Image from: Huerta-Reyes, M., Maya-Núñez, G., Pérez-Solis, M., López-Muñoz, E., Guillén, N., Olivo-Marin, J. and Aguilar-Rojas, A. (2019). Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs. Frontiers in Oncology, [online] 9. Available at: https://www.frontiersin.org/articles/10.3389/fonc.2019.00943/full [Accessed 8 Mar. 2020].

Image from: Huerta-Reyes, M., Maya-Núñez, G., Pérez-Solis, M., López-Muñoz, E., Guillén, N., Olivo-Marin, J. and Aguilar-Rojas, A. (2019). Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs. Frontiers in Oncology, [online] 9. Available at: https://www.frontiersin.org/articles/10.3389/fonc.2019.00943/full [Accessed 8 Mar. 2020].

These receptors do not have a C-terminal tail which makes them completely distinctive in G protein coupled receptors as this tail is often the cause of de-sensitisation (Shacham et al., 2005).

References: SHACHAM, S., CHEIFETZ, M.N., FRIDKIN, M., PAWSON, A.J., MILLAR, R.P. & NAOR, Z., 2005. Identification of Ser153in ICL2 of the Gonadotropin-releasing Hormone (GnRH) Receptor as a Phosphorylation-independent Site for Inhibition of GqCoupling. Journal of Biological Chemistry. 280(32), pp.28981-28988. Available from: 10.1074/jbc.M500312200.