Image from: LI, J. X., YU, F. & ZHANG, P., 2020. Crystal structure of plant Phospholipase D alpha comlex with phosphatidic acid. Israel: Weizmann Institute of Science.

Image from: LI, J. X., YU, F. & ZHANG, P., 2020. Crystal structure of plant Phospholipase D alpha comlex with phosphatidic acid. Israel: Weizmann Institute of Science.

Phospholipase D promotes the formation of phosphatidic acid by hydrolysing the phosphodiester bond in glycerophospholipids (McDermott, Wakelam and Morris, 2004). There are two isoforms of phospholipase D, that are controlled by protein kinases and GTP binding proteins (McDermott, Wakelam and Morris, 2004). In humans phospholipase D is also regulated by phosphatidylinositol 4,5-bisphophate (McDermott, Wakelam and Morris, 2004). This is also true in yeast cells (McDermott, Wakelam and Morris, 2004).

References: MCDERMOTT, M., WAKELAM, M.J. & MORRIS, A.J., 2004. Phospholipase D. Biochemistry and Cell Biology., pp.225-253. Available from:https://www.ncbi.nlm.nih.gov/pubmed/15052340.