Compare expression patterns by diabetes group (contrasts are notDiabetic v diabetesSulfonyureas, and notDiabetic v diabetesMetformin
| DICER1 | IGF1 | let.7c.5p | miR.125b.5p | mir.130a.3p | mir.20a.5p | miR.34a.5p | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| diabGrpdiabetesSulfonyureas | 0.316 | 12.300 | * | 1.321 | 0.252 | 1.064 | ** | -4.651 | 0.091 | |||||
| diabGrpdiabetesMetformin | 0.572 | * | 4.519 | 8.883 | 0.018 | 0.515 | -8.446 | 0.393 |
Add demographic covariates to the comparisons.
We don't have sufficient degrees of freedom to examine all-way interactions so these analyses are restricted to just main effects of diabetes groups and demographics.
| DICER1 | IGF1 | let.7c.5p | miR.125b.5p | mir.130a.3p | mir.20a.5p | miR.34a.5p | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| diabGrpdiabetesSulfonyureas | 0.398 | 11.776 | * | 1.343 | 0.362 | 1.060 | ** | -5.667 | 0.067 | |||||
| diabGrpdiabetesMetformin | 0.587 | * | 5.149 | 8.872 | -0.037 | 0.517 | -7.938 | 0.405 | ||||||
| Age0medAbove | 0.212 | 3.440 | -15.888 | -0.416 | -0.664 | -3.874 | -0.044 | |||||||
| SexMen | -0.420 | -9.738 | -3.576 | -0.358 | -0.092 | 9.936 | -0.207 | |||||||
| RaceAfrAm | 0.195 | 5.050 | 7.115 | 0.948 | 1.046 | 12.899 | 0.636 | |||||||
| PovStatBelow | -0.445 | 7.699 | -0.221 | -1.100 | 0.038 | 10.157 | 0.240 |
Although none of the demographic main effects were significant, it appears as though median age has an effect on let.7c.5p but only when race is also in the model. At best, this is suggestive and probably not worth mentioning without some replication.
| DICER1 | IGF1 | let.7c.5p | miR.125b.5p | mir.130a.3p | mir.20a.5p | miR.34a.5p | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| diabGrpdiabetesSulfonyureas | 0.319 | 12.235 | * | 1.321 | 0.252 | 1.064 | ** | -4.651 | 0.091 | |||||
| diabGrpdiabetesMetformin | 0.575 | * | 4.454 | 8.883 | 0.018 | 0.515 | -8.446 | 0.393 | ||||||
| Age0medAbove | 0.144 | 3.705 | -16.012 | * | -0.572 | -0.661 | -2.257 | -0.018 | ||||||
| RaceAfrAm | 0.024 | 3.501 | 5.992 | 0.692 | 1.023 | 17.292 | 0.605 |