.314 (p=0.001)	0.311 (p=0.002)	-0.372 (p<0.001)	0.421 (p<0.001)	0.061 (p=0.549)	-0.124 (p=0.219)
v max IT	0.123 (p=0.222)	0.079 (p=0.436)	-0.280 (p=0.005)	0.439 (p<0.001)	0.257 (p=0.010)	-0.169 (p=0.092)	-0.176 (p=0.080)	-0.177 (p=0.078)	0.311 (p=0.002)	(p<0.001)	0.434 (p<0.001)	0.477 (p<0.001)	1.000 (p<0.001)	-0.685 (p<0.001)	0.599 (p<0.001)	0.104 (p=0.305)	-0.161 (p=0.110)
vol AS	0.368 (p<0.001)	0.358 (p<0.001)	-0.271 (p=0.006)	0.484 (p<0.001)	0.154 (p=0.125)	-0.191 (p=0.057)	-0.221 (p=0.027)	-0.206 (p=0.040)	0.281 (p=0.005)	0.434 (p<0.001)	(p<0.001)	0.888 (p<0.001)	0.434 (p<0.001)	-0.467 (p<0.001)	0.491 (p<0.001)	0.320 (p=0.001)	-0.247 (p=0.013)
vol ASi	0.331 (p<0.001)	0.262 (p=0.008)	-0.277 (p=0.005)	0.453 (p<0.001)	0.170 (p=0.091)	-0.238 (p=0.017)	-0.275 (p=0.006)	-0.253 (p=0.011)	0.314 (p=0.001)	0.477 (p<0.001)	0.888 (p<0.001)	(p<0.001)	0.477 (p<0.001)	-0.488 (p<0.001)	0.501 (p<0.001)	0.241 (p=0.016)	-0.279 (p=0.005)
PSAP	0.123 (p=0.222)	0.079 (p=0.436)	-0.280 (p=0.005)	0.439 (p<0.001)	0.257 (p=0.010)	-0.169 (p=0.092)	-0.176 (p=0.080)	-0.177 (p=0.078)	0.311 (p=0.002)	1.000 (p<0.001)	0.434 (p<0.001)	0.477 (p<0.001)	(p<0.001)	-0.685 (p<0.001)	0.599 (p<0.001)	0.104 (p=0.305)	-0.161 (p=0.110)
TaccP	-0.179 (p=0.075)	-0.192 (p=0.055)	0.360 (p<0.001)	-0.485 (p<0.001)	-0.188 (p=0.061)	0.320 (p=0.001)	0.292 (p=0.003)	0.310 (p=0.002)	-0.372 (p<0.001)	-0.685 (p<0.001)	-0.467 (p<0.001)	-0.488 (p<0.001)	-0.685 (p<0.001)	(p<0.001)	-0.708 (p<0.001)	-0.133 (p=0.188)	0.424 (p<0.001)
PAPm	0.144 (p=0.154)	0.083 (p=0.414)	-0.241 (p=0.016)	0.432 (p<0.001)	0.275 (p=0.006)	-0.306 (p=0.002)	-0.310 (p=0.002)	-0.315 (p=0.001)	0.421 (p<0.001)	0.599 (p<0.001)	0.491 (p<0.001)	0.501 (p<0.001)	0.599 (p<0.001)	-0.708 (p<0.001)	(p<0.001)	0.127 (p=0.209)	-0.228 (p=0.023)
VD (mm)	0.298 (p=0.003)	0.253 (p=0.011)	-0.092 (p=0.361)	0.303 (p=0.002)	0.074 (p=0.467)	0.005 (p=0.960)	-0.071 (p=0.484)	-0.050 (p=0.618)	0.061 (p=0.549)	0.104 (p=0.305)	0.320 (p=0.001)	0.241 (p=0.016)	0.104 (p=0.305)	-0.133 (p=0.188)	0.127 (p=0.209)	(p<0.001)	-0.190 (p=0.058)
TAPSE (mm)	-0.201 (p=0.045)	-0.180 (p=0.072)	0.133 (p=0.187)	-0.252 (p=0.011)	-0.010 (p=0.920)	0.135 (p=0.181)	0.118 (p=0.241)	0.133 (p=0.188)	-0.124 (p=0.219)	-0.161 (p=0.110)	-0.247 (p=0.013)	-0.279 (p=0.005)	-0.161 (p=0.110)	0.424 (p<0.001)	-0.228 (p=0.023)	-0.190 (p=0.058)	(p<0.001)

1.2 Strain 2D parameters

Table 2: .

Variable	Details	Total
N=		100
auto-EF	M (min:max)	46 (17:69)
	μ ±SD	43.63 ±10.9
GLS-2d	M (min:max)	-10.5 (-18:-2)
	μ ±SD	-10.10 ±3.89
ED mass	M (min:max)	105 (73:147)
	μ ±SD	104.04 ±13.9
PSD	M (min:max)	119 (16:353)
	μ ±SD	125.41 ±68.7
GWI	M (min:max)	957 (197:1902)
	μ ±SD	968.22 ±393.0
GWE	M (min:max)	83 (37:96)
	μ ±SD	80.53 ±10.8
CO	M (min:max)	3.3 (1.5:7.6)
	μ ±SD	3.48 ±1.06
Post-syst strain	M (min:max)	-10.5 (-18:-2)
	μ ±SD	-10.10 ±3.89
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

1.2.1 Correlograms

VS. (Spearman R)	auto-EF	GLS-2d	ED mass	PSD	GWI	GWE	CO	Post-syst strain
auto-EF	(p<0.001)	-0.673 (p<0.001)	-0.126 (p=0.210)	0.072 (p=0.478)	0.684 (p<0.001)	0.418 (p<0.001)	-0.072 (p=0.478)	-0.673 (p<0.001)
GLS-2d	-0.673 (p<0.001)	(p<0.001)	0.175 (p=0.082)	0.239 (p=0.017)	-0.814 (p<0.001)	-0.736 (p<0.001)	0.096 (p=0.342)	1.000 (p<0.001)
ED mass	-0.126 (p=0.210)	0.175 (p=0.082)	(p<0.001)	0.123 (p=0.221)	-0.193 (p=0.055)	-0.151 (p=0.133)	0.001 (p=0.994)	0.175 (p=0.082)
PSD	0.072 (p=0.478)	0.239 (p=0.017)	0.123 (p=0.221)	(p<0.001)	-0.253 (p=0.011)	-0.412 (p<0.001)	-0.085 (p=0.401)	0.239 (p=0.017)
GWI	0.684 (p<0.001)	-0.814 (p<0.001)	-0.193 (p=0.055)	-0.253 (p=0.011)	(p<0.001)	0.717 (p<0.001)	-0.059 (p=0.558)	-0.814 (p<0.001)
GWE	0.418 (p<0.001)	-0.736 (p<0.001)	-0.151 (p=0.133)	-0.412 (p<0.001)	0.717 (p<0.001)	(p<0.001)	-0.250 (p=0.012)	-0.736 (p<0.001)
CO	-0.072 (p=0.478)	0.096 (p=0.342)	0.001 (p=0.994)	-0.085 (p=0.401)	-0.059 (p=0.558)	-0.250 (p=0.012)	(p<0.001)	0.096 (p=0.342)
Post-syst strain	-0.673 (p<0.001)	1.000 (p<0.001)	0.175 (p=0.082)	0.239 (p=0.017)	-0.814 (p<0.001)	-0.736 (p<0.001)	0.096 (p=0.342)	(p<0.001)

1.3 Strain 3D parameters

Table 3: .

Variable	Details	Total
N=		100
3d-EF	M (min:max)	47.5 (17:70)
	μ ±SD	46.62 ±11.4
EDV	M (min:max)	115.5 (50:275)
	μ ±SD	116.59 ±37.2
ESV	M (min:max)	59 (23:182)
	μ ±SD	65.53 ±34.2
GLS-3d	M (min:max)	-9 (-20:-1)
	μ ±SD	-9.45 ±4.28
GCS-3d	M (min:max)	-10 (-26:-1)
	μ ±SD	-11.74 ±5.06
RADIAL	M (min:max)	24 (3:83)
	μ ±SD	26.62 ±15.8
TORSIUNE	M (min:max)	0.5 (-8:10)
	μ ±SD	0.411 ±2.16
GAS	M (min:max)	-17 (-35:-1)
	μ ±SD	-17.69 ±7.23
ROTATIE	M (min:max)	1.35 (-8.7:20.7)
	μ ±SD	2.09 ±6.31
LA Vmin	M (min:max)	31 (11:97)
	μ ±SD	31.86 ±15.4
LA Vmax	M (min:max)	55 (5:142)
	μ ±SD	58.39 ±23.6
LA VpreA	M (min:max)	43.5 (19:104)
	μ ±SD	47.68 ±20.2
LA EV	M (min:max)	23 (7:62)
	μ ±SD	27.01 ±14.5
LA EF	M (min:max)	46 (20:66)
	μ ±SD	45.51 ±13.0
LASr	M (min:max)	15 (-1:48)
	μ ±SD	15.19 ±7.29
LAScd	M (min:max)	-7 (-43:0)
	μ ±SD	-8.15 ±7.42
LASct	M (min:max)	-6 (-22:19)
	μ ±SD	-7.03 ±7.54
LASr_c	M (min:max)	18 (-2:55)
	μ ±SD	22.63 ±15.1
LAScd_c	M (min:max)	-8 (-30:2)
	μ ±SD	-8.27 ±6.15
LASct_c	M (min:max)	-8.5 (-55:12)
	μ ±SD	-14.33 ±17.0
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

