Elk-1

Image from: Besnard, A., Galan-Rodriguez, B., Vanhoutte, P. and Caboche, J. (2011). Elk-1 a Transcription Factor with Multiple Facets in the Brain. Frontiers in Neuroscience, [online] 5. Available at: https://www.frontiersin.org/articles/10.3389/fnins.2011.00035/full [Accessed 8 Mar. 2020].

Elk-1 is a transcription factor that, using the serum response element, controls the expression of the immediate early gene (Besnard et al., 2011). C-Jun N terminal kinase and mitogen-activated protein kinases cause unique residues to be phosphorylated (Besnard et al., 2011). Serum response element dependent transcription is activated by the phosphorylation event caused by Elk-1 (Besnard et al., 2011). When Elk-1 is in its inactive form its resides in the cytoplasm and has an important function in neuronal activity (Besnard et al., 2011). The image below shows the domains and modifications (post-translational) of Elk-1.

References: BESNARD, A., GALAN-RODRIGUEZ, B., VANHOUTTE, P. & CABOCHE, J., 2011. Elk-1 a Transcription Factor with Multiple Facets in the Brain. Frontiers in Neuroscience. 5, pp.35. Available from: 10.3389/fnins.2011.00035.