Image depicting the 4 possible c-Fos/c-Jun dimers. From: VÁMOSI, G., BAUDENDISTEL, N., VON DER LIETH, C., SZALÓKI, N., MOCSÁR, G., MÜLLER, G., BRÁZDA, P., WALDECK, W., DAMJANOVICH, S., LANGOWSKI, J. & TÓTH, K.Conformation of the c-Fos/c-Jun Complex In Vivo: A Combined FRET, FCCS, and MD-Modeling Study., 2008.Biophysical Journal. Available from:https://doi.org/10.1529/biophysj.107.120766.

Image depicting the 4 possible c-Fos/c-Jun dimers. From: VÁMOSI, G., BAUDENDISTEL, N., VON DER LIETH, C., SZALÓKI, N., MOCSÁR, G., MÜLLER, G., BRÁZDA, P., WALDECK, W., DAMJANOVICH, S., LANGOWSKI, J. & TÓTH, K.Conformation of the c-Fos/c-Jun Complex In Vivo: A Combined FRET, FCCS, and MD-Modeling Study., 2008.Biophysical Journal. Available from:https://doi.org/10.1529/biophysj.107.120766.

c-Fos belongs to the Fos family and are used in conjunction with c-Jun to create activating protein 1, which is a transcription factor that is vital in gene expression (Mahner et al., 2008). c-Fos is known to play a role in several cellular activities, including cell growth, differentiation and signalling pathways (Mahner et al., 2008). In relation to tumour growth, it is known to have an inhibitory response on tumour suppressor genes and therefore plays a role in tumorigenesis in cancers such as ovarian cancer (Mahner et al., 2008).

References: MAHNER, S., BAASCH, C., SCHWARZ, J., HEIN, S., WÖLBER, L., JÄNICKE, F. & MILDE-LANGOSCH, K., 2008. C-Fos expression is a molecular predictor of progression and survival in epithelial ovarian carcinoma. British Journal of Cancer. 99(8), pp.1269-1275. Available from: 10.1038/sj.bjc.6604650.