1.3.1 Correlograms

VS. (Spearman R)	3d-EF	EDV	ESV	GLS-3d	GCS-3d	RADIAL	TORSIUNE	GAS	ROTATIE	LA Vmin	LA Vmax	LA VpreA	LA EV	LA EF	LASr	LAScd	LASct	LASr_c	LAScd_c	LASct_c
3d-EF	(p<0.001)	-0.525 (p<0.001)	-0.793 (p<0.001)	-0.587 (p<0.001)	-0.615 (p<0.001)	0.427 (p<0.001)	0.509 (p<0.001)	-0.633 (p<0.001)	0.337 (p<0.001)	-0.196 (p=0.051)	-0.105 (p=0.300)	-0.235 (p=0.018)	0.111 (p=0.270)	0.223 (p=0.026)	0.300 (p=0.002)	-0.457 (p<0.001)	0.042 (p=0.675)	0.086 (p=0.397)	-0.279 (p=0.005)	-0.020 (p=0.841)
EDV	-0.525 (p<0.001)	(p<0.001)	0.905 (p<0.001)	0.138 (p=0.172)	0.173 (p=0.086)	-0.092 (p=0.361)	-0.419 (p<0.001)	0.179 (p=0.075)	-0.375 (p<0.001)	0.146 (p=0.148)	0.144 (p=0.154)	0.207 (p=0.039)	0.119 (p=0.240)	0.000 (p=0.997)	-0.083 (p=0.410)	0.230 (p=0.021)	-0.034 (p=0.734)	0.037 (p=0.716)	0.146 (p=0.147)	-0.012 (p=0.902)
ESV	-0.793 (p<0.001)	0.905 (p<0.001)	(p<0.001)	0.342 (p<0.001)	0.389 (p<0.001)	-0.227 (p=0.023)	-0.513 (p<0.001)	0.395 (p<0.001)	-0.413 (p<0.001)	0.167 (p=0.096)	0.120 (p=0.233)	0.234 (p=0.019)	0.018 (p=0.856)	-0.099 (p=0.325)	-0.188 (p=0.062)	0.392 (p<0.001)	-0.078 (p=0.442)	0.009 (p=0.927)	0.227 (p=0.023)	-0.024 (p=0.814)
GLS-3d	-0.587 (p<0.001)	0.138 (p=0.172)	0.342 (p<0.001)	(p<0.001)	0.774 (p<0.001)	-0.706 (p<0.001)	-0.317 (p=0.001)	0.933 (p<0.001)	-0.130 (p=0.197)	0.170 (p=0.091)	0.084 (p=0.407)	0.169 (p=0.092)	-0.096 (p=0.342)	-0.167 (p=0.097)	-0.307 (p=0.002)	0.355 (p<0.001)	0.031 (p=0.763)	-0.149 (p=0.138)	0.233 (p=0.020)	0.074 (p=0.467)
GCS-3d	-0.615 (p<0.001)	0.173 (p=0.086)	0.389 (p<0.001)	0.774 (p<0.001)	(p<0.001)	-0.730 (p<0.001)	-0.423 (p<0.001)	0.918 (p<0.001)	-0.225 (p=0.024)	0.129 (p=0.200)	0.012 (p=0.904)	0.068 (p=0.504)	-0.205 (p=0.041)	-0.243 (p=0.015)	-0.293 (p=0.003)	0.253 (p=0.011)	0.056 (p=0.582)	-0.216 (p=0.031)	0.194 (p=0.053)	0.090 (p=0.376)
RADIAL	0.427 (p<0.001)	-0.092 (p=0.361)	-0.227 (p=0.023)	-0.706 (p<0.001)	-0.730 (p<0.001)	(p<0.001)	0.202 (p=0.044)	-0.755 (p<0.001)	0.042 (p=0.675)	-0.176 (p=0.080)	-0.143 (p=0.157)	-0.130 (p=0.197)	0.087 (p=0.388)	0.152 (p=0.130)	0.245 (p=0.014)	-0.161 (p=0.110)	-0.152 (p=0.130)	0.141 (p=0.163)	-0.127 (p=0.209)	-0.062 (p=0.540)
TORSIUNE	0.509 (p<0.001)	-0.419 (p<0.001)	-0.513 (p<0.001)	-0.317 (p=0.001)	-0.423 (p<0.001)	0.202 (p=0.044)	(p<0.001)	-0.423 (p<0.001)	0.845 (p<0.001)	-0.254 (p=0.011)	-0.222 (p=0.026)	-0.268 (p=0.007)	-0.003 (p=0.974)	0.212 (p=0.034)	0.256 (p=0.010)	-0.303 (p=0.002)	-0.048 (p=0.635)	0.076 (p=0.455)	-0.132 (p=0.192)	-0.058 (p=0.566)
GAS	-0.633 (p<0.001)	0.179 (p=0.075)	0.395 (p<0.001)	0.933 (p<0.001)	0.918 (p<0.001)	-0.755 (p<0.001)	-0.423 (p<0.001)	(p<0.001)	-0.243 (p=0.015)	0.166 (p=0.100)	0.065 (p=0.518)	0.156 (p=0.120)	-0.155 (p=0.125)	-0.220 (p=0.028)	-0.321 (p=0.001)	0.372 (p<0.001)	0.015 (p=0.881)	-0.177 (p=0.077)	0.263 (p=0.008)	0.061 (p=0.547)
ROTATIE	0.337 (p<0.001)	-0.375 (p<0.001)	-0.413 (p<0.001)	-0.130 (p=0.197)	-0.225 (p=0.024)	0.042 (p=0.675)	0.845 (p<0.001)	-0.243 (p=0.015)	(p<0.001)	-0.261 (p=0.009)	-0.185 (p=0.065)	-0.247 (p=0.013)	0.086 (p=0.393)	0.287 (p=0.004)	0.265 (p=0.008)	-0.277 (p=0.005)	-0.060 (p=0.553)	0.134 (p=0.183)	-0.207 (p=0.039)	-0.111 (p=0.272)
LA Vmin	-0.196 (p=0.051)	0.146 (p=0.148)	0.167 (p=0.096)	0.170 (p=0.091)	0.129 (p=0.200)	-0.176 (p=0.080)	-0.254 (p=0.011)	0.166 (p=0.100)	-0.261 (p=0.009)	(p<0.001)	0.861 (p<0.001)	0.810 (p<0.001)	0.337 (p<0.001)	-0.360 (p<0.001)	-0.444 (p<0.001)	0.300 (p=0.002)	0.339 (p<0.001)	-0.395 (p<0.001)	0.138 (p=0.171)	0.366 (p<0.001)
LA Vmax	-0.105 (p=0.300)	0.144 (p=0.154)	0.120 (p=0.233)	0.084 (p=0.407)	0.012 (p=0.904)	-0.143 (p=0.157)	-0.222 (p=0.026)	0.065 (p=0.518)	-0.185 (p=0.065)	0.861 (p<0.001)	(p<0.001)	0.878 (p<0.001)	0.678 (p<0.001)	0.070 (p=0.486)	-0.079 (p=0.432)	0.196 (p=0.051)	0.183 (p=0.068)	0.022 (p=0.828)	0.040 (p=0.695)	0.011 (p=0.911)
LA VpreA	-0.235 (p=0.018)	0.207 (p=0.039)	0.234 (p=0.019)	0.169 (p=0.092)	0.068 (p=0.504)	-0.130 (p=0.197)	-0.268 (p=0.007)	0.156 (p=0.120)	-0.247 (p=0.013)	0.810 (p<0.001)	0.878 (p<0.001)	(p<0.001)	0.629 (p<0.001)	0.050 (p=0.619)	-0.104 (p=0.304)	0.540 (p<0.001)	-0.098 (p=0.332)	0.072 (p=0.478)	0.423 (p<0.001)	-0.160 (p=0.111)
LA EV	0.111 (p=0.270)	0.119 (p=0.240)	0.018 (p=0.856)	-0.096 (p=0.342)	-0.205 (p=0.041)	0.087 (p=0.388)	-0.003 (p=0.974)	-0.155 (p=0.125)	0.086 (p=0.393)	0.337 (p<0.001)	0.678 (p<0.001)	0.629 (p<0.001)	(p<0.001)	0.712 (p<0.001)	0.418 (p<0.001)	-0.004 (p=0.965)	-0.132 (p=0.192)	0.565 (p<0.001)	-0.039 (p=0.702)	-0.468 (p<0.001)
LA EF	0.223 (p=0.026)	0.000 (p=0.997)	-0.099 (p=0.325)	-0.167 (p=0.097)	-0.243 (p=0.015)	0.152 (p=0.130)	0.212 (p=0.034)	-0.220 (p=0.028)	0.287 (p=0.004)	-0.360 (p<0.001)	0.070 (p=0.486)	0.050 (p=0.619)	0.712 (p<0.001)	(p<0.001)	0.776 (p<0.001)	-0.215 (p=0.032)	-0.361 (p<0.001)	0.845 (p<0.001)	-0.111 (p=0.271)	-0.738 (p<0.001)
LASr	0.300 (p=0.002)	-0.083 (p=0.410)	-0.188 (p=0.062)	-0.307 (p=0.002)	-0.293 (p=0.003)	0.245 (p=0.014)	0.256 (p=0.010)	-0.321 (p=0.001)	0.265 (p=0.008)	-0.444 (p<0.001)	-0.079 (p=0.432)	-0.104 (p=0.304)	0.418 (p<0.001)	0.776 (p<0.001)	(p<0.001)	-0.274 (p=0.006)	-0.540 (p<0.001)	0.745 (p<0.001)	-0.037 (p=0.713)	-0.755 (p<0.001)
LAScd	-0.457 (p<0.001)	0.230 (p=0.021)	0.392 (p<0.001)	0.355 (p<0.001)	0.253 (p=0.011)	-0.161 (p=0.110)	-0.303 (p=0.002)	0.372 (p<0.001)	-0.277 (p=0.005)	0.300 (p=0.002)	0.196 (p=0.051)	0.540 (p<0.001)	-0.004 (p=0.965)	-0.215 (p=0.032)	-0.274 (p=0.006)	(p<0.001)	-0.530 (p<0.001)	0.021 (p=0.834)	0.652 (p<0.001)	-0.186 (p=0.063)
LASct	0.042 (p=0.675)	-0.034 (p=0.734)	-0.078 (p=0.442)	0.031 (p=0.763)	0.056 (p=0.582)	-0.152 (p=0.130)	-0.048 (p=0.635)	0.015 (p=0.881)	-0.060 (p=0.553)	0.339 (p<0.001)	0.183 (p=0.068)	-0.098 (p=0.332)	-0.132 (p=0.192)	-0.361 (p<0.001)	-0.540 (p<0.001)	-0.530 (p<0.001)	(p<0.001)	-0.575 (p<0.001)	-0.428 (p<0.001)	0.711 (p<0.001)
LASr_c	0.086 (p=0.397)	0.037 (p=0.716)	0.009 (p=0.927)	-0.149 (p=0.138)	-0.216 (p=0.031)	0.141 (p=0.163)	0.076 (p=0.455)	-0.177 (p=0.077)	0.134 (p=0.183)	-0.395 (p<0.001)	0.022 (p=0.828)	0.072 (p=0.478)	0.565 (p<0.001)	0.845 (p<0.001)	0.745 (p<0.001)	0.021 (p=0.834)	-0.575 (p<0.001)	(p<0.001)	-0.045 (p=0.656)	-0.879 (p<0.001)
LAScd_c	-0.279 (p=0.005)	0.146 (p=0.147)	0.227 (p=0.023)	0.233 (p=0.020)	0.194 (p=0.053)	-0.127 (p=0.209)	-0.132 (p=0.192)	0.263 (p=0.008)	-0.207 (p=0.039)	0.138 (p=0.171)	0.040 (p=0.695)	0.423 (p<0.001)	-0.039 (p=0.702)	-0.111 (p=0.271)	-0.037 (p=0.713)	0.652 (p<0.001)	-0.428 (p<0.001)	-0.045 (p=0.656)	(p<0.001)	-0.317 (p=0.001)
LASct_c	-0.020 (p=0.841)	-0.012 (p=0.902)	-0.024 (p=0.814)	0.074 (p=0.467)	0.090 (p=0.376)	-0.062 (p=0.540)	-0.058 (p=0.566)	0.061 (p=0.547)	-0.111 (p=0.272)	0.366 (p<0.001)	0.011 (p=0.911)	-0.160 (p=0.111)	-0.468 (p<0.001)	-0.738 (p<0.001)	-0.755 (p<0.001)	-0.186 (p=0.063)	0.711 (p<0.001)	-0.879 (p<0.001)	-0.317 (p=0.001)	(p<0.001)

1.4 Classic VS. Strain 2D parameters

VS. (Spearman R)	auto-EF	GLS-2d	ED mass	PSD	GWI	GWE	CO	Post-syst strain
TD diamieter (mm)	-0.254 (p=0.011)	0.259 (p=0.009)	-0.051 (p=0.614)	-0.099 (p=0.329)	-0.301 (p=0.002)	-0.168 (p=0.094)	0.152 (p=0.130)	0.259 (p=0.009)
TS diamieter (mm)	-0.435 (p<0.001)	0.373 (p<0.001)	0.039 (p=0.697)	-0.001 (p=0.991)	-0.434 (p<0.001)	-0.240 (p=0.016)	0.170 (p=0.090)	0.373 (p<0.001)
LVEF (%)	0.799 (p<0.001)	-0.637 (p<0.001)	-0.094 (p=0.351)	-0.004 (p=0.968)	0.693 (p<0.001)	0.397 (p<0.001)	0.033 (p=0.741)	-0.637 (p<0.001)
LA diamieter	-0.149 (p=0.139)	0.206 (p=0.040)	-0.166 (p=0.100)	0.011 (p=0.917)	-0.148 (p=0.141)	-0.100 (p=0.320)	0.003 (p=0.980)	0.206 (p=0.040)
E	-0.118 (p=0.242)	0.086 (p=0.397)	-0.205 (p=0.041)	-0.090 (p=0.374)	-0.065 (p=0.518)	0.011 (p=0.911)	-0.081 (p=0.422)	0.086 (p=0.397)
e's	0.339 (p<0.001)	-0.195 (p=0.052)	-0.032 (p=0.754)	0.043 (p=0.670)	0.263 (p=0.008)	0.144 (p=0.152)	0.134 (p=0.182)	-0.195 (p=0.052)
e'l	0.365 (p<0.001)	-0.241 (p=0.016)	-0.030 (p=0.765)	0.062 (p=0.542)	0.317 (p=0.001)	0.219 (p=0.028)	0.097 (p=0.339)	-0.241 (p=0.016)
e'med	0.369 (p<0.001)	-0.230 (p=0.022)	-0.035 (p=0.731)	0.051 (p=0.613)	0.310 (p=0.002)	0.194 (p=0.053)	0.116 (p=0.252)	-0.230 (p=0.022)
E/e'	-0.387 (p<0.001)	0.235 (p=0.019)	-0.055 (p=0.584)	-0.113 (p=0.261)	-0.297 (p=0.003)	-0.142 (p=0.159)	-0.156 (p=0.121)	0.235 (p=0.019)
v max IT	-0.170 (p=0.090)	0.151 (p=0.134)	-0.142 (p=0.158)	-0.009 (p=0.931)	-0.131 (p=0.193)	-0.016 (p=0.871)	-0.108 (p=0.286)	0.151 (p=0.134)
vol AS	-0.216 (p=0.031)	0.261 (p=0.009)	-0.114 (p=0.259)	0.170 (p=0.091)	-0.240 (p=0.016)	-0.204 (p=0.041)	-0.054 (p=0.592)	0.261 (p=0.009)
vol ASi	-0.198 (p=0.049)	0.302 (p=0.002)	-0.182 (p=0.070)	0.186 (p=0.064)	-0.291 (p=0.003)	-0.261 (p=0.009)	-0.089 (p=0.380)	0.302 (p=0.002)
PSAP	-0.170 (p=0.090)	0.151 (p=0.134)	-0.142 (p=0.158)	-0.009 (p=0.931)	-0.131 (p=0.193)	-0.016 (p=0.871)	-0.108 (p=0.286)	0.151 (p=0.134)
TaccP	0.184 (p=0.067)	-0.276 (p=0.005)	0.063 (p=0.534)	-0.153 (p=0.129)	0.261 (p=0.009)	0.179 (p=0.075)	0.125 (p=0.213)	-0.276 (p=0.005)
PAPm	-0.079 (p=0.434)	0.130 (p=0.198)	-0.045 (p=0.657)	0.003 (p=0.973)	-0.068 (p=0.499)	-0.045 (p=0.653)	-0.221 (p=0.027)	0.130 (p=0.198)
VD (mm)	-0.126 (p=0.213)	0.180 (p=0.074)	0.085 (p=0.400)	0.120 (p=0.236)	-0.140 (p=0.165)	-0.171 (p=0.089)	0.070 (p=0.486)	0.180 (p=0.074)
TAPSE (mm)	0.059 (p=0.561)	-0.143 (p=0.156)	0.114 (p=0.257)	-0.209 (p=0.037)	0.167 (p=0.096)	0.177 (p=0.078)	0.086 (p=0.397)	-0.143 (p=0.156)

1.5 Classic VS. Strain 3D parameters

VS. (Spearman R)	3d-EF	EDV	ESV	GLS-3d	GCS-3d	RADIAL	TORSIUNE	GAS	ROTATIE	LA Vmin	LA Vmax	LA VpreA	LA EV	LA EF	LASr	LAScd	LASct	LASr_c	LAScd_c	LASct_c
TD diamieter (mm)	-0.252 (p=0.011)	0.350 (p<0.001)	0.351 (p<0.001)	0.200 (p=0.046)	0.190 (p=0.058)	-0.254 (p=0.011)	-0.216 (p=0.031)	0.209 (p=0.037)	-0.150 (p=0.136)	0.250 (p=0.012)	0.210 (p=0.036)	0.238 (p=0.017)	0.092 (p=0.361)	-0.098 (p=0.332)	-0.241 (p=0.016)	0.079 (p=0.436)	0.216 (p=0.031)	-0.105 (p=0.296)	0.124 (p=0.220)	0.075 (p=0.460)
TS diamieter (mm)	-0.387 (p<0.001)	0.523 (p<0.001)	0.528 (p<0.001)	0.319 (p=0.001)	0.311 (p=0.002)	-0.239 (p=0.017)	-0.340 (p<0.001)	0.344 (p<0.001)	-0.300 (p=0.002)	0.266 (p=0.008)	0.170 (p=0.090)	0.247 (p=0.013)	0.026 (p=0.798)	-0.153 (p=0.128)	-0.297 (p=0.003)	0.246 (p=0.014)	0.102 (p=0.313)	-0.159 (p=0.114)	0.230 (p=0.021)	0.127 (p=0.207)
LVEF (%)	0.808 (p<0.001)	-0.467 (p<0.001)	-0.672 (p<0.001)	-0.561 (p<0.001)	-0.617 (p<0.001)	0.429 (p<0.001)	0.409 (p<0.001)	-0.608 (p<0.001)	0.238 (p=0.017)	-0.133 (p=0.187)	-0.066 (p=0.514)	-0.162 (p=0.108)	0.135 (p=0.182)	0.195 (p=0.051)	0.292 (p=0.003)	-0.394 (p<0.001)	0.038 (p=0.708)	0.065 (p=0.520)	-0.189 (p=0.059)	-0.072 (p=0.479)
LA diamieter	-0.187 (p=0.063)	0.214 (p=0.032)	0.257 (p=0.010)	0.075 (p=0.458)	0.041 (p=0.683)	-0.093 (p=0.355)	-0.161 (p=0.109)	0.079 (p=0.437)	-0.178 (p=0.077)	0.420 (p<0.001)	0.370 (p<0.001)	0.396 (p<0.001)	0.031 (p=0.761)	-0.239 (p=0.017)	-0.229 (p=0.022)	0.310 (p=0.002)	0.095 (p=0.345)	-0.165 (p=0.101)	0.208 (p=0.038)	0.111 (p=0.272)
E	-0.156 (p=0.121)	0.000 (p=0.998)	0.063 (p=0.535)	0.104 (p=0.302)	-0.014 (p=0.892)	-0.025 (p=0.808)	-0.077 (p=0.444)	0.030 (p=0.768)	0.012 (p=0.902)	0.236 (p=0.018)	0.221 (p=0.027)	0.299 (p=0.003)	0.178 (p=0.076)	0.006 (p=0.949)	-0.136 (p=0.178)	0.216 (p=0.031)	0.013 (p=0.895)	0.010 (p=0.924)	0.100 (p=0.321)	-0.029 (p=0.774)
e's	0.414 (p<0.001)	-0.106 (p=0.294)	-0.237 (p=0.018)	-0.293 (p=0.003)	-0.215 (p=0.032)	0.156 (p=0.122)	0.286 (p=0.004)	-0.294 (p=0.003)	0.287 (p=0.004)	-0.303 (p=0.002)	-0.176 (p=0.079)	-0.271 (p=0.006)	0.139 (p=0.167)	0.330 (p<0.001)	0.338 (p<0.001)	-0.392 (p<0.001)	-0.019 (p=0.850)	0.195 (p=0.051)	-0.215 (p=0.032)	-0.176 (p=0.081)
e'l	0.415 (p<0.001)	-0.151 (p=0.135)	-0.266 (p=0.007)	-0.372 (p<0.001)	-0.239 (p=0.016)	0.180 (p=0.074)	0.284 (p=0.004)	-0.331 (p<0.001)	0.286 (p=0.004)	-0.242 (p=0.015)	-0.125 (p=0.216)	-0.228 (p=0.022)	0.121 (p=0.229)	0.240 (p=0.016)	0.227 (p=0.023)	-0.338 (p<0.001)	-0.037 (p=0.715)	0.165 (p=0.102)	-0.267 (p=0.007)	-0.110 (p=0.276)
e'med	0.430 (p<0.001)	-0.145 (p=0.151)	-0.269 (p=0.007)	-0.358 (p<0.001)	-0.243 (p=0.015)	0.180 (p=0.074)	0.300 (p=0.002)	-0.332 (p<0.001)	0.300 (p=0.002)	-0.263 (p=0.008)	-0.143 (p=0.155)	-0.247 (p=0.013)	0.135 (p=0.179)	0.281 (p=0.005)	0.274 (p=0.006)	-0.372 (p<0.001)	-0.020 (p=0.840)	0.176 (p=0.081)	-0.253 (p=0.011)	-0.130 (p=0.196)
E/e'	-0.454 (p<0.001)	0.129 (p=0.202)	0.272 (p=0.006)	0.355 (p<0.001)	0.229 (p=0.022)	-0.197 (p=0.050)	-0.306 (p=0.002)	0.307 (p=0.002)	-0.230 (p=0.021)	0.365 (p<0.001)	0.257 (p=0.010)	0.384 (p<0.001)	0.005 (p=0.963)	-0.224 (p=0.025)	-0.334 (p<0.001)	0.429 (p<0.001)	0.040 (p=0.692)	-0.131 (p=0.193)	0.246 (p=0.014)	0.089 (p=0.379)
v max IT	-0.159 (p=0.114)	-0.009 (p=0.930)	0.088 (p=0.384)	0.239 (p=0.017)	0.236 (p=0.018)	-0.218 (p=0.029)	-0.069 (p=0.498)	0.234 (p=0.019)	-0.043 (p=0.670)	0.333 (p<0.001)	0.303 (p=0.002)	0.316 (p=0.001)	0.137 (p=0.174)	-0.081 (p=0.422)	-0.178 (p=0.076)	0.221 (p=0.027)	0.039 (p=0.699)	-0.041 (p=0.685)	0.050 (p=0.618)	0.062 (p=0.539)
vol AS	-0.277 (p=0.005)	0.277 (p=0.005)	0.308 (p=0.002)	0.277 (p=0.005)	0.202 (p=0.044)	-0.142 (p=0.159)	-0.292 (p=0.003)	0.263 (p=0.008)	-0.280 (p=0.005)	0.373 (p<0.001)	0.462 (p<0.001)	0.502 (p<0.001)	0.318 (p=0.001)	0.087 (p=0.389)	-0.044 (p=0.667)	0.331 (p<0.001)	-0.063 (p=0.532)	0.141 (p=0.163)	0.190 (p=0.058)	-0.116 (p=0.250)
vol ASi	-0.255 (p=0.010)	0.167 (p=0.097)	0.206 (p=0.040)	0.288 (p=0.004)	0.212 (p=0.034)	-0.184 (p=0.066)	-0.251 (p=0.012)	0.280 (p=0.005)	-0.256 (p=0.010)	0.470 (p<0.001)	0.495 (p<0.001)	0.546 (p<0.001)	0.270 (p=0.007)	-0.026 (p=0.795)	-0.133 (p=0.188)	0.343 (p<0.001)	-0.009 (p=0.931)	0.015 (p=0.880)	0.191 (p=0.058)	0.009 (p=0.931)
PSAP	-0.159 (p=0.114)	-0.009 (p=0.930)	0.088 (p=0.384)	0.239 (p=0.017)	0.236 (p=0.018)	-0.218 (p=0.029)	-0.069 (p=0.498)	0.234 (p=0.019)	-0.043 (p=0.670)	0.333 (p<0.001)	0.303 (p=0.002)	0.316 (p=0.001)	0.137 (p=0.174)	-0.081 (p=0.422)	-0.178 (p=0.076)	0.221 (p=0.027)	0.039 (p=0.699)	-0.041 (p=0.685)	0.050 (p=0.618)	0.062 (p=0.539)
TaccP	0.209 (p=0.037)	-0.005 (p=0.963)	-0.133 (p=0.186)	-0.257 (p=0.010)	-0.230 (p=0.021)	0.219 (p=0.029)	0.201 (p=0.045)	-0.251 (p=0.012)	0.192 (p=0.055)	-0.305 (p=0.002)	-0.234 (p=0.019)	-0.265 (p=0.008)	0.052 (p=0.604)	0.244 (p=0.014)	0.327 (p<0.001)	-0.292 (p=0.003)	-0.078 (p=0.438)	0.134 (p=0.184)	-0.115 (p=0.254)	-0.153 (p=0.129)
PAPm	-0.134 (p=0.184)	-0.153 (p=0.127)	-0.046 (p=0.649)	0.212 (p=0.035)	0.117 (p=0.245)	-0.185 (p=0.066)	-0.112 (p=0.269)	0.176 (p=0.079)	-0.105 (p=0.298)	0.347 (p<0.001)	0.338 (p<0.001)	0.343 (p<0.001)	0.118 (p=0.243)	-0.097 (p=0.339)	-0.221 (p=0.027)	0.176 (p=0.079)	0.142 (p=0.159)	-0.003 (p=0.975)	0.071 (p=0.480)	0.048 (p=0.633)
VD (mm)	-0.077 (p=0.447)	0.217 (p=0.030)	0.205 (p=0.040)	0.038 (p=0.708)	0.004 (p=0.966)	-0.102 (p=0.311)	-0.112 (p=0.269)	0.021 (p=0.832)	-0.100 (p=0.324)	0.133 (p=0.187)	0.175 (p=0.082)	0.147 (p=0.144)	0.066 (p=0.517)	-0.048 (p=0.638)	-0.134 (p=0.184)	0.087 (p=0.389)	0.124 (p=0.218)	-0.050 (p=0.621)	0.010 (p=0.924)	0.108 (p=0.283)
TAPSE (mm)	0.110 (p=0.276)	0.004 (p=0.967)	-0.082 (p=0.416)	-0.169 (p=0.094)	-0.124 (p=0.218)	0.176 (p=0.081)	0.152 (p=0.130)	-0.157 (p=0.118)	0.145 (p=0.150)	-0.186 (p=0.064)	-0.172 (p=0.087)	-0.151 (p=0.132)	-0.015 (p=0.882)	0.097 (p=0.337)	0.179 (p=0.075)	-0.055 (p=0.584)	-0.151 (p=0.134)	0.055 (p=0.585)	0.007 (p=0.946)	-0.079 (p=0.437)

1.6 Strain 2D VS. Strain 3D parameters

VS. (Spearman R)	auto-EF	GLS-2d	ED mass	PSD	GWI	GWE	CO	Post-syst strain
3d-EF	0.846 (p<0.001)	-0.513 (p<0.001)	-0.125 (p=0.214)	0.063 (p=0.535)	0.598 (p<0.001)	0.305 (p=0.002)	0.126 (p=0.213)	-0.513 (p<0.001)
EDV	-0.556 (p<0.001)	0.334 (p<0.001)	-0.100 (p=0.323)	-0.055 (p=0.585)	-0.379 (p<0.001)	-0.238 (p=0.017)	0.370 (p<0.001)	0.334 (p<0.001)
ESV	-0.744 (p<0.001)	0.446 (p<0.001)	0.004 (p=0.971)	-0.062 (p=0.537)	-0.535 (p<0.001)	-0.302 (p=0.002)	0.217 (p=0.030)	0.446 (p<0.001)
GLS-3d	-0.572 (p<0.001)	0.578 (p<0.001)	0.116 (p=0.252)	0.175 (p=0.082)	-0.665 (p<0.001)	-0.517 (p<0.001)	-0.039 (p=0.700)	0.578 (p<0.001)
GCS-3d	-0.612 (p<0.001)	0.497 (p<0.001)	0.173 (p=0.086)	0.112 (p=0.269)	-0.593 (p<0.001)	-0.411 (p<0.001)	-0.032 (p=0.749)	0.497 (p<0.001)
RADIAL	0.433 (p<0.001)	-0.411 (p<0.001)	-0.063 (p=0.533)	-0.061 (p=0.547)	0.473 (p<0.001)	0.393 (p<0.001)	0.082 (p=0.416)	-0.411 (p<0.001)
TORSIUNE	0.462 (p<0.001)	-0.308 (p=0.002)	-0.031 (p=0.761)	-0.022 (p=0.831)	0.393 (p<0.001)	0.233 (p=0.019)	-0.022 (p=0.825)	-0.308 (p=0.002)
GAS	-0.615 (p<0.001)	0.578 (p<0.001)	0.157 (p=0.119)	0.163 (p=0.105)	-0.688 (p<0.001)	-0.516 (p<0.001)	-0.038 (p=0.707)	0.578 (p<0.001)
ROTATIE	0.339 (p<0.001)	-0.197 (p=0.049)	0.031 (p=0.757)	0.045 (p=0.660)	0.282 (p=0.004)	0.132 (p=0.190)	0.013 (p=0.897)	-0.197 (p=0.049)
LA Vmin	-0.189 (p=0.059)	0.173 (p=0.086)	-0.199 (p=0.047)	-0.022 (p=0.825)	-0.193 (p=0.055)	-0.092 (p=0.364)	-0.055 (p=0.583)	0.173 (p=0.086)
LA Vmax	-0.087 (p=0.392)	0.124 (p=0.218)	-0.196 (p=0.051)	0.036 (p=0.719)	-0.142 (p=0.159)	-0.080 (p=0.427)	-0.079 (p=0.432)	0.124 (p=0.218)
LA VpreA	-0.194 (p=0.053)	0.188 (p=0.061)	-0.154 (p=0.125)	0.018 (p=0.862)	-0.208 (p=0.038)	-0.084 (p=0.405)	-0.098 (p=0.333)	0.188 (p=0.061)
LA EV	0.122 (p=0.225)	-0.085 (p=0.399)	-0.075 (p=0.458)	0.020 (p=0.843)	0.089 (p=0.380)	0.056 (p=0.577)	0.036 (p=0.723)	-0.085 (p=0.399)
LA EF	0.239 (p=0.017)	-0.208 (p=0.037)	0.032 (p=0.755)	0.034 (p=0.733)	0.187 (p=0.062)	0.127 (p=0.208)	-0.043 (p=0.674)	-0.208 (p=0.037)
LASr	0.272 (p=0.006)	-0.268 (p=0.007)	-0.044 (p=0.667)	0.038 (p=0.704)	0.259 (p=0.009)	0.184 (p=0.067)	0.062 (p=0.541)	-0.268 (p=0.007)
LAScd	-0.424 (p<0.001)	0.305 (p=0.002)	-0.018 (p=0.857)	0.108 (p=0.286)	-0.363 (p<0.001)	-0.208 (p=0.038)	-0.094 (p=0.353)	0.305 (p=0.002)
LASct	0.076 (p=0.455)	0.032 (p=0.755)	-0.004 (p=0.967)	-0.123 (p=0.222)	-0.003 (p=0.978)	-0.048 (p=0.634)	-0.018 (p=0.857)	0.032 (p=0.755)
LASr_c	0.122 (p=0.227)	-0.186 (p=0.064)	-0.002 (p=0.984)	0.045 (p=0.659)	0.107 (p=0.290)	0.119 (p=0.237)	-0.012 (p=0.905)	-0.186 (p=0.064)
LAScd_c	-0.260 (p=0.009)	0.232 (p=0.020)	0.072 (p=0.479)	0.006 (p=0.955)	-0.177 (p=0.077)	-0.072 (p=0.474)	-0.073 (p=0.471)	0.232 (p=0.020)
LASct_c	-0.061 (p=0.549)	0.114 (p=0.260)	-0.063 (p=0.534)	-0.010 (p=0.924)	-0.071 (p=0.480)	-0.119 (p=0.238)	0.046 (p=0.651)	0.114 (p=0.260)

1.7 General descriptions

Table 4: General descriptions.

Variable	Details	Total
N=		100
Diagnosis	STEMI	69 (69.0%)
	NSTEMI	31 (31.0%)
Onset hour	M (min:max)	8 (1:72)
	μ ±SD	12.01 ±12.4
Age (years)	M (min:max)	68 (35:97)
	μ ±SD	67.07 ±13.2
Sex	F	42 (42.4%)
	M	57 (57.6%)
Weight (kg)	M (min:max)	82 (40:120)
	μ ±SD	81.43 ±14.9
Height (cm)	M (min:max)	168 (145:195)
	μ ±SD	167.17 ±7.78
BMI (kg/m2)	M (min:max)	29.58 (15.62:42.81)
	μ ±SD	29.12 ±4.97
BSA	M (min:max)	1.96 (1.29:2.46)
	μ ±SD	1.94 ±0.205
Residence	rural	34 (34.3%)
	urban	65 (65.7%)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

1.7.1 Risk factors

Table 5: Risk factors.

Variable	Details	Total
N=		100
Smoking		39 (39.0%)
Alcohol		13 (13.0%)
Coffee		17 (17.0%)
Physical activity	sedentary	16 (16.2%)
	easy activities	28 (28.3%)
	moderate activities	34 (34.3%)
	hard activities	21 (21.2%)
HBP	no	24 (24.0%)
	gr1	11 (11.0%)
	gr2	38 (38.0%)
	gr3	27 (27.0%)
DM	no	69 (69.0%)
	ADO	18 (18.0%)
	insulin	13 (13.0%)
Dyslipidemia		28 (28.0%)
Family history		8 (8.0%)
Thyroid disfunction	no	90 (90.0%)
	hypothyroidism	7 (7.0%)
	hiperthyroidism	3 (3.0%)
BRC	no	92 (92.0%)
	0	1 (1.0%)
	1	3 (3.0%)
	2	3 (3.0%)
	3	1 (1.0%)
	4	0
AP		42 (42.0%)
ACOMI		10 (10.0%)
AF	no	93 (93.0%)
	paroxysmal	1 (1.0%)
	persistent	1 (1.0%)
	permanent	5 (5.0%)
Valvulopathy > moderate	0	79 (79.0%)
	1	19 (19.0%)
	2	2 (2.0%)
Cancer		5 (5.0%)

1.7.2 Treatment (pre-intervention)

Table 6: Treatment (pre-intervention).

Variable	Details	Total
N=		100
Aspirine (pre)		19 (19.0%)
Second (pre)		3 (3.0%)
Betablockers (pre)		22 (22.0%)
Statins (pre)		11 (11.0%)
IECA/ARB (pre)	no	73 (73.0%)
	IECA	23 (23.0%)
	ARB	4 (4.0%)
Spironolactone (pre)		4 (4.0%)
Furosemid (pre)		6 (6.0%)
Digoxin (pre)		2 (2.0%)
Amiod (pre)		1 (1.0%)
AC (pre)		3 (3.0%)
Euthyrox / tyrozol (pre)	no	93 (93.0%)
	euthyrox	5 (5.0%)
	tyrozol	2 (2.0%)

1.7.3 Treatment

Table 7: Treatment.

Variable	Details	Total
N=		100
necesar inotrop	0	76 (76.0%)
	NA	6 (6.0%)
	dopamne	0
	dobutamine	0
	association	18 (18.0%)
Aspirine		98 (98.0%)
Second		63 (63.0%)
Statins		97 (97.0%)
Betablockers	0	28 (28.0%)
	Metoprolol	23 (23.0%)
	Bisoprolol	45 (45.0%)
	nebivolol	2 (2.0%)
	4	2 (2.0%)
IECA/ARB	0	31 (31.0%)
	Perindopril	57 (57.0%)
	Candesartan	12 (12.0%)
Digoxin		5 (5.0%)
Corlentor		2 (2.0%)
AC		7 (7.0%)
Spironolactone		19 (19.0%)
Furosemid		22 (22.0%)
Amiod		11 (11.0%)

1.7.4 Symptoms

Table 8: Symptoms.

Variable	Details	Total
N=		100
Symptoms	pain	75 (75.8%)
	dyspnea	2 (2.0%)
	syncope	1 (1.0%)
	perspiration	0
	vomiting	2 (2.0%)
	palpitations	0
	>2	15 (15.2%)
	>3	4 (4.0%)
SBP	M (min:max)	130 (60:230)
	μ ±SD	131.14 ±27.1
DBP	M (min:max)	72.5 (40:110)
	μ ±SD	75.31 ±15.6
HR	M (min:max)	80 (30:140)
	μ ±SD	78.43 ±18.5
SaO2	M (min:max)	97 (70:100)
	μ ±SD	95.64 ±4.25
raluri staza		53 (53.0%)
Periferic edema		16 (16.0%)
ICC NYHA	0	1 (1.0%)
	1	39 (39.0%)
	2	28 (28.0%)
	3	12 (12.0%)
	4	20 (20.0%)
Pneumonia		5 (8.9%)
CRP	M (min:max)	0 (0:247)
	μ ±SD	13.48 ±49.7
Readmissions	0	88 (88.0%)
	1	10 (10.0%)
	2	2 (2.0%)
Readmission cause	STEMI intrastent	1 (8.3%)
	NSTEMI intrastent	3 (25.0%)
	STEMI other vessel	1 (8.3%)
	NSTEMI other vessel	7 (58.3%)
	IC	0
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

1.7.5 Coronarography

Table 9: Coronarography.

Variable	Details	Total
N=		100
Time to coronarography (min)	M (min:max)	60 (15:4800)
	μ ±SD	266.35 ±750.0
Blood vessel	iva	44 (44.0%)
	CD	35 (35.0%)
	cx	14 (14.0%)
	0	4 (4.0%)
	tp	3 (3.0%)
Blood vessels	0	4 (4.0%)
	1	41 (41.0%)
	2	28 (28.0%)
	3	27 (27.0%)
Indication	PCI	80 (80.0%)
	chir	7 (7.0%)
	med	12 (12.0%)
	0	1 (1.0%)
Stents	0	28 (28.0%)
	1	42 (42.0%)
	2	26 (26.0%)
	3	4 (4.0%)
flux TIMI	0	16 (16.0%)
	1	2 (2.0%)
	2	12 (12.0%)
	3	70 (70.0%)
Residual lesions	nu	87 (87.0%)
	in aceeasi coro	2 (2.0%)
	coro dif aceeasi int	11 (11.0%)
Complications after coronarography	none	57 (57.0%)
	hematoma	3 (3.0%)
	HBP	4 (4.0%)
	bradycardia	8 (8.0%)
	tachycardia	4 (4.0%)
	AF	3 (3.0%)
	SCR	10 (10.0%)
	death	11 (11.0%)
bav		7 (7.0%)
EPA		9 (9.0%)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

1.7.6 ECG

Table 10: ECG.

Variable	Details	Total
N=		100
Rhythm	RS	89 (89.0%)
	FiA	9 (9.0%)
	BAV	2 (2.0%)
Axis	no	77 (77.0%)
	left	22 (22.0%)
	right	1 (1.0%)
supra max	M (min:max)	1 (0:8)
	μ ±SD	1.50 ±1.75
Teritory	ant	24 (25.3%)
	lat	9 (9.5%)
	ant-lat	21 (22.1%)
	inf	29 (30.5%)
	inf-la	6 (6.3%)
	latt	6 (6.3%)
ExSV	no	86 (86.9%)
	isolated	4 (4.0%)
	pase	9 (9.1%)
ExV	no	81 (81.0%)
	isolated	5 (5.0%)
	bigeminal	3 (3.0%)
	TVns	5 (5.0%)
	TVs	6 (6.0%)
rezolutie 1h post coro	no	31 (31.0%)
	<1/2	15 (15.0%)
	>1/2	18 (18.0%)
	complete	36 (36.0%)
RIVA post coro		2 (2.0%)
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

1.7.7 Laboratory parameters

Table 11: Laboratory parameters.

Variable	Details	Total
N=		100
Troponine (ng/mL)	M (min:max)	0.26 (0.01:9.71)
	μ ±SD	0.892 ±1.68
CK (IU/L)	M (min:max)	237 (25:5299)
	μ ±SD	428.56 ±646.3
CK-MB (IU/L)	M (min:max)	37.5 (7:520)
	μ ±SD	60.05 ±72.7
NT-proBNP (IU/L)	M (min:max)	575 (30:6000)
	μ ±SD	1134.95 ±1355.4
ANP (IU/L)	M (min:max)	51.5 (6:230)
	μ ±SD	67.28 ±54.6
Fetuin A (IU/L)	M (min:max)	155 (20:900)
	μ ±SD	194.30 ±146.3
Total cholesterol (mg/dL)	M (min:max)	176.35 (74:358)
	μ ±SD	183.19 ±51.1
LDL (mg/dL)	M (min:max)	100 (35:293)
	μ ±SD	109.47 ±45.7
HDL (mg/dL)	M (min:max)	40 (20.1:79.3)
	μ ±SD	42.54 ±11.5
Triglycerides (mg/dL)	M (min:max)	141.4 (33.1:383)
	μ ±SD	155.36 ±80.4
TSH (mIU/L)	M (min:max)	2.27 (0.02:24)
	μ ±SD	4.20 ±6.34
FT4	M (min:max)	16.3 (0.9:18)
	μ ±SD	13.92 ±5.76
Creatinine (mg/dL)	M (min:max)	0.93 (0.52:9.35)
	μ ±SD	1.17 ±1.06
Urea (mg/dL)	M (min:max)	38.8 (13.5:159.7)
	μ ±SD	44.58 ±24.5
[Unknown]	M (min:max)	5871.5 (2200:11040)
	μ ±SD	5992.37 ±1710.0
eGFR (Cockroft)	M (min:max)	84.49 (5.79:205.76)
	μ ±SD	88.86 ±40.2
Creatinine post-coronarography (mg/dL)	M (min:max)	0.95 (0.61:9.81)
	μ ±SD	1.27 ±1.39
eGFR post-coronarography	M (min:max)	84.29 (5.52:165.16)
	μ ±SD	82.76 ±35.2
Na⁺ (mEq/mL)	M (min:max)	139 (124:145)
	μ ±SD	138.48 ±3.85
K⁺ (mEq/mL)	M (min:max)	4.2 (2.53:7.4)
	μ ±SD	4.21 ±0.613
ASAT (IU/L)	M (min:max)	36.5 (3:520)
	μ ±SD	61.53 ±79.2
ALAT (IU/L)	M (min:max)	24.5 (6:222)
	μ ±SD	33.22 ±31.7
Glucose (mg/dL)	M (min:max)	121.5 (69.4:345)
	μ ±SD	137.06 ±49.9
Hemoglobin (mg/dL)	M (min:max)	13.6 (8.3:18.4)
	μ ±SD	13.52 ±1.86
Hematocrite (%)	M (min:max)	41 (26:52)
	μ ±SD	40.72 ±5.12
WBC (10³/ µl)	M (min:max)	11.18 (3.6:98.7)
	μ ±SD	16.32 ±18.7
Neutrophiles (%)	M (min:max)	72.5 (47:93.2)
	μ ±SD	71.70 ±12.1
Eosinophiles (%)	M (min:max)	0.6 (0:5.2)
	μ ±SD	0.968 ±1.03
Platelets (10³/ µl)	M (min:max)	227.5 (112:418)
	μ ±SD	237.75 ±67.8
INR	M (min:max)	1.09 (0.86:2.2)
	μ ±SD	1.13 ±0.179
APTT (seconds)	M (min:max)	35 (11:185.5)
	μ ±SD	47.28 ±37.0
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max);

Min. 1st Qu. Median Mean 3rd Qu. Max. 30 180 575 1135 1638 6000 [1] 0.008

1.7.7.1 Vs. Echo

VS. (Spearman R)	TD diamieter (mm)	TS diamieter (mm)	LVEF (%)	LA diamieter	E	e's	e'l	e'med	E/e'	v max IT	vol AS	vol ASi	PSAP	TaccP	PAPm	VD (mm)	TAPSE (mm)
Troponine (ng/mL)	0.076 (p=0.451)	0.085 (p=0.402)	-0.260 (p=0.009)	0.082 (p=0.416)	-0.101 (p=0.318)	-0.069 (p=0.494)	-0.058 (p=0.567)	-0.061 (p=0.544)	0.030 (p=0.767)	0.182 (p=0.071)	-0.072 (p=0.476)	-0.035 (p=0.731)	0.182 (p=0.071)	-0.133 (p=0.187)	0.127 (p=0.207)	0.098 (p=0.330)	-0.123 (p=0.222)
CK (IU/L)	-0.015 (p=0.883)	0.014 (p=0.890)	-0.211 (p=0.035)	0.035 (p=0.730)	-0.072 (p=0.476)	-0.018 (p=0.859)	-0.079 (p=0.433)	-0.054 (p=0.593)	0.036 (p=0.722)	0.165 (p=0.100)	-0.007 (p=0.947)	-0.016 (p=0.876)	0.165 (p=0.100)	-0.051 (p=0.617)	0.083 (p=0.414)	0.004 (p=0.966)	-0.026 (p=0.797)
CK-MB (IU/L)	-0.093 (p=0.359)	0.008 (p=0.940)	-0.157 (p=0.118)	0.036 (p=0.724)	-0.068 (p=0.500)	-0.042 (p=0.679)	-0.067 (p=0.511)	-0.055 (p=0.588)	0.037 (p=0.712)	0.150 (p=0.137)	0.025 (p=0.802)	0.046 (p=0.651)	0.150 (p=0.137)	-0.129 (p=0.200)	0.136 (p=0.176)	-0.004 (p=0.971)	-0.022 (p=0.826)
NT-proBNP (IU/L)	0.297 (p=0.003)	0.286 (p=0.004)	-0.305 (p=0.002)	0.146 (p=0.146)	0.083 (p=0.414)	-0.126 (p=0.212)	-0.093 (p=0.358)	-0.108 (p=0.283)	0.117 (p=0.246)	0.167 (p=0.096)	0.047 (p=0.640)	0.115 (p=0.254)	0.167 (p=0.096)	-0.338 (p<0.001)	0.387 (p<0.001)	0.061 (p=0.545)	-0.080 (p=0.429)
ANP (IU/L)	0.271 (p=0.006)	0.303 (p=0.002)	-0.260 (p=0.009)	0.191 (p=0.057)	0.001 (p=0.989)	-0.235 (p=0.019)	-0.133 (p=0.186)	-0.173 (p=0.085)	0.124 (p=0.218)	0.205 (p=0.041)	0.104 (p=0.302)	0.153 (p=0.128)	0.205 (p=0.041)	-0.341 (p<0.001)	0.273 (p=0.006)	0.152 (p=0.130)	-0.125 (p=0.217)
Fetuin A (IU/L)	-0.116 (p=0.250)	-0.165 (p=0.102)	0.119 (p=0.237)	-0.082 (p=0.420)	-0.060 (p=0.550)	0.073 (p=0.469)	0.108 (p=0.284)	0.096 (p=0.344)	-0.093 (p=0.356)	-0.060 (p=0.554)	-0.046 (p=0.653)	-0.056 (p=0.578)	-0.060 (p=0.554)	0.203 (p=0.043)	-0.335 (p<0.001)	-0.084 (p=0.408)	-0.011 (p=0.910)
Total cholesterol (mg/dL)	0.074 (p=0.466)	-0.044 (p=0.664)	0.106 (p=0.294)	-0.176 (p=0.080)	-0.016 (p=0.872)	0.049 (p=0.627)	0.048 (p=0.635)	0.041 (p=0.685)	-0.036 (p=0.719)	-0.076 (p=0.454)	0.018 (p=0.860)	-0.009 (p=0.933)	-0.076 (p=0.454)	0.097 (p=0.337)	-0.164 (p=0.104)	0.004 (p=0.972)	0.004 (p=0.966)

VS. (Spearman R)	auto-EF	GLS-2d	ED mass	PSD	GWI	GWE	CO	Post-syst strain
Troponine (ng/mL)	-0.189 (p=0.060)	0.220 (p=0.028)	0.016 (p=0.878)	0.027 (p=0.792)	-0.203 (p=0.043)	-0.173 (p=0.085)	0.032 (p=0.751)	0.220 (p=0.028)
CK (IU/L)	-0.173 (p=0.086)	0.123 (p=0.224)	0.000 (p=0.997)	0.085 (p=0.401)	-0.165 (p=0.100)	-0.147 (p=0.145)	-0.050 (p=0.621)	0.123 (p=0.224)
CK-MB (IU/L)	-0.114 (p=0.257)	0.102 (p=0.315)	0.046 (p=0.649)	0.101 (p=0.318)	-0.146 (p=0.148)	-0.046 (p=0.646)	-0.117 (p=0.248)	0.102 (p=0.315)
NT-proBNP (IU/L)	-0.236 (p=0.018)	0.316 (p=0.001)	-0.068 (p=0.504)	0.032 (p=0.755)	-0.260 (p=0.009)	-0.158 (p=0.117)	0.014 (p=0.892)	0.316 (p=0.001)
ANP (IU/L)	-0.165 (p=0.101)	0.194 (p=0.053)	-0.007 (p=0.943)	0.114 (p=0.257)	-0.210 (p=0.036)	-0.090 (p=0.373)	-0.040 (p=0.690)	0.194 (p=0.053)
Fetuin A (IU/L)	0.136 (p=0.176)	-0.031 (p=0.761)	0.085 (p=0.399)	0.107 (p=0.290)	0.043 (p=0.668)	-0.038 (p=0.707)	-0.031 (p=0.759)	-0.031 (p=0.761)
Total cholesterol (mg/dL)	0.129 (p=0.200)	0.023 (p=0.821)	-0.010 (p=0.925)	0.172 (p=0.087)	-0.015 (p=0.884)	-0.131 (p=0.192)	0.118 (p=0.244)	0.023 (p=0.821)

VS. (Spearman R)	Troponine (ng/mL)	CK (IU/L)	CK-MB (IU/L)	NT-proBNP (IU/L)	ANP (IU/L)	Fetuin A (IU/L)	Total cholesterol (mg/dL)
Troponine (ng/mL)	(p<0.001)	0.652 (p<0.001)	0.578 (p<0.001)	0.386 (p<0.001)	0.268 (p=0.007)	-0.066 (p=0.517)	-0.029 (p=0.775)
CK (IU/L)	0.652 (p<0.001)	(p<0.001)	0.829 (p<0.001)	0.099 (p=0.329)	0.074 (p=0.464)	0.043 (p=0.672)	0.128 (p=0.203)
CK-MB (IU/L)	0.578 (p<0.001)	0.829 (p<0.001)	(p<0.001)	0.148 (p=0.142)	0.118 (p=0.241)	-0.066 (p=0.517)	0.041 (p=0.686)
NT-proBNP (IU/L)	0.386 (p<0.001)	0.099 (p=0.329)	0.148 (p=0.142)	(p<0.001)	0.606 (p<0.001)	-0.315 (p=0.001)	-0.142 (p=0.158)
ANP (IU/L)	0.268 (p=0.007)	0.074 (p=0.464)	0.118 (p=0.241)	0.606 (p<0.001)	(p<0.001)	-0.211 (p=0.035)	-0.175 (p=0.082)
Fetuin A (IU/L)	-0.066 (p=0.517)	0.043 (p=0.672)	-0.066 (p=0.517)	-0.315 (p=0.001)	-0.211 (p=0.035)	(p<0.001)	0.144 (p=0.153)
Total cholesterol (mg/dL)	-0.029 (p=0.775)	0.128 (p=0.203)	0.041 (p=0.686)	-0.142 (p=0.158)	-0.175 (p=0.082)	0.144 (p=0.153)	(p<0.001)

1.7.8 rezolutie 1h post coro

Figure 1: Distribution of the biomarkers (log scale) by … (— median, ◆ mean).

Table 12: Distribution of the biomarkers by ….

Variable	Details	<1/2	≥1/2	Total	Statistics
outcome		46 (46.0%)	54 (54.0%)	100
Troponine (ng/mL)	M (min:max)	0.27 (0.01:8.48)	0.26 (0.01:9.71)	0.26 (0.01:9.71)	MW: p=0.426
	μ ±SD	1.01 ±1.87	0.788 ±1.5	0.892 ±1.68
NT-proBNP (IU/L)	M (min:max)	600 (30:6000)	540 (35:6000)	575 (30:6000)	MW: p=0.382
	μ ±SD	1301.96 ±1537.5	992.69 ±1174.7	1134.95 ±1355.4
Fetuin A (IU/L)	M (min:max)	117.5 (20:280)	195 (50:900)	155 (20:900)	MW: p=0.002
	μ ±SD	141.63 ±63.8	239.17 ±179.1	194.30 ±146.3
μ ±SD = Mean (standard deviation); M (min:max) = Median (min:max); MW = Mann-Whitney Test;

1.7.8.1 ROC

Figure 2: Area under ROC for Fetuin A (IU/L), by … . Maximal accuracy was found at the cutoff of 175 IU/L (67.0%, black line), with Se 73.9%, blue line) and Sp (61.1%, red line). Dashed lines show NPV (blue, 73.3%) and PPV (red, 61.8%). Final AUC was 68% (95% CI: 58%-79%).

Table 13: Performance of Fetuin A (IU/L) as a diagnostic tool for …. All values were tested as cutoffs, resulting in a maximal accuracy at 175 IU/L.

Cutoff	Acc	Se	Sp	PPV	NPV
20	55.0%	2.2%	100.0%	100.0%	54.5%
45	56.0%	4.3%	100.0%	100.0%	55.1%
50	55.0%	4.3%	98.1%	66.7%	54.6%
65	53.0%	4.3%	94.4%	40.0%	53.7%
70	52.0%	4.3%	92.6%	33.3%	53.2%
75	54.0%	8.7%	92.6%	50.0%	54.3%
80	55.0%	10.9%	92.6%	55.6%	54.9%
90	57.0%	17.4%	90.7%	61.5%	56.3%
95	58.0%	30.4%	81.5%	58.3%	57.9%
100	59.0%	37.0%	77.8%	58.6%	59.2%
105	60.0%	41.3%	75.9%	59.4%	60.3%
110	62.0%	45.7%	75.9%	61.8%	62.1%
115	64.0%	50.0%	75.9%	63.9%	64.1%
120	64.0%	52.2%	74.1%	63.2%	64.5%
125	63.0%	52.2%	72.2%	61.5%	63.9%
130	64.0%	54.3%	72.2%	62.5%	65.0%
140	65.0%	58.7%	70.4%	62.8%	66.7%
145	64.0%	60.9%	66.7%	60.9%	66.7%
150	65.0%	63.0%	66.7%	61.7%	67.9%
155	65.0%	67.4%	63.0%	60.8%	69.4%
160	65.0%	69.6%	61.1%	60.4%	70.2%
170	66.0%	71.7%	61.1%	61.1%	71.7%
175	67.0%	73.9%	61.1%	61.8%	73.3%
180	64.0%	73.9%	55.6%	58.6%	71.4%
185	64.0%	76.1%	53.7%	58.3%	72.5%
190	64.0%	78.3%	51.9%	58.1%	73.7%
195	62.0%	78.3%	48.1%	56.2%	72.2%
200	62.0%	80.4%	46.3%	56.1%	73.5%
205	63.0%	84.8%	44.4%	56.5%	77.4%
215	63.0%	87.0%	42.6%	56.3%	79.3%
235	62.0%	87.0%	40.7%	55.6%	78.6%
240	59.0%	87.0%	35.2%	53.3%	76.0%
245	60.0%	89.1%	35.2%	53.9%	79.2%
250	58.0%	89.1%	31.5%	52.6%	77.3%
255	57.0%	89.1%	29.6%	51.9%	76.2%
260	56.0%	93.5%	24.1%	51.2%	81.2%
265	57.0%	95.7%	24.1%	51.8%	86.7%
270	56.0%	97.8%	20.4%	51.1%	91.7%
280	56.0%	100.0%	18.5%	51.1%	100.0%
310	55.0%	100.0%	16.7%	50.5%	100.0%
390	54.0%	100.0%	14.8%	50.0%	100.0%
395	53.0%	100.0%	13.0%	49.5%	100.0%
410	52.0%	100.0%	11.1%	48.9%	100.0%
510	50.0%	100.0%	7.4%	47.9%	100.0%
530	49.0%	100.0%	5.6%	47.4%	100.0%
560	48.0%	100.0%	3.7%	46.9%	100.0%
900	46.0%	100.0%	0.0%	46.0%

NT-proBNP was not a good predictor for …, with an AUC 55% (95% CI: 44%-67%).

Figure 3: Area under ROC for NT-proBNP (IU/L), by … . Maximal accuracy was found at the cutoff of 3000 IU/L (59.0%, black line), with Se (15.2%, blue line) and Sp (96.3%, red line). Dashed lines show NPV (blue, 57.1%) and PPV (red, 77.8%). Final AUC was 55% (95% CI: 44%-67%).

Table 14: Performance of NT-proBNP (IU/L) as a diagnostic tool for …. All values were tested as cutoffs, resulting in a maximal accuracy at 3000 IU/L.

Cutoff	Acc	Se	Sp	PPV	NPV
30	45.0%	97.8%	0.0%	45.5%	0.0%
35	46.0%	97.8%	1.9%	45.9%	50.0%
40	45.0%	95.7%	1.9%	45.4%	33.3%
45	46.0%	95.7%	3.7%	45.8%	50.0%
55	47.0%	95.7%	5.6%	46.3%	60.0%
60	46.0%	93.5%	5.6%	45.7%	50.0%
80	47.0%	91.3%	9.3%	46.2%	55.6%
85	48.0%	91.3%	11.1%	46.7%	60.0%
90	50.0%	91.3%	14.8%	47.7%	66.7%
110	48.0%	87.0%	14.8%	46.5%	57.1%
120	49.0%	84.8%	18.5%	47.0%	58.8%
130	51.0%	84.8%	22.2%	48.1%	63.2%
140	50.0%	82.6%	22.2%	47.5%	60.0%
150	50.0%	80.4%	24.1%	47.4%	59.1%
160	51.0%	80.4%	25.9%	48.1%	60.9%
170	50.0%	78.3%	25.9%	47.4%	58.3%
180	50.0%	76.1%	27.8%	47.3%	57.7%
200	52.0%	76.1%	31.5%	48.6%	60.7%
260	51.0%	73.9%	31.5%	47.9%	58.6%
280	49.0%	69.6%	31.5%	46.4%	54.8%
300	50.0%	69.6%	33.3%	47.1%	56.2%
310	49.0%	65.2%	35.2%	46.2%	54.3%
330	51.0%	65.2%	38.9%	47.6%	56.8%
340	50.0%	63.0%	38.9%	46.8%	55.3%
380	49.0%	60.9%	38.9%	45.9%	53.8%
420	50.0%	60.9%	40.7%	46.7%	55.0%
440	49.0%	58.7%	40.7%	45.8%	53.7%
450	50.0%	58.7%	42.6%	46.6%	54.8%
480	51.0%	58.7%	44.4%	47.4%	55.8%
500	52.0%	58.7%	46.3%	48.2%	56.8%
530	54.0%	58.7%	50.0%	50.0%	58.7%
550	54.0%	56.5%	51.9%	50.0%	58.3%
560	55.0%	56.5%	53.7%	51.0%	59.2%
570	56.0%	56.5%	55.6%	52.0%	60.0%
580	55.0%	54.3%	55.6%	51.0%	58.8%
600	53.0%	47.8%	57.4%	48.9%	56.4%
620	54.0%	47.8%	59.3%	50.0%	57.1%
630	55.0%	47.8%	61.1%	51.2%	57.9%
700	56.0%	47.8%	63.0%	52.4%	58.6%
715	57.0%	47.8%	64.8%	53.7%	59.3%
800	57.0%	45.7%	66.7%	53.8%	59.0%
820	58.0%	45.7%	68.5%	55.3%	59.7%
830	57.0%	43.5%	68.5%	54.1%	58.7%
840	56.0%	41.3%	68.5%	52.8%	57.8%
900	57.0%	41.3%	70.4%	54.3%	58.5%
910	56.0%	39.1%	70.4%	52.9%	57.6%
980	55.0%	37.0%	70.4%	51.5%	56.7%
1 060	54.0%	34.8%	70.4%	50.0%	55.9%
1 200	55.0%	34.8%	72.2%	51.6%	56.5%
1 220	54.0%	32.6%	72.2%	50.0%	55.7%
1 350	53.0%	30.4%	72.2%	48.3%	54.9%
1 400	53.0%	28.3%	74.1%	48.1%	54.8%
1 410	52.0%	26.1%	74.1%	46.2%	54.1%
1 600	53.0%	26.1%	75.9%	48.0%	54.7%
1 750	52.0%	23.9%	75.9%	45.8%	53.9%
1 800	53.0%	23.9%	77.8%	47.8%	54.5%
2 000	54.0%	23.9%	79.6%	50.0%	55.1%
2 060	55.0%	23.9%	81.5%	52.4%	55.7%
2 100	54.0%	21.7%	81.5%	50.0%	55.0%
2 200	57.0%	21.7%	87.0%	58.8%	56.6%
2 300	57.0%	19.6%	88.9%	60.0%	56.5%
2 700	58.0%	19.6%	90.7%	64.3%	57.0%
2 800	57.0%	15.2%	92.6%	63.6%	56.2%
2 950	58.0%	15.2%	94.4%	70.0%	56.7%
3 000	59.0%	15.2%	96.3%	77.8%	57.1%
3 100	58.0%	13.0%	96.3%	75.0%	56.5%
3 200	57.0%	10.9%	96.3%	71.4%	55.9%
3 600	58.0%	10.9%	98.1%	83.3%	56.4%
4 010	57.0%	8.7%	98.1%	80.0%	55.8%
4 060	56.0%	6.5%	98.1%	75.0%	55.2%
5 050	55.0%	4.3%	98.1%	66.7%	54.6%
5 200	54.0%	2.2%	98.1%	50.0%	54.1%
6 000	54.0%	0.0%	100.0%		54.0%

Figure 4: Area under ROC for Troponine (ng/mL), by … . Final AUC was 55% (95% CI: 43%-66%).

Table 15: Performance of Troponine (ng/mL) as a diagnostic tool for …. All values were tested as cutoffs, resulting in a maximal accuracy slightly above 50% for all values.

Cutoff	Acc	Se	Sp	PPV	NPV
0.008	47.0%	100.0%	1.9%	46.5%	100.0%
0.009	46.0%	97.8%	1.9%	45.9%	50.0%
0.012	48.0%	97.8%	5.6%	46.9%	75.0%
0.013	49.0%	97.8%	7.4%	47.4%	80.0%
0.014	50.0%	97.8%	9.3%	47.9%	83.3%
0.018	51.0%	97.8%	11.1%	48.4%	85.7%
0.020	52.0%	95.7%	14.8%	48.9%	80.0%
0.040	50.0%	91.3%	14.8%	47.7%	66.7%
0.042	51.0%	91.3%	16.7%	48.3%	69.2%
0.043	52.0%	91.3%	18.5%	48.8%	71.4%
0.048	51.0%	89.1%	18.5%	48.2%	66.7%
0.050	50.0%	87.0%	18.5%	47.6%	62.5%
0.056	51.0%	87.0%	20.4%	48.2%	64.7%
0.060	52.0%	87.0%	22.2%	48.8%	66.7%
0.065	53.0%	87.0%	24.1%	49.4%	68.4%
0.067	52.0%	84.8%	24.1%	48.8%	65.0%
0.074	51.0%	82.6%	24.1%	48.1%	61.9%
0.077	52.0%	82.6%	25.9%	48.7%	63.6%
0.091	53.0%	82.6%	27.8%	49.4%	65.2%
0.092	54.0%	82.6%	29.6%	50.0%	66.7%
0.102	55.0%	82.6%	31.5%	50.7%	68.0%
0.105	54.0%	80.4%	31.5%	50.0%	65.4%
0.107	53.0%	78.3%	31.5%	49.3%	63.0%
0.111	52.0%	76.1%	31.5%	48.6%	60.7%
0.114	53.0%	76.1%	33.3%	49.3%	62.1%
0.121	54.0%	76.1%	35.2%	50.0%	63.3%
0.128	54.0%	73.9%	37.0%	50.0%	62.5%
0.130	53.0%	71.7%	37.0%	49.3%	60.6%
0.148	52.0%	69.6%	37.0%	48.5%	58.8%
0.155	51.0%	67.4%	37.0%	47.7%	57.1%
0.162	52.0%	67.4%	38.9%	48.4%	58.3%
0.168	53.0%	67.4%	40.7%	49.2%	59.5%
0.170	54.0%	67.4%	42.6%	50.0%	60.5%
0.171	53.0%	65.2%	42.6%	49.2%	59.0%
0.182	52.0%	63.0%	42.6%	48.3%	57.5%
0.190	52.0%	60.9%	44.4%	48.3%	57.1%
0.195	51.0%	58.7%	44.4%	47.4%	55.8%
0.200	50.0%	56.5%	44.4%	46.4%	54.5%
0.203	52.0%	56.5%	48.1%	48.1%	56.5%
0.209	51.0%	54.3%	48.1%	47.2%	55.3%
0.219	50.0%	52.2%	48.1%	46.2%	54.2%
0.233	51.0%	52.2%	50.0%	47.1%	55.1%
0.235	50.0%	50.0%	50.0%	46.0%	54.0%
0.283	51.0%	50.0%	51.9%	46.9%	54.9%
0.297	50.0%	47.8%	51.9%	45.8%	53.8%
0.300	49.0%	45.7%	51.9%	44.7%	52.8%
0.314	50.0%	45.7%	53.7%	45.7%	53.7%
0.315	49.0%	43.5%	53.7%	44.4%	52.7%
0.320	50.0%	43.5%	55.6%	45.5%	53.6%
0.378	51.0%	43.5%	57.4%	46.5%	54.4%
0.382	52.0%	43.5%	59.3%	47.6%	55.2%
0.400	53.0%	43.5%	61.1%	48.8%	55.9%
0.414	52.0%	41.3%	61.1%	47.5%	55.0%
0.440	53.0%	41.3%	63.0%	48.7%	55.7%
0.460	55.0%	41.3%	66.7%	51.4%	57.1%
0.470	54.0%	39.1%	66.7%	50.0%	56.2%
0.515	53.0%	37.0%	66.7%	48.6%	55.4%
0.526	54.0%	37.0%	68.5%	50.0%	56.1%
0.560	53.0%	34.8%	68.5%	48.5%	55.2%
0.590	54.0%	34.8%	70.4%	50.0%	55.9%
0.612	55.0%	34.8%	72.2%	51.6%	56.5%
0.641	54.0%	32.6%	72.2%	50.0%	55.7%
0.660	55.0%	32.6%	74.1%	51.7%	56.3%
0.685	54.0%	30.4%	74.1%	50.0%	55.6%
0.780	53.0%	28.3%	74.1%	48.1%	54.8%
0.830	52.0%	26.1%	74.1%	46.2%	54.1%
0.900	53.0%	26.1%	75.9%	48.0%	54.7%
1.020	52.0%	23.9%	75.9%	45.8%	53.9%
1.100	51.0%	21.7%	75.9%	43.5%	53.2%
1.120	52.0%	21.7%	77.8%	45.5%	53.8%
1.220	53.0%	21.7%	79.6%	47.6%	54.4%
1.230	54.0%	21.7%	81.5%	50.0%	55.0%
1.360	55.0%	21.7%	83.3%	52.6%	55.6%
1.400	54.0%	19.6%	83.3%	50.0%	54.9%
1.560	53.0%	17.4%	83.3%	47.1%	54.2%
1.570	52.0%	15.2%	83.3%	43.8%	53.6%
1.640	52.0%	13.0%	85.2%	42.9%	53.5%
1.950	53.0%	13.0%	87.0%	46.2%	54.0%
1.960	54.0%	13.0%	88.9%	50.0%	54.5%
1.980	56.0%	13.0%	92.6%	60.0%	55.6%
2.070	55.0%	10.9%	92.6%	55.6%	54.9%
2.080	56.0%	10.9%	94.4%	62.5%	55.4%
2.130	55.0%	8.7%	94.4%	57.1%	54.8%
2.930	56.0%	8.7%	96.3%	66.7%	55.3%
3.030	55.0%	6.5%	96.3%	60.0%	54.7%
4.240	56.0%	6.5%	98.1%	75.0%	55.2%
6.400	55.0%	4.3%	98.1%	66.7%	54.6%
7.600	54.0%	2.2%	98.1%	50.0%	54.1%
8.480	53.0%	0.0%	98.1%	0.0%	53.5%
9.710	54.0%	0.0%	100.0%		54.0%

Adjusted for all biomarkers, only fetuin A was significantly correlated to the increase in odds of … <1/2. Every doubling of fetuin values ‘increases’ the odds … <1/2 (compared to ≥1/2) by 0.39 (equivalent to a decrease by a factor of 2.55).

Table 16: Multivariate logistic regression for the adjusted odds ratio of … <1/2, predicted by biomarkers (log2 transformed).

Predictor	Adj-OR (95% CI)	p value
model 0
(Intercept)	1 532.002 (8.43, 619 626.74)	p=0.010
Troponine (ng/mL)	1.094 (0.90, 1.34)	p=0.378
NT-proBNP (IU/L)	0.947 (0.73, 1.22)	p=0.676
Fetuin A (IU/L)	0.392 (0.21, 0.68)	p=0.002

Figure 5: Multivariate logistic regression for the adjusted odds ratio of … <1/2, predicted by biomarkers (log2 transformed). P-value code ** means p<0.01.

2 References

1. R Core Team (2019). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.